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Thèses sur le sujet « LC-MS (Liquid Chromatography-Mass Spectrometry) »

Auteur : Grafiati

Publié le 7 juin 2025

Mis à jour le 2 août 2025

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1

Crnogorac, Goranka. "Analysis of dithiocarbamate fungicide residues by liquid chromatography, mass spectrometry and isotope ratio mass spectrometry." Aachen Shaker, 2008. http://d-nb.info/993691447/04.

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Törnvall, Erica. "Determination of testosterone esters in serum by liquid chromatography – tandem mass spectrometry (LC-MS-MS)." Thesis, Linköping University, Organic Analytical Chemistry, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-58045.

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<p>Anabolic androgenic steroids are testosterone and its derivates. Testosterone is the most important naturally existing sex hormone for men and is used for its anabolic effects providing increased muscle mass. Testosterone is taken orally or by intramuscular injection in its ester form and are available illegally in different forms of esters. Anabolic androgenic steroids are today analyzed only in urine. To differentiate between the human natural testosterone and exogenous supply the quote natural testosterone and epitestosterone is used. Detection of testosterone esters in serum is an unmis

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Cerruti, Laura F. "Evaluation of a particle beam interface for LC/MS." Thesis, Virginia Tech, 1989. http://hdl.handle.net/10919/44624.

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<p>The performance of a Hewlett Packard Particle Beam LC/MS interface is evaluated using EPA appendix VIII and IX compounds. The behavior of these priority pollutants in the interface could determine its feasibility as a future EPA certified technique.</p> <p>The evaluation process consists of studies to determine minimum detectable quantities (MDQ), linear response, and band broadening contributions. The MDQ's of the analytes in electron impact and chemical ionization modes are extrapolated from experimental signal to noise data. The linearity study involves ten compounds analyzed

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Nicolaou, Anna, Mojgan Masoodi, and Adnan A. Mir. "Lipidomic analysis of prostanoids by liquid chromatography-electrospray tandem mass spectrometry." Springer, 2009. http://hdl.handle.net/10454/4575.

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no<br>Lipidomics aim to generate qualitative and quantitative information on different classes of lipids and their species, and when applied in conjunction with proteomic and genomic assays, facilitate the comprehensive study of lipid metabolism in cellular, organ or body systems. Advances in mass spectrometry have underpinned the expansion of lipidomic methodologies. Prostanoids are potent autacoids present in a plethora of cellular systems, known best for their intimate role in inflammation. Electrospray ionisation (ESI) allows the efficient ionisation of prostanoids in aqueous systems. ESI

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Nascimento, DemÃtrius Fernandes do. "Nimodipine determination in human plasma by high-performance liquid chromatography coupled to tandem mass spectrometry (HPLC-MS-MS)." Universidade Federal do CearÃ, 2005. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=31.

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Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico<br>A rapid, specific and highly sensitive liquid chromatography-tandem mass spectrometry method was developed to determine nimodipine in human plasma using dibucaine as the internal standard (IS) is described. The analyte (m/z 418,6 > 342,6) and IS (m/z 344,2 > 271,0) were extracted from plasma samples by liquid-liquid extraction using hexane-ethyl acetate (1:1v/v). Chromatography was performed on a VarianÂ Polaris C18 analytical column (3 micrometer, 50 x 2,0 mm) and pre-column SecurityguardTM C18 (4,0 x 3,0 mm). The phase mobile c

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Rousu, T. (Timo). "Liquid chromatography–mass spectrometry in drug metabolism studies." Doctoral thesis, Oulun yliopisto, 2012. http://urn.fi/urn:isbn:9789514298172.

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Abstract Drug metabolite profiling and identification studies are nowadays regularly conducted with liquid chromatography (LC) coupled with mass spectrometry (MS) as an analytical tool. The speed, selectivity and sensitivity of modern LC–MS instruments have been significantly increased in recent years. Especially the use of ultra-high-performance LC (UHPLC) in combination with a modern high-resolution MS instrument offers high full scan detection sensitivity, mass accuracy and the detection of both expected and unexpected metabolites in a single LC–MS run. The present study showed that no sing

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Zhou, Bin. "Computational Analysis of LC-MS/MS Data for Metabolite Identification." Thesis, Virginia Tech, 2011. http://hdl.handle.net/10919/36109.

