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1
GRENIE, LOIC. « VALEURS SPECIALES DE FONCTIONS L DE GL(R) x GL(R) ». Paris 7, 2000. http://www.theses.fr/2000PA077100.
Texte intégralRésumé :
Nous demontrons dans cette these un resultat qui etend le resultat de h. Hida sur les valeurs speciales de fonctions l automorphes de gl(2) gl(2) au groupe gl(r) gl(r). Les donnees sont deux representations automorphes paraboliques (irreductibles) de gl(r). Nous utilisons la representation integrale de cette fonction l donnee par h. Jacquet et j. A. Shalika, ce qui introduit une serie d'eisenstein d'une representation induite d'un sous-groupe parabolique maximal de gl(r). Nous pouvons alors interpreter cette serie d'eisenstein comme le residu d'une serie d'eisenstein provenant du sous-groupe de borel. Nous relions ensuite ces valeurs speciales au cup-produit de classes de cohomologie (relative) d'algebre de lie. Les resultats de l. Clozel sur la descente aux structures rationnelles et celui de g. Harder sur la rationnalite des residus de series d'eisenstein provenant du sous-groupe de borel donnent alors des informations sur les valeurs speciales. Le resultat obtenu est qu'a un nombre algebrique pres, la valeur speciale est un produit de trois nombres, dependant chacun d'une seule des trois representations considerees, divise par une integrale archimedienne. Comme les k-types supportant la cohomologie ont ete calcules, il ne reste qu'a prouver la non nullite de l'integrale archimedienne ou meme a la calculer.
2
Thiercelin-Panais, Jean-Marc. « L. S. Catégorie d'un espace R-modéré ». Lille 1, 1997. http://www.theses.fr/1997LIL10086.
Texte intégralRésumé :
A partir de l'algebre des cochaines singulieres de l'espace x a coefficients dans un anneau principal r, nous definissons les invariants mcat(x;r) et acat(x;r) en generalisant les definitions donnees par s. Halperin et j. M. Lemaire. Lorsque l'homologie de l'espace des lacets sur r est r-libre, l'espace x admet un modele minimal decomposable commutatif qui joue le role du modele de sullivan lorsque r = q. En mimant les definitions rationnelles nous introduisons les invariants m#ccat et a#ccat. Nous demontrons alors que pour un cw complexe r-modere, au sens de d. Anick, tel que l'homologie de l'espace des lacets sur r et la cohomologie de l'espace x sur r soient r-libres, nous avons m#ccat(x;r) = a#ccat(x;r). Puis a partir de la demonstration rationnelle, nous etablissons que m#ccat(xxs#n;r) = a#ccat(x;r) + 1. Lorsque r est un corps de caracteristique plus grande que la dimension de x, comme l'ont montre s. Halperin et j. M. Lemaire, nous avons m#ccatx = mcatx et a#ccatx acatx. Il en resulte dans ces conditions que mcat(x;r) = acat (x;r) ce qui constitue une generalisation du resultat obtenu par k. Hess dans le cas rationnel. De plus nous avons aussi acat(x x s#n;r) = acat(x;r) + 1 ce qui signifie que acat (-;r) verifie la conjecture de ganea.
3
Le, Livec-Tourneux Martine. « E. U. R. L. Et regimes matrimoniaux ». Nantes, 1990. http://www.theses.fr/1990NANT4003.
Texte intégralRésumé :
Le mariage constitue la norme en france. Les epoux se marient sans contrat et investissent des biens communs. Lorsque le statut d'eurl est choisi, la limitation de responsabilite liee a l'eurl, le pouvoir accorde au seul associe s'opposent a l'egalite et a la solidarite des epoux qui resultent de la communaute legale. La loi creant l'eurl fut decriee sur les consequences qui resultent de la coexistence du statut d'eurl et du regime legal. Il etait donc interessant de degager les inconvenients et les avantages de cette coexistence et de rechercher, s'il en existe, les solutions matrimoniales les mieux appropriees. Constituer une eurl necessite un minimum de formation et d'informations. Mais le statut d'eurl est rellement adapte a la vie des petites entreprises et aucun regime matrimonial n'est a proscrire. L'important est que l'entrepreneur connaisse exactement les avantages et les inconvenients de la combinaison qu'il a adopteeMarriage is the standard habit in france. Husbands and wifes are used to get married without any marriage settlement and invest common funds. When they choose the charter of eurl, limitation of accountability and power confered to the only partner arised from eurl stand in opposition to equality and solidarity issued from legal marriage settlement. Law creating eurl was run down because of the consequences of the charter of eurl and legal marriage settlement coexistence. It is therefore interesting to isolate disdvantages and benefits issued from this coexistence and to look for marriage settlements which fit best. To set up an eurl requires a minimum training and informations. The charter of eurl is truely adapted to small firms. No marriage settlement ought to be avoided. A partner in a eurl must only exactly know advantages and disadvantages of the embraced combination
4
D'Alonzo, Giovanna. « Il diagramma h-r ». Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amslaurea.unibo.it/6487/.
Texte intégralRésumé :
Il diagramma H-R:
- la definizione e la costruzione del diagramma H-R;
- le classi principali di stelle nel diagramma H-R;
- massa e raggio delle stelle nel diagramma H-R;
- diagramma H-R ed evoluzione stellare;
- il diagramma osservativo (magnitudine-colore);
- diagramma CM di ammassi stellari;
- le sequenze evolutive nel diagramma CM;
- le reazioni termonucleari connesse a ciascuna fase evolutiva.
5
Pettinari, Paolo. « Teorie della gravitazione f(R) ». Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amslaurea.unibo.it/9118/.
Texte intégralRésumé :
Tra tutti i fenomeni naturali osservabili, ne era presente uno particolarmente interessante e con il quale si aveva diretto contatto quotidianamente: la gravità.
Dopo le innumerevoli osservazioni astronomiche effettuate da Galileo, fu Newton nel diciassettesimo secolo a capire che il moto dei pianeti era governato dalle medesime leggi che descrivono la caduta dei gravi sulla Terra e fu quindi lui che ci fornì una prima teoria della gravità con la quale si spiegarono le orbite dei pianeti con ottima precisione.
Grazie al contributo di Einstein, la teoria si rinnovò e si arricchì, ma rimase pur sempre lontana dall' essere completa, tant' è che ancora oggi sono presenti molte domande a cui non siamo in grado di rispondere. In questo articolo ci occuperemo di tali quesiti, provando a formulare una teoria che sia in accordo con le attuali evidenze sperimentali.
Nella prima parte, tratteremo le ragioni che hanno spinto i ricercatori ad introdurre le nuove teorie della gravità f(R); in particolare vedremo la peculiarità delle curve di rotazione delle galassie e perché ci sia il bisogno di tirare in ballo la materia oscura. Discuteremo anche alcuni problemi derivanti dall' evoluzione cosmica e altre incongruenze riguardanti la stabilità delle stelle di neutroni.
In seguito mostreremo come ricavare l' equazione di Einstein partendo dai principi variazionali di Hamilton, e estenderemo tale ragionamento con lo scopo di ottenere un' equazione corrispondente ad una gravità modificata.
Infine, verranno introdotte le teorie della gravità f(R), per mezzo delle quali cercheremo di discutere alcune possibili spiegazioni alle problematiche mosse nella parte introduttiva.
6
Khafizov, Farid T. « Descriptions and Computation of Ultrapowers in L(R) ». Thesis, University of North Texas, 1995. https://digital.library.unt.edu/ark:/67531/metadc277867/.
Texte intégralRésumé :
The results from this dissertation are an exact computation of ultrapowers by measures on cardinals $\aleph\sb{n},\ n\in w$, in $L(\IR$), and a proof that ordinals in $L(\IR$) below $\delta\sbsp{5}{1}$ represented by descriptions and the identity function with respect to sequences of measures are cardinals. An introduction to the subject with the basic definitions and well known facts is presented in chapter I. In chapter II, we define a class of measures on the $\aleph\sb{n},\ n\in\omega$, in $L(\IR$) and derive a formula for an exact computation of the ultrapowers of cardinals by these measures. In chapter III, we give the definitions of descriptions and the lowering operator. Then we prove that ordinals represented by descriptions and the identity function are cardinals. This result combined with the fact that every cardinal $<\delta\sbsp{5}{1}$ in $L(\IR$) is represented by a description (J1), gives a characterization of cardinals in $L(\IR$) below $\delta\sbsp{5}{1}. Concrete examples of formal computations are shown in chapter IV.
