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Articles de revues sur le sujet « Ion channels Molecular aspects »

Auteur : Grafiati

Publié le 4 juin 2021

Mis à jour le 28 janvier 2023

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1

IMOTO, KEIJI. "Molecular Aspects of Ion Permeation through Channels." Annals of the New York Academy of Sciences 707, no. 1 Molecular Bas (December 1993): 38–50. http://dx.doi.org/10.1111/j.1749-6632.1993.tb38040.x.

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Vacher, Helene, Durga P. Mohapatra, and James S. Trimmer. "Localization and Targeting of Voltage-Dependent Ion Channels in Mammalian Central Neurons." Physiological Reviews 88, no. 4 (October 2008): 1407–47. http://dx.doi.org/10.1152/physrev.00002.2008.

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The intrinsic electrical properties and the synaptic input-output relationships of neurons are governed by the action of voltage-dependent ion channels. The localization of specific populations of ion channels with distinct functional properties at discrete sites in neurons dramatically impacts excitability and synaptic transmission. Molecular cloning studies have revealed a large family of genes encoding voltage-dependent ion channel principal and auxiliary subunits, most of which are expressed in mammalian central neurons. Much recent effort has focused on determining which of these subunits

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Fahlke, Christoph. "Ion permeation and selectivity in ClC-type chloride channels." American Journal of Physiology-Renal Physiology 280, no. 5 (May 1, 2001): F748—F757. http://dx.doi.org/10.1152/ajprenal.2001.280.5.f748.

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Voltage-gated anion channels are present in almost every living cell and have many physiological functions. Recently, a novel gene family encoding voltage-gated chloride channels, the ClC family, was identified. The knowledge of primary amino acid sequences has allowed for the study of these anion channels in heterologous expression systems and made possible the combination of site-directed mutagenesis and high-resolution electrophysiological measurements as a means of gaining insights into the molecular basis of channel function. This review focuses on one particular aspect of chloride channe

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Tiffner, Adéla, Valentina Hopl, and Isabella Derler. "CRAC and SK Channels: Their Molecular Mechanisms Associated with Cancer Cell Development." Cancers 15, no. 1 (December 23, 2022): 101. http://dx.doi.org/10.3390/cancers15010101.

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Cancer represents a major health burden worldwide. Several molecular targets have been discovered alongside treatments with positive clinical outcomes. However, the reoccurrence of cancer due to therapy resistance remains the primary cause of mortality. Endeavors in pinpointing new markers as molecular targets in cancer therapy are highly desired. The significance of the co-regulation of Ca2+-permeating and Ca2+-regulated ion channels in cancer cell development, proliferation, and migration make them promising molecular targets in cancer therapy. In particular, the co-regulation of the Orai1 a

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Arcangeli, Annarosa. "Ion channels and transporters in cancer. 3. Ion channels in the tumor cell-microenvironment cross talk." American Journal of Physiology-Cell Physiology 301, no. 4 (October 2011): C762—C771. http://dx.doi.org/10.1152/ajpcell.00113.2011.

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The traditional view of cancer as a collection of proliferating cells must be reconsidered, and cancer must be viewed as a “tissue” constituted by both transformed cells and a heterogeneous microenvironment, that tumor cells construct and remodel during multistep tumorigenesis. The “tumor microenvironment” (TM) is formed by mesenchymal, endothelial, and immune cells immersed in a network of extracellular matrix (ECM) proteins and soluble factors. The TM strongly contributes to tumor progression, through long distance, cell-to-cell or cell-to-matrix signals, which influence different aspects of

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Hernández-Araiza, Ileana, Sara L. Morales-Lázaro, Jesús Aldair Canul-Sánchez, León D. Islas, and Tamara Rosenbaum. "Role of lysophosphatidic acid in ion channel function and disease." Journal of Neurophysiology 120, no. 3 (September 1, 2018): 1198–211. http://dx.doi.org/10.1152/jn.00226.2018.

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Lysophosphatidic acid (LPA) is a bioactive phospholipid that exhibits a wide array of functions that include regulation of protein synthesis and adequate development of organisms. LPA is present in the membranes of cells and in the serum of several mammals and has also been shown to participate importantly in pathophysiological conditions. For several decades it was known that LPA produces some of its effects in cells through its interaction with specific G protein-coupled receptors, which in turn are responsible for signaling pathways that regulate cellular function. Among the target proteins

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Kytikova, Oxana Yu, Tatyana P. Novgorodtseva, Yulia K. Denisenko, Denis E. Naumov, Tatyana A. Gvozdenko, and Juliy M. Perelman. "Thermosensory Transient Receptor Potential Ion Channels and Asthma." Biomedicines 9, no. 7 (July 14, 2021): 816. http://dx.doi.org/10.3390/biomedicines9070816.

