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Littérature scientifique sur le sujet « IVIVC »

Auteur : Grafiati

Publié le 4 juin 2021

Mis à jour le 26 juillet 2025

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Articles de revues sur le sujet "IVIVC"

Polli, James E. "IVIVR versus IVIVC." Dissolution Technologies 7, no. 3 (2000): 6–8. http://dx.doi.org/10.14227/dt070300p6.

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Shazia Ashraf, Azka Ali, Uzma Noreen, and Iqra Abdullah Jan. "In vitro-in vivo correlation (IVIVC) of different parameters of dosage form." Journal of Contemporary Pharmacy 5, no. 1 (2021): 28–32. http://dx.doi.org/10.56770/jcp2021514.

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Researchers can achieve rapid drug production by discovering a mathematical link between bioavailability and dissolution testing that leads to the principle of in vitro - in vivo correlation (IVIVC). IVIVC is a mathematical model which from its in vitro output can be used to estimate in vivo action. Level A correlation is widely recognized by the regulatory agencies among all the five stages of correlation. IVIVC's suitability is demonstrated by the Biopharmaceutical Classification System (BCS). In the estimation of correlations, dissolution process design plays a central role. Other important

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Rohankumar Patel and Ankur Patel. "In vivo–In Vitro correlation (IVIVC) in drug development: bridging preclinical and clinical outcomes for regulatory approvals." World Journal of Advanced Research and Reviews 22, no. 2 (2024): 2311–28. https://doi.org/10.30574/wjarr.2024.22.2.1197.

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The pharmacological discipline of In vivo–In Vitro Correlation (IVIVC) plays a crucial role in drug development, creating essential relationships to forecast in vivo PK results from measuring In Vitro drug release profiles. IVIVC models not only prove essential for formulating drugs properly but also significantly reduce time and costs during regulatory processes, thereby limiting extensive clinical testing requirements. These models can predict live performance outcomes through laboratory results, leading to consistent therapeutic outcomes between different medications. The relation between I

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Mumtaz, Hina, Muhammad Asim Farooq, Zainab Batool, Anam Ahsan, and Ashikujaman Syed. "Significance of In-Vitro and In-Vivo Correlation in Drug Delivery System." Research in Pharmacy and Health Sciences 4, no. 4 (2018): 523–31. http://dx.doi.org/10.32463/rphs.2018.v04i04.23.

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The main purpose of development pharmaceutical dosage form is to find out the in vivo and in vitro behavior of dosage form. This challenge is overcome by implementation of in-vivo and in-vitro correlation. Application of this technique is economical and time saving in dosage form development. It shortens the period of development dosage form as well as improves product quality. IVIVC reduce the experimental study on human because IVIVC involves the in vivo relevant media utilization in vitro specifications. The key goal of IVIVC is to serve as alternate for in vivo bioavailability studies and

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Lee, Dong-Seok, Dong Wook Kang, Go-Wun Choi, Han-Gon Choi, and Hea-Young Cho. "Development of Level A In Vitro–Vivo Correlation for Electrosprayed Microspheres Containing Leuprolide: Physicochemical, Pharmacokinetic, and Pharmacodynamic Evaluation." Pharmaceutics 12, no. 1 (2020): 36. http://dx.doi.org/10.3390/pharmaceutics12010036.

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This study optimized the preparation of electrosprayed microspheres containing leuprolide and developed an in vitro–in vivo correlation (IVIVC) model that enables mutual prediction between in vitro and in vivo dissolution. The pharmacokinetic (PK) and pharmacodynamic (PD) study of leuprolide was carried out in normal rats after subcutaneous administration of electrosprayed microspheres. The parameters of the IVIVC model were estimated by fitting the PK profile of Lucrin depot® to the release compartment of the IVIVC model, thus the in vivo dissolution was predicted from the in vitro dissolutio

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Tosca, Elena M., Maurizio Rocchetti, Elena Pérez, et al. "In Vitro–In Vivo Correlation (IVIVC) Population Modeling for the In Silico Bioequivalence of a Long-Acting Release Formulation of Progesterone." Pharmaceutics 13, no. 2 (2021): 255. http://dx.doi.org/10.3390/pharmaceutics13020255.

