Littérature scientifique sur le sujet « J/psi COMPASS »

Abstract We study integral operators $\mathcal{L}u\left( \chi \right)=\int{_{_{\mathbb{R}}\mathbb{N}}\psi \left( u\left( x \right)-u\left( y \right) \right)J\left( x-y \right)dy}$of the type of the fractional p-Laplacian operator, and the properties of the corresponding Orlicz and Sobolev-Orlicz spaces. In particular we show a Poincaré inequality and a Sobolev inequality, depending on the singularity at the origin of the kernel J considered, which may be very weak. Both inequalities lead to compact inclusions. We then use those properties to study the associated elliptic problem $\mathcal{L}u=f$in a bounded domain $\Omega ,$and boundary condition u ≡ 0 on ${{\Omega }^{c}};$both cases f = f(x) and f = f(u) are considred, including the generalized eigenvalue problem $f\left( u \right)=\lambda \psi \left( u \right).$

<abstract><p>This paper deals with a well known open problem raised by Kannan (Bull. Calcutta Math. Soc., 60: 71–76, 1968) and B. E. Rhoades (Contemp. Math., 72: 233–245, 1988) on the existence of general contractions which have fixed points, but do not force the continuity at the fixed point. We propose some new affirmative solutions to this question using two new contractions called $ (\psi, \varphi) $-$ \mathcal{A} $-contraction and $ (\psi, \varphi) $-$ \mathcal{A^{\prime}} $-contraction inspired by the results of H. Garai et al. (Applicable Analysis and Discrete Mathematics, 14(1): 33–54, 2020) and P. D. Proinov (J. Fixed Point Theory Appl. (2020) 22: 21). Some new fixed point and common fixed point results in compact metric spaces and also in complete metric spaces are proved in which the corresponding contractive mappings are not necessarily continuous at their fixed points. Moreover, we show that new solutions to characterize the completeness of metric spaces. Several examples are provided to verify the validity of our main results.</p></abstract>

Abstract Interior modeling of Jupiter and Saturn has advanced to a state where thousands of models are generated that cover the uncertainty space of many parameters. This approach demands a fast method of computing their gravity field and shape. Moreover, the Cassini mission at Saturn and the ongoing Juno mission delivered gravitational harmonics up to J 12. Here we report the expansion of the theory of figures, which is a fast method for gravity field and shape computation, to the seventh order (ToF7), which allows for computation of up to J 14. We apply three different codes to compare the accuracy using polytropic models. We apply ToF7 to Jupiter and Saturn interior models in conjunction with CMS-19 H/He equation of state. For Jupiter, we find that J 6 is best matched by a transition from an He-depleted to He-enriched envelope at 2–2.5 Mbar. However, the atmospheric metallicity reaches 1 × solar only if the adiabat is perturbed toward lower densities, or if the surface temperature is enhanced by ∼14 K from the Galileo value. Our Saturn models imply a largely homogeneous-in-Z envelope at 1.5–4 × solar atop a small core. Perturbing the adiabat yields metallicity profiles with extended, heavy-element-enriched deep interior (diffuse core) out to 0.4 R Sat, as for Jupiter. Classical models with compact, dilute, or no core are possible as long as the deep interior is enriched in heavy elements. Including a thermal wind fitted to the observed wind speeds, representative Jupiter and Saturn models are consistent with all observed J n values.

<abstract><p>In this paper, we prove the existence of the approximate $ (\sigma, \tau) $-Hermitian Yang-Mills structure on the $ (\sigma, \tau) $-semi-stable quiver bundle $ \mathcal{R} = (\mathcal{E}, \phi) $ over compact Gauduchon manifolds. An interesting aspect of this work is that the argument on the weakly $ L^{2}_1 $-subbundles is different from [Álvarez-Cónsul and García-Prada, Comm. Math. Phys., 2003] and [Hu-Huang, J. Geom. Anal., 2020].</p></abstract>

Fourier-transform i.r. spectroscopy, 1H-n.m.r. spectroscopy and X-ray scattering were used to study the conformation and shape of the peptide PKI(5-22)amide, which contains the active site of the inhibitor protein of the cyclic AMP-dependent protein kinase [Cheng, Van Pattern, Smith & Walsh (1985) Biochem. J. 231, 655-661]. The X-ray-scattering solution studies show that the peptide has a compact structure with Rg 0.9 nm (9.0 A) and a linear maximum dimension of 2.5 nm (25A). Compatible with this, Fourier-transform i.r. and n.m.r. determinations indicate that the peptide contains approx. 26% alpha-helix located in the N-terminal one-third of the molecule. This region contains the phenylalanine residue that is one essential recognition determinant for high-affinity binding to the protein kinase catalytic site.