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Asthma is a widespread chronic disease of the bronchopulmonary system with a heterogeneous course due to the complex etiopathogenesis. Natural-climatic and anthropogenic factors play an important role in the development and progression of this pathology. The reception of physical and chemical environmental stimuli and the regulation of body temperature are mediated by thermosensory channels, members of a subfamily of transient receptor potential (TRP) ion channels. It has been found that genes encoding vanilloid, ankyrin, and melastatin TRP channels are involved in the development of some asth

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Weissmann, Carina, Adriana A. Albanese, Natalia E. Contreras, María N. Gobetto, Libia C. Salinas Castellanos, and Osvaldo D. Uchitel. "Ion channels and pain in Fabry disease." Molecular Pain 17 (January 2021): 174480692110331. http://dx.doi.org/10.1177/17448069211033172.

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Fabry disease (FD) is a progressive, X-linked inherited disorder of glycosphingolipid metabolism due to deficient or absent lysosomal α-galactosidase A (α-Gal A) activity which results in progressive accumulation of globotriaosylceramide (Gb3) and related metabolites. One prominent feature of Fabry disease is neuropathic pain. Accumulation of Gb3 has been documented in dorsal root ganglia (DRG) as well as other neurons, and has lately been associated with the mechanism of pain though the pathophysiology is still unclear. Small fiber (SF) neuropathy in FD differs from other entities in several

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Turner, Kathryn L., and Harald Sontheimer. "Cl − and K + channels and their role in primary brain tumour biology." Philosophical Transactions of the Royal Society B: Biological Sciences 369, no. 1638 (March 19, 2014): 20130095. http://dx.doi.org/10.1098/rstb.2013.0095.

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Profound cell volume changes occur in primary brain tumours as they proliferate, invade surrounding tissue or undergo apoptosis. These volume changes are regulated by the flux of Cl − and K + ions and concomitant movement of water across the membrane, making ion channels pivotal to tumour biology. We discuss which specific Cl − and K + channels are involved in defined aspects of glioma biology and how these channels are regulated. Cl − is accumulated to unusually high concentrations in gliomas by the activity of the NKCC1 transporter and serves as an osmolyte and energetic driving force for vo

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Flaxer, Eli. "Comprehensive Controller for Super Sonic Molecular Beam Gas Chromatograph Mass Spectrometer." Separations 9, no. 12 (December 7, 2022): 417. http://dx.doi.org/10.3390/separations9120417.

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This paper presents a new, comprehensive digital circuit used for the control of a novel gas chromatograph mass spectrometer (GC-MS) interface that is based on supersonic molecular beam (SMB). The circuit includes a Texas Instruments 150 MHz digital signal controller (DSC), high voltage amplifiers for 8 independent channels and 4 independent channels of high resolution pulse width modulation (PWM). The circuit, along with a sophisticated embedded program and a custom made personal computer (PC) application, control all aspects of the interface: smart filament emission-current stabilization, st

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Keynes, R. D. "Current Topics in Membranes and Transport, Vol. 21: Ion Channels: Molecular and Physiological Aspects." Trends in Neurosciences 8 (January 1985): 226. http://dx.doi.org/10.1016/0166-2236(85)90089-x.

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Kyriacou, E. "Reconstitution of Single Potassium Channels from Bovine Gallbladder Epithelium." Journal of International Medical Research 26, no. 4 (August 1998): 188–99. http://dx.doi.org/10.1177/030006059802600403.

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The study of molecular transport across gall-bladder epithelium may contribute to our understanding of the pathophysiology of gall-bladder disease. The aim of this study was to reconstitute and characterize single potassium ion channels in bovine gall-bladder epithelial mucosa – both apical and basolateral aspects. Standard subcellular fractionation techniques were used to form either apical or basolateral closed-membrane vesicles from the mucosal epithelium of fresh gall bladders from healthy young adult cattle. Vesicular ion channels were incorporated into voltage-clamped planar lipid bilaye

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Moody, William J., and Martha M. Bosma. "Ion Channel Development, Spontaneous Activity, and Activity-Dependent Development in Nerve and Muscle Cells." Physiological Reviews 85, no. 3 (July 2005): 883–941. http://dx.doi.org/10.1152/physrev.00017.2004.

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At specific stages of development, nerve and muscle cells generate spontaneous electrical activity that is required for normal maturation of intrinsic excitability and synaptic connectivity. The patterns of this spontaneous activity are not simply immature versions of the mature activity, but rather are highly specialized to initiate and control many aspects of neuronal development. The configuration of voltage- and ligand-gated ion channels that are expressed early in development regulate the timing and waveform of this activity. They also regulate Ca2+ influx during spontaneous activity, whi

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López-Vera, Estuardo, Luis Martínez-Hernández, Manuel B. Aguilar, Elisa Carrillo, and Joanna Gajewiak. "Studies of Conorfamide-Sr3 on Human Voltage-Gated Kv1 Potassium Channel Subtypes." Marine Drugs 18, no. 8 (August 13, 2020): 425. http://dx.doi.org/10.3390/md18080425.