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Metabolomics aims at the detection and quantitation of metabolites within a biological system. As the most direct representation of phenotypic changes, metabolomics is an important component in system biology research. Recent development on high-resolution, high-accuracy mass spectrometers enables the simultaneous study of hundreds or even thousands of metabolites in one experiment. Liquid chromatography-mass spectrometry (LC-MS) is a commonly used instrument for metabolomic studies due to its high sensitivity and broad coverage of metabolome. However, the identification of metabolites remains

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Shi, Wunan. "High-Throughput De Novo Sequencing of Transfer RNAs Using Liquid Chromatography-Tandem Mass Spectrometry." University of Cincinnati / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1378197247.

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Tarr, Matthew Aaron. "Characterization and optimization of sample introduction systems for ICP-AES, ICP-MS, and LC-MS." Diss., Georgia Institute of Technology, 1992. http://hdl.handle.net/1853/27987.

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Allegood, Jeremy Chadwick. "Application of liquid chromatography tandem mass spectrometry for the separation and quantitative analysis of sphingolipids." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/42691.

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Sphingolipids are a highly diverse category of compounds that serve not only as components of biologic structures but also as regulators of numerous cell functions. Because so many of the structural features of sphingolipids influence their biological activity, there is a need for comprehensive methods for quantitation of as many individual subspecies as possible. This dissertation describes methods that have been developed and validated for the extraction, liquid chromatographic separation, identification and quantitation of sphingolipids by electrospray ionization (ESI), tandem mass spectr

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Lucas, Natasha. "The Analysis of Recreational Drugs in Biological Specimens Using Liquid Chromatography Mass Spectrometry." The University of Waikato, 2008. http://hdl.handle.net/10289/2471.

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In the last few years, the prevalence of legal party pills in New Zealand has risen dramatically. These pills contain new piperazine designer drugs, two of the more common being 1-benzylpiperazine (BZP) and m-trifluoromethylphenylpiperazine (TFMPP). This thesis describes an optimised LC-MS/MS method for the detection of BZP and TFMPP in whole blood, using an automated solid phase extraction (SPE) for sample clean-up. The method was validated on three different days using five replicate samples each day. The standard curve was linear from 7 - 7000 ng/mL for BZP and 10 - 10,000 ng/mL for TFMPP,

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Thenstedt, Niklas. "Detektion av hydrolyserad β-laktamantibiotika i plasma med Matrix-Assisted Laser Desorption Ionization – Time of Flight Mass Spectrometry och Liquid Chromatography tandem Mass Spectrometry". Thesis, Örebro universitet, Institutionen för hälsovetenskaper, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-84594.

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Introduktion Antibiotikaresistens är ett globalt växande problem. Till gruppen β-laktamantibiotika hör piperacillin-tazobaktam och cefotaxim som båda verkar genom att försvaga cellväggen med kovalenta bindningar till peptidoglykanlagret som lyserar cellen. E. coli och K. pneumoniae tillhör gruppen Enterobacteriaceae, som är en del av den humana tarmfloran och ofta förekommande vid urinvägsinfektion och sepsis. Utvidgat Spektrum β-Laktamas (ESBL) är ett enzym som finns hos Enterobacteriaceae och som hydrolyserar β-laktamantibiotika. Matrix assisted laser desorption ionization time of flight mas

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Tolonen, A. (Ari). "Analysis of secondary metabolites in plant and cell culture tissue of Hypericum perforatum L and Rhodiola rosea L." Doctoral thesis, University of Oulu, 2003. http://urn.fi/urn:isbn:9514271610.

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Abstract Sensitive chromatographic methods were developed for the quantitative analysis of secondary metabolites in Hypericum perforatum (St. John's wort) and Rhodiola rosea (Golden root, rose root) extracts. Sample preparation methods were developed for plant, cell culture and biotransformation suspension matrixes. High performance liquid chromatography (HPLC) was used for the separation of analytes, and chromatographic data was acquired using photodiode array (PDA) detection or atmospheric pressure ionization mass spectrometry (API-MS). Ionization efficiencies with electrospray ionization (E

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Nezami, Ranjbar Mohammad Rasoul. "Novel Preprocessing and Normalization Methods for Analysis of GC/LC-MS Data." Diss., Virginia Tech, 2015. http://hdl.handle.net/10919/73499.

