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Articles de revues sur le sujet « Kd 3310 »

Auteur : Grafiati

Publié le 25 juillet 2024

Mis à jour le 31 juillet 2025

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1

Liu, Guocong. "Chemical compositions, A-glucosidase and A-amylase inhibitory activities of crude polysaccharides from the endodermis of shaddock (Citrus maxima)." Archives of Biological Sciences 64, no. 1 (2012): 71–76. http://dx.doi.org/10.2298/abs1201071l.

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The chemical composition of shaddock mainly includes polyphenols, proteins and polysaccharides. However, polysaccharides from shaddock materials have received much less consideration than polyphenols (Fellers et al., 1990). Herein the chemical compositions, ?-glucosidase and ?-amylase inhibitory activities of crude polysaccharides from the endodermis of shaddock were investigated. The exopolysaccharides (EPS) exhibited a broad and intense peak at 3300-3400 cm-1 that characterized the absorption of the hydroxyl group, and one weak C-H band at around 2941.3 cm-1 in the IR spectrum. The content o

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Savko, K. A., A. V. Samsonov, and A. N. Larionov. "Mesoarchean silicic volcanics of the Kursk block, Voronezh crystalline massif: composition, age and correlation with the Ukrainian shield." Доклады Академии наук 486, no. 6 (2019): 718–22. http://dx.doi.org/10.31857/s0869-56524866718-722.

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Rhyolites and basite rocks are present in the Archaean greenstone belts of the Kursk Domain (KD) of the East Sarmatia. The rhyolite age is 3122 ± 9 Ma (zircons, SIMS). A positive εNd (3122) = + 0.9 for rhyolites and their Sm-Nd model age ТNd (DM) = 3300 Ma as well as the age of the inherited zircon (3250 Ma) testifies to the participation of the more ancient crust component in the formation of rhyolite magmas. In geochemistry, rhyolites are very close to the TTG of the KD with an age 2.96-3.03 Ga. In the Middle Dnieper granite - greenstone area there are rhyolites and dacites with an age of 3.

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Setiawan, Budi, Yusran Dani, and Nurmaya Arofah. "Sorption Characteristics of ¹³⁷Cs and ⁹⁰Sr into Rembang and Sumedang Soils." Indonesian Journal of Chemistry 16, no. 3 (2018): 277. http://dx.doi.org/10.22146/ijc.21142.

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In order to understand the sorption behavior of 137Cs and 90Sr into soil sample from Rembang and Subang, it is important to estimate the effect of contact time, ionic strength and concentration of metal ion in the solution. For this reason, the interaction of 137Cs and 90Sr with soil sample has been examined. The study performed at trace concentration (~10-8 M) of CsCl and SrCl2, and batch method was used. NaCl has been selected as a representative of the ionic strength with 0.1; 0.5 and 1.0 M concentrations. Concentration of 10-8~10-4 M CsCl and SrCl2 were used for study the effect of Cs and

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Wikström, L., and H. F. Lodish. "Nonlysosomal, pre-Golgi degradation of unassembled asialoglycoprotein receptor subunits: a TLCK- and TPCK-sensitive cleavage within the ER." Journal of Cell Biology 113, no. 5 (1991): 997–1007. http://dx.doi.org/10.1083/jcb.113.5.997.

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The human asialoglycoprotein receptor subunit H2a is cotranslationally inserted into the ER membrane. When expressed together with subunit H1 in mouse fibroblasts part forms a hetero-oligomer that is transported to the cell surface, but when expressed alone it is all rapidly degraded. Degradation is insensitive to lysosomotropic agents and the undegraded precursor is last detected in the ER region of the cell. Small amounts of an intermediate 35-kD degradation product can be detected (Amara, J. F., G. Lederkremer, and H. F. Lodish. 1989. J. Cell Biol. 109:3315). We show here that the oligosacc

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Gong, Xueqian, Hong Gao, Mark H. Bender, et al. "Abstract 3316: LY3962673, an oral, highly potent, mutant-selective, and non-covalent KRAS G12D inhibitor demonstrates robust anti-tumor activity in KRAS G12D models." Cancer Research 84, no. 6_Supplement (2024): 3316. http://dx.doi.org/10.1158/1538-7445.am2024-3316.

