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Articles de revues sur le sujet « Isatis indigotica »

Auteur : Grafiati

Publié le 2 juin 2025

Mis à jour le 31 juillet 2025

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1

Wang, Lunyan, Jia Liu, Yilun Dong, et al. "Phenotypic Traits, Hormonal Distribution, and Metabolite Profiling of Isatis indigotica Seeds from 21 Samples in China: A Traditional Chinese Medicinal Herb." Plants 14, no. 7 (2025): 1096. https://doi.org/10.3390/plants14071096.

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“Banlangen” (Isatis indigotica Fort., indigowoad root) is the dried root of a plant in the Cruciferae (Brassicaceae) family, which has been cultivated in China for over 2000 years. This herb has significant medicinal value and played an important therapeutic role during the COVID-19 pandemic. Isatis indigotica is widely cultivated in China, with varying seed quality across different regions. Investigating the seed quality and distribution of endogenous metabolites of Isatis indigotica from various regions is of great significance for its efficient utilization. In this study, 21 samples from Is

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Wong, Li Wen, Calvin Bok Sun Goh, and Joash Ban Lee Tan. "A Systemic Review for Ethnopharmacological Studies on Isatis indigotica Fortune: Bioactive Compounds and their Therapeutic Insights." American Journal of Chinese Medicine 50, no. 01 (2022): 161–207. http://dx.doi.org/10.1142/s0192415x22500069.

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Isatis indigotica Fortune is a biennial Chinese woad of the Cruciferae family. It is primarily cultivated in China, where it was a staple in indigo dye manufacture till the end of the 17th century. Today, I. indigotica is used primarily as a therapeutic herb in traditional Chinese medicine (TCM). The medicinal use of the plant is separated into its leaves (Da-Qing-Ye) and roots (Ban-Lan-Gen), whereas its aerial components can be processed into a dried bluish-spruce powder (Qing-Dai), following dehydration for long-term preservation. Over the past several decades, I. indigotica has been general

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Hou, Jia, Hongru Guo, Tao Du, and Mingwei Wang. "Effects of storage methods on the quality of Isatis indigotica radix based on active constituents and NIR spectra." Quality Assurance and Safety of Crops & Foods 16, no. 3 (2024): 1–9. http://dx.doi.org/10.15586/qas.v16i3.1185.

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Isatis indigotica radix is a common traditional Chinese medicine and veterinary medicine widely cultivated in China, and inappropriate storage conditions may damage its quality. The objective of this work was to investigate the changes in epigoitrin and nucleosides compounds and Near Infrared Spectra (NIR) of Isatis indigotica radix packaging under vacuum (VP), nitrogen (NP), and sealing (SP), stored at different temperatures—room temperature (SPt), refrigerator (SPr), and frozen (SPf) during 12 months of storage. After 12 months of storage, the epigoitrin concentration of I. indigotica radix

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Wu, Xiaoyun, Guowei Qin, Kung Kai Cheung, and Kin Fai Cheng. "New alkaloids from Isatis indigotica." Tetrahedron 53, no. 39 (1997): 13323–28. http://dx.doi.org/10.1016/s0040-4020(97)00846-6.

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Xu, Pei-Pei, and Ying-Na Shi. "Prevention Activity of a New Heterocycle Compound from Isatis indigotica on Hypotension After Anesthesia and Complete Chloroplast Genome Sequence." Science of Advanced Materials 14, no. 2 (2022): 367–71. http://dx.doi.org/10.1166/sam.2022.4213.

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During the operation, the use of anesthetics or analgesics and bleeding will cause hypotension on patients, thus seriously threatening the patient’s life and safety. Isatis indigotica is utilized as traditional drug, which is an important medicinal herb with various biological activities because of the presence of different secondary metabolites. The role of a new compound extracted from Isatis indigotica on hypotension after anesthesia was determined, and the internal principle was discussed simultaneously. At first, operation under anesthesia was carried out, the compound was administered fo

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Chen, Qiong, Hai-Yue Lan, Wei Peng, et al. "Isatis indigotica: a review of phytochemistry, pharmacological activities and clinical applications." Journal of Pharmacy and Pharmacology 73, no. 9 (2021): 1137–50. http://dx.doi.org/10.1093/jpp/rgab014.