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We introduce new methods for preprocessing and normalization of data acquired by gas/liquid chromatography coupled with mass spectrometry (GC/LC-MS). Normalization is desired prior to subsequent statistical analysis to adjust variabilities in ion intensities that are not caused by biological differences. There are different sources of experimental bias including variabilities in sample collection, sample storage, poor experimental design, noise, etc. Also, instrument variability in experiments involving a large number of runs leads to a significant drift in intensity measurements. We propose n

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McKinney, Mariah, Courtney Gail Troglin, Jessica Brooke Bouldin, Shannon Schreiner, Stacy D. Brown, and Brooks B. Pond. "Pharmacokinetics of Synthetic Cathinones Found in “Bath Salts” in Mouse Brain and Plasma Using High Pressure Liquid Chromatography – Tandem Mass Spectrometry." Digital Commons @ East Tennessee State University, 2021. https://dc.etsu.edu/asrf/2021/presentations/15.

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Approximately 10 years ago, “bath salts” were popularized as legal alternatives to the psychostimulants cocaine and the amphetamines, circumventing legislation with packages marked, “not for human consumption.” These products contained synthetic cathinones including 3,4-methylenedioxypyrovalerone (MDPV), 4-methylmethcathinone (mephedrone), and 3,4-methylenedioxymethcathinone (methylone). The synthetic cathinones have similar pharmacology to controlled psychostimulants, increasing levels of dopamine (DA) in the synaptic cleft, while also exhibiting similar psychoactive effects such as increased

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CAMPISI, GIUSEPPE MATTEO. "DETERMINATION OF THE SPHINGOLIPID BIOSYNTHESIS INHIBITOR MYRIOCIN BY LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY (LC-MS/MS). PILOT APPLICATIONS IN BIOLOGICAL MODELS." Doctoral thesis, Università degli Studi di Milano, 2017. http://hdl.handle.net/2434/472570.

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Introduction. Myriocin (Myr) is an antifungal compound isolated in the 1972s from Myriococcum albomyces. Myr specifically inhibits serine palmitoyl transferase, the first enzyme involved in the de novo synthesis of Ceramide (Cer), which Intracellular accumulation yields inflammation and apoptosis. Targeting Cer biosynthesis, thus, may be a promising therapeutic treatment for all sphingolipid-related diseases. To test the efficacy of Myr as pharmacological tool able to drive the clinical outcome and rationalize the dose-effect relationship, Myr levels need to be accurately measured in minute am

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Halquist, Matthew. "Quantitative Analysis of Multiple Charged Large Molecules in Human or Rat Plasma Using Liquid Chromatography Tandem Mass Spectrometry." VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/2702.

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Immunoassays have traditionally been employed for the determination of plasma concentration-time profiles for pharmacokinetic studies of therapeutic proteins and peptides. These ligand binding assays have high sensitivity but require significant time for antibody generation (1 to 2 years) for assay development. Despite high sensitivity, these assays suffer from cross-reactivity that can lead to inaccurate results. As an alternative to immunoassays, this dissertation was focused on the development and validation of assays that can be used for quantitative analysis of peptides or proteins in pl

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Adaway, Joanne E., Mirko Peitzsch, and Brian G. Keevil. "A novel method for the measurement of plasma metanephrines using online solid phase extraction-liquid chromatography tandem mass spectrometry." Sage, 2015. https://tud.qucosa.de/id/qucosa%3A35429.

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Background: Measurement of plasma metanephrine, normetanephrine and 3-methoxytyramine is useful in the diagnosis of phaeochromocytomas, but many assays require a large volume of plasma due to poor assay sensitivity, and often require lengthy sample preparation. Our aim was to develop a method for measurement of plasma metanephrines using a small sample volume with minimal hands-on preparation. Methods: Samples were deproteinised using 10 K spin filters prior to online solid phase extraction using a Waters Acquity UPLC Online SPE Manager (Waters, Manchester, UK) coupled to a Waters Xevo TQ-S ma

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Knee, Jose. "Determining the metabolic profiles in Drosophila melanogaster: Development and application of a novel ion-pairing liquid chromatography-mass spectrometry protocol." Thesis, Laurentian University of Sudbury, 2014. https://zone.biblio.laurentian.ca/dspace/handle/10219/2138.

