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Articles de revues sur le sujet « Introduction an inhalation way –the nebulizer »

Auteur : Grafiati

Publié le 7 juin 2025

Mis à jour le 2 août 2025

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1

Dorman, Sandra C., Kaylyn M. Sutcliffe, Jacques Abourbih, and Stacey A. Ritz. "Inhalation of Nebulized Diesel Particulate Matter: A Safety Trial in Healthy Humans." Journal of Respiratory Medicine 2014 (February 4, 2014): 1–9. http://dx.doi.org/10.1155/2014/797050.

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Diesel particulate matter (DPM) has adverse health effects. Examining the underlying pathophysiological mechanisms would be facilitated by the introduction of an exposure method that is safe, portable, and cost-effective. The purpose of this study was to establish a novel method to study DPM exposure via nebulization and an inhalation dose that was safe, yet capable of eliciting an inflammatory response. Ten participants enrolled in this nonblinded, nonrandomized study. Subjects inhaled nebulized 0.9% saline and increasing doses of DPM suspended in 0.9% saline (75, 150, and 300 μg) in a sequen

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Gautam, Anshoo, Deeksha Singh, Peeyush Shrivastava, and R. Vijayaraghavan. "Acute inhalation toxicity study of n-heneicosane and its combination with diflubenzuron: An attracticide of Aedes aegypti." Toxicology and Industrial Health 34, no. 10 (2018): 703–13. http://dx.doi.org/10.1177/0748233718774987.

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Objective: Combination of an oviposition pheromone and an insect growth regulator for the control of vectors is an effective approach. There is a need for toxicological evaluation before its introduction. The present study evaluates the acute inhalation toxicity of n-heneicosane and its combination with diflubenzuron in a head-only inhalation exposure chamber made of glass. Materials and methods: A head-only inhalation exposure chamber made of glass (volume: 3.5 l) was used for exposing four rats at a time. A glass nebulizer was used for aerosolization of n-heneicosane and its combination with

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Averyanov, A. V., A. G. Konoplyannikov, F. G. Zabozlaev, et al. "Effects of inhalation and intravenous administration of allogeneic mesenchymal bone marrow stromal cells in a bleomycin-induced model of pulmonary fibrosis in rabbits." Russian Journal of Transplantology and Artificial Organs 19, no. 4 (2018): 88–96. http://dx.doi.org/10.15825/1995-1191-2017-4-88-96.

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Aim:to perform a comparative analysis of the efﬁ cacy of the inhaled and intravenous delivery of equivalent doses of bone marrow mesenchymal stem cells (BMMSCs) in rabbits according to the standard model of bleomycin pulmonary ﬁ brosis.Materials and methods.After bronchoscopic instillation of bleomycin, 5 rabbits received intravenous transplantation of 2 × 106 allogeneic BMMSCs, other 5 rabbits – 2 × 107 MSCs inhaled via compressor nebulizer; control healthy and bleomycin group included 5 animals each.Results.Both groups treated with BMMSCs had a signiﬁ cantly lower Ashcroft ﬁ brosis index tha

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Voronkova, O. O., N. A. Nikolaeva, G. B. Abdullaeva, O. E. Buyanova, E. F. Rogova, and Yu N. Belenkov. "The dynamics of respiratory changes on the background of inhalation treatment with tauractant in patients in the post-covid period." Meditsinskiy sovet = Medical Council, no. 9 (June 22, 2025): 91–96. https://doi.org/10.21518/ms2025-229.

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Introduction. Pulmonary surfactant is a key component of the respiratory system that ensures the stability of the alveoli by reducing surface tension, preventing collapse of the respiratory tract and protecting against infections. Its dysfunction is observed in severe respiratory diseases, including COVID-19, ARDS, pneumonia, COPD and bronchial asthma. Of particular interest is the inhalation use of exogenous forms of surfactant not only in acute COVID-19, but also in the post-covid period.Aim. The aim of the study is to evaluate the effectiveness of a course of inhalation of tauractant emulsi

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Chernusky, VG, NN Popov, OL Govalenkova, AV Letyago, VL Kashina-Yarmak, and TV Evdokimova. "ANTIMICROBIAL PROPERTIES «LIPIN» INHALATION USE IN CHILDREN WITH ASTHMA." Annals of Mechnikov Institute, no. 2 (November 18, 2016): 69–74. https://doi.org/10.5281/zenodo.167498.

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Introduction. Problems of modern pharmacotherapy of bronchial asthma (BA) in children is largely reduced to the establishment of effective dosage forms that provide the delivery of drugs in the bronchopulmonary system without affecting other organ systems. A promising area in addressing the causal treatment of asthma in children is the use of the formulation «Lipin», which is a liposome, arising by self-assembly of amphiphilic lipid complexes. Material & methods. The study of antimicrobial properties «Lipin» on microorganisms isolated from sputum in 135 children are hospitalized in the pul

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Chernusky, VG, NN Popov, OL Govalenkova, AV Letyago, VL Kashina-Yarmak, and TV Evdokimova. "ANTIMICROBIAL PROPERTIES «LIPIN» INHALATION USE IN CHILDREN WITH ASTHMA." Annals of Mechnikov Institute, no. 2 (November 18, 2016): 69–74. https://doi.org/10.5281/zenodo.167499.