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Recently, Conorfamide-Sr3 (CNF-Sr3) was isolated from the venom of Conus spurius and was demonstrated to have an inhibitory concentration-dependent effect on the Shaker K+ channel. The voltage-gated potassium channels play critical functions on cellular signaling, from the regeneration of action potentials in neurons to the regulation of insulin secretion in pancreatic cells, among others. In mammals, there are at least 40 genes encoding voltage-gated K+ channels and the process of expression of some of them may include alternative splicing. Given the enormous variety of these channels and the

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Nagaeva, E. I., N. N. Potapieva, and D. B. Tikhonov. "The Effect of Hydrophobic Monoamines on Acid-Sensing Ion Channels ASIC1B." Acta Naturae 7, no. 2 (June 15, 2015): 95–101. http://dx.doi.org/10.32607/20758251-2015-7-2-95-101.

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Acid-sensing ion channels (ASICs) are widely distributed in both the central and peripheral nervous systems of vertebrates. The pharmacology of these receptors remains poorly investigated, while the search for new ASIC modulators is very important. Recently, we found that some monoamines, which are blockers of NMDA receptors, inhibit and/or potentiate acid-sensing ion channels, depending on the subunit composition of the channels. The effect of 9-aminoacridine, IEM-1921, IEM-2117, and memantine both on native receptors and on recombinant ASIC1a, ASIC2a, and ASIC3 homomers was studied. In the p

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Roux, Benoît, Toby Allen, Simon Bernèche, and Wonpil Im. "Theoretical and computational models of biological ion channels." Quarterly Reviews of Biophysics 37, no. 1 (February 2004): 15–103. http://dx.doi.org/10.1017/s0033583504003968.

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1. Introduction 172. Dynamics of many-body systems 192.1 Effective dynamics of reduced systems 212.2 The constraint of thermodynamic equilibrium 242.3 Mean-field theories 253. Solvation free energy and electrostatics 273.1 Microscopic view of the Born model 273.2 Ion–Ion interactions in bulk solution 293.3 Continuum electrostatics and the PB equation 293.4 Limitations of continuum dielectric models 323.5 The dielectric barrier 333.6 The transmembrane potential and the PB-V equation 354. Statistical mechanical equilibrium theory 404.1 Multi-ion PMF 404.2 Equilibrium probabilities of occupancy 4

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Walker, R. J., and L. Holden-Dye. "Evolutionary aspects of transmitter molecules, their receptors and channels." Parasitology 102, S1 (January 1991): S7—S29. http://dx.doi.org/10.1017/s0031182000073261.

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Classical transmitters are present in all phyla that have been studied; however, our detailed understanding of the process of neurotransmission in these phyla is patchy and has centred on those neurotransmitter receptor mechanisms which are amenable to study with the tools available at the time, for example, high-affinity ligands, tissues with high density of receptor protein, suitable electrophysio-logical recording systems. Studies also clearly show that many neurones exhibit co-localization of classical transmitters and neuropeptides. However, the physiological implications of this co-local

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Pla-Casillanis, Adrià, Laura Ferigle, Marta Alonso-Gardón, Efren Xicoy-Espaulella, Ekaitz Errasti-Murugarren, Daniela Marazziti, and Raúl Estévez. "GPR37 Receptors and Megalencephalic Leukoencephalopathy with Subcortical Cysts." International Journal of Molecular Sciences 23, no. 10 (May 16, 2022): 5528. http://dx.doi.org/10.3390/ijms23105528.

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Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is a rare type of vacuolating leukodystrophy (white matter disorder), which is mainly caused by defects in MLC1 or glial cell adhesion molecule (GlialCAM) proteins. In addition, autoantibodies to GlialCAM are involved in the pathology of multiple sclerosis. MLC1 and GLIALCAM genes encode for membrane proteins of unknown function, which has been linked to the regulation of different ion channels and transporters, such as the chloride channel VRAC (volume regulated anion channel), ClC-2 (chloride channel 2), and connexin 43 or the

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Cassinelli, Silvia, Carla Viñola-Renart, Anna Benavente-Garcia, María Navarro-Pérez, Jesusa Capera, and Antonio Felipe. "Palmitoylation of Voltage-Gated Ion Channels." International Journal of Molecular Sciences 23, no. 16 (August 19, 2022): 9357. http://dx.doi.org/10.3390/ijms23169357.

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Protein lipidation is one of the most common forms of posttranslational modification. This alteration couples different lipids, such as fatty acids, phospho- and glycolipids and sterols, to cellular proteins. Lipidation regulates different aspects of the protein’s physiology, including structure, stability and affinity for cellular membranes and protein–protein interactions. In this scenario, palmitoylation is the addition of long saturated fatty acid chains to amino acid residues of the proteins. The enzymes responsible for this modification are acyltransferases and thioesterases, which contr

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Sahlender, Daniela A., Iaroslav Savtchouk, and Andrea Volterra. "What do we know about gliotransmitter release from astrocytes?" Philosophical Transactions of the Royal Society B: Biological Sciences 369, no. 1654 (October 19, 2014): 20130592. http://dx.doi.org/10.1098/rstb.2013.0592.