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Abstract Objectives Isatis indigotica Fort. (I. indigotica) is an herbaceous plant belonging to Cruciferae family. Its leaf (IIL) and root (IIR) are commonly used in traditional Chinese medicines (TCMs) with good clinical efficacies such as clearing away heat and detoxification, cooling blood and reducing swelling. This review aimed to provide a systematic summary on the phytochemistry, pharmacology and clinical applications of I. indigotica. Key findings This plant contains alkaloids, organic acids, flavonoids, lignans, nucleosides, amino acids, and steroids. Previous pharmacological research

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Liu, Si-Fan, Bin Lin, Yu-Fei Xi, et al. "Bioactive spiropyrrolizidine oxindole alkaloid enantiomers from Isatis indigotica Fortune." Organic & Biomolecular Chemistry 16, no. 48 (2018): 9430–39. http://dx.doi.org/10.1039/c8ob02046a.

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Liu, Si-Fan, Bin Lin, Yu-Fei Xi, et al. "Correction: Bioactive spiropyrrolizidine oxindole alkaloid enantiomers from Isatis indigotica fortune." Organic & Biomolecular Chemistry 17, no. 9 (2019): 2564. http://dx.doi.org/10.1039/c9ob90032b.

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Wu, Shuang, Xiuwen Jia, Beijing Tian, et al. "Physiological and Cellular Ultrastructural Responses of Isatis indigotica Fort. under Salt Stress." Plants 13, no. 12 (2024): 1593. http://dx.doi.org/10.3390/plants13121593.

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This study aimed to analyze the effects of salt stress on the growth physiology and plant-cell ultrastructure of Isatis indigotica Fort. (I. indigotica) to evaluate its adaptability under salt stress. The effects of different concentrations of salt (NaCl; 0, 25, and 300 mmol·L−1) on the agronomic traits, activities of related enzymes, ion balance, and mesophyll-cell ultrastructure of I. indigotica were studied in a controlled pot experiment. Results showed that compared with those of the control group, the aerial-part fresh weight, underground fresh weight, tiller number, root length, root dia

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Xing, Xiangyu, Haijun Xu, Yan Dong, et al. "Genetic Analysis and Fingerprint Construction for Isatis indigotica Fort. Using SSR Markers." Current Issues in Molecular Biology 47, no. 3 (2025): 146. https://doi.org/10.3390/cimb47030146.

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Isatis indigotica Fort. is a traditional medicinal plant, which has anti-inflammatory, antioxidant, and antiviral properties. Despite the development and licensing of several cultivars in recent years, morphological similarity among cultivars complicates their identification. The genetic diversity within I. indigotica significantly impacts the biosynthesis of bioactive substances. To elucidate genetic relationships and evaluate bioactive compounds, I. indigotica cultivars were analyzed using SSR markers. A total of 109 alleles were identified across 29 cultivars at 20 SSR loci, exhibiting a ge

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Chen, Minghua, Lishe Gan, Sheng Lin, et al. "Alkaloids from the Root of Isatis indigotica." Journal of Natural Products 75, no. 6 (2012): 1167–76. http://dx.doi.org/10.1021/np3002833.

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WU, X., G. QIN, K. K. CHEUNG, and K. F. CHENG. "ChemInform Abstract: New Alkaloids from Isatis indigotica." ChemInform 29, no. 5 (2010): no. http://dx.doi.org/10.1002/chin.199805210.

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Zhang, Dongdong, Yanhong Shi, Rui Xu, et al. "Alkaloid Enantiomers from the Roots of Isatis indigotica." Molecules 24, no. 17 (2019): 3140. http://dx.doi.org/10.3390/molecules24173140.