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Abstract KRAS G12D mutations are activating oncogenic events that occur in approximately 35%, 13%, and 4% of pancreatic, colorectal, and non-small cell lung cancers, respectively, and less commonly in other cancers. We previously demonstrated that LY3962673 is a highly potent inhibitor of KRAS G12D and is selective against wild-type (WT) KRAS in mutant -cell lines and -in vivo models. Here, we describe the mechanism by which LY3962673 inhibits KRAS G12D and report a more comprehensive evaluation of LY3962673 activity across a panel of genetically and histologically diverse cancer cell lines, a

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Martin, Thomas, Joseph Mikhael, Roman Hajek, et al. "Depth of Response and Response Kinetics of Isatuximab Plus Carfilzomib and Dexamethasone in Relapsed Multiple Myeloma: Ikema Interim Analysis." Blood 136, Supplement 1 (2020): 7–8. http://dx.doi.org/10.1182/blood-2020-137681.

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Introduction: Achievement of minimal residual disease negative (MRD-) status in multiple myeloma (MM) is associated with improved progression-free survival (PFS) and overall survival (OS). Isatuximab (Isa) is an approved anti-CD38 IgG kappa monoclonal antibody. We analyzed the depth of response including MRD-, long-term outcomes, and kinetics of tumor response in the IKEMA study. Measurement by mass spectrometry of serum M-protein was also performed to overcome the interference with Isa in standard immunofixation assay. Methods: IKEMA was a randomized, open-label, multicenter Phase 3 study tha

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Rodriguez, Cesar, Aurore Perrot, Paul G. Richardson, et al. "The Impact of Isatuximab Regimens on Hypogammaglobulinemia Occurrence, Recovery, and Associated Infections in Patients with Relapsed/Refractory Multiple Myeloma." Blood 142, Supplement 1 (2023): 1980. http://dx.doi.org/10.1182/blood-2023-179925.

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Introduction: Isatuximab (Isa) is an immunoglobulin (Ig)G1 monoclonal antibody targeting a CD38 transmembrane glycoprotein in multiple myeloma (MM). Isa is approved for use in multiple countries to treat adults with relapsed/refractory MM (RRMM) when given in combination with either pomalidomide-dexamethasone (Pd) or carfilzomib-dexamethasone (Kd). Hypogammaglobulinemia (HGG; polyclonal IgG &lt;4 g/L) and the associated infection risk is a potential complication for patients (pts) with MM treated with immunotherapies. High infection and HGG rates have been reported during treatment (tx) wi

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BECKINGHAM, Jennifer A., Nicholas G. HOUSDEN, Nicola M. MUIR, Stephen P. BOTTOMLEY, and Michael G. GORE. "Studies on a single immunoglobulin-binding domain of protein L from Peptostreptococcus magnus: the role of tyrosine-53 in the reaction with human IgG." Biochemical Journal 353, no. 2 (2001): 395–401. http://dx.doi.org/10.1042/bj3530395.

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Chemical modification experiments with tetranitromethane (TNM) have been used to investigate the role of tyrosine residues in the formation of the complex between PpL (the single Ig-binding domain of protein L, isolated from P. magnus strain 3316) and the kappa light chain (κ-chain). Reaction of PpL with TNM causes the modification of 1.9 equiv. of tyrosine (Tyr51 and Tyr53) and results in an approx. 140-fold decrease in affinity for human IgG. Similar experiments with mutated PpL proteins suggest that nitration predominantly inactivates the protein by modification of Tyr53. Reduction of the n

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Shang, Erchang, Boyu Zhong, Tony Zhang, et al. "Abstract 3315: Preclinical studies of TSN1611, a potent, selective, and orally bioavailable KRASG12D inhibitor." Cancer Research 84, no. 6_Supplement (2024): 3315. http://dx.doi.org/10.1158/1538-7445.am2024-3315.

