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Articles de revues sur le sujet « Immunodeficiency states »

Auteur : Grafiati

Publié le 7 juin 2025

Mis à jour le 2 août 2025

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1

Rescigno, Ronald, and Marc Dinowitz. "Ophthalmic manifestations of immunodeficiency states." Clinical Reviews in Allergy & Immunology 20, no. 2 (2001): 163–81. http://dx.doi.org/10.1007/s12016-001-0001-7.

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Rescigno, Ronald, and Marc Dinowitz. "Ophthalmic Manifestations of Immunodeficiency States." Clinical Reviews in Allergy & Immunology 20, no. 2 (2001): 162–82. http://dx.doi.org/10.1385/criai:20:2:162.

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Aliskandieva, Zuleykha A., Alaudin M. Aliskandiev, Rakhmat M. Idrisova, Magomed I. Izrailov, and Kistaman М. Amirova. "Primary immunodeficiency in the 9-year child." Russian Pediatric Journal 26, no. 6 (2023): 455–58. http://dx.doi.org/10.46563/1560-9561-2023-26-6-455-458.

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Primary immunodeficiency conditions are a heterogeneous group of disorders caused by defects in various parts of the immune system, manifested in the form of recurrent infectious and autoimmune diseases of varying severity. The authors describe own clinical observation to determine the principles of diagnosis and treatment of primary immunodeficiency in children in modern conditions. The average age of diagnosis of an immunodeficiency condition has been established to be best over 30 days, but often this time increases to several years. The data of the enrolment of primary immunodeficiency sta

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4

LAYON, JOSEPH, MICHAEL WARZYNSKI, and AHAMED IDRIS. "Acquired immunodeficiency syndrome in the United States." Critical Care Medicine 14, no. 9 (1986): 819–27. http://dx.doi.org/10.1097/00003246-198609000-00014.

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Busch, K. A. "Psychotic states in human immunodeficiency virus illness." Current Opinion in Psychiatry 2, no. 1 (1989): 3–6. http://dx.doi.org/10.1097/00001504-198902000-00002.

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6

Gazzard, B., and C. Blanshard. "Diarrhoea in aids and other immunodeficiency states." Baillière's Clinical Gastroenterology 7, no. 2 (1993): 387–419. http://dx.doi.org/10.1016/0950-3528(93)90047-v.

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Demicheva, Ekaterina, Fernando Jonathan Polanco Espino, Pavel Vedeneev, et al. "Comparative Study of Lipid Profile for Mice Treated with Cyclophosphamide by HPLC-HRMS and Bioinformatics." Metabolites 15, no. 1 (2025): 60. https://doi.org/10.3390/metabo15010060.

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Purpose: Immunodeficiency conditions, which are characterized by reduced immune activity that promotes the development of chronic diseases, are needed for efficient monitoring. A promising area of monitoring and early diagnosis of immunodeficiency diseases is the determination of metabolic biomarkers in the blood. Methods: In this work, we identified a set of lipid biomarkers of immunodeficiency states by performing high-performance liquid chromatography–high-resolution mass spectrometry (HPLC-HRMS) analysis of blood plasma samples from mice and processing them with bioinformatics approaches.

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Jones, Jessica, Aiman Faruqi, James Sullivan, Cassandra Calabrese, and Leonard Calabrese. "COVID-19 Outcomes in Patients Undergoing B Cell Depletion Therapy and Those with Humoral Immunodeficiency States: A Scoping Review." Pathogens and Immunity 6, no. 1 (2021): 76–103. http://dx.doi.org/10.20411/pai.v6i1.435.

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Background: The role of humoral immunity has been well established in reducing infection risk and facilitating viral clearance in patients with COVID-19. However, the relationship between specific antibody responses and severity of COVID-19 is less well understood. Methods: To address this question and identify gaps in knowledge, we utilized the methodology of a scoping review to interrogate risk of infection and clinical outcomes of COVID-19 in patients with iatrogenic and inborn humoral immunodeficiency states based on existing literature. Results: Among patients with iatrogenic B-cell deple

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Labisi, Titilola O., Anthony T. Podany, Nada A. Fadul, Jason D. Coleman, and Keyonna M. King. "Factors associated with viral suppression among cisgender women living with human immunodeficiency virus in the United States: An integrative review." Women's Health 18 (January 2022): 174550572210922. http://dx.doi.org/10.1177/17455057221092267.