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Health authorities carefully evaluate any change in the batch manufacturing process of a drug before and after regulatory approval. In the absence of an adequate in vitro–in vivo correlation (Level A IVIVC), an in vivo bioequivalence (BE) study is frequently required, increasing the cost and time of drug development. This study focused on developing a Level A IVIVC for progesterone vaginal rings (PVRs), a dosage form designed for the continuous delivery in vivo. The pharmacokinetics (PK) of four batches of rings charged with 125, 375, 750 and 1500 mg of progesterone and characterized by differ

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Ajeh, Isaac J., Galadima I. Hayatu, and Ekeh I. Ezekiel. "Computational prediction of pharmacokinetic parameters as an in vitro approach for assessing paracetamol tablets for IVIVC; a strategy in COVID-19 disruptive times." Journal of Phytomedicine and Therapeutics 21, no. 2 (2022): 835–45. http://dx.doi.org/10.4314/jopat.v21i2.6.

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In vitro-in vivo correlation (IVIVC) is a desirable attribute for any drug dissolution test to establish relevance and confidence in evaluating the quality and safety of products. The pharmacokinetic parameters of paracetamol have been studied extensively but information about the IVIVC is scanty and mostly controversial; this justifies its choice as a model drug for this study. This work is aimed to evaluate and compare the IVIVC dissolution profile of different brands of paracetamol tablets using authentic pharmacokinetic parameters such as; maximum observed dug concentration (Cmax), time to

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Čulen, Martin, Paweł K. Tuszyński, Sebastian Polak, Renata Jachowicz, Aleksander Mendyk, and Jiří Dohnal. "Development ofIn Vitro-In VivoCorrelation/Relationship Modeling Approaches for Immediate Release Formulations Using Compartmental Dynamic Dissolution Data from “Golem”: A Novel Apparatus." BioMed Research International 2015 (2015): 1–13. http://dx.doi.org/10.1155/2015/328628.

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Different batches of atorvastatin, represented by two immediate release formulation designs, were studied using a novel dynamic dissolution apparatus, simulating stomach and small intestine. A universal dissolution method was employed which simulated the physiology of human gastrointestinal tract, including the precise chyme transit behavior and biorelevant conditions. The multicompartmental dissolution data allowed direct observation and qualitative discrimination of the differences resulting from highly pH dependent dissolution behavior of the tested batches. Further evaluation of results wa

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Prieto-Escolar, Mercedes, Juan J. Torrado, Covadonga Álvarez, et al. "One and Two-Step In Vitro-In Vivo Correlations Based on USP IV Dynamic Dissolution Applied to Four Sodium Montelukast Products." Pharmaceutics 13, no. 5 (2021): 690. http://dx.doi.org/10.3390/pharmaceutics13050690.

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Montelukast is a weak acid drug characterized by its low solubility in the range of pH 1.2 to 4.5, which may lead to dissolution-limited absorption. The aim of this paper is to develop an in vivo predictive dissolution method for montelukast and to check its performance by establishing a level-A in vitro-in vivo correlation (IVIVC). During the development of a generic film-coated tablet formulation, two clinical trials were done with three different experimental formulations to achieve a similar formulation to the reference one. A dissolution test procedure with a flow-through cell (USP IV) wa

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Lee, Da Young, Soyoung Shin, Tae Hwan Kim, and Beom Soo Shin. "Establishment of Level a In Vitro–In Vivo Correlation (IVIVC) via Extended DoE-IVIVC Model: A Donepezil Case Study." Pharmaceutics 14, no. 6 (2022): 1226. http://dx.doi.org/10.3390/pharmaceutics14061226.