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Abstract Background: KRAS mutations are the most frequently encountered driver oncogene, involved in ~25% of all human cancers [1,2]. KRASG12D is the predominant KRAS mutation isoform, detected in approximately 35% of pancreatic cancer, 13% of colorectal cancer, and 5% of NSCLC [3]. Compared to KRASG12C, targeting KRASG12D has proven to be more challenging since the target protein lacks a reactive amino acid residue for irreversible inhibitory modification by a ligand. Herein, we disclose TSN1611, a potent and selective KRASG12D inhibitor, which possesses favorable oral PK profiles and demonst

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Trieu, V. N., and W. J. McConathy. "The binding of animal low-density lipoproteins to human apolipoprotein(a)." Biochemical Journal 309, no. 3 (1995): 899–904. http://dx.doi.org/10.1042/bj3090899.

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Lipoprotein(a) [Lp(a)] is a risk factor for coronary artery disease. It is composed of lipids and apolipoprotein(a) [apo(a)] linked to apolipoprotein B (apoB) by a disulphide bond between Cys-4057 of apo(a)'s kringle 36 and possibly Cys-3734 of apoB. We call this the covalent apo(a): apoB-Lp interaction, to distinguish it from the non-covalent apo(a)/Lp(a): apoB-Lp interaction, which is probably mediated by apo(a)'s kringle 33 and residues 3304-3317 of apoB. The non-covalent interaction could be the initial interaction which brings apo(a) and apoB together prior to covalent linkage and Lp(a) f

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Prado, Lucas G., Irina Makarenko, Christian Andresen, Martina Krüger, Christiane A. Opitz, and Wolfgang A. Linke. "Isoform Diversity of Giant Proteins in Relation to Passive and Active Contractile Properties of Rabbit Skeletal Muscles." Journal of General Physiology 126, no. 5 (2005): 461–80. http://dx.doi.org/10.1085/jgp.200509364.

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The active and passive contractile performance of skeletal muscle fibers largely depends on the myosin heavy chain (MHC) isoform and the stiffness of the titin spring, respectively. Open questions concern the relationship between titin-based stiffness and active contractile parameters, and titin's importance for total passive muscle stiffness. Here, a large set of adult rabbit muscles (n = 37) was studied for titin size diversity, passive mechanical properties, and possible correlations with the fiber/MHC composition. Titin isoform analyses showed sizes between ∼3300 and 3700 kD; 31 muscles co

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Long, Xin, Laszlo Perlaky, Tsz-Kwong Chris Man, and Michele S. Redell. "Stromal CYR61 Confers Resistance to Mitoxantrone Via Spleen Tyrosine Kinase Activation in Human Acute Myeloid Leukemia." Blood 124, no. 21 (2014): 2228. http://dx.doi.org/10.1182/blood.v124.21.2228.2228.

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Abstract Acute myeloid leukemia (AML) is a life-threatening bone marrow malignancy with a relapse rate near 50% in children, despite aggressive chemotherapy. Accumulating evidence shows that the bone marrow stromal environment protects a subset of leukemia cells and allows them to survive chemotherapy, eventually leading to recurrence. The factors that contribute to stroma-induced chemotherapy resistance are largely undetermined in AML. Our goal is to delineate the mechanisms underlying stroma-mediated chemotherapy resistance in human AML cells. We used two human bone marrow stromal cell lines

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Reddy, Pavankumar N. G., Jenna Wood, Chad E. Harris та ін. "Kinase Activity Of Pak2, An Effector Of Rac/CDC42 and Its Interaction With β-PIX Is Required For Murine Hematopoietic Stem Cell Shape, F-Actin Formation, Directional Migration In Vitro and For HSPC Homing To Bone Marrow In Vivo". Blood 122, № 21 (2013): 2419. http://dx.doi.org/10.1182/blood.v122.21.2419.2419.