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Introduction: Women account for 23% of new human immunodeficiency virus diagnoses in the United States, yet remain understudied. Adherence to antiretroviral therapy and consequent viral suppression are keys to preventing human immunodeficiency virus transmission, reducing risk of drug resistance, and improving health outcomes. Objectives: This review identified and synthesized peer-reviewed studies in the United States describing factors associated with viral suppression among cisgender women living with human immunodeficiency virus. Methods: We searched five databases: Cumulative Index to Nur

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Kuzmenko, N. B., T. V. Varlamova, A. A. Mukhina, et al. "EXPERIENCE OF PRENATAL DIAGNOSIS OF PRIMARY IMMUNODEFICIENCY STATES." Pediatria. Journal named after G.N. Speransky 98, no. 3 (2019): 44–48. http://dx.doi.org/10.24110/0031-403x-2019-98-3-44-48.

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Yartsev, M. N., and M. V. Plachtienko. "Recurrent upper respiratory tract infections and immune defi-ciency in children." Russian Journal of Allergy 7, no. 5 (2009): 58–66. http://dx.doi.org/10.36691/rja905.

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The lecture is devoted to results of clinical and immunological investigation of 614 children with 20 forms of primary immunodeficiency states and more than 8000 children with «frequent infections». The observations were performed in children unit of the Institute of Immunology in the years 1981-2010. The main features of primary immunodeficiency and secondary immunodeficiency and the term «immunocompromised child» are analyzed in details.

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12

CALDWELL, M. BLAKE, PATRICIA L. FLEMING, and MARGARET J. OXTOBY. "Estimated Number of AIDS Orphans in the United States." Pediatrics 90, no. 3 (1992): 482. http://dx.doi.org/10.1542/peds.90.3.482.

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To the Editor.— The human immunodeficiency virus (HIV) epidemic in child-bearing women impacts our society in a number of ways. One of these is the legacy of uninfected children left without their mothers when these women succumb to acquired immunodeficiency syndrome (AIDS). We have calculated a crude estimate of the current and future number of these AIDS orphans. As of December 31, 1991, 21 225 women (≥13 years of age) with AIDS were reported to the Centers for Disease Control from the United States, Puerto Rico, and the Trusts and Territories; 17 910 (84%) were of reproductive age (15 to 44

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13

Lytvynenko, M. V., and V. V. Gargin. "Morphometric peculiarities of the cervix uteri in immunodeficiency states." Reports of Morphology 26, no. 3 (2020): 58–63. http://dx.doi.org/10.31393/morphology-journal-2020-26(3)-08.

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Enhancing each other’s effects – HIV infection and the changes caused by alcohol abuse, trigger a chain of pathological reactions that sometimes lead to reversible and often irreversible pathological processes in the cervix uteri (CU). Local and general decrease in immunoresistance invariably leads to disturbance of physiological CU microbiome. Given all the above, the aim of our work was to identify pathological changes in CU that occur in HIV-infected women on the background of chronic alcoholism. Section material of 110 women of reproductive age from 20 to 40 years, which were divided into

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14

Marcy, Theodore W., and Herbert Y. Reynolds. "Pulmonary Consequences of Congenital and Acquired Primary Immunodeficiency States." Clinics in Chest Medicine 10, no. 4 (1989): 503–19. http://dx.doi.org/10.1016/s0272-5231(21)00653-5.

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15

Hariri, Susan, and Matthew T. McKenna. "Epidemiology of Human Immunodeficiency Virus in the United States." Clinical Microbiology Reviews 20, no. 3 (2007): 478–88. http://dx.doi.org/10.1128/cmr.00006-07.

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SUMMARY The human immunodeficiency virus (HIV) epidemic emerged in the early 1980s with HIV infection as a highly lethal disease among men who have sex with men and among frequent recipients of blood product transfusions. Advances in the treatment of HIV infection have resulted in a fundamental shift in its epidemiology, to a potentially chronic and manageable condition. However, challenges in the prevention of this infection remain. In particular, increasing evidence suggests that transmission of drug-resistant virus is becoming more common and that the epidemic is having a profound impact on

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16

Heneghan, Michael A., Fiona M. Stevens, Eilis M. Cryan, Ross H. Warner, and Ciaran F. McCarthy. "Celiac Sprue and Immunodeficiency States: A 25-Year Review." Journal of Clinical Gastroenterology 25, no. 2 (1997): 421–25. http://dx.doi.org/10.1097/00004836-199709000-00004.

