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Littérature scientifique sur le sujet « Injectable in-situ forming hydrogel »

Auteur : Grafiati

Publié le 7 juin 2025

Mis à jour le 2 août 2025

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Articles de revues sur le sujet "Injectable in-situ forming hydrogel"

Chen, Ying, Xiaomin Wang, Yudong Huang, et al. "In Situ-Forming Cellulose/Albumin-Based Injectable Hydrogels for Localized Antitumor Therapy." Polymers 13, no. 23 (2021): 4221. http://dx.doi.org/10.3390/polym13234221.

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Injectable hydrogels, which are formed in situ by changing the external stimuli, have the unique characteristics of easy handling and minimal invasiveness, thus providing the advantage of bypass surgical operation and improving patient compliance. Using external temperature stimuli to realize the sol-to-gel transition when preparing injectable hydrogel is essential since the temperature is stable in vivo and controllable during ex vivo, although the hydrogels obtained possibly have low mechanical strength and stability. In this work, we designed an in situ fast-forming injectable cellulose/alb

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Ho, Emily, Anthony Lowman, and Michele Marcolongo. "In situ apatite forming injectable hydrogel." Journal of Biomedical Materials Research Part A 83A, no. 1 (2007): 249–56. http://dx.doi.org/10.1002/jbm.a.31457.

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Wang, Lixuan, Shiyan Dong, Yutong Liu, et al. "Fabrication of Injectable, Porous Hyaluronic Acid Hydrogel Based on an In-Situ Bubble-Forming Hydrogel Entrapment Process." Polymers 12, no. 5 (2020): 1138. http://dx.doi.org/10.3390/polym12051138.

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Injectable hydrogels have been widely applied in the field of regenerative medicine. However, current techniques for injectable hydrogels are facing a challenge when trying to generate a biomimetic, porous architecture that is well-acknowledged to facilitate cell behaviors. In this study, an injectable, interconnected, porous hyaluronic acid (HA) hydrogel based on an in-situ bubble self-generation and entrapment process was developed. Through an amide reaction between HA and cystamine dihydrochloride activated by EDC/NHS, CO2 bubbles were generated and were subsequently entrapped inside the su

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Mashaqbeh, Hadeia, Batool Al-Ghzawi, and Fatima BaniAmer. "Exploring the Formulation and Approaches of Injectable Hydrogels Utilizing Hyaluronic Acid in Biomedical Uses." Advances in Pharmacological and Pharmaceutical Sciences 2024 (May 27, 2024): 1–19. http://dx.doi.org/10.1155/2024/3869387.

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The characteristics of injectable hydrogels make them a prime contender for various biomedical applications. Hyaluronic acid is an essential component of the matrix surrounding the cells; moreover, hyaluronic acid’s structural and biochemical characteristics entice researchers to develop injectable hydrogels for various applications. However, due to its poor mechanical properties, several strategies are used to produce injectable hyaluronic acid hydrogel. This review summarizes published studies on the production of injectable hydrogels based on hyaluronic acid polysaccharide polymers and the

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Kwon, Jin Seon, So Mi Yoon, Doo Yeon Kwon, et al. "Injectable in situ-forming hydrogel for cartilage tissue engineering." Journal of Materials Chemistry B 1, no. 26 (2013): 3314. http://dx.doi.org/10.1039/c3tb20105h.

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Kocak, Fatma Z., Abdullah C. S. Talari, Muhammad Yar, and Ihtesham U. Rehman. "In-Situ Forming pH and Thermosensitive Injectable Hydrogels to Stimulate Angiogenesis: Potential Candidates for Fast Bone Regeneration Applications." International Journal of Molecular Sciences 21, no. 5 (2020): 1633. http://dx.doi.org/10.3390/ijms21051633.