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Astrocytes participate in information processing by actively modulating synaptic properties via gliotransmitter release. Various mechanisms of astrocytic release have been reported, including release from storage organelles via exocytosis and release from the cytosol via plasma membrane ion channels and pumps. It is still not fully clear which mechanisms operate under which conditions, but some of them, being Ca 2+ -regulated, may be physiologically relevant. The properties of Ca 2+ -dependent transmitter release via exocytosis or via ion channels are different and expected to produce differen

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Pullman, A. "Molecular aspects of channel formation and ion transport through membranes." Pure and Applied Chemistry 60, no. 2 (January 1, 1988): 259–64. http://dx.doi.org/10.1351/pac198860020259.

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Schneider, Nicole, Sönke Cordeiro, Jan-Philipp Machtens, Simona Braams, Thomas Rauen, and Christoph Fahlke. "Functional Properties of the Retinal Glutamate Transporters GLT-1c and EAAT5." Journal of Biological Chemistry 289, no. 3 (December 4, 2013): 1815–24. http://dx.doi.org/10.1074/jbc.m113.517177.

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In the mammalian retina, glutamate uptake is mediated by members of a family of glutamate transporters known as “excitatory amino acid transporters (EAATs).” Here we cloned and functionally characterized two retinal EAATs from mouse, the GLT-1/EAAT2 splice variant GLT-1c, and EAAT5. EAATs are glutamate transporters and anion-selective ion channels, and we used heterologous expression in mammalian cells, patch-clamp recordings and noise analysis to study and compare glutamate transport and anion channel properties of both EAAT isoforms. We found GLT-1c to be an effective glutamate transporter w

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Chauhan, Anurag Singh, Ganesh Chandra Sahoo, Manas Ranjan Dikhit, and Pradeep Das. "Acid-Sensing Ion Channels Structural Aspects, Pathophysiological Importance and Experimental Mutational Data Available Across Various Species to Target Human ASIC1." Current Drug Targets 20, no. 1 (November 27, 2018): 111–21. http://dx.doi.org/10.2174/1389450119666180820103316.

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The H+-gated (proton) currents are widely present in brain sensory neuronal system and various studies identified the structural units and deciphered the physiological and pathological function of ion channels. The normal neuron requires an optimal pH to carry out its functions. In acidosis, the ASICs (Acid-sensing Ion Channels) are activated in both the CNS (central nervous system) and PNS (peripheral nervous system). ASICs are related to degenerin channels (DEGs), epithelial sodium cation channels (ENaCs), and FMRF-amide (Phe-Met-Arg-Phe-NH2)-gated channels (FaNaC). Its activation leads phys

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Rubaiy, Hussein Nori. "A Short Guide to Electrophysiology and Ion Channels." Journal of Pharmacy & Pharmaceutical Sciences 20 (March 15, 2017): 48. http://dx.doi.org/10.18433/j32p6r.

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The birth and discovery of electrophysiological science took place in the 18th century laying the path for our understanding of nerve membrane ionic currents. The pore-forming proteins, ion channels, are involved and play critical roles in very important physiological and pathological processes, such as neuronal signaling and cardiac excitability, therefore, they serve as therapeutic drug targets. The study of physiological, pharmacological and biophysical properties of ion channels can be done by patch clamp, a gold standard and powerful electrophysiological technique. The current review, i

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Barros, Francisco, Luis Pardo, Pedro Domínguez, Luisa Sierra, and Pilar de la Peña. "New Structures and Gating of Voltage-Dependent Potassium (Kv) Channels and Their Relatives: A Multi-Domain and Dynamic Question." International Journal of Molecular Sciences 20, no. 2 (January 10, 2019): 248. http://dx.doi.org/10.3390/ijms20020248.

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Voltage-dependent potassium channels (Kv channels) are crucial regulators of cell excitability that participate in a range of physiological and pathophysiological processes. These channels are molecular machines that display a mechanism (known as gating) for opening and closing a gate located in a pore domain (PD). In Kv channels, this mechanism is triggered and controlled by changes in the magnitude of the transmembrane voltage sensed by a voltage-sensing domain (VSD). In this review, we consider several aspects of the VSD–PD coupling in Kv channels, and in some relatives, that share a common

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Agnati, Luigi F., Manuela Marcoli, Guido Maura, Kjell Fuxe, and Diego Guidolin. "The multi-facet aspects of cell sentience and their relevance for the integrative brain actions: role of membrane protein energy landscape." Reviews in the Neurosciences 27, no. 4 (June 1, 2016): 347–63. http://dx.doi.org/10.1515/revneuro-2015-0049.