7
Quest, Matthew. « C. L. R. James, direct democracy, and national liberation struggles ». View abstract/electronic edition ; access limited to Brown University users, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3318351.
Texte intégral
8
Dearman, Brian. « Synthesis and characterization of [(C₅R₅)M(CO)₂(L₂)+:R=H, Me, and Ph ; M=Cr and Mo ; L₂=dmpe and dppe ». Huntington, WV : [Marshall University Libraries], 2002. http://www.marshall.edu/etd/descript.asp?ref=125.
Texte intégral
9
West, Paula. « Long-distance coarticulatory effects of English /l/ and /r/ ». Thesis, University of Oxford, 2000. http://ora.ox.ac.uk/objects/uuid:52cb3c89-6ec9-4f21-b219-aae92c0c6660.
Texte intégralRésumé :
This thesis explores the coarticulatory effects of English /l/ and /r/, examining their articulatory basis, acoustic manifestation and perceptual relevance. It demonstrates that there are perceptually relevant coarticulatory differences associated with the distinction between /l/ and /r/. Two perceptual experiments, an articulatory experiment and a modelling study were conducted. Both perceptual experiments used a modified gating technique. The first experiment demonstrates that the coarticulatory effects of /l/ and /r/ on surrounding vowels and consonants can sometimes be used by listeners to identify an HI or /r/ which has been deleted and replaced by noise. The second perceptual experiment shows that the cues for an /r/ are more perceptually salient than those for an /l/. The articulatory experiment used simultaneous electromagnetic articulography, electropalatography and acoustic recordings to investigate the coarticulatory effects of /l/ and /r/. In /r/ contexts, relative to /l/ contexts, raising and retraction of the tongue, lip rounding and lowering of F₃ were found, up to two syllables preceding and following the /r/. The extent of this coarticulatory effect is far greater than commonly acknowledged in the coarticulation literature. Phonetic and phonological theories fail to predict or account for effects of this extent. The theory that coarticulation can be modelled as overlap of articulatory gestures was tested in a modelling study. A subset of the articulatory data was modelled numerically using dynamical descriptions of articulatory gestures from an approach developed at Haskins Laboratories. The modelling showed that longdistance coarticulatory effects could not be adequately accounted for by gestural overlap alone. Feature-spreading models, such as Keating's window model of coarticulation, are also unable to account for these effects adequately. The results of this thesis pose a challenge to current phonetic and phonological theory, as they show that coarticulatory effects have greater extent than commonly recognised.
10
Newman, Andrew. « The regulation of L-selectin activity by proteolysis ». Thesis, Cardiff University, 2017. http://orca.cf.ac.uk/103855/.
Texte intégralRésumé :
L-selectin (CD62L) is a type I transmembrane protein expressed by lymphocytes which directs their migration from the bloodstream into lymph nodes and infected tissues. Stimulation of the T cell receptor (TCR) activates the enzyme A Disintegrin and Metalloproteinase 17 (ADAM 17), which cleaves L-selectin at the ectodomain generating a metalloproteinase product (MP product) comprising of a transmembrane region and a 17-amino acid intracellular domain (ICD). ϒ-secretase is a multi-subunit protease that cleaves up to 90 identified type I transmembrane proteins in the intramembrane region following ectodomain proteolysis by metalloproteinases. Presenilin (PS), the catalytic component of γ-secretase is activated during an intramolecular cleavage called endoproteolysis separating the carboxy (C) and amino (N) termini. The catalytically active C-terminal fragment of PS then induces intramembrane proteolysis of substrates. The aim of my thesis was to firstly determine whether the MP product of L-selectin was a substrate for PS. Subsequently, I analysed whether stimulation of the TCR activates PS, inducing intramembrane proteolysis of the MP product releasing the ICD into the intracellular region. My data showed for the first time that in a resting T-cell, L-selectin forms a multi-component complex with both ADAM 17 and PS. TCR-activation induces ADAM 17 dependent proteolysis of L-selectin generating an MP product. Stimulation of the TCR also causes endoproteolysis of PS, where activated PS then cleaves the bound MP product. After PS cleavage, the released ICD was unstable and therefore difficult to detect, however I was able to block its formation using either PS inhibitor treatment or generating I351W mutated L-selectin, which was resistant to intramembrane proteolysis.
11
De, Cian Valentina. « R-Moduli Iniettivi e Proiettivi ». Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2017. http://amslaurea.unibo.it/13565/.
Texte intégralRésumé :
L'elaborato tratta dei moduli iniettivi e proiettivi. La prima parte descrive le proprietà di somme e prodotti diretti di moduli; successioni esatte di moduli e omomorfismi. La seconda parte riguarda gli R-moduli liberi, proiettivi e iniettivi, approfondendo in particolar modo i moduli su di un dominio a ideali principali, e i gruppi abeliani divisibili.
12
Pacilli, Marco. « Stabilita di sistemi sferici autogravitanti con forze r^(-α) ». Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amslaurea.unibo.it/12044/.
Texte intégralRésumé :
In questa tesi si è eseguito uno studio preliminare (con risultati positivi) volto a verificare la possibilità di estendere al caso di forze r^(-α) il Teorema di stabilità di Antonov per sistemi autogravitanti newtoniani.
Tale studio è volto a capire se i risultati di stabilità attualmente noti dipendano dalla speciale natura del campo r^(-2) o se valgono più genericamente per sistemi con forze a lungo range.
13
Arafeh, Rami M. « Molecular phylogeography of the European coastal plants Crithmum maritimum L., Halimione portulacoides (L.) Aellen, Salsola kali L. and Calystegia soldanella (L.) R. Br ». [S.l. : s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=975913565.
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14
Valencia, Domènech Enric. « Ocean monitoring using L-Band microwave radiometry and GNSS-R ». Doctoral thesis, Universitat Politècnica de Catalunya, 2012. http://hdl.handle.net/10803/96989.
Texte intégralRésumé :
The knowledge of sea surface salinity (SSS) is a key issue to understand and monitor the Earth¿s water cycle. Accurate and systematic measurement of SSS was not possible until the ESA¿s Soil Moisture and Ocean Salinity (SMOS) mission was launched in 2009. The SMOS mission uses L-band microwave radiometry to infer SSS from measurements of the ocean¿s emis- sivity. However, the ocean surface emissivity is not only dependent on SSS, but also on sea surface temperature (SST), incidence angle, polarization, and sea surface roughness (i.e. sea-state). While the dependence on most of these parameters is well-known, and can be properly accounted for, the accurate estimation and correction of the sea surface roughness contribution remains a challenge.
The Passive Advanced Unit (PAU) project was born in 2003 with the main objective of studying how to correct ocean L-band brightness temperature for the sea-state effect by using an emerging technology such as reflectome- try of opportunity GNSS signals (GNSS-R). GNSS-R is based on measuring the forward scattered GNSS signals so as to infer geophysical properties of the scattering surface. Particularly, the PAU project proposed to use direct observables from the reflected signal¿s Delay-Doppler Map (DDM) to parame- terize sea surface roughness, and link those observables to the brightness tem- perature variations induced by sea-state, without using scattering/emissivity models. In this line, prior work was performed by J.F. Marchan-Hernandez in his PhD. Thesis (UPC, Barcelona, 2009). In that work, a first version of the PAU GNSS-R receiver was developed, and first experimental results were obtained that supported the hypothesis that direct GNSS-R observables can be used to describe sea-state.
This PhD. Thesis follows on that research, and steps into the use of GNSS- R observables for estimation of the sea-state contribution to the ocean L-band brightness temperature. The work presented here was undertaken between 2008 and 2012, and comprises contributions to three main fields: GNSS-R hardware development, experimental results, and theoretical studies. Firstly, the PAU GNSS-R instrument was re-designed and re-implemented for im- proved sensitivity and stability. Secondly, results from ground-based and airborne experiments were obtained, that prove the hypothesis that GNSS-R observables can be used to successfully correct L-band brightness tempera- ture for the sea-state effect, resulting in an improvement in the SSS retrieval accuracy. Finally, theoretical studies to foresee the performance of the PAU concept in a future spaceborne mission were conducted, along with the de- velopment of a new technique to obtain ocean surface scattering coefficient images from measured DDMs.