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Genetic perturbations and foreign chemicals can result in a multitude of changes across a wide range of biochemical processes in a biological system. These perturbations may affect the metabolome, the small molecule metabolites in an organism. Recently, liquid-chromatography coupled to mass spectrometry (LC-MS) technology has been used to quantify large proportions of the metabolome, however standardized protocols are not yet available for use with Drosophila melanogaster. Here, I developed an ion-pairing LC-MS protocol for the metabolomic characterization of D. melanogaster and demonstrated i

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Trčková, Marie. "Využití metody LC/MS k analýze vybraných přírodních fyziologicky aktivních látek." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2008. http://www.nusl.cz/ntk/nusl-216232.

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Presented work is focused on application of combined instrumental method RP-HPLC/ESI-MS in analysis of several groups of natural compounds with positive physiological activities. Especially some antioxidants were studied in commonly and abundantly consumed food. Moreover some other substances than standard compounds were observed in complex dies. In conclusion the HPLC/ESI-MS method is comparatively advantageous in phenolic analysis, while another type of ionisation would be used in case of carotenoid compound.

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Ghezal, Salma. "Etude métabolomique par LC-MS/MS chez Plasmodium Falciparum, parasite responsable du Paludisme." Thesis, Montpellier 2, 2014. http://www.theses.fr/2014MON20179.

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La forme la plus sévère de paludisme est causée par le parasite unicellulaire P. falciparum. Lors de la phase intra-érythrocytaire de son développement, P. falciparum met en place des fonctions métaboliques nécessaires à son développement dans l'érythrocyte, à sa multiplication et enfin à sa dissémination vers d'autres érythrocytes. Comprendre et élucider les structures et les dynamiques du réseau métabolique chez le parasite, permettent de découvrir de nouvelles voies métaboliques et des étapes clefs qui peuvent jouer un rôle important dans le développement du parasite. Elles permettent égale

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Nukareddy, Praveena. "Quantification Of Mouse Cardiac Troponin I And Myosin Binding Protein C Phosphorylation By Liquid Chromatography-Mass Spectrometry (lc-Ms)." ScholarWorks @ UVM, 2018. https://scholarworks.uvm.edu/graddis/986.

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Heart failure is a major public health issue, with its prevalence estimated to be 6.5 million adults in the USA. Of the hospitalized heart failure (HF) cases, 50% are characterized by preserved ejection function (HFpEF). In HFpEF, the heart pumps a normal proportion of blood that enters it. However, thickening of the ventricular walls inhibits the chamber filling to normal volume. The direct basis of HFpEF is a slowed elongation of the cardiac muscle during the diastolic phase of the cardiac cycle. Elucidation of mechanisms that mediate relaxation of cardiac muscle could help understand the pa

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Smiljanic, Danijela. "Mass Spectrometry Interfaced with Ion Mobility or Liquid Chromatography Separation for the Analysis of Complex Mixtures." University of Akron / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=akron1323149449.

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Massey, Karen A., Anna M. Snelling, and Anna Nicolaou. "Quantitative analysis of surfactant deposits on human skin by liquid chromatography electrospray ionisation tandem mass spectrometry." Wiley, 2010. http://hdl.handle.net/10454/4574.

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no<br>Surfactants are commonly used as cleansing agents and yet there are concerns they may also have a role in skin irritation. Presently, the lack of suitable methods for quantitative and qualitative analysis of surfactant deposition on skin has hindered the in-depth investigation of such effects. Here, we report the application of reverse phase liquid chromatography electrospray ionisation mass spectrometry (LC/ESI-MS/MS) assays for two surfactants commonly used in consumer products, namely sodium lauryl ether sulphate (SLES) and laurylamidopropyl betaine (LAPB), to a baseline study aiming

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Tsai, Tsung-Heng. "Bayesian Alignment Model for Analysis of LC-MS-based Omic Data." Diss., Virginia Tech, 2014. http://hdl.handle.net/10919/64151.