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AbstractSeveral ion channels can be randomly and spontaneously in an open state, allowing the exchange of ion fluxes between extracellular and intracellular environments. We propose that the random changes in the state of ion channels could be also due to proteins exploring their energy landscapes. Indeed, proteins can modify their steric conformation under the effects of the physicochemical parameters of the environments with which they are in contact, namely, the extracellular, intramembrane and intracellular environments. In particular, it is proposed that the random walk of proteins in the

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Fink, Martin, and Denis Noble. "Markov models for ion channels: versatility versus identifiability and speed." Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 367, no. 1896 (June 13, 2009): 2161–79. http://dx.doi.org/10.1098/rsta.2008.0301.

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Markov models (MMs) represent a generalization of Hodgkin–Huxley models. They provide a versatile structure for modelling single channel data, gating currents, state-dependent drug interaction data, exchanger and pump dynamics, etc. This paper uses examples from cardiac electrophysiology to discuss aspects related to parameter estimation. (i) Parameter unidentifiability (found in 9 out of 13 of the considered models) results in an inability to determine the correct layout of a model, contradicting the idea that model structure and parameters provide insights into underlying molecular processes

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Gasimova, Yegana Aydin. "Modern neurochemical and molecular genetic aspects of the pathogenesis of neonatal seizures." Modern pediatrics. Ukraine, no. 6(110) (October 30, 2020): 32–35. http://dx.doi.org/10.15574/sp.2020.110.32.

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The article is devoted to the modern aspects of the pathogenesis of neonatal seizures (NS). The main mechanisms of the development of perinatal brain injuries, which are fundamental in the genesis of NS, are considered, the prospects for research devoted to the study of the possibilities of molecular genetic prediction of the individual risk of ischemia and the development of NS are outlined. The mechanisms of ischemic brain damage during the neonatal period and the role of glutamate, the main excitatory neurotransmitter acting on NMDA receptors that regulate the electrical activity of neurons

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PERRAUD, A. "Novel aspects of signaling and ion-homeostasis regulation in immunocytesThe TRPM ion channels and their potential role in modulating the immune response." Molecular Immunology 41, no. 6-7 (July 2004): 657–73. http://dx.doi.org/10.1016/j.molimm.2004.04.013.

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Golukhova, E. Z., O. I. Gromova, R. A. Shomahov, N. I. Bulaeva, and L. A. Bockeria. "Monogenec Arrhythmic Syndromes: From Molecular and Genetic Aspects to Bedside." Acta Naturae 8, no. 2 (June 15, 2016): 62–74. http://dx.doi.org/10.32607/20758251-2016-8-2-62-74.

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The abrupt cessation of effective cardiac function that is generally due to heart rhythm disorders can cause sudden and unexpected death at any age and is referred to as a syndrome called sudden cardiac death (SCD). Annually, about 400,000 cases of SCD occur in the United States alone. Less than 5% of the resuscitation techniques are effective. The prevalence of SCD in a population rises with age according to the prevalence of coronary artery disease, which is the most common cause of sudden cardiac arrest. However, there is a peak in SCD incidence for the age below 5 years, which is equal to

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Berridge, M. J. "Elementary and global aspects of calcium signalling." Journal of Experimental Biology 200, no. 2 (January 1, 1997): 315–19. http://dx.doi.org/10.1242/jeb.200.2.315.

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Calcium is a ubiquitous second messenger used to regulate a wide range of cellular processes. This role in signalling has to be conducted against the rigid homeostatic mechanisms that ensure that the resting level of Ca2+ is kept low (i.e. between 20 and 100 nmol l-1) in order to avoid the cytotoxic effects of a prolonged elevation of [Ca2+]. Cells have evolved a sophisticated signalling system based on the generation of brief pulses of Ca2+ which enables this ion to be used as a messenger, thus avoiding its toxic effects. Such Ca2+ spikes usually result from the coordinated release of Ca2+ fr

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Fraser, Scott P., Iley Ozerlat-Gunduz, William J. Brackenbury, Elizabeth M. Fitzgerald, Thomas M. Campbell, R. Charles Coombes, and Mustafa B. A. Djamgoz. "Regulation of voltage-gated sodium channel expression in cancer: hormones, growth factors and auto-regulation." Philosophical Transactions of the Royal Society B: Biological Sciences 369, no. 1638 (March 19, 2014): 20130105. http://dx.doi.org/10.1098/rstb.2013.0105.

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Although ion channels are increasingly being discovered in cancer cells in vitro and in vivo , and shown to contribute to different aspects and stages of the cancer process, much less is known about the mechanisms controlling their expression. Here, we focus on voltage-gated Na + channels (VGSCs) which are upregulated in many types of carcinomas where their activity potentiates cell behaviours integral to the metastatic cascade. Regulation of VGSCs occurs at a hierarchy of levels from transcription to post-translation. Importantly, mainstream cancer mechanisms, especially hormones and growth f

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Summhammer, Johann, Georg Sulyok, Gustav Bernroider, and Massimo Cocchi. "The Optimized Conformation Dynamics of the KcsA Filter as a Probe for Lateral Membrane Effects; A First Principle Based Femto-Sec Resolution MD Study." Membranes 12, no. 12 (November 24, 2022): 1183. http://dx.doi.org/10.3390/membranes12121183.