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Five pairs of alkaloid enantiomers (1a/1b–5a/5b) were obtained from Isatis indigotica (I. indigotica) roots. Among them, 1a/1b, 2a/2b and 3a/3b were determined as three pairs of new alkaloid enantiomers. Their structures were elucidated by physicochemical properties and spectroscopic methods. The absolute configurations were deduced by comparison of their experimental circular dichroism (CD) and calculated electronic circular dichroism (ECD) spectra, as well as by single-crystal X-ray crystallography using anomalous scattering of Cu Kα radiation. Alkaloids 1a and 1b possess an unpresented carb

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Wu, Hong-Sheng, Ji Li, Su-Yun Chen, et al. "A Newly Practice to Mitigate N2O Emission from Winter Wheat Soil by Intercropping Isatis indigotica." Journal of Agricultural Science 8, no. 7 (2016): 7. http://dx.doi.org/10.5539/jas.v8n7p7.

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<p>Greenhouse gas (GHG) emitted from agricultural field was received considerable attention worldwide, depending on differed land use and cropping system. An innovative strategy to mitigate agricultural N<sub>2</sub>O by intercropping traditional Chinese medicinal herb <em>Isatis indigotica</em> in winter wheat field was assessed. By exogenously applying root exudates of <em>I. indigotica</em> in a lab incubation study, we testify and quantify whether N<sub>2</sub>O emission was inhibited.</p><p>Results demonstrated great reduct

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Shi, Guang Liang, Xue Hong Wang, Kai Guo, et al. "Effects of High-Energy Carbon Ion Irradiation on Isatis Indigotica Fort." Advanced Materials Research 317-319 (August 2011): 2056–62. http://dx.doi.org/10.4028/www.scientific.net/amr.317-319.2056.

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The aim of this study was to provide a theoretical basis for a high-energy carbon ion irradiation process for inducing mutations for selective breeding in Isatis indigotica Fort. The experiments were designed to evaluate the effects of different doses of high-energy 12C6+ ions (10-140 Gy) on physiological changes in I. indigotica seedlings. Dry seeds of I. indigotica were irradiated using different doses of 270 MeV energy 12C6+ ion beam, and the response of the subsequent seedlings was monitored using well-established indexes of physiological characteristics. Results showed that optimum result

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Cao, Yi-Wen, Ren-Jun Qu, Yu-Jing Miao, et al. "Untargeted liquid chromatography coupled with mass spectrometry reveals metabolic changes in nitrogen-deficient Isatis indigotica Fortune." Phytochemistry 166 (October 31, 2019): 1–8. https://doi.org/10.1016/j.phytochem.2019.112058.

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Cao, Yi-Wen, Qu, Ren-Jun, Miao, Yu-Jing, Tang, Xiao-Qing, Zhou, Ying, Wang, Lei, Geng, Li (2019): Untargeted liquid chromatography coupled with mass spectrometry reveals metabolic changes in nitrogen-deficient Isatis indigotica Fortune. Phytochemistry 166: 1-8, DOI: 10.1016/j.phytochem.2019.112058, URL: http://dx.doi.org/10.1016/j.phytochem.2019.112058

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Jiang, Xu-Wen, Cheng-Ran Zhang, Wei-Hua Wang, Guang-Hai Xu, and Hai-Yan Zhang. "Seed Priming Improves Seed Germination and Seedling Growth of Isatis indigotica Fort. under Salt Stress." HortScience 55, no. 5 (2020): 647–50. http://dx.doi.org/10.21273/hortsci14854-20.

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The effects of CaCl2, GA3, and H2O2 priming on Isatis indigotica Fort. seed germination characteristics, seedling growth parameters, and antioxidant enzyme activities under salt stress were investigated. NaCl had an adverse effect on the germination and seedling performance of I. indigotica. However, these three priming agents alleviated salt stress by increasing the germination percentage, improving seed vigor, accelerating germination velocity, and establishing strong seedlings. The optimal concentrations were 15 g/L for CaCl2, 0.2 g/L for GA3, and 40 mm for H2O2. Seed priming treatments enh

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Ma, Yanqin, Yanhong Lan, Ju Li, et al. "Characterization of MADS-Box Gene Family in Isatis indigotica and Functional Study of IiAP1 in Regulating Floral Transition and Formation." Plants 14, no. 1 (2025): 129. https://doi.org/10.3390/plants14010129.