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Introduction. Problems of modern pharmacotherapy of bronchial asthma (BA) in children is largely reduced to the establishment of effective dosage forms that provide the delivery of drugs in the bronchopulmonary system without affecting other organ systems. A promising area in addressing the causal treatment of asthma in children is the use of the formulation «Lipin», which is a liposome, arising by self-assembly of amphiphilic lipid complexes. Material & methods. The study of antimicrobial properties «Lipin» on microorganisms isolated from sputum in 135 children are hospitalized in the pul

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Miyata, Yoshito, Shin Ohta, Akihiko Tanaka, et al. "The Effect of Bronchoconstriction by Methacholine Inhalation in a Murine Model of Asthma." International Archives of Allergy and Immunology 181, no. 12 (2020): 897–907. http://dx.doi.org/10.1159/000509606.

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<b><i>Introduction:</i></b> Bronchoconstriction was recently shown to cause airway remodeling and induce allergic airway inflammation in asthma. However, the mechanisms how mechanical stress via bronchoconstriction could induce airway inflammation and remodeling remain unclear. <b><i>Objective:</i></b> We investigated the effect of bronchoconstriction induced by methacholine inhalation in a murine model of asthma. <b><i>Methods:</i></b> BALB/c female mice were sensitized and challenged with ovalbumin (OVA), followed by tre

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Lee, Donghyun, Sung Su Kim, Shin Seong, Wonjun Cho та Hyejin Yu. "Stage IV Wilms Tumor Treated by Korean Medicine, Hyperthermia and Thymosin-α1: A Case Report". Case Reports in Oncology 9, № 1 (2016): 119–25. http://dx.doi.org/10.1159/000443724.

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Introduction: Wilms tumor is one of general solid cancers that occur in children, which carries a death rate of 7-8 in a million. The cure rate of Wilms tumor in the recent 30 years has dramatically been improved, but a proper remedy is still not prepared enough in terms of application in tumor therapy upon recurrence after radiotherapy, surgery and chemotherapy. We present an integrative medical remedy - hyperthermia and thymosin-α1 treatment focused on herbal remedy - since there have been cases in which this remedy contributed to remission in the liver-transferred part in the 4th phase of W

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Lauzon, Megan, Caroline Ko, Sherman Lau, et al. "587 Pharmacy Residents Have a Significant Impact on Process Improvement at Verified Burn Center." Journal of Burn Care & Research 45, Supplement_1 (2024): 174. http://dx.doi.org/10.1093/jbcr/irae036.221.

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Abstract Introduction Quality and process improvement are vital for burn centers to maintain patient safety, systematically review complications, and adopt new practices involving technology, medications, and staff development. The pharmacy is involved in every facet of burn care from the intensive care unit to the operating room. Pharmacy residents participate in quality and process improvement projects during their training, but little published data exists on how pharmacy residents contribute to overall process improvement in a verified burn center. Methods Postgraduate Year-Two (PGY2) phar

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Sims, Brittany, Will Risinger, Victoria Hammond, Chinweotuto Uma, and Keeven David. "888 Nebulized Heparin and N-Acetylcysteine Do Not Improve Outcomes of Intubated Burn Patients with Inhalation Injuries." Journal of Burn Care & Research 46, Supplement_1 (2025): S319—S320. https://doi.org/10.1093/jbcr/iraf019.419.

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Abstract Introduction Inhalational injury significantly alters the clinical course of burn patients. In addition to increasing the volume of fluid required for adequate resuscitation, inhalation injury places patients at risk of prolonged mechanical ventilation, pneumonia, and acute respiratory distress syndrome. To combat the deleterious effects of inhalational trauma, therapeutic strategies consisting of nebulized medications have been used. Nebulized heparin attenuates pulmonary edema and reduces formation of intraluminal fibrin. NAC provides anti-inflammatory benefits in addition to a muco

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Haidl, Peter. "Inhalative Antibiotika-Behandlung von Patienten mit chronischer Pseudomonas-aeruginosa-Infektion." Kompass Pneumologie 7, no. 4 (2019): 196–97. http://dx.doi.org/10.1159/000501248.

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Background: Inhaled antibiotics allow the delivery of higher drug concentrations at the site of infection without the systemic adverse effects observed with the use of parenteral or oral antibiotics. These antibiotics have shown to decrease the number of exacerbations, reduce bacterial load or improve pulmonary function in several chronic respiratory conditions. Objectives: The aim of this study was to describe changes in the bacteriology of sputum in patients with chronic bronchial infection with Pseudomonas aeruginosa treated with nebulized colistin. Material and Methods: All patients with c

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Titova, O. N., N. A. Kuzubova, D. B. Skliarova, A. L. Aleksandrov, and N. V. Egorova. "The effectiveness of combination of 7% hypertonic saline and 0.1% natrii hyaluronas in patients with chronic obstructive pulmonary disease who have suffered a new coronavirus infection." Meditsinskiy sovet = Medical Council, no. 16 (October 29, 2021): 85–91. http://dx.doi.org/10.21518/2079-701x-2021-16-85-91.

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Introduction. New coronavirus infection (COVID-19) contributes to the aggravation of respiratory symptoms in patients with COPD, including affecting the intensity and nature of cough. Hypertonic solution (HS) has a positive effect on the rheological properties of sputum and mucociliary clearance. However, there are no studies in the available literature on the use of HS in patients who have undergone COVID-19.Goal. To evaluate the effect of the combination of 7% hypertonic saline and 0.1% natrii hyaluronas on the intensity and productive nature of cough in patients with COPD who have undergone

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Renata, Cristina de Angelo Calsaverini Leal. "Inhalation Devices: Various forms of administration for Therapeutic Optimization." Open Journal of Asthma 1, no. 1 (2017): 037–44. https://doi.org/10.17352/oja.000006.