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Liquid chromatography coupled with mass spectrometry (LC-MS) has been widely used in various omic studies for biomarker discovery. Appropriate LC-MS data preprocessing steps are needed to detect true differences between biological groups. Retention time alignment is one of the most important yet challenging preprocessing steps, in order to ensure that ion intensity measurements among multiple LC-MS runs are comparable. In this dissertation, we propose a Bayesian alignment model (BAM) for analysis of LC-MS data. BAM uses Markov chain Monte Carlo (MCMC) methods to draw inference on the model par

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Miranda, e. Silva Lígia Maria 1982. "Validação de método de análise de multiresíduos de defensivos agrícolas por GC-MS/MS e LC-MS/MS." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/254815.

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Orientador: Marcelo Alexandre Prado<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia de Alimentos<br>Made available in DSpace on 2018-08-21T09:52:53Z (GMT). No. of bitstreams: 1 MirandaeSilva_LigiaMaria_M.pdf: 148256 bytes, checksum: 789cac2002bb2e8dcb1bf70832d395b6 (MD5) Previous issue date: 2012<br>Resumo: O crescente aumento populacional em escala mundial, tornou necessário um grande esforço por parte da agricultura para aumentar, a cada ano, a produção de alimentos para atender as necessidades do mercado externo e interno do Brasil. Recursos técnicos

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Tang, Jianhua. "Development of a Novel Gradient Chromatofocusing Tandem Mass Spectrometry Technique for the Determination of Cationic Compounds in Biofluids; Identification of Caspase 3 Cleavage Sites of NHE-1 by High Performance Liquid Chromatography-Mass Spectrometry." Cleveland State University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=csu1247344073.

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Sundström, Ingela. "Liquid Chromatography-Mass Spectrometry as a Tool for Drug Metabolite Identification in Biological Fluids : With Application to Ketobemidone." Doctoral thesis, Uppsala University, Analytical Pharmaceutical Chemistry, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7909.

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<p>Electrospray ionization (ESI) mass spectrometry (MS) in combination with liquid chromatography (LC) is an excellent tool for the identification of drug metabolites. Utilizing this hyphenated technique in combination with proper sample pretreatment, the metabolic pathways of the analgesic drug ketobemidone were investigated in human urine and rat microdialysate from blood and brain. Two novel phase I metabolites (ketobemidone N-oxide and meta-hydroxymethoxyketobemidone) and three novel phase II metabolites (glucuronic acid conjugates of ketobemidone, norketobemidone and hydroxymethoxyketobem

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Jabot, Claire. "Développement de stratégies analytiques basées sur la LC-MS/MS pour la recherche de traces de pesticides et métabolites dans des matrices apicoles." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSE1216/document.

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Depuis plusieurs années, des mortalités anormalement élevées sont observées chez les abeilles, au niveau mondial. Plusieurs facteurs peuvent être à l’origine de ces phénomènes, dont l’utilisation de pesticides. Parmi ceux-ci, les insecticides de la famille des neonicotinoides et des pyrethrinoides ainsi que certains fongicides de la famille des carboxamides sont mis en cause. Les travaux présentés dans ce manuscrit sont consacrés au développement de méthodes analytiques pour l’identification, la détection et la quantification de 13 pesticides et leurs métabolites dans les abeilles et les produ

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Nascimento, DemÃtrius Fernandes do. "Quantification of drugs with antimicrobial activity by high performance liquid chromatography coupled to mass spectrometry (LC-MS/MS): application in studies of comparative pharmacokinetics." Universidade Federal do CearÃ, 2011. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=7045.

