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Thèses sur le sujet « KDMs »

Auteur : Grafiati

Publié le 10 mars 2023

Mis à jour le 31 juillet 2025

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1

Balzano, Amodio Luca. "Design, synthesis, biological evaluation and binding studies of new small-molecule modulators of KDMs (lysine-specific demethylases)." Doctoral thesis, Universita degli studi di Salerno, 2017. http://hdl.handle.net/10556/2419.

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2014 - 2015<br>JHDMs (JmjC-domain-containing histone demethylases) are the largest class of demethylase enzymes, contain a Jumonji C (JmjC) domain and catalyze lysine demethylation of histones through an oxidative reaction that requires Fe(II) ion and α-ketoglutarate (2OG) as cofactors. The misregulation of these enzymes, in particular JMJD2 subfamily, has being significantly implicated in cancer initiation and progression. Potent and specific inhibitors of these enzymes have not been identified yet, most of them inhibiting many other Fe(II)/2OG dependent oxygenases or being affected by undesi

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Schiller, Rachel Shamo. "Investigating the inhibitor and substrate diversity of the JmjC histone demethylases." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:1e7fd2a1-a9c3-48f7-8fa7-a041299d42f9.

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Epigenetic control of gene expression by histone post-translational modifications (PTMs) is a complex process regulated by proteins that can 'read', 'write' or 'erase' these PTMs. The histone lysine demethylase (KDM) family of epigenetic enzymes remove methyl modifications from lysines on histone tails. The Jumonji C domain (JmjC) family is the largest family of KDMs. Investigating the scope and mechanisms of the JmjC KDMs is of interest for understanding the diverse functions of the JmjC KDMs in vivo, as well as for the application of the basic science to medicinal chemistry design. The work

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Hookway, Edward. "The role of the lysine demethylases KDM5 and KDM6 in bone malignancies." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:b591861f-985b-4722-8027-492e750f3ff7.

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Methylation of histone lysine residues functions as a dynamic, reversible mechanism for regulating gene expression and aberrations in this process have been linked with the development of cancer. Members of the lysine demethylase (KDM) family remove methyl marks from histones. KDM5B removes methyl marks from histone H3 lysine 4 (H3K4) whereas KDM6A and KDM6B remove methyl marks from histone H3 lysine 27 (H3K27). In this thesis, GSK-J4, an inhibitor of KDM5B, KDM6A and KDM6B, is shown to impair viability in a range of cancers affecting bone including multiple myeloma, Ewing sarcoma and chordoma

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Chen, Runqiu, and 陳潤球. "Statistical validation of kidney deficiency syndromes (KDS) and the development of a KDS questionnaire in Hong Kong Chinese women aged 40-60 years." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43223813.

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Chen, Runqiu. "Statistical validation of kidney deficiency syndromes (KDS) and the development of a KDS questionnaire in Hong Kong Chinese women aged 40-60 years." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B43223813.

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Ådahl, Hanna, and My Brännström. "The naked truth? : En kritisk diskursanalys om fast fashion-företaget NA-KD:s externa kommunikation." Thesis, Umeå universitet, Institutionen för kultur- och medievetenskaper, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-179312.

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The purpose of this study was to increase the understanding of how the Swedish fast fashion company NA-KD expressed its profile and how it could be linked to sustainability. The fashion industry is known for having big sustainability problems, and that is why the main focus of this study was the paradox between fast fashion and sustainability due to its conflict nature. To concretise the aim of the study, we formulated two questions: “What discourses can be found in NA-KD’s external communication?” and “What profile does the company express through their website?”. To analyse the company’s web

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Khin, Khin Nyo Aree Jampaklay. "Access to health utilization among people aged 50 and older in KDSS is it equal /." Abstract, 2007. http://mulinet3.li.mahidol.ac.th/thesis/2550/cd404/4938533.pdf.

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Autaa, Julie. "The role of the histone demethylase Kdm3 complex in defining the boundaries of piRNA clusters." Electronic Thesis or Diss., Sorbonne université, 2024. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2024SORUS234.pdf.