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Biomaterials that promote angiogenesis are required for repair and regeneration of bone. In-situ formed injectable hydrogels functionalised with bioactive agents, facilitating angiogenesis have high demand for bone regeneration. In this study, pH and thermosensitive hydrogels based on chitosan (CS) and hydroxyapatite (HA) composite materials loaded with heparin (Hep) were investigated for their pro-angiogenic potential. Hydrogel formulations with varying Hep concentrations were prepared by sol–gel technique for these homogeneous solutions were neutralised with sodium bicarbonate (NaHCO3) at 4

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Turabee, Md Hasan, Thavasyappan Thambi, Huu Thuy Trang Duong, Ji Hoon Jeong, and Doo Sung Lee. "A pH- and temperature-responsive bioresorbable injectable hydrogel based on polypeptide block copolymers for the sustained delivery of proteins in vivo." Biomaterials Science 6, no. 3 (2018): 661–71. http://dx.doi.org/10.1039/c7bm00980a.

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Kim, Da Yeon, Hyeon Jin Ju, Jae Ho Kim, Sangdun Choi, and Moon Suk Kim. "Injectable in situ forming hydrogel gene depot to improve the therapeutic effect of STAT3 shRNA." Biomaterials Science 9, no. 12 (2021): 4459–72. http://dx.doi.org/10.1039/d1bm00624j.

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King, Jasmine L., Alain Valdivia, Shawn D. Hingtgen, and S. Rahima Benhabbour. "Injectable Tumoricidal Neural Stem Cell-Laden Hydrogel for Treatment of Glioblastoma Multiforme—An In Vivo Safety, Persistence, and Efficacy Study." Pharmaceutics 17, no. 1 (2024): 3. https://doi.org/10.3390/pharmaceutics17010003.

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Background/Objectives: Glioblastoma multiforme (GBM) is the most common high-grade primary brain cancer in adults. Despite efforts to advance treatment, GBM remains treatment resistant and inevitably progresses after first-line therapy. Induced neural stem cell (iNSC) therapy is a promising, personalized cell therapy approach that has been explored to circumvent challenges associated with the current GBM treatment. Methods: Herein, we developed a chitosan-based (CS) injectable, biodegradable, in situ forming thermo-responsive hydrogel as a cell delivery vehicle for the treatment of GBM. Tumori

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Zhang, Yajie, Hong Chen, Tingting Zhang, et al. "Fast-forming BMSC-encapsulating hydrogels through bioorthogonal reaction for osteogenic differentiation." Biomaterials Science 6, no. 10 (2018): 2578–81. http://dx.doi.org/10.1039/c8bm00689j.

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An injectable in situ fast-forming hydrogel was fabricated to encapsulate BMSCs for osteogenic differentiation through the inverse electron demand Diels–Alder click reaction between trans-cyclooctene-modified PEG and tetrazine-modified hyaluronic acid.

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Thèses sur le sujet "Injectable in-situ forming hydrogel"

Fisher, Paul. "Additives to Control Mechanical Properties and Drug Delivery of Injectable Polymeric Scaffolds." UKnowledge, 2014. http://uknowledge.uky.edu/cbme_etds/25.

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In situ forming implants (ISIs) are popular due to their ease of use and local drug delivery potential, but they suffer from high initial drug burst, and release behavior is tied closely to solvent exchange and polymer properties. Additionally, such systems are traditionally viewed purely as drug delivery devices rather than potential scaffold materials due to their poor mechanical properties and minimal porosity. The aim of this research was to develop an injectable ISI with drug release, mechanical, and microstructural properties controlled by micro- and nanoparticle additives. First, an inj

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Zheng, Zijie. "IN SITU FORMING PHOTODEGRADABLE HYDROGEL FOR CONTROLLED DELIVERY OF siRNA." Case Western Reserve University School of Graduate Studies / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1434560306.

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Gomes, Rodrigues Alexandre [Verfasser]. "Parenteral controlled drug delivery by novel direct injectable polymer (DIPO) : in situ forming implant / Alexandre Gomes Rodrigues." Halle, 2018. http://d-nb.info/1160514518/34.

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Yu, Hsing-Yi, and 余星億. "Injectable in Situ Forming pH-response Hydrogel as Delivery Vehicle for Cartilage Tissue Engineering." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/52535086530033622095.

