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1

Siniawski, Henryk. Active Infective Aortic Valve Endocarditis with Infection Extension. Steinkopff, 2006. http://dx.doi.org/10.1007/3-7985-1629-4.

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Kocher, Ajar. Infective Endocarditis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199976805.003.0018.

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Infectious endocarditis (IE) is an infection of the heart’s innermost layer, the endothelium. Most cases require a predisposing injury to the endocardium to serve as a nidus for thrombus development, which in turn acts as nidus for bloodstream microorganisms. These intravascular microorganisms can result from dental and other invasive procedures, infected vascular catheters, and skin lesions. However, most episodes of IE result from transient bacteremia during menial tasks, such as chewing and brushing one’s teeth. Blood cultures and echocardiograms are critical for IE diagnosis. Transesophage
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3

Wilson, John W., and Lynn L. Estes. Infectious Syndromes in Adults. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190696924.003.0005.

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This section contains tables and text covering an exhaustive group of infectious syndromes including respiratory tract infections, infective endocarditis, intravascular catheter-related infections, central nervous system infections, urinary tract infections, soft-tissue infections, osteomyelitis, gastrointestinal infections, tick-borne infections, tuberculosis, sexually transmitted diseases, HIV, hepatitis, and fungal and zoonotic infections. Vaccination schedules, travel medicine, and bioterrorism are also reviewed.
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4

Orenstein, Robert. Clinical Syndromes in Infectious Diseases. Oxford University Press, 2012. http://dx.doi.org/10.1093/med/9780199755691.003.0411.

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This chapter approaches the field of infectious diseases from 3 perspectives. This second part covers clinical syndromes associated with various infections, such as infective endocarditis, meningitis, sexually transmitted infections, urinary tract infections, gastrointestinal infections, and soft-tissue infections. Symptoms, diagnosis, and treatment of these conditions are reviewed.
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5

Rodriguez-Iturbe, Bernardo, and Mark Haas. Post-infectious glomerulonephritis. Edited by Neil Turner. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0076.

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Post-infectious glomerulonephritis (GN) defines an inflammatory lesion involving exclusively or predominantly the glomeruli that is a consequence of an infectious disease. There are numerous bacterial, viral, and fungal infections associated with GN. This chapter acts as an overview of the following chapters that discuss only post-streptococcal GN, immunoglobulin A-dominant GN associated with staphylococcal infections, GN associated with bacterial endocarditis, with infected ventriculoatrial shunts (‘shunt nephritis’), and GN associated with deep-seated infections (osteomyelitis, visceral absc
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6

Rodriguez-Iturbe, Bernardo, and Mark Haas. Glomerulonephritis associated with endocarditis, deep-seated infections, and shunt nephritis. Edited by Neil Turner. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0079_update_001.

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Endocarditis is a cause of glomerulonephritis. Healthcare interventions (prosthetic valves, indwelling catheters, pacemaker wires) and intravenous drug abuse are presently the most common causes of endocarditis and Staphylococcus aureus is frequently the infecting bacteria. Shunt nephritis is a form of glomerulonephritis associated with infection of ventriculoatrial shunts implanted to relieve hydrocephalus and, typically, are caused by prolonged infections of low-pathogenicity microorganisms. This complication led to the replacement of the technique by ventriculoperitoneal shunts. Deep-seated
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7

Euster, Caren. Infection in the Intravenous Drug User. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199976805.003.0058.

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Injection drug abuse has spread worldwide and is increasing among young adults and adolescents. This chapter focuses on the management of acute infectious consequences of injection drug use (IDU), including skin and soft tissue infections, endocarditis, and systemic infections. The approach to infection is determined based upon etiology: local (injection site) infections, infections distant to the injection site, systemic infections, complications of primary infections, modifying factors, and infections associated with the patient with IDU’s lifestyle. Infections in patients with a history of
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8

Thuny, Franck, and Didier Raoult. Pathophysiology and causes of endocarditis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0160.

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Endocarditis is defined as an inflammation of the endocardial surface of the heart. This may include heart valves, mural endocardium or the endocardium that covers implanted material, such as prosthetic valves, pacemaker/defibrillator leads and catheters. Infective and non-infective-related causes must be distinguished. In most cases, the inflammation is related to a bacterial or fungal infection with oral streptococci, group D streptococci, staphylococci and enterococci accounting for 85% of episodes. Infective endocarditis (IE) is a serious disease with an incidence ranging from 30 to 100 ep
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9

Infective Endocarditis: Management in the Era of Intravascular Devices (Infectious Disease and Therapy). Informa Healthcare, 2007.