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<strong>Introduction: </strong>Aerosol therapy consists of spraying liquid particles suspended for therapeutic purposes in the respiratory tract. With direct absorption and deposition at the lung level, avoiding side effects and presenting fast response time. Several factors influence the drug action, such as size, particle movement, ventilatory fl ow, pulmonary expansion, anatomy, respiratory mechanics and the nebulizer and patient interface. The therapeutic optimization depends on the type of nebulizer differentiating itself by the physical principle that generates the mist.

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Touw, DJ, RW Brimicombe, ME Hodson, HG Heijerman, and W. Bakker. "Inhalation of antibiotics in cystic fibrosis." European Respiratory Journal 8, no. 9 (1995): 1594–604. http://dx.doi.org/10.1183/09031936.95.08091594.

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Aerosol administration of antipseudomonal antibiotics is commonly used in cystic fibrosis. However, its contribution to the improvement of lung function, infection and quality of life is not well-established. All articles published from 1965 until the present time concerning the inhalation of antibiotics in cystic fibrosis were collected by computerized literature search and analysed. Effective aerosol delivery is compromised by nebulizers with limited capacity to produce particles in the respirable range. Twelve studies concerning maintenance treatment were published. Four uncontrolled studie

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Yahia, Adalah, Sarah Jaszcz, Marco R. Scipione, Lester Laddaran, and Michael White. "570 Efficacy of Nebulized Heparin in Inhalation Injury: 12 Years Single Center Experience." Journal of Burn Care & Research 46, Supplement_1 (2025): S156. https://doi.org/10.1093/jbcr/iraf019.199.

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Abstract Introduction Inhalation injury is a significant contributor to morbidity and mortality in burn patients. Nebulized heparin is hypothesized to reduce fibrin casts and lung obstruction, potentially improving clinical outcomes such as time on mechanical ventilation, mortality, and pneumonia rates. Current evidence is limited to small retrospective studies, with conflicting results regarding the efficacy of nebulized heparin. Methods This retrospective cohort study reviews 12 years of experience at a single Burn Center treating inhalation injuries. Patients who received nebulized heparin

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Chin, Theresa L., Rita Frerk, Victor C. Joe, and Nicole O. Bernal. "19 Nebulized Tobramycin is Associated with Decreased Pneumonia After Inhalation Injury." Journal of Burn Care & Research 42, Supplement_1 (2021): S18. http://dx.doi.org/10.1093/jbcr/irab032.024.

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Abstract Introduction Management of inhalation injury is largely supportive and consists primarily of mechanical ventilation, bronchodilators, muscarinic receptor antagonists, and inhaled mucolytics and anticoagulants. Patients with inhalation injury are at high risk for pneumonia. Nebulized tobramycin is well supported in the use of chronic lung infections in patients with cystic fibrosis (CF). We hypothesize that after inhalation injury patients empirically treated with nebulized tobramycin (NT) have decreased incidence of pneumonia. Methods A protocol for a standardized 7-day course of nebu

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Ignatova, G. L., and V. N. Antonov. "Nebulizer therapy for lung diseases." Meditsinskiy sovet = Medical Council, no. 11 (August 8, 2020): 102–6. http://dx.doi.org/10.21518/2079-701x-2020-11-102-106.

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The article presents data on the use of nebulizer therapy for major respiratory diseases: chronic obstructive pulmonary disease (COPD), bronchial asthma. The conditions for using aerosol-producing devices for new COVID-19 coronavirus infection, in the hospital and at home are also given. Historical aspects of the creation and use of devices for nebulizer therapy are considered. A differentiated approach is given when choosing an inhaler depending on the clinical situation, taking into account the need to use devices with a high level of precipitated fine particle fraction of the pharmaceutical

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Noseda, A., and JC Yernault. "Sympathomimetics in acute severe asthma: inhaled or parenteral, nebulizer or spacer?" European Respiratory Journal 2, no. 4 (1989): 377–82. http://dx.doi.org/10.1183/09031936.93.02040377.

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It is accepted today that all patients with acute asthma should be treated with a sympathomimetic, irrespective of previous therapy. This short review addresses the question of the optimal mode of administration of these drugs in acute severe asthma. Inhaled sympathomimetics are as effective as subcutaneous adrenaline, or intravenous salbutamol or terbutaline, and, as they produce fewer side-effects, are recommended as the best mode of administration. However, self-medication with a ready to use subcutaneous preparation may be indicated in those patients prone to very abrupt attacks. The conve

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Zavala, Sarah, Ibrahim Chowdhury, Kyle Moomey, and Yuk Ming Liu. "514 Duration of Nebulized Heparin for Inhalation Injury." Journal of Burn Care & Research 42, Supplement_1 (2021): S104. http://dx.doi.org/10.1093/jbcr/irab032.165.

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Abstract Introduction Inhalation injuries (IHI) are a major source of morbidity and mortality in burn patients. The purpose of this study is to evaluate short versus long duration of nebulized heparin in IHI and its effect on ventilator-free days. Methods This was a single-center retrospective analysis of adult patients with bronchoscopy-confirmed IHI admitted to a large academic medical center with an American Burn Association-verified Burn Unit between March 2013 and March 2018, who received nebulized heparin 10,000 units every four hours for three days or until the patient no longer had car

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Averyanov, A. V., A. G. Konoplyannikov, F. G. Zabozlaev, et al. "Comparative study of the effects of mesenchymal stem cells with different delivery methods in an experimental model of lung fibrosis." Journal of Clinical Practice 9, no. 4 (2018): 4–14. http://dx.doi.org/10.17816/clinpract944-14.