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Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico<br>Two robust, fast and sensitive methods for quantification of sulfamethoxazole (SMX), trimethoprim (TMP) and sulfadiazine (SDZ) in plasma using high performance liquid chromatography coupled to mass spectrometry (LC-MS/MS) was developed and validated. The methods involved liquid-liquid extraction with ethyl acetate using metoprolol and sulfamethoxazole as internal standards (PI). The chromatographic separations were performed using Genesis C18 column 100 x 2.1 mm, 4 microns (sulfadiazine) and Genesis C18 150 x 4.6 mm, 4 microns (S

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Methling, Maximilian [Verfasser]. "Detection of psychoactive substances (antidepressants, antipsychotics, benzodiazepines, alcohol) in human hair and other matrices using liquid chromatography-mass spectrometry (LC-MS/MS) / Maximilian Methling." Berlin : Freie Universität Berlin, 2020. http://d-nb.info/1217251324/34.

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Panditi, Venkata Reddy. "Assessment of the Occurrence and Potential Risks of Antibiotics and their Metabolites in South Florida Waters Using Liquid Chromatography Tandem Mass Spectrometry." FIU Digital Commons, 2013. http://digitalcommons.fiu.edu/etd/916.

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An automated on-line SPE-LC-MS/MS method was developed for the quantitation of multiple classes of antibiotics in environmental waters. High sensitivity in the low ng/L range was accomplished by using large volume injections with 10-mL of sample. Positive confirmation of analytes was achieved using two selected reaction monitoring (SRM) transitions per antibiotic and quantitation was performed using an internal standard approach. Samples were extracted using online solid phase extraction, then using column switching technique; extracted samples were immediately passed through liquid chromatogr

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Garst, Christopher, Makenie Fulmer, Doug Thewke, and Stacy D. Brown. "Optimized Extraction of 2-Arachidonyl Glycerol and Anandamide from Aortic Tissue and Plasma for Quantification by LC-MS/MS." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etsu-works/5304.

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Atherosclerosis is a disease characterized by plaque formation due to an accumulation of fat, cholesterol, and immune cells in the walls of arteries. If a plaque ruptures, an occlusive thrombosis may form that causes either a heart attack or stroke. Macrophages express CB-2 receptors, and are one type of immune cell that plays a role in plaque destabilization and rupture. Endocannabinoids anandamide (AEA) and 2-arachidonyl glycerol (2-AG) have been found to have activity on CB-1 and CB-2 receptors throughout the body and immune system. In this study, we investigated several sample preparation

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Rapholo, Akanyang Annah Faithful. "Comparing diene derivatisation methods of dry blood spot samples for vitamin D metabolites quantification by liquid chromatography-tandem mass spectrometry." Diss., University of Pretoria, 2017. http://hdl.handle.net/2263/63038.

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This dissertation describes the elucidation and implementation of derivatisation in the quantification of biologically active vitamin D metabolites in limited volume serum and dry blood spot samples (DBS) using the liquid chromatography tandem-mass spectrometry (LC-MS/MS) analytical technique. This manuscript describes in detail the development and validation of an analytical methodology, highlighting the role derivatisation and mass spectrometry plays in the structural characterisation and quantification of vitamin D metabolites. The first chapter reviews comprehensively, the history o

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Adusumilli, Harika. "Separation and identification of peptides by integrated multidimensional liquid chromatography-mass spectrometry (IMDLC-MS)." Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/6028.

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Thesis (M.S.)--University of Missouri-Columbia, 2007.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on April 15, 2008) Vita. Includes bibliographical references.

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Ansong, Godfred. "Analysis of plant polyphenols by high performance liquid chromatography/mass spectrometry and protein binding." Oxford, Ohio : Miami University, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=miami1083081905.

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Petsalo, A. (Aleksanteri). "Development of LC/MS techniques for plant and drug metabolism studies." Doctoral thesis, Oulun yliopisto, 2011. http://urn.fi/urn:isbn:9789514294419.

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Abstract Liquid chromatography (LC) combined with mass spectrometry (MS) is a powerful tool for qualitative and quantitative analytics of organic molecules from various matrices, and the use of this hyphenated technique is very common in bioanalytical laboratories. In this study, LC/MS methods and the required sample preparation applications were developed for plant flavonoid and drug metabolism studies. The main focus was in developing methods to be used during cytochrome P450 (CYP) -specific drug interaction studies. Traditional high performance liquid chromatography (HPLC) and new, more efﬁ

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Colnerud, Nilsson Emma. "Database for targeted drug screening with Liquid Chromatography - Time-Of-Flight Mass Spectrometry, (LC-TOFMS)." Thesis, Linköping University, Department of Physics, Chemistry and Biology, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-57965.