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Pour préserver l'intégrité du génome de la lignée germinale animale, l'activité des éléments transposables (TE) est régulée par de petits ARN non codants appelés ARN piwi-interacting (piRNAs). Dans les ovaires de Drosophila melanogaster, les piRNAs proviennent de régions hétérochromatiques appelées piRNA clusters. Ces régions présentent un enrichissement en séquences incomplètes de TE et des marques de di- ou tri-méthylation de la lysine 9 sur l'histone 3 (H3K9me2/3), caractéristiques de l'hétérochromatine. Malgré une chromatine condensée, la transcription se produit dans ces régions, facilité

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Bader, Caroline, Eva-Louise Castefelt, and Louise Gunnarsson. "Influencers Marketing : En fallstudie om NA-KDs nyckel till en god tillväxt." Thesis, Högskolan i Borås, Akademin för textil, teknik och ekonomi, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-15381.

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Begreppet influencer blir mer och mer välkänt för varje dag. Begreppet syftar till ett yrke som vuxit fram i takt med internet. Även om det finns mycket information att tillgå kring fenomenet finns det många aspekter som fortfarande icke blivit belysta. Den information som finns att tillgå kring ämnet är inte heller i vetenskaplig tappning. Syftet med studien är att analysera och redogöra för hur influencer marketing kan påverka tillväxten för ett företag. Härtill studeras influencers inverkan på varumärkesbyggandet i relation till tillväxt. Följande kommer en fallstudie i samarbete med klädfö

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Tingare, Asmita. "The role of the KDM4 family histone 3 lysine 9 demethylases in hypertrophic remodelling of cardiac myocytes." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648522.

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Santos, Bruno Marinho. "Extensões do metamodelo KDM para apoiar modernizações orientadas a aspectos de sistemas legados." Universidade Federal de São Carlos, 2014. https://repositorio.ufscar.br/handle/ufscar/593.

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Made available in DSpace on 2016-06-02T19:06:20Z (GMT). No. of bitstreams: 1 6500.pdf: 5345644 bytes, checksum: e886844b4ba61e58d704a8babf113721 (MD5) Previous issue date: 2014-10-21<br>Maintaining legacy systems is a complex and expensive activity for many companies. A recently proposal to solve this problem is Architecture-Driven Modernization (ADM), proposed by Object Management Group (OMG). The ADM consists of a set of concepts and standard metamodels that support systems modernization using models. The Knowledge Discovery Metamodel (KDM) is the main metamodel of ADM, it can represent ma

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Zhaunova, Liudmila. "Regulation of oocyte-specific chromatin organisation during prophase I by the histone demethylase Kdm5/Lid and other proteins." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/29007.

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In Drosophila oocytes, chromosomes undergo dynamic reorganisation during the prophase of the first meiotic division. This is essential to prepare chromatin for synapsis, recombination and consequent chromosome segregation. The progression of meiotic prophase I is well described, while the molecular mechanisms and regulation of these dramatic chromosomal reorganisations are not well understood. Histone modifying enzymes are major regulators of chromatin structure, however, our knowledge of their roles in meiotic prophase I is still limited. In this work, I investigated the role of the histone d

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Armini, Monica. "Religionens plats i ett sekulärt politiskt landskap : Hur förhåller sig svensk kristdemokrati till det kristna över tid?" Thesis, Umeå universitet, Institutionen för idé- och samhällsstudier, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-184720.

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Detta arbete i religionsvetenskap har sökt finna svaret på hur svensk kristdemokrati harförändrats över tid med avseende på dess förhållande till begreppen kristen och kristendom.Källmaterialet har utgjorts av partiprogram, och dessa har undersökts för att ringa införekomst och kontext av ovan nämnda begrepp. Avsikten har varit att ta reda på partietsförhållningssätt till just det begrepp man en gång enades kring när man valde att ta sig anrikspolitiken — nämligen kristendomen. Dels görs en kvantitativ sammanställning, delsundersöks de sammanhang där orden används och om dessa har ändrats med

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Zibetti, C. "ALTERNATIVE SPLICING AND PHOSPHORYLATION PROVIDE A MECHANISTIC BASIS FOR FUNCTIONAL SPECIALIZATION OF LSD1/KDM1 HISTONE DEMETHYLASE IN THE CENTRAL NERVOUS SYSTEM." Doctoral thesis, Università degli Studi di Milano, 2010. http://hdl.handle.net/2434/150261.

