Bibliographies thématiques / Intraclonal

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Littérature scientifique sur le sujet « Intraclonal »

Auteur : Grafiati
Publié le 1 avril 2023

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Articles de revues sur le sujet "Intraclonal"

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Gurrieri, Carmela, Peter McGuire, Hong Zan, et al. "Chronic Lymphocytic Leukemia B Cells Can Undergo Somatic Hypermutation and Intraclonal Immunoglobulin VHDJH Gene Diversification." Journal of Experimental Medicine 196, no. 5 (2002): 629–39. http://dx.doi.org/10.1084/jem.20011693.

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Chronic lymphocytic leukemia (CLL) arises from the clonal expansion of a CD5+ B lymphocyte that is thought not to undergo intraclonal diversification. Using VHDJH cDNA single strand conformation polymorphism analyses, we detected intraclonal mobility variants in 11 of 18 CLL cases. cDNA sequence analyses indicated that these variants represented unique point-mutations (1–35/patient). In nine cases, these mutations were unique to individual submembers of the CLL clone, although in two cases they occurred in a large percentage of the clonal submembers and genealogical trees could be identified.
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Volkheimer, Alicia D., J. Brice Weinberg, Bethany E. Beasley, et al. "Progressive immunoglobulin gene mutations in chronic lymphocytic leukemia: evidence for antigen-driven intraclonal diversification." Blood 109, no. 4 (2006): 1559–67. http://dx.doi.org/10.1182/blood-2006-05-020644.

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Abstract Somatic mutations of immunoglobulin genes characterize mature memory B cells, and intraclonal B-cell diversification is typically associated with expansion of B-cell clones with greater affinity for antigen (antigen drive). Evidence for a role of antigen in progression of intraclonal chronic lymphocytic leukemia (CLL) cell diversification in patients with mutated immunoglobulin genes has not been previously presented. We performed a single-cell analysis of immunoglobulin heavy and light chains in 6 patients with somatically mutated CLL-cell immunoglobulin genes and identified 2 patien
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Rawstron, Andy C., James A. L. Fenton, Marieth Plummer, et al. "Monoclonal B-Cell Lymphocytosis (MBL) and CLL Show Intraclonal Variation: Cases Classified as “Unmutated” Have the Greatest Clonal Diversity." Blood 108, no. 11 (2006): 30. http://dx.doi.org/10.1182/blood.v108.11.30.30.

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Abstract A monoclonal B-cell lymphocytosis (MBL) is detectable in approximately 3% of the general adult population. In most cases the abnormal cells have a phenotype and genotype that is indistinguishable from indolent CLL. Individuals presenting with an MBL count over 500 cells per microlitre progress to CLL requiring treatment at a rate of approximately 1% per year. The relationship between MBL and CLL therefore appears to be similar to that of MGUS and myeloma. Intraclonal variation (ICV) in the immunoglobulin heavy chain gene (IgVH) gene occurs in approximately half of MGUS patients but is
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Rajamanickam, C., and K. Rajmohan. "Intraclonal Variation in Musa (AAB) Palayankodan." International Journal of Current Microbiology and Applied Sciences 9, no. 6 (2020): 269–75. http://dx.doi.org/10.20546/ijcmas.2020.906.034.

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Zojer, Niklas, Heinz Ludwig, Michael Fiegl, Freda K. Stevenson, and Surinder S. Sahota. "Patterns of somatic mutations in VH genes reveal pathways of clonal transformation from MGUS to multiple myeloma." Blood 101, no. 10 (2003): 4137–39. http://dx.doi.org/10.1182/blood-2002-09-2825.

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AbstractMonoclonal gammopathy of undetermined significance (MGUS) can transform to multiple myeloma (MM). In myeloma, mutated VHgenes with sequence homogeneity reveal a postfollicular origin. Previously, some MGUS cases showed mutated VH genes with intraclonal variation, indicating an earlier stage of arrest. We investigated progression from 2 of 2 MGUS to MM, in which VH genes confirmed clonal evolution. In one MGUS case, intraclonal heterogeneity was evident, and transformation to myeloma occurred rapidly with apparent homogeneity in the emergent clone. However, residual MGUS-derived sequenc
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Bartholdy, Boris A., Xiahoua Wang, Xiao-Jie Yan, et al. "CLL intraclonal fractions exhibit established and recently acquired patterns of DNA methylation." Blood Advances 4, no. 5 (2020): 893–905. http://dx.doi.org/10.1182/bloodadvances.2019000817.