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In flowering plants, MADS-box genes play regulatory roles in flower induction, floral initiation, and floral morphogenesis. Isatis indigotica (I. indigotica) is a traditional Chinese medicinal plant. However, available information concerning MADS-box genes in I. indigotica is insufficient. Based on the sequencing data of the I. indigotica transcriptome, we identified MADS-box gene-encoding transcription factors that have been shown to play critical roles in developmental processes. In this study, 102 I. indigotica MADS-box genes were identified and categorized into type I (Mα, Mβ, and Mγ) and

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Qiu, Yu-Fei, Qi Jia, Shao-Jiang Song, and Xiao-Bo Wang. "Alkaloids in Isatis indigotica and their chemotaxonomic significance." Biochemical Systematics and Ecology 113 (April 2024): 104800. http://dx.doi.org/10.1016/j.bse.2024.104800.

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Wang, Pan, Dong Liu, Fu-Hong Yang, et al. "Identification of key gene networks controlling vernalization development characteristics of Isatis indigotica by full-length transcriptomes and gene expression profiles." Physiology and Molecular Biology of Plants 27, no. 12 (2021): 2679–93. http://dx.doi.org/10.1007/s12298-021-01110-2.

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AbstractIsatis indigotica Fort., as a common Chinese medicinal raw material, will lose its medicinal value if it blooms early, so it is highly valuable to clarify the induction mechanism of the vernalization of I. indigotica at low temperature. In this study, the concentrations of soluble sugar, proline, glutathione and zeatin in two germplasms of I. indigotica with different degrees of low temperature tolerance (Y1 and Y2) were determined at 10 days, 20 days and 30 days of low-temperature treatment, and the full-length transcriptome of 24 samples was sequenced by Nanopore sequencing with Oxfo

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Krivogorsky, Bogdana, Peter Grundt, Robert Yolken, and Lorraine Jones-Brando. "Inhibition of Toxoplasma gondii by Indirubin and Tryptanthrin Analogs." Antimicrobial Agents and Chemotherapy 52, no. 12 (2008): 4466–69. http://dx.doi.org/10.1128/aac.00903-08.

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ABSTRACT New drugs are needed for treatment of Toxoplasma gondii infections. We tested derivatives of principles found in Isatis indigotica for in vitro efficacy against T. gondii infection. Indirubin-3′-oxime analogs showed modest micromolar activity, while tryptanthrin derivatives displayed 50% inhibitory doses in the low nanomolar range. Tryptanthrins have potential as anti-Toxoplasma infection therapeutics.

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Xi, Yu-Fei, Ming Bai, Xin Zhang, et al. "Insight into tetrahydrofuran lignans from Isatis indigotica fortune with neuroprotective and acetylcholinesterase inhibitor activity." Phytochemistry 208 (April 30, 2023): 113609. https://doi.org/10.1016/j.phytochem.2023.113609.

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Xi, Yu-Fei, Bai, Ming, Zhang, Xin, Hou, Zi-Lin, Lin, Bin, Yao, Guo-Dong, Lou, Li-Li, Wang, Xiao-Bo, Song, Shao-Jiang, Huang, Xiao-Xiao (2023): Insight into tetrahydrofuran lignans from Isatis indigotica fortune with neuroprotective and acetylcholinesterase inhibitor activity. Phytochemistry (113609) 208: 113609, DOI: 10.1016/j.phytochem.2023.113609, URL: http://dx.doi.org/10.1016/j.phytochem.2023.113609

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Bai, Yu, Ying Zhou, Xiaoqing Tang, Yu Wang, Fangquan Wang, and Jie Yang. "De Novo Transcriptome Assembly of Isatis indigotica at Reproductive Stages and Identification of Candidate Genes Associated with Flowering Pathways." Journal of the American Society for Horticultural Science 143, no. 1 (2018): 56–66. http://dx.doi.org/10.21273/jashs04232-17.