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17

Toubi, Elias, and Amos Etzioni. "Intravenous Immunoglobulin in Immunodeficiency States: State of the Art." Clinical Reviews in Allergy & Immunology 29, no. 3 (2005): 167–72. http://dx.doi.org/10.1385/criai:29:3:167.

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18

Peterman, T. A. "Transfusion-associated acquired immunodeficiency syndrome in the United States." JAMA: The Journal of the American Medical Association 254, no. 20 (1985): 2913–17. http://dx.doi.org/10.1001/jama.254.20.2913.

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Peterman, Thomas A. "Transfusion-Associated Acquired Immunodeficiency Syndrome in the United States." JAMA: The Journal of the American Medical Association 254, no. 20 (1985): 2913. http://dx.doi.org/10.1001/jama.1985.03360200065028.

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20

Valencia Deray, Kristen G., Cassie Weyland, Diana Jeang, Gayatri Mirani, and Lindsay H. Cameron. "A 6-year-old child with a new diagnosis of perinatal human immunodeficiency virus infection." SAGE Open Medical Case Reports 10 (January 2022): 2050313X2211442. http://dx.doi.org/10.1177/2050313x221144208.

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Perinatal human immunodeficiency virus transmission, while rare in the United States, should be considered in children with a history of recurrent infections, chronic respiratory symptoms and developmental delay. A delayed diagnosis of human immunodeficiency virus in children can lead to significant morbidity and mortality. We present a 6-year-old male who presented for evaluation and management of antibiotic refractory chronic cough and purulent nasal secretions, with a history of recurrent bacterial pneumonias and sinus infections, disseminated varicella zoster, and global developmental dela

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Eddy Warman, Nur ‘Aini, and Nurul Yaqeen Mohd Esa. "A Rare and Challenging Case of Pulmonary Mycobacterium genavense in an Immunocompetent Adult." Journal of Clinical and Health Sciences 3, no. 1 (2018): 47. http://dx.doi.org/10.24191/jchs.v3i1.6158.

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Mycobacterium genavense, a non-tuberculous mycobacterium (NTM), usually affects patients severely immunodeficient from human immunodeficiency virus (HIV) infection or any other immunocompromised states. We reported a case in a 70-year-old female with well-controlled diabetes and history of proximal cystic bronchiectasis. She presented with 2 months history of cough, haemoptysis, and night sweats of which serial sputa were positive for acid-fast bacilli and the culture repeatedly grew M. genavense. Treatment with rifampicin, ofloxacin, and clarithromycin was complicated with drug-induced liver

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22

Pau, Alice K., Ian R. McNicholl, and Kenneth J. Pursell. "Active Immunization in HIV‐infected Patients." Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 16, no. 2 (1996): 163–70. http://dx.doi.org/10.1002/j.1875-9114.1996.tb02934.x.

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Patients infected with human immunodeficiency virus (HIV) are at risk for various viral and bacterial infections. Active immunization with currently available vaccines may reduce the risk of some vaccine‐preventable diseases in this population. Based on available data, most vaccines used in the United States are safe in HIV‐infected adults and children. Their clinical efficacy in these individuals is not well defined, although it appears that patients in the earlier stages of infection are more likely to mount a protective antibody response than those in the later stages. Current guidelines fo

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23

Roths, J. B., A. L. Smith, and C. L. Sidman. "Lethal exacerbation of Pneumocystis carinii pneumonia in severe combined immunodeficiency mice after infection by pneumonia virus of mice." Journal of Experimental Medicine 177, no. 4 (1993): 1193–98. http://dx.doi.org/10.1084/jem.177.4.1193.

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Mice homozygous for the mutant allele scid (severe combined immunodeficiency) have been described as excellent models for Pneumocystis carinii (Pc) pneumonia (PCP), a major health problem in patients with acquired immune deficiency syndrome (AIDS) and other immunodeficiency states. Other microorganisms have been shown to infect AIDS patients simultaneously with Pc, but whether one opportunist is able to directly influence the pathogenicity of another has not been determined previously. We have deliberately coinfected scid mice (with extent Pc infection) with a variety of primarily pneumotropic

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24

Krilov, Leonard R., Lorry G. Rubin, Michael Frogel, et al. "Disseminated Adenovirus Infection with Hepatic Necrosis in Patients with Human Immunodeficiency Virus Infection and Other Immunodeficiency States." Clinical Infectious Diseases 12, no. 2 (1990): 303–7. http://dx.doi.org/10.1093/clinids/12.2.303.