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Background: Transplantation of mesenchymal stem cells (MSCs) is one of the most promising directions in the treatment of idiopathic pulmonary fibrosis. In experimental small animal studies, intravenous and endobronchial (installation) techniques are used for the cell preparation delivery, while in humans inhalation of drugs is the simplest and most available method. Aim: The aim of the study was to determine the optimal type of a nebulizer for viability of MSCs during nebulization, followed by a comparison of the effects of inhalation and intravenous delivery methods in a standard model

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Song, Cherry, Michael Marano, Robin Lee, et al. "954 Hydrofluoric Acid Fumes Associated with Electric Vehicle Lithium Ion Battery Fires." Journal of Burn Care & Research 46, Supplement_1 (2025): S365. https://doi.org/10.1093/jbcr/iraf019.485.

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Abstract Introduction Lithium-ion batteries (LIB) are a common technology used in portable electronics, electric vehicles, and energy storage solutions. Electric cars and e-bikes have increased in popularity and demand, with a projection to grow in the future. One of the most recognized safety issues for LIB is thermal runaway. This process involves a rapid self-heating mechanism driven by internal exothermic reactions, leading to cell destruction and the release of toxic flammable gases, which poses a high risk of fire or explosion. The process may be initiated by disruption of battery integr

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Cox, Courtney, Allyson M. McIntire, Kimberly Bolton, et al. "83 Multicenter Evaluation of the Use of Nebulized Heparin for Inhalation Injury (HIHI2 Study)." Journal of Burn Care & Research 41, Supplement_1 (2020): S53—S54. http://dx.doi.org/10.1093/jbcr/iraa024.087.

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Abstract Introduction Inhalation injury (IHI) causes significant morbidity and mortality secondary to local compromise of the respiratory system as well as systemic effects limiting perfusion and oxygenation. Nebulized heparin reduces fibrin cast formation and duration of mechanical ventilation in patients with IHI. To date, no study has compared both dosing strategies of 5,000 and 10,000 units to a matched control group. The objective of this study is to compare heparin 5,000 and 10,000 units to a historical control and determine which dosing strategy improves lung function and decreases mech

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Rzepka-Wrona, Patrycja, Szymon Skoczynski, Dawid Wrona, and Adam Barczyk. "Inhalation Techniques Used in Patients with Respiratory Failure Treated with Noninvasive Mechanical Ventilation." Canadian Respiratory Journal 2018 (June 3, 2018): 1–8. http://dx.doi.org/10.1155/2018/8959370.

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The administration of aerosolized medication is a basic therapy for patients with numerous respiratory tract diseases, including obstructive airway diseases (OADs), cystic fibrosis (CF), and infectious airway diseases. The management and care for patients requiring mechanical ventilation remains one of the greatest challenges for medical practitioners, both in intensive care units (ICUs) and pulmonology wards. Aerosol therapy is often necessary for patients receiving noninvasive ventilation (NIV), which may be stopped for the time of drug delivery and administered through a metered-dose inhale

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Ehtezazi, Touraj. "The Potential Use of Cyclosporine Ultrafine Solution Pressurised Metered- Dose Inhaler in the Treatment of COVID-19 Patients." Recent Advances in Drug Delivery and Formulation 16, no. 1 (2022): 2–14. http://dx.doi.org/10.2174/2772574x12666211122113318.

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Introduction: Serious COVID-19 respiratory problems start when the virus reaches the alveolar level, where type II cells get infected and die. Therefore, virus inhibition at the alveolar level would help preventing these respiratory complications. Method: A literature search was conducted to collect physicochemical properties of small molecule compounds that could be used for the COVID-19 treatment. Compounds with low melting points were selected along with those soluble in ethanol, hydrogen-bond donors, and acceptors. Results : There are severe acute respiratory syndrome coronavirus inhibitor

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Dobrianskyi, D. V., G. L. Gumeniuk, P. F. Dudka, I. P. Tarchenko, А. О. Dorokhova, and К. О. Kozhevnikova. "Selection of the Optimal Strategy for Mucolytic Therapy of Respiratory Diseases." Asthma and allergy 2023, no. 2 (2023): 47–55. http://dx.doi.org/10.31655/2307-3373-2023-2-47-55.

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Abstract. Lung health mostly depends on effective mucociliary clearance. Many lung diseases have a classic pathogenetic triad (hypercrinia, dyscrinia, mucostasis) – when thick and viscous mucus is difficult to secrete and this can lead to an infection, progressive inflammation, as well as impaired airway patency. Today, the arsenal of drugs that reduce the density of sputum, improve mucociliary clearance and promote sputum release has significantly increased. Thus, medical professionals face the issue of choosing the optimal drug or their combination, as well as the way of drug management, in

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Elkins, Mark R., Sandra D. Anderson, Clare P. Perry, Evangelia Daviskas, and Brett Charlton. "Inspiratory Flows and Volumes in Subjects with Non-CF Bronchiectasis Using a New Dry Powder Inhaler Device." Open Respiratory Medicine Journal 8, no. 1 (2014): 8–13. http://dx.doi.org/10.2174/1874306401408010008.