Abstract An inverse problem of identifying an unknown shear force {g(t)} on the inaccessible boundary {x=l} in a system governed by the general form Euler–Bernoulli beam equation \rho(x)u_{tt}+\mu(x)u_{t}+(r(x)u_{xx})_{xx}=0,\quad(x,t)\in(0,l)\times(0,T) subject to the boundary conditions u(0,t)=u_{x}(0,t)=0,\quad u_{xx}(l,t)|_{x=l}=0,\quad-(r(x)u_{xx}(x,t))_{x}|_{x% =l}=g(t), is studied. The bending moment {\mathtt{M}(t)\coloneq-r(0)u_{xx}(0,t)} given at the accessible boundary {x=0} is assumed to be a measured output. The Neumann-to-Neumann operator \Phi[\,{\cdot}\,]\colon\mathcal{G}\subset H^{p}(0,l)\mapsto L^{2}(0,T),\quad(% \Phi g)(t)\coloneq-r(0)u_{xx}(0,t_{g}) corresponding to this inverse problem is shown to be compact ( {p=3} ) and Lipschitz continuous ( {p=2} ). These properties allow us to prove the existence of a solution of the minimization problem for the Tikhonov functional {J(g)\coloneq\lVert\Phi g-\mathtt{M}\rVert^{2}_{L^{2}(0,T)}} . It is proved that this functional is Fréchet differentiable. Furthermore, an explicit formula for the Fréchet gradient of this functional is derived by making use of the unique solution to corresponding adjoint problem. A numerical method based on Hermitian finite elements and conjugate gradient algorithm is developed for the solution of the inverse boundary value problem. Numerical examples with random noisy measured outputs are presented to illustrate the validity and effectiveness of the proposed approach.

The genus Antodice Thomson, 1864 was revised by Martins & Galileo (1998) and currently includes 27 species (Tavakilian & Chevillotte 2017), distributed from Mexico to southern South America. Based on a single female specimen collected in Arroyo Cristal, Ka'azapá, Paraguay, the species Antodice quadrimaculata was first described by Martins & Galileo in 2003. The holotype specimen was collected on 20 November 1999 by J. Jensen and is deposited in the Museum of Zoology of the University of São Paulo, Brazil. With the help of Carlos Aguilar, from Paraguay’s National Museum of Natural History, we were able to determine the exact location where the holotype was collected. With the collection and the description of the male, presented herein, we describe the male of this species record its occurrence in Brazil, a new country record.We identified this species as belonging to the group of Antodice species with yellowish flagellomeres and a black apex, resembling Antodice venustula Lane, 1973 in its elytral color pattern. In A. venustula, the elytra are covered with whitish pubescence and exhibit only two patches of compact white pubescence. In A. quadrimaculata, according to Martins & Galileo (2003), the elytra are of a reddish color with whitish pubescence on the dorsal anterior area and close to the apexes, and they also have three patches of compact white pubescence. The specimens of A. quadrimaculata cited herein were collected in the Iguaçu National Park (Parque Nacional do Iguaçu—PNI), the largest fragment of Atlantic forest in southern Brazil, located in the western region of the state of Paraná. The insects were collected using light traps, set up on nights with a new moon. The artificial light source was a 500-Watt incandescent lamp powered by a Honda EP 2500 generator. Sampling began at 6 p.m., ending between midnight and 3 a.m. the next day. The studied material was deposited in the entomological collection of the Museum of Zoology at the State University of Londrina (Universidade Estadual de Londrina), Londrina, Brazil (MZUEL). To better represent the expansion of the geographical distribution of the species from the holotype recorded in Paraguay (Fig. 5, 6), the cartographic material (Fig. 1) was produced using ArcGIS Software 9.0®. The map database was obtained from the Institute of Land, Cartography and Geosciences, (Instituto de Terras, Cartografia e Geologia do Paraná), Curitiba, Brazil (ITCG).