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Chromatin represents the physiological substrate of epigenetic regulation, underlying several biological processes, from replication and transcriptional activity to cell lineage commitment and adaptation in response to specific cues. In the central nervous system, chromatin integrates a plethora of converging signaling pathways, leading to short- and long-term changes in gene expression that are crucial for neuronal commitment, terminal differentiation and neuroplasticity throughout life. Although a variety of ubiquitously expressed chromatin-remodeling complexes assist tissue-specific transcr

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Durelli, Rafael Serapilha. "Uma abordagem para criação, reúso e aplicação de refatorações no contexto da modernização dirigida a arquitetura." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/55/55134/tde-29092016-145938/.

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A Modernização Dirigida a Arquitetura (do inglês - Architecture-Driven Modernization (ADM)) é uma iniciativa do Object Management Group (OMG) no sentido de padronizar os tradicionais processos de reengenharia de software utilizando metamodelos. O metamodelo mais importante da ADM é o Knowledge Discovery Metamodel (KDM), cujo objetivo é representar todos artefatos de um determinado sistema, de forma independente de linguagem e plataforma. Um passo primordial durante processos de modernização de software é a aplicação de refatorações. No entanto, até o presente momento, há carência de abordagens

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Lopes, Daniel Barsi. "Juventude e cidadania: usos das mídias digitais na ONG Aldeia, em Fortaleza, e no projeto KDM, em Barcelona." Universidade do Vale do Rio dos Sinos, 2012. http://www.repositorio.jesuita.org.br/handle/UNISINOS/4156.

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Submitted by Silvana Teresinha Dornelles Studzinski (sstudzinski) on 2015-07-02T17:50:56Z No. of bitstreams: 1 Daniel Barsi Lopes.pdf: 3238818 bytes, checksum: 1c3f18fd295305bd203e3e46aa518391 (MD5)<br>Made available in DSpace on 2015-07-02T17:50:56Z (GMT). No. of bitstreams: 1 Daniel Barsi Lopes.pdf: 3238818 bytes, checksum: 1c3f18fd295305bd203e3e46aa518391 (MD5) Previous issue date: 2012<br>CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>FUNCAP - Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico<br>Esta pesquisa analisa os processos sociocomu

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17

Granberg, Caroline. "Socioeconomic and sociodemographic differentials in pregnant women’s knowledge on prevention of mother-to-child HIV transmission in Kenya: A cross-sectional study from 2008-09 KDHS." Thesis, Uppsala universitet, Internationell mödra- och barnhälsovård (IMCH), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-253890.

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Background: Human immunodeficiency virus (HIV) is a global public health issue. One way of transmission is through mother-to-child transmission (MTCT). There are ways to prevent this and one option is to give the mother special drugs during pregnancy, delivery or afterwards. Socioeconomic and sociodemographic factors can potentially affect the knowledge women have about prevention of mother-to-child transmission (PMTCT). Objective: The aim of this secondary analysis was to explore which socioeconomic and sociodemographic factors are associated with pregnant women’s knowledge about PMTCT. Metho

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Fassauer, Georg Michael [Verfasser], Andreas [Akademischer Betreuer] Link, Andreas [Gutachter] Link, and Gerhard [Gutachter] Scriba. "Modulatoren epigenetischer Regulationsmechanismen: Medizinische Chemie neuer KDM4-Inhibitoren und Methodenentwicklung zur SFC-MS-Analytik von Ketaminmetaboliten / Georg Michael Fassauer ; Gutachter: Andreas Link, Gerhard Scriba ; Betreuer: Andreas Link." Greifswald : Ernst-Moritz-Arndt-Universität, 2018. http://d-nb.info/1170321658/34.

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Stenstad, Victoria. "Konsumenternas krav på varumärket: Prata med oss, ge oss erbjudanden och inspirera : En kvantitativ studie om svenska kvinnors konsumtionsvanor, upplevelser och åsikter kopplat till NA-KD’s innehåll på Instagram." Thesis, Högskolan i Gävle, Media- och kommunikationsvetenskap, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-33267.