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Chen, Yi-Chun. « Bioactivities of selected Sutherlandia frutescens (L.) R. Br. leaf extracts ». Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/5035.
Texte intégralRésumé :
Thesis (M.S.)--University of Missouri-Columbia, 2007.The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on October 23, 2007) Includes bibliographical references.
16
Faure, Sebastien. « Genetic studies in pearl millet (Pennisetum glaucum (L.) R. Br.) ». Thesis, University of East Anglia, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.405723.
Texte intégral
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FERREIRA, Ester. « Vocalização dos fonemas /l/ e /r/ pós-vocálicos : Jaraguá-Goiás ». Universidade Federal de Goiás, 2010. http://repositorio.bc.ufg.br/tede/handle/tde/2403.
Texte intégralRésumé :
Made available in DSpace on 2014-07-29T16:19:04Z (GMT). No. of bitstreams: 1
Dissertacao Ester Ferreira - parte textual.pdf: 2725317 bytes, checksum: 27c85cd69f334485ffaa34307f93572a (MD5)
Previous issue date: 2010-10-06This research is an investigative study of a descriptive, comparative and interpretive nature under the auspices of the Historical Linguistics. This study presents the analysis of the vocalization of postvocalic /l/ and /r/ in speech community of Jaraguá, located in the midwest of Goiás, Brazil. In the process of vocalization, the /l/ is replaced by [y] and /r/, whose analyzed variant is [ö], with [y] and [w], providing falling diphthongs (vowel + semivowel). The postvocalic vocalization occurs in CVC and CV syllables within words, for example, salgada > saygada, alma > ayma, garfo > gayfu ~ gawfu; at the end of words the process of erasure or resyllabication predominated, as in enxoval > inxovali ~ inxová, cobertor > cubeytori ~ cubeytô. The sample group consists of 17 speakers (male and female) above 65 years old, born near the town, or people that have lived for more than 50 years in the place, with little or no level of literacy. We applied the technique of data collection based on the methodological assumptions of Ethnography, adopting a semi-structured interview. The themes of the interviews were directed to narratives and dialogues about family, childhood, migration, religious, cultural and professional activities, and especially about history and the beginning of the locality. The focus is primarily phonological, so it is used the terminology of this area of Linguistics. The theoretical section presents the main theories and methods of Historical Linguistics from the perspectives of Paixão de Sousa (2005-2009), Silva (1973), Coutinho (1975), Campbell (2004), Maurer Jr. (1951), Faraco (2005), Callou e Leite (1993) and Ladefoged e Maddieson (1996). The discussion and presentation of the Brazilian Portuguese Language and its structural system is based on theorists such as Ilari (1990), Ilari e Basso (2006), Mattos e Silva (2004), Camara Jr. ([1970] 2008a - [1953] 2008b), Amaral (1976), Jakobson (1967) and others. Theoretically, the process of postvocalic vocalization is shown and discussed on the perspectives by Camara Jr. ([1953] 2008a - [1970] 2008b), Coutinho (1975), Elia (1979), Silva (2008), Melo (1981), Moura (1993), Vieira (1983), Silva Neto (1988) among others. Given these theoretical and methodological assumptions, it is considered, in the analysis of data, the synchronic and diachronic criteria of postvocalic vocalization, in the intralinguistic perspective. In a diachronic point of view, we observe the evolution from Latin to Portuguese, and from the synchronic point of view, the occurrences of the speech community of Jaraguá, comparing them to recent studies from other regions of the country.
A presente pesquisa caracteriza-se por ser um estudo investigatório de natureza descritiva, comparativa e interpretativa sob os auspícios da Linguística Histórica. Este estudo apresenta a análise da vocalização dos fonemas /l/ e /r/ pós-vocálicos na comunidade de fala de Jaraguá, localizada na região Centro-Oeste do Estado de Goiás, Brasil. Nesse processo de vocalização, o /l/ é substituído por [y] e o /r/, cuja variante analisada é [ö], por [y] e [w], criando ditongos decrescentes (vogal + semivogal). A vocalização ocorre em sílabas CVC e VC, no interior de palavras em posição pós-vocálica, por exemplo, salgada > saygada, alma > ayma, garfo > gayfu ~ gawfu; em final de palavras predominam os processos de apagamento ou de ressilabação, como em enxoval > inxovali ~ inxová, cobertor > cubeytori ~ cubeytô. O grupo de amostra é constituído por 17 falantes (homens e mulheres), acima de 65 anos de idade, nascidos nas proximidades do município, ou com mais de 50 anos de residência na localidade, com pouco ou nenhum nível de letramento. Empregou-se a técnica de coleta de dados baseada nos pressupostos metodológicos da Etnografia, adotando a entrevista semi-estruturada. Os temas das entrevistas foram direcionados às narrativas e diálogos sobre família, infância, migrações, atividades religiosas, culturais, profissionais e, principalmente, sobre a história e o surgimento do lugar. O foco deste trabalho é fundamentalmente fonológico, portanto são utilizadas as terminologias dessa área da Linguística. A fundamentação teórica apresenta as principais teorias e métodos da Linguística Histórica a partir das perspectivas de Paixão de Sousa (2005-2009), Silva (1973), Coutinho (1975), Campbell (2004), Maurer Jr. (1951), Faraco (2005), Callou e Leite (1993) e Ladefoged e Maddieson (1996). A discussão e apresentação da Língua Portuguesa do Brasil e do seu sistema estrutural encontram-se baseadas em teóricos como Ilari (1990), Ilari e Basso (2006), Mattos e Silva (2004), Camara Jr. ([1970] 2008a [1953] 2008b), Amaral (1976), Jakobson (1967) e outros. Teoricamente, o processo da vocalização pós-vocálica é mostrado e discutido nas perspectivas de Camara Jr. ([1953] 2008a [1970] 2008b), Coutinho (1975), Elia (1979), Silva (2008), Melo (1981), Moura (1993), Vieira (1983), Silva Neto (1988) dentre outros. Diante desses postulados teóricos e metodológicos, são considerados, na análise dos dados, os critérios diacrônicos e sincrônicos da vocalização pós-vocálica, na perspectiva intralinguística. Do ponto de vista diacrônico são observadas as evoluções do Latim ao Português; e do ponto de vista sincrônico, as ocorrências da fala da comunidade de Jaraguá, comparando-as com estudos recentes de outras regiões do país.
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Costa, Vera Lucia Anunciação. « A alternância /l/ - /r/ no grupo consonantal em Botelhos - MG ». reponame:Repositório Institucional da UFPR, 2012. http://hdl.handle.net/1884/24381.
Texte intégralRésumé :
Resumo: O presente trabalho trata da alternância entre as liquidas no grupo conso antal no dialeto de Botelhos (fl.6. } , investigada sob a perspectiva da Teoria da Variação. De acordo com o modelo, são levantados condicionamentos sociais e lingüísticos que possam influenciar na escolha das variantes /l/ ou /r/. Os resultados mostram que o fenômeno apresenta correlção em menor ou maior grau com os fatores sociais estratificados - sexo,idade e escolaridade - com os fatores não estratificados - mídia, sensibilidade lingüistica e background rural - bem como com os fatores lingüísticos contextos fonológicos precedentes e seguintes.
19
Liozon, Eric. « Les lymphomes o. R. L. : a propos de 20 cas ». Limoges, 1988. http://www.theses.fr/1988LIMO0196.
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GRADELLE, SYLVIE. « L'analgesie post-operatoire chez l'enfant en chirurgie o. R. L ». Lille 2, 1992. http://www.theses.fr/1992LIL2M126.
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Biagi, Stefano. « Sulle misure di Hausdorff in R^N ». Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2010. http://amslaurea.unibo.it/1208/.