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We provide a high resolution, all-atom, femto-second molecular dynamics (MD) simulation of the passage of K+ ions and H2O molecules through the selectivity filter of the KcsA potassium ion channel, based on first principle physical methods. Our results show that a change in the length of the selectivity filter of as little as 3%, regardless of whether the filter is made longer or shorter, will reduce the K+ ion current by around 50%. In addition, further squeezing or stretching by about 9% can effectively stop the current. Our results demonstrate optimized conformational dynamics that associat

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Deutsch, Matthias, Carina Stegmayr, Sabine Balfanz, and Arnd Baumann. "Loss of HCN2 in Dorsal Hippocampus of Young Adult Mice Induces Specific Apoptosis of the CA1 Pyramidal Neuron Layer." International Journal of Molecular Sciences 22, no. 13 (June 22, 2021): 6699. http://dx.doi.org/10.3390/ijms22136699.

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Neurons inevitably rely on a proper repertoire and distribution of membrane-bound ion-conducting channels. Among these proteins, the family of hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels possesses unique properties giving rise to the corresponding Ih-current that contributes to various aspects of neural signaling. In mammals, four genes (hcn1-4) encode subunits of HCN channels. These subunits can assemble as hetero- or homotetrameric ion-conducting channels. In order to elaborate on the specific role of the HCN2 subunit in shaping electrical properties of neurons, we

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Mantegazza, Massimo, Sandrine Cestèle, and William A. Catterall. "Sodium channelopathies of skeletal muscle and brain." Physiological Reviews 101, no. 4 (October 1, 2021): 1633–89. http://dx.doi.org/10.1152/physrev.00025.2020.

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Voltage-gated sodium channels initiate action potentials in nerve, skeletal muscle, and other electrically excitable cells. Mutations in them cause a wide range of diseases. These channelopathy mutations affect every aspect of sodium channel function, including voltage sensing, voltage-dependent activation, ion conductance, fast and slow inactivation, and both biosynthesis and assembly. Mutations that cause different forms of periodic paralysis in skeletal muscle were discovered first and have provided a template for understanding structure, function, and pathophysiology at the molecular level

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Donato, Luigi, Concetta Scimone, Simona Alibrandi, Ebtesam Mohamed Abdalla, Karim Mahmoud Nabil, Rosalia D’Angelo, and Antonina Sidoti. "New Omics—Derived Perspectives on Retinal Dystrophies: Could Ion Channels-Encoding or Related Genes Act as Modifier of Pathological Phenotype?" International Journal of Molecular Sciences 22, no. 1 (December 23, 2020): 70. http://dx.doi.org/10.3390/ijms22010070.

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Ion channels are membrane-spanning integral proteins expressed in multiple organs, including the eye. Here, ion channels play a role in several physiological processes, like signal transmission and visual processing. A wide range of mutations have been reported in the corresponding genes and their interacting subunit coding genes, which contribute significantly to a wide spectrum of ocular diseases collectively called channelopathies, a subgroup of inherited retinal dystrophies. Such mutations result in either a loss or gain-of channel functions affecting the structure, assembly, trafficking a

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Cagomoc, Charisse Marie D., Michiro Isobe, Eric A. Hudson, and Satoshi Hamaguchi. "Molecular dynamics simulation of oxide-nitride bilayer etching with energetic fluorocarbon ions." Journal of Vacuum Science & Technology A 40, no. 6 (December 2022): 063006. http://dx.doi.org/10.1116/6.0002182.

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In 3D NAND devices, the number of stacked layers dictates the storage capacity. In the fabrication of such devices, hole channels with a high-aspect ratio (HAR) are etched through these layers. The higher the aspect ratio becomes, the more difficulties the HAR etching faces. In this study, molecular dynamics simulation was performed to examine the etching of silicon dioxide (SiO2), silicon nitride (SiN), and oxide-nitride (ON) stacked layers by energetic fluorocarbon ions. Good agreement of etching yields obtained from the simulations and ion beam experiments was observed for the etching of Si

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HAMM-ALVAREZ, SARAH F., and MICHAEL P. SHEETZ. "Microtubule-Dependent Vesicle Transport: Modulation of Channel and Transporter Activity in Liver and Kidney." Physiological Reviews 78, no. 4 (October 1, 1998): 1109–29. http://dx.doi.org/10.1152/physrev.1998.78.4.1109.