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10

Grisoli, Dominique, and Didier Raoult. Prevention and treatment of endocarditis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0161.

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Initially always lethal, the prognosis of infective endocarditis (IE) has been revolutionized by antibacterial therapy and valve surgery. Nevertheless, it remains one of the deadliest infectious diseases, with ≥30% of patients dying within a year of diagnosis. Its incidence has also remained stable at 25–50 cases per million per year, and results predominantly from a combination of bacteraemia and a predisposing cardiac condition, including endocardial lesions and/or intracardiac foreign material. While antibiotic prophylaxis is recommended by various learned societies to cover healthcare proc
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11

Alangaden, George J. Driveline Infection, Pocket Infection, or Endocarditis? Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199938568.003.0053.

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These case studies illustrate infections encountered in hospitals among patients with compromised immune systems. As a result of immunocompromise, the patients are vulnerable to common and uncommon infections. These cases are carefully chosen to reflect the most frequently encountered infections in the patient population, with an emphasis on illustrations and lucid presentations to explain state-of-the-art approaches in diagnosis and treatment. Common and uncommon presentations of infections are presented while the rare ones are not emphasized. The cases are written and edited by clinicians an
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12

Freedman, Lawrence R. Infective Endocarditis and Other Intravascular Infections. Springer London, Limited, 2012.

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13

Freedman, Lawrence R. Infective Endocarditis and Other Intravascular Infections. Springer, 2012.

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14

Siniawski, Henryk. Active Infective Aortic Valve Endocarditis with Infection Extension. Springer, 2008.

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15

Grossman, Jonah, Tanzila Shams, and Cathy Sila. Neurological Complications of Infective Endocarditis. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0167.

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Infective endocarditis is the fourth leading cause of life-threatening infections, accounting for 40,000 annual U.S. hospital admissions. Due to decline in rheumatic heart disease, a shift in causative organisms from viridans streptococci to S. aureus, Group D Streptococcus, and multidrug-resistant species has been observed. The spectrum of neurological complications ranges widely from cerebrovascular pathologies-including septic embolization, mycotic aneurysms, and intracerebral hemorrhages-to seizures, meningitis, cerebritis, and abscess. Transthoracic echocardiogram remains the standard for
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16

Török, M. Estée, Fiona J. Cooke, and Ed Moran. Cardiovascular infections. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199671328.003.0015.

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This chapter covers infective endocarditis characterized by infections of the endocardial surface of the heart, intravascular catheter-related infections, endovascular infections, myocarditis (which is an inflammatory disease of the myocardium), pericarditis (which is an inflammation of the pericardium), and mediastinitis (which is an infection involving the mediastinal structures).
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17

Drake, Sarah, and Jonathan Sandoe. Fungal cardiovascular infections. Edited by Christopher C. Kibbler, Richard Barton, Neil A. R. Gow, Susan Howell, Donna M. MacCallum, and Rohini J. Manuel. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198755388.003.0021.

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Fungal cardiovascular disease can broadly be divided into four groups: infective endocarditis (including implantable cardiac electronic devices), mycotic aneurysms, vascular graft infections, and intravascular catheter-related infections. These conditions are rare but are associated with significant morbidity and mortality, which may be in excess of 80% in certain groups of patients. Candida spp. and Aspergillus spp. account for the majority of these infections, but rare fungi may also be involved, particularly in infective endocarditis, where they are responsible for approximately 25% of case
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18

Shirodaria, Cheerag, and Jim Newton. Cardiac infection. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0108.

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This chapter discusses endocarditis and acute rheumatic fever, including definitions of the disease, etiology, typical symptoms, uncommon symptoms, demographics, natural history, complications, diagnostic approaches, other diagnoses that should be considered, prognosis, and treatment.
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19

Siniawski, Henryk. Active Infective Aortic Valve Endocarditis with Infection Extension: Clinical Features, Perioperative Echocardiographic Findings and Results of Surgical Treatment. Springer London, Limited, 2006.

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20

Harrison, Mark. Infection. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198765875.003.0056.

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This chapter describes the pathology of infection as it applies to Emergency Medicine, and in particular the Primary FRCEM examination. The chapter outlines the key details of the causes, pathological processes, and investigations of respiratory tracts infections (upper and lower including pneumonia), meningitis and encephalitis, myocarditis and endocarditis, hepatitis, gastroenteritis, urinary tract infection, STD, pelvic inflammatory disease, cellulitis, infection of bones and joints, AIDS, pyrexia of unknown origin, malaria, and fungal infection. This chapter is laid out exactly following t
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21

Veronica, Ameh. Gentamicin: Best Treatment for Bone Infections, Endocarditis, Pelvic Inflammatory Disease, Meningitis, Pneumonia, Urinary Tract Infections, and SEPSIS. Independently Published, 2019.