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Blin, St��phane. « R��alisation de lasers �� fibre �� contre-r��action r��partie pour l'��tude de l'injection optique : comparaison avec l'injection de lasers �� semi-conducteurs ». Phd thesis, Universit�� Rennes 1, 2003. http://tel.archives-ouvertes.fr/tel-00078932.
Texte intégralRésumé :
Nous pr��sentons une ��tude comparative de l'injection optique quasi-statique pour des lasers �� semi-conducteurs et des lasers �� fibre. La fabrication des lasers �� fibre �� contre-r��action r��partie est d��taill��e. L'��tude spectrale de l'injection de lasers �� semi-conducteurs pour des puissances inject��e usuelles (> -30 dBm) permet, par des cartographies, de caract��riser des r��gimes bistables, le r��gime de relaxation, et la synchronisation de chaos. Pour de faibles puissances inject��es (< -30 dBm), nous montrons que le laser esclave est un amplificateur de qualit�� pour de faibles signaux coh��rents, et observons l'attraction en fr��quance de l'esclave inject�� par le ma��tre. L'injection statique des lasers �� fibre permet d'observer une r��ponse dynamique dans le domaine temporel, li��e �� des ph��nom��nes de relaxation. Nous proposons des m��thodes de mesure, par injection optique, du facteur de Henry, de faibles largeurs spectrales, du taux d'��mission spontan��e du laser esclave.
23
Hattori, K. « Perception and production of English /r/-/l/ by adult Japanese speakers ». Thesis, University College London (University of London), 2010. http://discovery.ucl.ac.uk/19204/.
Texte intégralRésumé :
This dissertation examines perception and production of English /r/-/l/ by adult Japanese speakers. This programme of research is organized into three sections, termed Study 1, Study2, and Study 3. The first study examined whether category assimilation between English /r/-/l/ and Japanese /ɾ/ was predictive of /r/-/l/ identification accuracy using an individual difference approach. Japanese speakers were assessed in terms of /r/-/l/ identification and assimilation of English /r/-/l/ into Japanese /ɾ/, /r/-/l/ production, and perceptual best exemplars for /r/, /l/, and /ɾ/. The results demonstrated that, although Japanese speakers strongly assimilated /l/ to /ɾ/, category assimilation was not predictive of English /r/-/l/ identification accuracy, and that only Japanese speaker’s representations for F3 in /r/ and /l/ was predictive of /r/-/l/ identification ability. The second study similarly took an individual difference approach and examined whether there is a relationship between perception and production of /r/-/l/ measuring perception accuracies (i.e., identification, discrimination, and perceptual best exemplars) and production accuracies (i.e., acoustic measurements, and recognition accuracy by English speakers). The results demonstrated that perception and production of /r/-/l/ were moderately related. However, not all aspects of /r/-/l/ perception were incorporated into /r/-/l/ production. The third study examined whether one-to-one pronunciation training leads to improvement in production and perception of English /r/-/l/ using a multipronged approach (i.e., explicit instructions, real-time spectrograms, and feedback with signal-processed versions of their own productions). The results demonstrated that Japanese speakers could be trained to produce native-like English /r/-/l/, improving to the point that they approached a 100% accuracy ceiling in terms of how well native speakers could identify their productions. However, the training did not improve their English /r/-/l/ perception at all.
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Pornet, Laurence. « Infections O. R. L. Chez l'enfant de moins de huit ans ». Paris 5, 1994. http://www.theses.fr/1994PA05P071.
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RABY, FREDERIC. « La toux en o. R. L. : etiologies et conduite a tenir ». Nantes, 1989. http://www.theses.fr/1989NANT034M.
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MARLIER, ERIC. « Antibiotherapie en carcinologie o. R. L. : etude comparative de deux protocoles ». Lille 2, 1993. http://www.theses.fr/1993LIL2M085.
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Tournefier, Edwige. « Mesure du rapport r#l avec l'experience aleph a lep 1 ». Paris 11, 1998. http://www.theses.fr/1998PA112100.
Texte intégralRésumé :
Le travail effectue dans cette these s'inscrit dans le cadre des mesures de precision a lep. Les donnees enregistrees par l'experience aleph aux energies proches de la masse du boson de jauge z ont ete utilisees. La mesure precise des sections efficaces des processus e#+e#- f$$ permet d'extraire les parametres decrivant la resonance du z et d'effectuer un verification tres precise du modele standard. L'un de ces parametres, le rapport r#l est defini par le rapport des largeurs du z en hadrons et en leptons : r#l = #h#a#d/#l. Pour la mesure de r#l, une selection globale d'evenements di-leptons sans distinction de saveur (e, ou ) a ete developpee. Cette selection permet de s'affranchir des problemes introduits par la migration des evenements d'une saveur a une autre, ainsi l'incertitude systematique sur r#l provenant du canal leptonique est reduite a 0. 08 %, alors que l'incertitude statistique est de 0. 15 %. La valeur obtenue avec les mesures des sections efficaces est r#l = 20. 735 0. 039. Etant donne que r#l depend de #s a travers les corrections introduites par l'interaction forte, la valeur de #s peut etre extraite de cette mesure de r#l. On trouve #s = 0. 119 0. 007.
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Stamp, Adrienne J. « Sex allocation and gene flow in Ranunculus bulbosus L ». Thesis, University of Bath, 1990. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236481.
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Franciolini, Gabriele. « Inflazione cosmologica R^2 ». Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amslaurea.unibo.it/8857/.
Texte intégralRésumé :
Lo scopo di questa tesi è illustrare il paradigma dell’inflazione cosmologica descrivendo in particolare la teoria dell’inflazione R^2.
In una prima sezione si fa riferimento al contesto della relatività generale per descrivere l’universo su larga scala. Vengono prese in esame le ipotesi utilizzate per ottenere il modello standard della cosmologia e le principali proprietà che da esso possono essere ricavate. Si focalizza quindi l’analisi sulla descrizione dell’universo primordiale da cui traggono origine le ipotesi dell’esistenza dell’epoca inflazionaria esponendo, in particolare, come questa teoria riesca a risolvere i problemi della piattezza e dell’orizzonte cosmologico. Viene poi descritto come la fase di espansione esponenziale richiesta da queste ipotesi possa essere generata dalla presenza di un campo scalare φ specifico. Particolare risalto è dato alla descrizione dell’approssimazione di ”slow-roll” ed ai vincoli sul numero di ”e-folding”.
Una seconda sezione mostra l’applicazione dell’analisi generale esposta in precedenza al modello di inflazione di Starobinsky. A tal fine sono descritte le caratteristiche delle teorie della gravità f(R) con particolare attenzione alle trasformazioni conformi e scelta del frame. Attraverso l’esposizione delle equazioni di campo cosmologiche nella teoria della gravità R^2 si mostra come il processo di espansione inflazionaria dell’universo nelle sue fasi iniziali possa essere descritto da un comportamento non standard della gravità ad alte energie. Sono riportati i risultati principali ottenuti con questa teoria nel frame di Jordan e in quello di Einstein.
La conclusione descrive in sintesi lo stato attuale delle osservazioni sperimentali e come queste abbiano un legame stretto con la teoria delle perturbazioni cosmologiche. In particolare, presentando i risultati ottenuti nel contesto dell’inflazione R^2 ed esponendo gli ultimi dati raccolti dall’esperimento Planck, si analizza come il modello sia in accordo con i dati sperimentali attualmente disponibili.
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Schubiger, Franz Xaver. « Grundlagen für die biologische Bekämpfung von 'Rumex obtusifolius' L. und R. 'crispus' L. mit 'Uromyces rumicis' (Schum.) Wint / ». [Zürich] : [s.n.], 1985. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=7888.
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Fassi-Fihri, Aliâa. « Influence du Ramadan et de l' horaire d' administration sur la pharmacocinétique de l' acide valproi͏̈que (Depakine(r)) ». Paris 5, 1996. http://www.theses.fr/1996PA05P014.
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Jelena, Nađpal. « Fitohemijski skrining i biološka aktivnost ekstrakata i tradicionalnih proizvoda od plodova divljih ruža (Rosa L.;Rosaceae) ». Phd thesis, Univerzitet u Novom Sadu, Prirodno-matematički fakultet u Novom Sadu, 2017. https://www.cris.uns.ac.rs/record.jsf?recordId=104437&source=NDLTD&language=en.