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The appropriate timing of bolting and flowering is one of the keys to the reproductive success of Isatis indigotica. Several flowering regulatory pathways have been reported in plant species, but we know little about flowering regulatory in I. indigotica. In the present study, we performed RNA-seq and annotated I. indigotica transcriptome using RNA from five tissues (leaves, roots, flowers, fruit, and stems). Illumina sequencing generated 149,907,857 high-quality clean reads and 124,508 unigenes were assembled from the sequenced reads. Of these unigenes, 88,064 were functionally annotated by B

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Tu, Y. Q., J. Sun, X. H. Ge, and Z. Y. Li. "Production and genetic analysis of partial hybrids from intertribal sexual crosses between Brassica napus and Isatis indigotica and progenies." Genome 53, no. 2 (2010): 146–56. http://dx.doi.org/10.1139/g09-093.

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With the dye and medicinal plant Isatis indigotica (2n = 14) as pollen parent, intertribal sexual hybrids with Brassica napus (2n = 38, AACC) were obtained and characterized. Among a lot of F1 plants produced, only five hybrids (H1–H5) were distinguished morphologically from female B. napus parents by showing low fertility and some characters of I. indigotica, and also by having different chromosome numbers. H1–H4 had similar but variable chromosome numbers in their somatic and meiotic cells (2n = 25–30), and H5 had 2n = 19, the same number as the haploid of B. napus. GISH analysis of the cell

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Liu, Yu-Feng, Ming-Hua Chen, Sheng Lin, et al. "Indole alkaloid glucosides from the roots of Isatis indigotica." Journal of Asian Natural Products Research 18, no. 1 (2015): 1–12. http://dx.doi.org/10.1080/10286020.2015.1117452.

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Guo, Qinglan, Chengbo Xu, Minghua Chen, et al. "Sulfur-enriched alkaloids from the root of Isatis indigotica." Acta Pharmaceutica Sinica B 8, no. 6 (2018): 933–43. http://dx.doi.org/10.1016/j.apsb.2018.08.005.

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Tang, Feng, Yongde Yue, Rimao Hua, Shimei Ge, and Jie Tang. "Development of Methods for Determination of the Residues of 15 Pesticides in Medicinal Herbs Isatis indigotica Fort. by Capillary Gas Chromatography with Electron Capture or Flame Photometric Detection." Journal of AOAC INTERNATIONAL 88, no. 3 (2005): 720–28. http://dx.doi.org/10.1093/jaoac/88.3.720.

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Abstract Two multiresidue methods were developed for the determination of 15 pesticides (organochlorines, organphosphorus compounds, pyrethroids, and fungicides) in medicinal herbs Isatis indigotica Fort. and its formulations. The analytical procedure is based on ultrasonic assisted extraction and liquid-liquid extraction (LLE). After solvents were added, the raw material or granule sample was sonicated in an ultrasonic water bath and then centrifuged, filtered, and cleaned up by LLE. The infusion sample was extracted with petroleum ether by LLE. The pesticide residues were determined by capil

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Gao, J., Y. N. Liu, N. Nan, B. H. Lu, W. Y. Xia, and X. Y. Wu. "Alternaria brassicicola Causes a Leaf Spot on Isatis indigotica in China." Plant Disease 98, no. 10 (2014): 1431. http://dx.doi.org/10.1094/pdis-03-14-0242-pdn.