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22

Lawrence, T. P., and R. S. C. Kerr. Intracranial abscesses. Oxford University Press, 2010. http://dx.doi.org/10.1093/med/9780199204854.003.0241103.

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The incidence of intracranial abscess is low in countries where antimicrobial treatment for infections is widespread (e.g. 2–3 per million in the United Kingdom), but they remain frequent causes of space-occupying masses in developing countries.Aetiology—abscesses may be classified by (1) Route of transmission, including (a) direct—from a local source of infection, e.g. otitis media; (b) haematogenous—from a distant source, e.g. endocarditis, bronchiectasis, other septic lung conditions; or (c) following cranial surgery or fracture. (2) Microbiology—the commonest organisms are aerobic, anaerob
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23

Stone, Doctor Daniel. Clindamycin: The Super Action Antibiotics Used for the Treatment of a Wide Range of Bacterial Infections Such As Pelvic Inflammation, Middle Ear Infection, Strep Throat, Pneumonia and Endocarditic. Independently Published, 2019.

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24

Iung, Bernard. Epidemiology and physiopathology. Edited by Gilbert Habib. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198784906.003.0389.

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The incidence of infective endocarditis (IE) is estimated at between 15 and 60 cases per million inhabitants per year from population-based studies in industrialized countries. The presentation of IE has changed since patients are getting older and Staphylococcus is now becoming the microorganism most frequently responsible, which is partly attributable to healthcare-associated infections. The incidence of IE is higher in patients with heart valve prosthesis, previous endocarditis, and complex congenital heart disease. In developing countries, IE occurs in younger patients with a majority of r
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25

Wilson, John W., and Lynn L. Estes. Vancomycin Adult Dosing and Monitoring. Oxford University Press, 2012. http://dx.doi.org/10.1093/med/9780199797783.003.0017.

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(Note: Several vancomycin dosing and monitoring protocols exist; this is the one used at Mayo Clinic.)•Loading dose: Consider 20–30 mg/kg, especially in critically ill patients with serious infections such as meningitis, health care–associated pneumonia, or endocarditis.•Maintenance dose: Give 15–20 mg/kg based on actual body weight for most patients (20 mg/kg is reasonable when aiming for a trough range of 15–20 mcg/mL). Adjust based on serum levels. See also the following sections on hemodialysis and continuous renal replacement therapy....
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26

Evans, Charlotte, Anne Creaton, Marcus Kennedy, and Terry Martin, eds. Sepsis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198722168.003.0011.

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Sepsis is common and has been the focus of recent large-scale, multi-centre trials internationally. Mortality rates have improved, largely due to a focus on early identification, key interventions, and close monitoring. Setting goals and resuscitation targets coupled with frequent reassessment is the essence of modern sepsis care. Retrieval services bring the intensive care unit to the patient. Specific conditions such as infective endocarditis, central nervous system infections, respiratory, gastrointestinal, abdominal, obstetric, and necrotizing soft tissue sepsis require special considerati
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27

Active Infective Aortic Valve Endocarditis with Infection Extension: Clinical Features, Perioperative Echocardiographic Findings and Results of Surgical ... in der Herz-, Thorax- und Gefäßchirurgie). Steinkopff-Verlag Darmstadt, 2006.

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28

Marrie, Thomas J. Q fever. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780198570028.003.0018.

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Q fever is a wide spread illness affecting wild and domestic animals and man. The etiological agent Coxiella burnetii, has both a wild life and domestic animal cycle. In mammals, infection localizes to the endometrium and the mammary glands. The organism is reactivated during pregnancy reaching high concentrations in the placenta. At the time of parturition the organism is aerosolized. Inhalation of Coxiella burnetii by a susceptible animal results in Q fever. In man, Q fever may be acute (self limited febrile illness, pneumonia, hepatitis) or chronic (mostly endocarditis, but also osteomyelit
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29

Smith, Robert M. Other bacterial diseasesErysipeloid. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780198570028.003.0025.

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Erysipeloid is an acute bacterial infection usually causing acute localised cellulitis as a secondary infection of traumatised skin. It is caused by Erysipelothrix rhusiopathiae (insidiosa), a non-sporulating Gram-positive rod-shaped bacterium, ubiquitous in the environment. It is the cause of swine erysipelas and also a pathogen or commensal in a variety of wild and domestic birds, animal and marine species. Human infection primarily associated with occupational exposure to infected or contaminated animals or handling animal products and therefore is commoner in farmers, butchers and abattoir
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