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This study aimed to establish an extended design of experiment (DoE)-in vitro in vivo correlation (IVIVC) model that defines the relationship between formulation composition, in vitro dissolution, and in vivo pharmacokinetics. Fourteen sustained-release (SR) tablets of a model drug, donepezil, were designed by applying a mixture design of DoE and prepared by the wet granulation method. The in vitro dissolution patterns of donepezil SR tablets were described by Michaelis–Menten kinetics. The mathematical relationship describing the effects of SR tablet compositions on the in vitro dissolution p

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Thèses sur le sujet "IVIVC"

Wingert, Nathalie Ribeiro. "Desenvolvimento e validação de métodos analíticos e estudos de estabilidade da rivaroxabana." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2015. http://hdl.handle.net/10183/149500.

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A análise de fármacos é fundamental nas diversas fases do desenvolvimento farmacêutico, tais como estudos de formulação, estabilidade e controle de qualidade do produto. A rivaroxabana (RIV) é um anticoagulante de uso oral indicado para prevenção da formação de coágulos venosos. A literatura pesquisada apresenta poucos relatos de determinação quantitativa e de estudos de estabilidade do fármaco em comprimidos. E ainda nenhum método analítico em compêndios oficiais Diante do exposto, o objetivo deste trabalho foi desenvolver e validar métodos analíticos para determinação qualitativa e quantitat

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Bergstrand, Martin. "Application of Mixed-Effect Modeling to Improve Mechanistic Understanding and Predictability of Oral Absorption." Doctoral thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-149314.

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Several sophisticated techniques to study in vivo GI transit and regional absorption of pharmaceuticals are available and increasingly used. Examples of such methods are Magnetic Marker Monitoring (MMM) and local drug administration with remotely operated capsules. Another approach is the paracetamol and sulfapyridine double marker method which utilizes observed plasma concentrations of the two substances as markers for GI transit. Common for all of these methods is that they generate multiple types of observations e.g. tablet GI position, drug release and plasma concentrations of one or more

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Delvadia, Renishkumar. "In vitro methods to predict aerosol drug deposition in normal adults." VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/314.

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This research was aimed at the development and validation of new in vitro methods capable of predicting in vivo drug deposition from dry powder inhalers, DPIs, in lung-normal human adults. Three physical models of the mouth, throat and upper airways, MT-TB, were designed and validated using the anatomical literature. Small, medium and large versions were constructed to cover approximately 95% of the variation seen in normal adult humans of both genders. The models were housed in an artificial thorax and used for in vitro testing of drug deposition from Budelin Novolizer DPIs using a breath

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Carlert, Sara. "Investigation and Prediction of Small Intestinal Precipitation of Poorly Soluble Drugs : a Study Involving in silico, in vitro and in vivo Assessment." Doctoral thesis, Uppsala universitet, Institutionen för farmaci, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-178053.

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The main objectives of the present project were to increase the understanding of small intestinal precipitation of poorly soluble pharmaceutical drugs, investigate occurrence of crystalline small intestinal precipitation and effects of precipitation on absorption. The aim was to create and evaluate methods of predicting crystalline small intestinal drug precipitation using in vivo, in vitro and in silico models. In vivo small intestinal precipitation from highly supersaturated solutions of two weakly basic model drugs, AZD0865 and mebendazole, was investigated in humans and canine models. Pote

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Long, Chiau Ming. "Biopharmaceutical considerations and in vitro-in vivo correlations (IVIVCs) for orally administered amorphous formulations." Thesis, University of Bath, 2014. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.629670.