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Hamm-Alvarez, Sarah F., and Michael P. Sheetz. Microtubule-Dependent Vesicle Transport: Modulation of Channel and Transporter Activity in Liver and Kidney. Physiol. Rev. 78: 1109–1129, 1998. — Microtubule-based vesicle transport driven by kinesin and cytoplasmic dynein motor proteins facilitates several membrane-trafficking steps including elements of endocytosis and exocytosis in many different cell types. Most early studies on the role of microtubule-dependent vesicle transport in membrane trafficking focused either on neurons or on simple cell lines. More recently, other work has considered

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Pałasz, A., and P. Czekaj. "Toxicological and cytophysiological aspects of lanthanides action." Acta Biochimica Polonica 47, no. 4 (December 31, 2000): 1107–14. http://dx.doi.org/10.18388/abp.2000_3963.

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Lanthanides, also called rare-earth elements, are an interesting group of 15 chemically active, mainly trivalent, f-electronic, silvery-white metals. In fact, lanthanides are not as rare as the name implies, except for promethium, a radioactive artificial element not found in nature. The mean concentrations of lanthanides in the earth's crust are comparable to those of life-important elements like iodine, cobalt and selenium. Many lanthanide compounds show particular magnetic, catalytic and optic properties, and that is why their technical applications are so extensive. Numerous industrial sou

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Salmin, V. V., A. V. Morgun, R. Ya Olovyannikova, V. A. Kutyakov, E. V. Lychkovskaya, E. B. Brusina, and A. B. Salmina. "Atmospheric reactive oxygen species and some aspects of the antiviral protection of the respiratory epithelium." Biomeditsinskaya Khimiya 67, no. 5 (2021): 383–93. http://dx.doi.org/10.18097/pbmc20216705383.

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The review focuses on molecular and biochemical mechanisms of nonspecific protection of respiratory epithelium. The authors provide a comprehensive analysis of up-to-date data on the activity of the lactoperoxidase system expressed on the surface of the respiratory epithelium which provides the generation of hypothiocyanate and hypoiodite in the presence of locally produced or inhaled hydrogen peroxide. Molecular mechanisms of production of active compounds with antiviral and antibacterial effects, expression profiles of enzymes, transporters and ion channels involved in the generation of hypo

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Chioccioli Altadonna, Ginevra, Alberto Montalbano, Jessica Iorio, Andrea Becchetti, Annarosa Arcangeli та Claudia Duranti. "The Interaction between hERG1 and β1 Integrins Modulates hERG1 Current in Different Pathological Cell Models". Membranes 12, № 11 (18 листопада 2022): 1162. http://dx.doi.org/10.3390/membranes12111162.

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Ion channels are implicated in various diseases, including cancer, in which they modulate different aspects of cancer progression. In particular, potassium channels are often aberrantly expressed in cancers, a major example being provided by hERG1. The latter is generally complexed with β1 integrin in tumour cells, and such a molecular complex represents a new druggable hub. The present study focuses on the characterization of the functional consequences of the interaction between hERG1 and β1 integrins on different substrates over time. To this purpose, we studied the interplay alteration on

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Fiorio Pla, Alessandra, and Dimitra Gkika. "Ca2+ Channel Toolkit in Neuroendocrine Tumors." Neuroendocrinology 110, no. 1-2 (June 10, 2019): 147–54. http://dx.doi.org/10.1159/000501397.

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Neuroendocrine tumors (NET) constitute a heterogeneous group of malignancies with various clinical presentations and growth rates but a common origin in neuroendocrine cells located all over the body. NET are a relatively low-frequency disease mostly represented by gastroenteropancreatic (GEP) and bronchopulmonary tumors (pNET); on the other hand, an increasing frequency and prevalence have been associated with NET. Despite great efforts in recent years, the management of NET is still a critical unmet need due to the lack of knowledge of the biology of the disease, the lack of adequate biomark

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Szuts, Viktoria, Dalma Ménesi, Zoltán Varga-Orvos, Ágnes Zvara, Nazanin Houshmand, Miklós Bitay, Gábor Bogáts, et al. "Altered expression of genes for Kir ion channels in dilated cardiomyopathy." Canadian Journal of Physiology and Pharmacology 91, no. 8 (August 2013): 648–56. http://dx.doi.org/10.1139/cjpp-2012-0413.

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Dilated cardiomyopathy (DCM) is a multifactorial disease characterized by left ventricular dilation that is associated with systolic dysfunction and increased action potential duration. The Kir2.x K+ channels (encoded by KCNJ genes) regulate the inward rectifier current (IK1) contributing to the final repolarization in cardiac muscle. Here, we describe the transitions in the gene expression profiles of 4 KCNJ genes from healthy or dilated cardiomyopathic human hearts. In the healthy adult ventricles, KCNJ2, KCNJ12, and KCNJ4 (Kir2.1–2.3, respectively) genes were expressed at high levels, while

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Roy, Sisir, and Rodolfo Llinás. "Relevance of quantum mechanics on some aspects of ion channel function." Comptes Rendus Biologies 332, no. 6 (June 2009): 517–22. http://dx.doi.org/10.1016/j.crvi.2008.11.009.