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Introduction: Drug inhalation via a dry-powder inhaler (DPI) is a convenient, time efficient alternative to nebulizers in the treatment of cystic fibrosis (CF) or non-CF bronchiectasis. Efficient drug administration via DPIs depends on the device resistance and adequate (≥45L/min) inspiratory flows and volumes generated by individuals. Drypowder mannitol is delivered using a RS01 breath-actuated device developed by Plastiape, for Pharmaxis. The study aim was to determine in vivo if non-CF bronchiectasis patients’ inspiratory flows and volumes are adequate to use the RS01 DPI device. Materials

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Antolick, Ashley, Lindsey Ouellette, Bryan Judge, Brad Riley, and JS Jones. "Accidental Chlorine Gas Exposure in a Pediatric Patient: A Case Report." Clinical Practice and Cases in Emergency Medicine 4, no. 2 (2020): 205–7. http://dx.doi.org/10.5811/cpcem.2020.3.46746.

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Introduction: Chlorine gas is a known irritant of the respiratory tract, which may cause damage to various systems depending on time of exposure and concentration of the gas. Current treatments are mainly supportive. While no definitive studies have been completed to date, it has been noted that treatment with a sodium bicarbonate solution via nebulizer may lead to improved outcomes for patients dealing with chlorine gas exposure. Case Report: We present a case of a nine-year-old child arriving at the emergency department after exposure to chlorine gas. Complete recovery from his symptoms occu

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Semigolovskii, N. Yu, S. O. Mazurenko, I. S. Simutis, L. G. Ermolaeva, and S. N. Semigolovskii. "Experience in the treatment of patients with pulmonary embolism using apixaban and ultrasound inhalations of unfractionated heparin." Meditsinskiy sovet = Medical Council, no. 6 (May 3, 2023): 28–34. http://dx.doi.org/10.21518/ms2022-048.

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Introduction. Pulmonary embolism (PE) is one of the leading causes of death even in hospitalized patients. The standard treatment results are disappointing. Since 2004, we have tested a new method for the treatment of hemodynamically insignificant PE (own patent RU2224525C1) by using unfractionated heparin (UFH) in ultrasound inhalations with a nebulizer, since 2014 – in combination with apixaban. Aim. To improve the treatment of PE. Materials and methods. The hospital mortality rate of 713 patients of the cardiac intensive care unit with hemodynamically insignificant PE (from January 1, 2002

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Elkins, Mark R., Philip Robinson, Sandra D. Anderson, Clare P. Perry, Evangelia Daviskas, and Brett Charlton. "Inspiratory Flows and Volumes in Subjects with Cystic Fibrosis Using a New Dry Powder Inhaler Device." Open Respiratory Medicine Journal 8, no. 1 (2014): 1–7. http://dx.doi.org/10.2174/1874306401408010001.

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Introduction: Drug inhalation via a dry-powder inhaler (DPI) is a convenient, time efficient alternative to nebulizers in the treatment of cystic fibrosis (CF). Efficient drug administration via DPIs depends on the device resistance and adequate (≥ 45L/min) inspiratory flows and volumes generated by individuals. Dry-powder mannitol is delivered using a RS01 breath-actuated device developed by Plastiape, for Pharmaxis. The study aim was to determine in vivo if CF patients’ inspiratory flows and volumes are adequate to use the RS01 DPI device. Materials and Methodology: An open, non-intervention

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Jones, Kristen M., Edward Liao, Kathy Hohneker, et al. "Pharmacokinetics of Amiloride after Inhalation and Oral Administration in Adolescents and Adults with Cystic Fibrosis." Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 17, no. 2 (1997): 263–70. http://dx.doi.org/10.1002/j.1875-9114.1997.tb03708.x.

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Study Objective. To compare the pharmacokinetics and systemic exposure of nebulized and oral amiloride in adolescents and adults with mild to moderate cystic fibrosis (CF).Design. Open‐label, randomized, two‐way crossover, single‐dose pharmacokinetic study.Setting. University hospital clinical research unit.Patients. Nine adolescents and 10 adults with mild to moderate CF (forced expiratory volume in 1 sec > 50% predicted, Brasfield score ≥ 15).Interventions. Patients received amiloride solution orally (10 mg of amiloride 1‐mg/ml solution) and by inhalation [4.5 ml amiloride of 1‐mg/ml solu

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Zou, Jiayun, Huazhen Wang, Yongshan Nan, and Xianglan Jin. "Stubborn hypoxemia after mild to moderate sedation and analgesia: A case report." Medicine 103, no. 7 (2024): e37059. http://dx.doi.org/10.1097/md.0000000000037059.

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Introduction: Atelectasis typically denotes the partial or complete collapse of lung segments, lobes, or lobules in individuals, leading to a compromised respiratory function. The prevalence of perioperative atelectasis may be significantly underestimated, particularly among patients subjected to general anesthesia. Patient concerns: This article conducts a retrospective analysis of a case involving refractory hypoxemia in a patient with a liver tumor who was admitted to Yanbian University Affiliated Hospital (Yanbian Hospital) after undergoing mild-to-moderate sedation and analgesia outside t

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Taher, Muhammad, Siti Syazwani Shaari, and Deny Susanti. "Potential Nanospray Inhalation of Remdesivir and Hydroxychloroquine using Poly (lactic-co-glycolic) Acid as Fast Delivery for Covid-19 Treatment." Journal of Pharmacy 1, no. 1 (2021): 34–44. http://dx.doi.org/10.31436/jop.v1i1.50.