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Abstract Hematopoietic stem and progenitor cell (HSPC) migration, marrow homing and engraftment are key physiological processes regulating hematopoiesis post transplantation. These processes are the result of the orchestrated actions of multiple extracellular stimuli, which regulate actin remodeling, cell polarity, chemotaxis and cell-cell interactions. In HSPC, the Rho GTPases Rac and CDC42 act as molecular switches that integrate extracellular stimuli in a spatially regulated manner to control cell migration and mediate homing to marrow and mobilization as well as cell survival/ proliferatio

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Halbert, Brian, David Einstein, David McDermott, et al. "176 Successful generation of tumor-infiltrating lymphocyte (TIL) product from renal cell carcinoma (RCC) tumors for adoptive cell therapy." Journal for ImmunoTherapy of Cancer 9, Suppl 2 (2021): A188. http://dx.doi.org/10.1136/jitc-2021-sitc2021.176.

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BackgroundPatients with RCC may achieve remission with immune-checkpoint inhibitors (ICI); however, most patients will progress. Adoptive cell therapy with autologous TIL allows for expansion of T-cells from tumor tissue leading to a polyclonal T-cell product with a diverse T-cell receptor repertoire capable of recognizing an array of tumor antigens. TIL therapy with centrally manufactured lifileucel demonstrated a 36% overall response rate in patients with ICI-refractory melanoma.1 We present our preclinical experience of TIL production in RCC.MethodsThis study was approved by the DF/HCC Inst

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Watanabe, Keisuke, Seitaro Terakura, Susumu Uchiyama, et al. "Excessively High-Affinity Single-Chain Fragment Variable Region in a Chimeric Antigen Receptor Can Counteract T-Cell Proliferation." Blood 124, no. 21 (2014): 4799. http://dx.doi.org/10.1182/blood.v124.21.4799.4799.

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Abstract Background: Single-chain fragment variable region (scFv) in a chimeric antigen receptor (CAR) is a key component that directly binds the target antigen and transmits an activating signal into the CAR-T cells, subsequently triggering its effector function against the target cell. Thus, the affinity of scFv is considered to be critically important for CAR-T-cell function. However, optimal scFv affinity to induce maximal CAR function remains unclear. Methods: In this study, we constructed anti-CD20 scFv based on the reported sequence of humanized anti-CD20 monoclonal antibody with five d

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Yang, Jinrong, Zixu Wang, Kun Wu, et al. "Isocitrate dehydrogenase 2 mutation promotes cytarabine resistance in acute myeloid leukemia by Warburg effect." Hematological Oncology 42, no. 6 (2024). http://dx.doi.org/10.1002/hon.3316.

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AbstractMutation of isocitrate dehydrogenase 2 (IDH2) is a key factor in promoting cytarabine (Ara‐C) resistance in acute myeloid leukemia (AML), however the underly mechanism remains unclear. Acute myeloid leukemia cells, were cultured with either IDH2 knockdown (KD‐IDH2) or overexpression (OE‐IDH2) to elucidate the role of IDH2 in these leukemic cell lines. Additionally, mutant cell lines were engineered to replicate clinically relevant IDH2 mutations. To investigate cellular responses, the glycolytic inhibitor 2‐deoxy‐D‐glucose (2‐DG) was administered to the cells. Cell proliferation was qu

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Shihab, Ramzi. "RETENTION CAPACITY OF SOME IRAQI SOILS FOR CESIUM-137 (CS137) RADIONUCLIDES AND ITS RELATION WITH LEACHING SOLUTION." Iraqi Journal of Desert Studies, December 26, 2000, 1–10. http://dx.doi.org/10.36531/ijds/20100201.

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Cesium-137 has been worldwide used for estimation soil erosion. Its movement and transport in the environmental media depend on its retention by soil. Retention capacity of soil for radionuclides and pollutants as expressed by the distribution coefficient Kd (ratio of radionuclides retained by soil to those remained in liquid) that was estimated for 137Cs in some soils of Iraq. The soils were varied in clay 24.0-50.5%, organic mater 0.5-1.5%, and lime content 28.1-35.0%. Results showed that all the factors investigated were found to alter the values of Kd. The mean of Kd was 774 L kg-1 in the

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Yan, Yu, Lina Qiao, Yimin Hua, et al. "Predictive value of Albumin-Bilirubin grade for intravenous immunoglobulin resistance in a large cohort of patients with Kawasaki disease: a prospective study." Pediatric Rheumatology 19, no. 1 (2021). http://dx.doi.org/10.1186/s12969-021-00638-7.