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Dissolution testing and physiological based pharmacokinetic modeling are the essential methods during drug development. However, there is a lack of a sound approach and understanding of the parameter that controls dissolution and absorption of amorphous formulations. Robust dissolution conditions and setup and PBPK models that have a predictability of in vivo results will expedite and facilitate the drug development process. In this project, cefuroxime axetil, CA (Zinnat® as the amorphous formulations); itraconazole, ITR (Sporanox® as the amorphous formulation) and a compound undergoing clinic

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MASSIRONI, ANDREA. "Search for a Higgs Boson in the H - > WW - > IvIv channel at CMS." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2013. http://hdl.handle.net/10281/40097.

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In this thesis work, the search for a Higgs boson at CMS in the WW fully leptonic decay channel is presented. Two different production mechanisms have been analysed: the Vector Boson Fusion (VBF) and the Higgs-strahlung (VH). Given the leptonic decays of WW, in order to guarantee a good electron reconstruction and identification, the electromagnetic calorimeter alignment has been studied. In addition, both the VBF and the VH analyses relies on the capability of CMS to reconstruct jets: one of the first measurements of CMS, with data collected during 2010 run, looking at the simultaneous pro

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Da, Silva Franck. "Amélioration de la prédiction de la clairance métabolique via l’utilisation de modèles hépatiques innovants." Thesis, Montpellier, 2018. http://www.theses.fr/2018MONTT083.

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La sélection des meilleurs candidats médicament se base sur des choix multiparamétriques réunissant l’efficacité potentielle, les caractéristiques ADME et le profil de sécurité des nouvelles entités chimiques. En ce sens, la prédiction précoce de la pharmacocinétique est élémentaire pour orienter les prises de décision et donner un cap pertinent aux projets. En raison de son rôle central dans le devenir des médicaments, la clairance métabolique médiée principalement par le foie est l’un des paramètres les plus importants. L’objectif de ce projet était d’améliorer la prédiction de la clairance

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Harwood, Matthew Dillston. "Towards a fully mechanistic prediction of oral drug absorption : investigating intestinal transporter abundance & function relationships." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/towards-a-fully-mechanistic-prediction-of-oral-drug-absorption-investigating-intestinal-transporter-abundance-and-function-relationships(a211b130-b8ac-4ce3-bf8f-728cf08df216).html.

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Background: Elucidating the role of intestinal drug transporter function in drug development is crucial, as transporter proteins can impact on drug absorption, efficacy and adverse events. In Vitro-In Vivo Extrapolation linked to Physiologically-Based Pharmacokinetic (IVIVE-PBPK) models aim to predict the in vivo impact of transporters from in vitro cell–based transport data and expression-based scaling factors. Currently, these models depend on relative measurements of transporter expression i.e., mRNA or immunoblotting. There is a critical need for physiologically relevant measures of transp

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Reddyhoff, Dennis. "Mathematical modelling of acetaminophen induced hepatotoxicity." Thesis, Loughborough University, 2016. https://dspace.lboro.ac.uk/2134/23008.

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Acetaminophen, known as paracetamol in the UK and Tylenol in the United States, is a widespread and commonly used painkiller all over the world. Taken in large enough doses, however, it can cause fatal liver damage. In the U.S., 56000 people are admitted to hospital each year due to acetaminophen overdose and its related effects, at great cost to healthcare services. In this thesis we present a number of different models of acetaminophen metabolism and toxicity. Previously, models of acetaminophen toxicity have been complex and due to this complexity, do not lend themselves well to more advanc

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Maharao, Neha V. "Inhibition of Oxidative and Conjugative Metabolism of Buprenorphine Using Generally Recognized As Safe (GRAS) Compounds or Components of Dietary Supplements." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4752.

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This dissertation aimed at developing an inhibitor strategy to improve the oral bioavailability (Foral) and systemic exposure (AUC∞) of buprenorphine (BUP) as well as reduce the variability associated with them. Twenty-seven generally recognized as safe (GRAS) compounds or dietary substances were evaluated for their potential to inhibit the oxidative and conjugative metabolism of BUP, using pooled human intestinal and liver microsomes. In both the organs, oxidation appeared to be the major metabolic pathway with a 6 fold (intestine) and 4 fold (liver) higher intrinsic clearance than glucuronid

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Livres sur le sujet "IVIVC"

Zaman, Halimah Badioze. Visual Informatics: Bridging Research and Practice: First International Visual Informatics Conference, IVIC 2009 Kuala Lumpur, Malaysia, November 11-13, 2009 Proceedings. Springer-Verlag Berlin Heidelberg, 2009.