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Introduction: The oral medication of remdesivir and hydroxychloroquine face several limitations in covid-19 therapy. Despite having the first-pass metabolism, it also has a limitation in the patient who has hospitalised with a severe covid-19 infection. It is especially for a drug that is targeting the angiotensin-converting enzyme II (ACE2) receptor where the receptors are found abundantly in the lung, kidney, heart, and gastrointestinal tract. Therefore, an alternative delivery such as nanospray inhalation would provide a great benefit to those patients. Methods: Scientific sources from Scop

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Kazarina, L. N., and I. M. Chuvarkova. "Paresthesia of mucosae membranes of an oral cavity against the background of taking inhaled hormonal drugs." Bulletin of the Russian Military Medical Academy 20, no. 4 (2018): 101–5. http://dx.doi.org/10.17816/brmma12291.

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Bronchial asthma draws the attention of increasing number of doctors worldwide. The prevalence of this disease is from 4 to 10%. Nowadays basic medicines for treatment and control of bronchial asthma are inhalation hormonal drugs which are taken daily and for a long time, often the whole life of a patient. According to numerous literary data, this drug group owing to a way of their introduction causes a series of complications in an oral cavity. The most frequent of them are the oropharyngeal candidiasis, a dysphonia and paresthesia of a mucosa of a mouth. Above-mentioned complications are dir

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Proch, Jędrzej. "UKŁADY ŁĄCZONE OPARTE NA DETEKCJI PRZY UŻYCIU OPTYCZNEJ SPEKTROMETRII EMISYJNEJ W OZNACZANIU FORM METALI I METALOIDÓW." Wiadomości Chemiczne 79, no. 1 (2023): 61–79. https://doi.org/10.53584/wiadchem.2025.1.4.

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Hydride generation (HG) has become a widely used technique for efficient analyte introduction in optical emission spectrometry, although only few hyphenated systems using this technique have been developed. It was decided to fill this gap using a modified spray chamber that allows with conventional nebulizer and/or as hydride generator, i.e. the Multi-mode Sample Introduction System (MSIS). The MSIS unit was used as an interface between high-performance liquid chromatography (HPLC) and inductively coupled plasma optical emission spectrometry (ICP OES) or microwave induced plasma optical emissi

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Shvechkova, M. V., I. I. Kukarskaya, R. N. Marchenko, et al. "Experience of using surfactant therapy for pneumonia associated with COVID-19 of obstetric patients." Remedium Journal about the Russian market of medicines and medical equipment, no. 11-12 (2020): 42–47. http://dx.doi.org/10.21518/1561-5936-2020-11-12-42-47.

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Introduction. Pregnant women may be at increased risk for severe COVID-19 illness. Pregnant women are more likely to be hospitalized at ICU, needed the mechanical ventilation compared to nonpregnant women. The pregnant women are currently excluded from the most of the clinical trials of COVID-19 drug therapy. This limits the formulation of appropriate recommendations for the treatment of pregnant women with SARS-CoV-2 infection. Building on the experience of the effective use of surfactant therapy for influenza A/H1N1 treatment of pregnant women with COVID-19, the domestic/local drug Surfactan

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Santos, Maria Da Conceição Luna dos, Cássia Cristina Cabral Marques, Gizelly Da Costa Ferreira, Elisângela Ferreira de Oliveira Gonçalves, Décio Peixoto Medeiros, and José Ângelo Rizzo. "Homemade spacers: a simple, efficient and cheap way of helping the patients to use their metered dose inhaler correctly." Revista de Enfermagem UFPE on line 5, no. 2 (2011): 489. http://dx.doi.org/10.5205/reuol.1718-11976-1-le.05spe201123.

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ABSTRACTObjective: to review the inhalation therapy basic concepts and their straight relation with asthma treatment and the metered dose inhalers attached to homemade spacers as an alternative of decreasing mistakes made at the inhalation practice. Methodology: a literature review has been made integrating the national and international publication searched at Scielo, PubMed/Medline, Cochrane. Randomized clinical trials have been selected, metanalysis and systematic reviews by using describers asthma, metered dose inhalers and spacers. Results: the metered dose inhalers show advantages like c

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Shvechkova, M. V., I. I. Kukarskaya, A. E. Bautin, et al. "Surfactant therapy for pneumonia COVID-19 of obstetric patients." Meditsinskiy sovet = Medical Council, no. 4 (April 6, 2022): 66–73. http://dx.doi.org/10.21518/2079-701x-2022-16-4-66-73.

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Introduction. Pregnant women may be at increased risk for severe COVID-19 illness. Pregnant women are more likely to be hospitalized at ICU, needed the mechanical ventilation compared to nonpregnant women of childbearing age. Building on the experience of the effective use of the exogenous surfactant for influenza A/H1N1 treatment of pregnant women with COVID-19, the surfactant therapy has also been included in the treatment.The objective. To evaluate the effectiveness of surfactant therapy in the integrated treatment of severe COVID-19 pneumonia of pregnant women and postpartum women.Material

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Almutairi, Aisha, Abdullah M. Alolayan, Afrah H. Alazmi, Raghad Y. Alghurayr, Rehab A. Alrashidi, and Jolan S. Alsaud. "Incorrect use for Inhalation Techniques of Inhaled Medication among Children with Asthma in Qassim Region: Prevalence and its Risk." Pakistan Journal of Medical and Health Sciences 16, no. 2 (2022): 896–902. http://dx.doi.org/10.53350/pjmhs22162896.