Texte intégralRésumé :
Cilj ove doktorske disertacije predstavljalo je ispitivanje fitohemijskog sastava i biološke aktivnosti vodenih i metanolnih ekstrakata svežih i suvih plodova, kao i voćne kaše i džema pripremljenih po tradicionalnoj recepturi od plodova šest samoniklih vrsta Rosa L.: R. canina, R. dumalis, R. dumetorum, R. tomentosa, R. arvensis, R. sempervirens. Ispitivanje fitohemijskog sastava obuhvatalo je LC -MS/MS analizu 64 odabrana fenolna jedinjenja, hinske kiseline (organske kiseline) kao i tri triterpenoida. Takođe, izvršeno je spektrofotometrijsko određivanje sadržaja ukupnih fenolnih i flavonoidnih jedinjenja, kao i vitamina C. Evaluacija biološke aktivnosti obuhvatala je in vitro ispitivanja antioksidantne i antiinflamatorne aktivnosti, kao i ispitivanje uticaja ekstrakata odabranih vrsta Rosa na aktivnost enzima acetilholinesteraze i rast tumorskih i netumorskih ćelija. Sumiranjem dobijenih rezultata može se zaključiti da sveži i suvi plodovi ispitivanih vrsta Rosa, kao i voćne kaše i džemovi predstavljaju značajan izvor vitamina C i fenolnih jedinjenja, sa elagnom kiselinom kao najzastupljenijom fenolnom komponentom. Takođe u pojedinim ekstraktima vrsta R. dumetorum i R. tomentosa detektovana je visoka koncentracija ursolne kiseline, dok je hinska kiselina prisutna u značajnoj koncentraciji u svim ispitivanim ekstraktima. Ekstrakti ispitivanih vrsta, izuzev vrste Rosa arvensis, pokazali su visok antioksidantni potencijal koji se ogleda u njihovoj sposobnosti neutralizacije nekoliko radikalskih vrsta, redukcionom potencijalu i sposobnosti inhibicije lipidne peroksidacije. Ispitivani ekstrakti ispoljili su umerenu antiinflamatornu aktivnost u pogledu inhibicije produkcije odabranih metabolita ciklooksigenaznog (12-HHT, TXB2, PGE 2) i 12-lipooksigenaznog (12-HETE) metaboličkog puta arahidonske kiseline, posebno prostaglandina E . Takođe, in vitro ispitivanjem uticaja ekstrakata odabranih vrsta Rosa na aktivnost acetilholinesteraze pokazana je umerena aktivnost. Vodeni ekstrakti i ekstrakti voćnih kaša vrsta R. canina, R. tomentosa i R. sempervirens pokazali su umereni inhibitorni potencijal prema rastu HeLa ćelijske linije, dok su ekstrakti vrste R. sempervirens pokazali aktivnost i prema HT-29 ćelijama. Dobijeni rezultati ukazuju na značajni potencijal plodova i tradicionalnih proizvoda ispitivanih vrsta Rosa za upotrebu u proizvodnji nutraceutika i funkcionalne hrane.The aim of presented doctoral thesis was investigation of phytochemical composition and biological activity of water and methanol extracts of fresh and air- dried rose hips, as well as purée and jam made according to traditional recipe of hips of six wild growing Rosa L. species: R. canina, R. dumalis, R. dumetorum, R. tomentosa, R. arvensis, and R. sempervirens. Examination of phytochemical composition included LC-MS/MS analysis of 64 selected phenolic compounds, quinic acid (organic acid) and three triterpenoids. Also, total phenolic and flavonoid contents, as well as vitamin C contents were determined spectrophotometrically. Biological activity evaluation of extracts of six Rosa species included in vitro investigation of antioxidant, anti- inflammatory, anti-acetylcholinesterase and cytotoxic activity. According to obtained results, fresh and air-dried rose hips, as well as their preserves present valuable source of vitamin C and phenolic compounds, especially ellagic acid, which was the most abundant examined phenolic compound. Furthermore, high concentration of ursolic acid was detected in some Rosa tomentosa and R. rumetorum extracts, while notable concentration of quinic acid was present in all examined extracts. Extracts of all examined species, apart from Rosa arvensis, showed considerable antioxidant activity in terms of radical scavenging ability, reduction potential and inhibition of lipid peroxidation. Moreover, extracts exhibited moderate anti- inflammatory activity by means of inhibition of the main arachidonic acid metabolites formed incyclooxygenase-1 (12-HHT, TXB2, PGE 2 ) and 12-lipoxygenase (12-HETE) pathway, especially prostaglandin E2 . Also, investigation of anti- cetylcholinesterase activity revealed moderate activity of extracts of all examined species. In addition, predominantly water extracts of fresh andair-dried rose hips, as well as purée of R. canina, R. tomentosa and R. sempervirens showed inhibitory activity toward HeLa, while R.sempervirens extracts also inhibited HT-29 cell growth. Presented results indicate significant potential of examined rose hips and their preserves for use as nutraceuticals and functional food.
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Sichhart, Yvonne. « Gene, Enzyme und Produkte der Calysteginbildung in Calystegia sepium (L.) R. Br ». [S.l. : s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=970636415.
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Sotomayor, Castillo Teresa, Chu Carmen Maticorena, Chávez Isaac Moses et Mogollón Danilo Valdiviezo. « Plan estratégico de la Empresa Constructora San Jorge E. I. R. L ». Master's thesis, Pontificia Universidad Católica del Perú, 2015. http://tesis.pucp.edu.pe/repositorio/handle/123456789/8852.
Texte intégralRésumé :
xiii, 149 h. : il. ; 30 cm.En el presente trabajo de tesis, se realiza un planeamiento estratégico para la Constructora San Jorge E. I. R. L., en el que se analiza la situación actual de la empresa, y se plantea un horizonte de tiempo de 10 años para su ejecución, implementación y puesta en marcha a fin de llegar a una situación futura deseada. Este plan estratégico se ha iniciado con el establecimiento de la visión, misión, valores y código de ética de la constructora. Luego se ha realizado el análisis del entorno para Constructora San Jorge E. I. R. L., del cual se obtuvieron siete oportunidades y ocho amenazas. Del análisis del sector construcción y de la competencia, se obtuvieron diez factores claves de éxito. Asimismo, del análisis interno de la constructora se obtuvieron ocho fortalezas y seis debilidades. Estos tres análisis han permitido conocer y comprender el entorno de la Constructora San Jorge E. I. R. L., y plantear nueve estrategias: (a) Establecer alianzas estratégicas con los actuales y nuevos proveedores de insumos y materiales de construcción, (b) Desarrollar relaciones orientadas a la obtención de mejores condiciones financieras con los bancos privados, (c) Desarrollar el talento profesional del personal, (d) Ejecutar proyectos de inversión privada, (e) Penetrar en mercados nacionales, (f) Desarrollar un programa de optimización de gastos e inversión por obra, (g) Desarrollar alianzas estratégicas con empresas extranjeras del mismo rubro para tener mayor competitividad en el país, (h) Implementar certificaciones de calidad para poder competir con empresas extranjeras, y (i) Implementar sistemas de contingencia frente a la problemática social del país. Estas estrategias permitirán llegar a la visión de la Constructora San Jorge E. I. R. L. a través de seis objetivos de largo plazo: (a) al 2025, incrementar las ventas a S/. 30‟000,000 de soles. En el año 2014, las ventas totalizaron S/. 15‟000,000 de soles y el incremento promedio de ventas de los tres últimos años fue de 73%; (b) al 2025, obtener una utilidad sobre ventas de 10%. En el año 2014, la utilidad sobre ventas fue de 3.4%; (c) al 2025, formar parte del ranking de las 20 mayores empresas constructoras del Perú, según América Economía; (d) al 2025, contar con una certificación ISO 9001 y/o OHSAS 18001; (e) al 2025, desarrollar cinco acciones en beneficio de la comunidad vinculada, promoviendo el cuidado del medio ambiente, dado que a la fecha la constructora no cuenta con un plan de responsabilidad social; y; (f) al 2025, desarrollar y poner en marcha al menos tres nuevas mejoras tecnológicas que enriquezcan la eficiencia de los procesos y de los recursos. Actualmente no se cuentan con mejoras tecnológicas debido a la carencia de un área de Innovación & Desarrollo. También se han establecido objetivos de corto plazo, los cuales permitirán realizar la revisión, evaluación, y control de los resultados. El entorno es favorable para Constructora San Jorge E. I. R. L.; sin embargo, en su organización interna resulta necesario contar con áreas importantes, como Recursos Humanos, Marketing, Finanzas, e Investigación y Desarrollo; además de contar con un sistema informático integral que permita mejorar su gestión. Para los objetivos de corto plazo, se asignaron los recursos necesarios para el cumplimiento de los mismos, así como también las políticas para cada una de las estrategias retenidas. Se plantea también una nueva estructura organizacional con la inclusión de áreas necesarias para la mejora de la constructora. Finalmente, en el proceso estratégico, la etapa de evaluación y control se realizará a través del Tablero de Control Balanceado (Balanced Scorecard)