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Monterroso, Matilde Ivic de. Ciencia y técnica maya: Con la colaboración del Consejo Nacional de Ancianos Principales y Guías Espirituales Mayas, Xincas y Garífunas ; editores, Matilde Ivic de Monterroso, Iván Azurdia Bravo. Fundación Solar, 2008.

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A, Redburn Dianna, Pasantes-Morales Herminia, Instituto Venezolano de Investigaciónes Científicas., American Society for Neurochemistry, and International Society for Neurochemistry, eds. Extracellular and intracellular messengers in the vertebrate retina: Based primarily on the proceedings of a satellite symposium of the Instituto Venezolano de Investigaciónes Científicas (IVIC) meeting held in Caracas, Venezuela, May 1987. A.R. Liss, 1989.

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Ivic, Sanja. Concept of European Values. The Rowman & Littlefield Publishing Group, 2023. https://doi.org/10.5040/9781978729384.

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The Concept of European Values: Creating a New Narrative for Europe offers a philosophical analysis of the concept of European values from its origin to the present day. This book rethinks European values in light of the crises—economic, political, migration, identity, and pandemic—that the European Union (EU) has faced from 2008 until today and analyzes EU initiatives to create a new narrative for Europe. Sanja Ivic reexamines the concept of European values as well as the philosophical and political assumptions on which this concept is based. In times of crisis, the EU has shown a lack of sol

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Shih, Timothy K., Alan F. Smeaton, Halimah Badioze Zaman, et al. Advances in Visual Informatics: 6th International Visual Informatics Conference, IVIC 2019, Bangi, Malaysia, November 19–21, 2019, Proceedings. Springer, 2019.

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Olivier, Patrick, Timothy K. Shih, Halimah Badioze Zaman, Sergio Velastin, and Robinson Peter. Advances in Visual Informatics: Third International Visual Informatics Conference, IVIC 2013, Selangor, Malaysia, November 13-15, 2013, Proceedings. Springer, 2013.

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Shih, Timothy K., Alan F. Smeaton, Halimah Badioze Zaman, Sergio Velastin, and Tada Terutoshi. Advances in Visual Informatics: 7th International Visual Informatics Conference, IVIC 2021, Kajang, Malaysia, November 23-25, 2021, Proceedings. Springer International Publishing AG, 2021.

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Shih, Timothy K., Halimah Badioze Zaman, Sergio Velastin, Alan Smeaton, and Robinson Peter. Advances in Visual Informatics: 4th International Visual Informatics Conference, IVIC 2015, Bangi, Malaysia, November 17-19, 2015, Proceedings. Springer London, Limited, 2015.

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Shih, Timothy K., Alan F. Smeaton, Halimah Badioze Zaman, et al. Advances in Visual Informatics: 5th International Visual Informatics Conference, IVIC 2017, Bangi, Malaysia, November 28–30, 2017, Proceedings. Springer, 2017.

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Chapitres de livres sur le sujet "IVIVC"

Malinowski, Henry J. "The Role of in Vitro-in Vivo Correlations (IVIVC) to Regulatory Agencies." In Advances in Experimental Medicine and Biology. Springer US, 1997. http://dx.doi.org/10.1007/978-1-4684-6036-0_24.

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Devane, John. "Impact of IVIVR on Product Development." In Advances in Experimental Medicine and Biology. Springer US, 1997. http://dx.doi.org/10.1007/978-1-4684-6036-0_23.