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The purpose of the study is to investigate the respondents’ consumption habits, experiences and opinions linked to NA-KD’s content on Instagram, to see which of the four communication models within PR (Grunig & Hunt 1984) that are reflected in their experiences, opinions and consumption. Method: The study is based on a quantitative web survey, which was answered by Swedish women, aged 16-35, who follows @nakdfashion on Instagram. They answered questions about their consumption of the content as well as their experiences and opinions on how NA-KD communicates with their followers. Resul

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Di, Francesco Nathalie. "Early Childhood Educators' Knowledge of Developmental Milestones (KDM) and Appropriate Play Materials (KPM) in Relation to their Developmentally Appropriate Practices (DAP) in Child Care Centres in Quebec." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/19959.

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The quality of early childhood education and care programs greatly impacts children’s development and well being. The classroom environment, program content and approach and early childhood educators’ characteristics are some of the elements that influence quality and thus have effects on young children’s development. Past research has indicated that early childhood education and care programs in Quebec have received on average low/minimal or mediocre ratings of quality and were also found to lack developmentally appropriate play materials (Drouin, Bigras, Fournier, Desrosiers, & Bernard, 2004

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Honda, Raphael Rodrigues. "Modelagem e cômputo de métricas de interesse no contexto de modernização de sistemas legados." Universidade Federal de São Carlos, 2014. https://repositorio.ufscar.br/handle/ufscar/587.

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Made available in DSpace on 2016-06-02T19:06:19Z (GMT). No. of bitstreams: 1 6441.pdf: 3762020 bytes, checksum: cf0babba26cd55b52382a3a068029d68 (MD5) Previous issue date: 2014-10-13<br>Universidade Federal de Sao Carlos<br>Maintaining legacy systems is a complex and expensive activity for many companies. An alternative to this problem is the Architecture-Driven Modernization (ADM), proposed by the OMG (Object Management Group). ADM is a set of principles that support the modernization of systems using models. The Knowledge Discovery Metamodel (KDM) is the main ADM metamodel and it is able t

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Boullosa, Allariz Beatriz. "Déshydratation naturelle et mécanisée de sédiments : étude des processus mis en jeu et applications." Thesis, Normandie, 2018. http://www.theses.fr/2018NORMC285/document.

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Les opérations de dragage génèrent d’importants volumes de sédiments à teneur en eau élevée qui sont difficilement transportables. Toute opération de valorisation ou stockage des sédiments implique de réduire la teneur en eau. Le séchage naturel et la déshydratation mécanisée des sédiments répondent à cette attente. Le séchage naturel des sédiments est la technique de déshydratation la plus économique et la meilleure du point de vue environnemental. Le temps de séchage peut être réduit par des moyens techniques adaptés (retournement, scarification) mis en action par l'application de critères d

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23

Wang, Zhuo. "Genetic studies of genes involved in the initiation of DNA replication in the fission yeast Schizosaccharomyces pombe." Wright State University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=wright1284475548.

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Brunet, Johansson Albert. "Kristen värdegrund : En studie av Kristdemokratiska samhällspartiets utbildningspolitiska ställning i frågan om konfessionella friskolor åren 1984-1994." Thesis, Umeå universitet, Institutionen för idé- och samhällsstudier, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-157142.

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This study has investigated how the Swedish Christian Democratic Party (KDS) argued for the right of private actors to operate tax-funded schools outside of the public sector – charter schools. The hypothesis of this study was that KDS were openly positive to such a reform and saw it as a chance to run state-funded confessional schools.The study examined political texts produced by the party during a ten-year period, ranging from 1984 to 1994. The study’s methodological approach was one of a qualitative textual analysis, aided by a theoretical framework adapted from Samuel Moyn’s thesis in his

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Dedeurwaerder, Sarah. "Biological and clinical relevance of epigenetic modifications in human breast cancers." Doctoral thesis, Universite Libre de Bruxelles, 2011. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209896.

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It is increasingly recognized by the scientific community that the field of epigenetics is a key step for a better understanding of human biology in both normal and pathological states. Its implication in cancer, and in particular in breast cancer, is now well accepted. Breast cancer, responsible for more than 450,000 deaths worldwide yearly, is a heterogenous disease at the histological and clinical levels as well as at the molecular level. Despite considerable efforts to develop new treatments and improve patient management, patients with a same “profile” of breast cancer can respond differe

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Krůpa, Tomáš. "Univerzální zavaděč pro mikrokontrolér Kinetis K60." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2016. http://www.nusl.cz/ntk/nusl-255480.