In this thesis work, we make a strategic planning for Constructora San Jorge E.I.R.L., in which the current situation of the company is analyzed and we propond a horizon of time of ten years for the execution, implementation and setting up in order to reach a desired future situation. This strategic plan has begun with the establishment of vision, mission, values and code of ethics of the enterprise. After we have made the analysis the of environment of the Constructora San Jorge E.I.R.L., in we obtained which seven oportunities and eight threats. Of the Analysis of the construction sector and competition, we obtained ten key success factors. Also, of the internal analysis of the construction we obtained eight strengths and six weaknesses. These three tests have allowed us to know and understand the environment of Constructora San Jorge E.I.R.L., and raise nine strategies: (a) Establish strategic alliances with current and new suppliers of equipment and materials, (b) Develop oriented relationships at achieving better conditions financing with private banks, (c) develop the professional talent of staff, (d) Run private investment projects, (e) Penetrating national markets, (f) Develop an optimization program expenditures an investment by work, (g) Develop strategic alliances with foreign companies in the same industry to be more competitive in the country, (h) Implement quality certifications to compete with foreign companies, and (i) Implement contingency systems taked social problems of the country. These strategies will allowed reach the vision of Constructora San Jorge E.I.R.L. through six long-term objectives: (a) By 2025, increase sales to S/. 30‟000,000 soles. In 2014, sales totaled S/. 15‟000,000 soles and the average increase in sales of the last three years was 73%, (b) In 2025, get a return on sales of 10%. In 2014, the return on sales was 3.4%, (c) By 2025, part of the ranking of the 20 largest construction companies in Peru, according to America Economic (d) By 2025, have an ISO 9001 certification and / or OHSAS 18001, (e) By 2025, develop five actions to benefit the associated community, promoting environmental stewardship, since the date the builder does not have a social responsibility plan, (f) By 2025, develop and launch at least three new technological improvements that enhance the efficiency of processes and resources. Currently they not have technological improvements due to the lack of an area of Innovation & Development. We have also short-term objectives, which will allow us to make the review, evaluation, and control of the results. The environment is favorable for Constructora San Jorge E.I.R.L.; However, in its internal organization is important canting with areas such as Human Resources, Marketing, Finance, and Research and Development; in addition to a integral computerized system to improve its management. For short-term goals the resources necessary to fulfill them were assigned, as well as policies for each one of the retained strategies. A new organizational structure also arises with the inclusion of necessary areas for improvement of the enterprise. Finally, in the strategic process, the evaluation stage and control will be make through the Balanced Scorecard (Balanced Scorecard)
Tesis
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Paula, Joelma Abadia Marciano de. « Fitoquímica e atividades biológicas de pimenta pseudocaryophyllus (Gomes) L. R. Landrum (Myrtaceae) ». Universidade Federal de Goiás, 2011. http://repositorio.bc.ufg.br/tede/handle/tede/4339.
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Fundação de Amparo à Pesquisa do Estado de Goiás - FAPEG
The purpose of this work is to carry out the phytochemical study and evaluate biological activities of the essential oil and extracts of the Pimenta pseudocaryophyllus (Gomes) L.R. Landrum (Myrtaceae) leaves. Chapter 1 provides a review of the main botanical aspects of the genus Pimenta, its chemical composition and pharmacological potential. Chapter 2 describes the occurrence of infraspecific variability in P. pseudocaryophyllus. For this the essential oils from 12 specimens of P. pseudocaryophyllus that occur naturally in three different locations of the Brazilian Cerrado underwent a qualitative and quantitative analysis by gas chromatography-mass spectrometry (GC/MS). The multivariate statistical analysis identified three chemotypes of P. pseudocaryophyllus, characterized by the predominance of citral, (E)-caryophyllene and (E)-methyl isoeugenol constituents. Chapter 3 presents the phytochemical assessment of the hexane, dichloromethane, ethyl acetate and aqueous fractions obtained from the crude ethanol extract of P. pseudocaryophyllus leaves. Chromatographic and spectrophotometric (1H and 13C) methods enabled the isolation and identification of lupeol, α-and -amyrin, oleanolic, ursolic and betulinic acids, quercetin, quercitrin, isoquercitrin, afzelin, avicularin, guaijaverin, catechin, ellagic acid and gallic acid. Chapter 4 assesses the antimicrobial activity of the ethanol extracts, fractions (hexane, dichloromethane, ethyl acetate and aqueous), essential oils and isolated compounds of citral (CQ) and (E)-methyl isoeugenol (MQ) chemotypes of P. pseudocaryophyllus. The broth microdilution test was applied to determine the minimum inhibitory concentration (MIC) against strains of Gram(+) and Gram(-) bacteria, and of Candida and Cryptococcus spp fungi. The CQ and MQ dichloromethane fraction, CQ ethyl acetate fraction, and CQ essential oil were the most active (MIC = 62.5 to 500 mg / mL) against Gram(+). The oleanolic acid proved to also be responsible for this action. The CQ and MQ extracts of P. pseudocaryophyllus were active (MIC = 7.8 to 500 mg / mL) against most strains of Candida spp and Cryptococcus spp, where gallic acid, ellagic acid and quercitrin contributed to this action. The data obtained indicate the antimicrobial potential of CQ and MQ P. pseudocaryophyllus against some infectious diseases. Chapter 5 describes the antinociceptive activity, in mice, of CQ and MQ ethanol extracts, CQ fractions and CQ essential oil, and the anti-inflammatory activity of CQ crude ethanol extract of P. pseudocaryophyllus. The abdominal writhing test induced by intraperitoneal administration (ip) of acetic acid (1.2% v / v) and the ear edema test induced by croton oil (2.5% V/V) were performed. The CQ crude ethanol extract (2000, 1000 and 500 mg/kg, po) showed a dose-dependent antinociceptive effect. Among the fractions, only the aqueous fraction was not active. The CQ essential oil (60, 200 and 600 mg / kg, po) presented significant antinociceptive activity, probably because of its high citral concentration. Pretreatment with CQ crude ethanol extract (2000, 1000 and 500 mg / kg) reduced edema by 14.3 ± 0.4 mg (control) to 10.9 ± 0.5, 11.3 ± 0, 4, 10.5 ± 0.5 mg, respectively. The analgesic effect may be related to an anti-inflammatory action observed in the ear edema test.