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碩士 大同大學 材料工程學系(所) 101 Injectable hydrogels do not require a surgical procedure for implantation, and various therapeutic drugs can be incorporated through simple mixing, due the sol - gel state conversion characteristics. Preparation of pH-sensitive hygrogel in this study, the use of chitosan modified, prepared as a N,O carboxymethyl chitosan（NOCC）and hyaluronic acid （HA） derivative aldehyded hyaluronic acid （AHA）, via schiff base reaction. FTIR analysis, observation chitosan successfully modified N,O carboxymethyl chitosan（NOCC）. TNBSA analysis, determination of the degree of the

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Hsu, Pei Hsin, and 許沛新. "Using injectable in situ forming hydrogels as an intervertebral disc prosthesis." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/07513795118450633916.

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碩士 國立陽明大學 醫學工程研究所 100 Low back pain is a general chronic disease, one of the leading causes is nerve compression resulting from the degeneration and hernition of intervertebral disc. A microdiscectomy is typically performed for a herniated lumbar disc, but the surgery have problems like disc height loss and herniation recurrence. In this study, we use chitosan and hyaluronic acid to form in-situ injectable hydrogels by chemical modification. Hoping that we can fill up the surgical space, reduce disc height loss and decrease the risk of herniation recurrence by injecting in-situ for

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Costa, Joana Filipa Simões. "Natural based in-situ gelling hydrogels for prolonged drug delivery purposes." Master's thesis, 2020. http://hdl.handle.net/10316/94056.

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Dissertação de Mestrado Integrado em Engenharia Química apresentada à Faculdade de Ciências e Tecnologia The work described in this dissertation is a contribution to a financed research project between the University of Coimbra and a pharmaceutical company, which aims to design an injectable in situ forming drug delivery system for controlled and prolonged drug release. The primary goal of this work is the development of a hydrogel, part of that same system, from polysaccharides crosslinked by Michael addition. This objective can be further divided into specific steps to reach this goal, na

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Le, Renard Pol-Edern. "Injectable formulations forming an implant in situ as vehicle of silica microparticles embedding superparamagnetic iron oxide nanoparticles for the local, magnetically mediated hyperthermia treatment of solid tumors." Phd thesis, 2011. http://tel.archives-ouvertes.fr/tel-00709676.

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Cette thèse présente les travaux de développement de formulations injectables capables de se solidifier in situ, formant ainsi un implant piégeant des microparticules magnétiques en vue du traitement de tumeurs par induction magnétique d'une hyperthermie locale modérée. Nous exposons tout d'abord le contexte physique, biologique et clinique de l'hyperthermie comme traitement anticancéreux, particulièrement des modalités électromagnétiques. Les performances in vitro et in vivo des matériaux et formulations sont alors présentées. L'objet du chapitre suivant est la caractérisation des propriétés

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Vintiloiu, Anda. "In situ-forming injectable organogel implant for sustained release of rivastigmine." Thèse, 2007. http://hdl.handle.net/1866/15666.

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Luo, Li Jyuan, and 羅麗娟. "Development of Injectable Biodegradable In-Situ Forming Drug Delivery System for Glaucoma Therapy." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/ud488e.

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博士 長庚大學 化工與材料工程學系 106 Glaucoma is the second worldwide leading cause of blindness. Eye drops are frequently used to administer medication for ocular disease treatment. However, the main challenges with this type of dosage form include short precorneal residence time, poor corneal penetration, and low ocular bioavailability. Hence, to improve ocular bioavailability and pharmacological response, we used intracameral administration of drug containing thermo-sensitive biodegradable copolymer for glaucoma therapy. In chapter 2 and 3, these charpters focused on “Extended Drug Delivery Sy

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Hu, Ming-Hsiao, and 胡名孝. "In Situ Forming Oxidized Hyaluronic Acid/Adipic Acid Dihydrazide Hydrogel for Prevention of Epidural Fibrosis After Laminectomy." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/5j76z9.