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<p>Today there are no fully general analytical techniques available for detection and confirmation of known and unknown substances in toxicological screening, further tools are therefore needed. The development of mass spectrometry with time-of-flight (TOF) detection is promising but there are still areas to be further developed and evaluated, both instrumentation and applications.</p><p>During 2009 The National Board of Forensic Medicine-Department of Forensic Genetics and Forensic Toxicology, (RMV) started cooperation with the instrumentation company Waters (Manchester, UK) and the Departmen

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Dennehy, Michelle K. "Studies on the role of nitrosamines in carcinogenssis : Part I, LC-ESI-MS trace detection of glyoxal-deoxyguanosine and O⁶-hydroxyethyldeoxyguanosine ; Part II, Nitrosation reactions of a methaqualone drug analog /." free to MU campus, to others for purchase, 2003. http://wwwlib.umi.com/cr/mo/fullcit?p3091917.

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Oshita, Daniele 1981. "Desenvolvimento e validação de método analítico para determinação de multirresíduos de agrotóxicos em morango por LC-MS/MS e comparação com UHPLC." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/250530.

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Orientador: Isabel Cristina Sales Fontes Jardim<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Química<br>Made available in DSpace on 2018-08-24T08:24:02Z (GMT). No. of bitstreams: 1 Oshita_Daniele_D.pdf: 4645263 bytes, checksum: 6628dba7b8449d1cf1f86afa3dcae9e2 (MD5) Previous issue date: 2013<br>Resumo: Este trabalho envolve o desenvolvimento, a otimização e a validação de um método analítico para determinação de multirresíduos de agrotóxicos em amostras de morango, por cromatografia líquida acoplada à espectrometria de massas sequencial (LC-MS/MS). No preparo de amos

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Washaya, Norbertta Nzwisisayi. "A prospective study to assess the value of liquid chromatography-tandem mass spectrometry in the management of paediatric poisoning at Red Cross War Memorial Children's Hospital, Cape Town, South Africa." Master's thesis, Faculty of Health Sciences, 2020. http://hdl.handle.net/11427/33972.

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Background: Paediatric poisoning is a common presentation to emergency departments worldwide. There is a paucity of data on the role of liquid chromatography-tandem mass spectrometry (LC-MS/MS), in the management of paediatric poisoning in low-and middle-income countries (LMICs). In high-income countries, most studies are retrospective, and few include children. Objective: The study describes the prevalence of liquid chromatography-tandem mass spectrometry confirmed paediatric poisoning at Red Cross War Memorial Children's Hospital, Cape Town, South Africa. Methods Children admitted with suspe

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Benson, Andrew James. "High-performance liquid chromatography (HPLC) and high-performance liquid chromatography mass spectrometry (HPLC/MS) for the analysis of date rape drugs." FIU Digital Commons, 2002. http://digitalcommons.fiu.edu/etd/1602.

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The drugs studied in this work have been reportedly used to commit drug-facilitated sexual assault (DFSA), commonly known as "date rape". Detection of the drugs was performed using high-performance liquid chromatography with ultraviolet detection (HPLC/UV) and identified with high performance-liquid chromatography mass spectrometry (HPLC/MS) using selected ion monitoring (SIM). The objective of this study was to develop a single HPLC method for the simultaneous detection, identification and quantitation of these drugs. The following drugs were simultaneously analyzed: Gamma-hydroxybutyrate (GH

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Alabbas, Alhumaidi. "Reversed-phase Ion-Pairing Ultra Performance Liquid Chromatography-Mass Spectrometry in Characterization of Glycosaminoglycans." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3547.

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Glycosaminoglycans (GAGs) are a family of linear bio-polysaccharides, which are heterogeneously modified with negatively charged sulfate and carboxylate groups. They are located on every cell surface, extracellular matrix or intracellular space in the body. GAGs are composed of alternating units of an amino sugars (glucosamine or galactosamine) and hexuronic acid/hexose (iduronic acid, glucoronic acid/ or galactose), which are linked by glycosidic bonds with different geometries. In recent years, GAGs have attracted considerable interest. GAGs play vital roles in fundamental biological process

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Egan, Martin Joseph. "Analysis of polyhydroxyalkaloids in plant extracts by chromatography and mass spectrometry : including sequential tandem MS." Thesis, University of Greenwich, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324932.