O presente trabalho teve como objetivos realizar o estudo fitoquímico e avaliar atividades biológicas do óleo essencial e de extratos da folha de Pimenta pseudocaryophyllus (Gomes) L. R. Landrum (Myrtaceae). O Capítulo 1 traz uma revisão bibliográfica do gênero Pimenta onde são abordados os principais aspectos botânicos, a composição química e o potencial farmacológico. O Capítulo 2 descreve a ocorrência de variabilidade infraespecífica em P. pseudocaryophyllus. Para tanto, foi realizada a análise qualitativa e quantitativa, por cromatografia gasosa acoplada a espectrometria de massas (CG/EM), do óleo essencial das folhas de 12 espécimes de P. pseudocaryophyllus que ocorrem naturalmente em três diferentes localidades do Cerrado brasileiro. A análise estatística multivariada dos dados identificou três quimiotipos de P. pseudocaryophyllus, caracterizados pela predominância dos constituintes citral, (E)-cariofileno e (E)-metilisoeugenol. O Capítulo 3 apresenta os resultados da avaliação fitoquímica das frações hexano, diclorometano, acetato de etila e aquosa obtidas a partir do extrato etanólico bruto das folhas de P. pseudocaryophyllus. A partir da utilização de técnicas cromatográficas e espectrofotométricas (RMN 1H e 13C) foi possível isolar e identificar os triterpenos pentacíclicos lupeol, α- e -amirina, os ácidos oleanólico, ursólico e betulínico, os flavonóides quercetina, quercitrina, isoquercitrina, afzelina, avicularina, guaijaverina e catequina, e os ácidos gálico e elágico. O Capítulo 4 expõe a avaliação da atividade antimicrobiana dos extratos etanólicos brutos, frações (hexano, diclorometano, acetato de etila e aquosa), óleos essenciais e substâncias semipurificadas de P. pseudocaryophyllus quimiotipos citral (QC) e (E)- metilisoeugenol (QM). Foi utilizado o teste da microdiluição em caldo, que permitiu determinar a Concentração Inibitória Mínima (CIM) frente a cepas de bactérias Gram(+), Gram(-) e fungos Candida spp. e Cryptococcus spp. As frações diclorometano (QC e QM), acetato de etila (QC) e o óleo essencial do quimiotipo citral foram os mais ativos (CIM = 62,5-500 μg/mL) frente as bactérias Gram(+), o ácido oleanólico mostrou ser um dos responsáveis por essa ação. O QC e QM foram ativos (CIM = 7,8 – 500 μg/mL) frente à maioria das cepas fúngicas, sendo que ácido gálico, ácido elágico e quercitrina contribuíram para essa ação. Os dados obtidos indicaram que P. pseudocaryophyllus QC e QM apresentam potencial antimicrobiano. O Capítulo 5 descreve a avaliação da atividade antinociceptiva, em camundongos, dos extratos etanólicos brutos (QC e QM), frações e óleo essencial (QC) de P. pseudocaryophyllus e a atividade anti-inflamatória do extrato etanólico bruto (QC) de P. pseudocaryophyllus. Foram utilizados os testes das contorções abdominais induzidas pela administração intra-peritonial (i.p.) de ácido acético (1,2%, v/v) e do edema de orelha induzido pelo óleo de cróton (2,5%, V/V) em camundongos. O extrato etanólico bruto QC (2000, 1000 e 500 mg/kg, v.o.) demonstrou efeito antinociceptivo dose-dependente. Dentre as frações, apenas a aquosa não foi ativa. O óleo essencial QC (60, 200 e 600 mg/kg, v.o.) demonstrou significativa atividade antinociceptiva, provavelmente por causa do seu elevado teor em citral. O pré-tratamento com o extrato etanólico bruto QC nas dose 2000, 1000 e 500 mg/kg reduziu o edema de 14,3±0,4 mg (controle) para 10,9±0,5; 11,3±0,4; 10,5±0,5 mg, respectivamente. A ação analgésica pode estar relacionada a uma ação anti-inflamatória, observada no teste de edema de orelha.
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Pontes, Ismael. « A vocalização do /r/ pos-vocalico oriundo de /l/ no dialeto caipira ». reponame:Repositório Institucional da UFPR, 2010. http://hdl.handle.net/1884/24552.
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Coviello, Anna Chiara. « Esistenza del minimo globale per certi tipi di problemi vincolati in R^n ». Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2010. http://amslaurea.unibo.it/1558/.
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Peng, Shuang. « Investigation of the mechanism of L-asparaginase-induced acute pancreatitis ». Thesis, Cardiff University, 2017. http://orca.cf.ac.uk/103362/.
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Intracellular Ca2+ and adenosine triphosphate (ATP) are the key elements needed for stimulant-evoked exocytotic enzyme secretion from pancreatic acinar cells. Physiological Ca2+ signals consist of repetitive spikes confined to the secretory granule region, which stimulate ATP production; whereas sustained global cytosolic Ca2+ elevations - toxic Ca2+ signals decrease ATP levels and cause necrosis leading to the inflammation of the pancreas - acute pancreatitis (AP), a life-threatening disease currently without specific therapy. The work presented in this thesis focuses on the mechanisms underlying the development of pancreatitis evoked by L-asparaginase and the potential ways to intervene asparaginase-associated pancreatitis (AAP). Asparaginase is an essential element of the chemotherapy regimen in the successful treatment of acute lymphoblastic leukaemia (ALL), the most common childhood cancer. But asparaginase treatment can lead to AAP, which is a side-effect of ALL treatment occurring in about 5–10% of cases. Following AP, further treatment with asparaginase is withheld to prevent recurrence of AP; however, withholding scheduled asparaginase is associated with a potential increase in ALL relapse. Understanding the pathogenesis of AAP could lead to effective therapies for this complication, potentially reducing toxicity and allowing re-exposure to continue treatment with asparaginase.
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Adamiok, Anna. « Le microRNA miR-449 contrôle le développement des cellules multiciliées dans l' épithélium mucociliaire de l' amphibien Xenopus laevis en agissant sur des multiples gènes cibles ». Thesis, Aix-Marseille, 2014. http://www.theses.fr/2014AIXM4075/document.
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Le processus de formation des cils mobiles multiples (multiciliogénèse) est composé de nombreuses étapes. Récemment, nous avons démontré que les microARNs de la famille miR-449 contrôlent plusieurs de ces étapes. Au cours de mon travail, je me suis concentré sur le rôle joué par miR-449 dans deux aspects du développement de l'épithélium multicilié. Dans les cellules multiciliées, un réseau dense d'actine sous-jacent l'aspect apicale de la membrane cellulaire (coiffe d'actine) est nécessaire pour l'ancrage des multiples corps basaux, et donc pour une ciliogenèse approprié. Dans le cadre de mon travail, j'ai participé à l' identification de la petite GTPase R-Ras comme une des véritables cibles de miR-449. J'ai démontré que la réorganisation de la coiffe d'actine et l'ensemble du processus de multiciliogénèse étaient compromis lorsque l'ARN messager de R-Ras se trouve protégé de la liaison avec miR-449. J'ai aussi contribué à identifier une nouvelle cible de miR-449, le gène Steel, qui code pour le ligand du récepteur transmembranaire à tyrosine-kinase KIT. La repression de Steel par miR449 est impliquée dans le processus par lequel les cellules multiciliées atteignent leur position finale dans l'épiderme embryonnaire de Xenopus. STEEL, qui agit probablement comme une molécule de guidage pour les cellules multiciliées qui expriment KIT, doit être réprimé par miR-449 dans ces mêmes cellules en cours de migration pour assurer leur deplacement directionnel approprié. En conclusion, mon travail a contribué à élucider le rôle complexe joué par le miARN miR-449 dans le processus de multiciliogénèse chez les vertébrésThe process of multiple motile cilia formation (multiciliogenesis) is composed of many different steps. Recently, we demonstrated that microRNAs of the miR-449 family control several of these steps. During my work, I focused on the role played by miR-449 in two aspects of the development of the mucociliary epithelium. In multiciliated cells, a dense actin network underlying the apical aspect of the cell membrane (actin cap) is required for the anchoring of the multiple basal bodies, and therefore for proper ciliogenesis. Small GTPases play important role in the formation of the actin cap. In the course of my work, I took part in the identification of transcripts coding the small GTPase R-Ras as bona fide targets of miR-449. I demonstrated that apical and subapical actin network reorganization and multiciliogenesis were impaired when R-Ras mRNA was protected from miR-449 binding. Moreover, the actin cap formation and multiciliogenesis were rescued when the translation of protected R-Ras transcripts was prevented. I also contributed to the finding that a new miR-449 target, the KIT receptor tyrosin kinase ligand STEEL, is involved in the process through which the multiciliated cells reach their final position within the developing frog epidermis. STEEL, which likely acts as a guidance molecule for the KIT-expressing multiciliated cells, needs to be repressed by miR-449 within the migrating cells to ensure their proper directional migration. Altogether, my work contributed to elucidate the complex role played by the miR-449 miRNA in the process of vertebrate multiciliogenesis
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Ralph, Thomas R. « The electroreduction of L-cystine hydrochloride to L-cysteine hydochloride ». Thesis, University of Strathclyde, 1991. http://digitool.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=30707.