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Chinese woad (Isatis indigotica) is a biennial herb in the Brassicaceae that is widely cultivated in China. Extracts from the roots and leaves have potential pharmaceutical use for treatment of flu, encephalitis, measles, hepatitis, and mumps (2). In June 2012, a leaf spot was observed on 1-year-old plants of I. indigotica in the medicinal garden of Jilin Agricultural University, Changchun, Jilin Province, China. More than 50% of the leaves and 100% of the plants in the garden were symptomatic. In the initial stage of infection, irregular to circular, dark gray spots, each surrounded by a chlo

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Guo, Yanhong, Yutian Han, Jinxiang Gao, et al. "Rapid Identification of Alien Chromosome Fragments and Tracing of Bioactive Compound Genes in Intergeneric Hybrid Offspring Between Brassica napus and Isatis indigotica Based on AMAC Method." International Journal of Molecular Sciences 26, no. 5 (2025): 2091. https://doi.org/10.3390/ijms26052091.

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Distant hybridization between Brassica napus and related genera serves as an effective approach for rapeseed germplasm innovation. Isatis indigotica, a wild relative of Brassica, has emerged as a valuable genetic resource for rapeseed improvement due to its medicinal properties. This study employed anchor mapping of alien chromosomal fragment localization (AMAC) method to efficiently identify alien chromosomal fragments in the progeny derived from distant hybridization between I. indigotica and Brassica napus, ‘Songyou No. 1’. Based on the AMAC method, we developed 193,101 IP and SSR markers u

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Kim, Jin Hyeok, Dan Gao, Won Seok Jeong, et al. "Anti-Wrinkle Effect of Isatis indigotica Leaf Extract: Evaluation of Antioxidant, Anti-Inflammation, and Clinical Activity." Antioxidants 10, no. 9 (2021): 1339. http://dx.doi.org/10.3390/antiox10091339.

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Isatis indigotica leaf is an oriental herbal medicine that has been known for various pharmacological effects. However, its anti-wrinkle activity has not been fully evaluated. Therefore, we evaluated the anti-wrinkle effect of I. indigotica leaf extract on human skin. The purified extract inhibited 85.4% of 2,2-diphenyl-1-1picrylhydrazyl and 72.2% of 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt radicals at a concentration of 1 mg/mL. Nitrite production was reduced by 30% after treatment with 50 μg/mL of extract. Three fractions from the extract downregulated the mRNA

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Li, Qing, Junfeng Chen, Peng Di, Ying Xiao, Lei Zhang, and Wansheng Chen. "Discovery and analysis of GRAS gene family in Isatis indigotica." European Journal of Integrative Medicine 6, no. 6 (2014): 727–28. http://dx.doi.org/10.1016/j.eujim.2014.09.092.

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Li, Da-Wei, Qing-Lan Guo, Xian-Hua Meng, Cheng-Gen Zhu, Cheng-Bo Xu, and Jian-Gong Shi. "Two pairs of unusual scalemic enantiomers from Isatis indigotica leaves." Chinese Chemical Letters 27, no. 12 (2016): 1745–50. http://dx.doi.org/10.1016/j.cclet.2016.08.006.

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Chen, Junfeng, Yun Wang, Fengying Liang, et al. "IiUGT71B2 catalyzes lignan glycosylation in Isatis indigotica with substrates specificity." Industrial Crops and Products 195 (May 2023): 116483. http://dx.doi.org/10.1016/j.indcrop.2023.116483.

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Wang, Yucai, Hengjia Zhang, Zhongsheng He, et al. "Effects of Regulated Deficit Irrigation on Yield and Quality of Isatis indigotica in a Cold and Arid Environment." Water 14, no. 11 (2022): 1798. http://dx.doi.org/10.3390/w14111798.