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Janssen, R. S., O. C. Nwanyanwu, R. M. Selik, and J. K. Stehr-Green. "Epidemiology of human immunodeficiency virus encephalopathy in the United States." Neurology 42, no. 8 (1992): 1472. http://dx.doi.org/10.1212/wnl.42.8.1472.

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Lapointe, Hope R., and P. Richard Harrigan. "Human Immunodeficiency Virus Phylogenetics in the United States—and Elsewhere." Journal of Infectious Diseases 222, no. 12 (2020): 1939–40. http://dx.doi.org/10.1093/infdis/jiaa108.

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LINDEGREN, MARY LOU, CELINE HANSON, KIM MILLER, ROBERT H. BYERS, and IDA ONORATO. "Epidemiology of human immunodeficiency virus infection in adolescents, United States." Pediatric Infectious Disease 13, no. 6 (1994): 525–35. http://dx.doi.org/10.1097/00006454-199406000-00012.

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O'Brien, Thomas R. "Human Immunodeficiency Virus Type 2 Infection in the United States." JAMA 267, no. 20 (1992): 2775. http://dx.doi.org/10.1001/jama.1992.03480200083029.

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Braun, M. M. "Acquired immunodeficiency syndrome and extrapulmonary tuberculosis in the United States." Archives of Internal Medicine 150, no. 9 (1990): 1913–16. http://dx.doi.org/10.1001/archinte.150.9.1913.

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Braun, M. Miles. "Acquired Immunodeficiency Syndrome and Extrapulmonary Tuberculosis in the United States." Archives of Internal Medicine 150, no. 9 (1990): 1913. http://dx.doi.org/10.1001/archinte.1990.00390200097018.

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Fernández Pérez, Evans R., Maya Hunter, and Rohit K. Katial. "United States trends in mortality rates for primary immunodeficiency diseases." Journal of Allergy and Clinical Immunology: In Practice 7, no. 3 (2019): 1045–48. http://dx.doi.org/10.1016/j.jaip.2018.09.030.

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Francis, Donald P. "The Prevention of Acquired Immunodeficiency Syndrome in the United States." JAMA 257, no. 10 (1987): 1357. http://dx.doi.org/10.1001/jama.1987.03390100095033.

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Dorsey, Morna J., and Jennifer M. Puck. "Newborn Screening for Severe Combined Immunodeficiency in the United States." Immunology and Allergy Clinics of North America 39, no. 1 (2019): 1–11. http://dx.doi.org/10.1016/j.iac.2018.08.002.

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Bosh, Karin A., John T. Brooks, and H. Irene Hall. "Human Immunodeficiency Virus Epidemic Control in the United States: An Assessment of Proposed UNAIDS Metrics, 2010–2015." Clinical Infectious Diseases 69, no. 8 (2019): 1431–33. http://dx.doi.org/10.1093/cid/ciz151.

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Abstract Epidemic control is necessary to eliminate human immunodeficiency virus infections. We assessed epidemic control in the United States by applying 4 proposed UNAIDS metrics to national surveillance data collected between 2010 and 2015. Although epidemic control in the United States is possible, progress by UNAIDS metrics has been mixed.

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PLOTKIN, STANLEY A. "Human Immunodeficiency Virus and Artificial Feeding." Pediatrics 83, no. 5 (1989): 804. http://dx.doi.org/10.1542/peds.83.5.804b.

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Dr Halsey has brought to my attention that a sentence in the human immunodeficiency virus (HIV) infection control statement (AAP News, September 1988) and perinatal statement (Pediatrics 1988;82:941-944) might be misinterpreted as advocating artificial feeding for HP/-infected infants in developing countries. It was our intention to advocate the use of artificial feeding by HIV-infected mothers only in the United States and other developed countries where safe water and hygienic practices are the norm. In other countries, the advantages of breast milk outweigh the possible risk of transmission

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Herman, Katherine E., and Katherine L. Tuttle. "Overview of secondary immunodeficiency." Allergy and Asthma Proceedings 45, no. 5 (2024): 347–54. http://dx.doi.org/10.2500/aap.2024.45.240063.