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The electrosynthesis of L-cysteine hydrochloride is examined at a range of cathodes. Kinetic studies are possible only at mercury and lead. Both voltammetry and coulometry studies are reported. Based essentially upon electrochemical reaction orders of +1 for L-cystine hydrochloride and protons, and high Tafel slopes of ca. 180 mV/decade, attributed to disulphide adsorption, the mechanism of reduction is, as far as can be ascertained, equivalent at the metals. The RDS is transfer of the first electron to the disulphide molecule. For high disulphide concentrations kf is ca. 7 x 10-1 0 m s - 1 at mercury and ca. 2.5 x 10-1 1 m s-1 at lead. Several techniques yielded values for the diffusion coefficient of L-cystine hydrochloride, the relative merits of which are discussed. Constant current electrolysis is performed in a parallel plate reactor operating in the batch recycle mode and the reactant concentration monitored with time. At mercury plated copper and lead cathodes the reactant depletion is predicted by mathematical models describing a reaction which is initially under charge transfer control followed by an instantaneous change to pure mass transport control. The models do not predict the reactant depletion at the other cathodes, because of an extensive mixed charge transfer-mass transport controlled region. To evaluate the models the average mass transport coefficient in the reactor is determined using the diffusion limited current technique. Additionally, using this technique, the enhancement in mass transport produced by various turbulence promoters is correlated with a specific geometrical characteristic of the promoters. Parametric studies of current density and catholyte flowrate identified the optimum electrosynthesis conditions. High catholyte flowrates and the use of turbulence promoters are particularly important to the process economics. At 500 A m-2 mercury plated copper and lead are the most efficient cathodes but at 2,000 A m-2 titanium compares favourably with these metals. The durability of all three cathodes is, however, inadequate for an industrial process.
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Busse, Beate. « R. L. Stine Der Stephen King für Kinder Ausgewählte Untersuchungen zu seinen Gruselserien / ». [S.l. : s.n.], 2003. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB11675507.
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Sykes, Lucy Helen. « The role of L-type voltage gated calcium channels and psychiatric risk gene CACNA1C in associative learning ». Thesis, Cardiff University, 2016. http://orca.cf.ac.uk/98747/.
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CACNA1C codes for the alpha-1 subunit of Cav1.2 L-type voltage gated calcium channels (LVGCCs). Variation in CACNA1C has been reliably implicated in psychiatric illness, including schizophrenia and bipolar disorder. Analyses have indicated a convergence of genetic risk for schizophrenia on abnormalities in the synapse and in behaviours including associative learning. LVGCCs play a role in synaptic plasticity and learning, partly through regulation of gene transcription. Their role in specific aspects of associative learning that are relevant for symptoms of psychiatric illness is yet to be fully elucidated. A hippocampal-dependent fear conditioning paradigm was used to determine the role of Cacna1c and LVGCCs in specific aspects of associative learning in rats. Studies measured the activity-regulated expression of Cacna1c and the effect of inhibition of LVGCCs. A genetic Cacna1c knockdown rat model was used to investigate the effects of reduced expression on behaviour and the expression of brain derived neurotrophic factor (BDNF). This model was additionally tested on reward-based reversal-learning. Analyses were translated to humans, to assess whether disease relevant variation in CACNA1C was associated with similar deficits in reversal learning and expression. Inhibition of LVGCCs affected the consolidation, extinction and latent inhibition of contextual fear memory, whereas reduced expression of Cacan1c had a selective effect on latent inhibition. There were no effects on the acquisition of reward associations, but reversal learning was impaired. Similar deficits in reversal learning were associated with disease relevant variation in CACNA1C in humans. Reduced CACNA1C expression was found to be associated with changes in the expression of BDNF in both rats and humans. Results indicate a role for Cacna1c and LVGCCs in the appropriate formation and update of aversive and reward associations. Impairments in these processes can underlie specific symptoms of disease including emotion dysregulation and delusions. The cross-species effects on BDNF require further investigation.
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Caissie, Nadine. « Inventaire et productivité de Prunus virginiana L., Sambucus canadensis L., Viburnum trilobum Marsh., Vaccinium vitis-idaea L. et Rubus chamaemorus L. dans la Péninsule acadienne avec une étude des populations de R. chamaemorus L ». Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ33860.pdf.
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Brand, Kristin [Verfasser], L. A. [Akademischer Betreuer] Wessjohann et R. [Akademischer Betreuer] Mahrwald. « Chalcogen based organocatalysts in transesterification / Kristin Brand. Betreuer : L. A. Wessjohann ; R. Mahrwald ». Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2015. http://d-nb.info/1072072793/34.
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Tra, Yolande. « A study of nonparametric estimation of location using L-, M- and R-estimators ». Virtual Press, 1994. http://liblink.bsu.edu/uhtbin/catkey/917018.
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Nonparametric procedures use weak assumptions such as continuity of the distribution so that they are applicable to a large class F of underlying distributions. Statistics that are distribution-free over F may be constructed to be estimators of location. Such estimators are derived from rank tests called R-estimators. They are robust estimators. The concept of robust estimation is based on a neighborhood of parametric models called "gross error models". The M-estimator, which is a maximum likelihood type estimator, arose from such investigations using the normal distribution. A third big class of estimators is the class of linear combinations of order statistics called L-estimators. They are constructed as an average of quantiles. Examples are the sample mean and the sample median.In this thesis, some definitions and results involving these three basic classes of estimates are provided. For each class, an example of a robust estimator is presented. Numerical values are given to assess the robustness of each estimator in terms of breakdown point and gross error sensitivity. Further, the U-statistics which are unbiased estimators of location parameters, are used to obtain asymptotically efficient R-estimates.Department of Mathematical Sciences
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Padi, Francis Kwame. « Genetic analyses of adaptive traits in pearl millet (Pennisetum glaucum (L.) R. Br.) ». Thesis, University of East Anglia, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251634.
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Houen, Alex. « Exploding literature : the writing of terrorism from R. L. Stevenson to Walter Abish ». Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.428724.
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BELUS, JEAN-FRANCOIS. « L'osteo-integration en o. R. L. : applications en chirurgie otologique et maxillo-faciale ». Aix-Marseille 2, 1994. http://www.theses.fr/1994AIX20715.
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Shinohara, Y. « Perceptual training of English /r/ and /l/ for Japanese adults, adolescents and children ». Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1421176/.
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Although phoneme perception and production in second-language (L2) learners has been the focus of much research over the past few decades, the learning mechanisms and the factors that influence them are still far from understood. The purpose of this PhD research is to cast some light on the mechanisms underlying the learning of L2 phonemes and the effects of age. Japanese speakers who have problems in perception and production of the English /r/-/l/ contrast participated in three perceptual training studies. The first study examined whether Japanese adults can improve their perception and production with identification and discrimination training. The results demonstrated that both identification and discrimination training methods improved their perception and production of the English /r/-/l/ contrast, but the combination of two different training methods did not have additive effects. The second study investigated how age affects the learning of the English /r/-/l/ contrast at phonetic and phonological levels of perception. The results demonstrated that Japanese adults are disadvantaged in improving their phonetic perception of the English /r/-/l/ contrast due to their relatively fossilised brain plasticity and their developed L1 phonetic units. On the other hand, younger learners are able to improve both phonetic and phonological perception of the contrast. This may be attributed to their greater brain plasticity and less interference from undeveloped L1 phonetic categories. Finally, the third study examined how Japanese speakers improve production of English /r/ and /l/ through perceptual training, and found that perceptual training transferred to production ability in both identifiability and acoustic realisations. The improvement in production seemed to be attributable to perceptual learning. There may be a common underlying ability for perception and production, although the acoustic dimensions which link the two may be different between individuals. The theoretical implications for understanding learning mechanisms and age effects are discussed.
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Melotto, Raoul <1975>. « L'ultima lingua. Studio sulla poesia francese di R. M. Rilke ». Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2007. http://amsdottorato.unibo.it/43/.
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