Abstract Background: T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is an inhibitory immune checkpoint receptor expressed on subsets of T cells and NK cells. In multiple myeloma (MM), TIGIT expression increases as the disease progresses and correlates with defective T cell effector functions. Higher TIGIT expression was observed in MM bone marrow CD8+ T cells in mice and patients compared to other immune checkpoint inhibitors, including PD-1, TIM-3, LAG-3, or CTLA-4 (Guillerey, C. et al, Blood 2018; Minnie, S. A. et al . Blood 2018). EOS884448/GSK4428859A (EOS-448) is a potent and highly selective fully human antagonist IgG1 antibody targeting TIGIT. Preclinically, anti-TIGIT Ab elicits superior anti-tumor immune responses compared to anti-PD1 mAbs (Guillerey, C. et al, Blood 2018). In murine Vk*Myc MM models, Fc-enabled a-TIGIT Ab elicits effective control of MM disease progression after autologous stem-cell transplant (ASCT), while Fc-disabled version is inactive. Anti-tumor activity is seen with monotherapy after ASCT at high T cell doses and provides significant synergistic activity when combined with an Immunomodulatory imide drug (IMiD) if T cell doses are suboptimal (Minnie, S. A. et al, Abstract submitted ASH 2021). Iberdomide (also known as CC-220) is a novel potent cereblon (CRBN) E3 ligase modulatory compound (CELMoD) that regulates multiple transcription factors within immune cells (Gandhi, A. K. et al . Brit J Haematol 2014). Iberdomide has shown notable clinical activity and acceptable tolerability in heavily pre-treated patients with relapsed or refractory multiple myeloma (RRMM), including those refractory to prior IMiDs (Lonial, S. et al. J Clin Oncol 2019). Given the dominant role of TIGIT in the immune suppression associated with MM, we hypothesize that TIGIT represents an ideal checkpoint to target clinically. EOS-448 alone or the synergistic combination of EOS-448 with iberdomide may provide a therapeutic opportunity to amplify myeloma-specific T-cell anti-tumor responses in difficult to treat RRMM patients previously exposed to IMiD, proteasome inhibitors (PIs) and anti-CD38. Methods: This phase I/II, open-label, multicenter, dose-escalation/expansion study will assess the safety, tolerability and preliminary activity of EOS-448 as monotherapy and in combination with iberdomide with or without dexamethasone in up to 158 adults with RRMM, who have progressed after prior treatments with IMiDs, PI and anti-CD38. EOS-448 will be infused intravenously on Day 1 of 28-day cycles. In Part 1, the safety and tolerability of EOS-448 as monotherapy and in combination with iberdomide with or without dexamethasone will be assessed in cohorts of up to 18 participants to identify the maximum tolerated dose and recommended phase II dose (RP2D) in each of the 3 treatment arms. In Part 2, the safety and anti-cancer activity of the RP2D will be assessed in up to 102 RRMM participants. Primary endpoints are treatment emergent adverse events, laboratory abnormalities, dose-limiting toxicities and clinical activity according to the International Myeloma Working Group (IMWG) Uniform Response Criteria. Secondary endpoints include overall response rates, duration of response, PK, and antidrug antibodies. Exploratory biomarkers including study treatment-mediated pharmacodynamic (PD) effects, PK-PD correlations, and correlative analyses of predictive and PD measurements with response, toxicity, and resistance will be investigated. Minimal residual disease (MRD) status with therapy will also be assessed as clinically indicated. The study is planned to open in November 2021 in North America and Europe. Disclosures Moreau: Abbvie: Honoraria; Amgen: Honoraria; Janssen: Honoraria; Sanofi: Honoraria; Celgene BMS: Honoraria; Oncopeptides: Honoraria. Holmberg: Janssen: Research Funding; Merck: Research Funding; Seattle Genetics: Research Funding; Sanofi: Research Funding; Millennium-Takeda: Research Funding; Bristol Myers Squibb: Research Funding; Up-To-Date: Patents & Royalties. Meuleman: iTeos Therapeutics: Consultancy. Graham: iTeos Therapeutics: Current Employment. De Henau: iTeos Therapeutics: Current Employment, Current equity holder in publicly-traded company; Bristol-Meyer-Squibb: Current equity holder in publicly-traded company. Driessens: iTeos Therapeutics: Current Employment, Current equity holder in publicly-traded company. McGrath: iTeos Therapeutics: Current Employment, Current equity holder in publicly-traded company; Norgine: Other: Spouse Current Employment. Lager: iTeos Therapeutics: Current Employment, Current equity holder in publicly-traded company. Hill: NeoLeukin Therapeutics: Consultancy; Applied Molecular Transport: Research Funding; Syndax Pharmaceuticals: Research Funding; NapaJen Pharma: Consultancy; iTeos Therapeutics: Consultancy, Research Funding; Compass Therapeutics: Research Funding; Generon Corporation: Consultancy; Roche: Research Funding.