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In contrast to inborn errors of immunity (IEI), which are inherited disorders of the immune system that predispose to infections, malignancy, atopy, and immune dysregulation, secondary immunodeficiencies and immune dysregulation states (SID) are acquired impairments in immune cell function and/or regulation, and may be transient, reversible, or permanent. SIDs can derive from a variety of medical comorbidities, including protein-losing conditions, malnutrition, malignancy, certain genetic syndromes, prematurity, and chronic infections. Medications, including immunosuppressive and chemotherapeu

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Town, Katy, Yunfeng Tie, Sharoda Dasgupta, et al. "Sexually Transmitted Infection Testing Among Transgender Women Living with Human Immunodeficiency Virus in the United States: Medical Monitoring Project, 2015–2019." Clinical Infectious Diseases 73, no. 5 (2021): 899–902. http://dx.doi.org/10.1093/cid/ciab134.

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Abstract National guidelines recommend annual sexually transmitted infection testing for sexually active people living with human immunodeficiency virus, including transgender women. Using data from the US Medical Monitoring Project during 2015–2019, in the previous 12 months, 63.3% of sexually active transgender women who were human immunodeficiency virus positive were tested for syphilis, 56.6% for chlamydia, and 54.4% for gonorrhea.

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Conte, Antonio Hernandez, Michelle M. Kittleson, Deanna Dilibero, W. David Hardy, Jon A. Kobashigawa, and Fardad Esmailian. "Successful Orthotopic Heart Transplantation and Immunosuppressive Management in 2 Human Immunodeficiency Virus–Seropositive Patients." Texas Heart Institute Journal 43, no. 1 (2016): 69–74. http://dx.doi.org/10.14503/thij-14-4746.

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Few orthotopic heart transplantations have been performed in patients infected with the human immunodeficiency virus since the first such case was reported in 2001. Since that time, advances in highly active antiretroviral therapy have resulted in potent and durable suppression of the causative human immunodeficiency virus—accompanied by robust immune reconstitution, reversal of previous immunodeficiency, a marked decrease in opportunistic and other infections, and near-normal long-term survival. Although human immunodeficiency virus infection is not an absolute contraindication, few centers i

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Aoki, Yoshiyasu, and Giovanna Tosato. "HIV-1 Tat enhances Kaposi sarcoma–associated herpesvirus (KSHV) infectivity." Blood 104, no. 3 (2004): 810–14. http://dx.doi.org/10.1182/blood-2003-07-2533.

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Abstract The high frequency of Kaposi sarcoma (KS) in immunodeficiency states, particularly in patients with AIDS, has been attributed to increased replication of KS-associated herpesvirus (KSHV), a necessary cofactor for KS development. However, experimental KSHV infection of endothelial lineage cells that compose KS lesions has been difficult even in the absence of immune cells. Here we show that HIV-1 Tat protein can directly promote KSHV transmission. Full-length HIV-1 Tat and a 13–amino-acid peptide corresponding to the basic region of Tat specifically enhances the entry of KSHV into endo

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Skvortsov, Vsevolod. "HIV infection in nurse practice." Medsestra (Nurse), no. 11 (November 18, 2020): 18–24. http://dx.doi.org/10.33920/med-05-2011-02.

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This article focuses on the issues of classification, clinical manifestations, and approaches to the diagnosis of HIV infection and the possibility of using the domestic drug Licopid in the therapy of secondary immunodeficiency states.

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Olateju, Oluwatosin, Deb Dunn, Patricia McLaine, and Sharon Barrett. "Revision of Maryland Minor Consent Law on Human Immunodeficiency Virus Infection Prevention: An Outcome of Advocacy." HIV/AIDS Research and Treatment – Open Journal 7, no. 1 (2020): 10–17. http://dx.doi.org/10.17140/hartoj-7-134.