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Although regulated deficit irrigation may improve crop yields, little research has been conducted on the effects of water deficits on Isatis indigotica, a popular herbal medicine. Field experiments were conducted in 2016 and 2017 to study the effects of regulated deficit irrigation on the net photosynthetic rate, yield, water use efficiency (WUE), and quality of I. indigotica in northwest China. Plants at the vegetative and fleshy root growth stages were subjected to mild, moderate, and severe water deficits, and their photosynthetic physiological indexes, yield, and WUE were measured. Moderat

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Yang, Lu, Huiqiang Wang, Haiyan Yan, Kun Wang, Shuo Wu, and Yuhuan Li. "(−)-Lariciresinol Isolated from the Roots of Isatis indigotica Fortune ex Lindl. Inhibits Hepatitis B Virus by Regulating Viral Transcription." Molecules 27, no. 10 (2022): 3223. http://dx.doi.org/10.3390/molecules27103223.

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Chronic hepatitis induced by hepatitis B virus (HBV) infection is a serious public health problem, leading to hepatic cirrhosis and liver cancer. Although the currently approved medications can reliably decrease the virus load and prevent the development of hepatic diseases, they fail to induce durable off-drug control of HBV replication in the majority of patients. The roots of Isatis indigotica Fortune ex Lindl., a traditional Chinese medicine, were frequently used for the prevention of viral disease in China. In the present study, (−)-lariciresinol ((−)-LRSL), isolated from the roots of Isa

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Zhou, Jie, Lei Fang, Xiao Wang, Lanping Guo, and Luqi Huang. "Effects of Smoke-water on Photosynthetic Characteristics of Isatis indigotica Seedlings." Sustainable Agriculture Research 2, no. 2 (2012): 24. http://dx.doi.org/10.5539/sar.v2n2p24.

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<p>Smoke-water (SW) had been reported to improve the growth of <em>Isatis indigotica</em>, a Chinese medicinal plant. However, there were very few reports on the mechanism of smoke-water improving plant growth. In this study the effects of smoke-water on the photosynthetic characteristics of <em>I.</em><em> indigotica</em> seedlings were investigated for the purpose of understanding the mechanism behind this improved plant growth. The results showed that net photosynthetic rate (<em>P<sub>n</sub></em>) was increased by smoke-wat

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Zhang, Lei, Tiefeng Xu, Xiaofen Sun, Hanming Zhang, Tianlin Tang, and Kexuan Tang. "Factors influencing shoot regeneration from cotyledons of tetraploid Isatis indigotica fort." In Vitro Cellular & Developmental Biology - Plant 39, no. 5 (2003): 459–62. http://dx.doi.org/10.1079/ivp2003447.

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Liu, Yufeng, Xiaoliang Wang, Minghua Chen, Sheng Lin, Li Li, and Jiangong Shi. "Three pairs of alkaloid enantiomers from the root of Isatis indigotica." Acta Pharmaceutica Sinica B 6, no. 2 (2016): 141–47. http://dx.doi.org/10.1016/j.apsb.2016.01.003.

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Wu, Jia, Hafiz Muhammad Khalid Abbas, Jiale Li, et al. "Cell Membrane-Interrupting Antimicrobial Peptides from Isatis indigotica Fortune Isolated by a Bacillus subtilis Expression System." Biomolecules 10, no. 1 (2019): 30. http://dx.doi.org/10.3390/biom10010030.

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The situation of drug resistance has become more complicated due to the scarcity of plant resistance genes, and overcoming this challenge is imperative. Isatis indigotica has been used for the treatment of wounds, viral infections, and inflammation for centuries. Antimicrobial peptides (AMPs) are found in all classes of life ranging from prokaryotes to eukaryotes. To identify AMPs, I. indigotica was explored using a novel, sensitive, and high-throughput Bacillus subtilis screening system. We found that IiR515 and IiR915 exhibited significant antimicrobial activities against a variety of bacter

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Tozzi, Sabrina, Bartolomeo Lercari, and Luciana G. Angelini. "Light Quality Influences Indigo Precursors Production and Seed Germination in Isatis tinctoria L. and Isatis indigotica Fort¶." Photochemistry and Photobiology 81, no. 4 (2005): 914. http://dx.doi.org/10.1562/2004-08-03-ra-258r1.1.