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Solak, Nilüfer. "Structural Characterization and Quantitative Analysis by Interfacing Liquid Chromatography and/or Ion Mobility Separation with Multi-Dimensional Mass Spectrometry." University of Akron / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=akron1270744150.

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Yu, Ke, and 余珂. "Exploring biodegradation of emerging pollutants using next generation sequencing and UPLC-MS-MS techniques." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/210615.

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This study was conducted to set up a systematic approach utilizing advantages of both wet lab and bioinformatic methodologies to study biodegradation abilities and microbial bacterial-functional relationship within bioremediation communities. Firstly, 11pharmaceuticals and personal care products (PPCPs)were selected as target chemicals for establishing an effective determination process in analyzing trace-level concentrations in the environment, and understanding the removal routes during pollutants removal process in wastewater treatment process using activated sludge. Ultra performance li

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Herrmann, Abigail Grace. "Proteomic response to metabolic stress and cellular dysfunction in relation to Alzheimer's disease." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/9546.

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Vascular risk factors inducing a state of chronic cerebral hypoperfusion and metabolic stress are thought to influence the onset and progression of Alzheimer’s disease (AD). To investigate the complex molecular changes underpinning cellular adaptation to metabolic stress, the first aim of this thesis was to define the proteomic response of the SH-SY5Y human neuroblastoma cell line after exposure to the metabolic challenge of oxygen glucose deprivation (OGD). 958 proteins across multiple subcellular compartments were detected and quantified by label-free liquid chromatography mass spectrometry

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Sillén, Sara. "Photodegradation study of 3,5-diamino-6-chloro- N-(2-(methylamino)ethyl)pyrazine-2-carboxamide using preparative SFC and LC-MS." Thesis, Uppsala universitet, Institutionen för farmaci, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-301500.

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In this project the photodegradation of 3,5-diamino-6-chloro-N-(2-(methylamino)ethyl)pyrazine-2-carboxamide was studied. A hypothetical degradation pattern for the compound was proposed and the aim of the project was to study the formed secondary photodegradants and to, if possible, structure elucidate some of these compounds. In order to do this, the parent compound was photodegraded in two steps, where a primary photodegradant was isolated using semi-preparative supercritical fluid chromatography (SFC) and then further degraded into the secondary photodegradants. The photodegradation was fir

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Alves, Claudete. "\"Análise de fármacos em fluidos biológicos empregando o acoplamento SPME-LC/MS\"." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/75/75132/tde-18042007-171857/.

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Os métodos convencionais para a determinação de fármacos em fluidos biológicos baseiam-se em técnicas cromatográficas e imunoquímicas. O tratamento prévio de amostras biológicas, o qual abrange as etapas de extração, pré-concentração e clean-up, tem sido requerido nas análises de fármacos, para aumentar a sensibilidade e seletividade analítica. No entanto, nos últimos anos, com o avanço das técnicas instrumentais, diversas técnicas têm sido avaliados para a análise de diferentes fármacos em fluidos biológicos, destacando-se entre elas a Microextração em Fase Sólida (SPME) e a Cromatografia L

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Abaniwonda, Ibukunoluwa Mercy. "Determination of kanamycin plasma concentrations using LC/MS and pharmacokinetics of kanamycin in patients with multidrug-resistant tuberculosis and in patients with multidrug-resistant tuberculosis co-infected with HIV." Thesis, University of the Western Cape, 2012. http://hdl.handle.net/11394/3792.

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Magister Pharmaceuticae - MPharm<br>The aim of the study was to determine firstly, kanamycin plasma concentrations using liquid chromatography coupled with mass spectrometry (LC/MS); secondly, to investigate the PK parameters of kanamycin in patients infected with MDR-TB and in patients co-infected with MDR-TB and HIV; thirdly, to assess the influence of HIV infection and renal impairment on the PK of kanamycin and fourthly, to find out whether there is any interaction between antiretroviral drugs and kanamycin.

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