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Abstract Background Intravenous immunoglobulin (IVIG) resistance prediction is one of the primary clinical issues and study hotspots in KD. This study aimed to prospectively investigate the value of albumin-bilirubin grade (ALBI) in predicting IVIG resistance in KD and to assess whether ALBI has more predictive value or accuracy than either ALB or TBil alone in predicting IVIG resistance. Methods A total of 823 patients with KD were prospectively enrolled. The clinical and laboratory data were compared between the IVIG-response group (n = 708) and the IVIG-resistance group (n = 115). Multivari

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Yoshikane, Yukako, Ryuji Fukazawa, Kyoko Imanaka-yoshida, Naho Kobayashi, and Yasuhiro Katsube. "Abstract 14551: Biomarkers Predicting the Treatment-Resistant Kawasaki Disease." Circulation 142, Suppl_3 (2020). http://dx.doi.org/10.1161/circ.142.suppl_3.14551.

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Introduction: Kawasaki disease (KD), which is the most common multisystem vasculitis with unknown causes in childhood, causes coronary artery lesions (CALs). Treatment with a high dose of intravenous immunoglobulin (IVIG), plus steroids if needed, is the most effective therapy for the acute phase of KD. However, there are some very severe cases who need several times additional treatments and are at risk for CALs. In Japan, there are some scoring systems that initially predict IVIG-resistant patients. However, the problem is that these scoring systems fail in multiethnic populations. The aim o

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Kim, Pora, Hanyang Li, Junmei Wang, and Zhongming Zhao. "Landscape of drug-resistance mutations in kinase regulatory hotspots." Briefings in Bioinformatics, June 8, 2020. http://dx.doi.org/10.1093/bib/bbaa108.

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Abstract More than 48 kinase inhibitors (KIs) have been approved by Food and Drug Administration. However, drug-resistance (DR) eventually occurs, and secondary mutations have been found in the previously targeted primary-mutated cancer cells. Cancer and drug research communities recognize the importance of the kinase domain (KD) mutations for kinasopathies. So far, a systematic investigation of kinase mutations on DR hotspots has not been done yet. In this study, we systematically investigated four types of representative mutation hotspots (gatekeeper, G-loop, αC-helix and A-loop) associated

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Lisova, Alisa E., Andrey G. Baranovskiy, Lucia M. Morstadt, Nigar D. Babayeva та Tahir H. Tahirov. "Efficient discrimination against RNA-containing primers by human DNA polymerase ε". Scientific Reports 12, № 1 (2022). http://dx.doi.org/10.1038/s41598-022-14602-2.

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AbstractDNA polymerase ε (Polε) performs bulk synthesis of DNA on the leading strand during genome replication. Polε binds two substrates, a template:primer and dNTP, and catalyzes a covalent attachment of dNMP to the 3' end of the primer. Previous studies have shown that Polε easily inserts and extends ribonucleotides, which may promote mutagenesis and genome instability. In this work, we analyzed the mechanisms of discrimination against RNA-containing primers by human Polε (hPolε), performing binding and kinetic studies at near-physiological salt concentration. Pre-steady-state kinetic studi

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Thakur, Mathew, Leonard G. Gomella, Vivek Singh, et al. "A non-DRE, voided urine, genomic assay to diagnose prostate cancer and to assess its aggressiveness." Journal of Clinical Oncology 43, no. 16_suppl (2025). https://doi.org/10.1200/jco.2025.43.16_suppl.e17145.

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e17145 Background: The standard clinical practice to diagnose the presence and aggressiveness of prostate cancer, (PCa) consists of measuring serum prostate specific antigen (PSA), and performing image guided biopsies for histopathology. Due to the invasive nature potential risks and costs associated with prostate biopsy, urine based assays have been developed that require digital rectal examination (DRE) and to ascertain certain biomarkers present in the urine. These assays are not commonly integrated into clinical practice due to low sensitivity and high cost. Our goal was to develop a simpl

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