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博士 國立臺灣大學 醫學工程學研究所 106 Spinal stenosis is a condition in which the spinal cord and the nerve roots are compressed by a number of pathologic factors, leading to symptoms such as pain, numbness, and weakness. The most common type of spinal stenosis is caused by degenerative arthritis of the spine. It is most commonly localized at the facet joints and ligamentum flavum. Many theories regarding the pathophysiology of spinal stenosis suggest a number of confluent mechanisms. The spinal cord can be directly compressed by bone osteophyte and ligamentous hypertrophy. Also, compression of l

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Chapitres de livres sur le sujet "Injectable in-situ forming hydrogel"

Park, Seung Hun, Yun Bae Ji, Joon Yeong Park, et al. "Injectable In Situ-Forming Hydrogels for Protein and Peptide Delivery." In Advances in Experimental Medicine and Biology. Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-3262-7_3.

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Deyhle, Hans, Georg Schulz, Bert Müller, et al. "Injectable In Situ-Forming Gel." In Encyclopedia of Nanotechnology. Springer Netherlands, 2012. http://dx.doi.org/10.1007/978-90-481-9751-4_100319.

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"Injectable In Situ Forming Gel." In Encyclopedia of Nanotechnology. Springer Netherlands, 2016. http://dx.doi.org/10.1007/978-94-017-9780-1_100427.

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Bharti, Deepti, Bikash Pradhan, Indranil Banerjee, and Kunal Pal. "Injectable In Situ Hydrogels for Regenerative Medicine Applications." In Functional Bio-based Materials for Regenerative Medicine: From Bench to Bedside (Part 1). BENTHAM SCIENCE PUBLISHERS, 2023. http://dx.doi.org/10.2174/9789815123104123010008.

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Regenerative medicine (RM) is a field of study that helps repair or restore native tissue function which has lost its functionality due to chronic diseases and trauma. The regeneration process can be promoted by constructing biomimetic systems, which can support cellular growth and proliferation. In this regard, the development of injectable hydrogels has gained enormous attention in recent times. An arrangement of cells and bioactive molecules in the three-dimensional extracellular matrix created by injectable gels is favorable for the regeneration of damaged tissues. Ideally, the injectable

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Vora, Lalitkumar K., B. H. Jaswanth Gowda, Shilpkala Gade, Anjali K. Pandya, and Raghu Raj Singh Thakur. "Injectable depot-forming hydrogels for long-acting drug delivery." In Hydrogels in Drug Delivery. Elsevier, 2025. https://doi.org/10.1016/b978-0-443-22017-3.00006-8.

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Bi, Xiangdong, and Aiye Liang. "In Situ‐Forming Cross‐linking Hydrogel Systems: Chemistry and Biomedical Applications." In Emerging Concepts in Analysis and Applications of Hydrogels. InTech, 2016. http://dx.doi.org/10.5772/63954.

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Actes de conférences sur le sujet "Injectable in-situ forming hydrogel"

Asadian, Mitra, Fariba Ganji, and Ladan Rashidi. "Sustained release drug delivery system based on MSNs dispersed in an injectable in-situ gelling chitosan hydrogel." In 2024 31st National and 9th International Iranian Conference on Biomedical Engineering (ICBME). IEEE, 2024. https://doi.org/10.1109/icbme64381.2024.10895086.

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Saraswathy, N., A. Manojkumar, M. Kamali, et al. "In situ forming alginate dialdehyde – Gelatin hydrogel containing cyclodextrin – curcumin accelerates in vivo wound healing." In THE 8TH ANNUAL INTERNATIONAL SEMINAR ON TRENDS IN SCIENCE AND SCIENCE EDUCATION (AISTSSE) 2021. AIP Publishing, 2022. http://dx.doi.org/10.1063/5.0108195.

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Usta, Aybala, Muhammad Rahman, and Ramazan Asmatulu. "Synthesis, Stability and Selection Study of Oil-in-Water Nanoemulsions Containing Nigella Sativa L. Essential Oil." In ASME 2017 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/imece2017-72205.

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Targeted drug delivery has a great importance in cancer treatment and is in interest of many scientists worldwide. Targeted drug delivery renders local treatment of cancerous cells possible without affecting healthy cells. Hydrogels are promising materials to be used in targeted drug delivery systems due to their biocompatible nature and injectable behaviors where they can be used to load drugs. However, considering that not all the drugs are water soluble, entrapment of some drugs into hydrogels is not practical in terms of poor drug solubility and burst drug release because of this. At this

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