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Abstract Intraclonal subpopulations of circulating chronic lymphocytic leukemia (CLL) cells with different proliferative histories and reciprocal surface expression of CXCR4 and CD5 have been observed in the peripheral blood of CLL patients and named proliferative (PF), intermediate (IF), and resting (RF) cellular fractions. Here, we found that these intraclonal circulating fractions share persistent DNA methylation signatures largely associated with the mutation status of the immunoglobulin heavy chain locus (IGHV) and their origins from distinct stages of differentiation of antigen-experienc
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Hale, Anna L., J. Creighton Miller, K. Renganayaki, et al. "Suitability of AFLP and Microsatellite Marker Analysis for Discriminating Intraclonal Variants of the Potato Cultivar Russet Norkotah." Journal of the American Society for Horticultural Science 130, no. 4 (2005): 624–30. http://dx.doi.org/10.21273/jashs.130.4.624.

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The objective of this study was to differentiate six intraclonal variants of the potato (Solanum tuberosum L.) cultivar Russet Norkotah. One-hundred-twelve AFLP primer combinations producing 3755 bands and 79 microsatellite primers producing over 400 bands failed to identify any reproducible polymorphisms among the intraclonal variants and `Russet Norkotah'. The inability to detect differences between clones underscores the degree of genetic similarity between them, despite differences in phenotypic expression. This inability could be due to the tetraploid nature of the clones and/or to epigen
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Beke, Allan, Lucie Laplane, Julie Riviere, et al. "Multilayer intraclonal heterogeneity in chronic myelomonocytic leukemia." Haematologica 105, no. 1 (2019): 112–23. http://dx.doi.org/10.3324/haematol.2018.208488.

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Aarts, Wilhelmina M., Richard J. Bende, Eric J. Steenbergen, et al. "Variable heavy chain gene analysis of follicular lymphomas: correlation between heavy chain isotype expression and somatic mutation load." Blood 95, no. 9 (2000): 2922–29. http://dx.doi.org/10.1182/blood.v95.9.2922.009k38_2922_2929.

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The expansion of follicular lymphomas (FLs) resembles, both morphologically and functionally, normal germinal center B-cell growth. The tumor cells proliferate in networks of follicular dendritic cells and are believed to be capable of somatic hypermutation and isotype switching. To investigate the relation between somatic mutation and heavy chain isotype expression, we analyzed the variable heavy (VH) chain genes of 30 FL samples of different isotypes. The VH genes of the FLs were heavily mutated (29.3 mutations on average). In addition, isotype-switched lymphomas contained more somatic mutat
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Fagerström, T., and A. G. B. Poore. "Intraclonal Variation in Macroalgae: Causes and Evolutionary Consequences." Selection 1, no. 1-3 (2001): 123–34. http://dx.doi.org/10.1556/select.1.2000.1-3.12.

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Thèses sur le sujet "Intraclonal"

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Marie, Joan. "Intraclonal Morphological Plasticity within the Myzus persicae (Sulzer) Complex Related to Host Plant and Temperature." Thesis, Virginia Tech, 2004. http://hdl.handle.net/10919/33305.

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Blackman (1987) used life cycle and morphology to separate Myzus nicotianae Blackman, a tobacco-feeding species of aphid, from Myzus persicae (Sulzer). In the present study, the first objective was to investigate the influence of temperature and host plant on the morphology of M. nicotianae and M. persicae. The second objective was to assess Blackman¡¦s 1987 key to Myzus for separating tobacco and non-tobacco originating morphs under different environmental conditions. Four host plants were used: tobacco, turnip, pepper, and okra, and three temperatures, 15â aC, 20â aC, and 25â aC.
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Martin, Patricia. "La génération d'un polymorphisme génétique intraclonal est modulée pendant la différenciation chez Streptomyces ambofaciens ATCC23877." Nancy 1, 2000. http://www.theses.fr/2000NAN10110.

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Chez S. Ambofaciens, la pigmentation des colonies est un caractère instable. Ce phénomène se traduit par la production de 4 types de colonie dans la descendance d’une colonie pigmentée dite sauvage (WT) : des colonies pigmentées (Pig+), des colonies dépigmentées (Pig-col), des colonies pigmentées à secteur dépigmenté (Pig+sec) ou à papilles dépigmentées (Pig+pap). Des réarrangements (délétion et/ou amplification) ont été observés dans les mutants Pig-col. Un polymorphisme génétique important a été révélé au sein de 12 sous-clones WT, tant au niveau phénotypique (variation des fréquences de Pig
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Brioli, Annamaria <1982&gt. "The impact of intraclonal heterogeneity on the outcomes of Multiple Myeloma patients treated with new drugs." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amsdottorato.unibo.it/6779/1/Brioli_Annamaria_tesi.pdf.