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Tozzi, Sabrina, Bartolomeo Lercari, and Luciana G. Angelini. "Light Quality Influences Indigo Precursors Production and Seed Germination in Isatis tinctoria L. and Isatis indigotica Fort.¶." Photochemistry and Photobiology 81, no. 4 (2007): 914–19. http://dx.doi.org/10.1111/j.1751-1097.2005.tb01462.x.

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Gao, Guanzhen, Qian Wang, Jianwu Zhou, Huiqin Wang, Lijing Ke, and Pingfan Rao. "Isolation and Identification of a Polygalacturonase Inhibiting Protein from Isatidis root." Natural Product Communications 10, no. 2 (2015): 1934578X1501000. http://dx.doi.org/10.1177/1934578x1501000214.

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Isatis indigotica Fort. (Chinese woad) has been widely used as a dye- and medicinal-plant in traditional Chinese medicine. Although I. indigotica has been cultivated in various regions across China in recent years, its innate immunity is little known. In this study, a protein with MW 37.5 kDa was purified from the extract of fresh Isatidis roots by SP-5PW cationic exchange and POROS HP2 hydrophobic interaction chromatography. The N-terminal amino acid sequence of the purified protein was subsequently determined as T-D-L-C-H-K-D-P-K-N-T-L-L by Edman degradation. The N-terminal sequence and PG i

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Qu, Renjun, Yiwen Cao, Xiaoqing tang, Liqiong Sun, Lian Wei, and Kangcai Wang. "Identification and expression analysis of the WRKY gene family in Isatis indigotica." Gene 783 (May 2021): 145561. http://dx.doi.org/10.1016/j.gene.2021.145561.

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Guo, Qihui, Yanzhi Sun, Qingjiu Tang, Hongchao Zhang, and Zhihong Cheng. "Isolation, identification, biological estimation, and profiling of glucosinolates in Isatis indigotica roots." Journal of Liquid Chromatography & Related Technologies 43, no. 15-16 (2020): 645–56. http://dx.doi.org/10.1080/10826076.2020.1780605.

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Tang, X. Q., H. W. Tan, S. L. Shi, et al. "Characterization of Transcriptome Expression: The Response of Isatis indigotica to Salt Stress." Russian Journal of Plant Physiology 67, no. 6 (2020): 1135–43. http://dx.doi.org/10.1134/s1021443720060163.

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Yuan, Xiangyang, Liguang Zhang, Na Ning, et al. "Photosynthetic Physiological Response of Radix Isatidis (Isatis indigotica Fort.) Seedlings to Nicosulfuron." PLoS ONE 9, no. 8 (2014): e105310. http://dx.doi.org/10.1371/journal.pone.0105310.

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Tang, Xiaoqing, Yunhua Xiao, Tingting Lv, et al. "High-Throughput Sequencing and De Novo Assembly of the Isatis indigotica Transcriptome." PLoS ONE 9, no. 9 (2014): e102963. http://dx.doi.org/10.1371/journal.pone.0102963.

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Meng, Ling-Jie, Qing-Lan Guo, Cheng-Bo Xu, et al. "Diglycosidic indole alkaloid derivatives from an aqueous extract of Isatis indigotica roots." Journal of Asian Natural Products Research 19, no. 6 (2017): 529–40. http://dx.doi.org/10.1080/10286020.2017.1320547.

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ZHANG, Lei, Qing LI, Jun-Feng CHEN, and Wan-Sheng CHEN. "Computational identification and systematic classification of novel GRAS genes in Isatis indigotica." Chinese Journal of Natural Medicines 14, no. 3 (2016): 161–76. http://dx.doi.org/10.1016/s1875-5364(16)30013-9.

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Li, Ping, Hongying Li, Yuzheng Zong, Frank Yonghong Li, Yuanhuai Han, and Xingyu Hao. "Photosynthesis and metabolite responses of Isatis indigotica Fortune to elevated [CO 2 ]." Crop Journal 5, no. 4 (2017): 345–53. http://dx.doi.org/10.1016/j.cj.2017.03.007.

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