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Objectives To date, only few United States (US) states have explicit regulations that allow minors to independently give consent for human immunodeficiency virus infection (HIV) prevention treatments. This manuscript will reflect upon key advocacy efforts leading to the revision of the Maryland Minor Consent Law, evaluate current human immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/AIDS) prevention laws for minors in U.S. states, and highlight resources for health advocacy. Methods Between 2018-2019, public health professionals in Baltimore, Maryland reviewed the

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McVicker, Shireen, and M. Yousuf Karim. "IgE deficiency may indicate underlying hypogammaglobulinaemia?" Journal of Clinical Pathology 67, no. 9 (2014): 832–33. http://dx.doi.org/10.1136/jclinpath-2014-202461.

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Low serum immunoglobulin E (IgE) (<2 kU/L) found during allergy investigations may be a marker for other immunodeficiency states, in particular common variable immunodeficiency. The latter is characterised by recurrent infections, mainly respiratory, resulting in structural lung damage making early diagnosis important. We looked through 4013 samples retrospectively over a 12-month period to identify samples with IgE <2 kU/L. We identified 74/4013 (1.84%) with serum IgE levels <2 kU/L. Only 20 samples had serum immunoglobulin quantification and serum electrophoresis requested. Three of

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Agbo, Ejiofor Christopher, Uchejeso Mark Obeta, Akudo Ikpeazu, et al. "Socioeconomic and cultural factors driving Human Immunodeficiency Virus epidemic among female sex workers in Akwa-Ibom (South-south) and Benue (North-central) States of Nigeria." Journal of Public Health and Diseases 5, no. 4 (2020): 56–61. http://dx.doi.org/10.31248/jphd2022.118.

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This study was aimed at finding out the socioeconomic and cultural factors driving Human Immunodeficiency Virus infection (HIV) epidemics among Female Sex Workers (FSW) in South-south (Akwa-Ibom) and North-central (Benue) States where the infection prevalence is high in Nigeria. A standardized survey instrument was used in multistage cluster sampling approach in Benue and Akwa-Ibom States using sample size of 415 FSW. The study was done on the classified age brackets between 15 and 49 years with Akwa-Ibom having more participants at 20 to 24 years (32.8%) and Benue at 25 to 29 years (33%). Med

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Hovermale, Emily, Christopher Scalchunes, and Marcia Boyle. "Comparative effectiveness research in the United States and primary immunodeficiency diseases." Pharmaceuticals, Policy and Law 13, no. 3,4 (2011): 183–91. http://dx.doi.org/10.3233/ppl-2011-0323.

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Dailey, Andre F., Brooke E. Hoots, H. Irene Hall, et al. "Vital Signs: Human Immunodeficiency Virus Testing and Diagnosis Delays — United States." MMWR. Morbidity and Mortality Weekly Report 66, no. 47 (2017): 1300–1306. http://dx.doi.org/10.15585/mmwr.mm6647e1.

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46

Rogers, Martha F., M. Blake Caldwell, Marta L. Gwinn, and RJ Simonds. "Epidemiology of pediatric Human Immunodeficiency Virus infection in the United States." Acta Paediatrica 83, s400 (1994): 5–7. http://dx.doi.org/10.1111/j.1651-2227.1994.tb13324.x.

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GUTMAN, LAURA T., JOHN MOYE, BONNIE ZIMMER, and CHING TIAN. "Tuberculosis in human immunodeficiency virus-exposed or -infected United States children." Pediatric Infectious Disease Journal 13, no. 11 (1994): 963–68. http://dx.doi.org/10.1097/00006454-199411000-00006.

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48

McCormick, Marie C., Ezra C. Davidson, and Michael A. Stoto. "PREVENTING PERINATAL TRANSMISSION OF HUMAN IMMUNODEFICIENCY VIRUS IN THE UNITED STATES." Obstetrics & Gynecology 94, no. 5, Part 1 (1999): 795–98. http://dx.doi.org/10.1097/00006250-199911000-00030.

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49

Boyle, J. M., and R. H. Buckley. "Population Prevalence of Diagnosed Primary Immunodeficiency Diseases in the United States." Journal of Clinical Immunology 27, no. 5 (2007): 497–502. http://dx.doi.org/10.1007/s10875-007-9103-1.

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Kobrynski, Lisa, Rachel Waltenburg Powell, and Scott Bowen. "Prevalence and Morbidity of Primary Immunodeficiency Diseases, United States 2001–2007." Journal of Clinical Immunology 34, no. 8 (2014): 954–61. http://dx.doi.org/10.1007/s10875-014-0102-8.

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