AbstractRecently the LHCb Collaboration announced the first observation of nontrivial structures in the double-$$J/\psi $$ J / ψ mass spectrum in the mass range 6.2–7.2 GeV, and a theoretical coupled-channel analysis of these data performed in Dong et al. (Phys Rev Lett 126:132001, 2021) evidenced the existence of a new state X(6200) close to the double-$$J/\psi $$ J / ψ threshold. Although its molecular interpretation seems the most plausible assumption, the present data do not exclude an admixture of a compact component in its wave function, for which a fully-charmed compact tetraquark is the most natural candidate. It is argued in this work that the QCD string model is compatible with the existence of a compact $$cc{\bar{c}}{\bar{c}}$$ c c c ¯ c ¯ state bound by QCD forces just below the double-$$J/\psi $$ J / ψ threshold. A nontrivial interplay of the quark dynamics associated with this compact state and the molecular dynamics provided by soft gluon exchanges between $$J/\psi $$ J / ψ mesons is discussed and the physical X(6200) is argued to be a shallow bound state, in agreement with the results of the aforementioned coupled-channel analysis of the LHCb data.

Jointly-supervised doctoral thesis Title: Nucleon spin structure studies in Drell-Yan process at COMPASS Author: Jan Matoušek Department I: Department of Low Temperature Physics, Faculty of Mathem- atics and Physics, Charles University Department II: Department of Physics, University of Trieste Supervisor I: prof. Miroslav Finger (Department I) Supervisor II: prof. Anna Martin (Department II) Abstract: The nucleon structure is presently described by Transverse Momentum Depend- ent (TMD) Parton Distribution Functions (PDFs), which generalise the collinear PDFs, adding partonic spin and transverse momentum degrees of freedom. The recent HERMES and COMPASS data on hadron production in deep inelastic scattering (SIDIS) of leptons off transversely polarised nucleons have provided a decisive validation of this framework. Nevertheless, the TMD PDFs should be studied in complementary reactions, like pp hard scattering and Drell-Yan pro- cesses. In particular the Sivers TMD PDF, which encodes the correlation between the nucleon transverse spin and quark transverse momentum and appears in the Sivers Transverse Spin Asymmetry (TSA), is expected to have opposite sign in Drell-Yan and SIDIS. In 2015 COMPASS measured for the first time the Drell- Yan process on a transversely polarised target π− p↑ → µ− µ+ X to test...

In this work we present the basic theoretical concepts of the description of the nucleon spin structure. The theoretical background of two processes of interest - Semi-inclusive DIS and Drell-Yan - in the terms of Transverse Momentum De- pendent Parton distribution Functions is presented. The COMPASS experiment and particularly its unique polarised target are described in detail. Several target related measurements are presented. The express analysis and detector efficien- cies analysis are presented as examples of important hardware related analysis. Finally two measurements of Transverse Spin Asymmetries are presented. The first measurement is the measurement of the Transverse Spin Asymmetries in J/ψ production in the Semi-inclusive DIS on polarised protons. The second mea- surement is the measurement of Transverse Spin Asymmetries in J/ψ in the π− p polarised Drell-Yan data. 1

Design guidance for high pressure components, has undergone a dramatic change with the release of ASME Section VIII division 3 pressure vessel code. For the first time, a thorough design criteria is available for design of thick wall pressure vessels. The most critical components of a design are safety and reliability. Ultra high-pressure vessels, in most cases, do not have an “infinite” life. The design must therefore be “leak before break” and a design cycle life must be specified. This paper looks at the effects of fatigue on commercial high-pressure tubing under tri-axial fatigue. The tubing investigated is 316 stainless steel 9/16″ and 3/8″ diameter 4100 bar (60,000 psi) tubing. The testing was performed using a tri-axial fatigue machine originally designed by Dr. B. Crossland, Dr. J. L. M. Morrison and Dr. J. S. C. Perry in 1960 and upgraded by the Author. This investigation compares the fatigue life prediction per KD3 in the ASME pressure vessel code Section VIII division 3 and actual test results from the fatigue machine. This verification gives important reliability data for commercial hardware used in high-pressure piping.