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Introduction: Asthma is one of the world's most common chronic respiratory disorders, and inhalers are frequently recommended to help manage allergy symptoms, improve quality of life, and reduce the risk of exacerbations or flare-ups. In Saudi Arabia, the prevalence of asthma is relatively high. Inhaler misuse can result in a variety of problems. This study aims to measure the prevalence of correct use of inhalation techniques of inhaled medication among children with asthma and investigate whether improper inhaler use can lead to uncontrolled bronchial asthma and its problems. Material and Me

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almutairi, Aisha, Abdullah M. Alolyan, Afrah H. Alazmi, Raghad Y. Alghurayr, Rehab A. Alrashidi, and Jolan S. Alsaud. "Incorrect use for Inhalation Techniques of Inhaled Medication among Children with Asthma in Qassim Region: Prevalence and its Risk." Pakistan Journal of Medical and Health Sciences 16, no. 1 (2022): 1329–35. http://dx.doi.org/10.53350/pjmhs221611329.

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Introduction: Asthma is one of the world's most common chronic respiratory disorders, and inhalers are frequently recommended to help manage allergy symptoms, improve quality of life, and reduce the risk of exacerbations or flare-ups. In Saudi Arabia, the prevalence of asthma is relatively high. Inhaler misuse can result in a variety of problems. This study aims to measure the prevalence of correct use of inhalation techniques of inhaled medication among children with asthma and investigate whether improper inhaler use can lead to uncontrolled bronchial asthma and its problems. Material and Me

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Sanjaya, Wisnu, Dhani Redhono Harioputro, and Yulyani Werdiningsih. "Lung Damage Prevention of Ethanolic Extract of Propolis and Synbiotics in Inhalation Anthrax Model." Sign of clinical medicine 1, no. 1 (2023): 1. http://dx.doi.org/10.20961/tscm.v1i1.55203.

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<p class="AbstractNormal"><strong>Introduction:</strong><strong> </strong>Inflammatory response and oxidative stress can be found in inhalation anthrax characterized by the increased level of serum Tumor Necrosis Factor Alpha (TNF-α) and Malondialdehyde (MDA). Ethanolic Extract of Propolis (EEP) and synbiotics were known to have anti-inflammatory and antioxidant properties. This study aimed to determine the effects of EEP and synbiotics on the level of TNF-α and MDA in inhalation anthrax model.</p><p class="AbstractNormal"><strong>Methods:</st

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Kelly, Edward J., John W. Keyloun, Bonnie C. Carney, Lauren T. Moffatt, and Jeffrey W. Shupp. "45 Endothelial Damage Occurs Early After Inhalation Injury as Measured by Increased syndecan-1 Levels." Journal of Burn Care & Research 43, Supplement_1 (2022): S31. http://dx.doi.org/10.1093/jbcr/irac012.048.

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Abstract Introduction Inhalation injury is a significant cause of morbidity and mortality in the burn patient population. However, the pathogenesis of inhalation injury and its potential involvement in burn shock is not well understood. Pre-clinical studies have shown endothelial injury, as measured by syndecan-1 levels, to be involved in the increased vascular permeability seen in shock states. Furthermore, the lung has been identified as a site of significant syndecan-1 shedding. Here we aim to characterize the contribution of endotheliopathy caused by inhalation alone in a swine model. Meth

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Carmo, Beatriz Bispo do, Giovanna Bernardi Gonçalves Oliveira, Juliana Emanuele Menezes, et al. "The use of Sodium Bicarbonate Inhaled Solution in Moderate/Severe Cases of Covid-19 in the City of Aquidauana, Mato Grosso do Sul, Brazil." International Journal of Advanced Engineering Research and Science 10, no. 3 (2023): 007–19. http://dx.doi.org/10.22161/ijaers.103.2.

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On March 11, 2020, the World Health Organization declared the new Coronavirus a pandemic, due to the large number of cases and deaths worldwide. The upper inhalation routes are the gateway for any viral variant, with the installation of SAR-CoV-2 in the respiratory epithelium, which, belonging to the Coronovidae family, has an acidic pH. Alkalization is a way to destabilize the pathophysiology of COVID-19. In this way, the introduction of saline solutions into the upper respiratory system would be a way of interfering with the symptomatology and behavior of the virus. Objective: To evaluate th

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Ohbayashi, Hiroyuki, Takamitsu Asano, Sahori Kudo, and Mitsue Ariga. "Comparison of User Satisfaction and Preference with Inhalant Devices Between a Pressurized Metered-Dose Inhaler and Ellipta in Stable Asthma Patients: A Randomized, Crossover Study." Pulmonary Therapy 7, no. 1 (2021): 171–87. http://dx.doi.org/10.1007/s41030-021-00149-6.

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Abstract Introduction Inhalation therapy involves two types of adherence: adherence to the drug and adherence to the procedures for the inhalation device. User satisfaction and preference are key factors for maintaining good adherence of both types, and they should be evaluated based on three conditions being well maintained: asthma control level (ACL), adherence, and adequate device operability during usage duration. We compared user satisfaction and preference between a pressurized metered-dose inhaler (pMDI) and a dry powder inhaler (Ellipta), while maintaining the three conditions during u

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Petrova, Guergana, Tanya Strateva, Dimitrinka Miteva, Snezhina Lazova, and Penka Perenovska. "Antimicrobial susceptibility of Pseudomonas aeruginosa before and after initiation of inhaled tobramycin in Bulgaria." Journal of Infection in Developing Countries 10, no. 11 (2016): 1265–67. http://dx.doi.org/10.3855/jidc.7658.