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Sathe, Pradeep, Yi Tsong, and Vinod P. Shah. "in Vitro Dissolution Profile Comparison and IVIVR." In Advances in Experimental Medicine and Biology. Springer US, 1997. http://dx.doi.org/10.1007/978-1-4684-6036-0_3.

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Dunne, Adrian, Tom O’Hara, and John Devane. "Approaches to IVIVR Modelling and Statistical Analysis." In Advances in Experimental Medicine and Biology. Springer US, 1997. http://dx.doi.org/10.1007/978-1-4684-6036-0_6.

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Balogh, Larissa M., and Yurong Lai. "Applications of Targeted Proteomics in ADME for IVIVE." In Transporters in Drug Development. Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-8229-1_5.

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Rostami-Hodjegan, Amin. "Translation of In Vitro Metabolic Data to Predict In Vivo Drug–Drug Interactions: IVIVE and Modeling and Simulations." In Enzyme- and Transporter-Based Drug-Drug Interactions. Springer New York, 2009. http://dx.doi.org/10.1007/978-1-4419-0840-7_13.

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"Study Design Considerations for IVIVC Studies." In Pharmaceutical Dissolution Testing. CRC Press, 2005. http://dx.doi.org/10.1201/9780849359170-13.

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Farrell, Colm, Myriam Rochdi, and Theresa Shepard. "Study Design Considerations for IVIVC Studies." In Pharmaceutical Dissolution Testing. Informa Healthcare, 2005. http://dx.doi.org/10.1201/9780849359170.ch10.

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Farrell, Colm, and Siobhan Hayes. "IVIVC for Oral Drug Delivery: Immediate Release and Extended Release Dosage Forms." In Pharmaceutical Product Development. CRC Press, 2007. http://dx.doi.org/10.3109/9781420020175-6.

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Sinha, Mansi. "In Vitro Dissolution and In Vitro-In Vivo Correlation." In Computer Aided Drug Development. THINKPLUS PHARMA PUBLICATIONS, 2024. http://dx.doi.org/10.69613/7q2gpa47.

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The integration of computational systems in dissolution testing and in vitro-in vivo correlation (IVIVC) has revolutionized pharmaceutical development and quality control processes. Advanced software platforms enable automated data collection, analysis, and interpretation of dissolution profiles while facilitating real-time monitoring of drug release kinetics. Machine learning applications enhance the accuracy of dissolution profile comparisons and improve the prediction of in vivo drug behavior based on in vitro data. Automated systems handle large datasets from multiple dissolution tests, pe

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Actes de conférences sur le sujet "IVIVC"

Hardy, James, Lu Liu, Nik Bessis, Lei Cui, and Jianxin Li. "Performance Measurements in iVIC Virtual Machine Clones." In 2012 IEEE Workshops of International Conference on Advanced Information Networking and Applications (WAINA). IEEE, 2012. http://dx.doi.org/10.1109/waina.2012.41.

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McFetridge, Bob, and Barry Stephens. "Can a grid be smart without communications? A look at IVVC implementation." In 2013 IEEE Rural Electric Power Conference (REPC). IEEE, 2013. http://dx.doi.org/10.1109/repcon.2013.6681847.

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Rapports d'organisations sur le sujet "IVIVC"

Committee on Toxicology. COT FSA PBPK for Regulators Workshop Report 2021. Food Standards Agency, 2024. http://dx.doi.org/10.46756/sci.fsa.tyy821.

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The future of food safety assessment in the UK depends on the Food Standards Agency’s (FSA) adaptability and flexibility in responding to and adopting the accelerating developments in science and technology. The Tox21 approach is an example of one recent advancement in the development of alternative toxicity testing approaches and computer modelling strategies for the evaluation of hazard and exposure (New Approach Methodologies (NAMs). A key aspect is the ability to link active concentrations in vitro to likely concentrations in vivo, for which physiologically based pharmacokinetic (PBPK) mod

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