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Nishida, Hirofumi, Toshiaki Sato, Takehiko Ogura, and Haruaki Nakaya. "New Aspects for the Treatment of Cardiac Diseases Based on the Diversity of Functional Controls on Cardiac Muscles: Mitochondrial Ion Channels and Cardioprotection." Journal of Pharmacological Sciences 109, no. 3 (2009): 341–47. http://dx.doi.org/10.1254/jphs.08r24fm.

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Fedosov, A. E., S. A. Moshkovskii, K. G. Kuznetsova, and B. M. Olivera. "Conotoxins: from the biodiversity of gastropods to new drugs." Biomeditsinskaya Khimiya 59, no. 3 (2013): 267–94. http://dx.doi.org/10.18097/pbmc20135903267.

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A review describes general trends in research of conotoxins that are peptide toxins isolated from sea gastropods of the Conus genus, since the toxins were discovered in 1970 . There are disclosed a conotoxin classification, their structure diversity and different ways of action to their molecular targets, mainly, ion channels. In the applied aspect of conotoxin research, drug discovery and development is discussed, the drugs being based on conotoxin structure. A first exemplary drug is a ziconotide, which is an analgesic of new generation.

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Jegorov, Alexandr, Béla Paizs, Martin Žabka, Marek Kuzma, Vladimír Havlíček, Anastassios E. Giannakopulos, and Peter J. Derrick. "Profiling of Cyclic Hexadepsipeptides Roseotoxins Synthesized In Vitro and In Vivo: A Combined Tandem Mass Spectrometry and Quantum Chemical Study." European Journal of Mass Spectrometry 9, no. 2 (April 2003): 105–16. http://dx.doi.org/10.1255/ejms.531.

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High-performance liquid chromatography and tandem mass spectrometry (HPLC/MS/MS) was used for the detection of cyclic hexadepsipeptides roseotoxins produced by Trichothecium roseum. Roseotoxins were found in both submerged standard cultivation on Czapek–Dox medium and in vivo cultivation extract obtained from an apple. Roseotoxin chromatographic profiles from these two experiments were compared. Product-ion collision-induced dissociation (CID) spectra obtained on an ion trap (electrospray ionisation, ESI) were used for the identification of natural roseotoxins A, B, C and of minor destruxins A

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Mangold, Kathryn E., Wei Wang, Eric K. Johnson, Druv Bhagavan, Jonathan D. Moreno, Jeanne M. Nerbonne, and Jonathan R. Silva. "Identification of structures for ion channel kinetic models." PLOS Computational Biology 17, no. 8 (August 16, 2021): e1008932. http://dx.doi.org/10.1371/journal.pcbi.1008932.

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Markov models of ion channel dynamics have evolved as experimental advances have improved our understanding of channel function. Past studies have examined limited sets of various topologies for Markov models of channel dynamics. We present a systematic method for identification of all possible Markov model topologies using experimental data for two types of native voltage-gated ion channel currents: mouse atrial sodium currents and human left ventricular fast transient outward potassium currents. Successful models identified with this approach have certain characteristics in common, suggestin

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Veetil, Aneesh T., Maulik S. Jani, and Yamuna Krishnan. "Chemical control over membrane-initiated steroid signaling with a DNA nanocapsule." Proceedings of the National Academy of Sciences 115, no. 38 (March 12, 2018): 9432–37. http://dx.doi.org/10.1073/pnas.1712792115.

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Membrane-initiated steroid signaling (MISS) is a recently discovered aspect of steroidal control over cell function that has proved highly challenging to study due to its rapidity and ultrasensitivity to the steroid trigger [Chow RWY, Handelsman DJ, Ng MKC (2010) Endocrinology 151:2411–2422]. Fundamental aspects underlying MISS, such as receptor binding, kinetics of ion-channel opening, and production of downstream effector molecules remain obscure because a pristine molecular technology that could trigger the release of signaling steroids was not available. We have recently described a protot

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Ranchoux, Benoît, Lloyd D. Harvey, Ramon J. Ayon, Aleksandra Babicheva, Sebastien Bonnet, Stephen Y. Chan, Jason X. J. Yuan, and Vinicio de Jesus Perez. "Endothelial dysfunction in pulmonary arterial hypertension: an evolving landscape (2017 Grover Conference Series)." Pulmonary Circulation 8, no. 1 (December 28, 2017): 204589321775291. http://dx.doi.org/10.1177/2045893217752912.

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Endothelial dysfunction is a major player in the development and progression of vascular pathology in pulmonary arterial hypertension (PAH), a disease associated with small vessel loss and obstructive vasculopathy that leads to increased pulmonary vascular resistance, subsequent right heart failure, and premature death. Over the past ten years, there has been tremendous progress in our understanding of pulmonary endothelial biology as it pertains to the genetic and molecular mechanisms that orchestrate the endothelial response to direct or indirect injury, and how their dysregulation can contr

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