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Understanding the biology of Multiple Myeloma (MM) is of primary importance in the struggle to achieve a cure for this yet incurable neoplasm. A better knowledge of the mechanism underlying the development of MM can guide us in the development of new treatment strategies. Studies both on solid and haematological tumours have shown that cancer comprises a collection of related but subtly different clones, a feature that has been termed “intra-clonal heterogeneity”. This intra-clonal heterogeneity is likely, from a “Darwinian” natural selection perspective, to be the essential substrate for canc
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Brioli, Annamaria <1982&gt. "The impact of intraclonal heterogeneity on the outcomes of Multiple Myeloma patients treated with new drugs." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amsdottorato.unibo.it/6779/.

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Understanding the biology of Multiple Myeloma (MM) is of primary importance in the struggle to achieve a cure for this yet incurable neoplasm. A better knowledge of the mechanism underlying the development of MM can guide us in the development of new treatment strategies. Studies both on solid and haematological tumours have shown that cancer comprises a collection of related but subtly different clones, a feature that has been termed “intra-clonal heterogeneity”. This intra-clonal heterogeneity is likely, from a “Darwinian” natural selection perspective, to be the essential substrate for canc
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Sutton, Lesley Ann. "Molecular and Genetic Evidence for Antigen Selection in the Pathogenesis of Chronic Lymphocytic Leukemia." Doctoral thesis, Uppsala universitet, Hematologi och immunologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-181602.

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Antigens play a critical role in the development of chronic lymphocytic leukemia (CLL) by binding to and stimulating leukemic precursor cells at some point during CLL ontogeny. Nevertheless, much remains unknown and further studies are necessary before an accurate model of antigen-drive can be ascertained. In this context, intraclonal diversification (ID) analysis of immunoglobulin (IG) genes could shed light on whether antigen involvement is restricted to the malignant transformation phase or if the triggering antigen(s) continuously stimulates the CLL clone. Hence, in Paper I we conducted a
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Vorwerk, Sonja. "Molecular evidence of intraclonal variation and implications for adaptational traits of grape phylloxera populations (Daktulosphaira vitifoliae, Fitch)." [S.l. : s.n.], 2007. http://nbn-resolving.de/urn:nbn:de:bsz:100-opus-2086.

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Jacobs, Claudia. "Untersuchung entfernt lokalisierter Gewebeproben kutaner B-Zell-Lymphome auf intraklonale Diversität mit der Einzel-Zell-PCR-Technik." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2000. http://dx.doi.org/10.18452/14571.

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Zusammenfassung Die molekularbiologischen Untersuchungen der variablen Genabschnitte der Immunglobulingene von Lymphomzellen zweier Patienten mit kutanen B-Zell-Lymphomen wurden in der vorliegenden Arbeit mittels Einzel-Zell-PCR-Technik durchgeführt. Die erfolgte Analyse galt bevorzugt dem Aspekt der intraklonalen Diversität. Die Sequenzanalysen der Ig-Gene für die leichte Kette aus den insgesamt 100 untersuchten Tumorzellen des Patienten WS ergaben, daß zwischen den Zellen aus drei voneinander entfernt lokalisierten Gewebeproben intraklonale Diversität vorlag. Aufgrund der Mut
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Koyo, Jean-Prosper. "Bouturage et variabilité morphogénétique de clones de Terminalia superba Engler et Diels ou Limba du Sud-Congo." Paris 11, 1985. http://www.theses.fr/1985PA112011.

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Les études d’amélioration génétique du Terminalia superba par voie asexuée ont été entreprises au CONGO, dans le cadre d’un projet de reboisement industriel de cette espèce. Une centaine de Limba d’élite sélectionnés dans les forêts du sud du Congo, ont été clonés et font l’objet depuis 1976 de plusieurs expérimentations et observations. Si actuellement, le bouturage est acquis et la croissance des clones encourageante, il n’en est pas de même de la réjuvénilisation qui ne semble pas encore satisfaisante, en particulier pour les caractères de branchaison. En conclusion, nous suggérons un schém
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Pires, Ana Marta Costa. "Free light chain: a marker of disesase and intraclonal heterogeneity indicator in intact immunoglobulin multiple myeloma." Master's thesis, 2019. https://hdl.handle.net/10216/124600.

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Pires, Ana Marta Costa. "Free light chain: a marker of disesase and intraclonal heterogeneity indicator in intact immunoglobulin multiple myeloma." Dissertação, 2019. https://hdl.handle.net/10216/124600.

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Chapitres de livres sur le sujet "Intraclonal"

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Rainey, Paul B., Ian P. Thompson, and E. Richard Moxon. "Intraclonal Polymorphism in Bacteria." In Advances in Microbial Ecology. Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-2858-6_6.

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Actes de conférences sur le sujet "Intraclonal"

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Jakubikova, Jana, Danka Cholujova, Teru Hideshima, et al. "Abstract 2004: Phenotypic and molecular characterization of inter- and intraclonal heterogeneity in multiple myeloma and Waldenstrom macroglobulinemia." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-2004.

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