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Introduction: In aim to achieve better infection control and possible eradication of the pathogens involved in chronic infections of patients with cystic fibrosis (CF) scientists have developed a new way to administer antimicrobials – inhalation. The first and so far the only available inhalable antimicrobial in Bulgaria is inhaled tobramycin (TOBI), introduced in 2009.We aimed to evaluate the antimicrobial susceptibility of Pseudomonas aeruginosa isolates from cystic fibrosis (CF) patients before and after initiation of TOBI in the regular treatment regimen. Methodology: We have determined th

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Solís-Lemus, José A., Edward Costar, Denis Doorly, et al. "A simulated single ventilator/dual patient ventilation strategy for acute respiratory distress syndrome during the COVID-19 pandemic." Royal Society Open Science 7, no. 8 (2020): 200585. http://dx.doi.org/10.1098/rsos.200585.

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The potential for acute shortages of ventilators at the peak of the COVID-19 pandemic has raised the possibility of needing to support two patients from a single ventilator. To provide a system for understanding and prototyping designs, we have developed a mathematical model of two patients supported by a mechanical ventilator. We propose a standard set-up where we simulate the introduction of T-splitters to supply air to two patients and a modified set-up where we introduce a variable resistance in each inhalation pathway and one-way valves in each exhalation pathway. Using the standard set-u

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Muhammad Anis Taslim and Luqman Hakim. "The Effectiveness of Aromatherapy on Sleep Quality, Anxiety, and Fatigue in Patients Undergoing Hemodialysis : A Systematic Review." Nursing Care Journal 3, no. 2 (2025): 16–24. https://doi.org/10.63520/ncj.v3i2.666.

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Introduction: Aromatherapy is a complementary alternative medicine, its a natural way of treatment for patient undergoing hemodialysis. This study systematically reviews the literature to ensure the effectiveness of aromatherapy on sleep quality, anxiety and fatigue in patients undergoing hemodialysis. Methods: We used “aromatherapy” restricted our search to “sleep quality” and “anxiety” and “fatigue” and used “hemodialysis”, keywords and abstract connected by the Boolean operator “AND”. Search articles in the international database; EBSCO, Science Direct, Scopus, ProQuest, limited to the last

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Gazdić, Vera. "A brief history of anaesthesia." Scripta Medica 51, no. 3 (2020): 190–97. http://dx.doi.org/10.5937/scriptamed51-25992.

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According to the definition of the International Association for the Study of Pain (IASP), pain is defined as: "Unpleasant subjective feeling and emotional experience associated with current or potential tissue damage of a particular localisation", which, as such, poses a challenge for epidemiological research to determine its frequency and prevalence. We have all heard the motto that surgery has experienced its unprecedented development on the wings of anaesthesia. This is most certainly the case, since it is precisely the pain that prevents any invasive procedure on the human body, hence the

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Latha, R., and S. Sarveghna Lakshmi. "A study on immediate and training effect of Bhramari pranayama on heart rate variability in healthy adolescents." Biomedicine 42, no. 4 (2022): 784–88. http://dx.doi.org/10.51248/.v42i4.1501.

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Introduction and Aim: Bhramari pranayama (Humming bee breath) is the most common slow pranayama practice involving inhalation through both nostrils followed by exhalation which produces sound of humming bee. Practicing pranayama reduces the effects of stress on different systems by increasing the vagal tone. With the ongoing COVID-19 pandemic, there are heightened feelings of stress, anxiety and depression and pranayama can be an effective way to improve our mental and emotional well-being. This study has been chosen to assess the effect of Bhramari pranayama on autonomic functions and to comp

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Brito, Murilo de Oliveira, Meliza Arantes de Souza Bessa, Ralciane de Paula Menezes, et al. "Isolation of Cryptococcus species from the external environments of hospital and academic areas." Journal of Infection in Developing Countries 13, no. 06 (2019): 545–53. http://dx.doi.org/10.3855/jidc.10849.

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Introduction: Fungi of the genus Cryptococcus are cosmopolitan and may be agents of opportunistic mycoses in immunocompromised and sometimes immunocompetent individuals. Cryptococcus species are frequently isolated from trees and bird excreta in the environment and infection occurs by inhalation of propagules dispersed in the air. The aim was to investigate Cryptococcus species in bird excreta and tree hollows located in a university hospital area and in an academic area of a university campus. Methodology: A total of 40 samples of bird excreta and 41 samples of tree hollows were collect

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Romero, Martha, Marcela Varona, Milciades Ibáñez-Pinilla, and Leonardo Briceño. "Prevalence of pneumoconiosis and spirometric findings in underground mining workers in Cundinamarca, Colombia." Revista de la Facultad de Medicina 67, no. 4 (2019): 393–98. http://dx.doi.org/10.15446/revfacmed.v67n4.72201.

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Introduction: Coal worker’s pneumoconiosis is caused by the inhalation of coal dust and its accumulation in the lungs after several years of exposure.Objective: To determine the prevalence of pneumoconiosis in underground mining workers exposed to coal dust in Cundinamarca, Colombia, and its association with their spirometry results and respiratory symptoms.Materials and methods: Cross-sectional study conducted on 215 workers who were administered a questionnaire on respiratory symptoms. For each worker a chest radiograph was taken according to the criteria of the International Labor Organizat

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