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The scope of this work was to design a bootloader for Kinetis K60, an ARM Cortex-M4 microcontroller. The bootloader should simplify the process of loading user applications to the flash memory of the microcontroller on the Minerva development kit. Based on a quick research of existing bootloader solutions, new bootloader was designed together with communication protocol that would suit the needs for transfer of both the file data and configuration information through all the supported communication interfaces - USB, SDHC, Ethernet and RS-232. On the PC side, development of bootloader’s a

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Santibáñez, Daniel Gustavo San Martín. "Mineração de interesses no processo de modernização dirigida a arquitetura." Universidade Federal de São Carlos, 2013. https://repositorio.ufscar.br/handle/ufscar/549.

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Made available in DSpace on 2016-06-02T19:06:09Z (GMT). No. of bitstreams: 1 5515.pdf: 2859644 bytes, checksum: 8f2473af784eb07ff38067a957051dde (MD5) Previous issue date: 2013-08-27<br>Universidade Federal de Sao Carlos<br>Software systems are considered legacy when they were developed many years ago with outdated technologies and their maintenance process consumes a large amount of resources. One cause of these problems is the inadequate modularization of its crosscutting concerns. In this situation, an alternative is to modernize the system with a new language to provide better support fo

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楊所芳. "The Role of KDM8 in Breast Cancer Cells: Cell Proliferation and Migration." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/15474248973694324183.

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Lin, Tung-Yueh, and 林東岳. "Discovery and Modification of KDM4 Inhibitors in Castration-Resistant Prostate Cancer Treatment." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/zytbkf.

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Lin, Chun-Pu, and 林均璞. "KDM8, an H3K36me2 Histone Demethylase, Regulates Normoxia and Hypoxia Mediated Breast Cancer Cell Proliferation." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/83500026616238105727.

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碩士<br>國立清華大學<br>分子與細胞生物研究所<br>101<br>Methylation/demethylation of histone tail, one of the major post-translational modifications (PTMs) in chromatin, plays an important role in chromatin remodeling to regulate gene expression. Dysregulation of these processes links to carcinogenesis. KDM8 (Jmjd5), an H3K36me2 histone demethylase containing jmjC domain, is crucial to regulate embryonic development, osteoclastogenesis and cell proliferation. Along with its general over expression in breast cancer, KDM8 is suggested to play a role in carcinogenesis. Swiftly proliferating cancer cells that encoun

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Tilsch, Jan. "Proces s "vedením ilegální protistátní skupiny KDS" v roce 1955 a procesy s ním spojené." Doctoral thesis, 2015. http://www.nusl.cz/ntk/nusl-349344.

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Main Content of this Work is to describe in detail Part of political Trials in Czechoslovakia during the first Part of 1950's, focused against political Opponents coming from Czechoslovak People's Party (ČSL) or Roman Catholic. The Topic - political Trial with "Leaders of illegal anti-state Group Christian-Democratic Party (KDS)" in 1955 and related Trials - is almost unprocessed. The Goal of this Work is to sketch long-lasting "crusade", managed by the communist Power, against "virtual political Entity KDS". This "crusade" should culminate by public political Trial with Leaders of KDS. I'd li

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HWANG, SUNHEE. "Efforts to Elucidate the Binding Interaction between Lysine-Specific Demethylase 1 (LSD1/KDM1) and CoREST and Their Roles in Breast Cancer." Diss., 2012. http://hdl.handle.net/10161/5821.

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<p>Histone modifications play important roles in regulating gene expression in various cellular processes by altering the underlying chromatin structure and thus influencing related pathological conditions. Histone methylation is one such modification that was thought to be static and enzymatically irreversible until the recent discovery of histone demethylases. Lysine specific demethylase 1 (LSD1) is a unique histone demethylase that removes methyl groups on lysine residues and mediates expression of many genes important in cancer progression. LSD1 activity and its substrate specificity are m

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Gronau, Marny [Verfasser]. "Prognosefaktoren für die Entscheidung mono- oder bignather Eingriffe in der orthognathen Chirurgie hinsichtlich der Modell-OP mit dem KDMMS-System / vorgelegt von : Gronau, Marny." 2010. http://d-nb.info/1010015060/34.

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