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Articles de revues sur le sujet « MBNH3 »

Auteur : Grafiati

Publié le 25 juillet 2024

Mis à jour le 31 juillet 2025

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1

Sun, Xueqin, Xinghua Diao, Xiaolin Zhu, Xuexue Yin, and Guangying Cheng. "Nanog-mediated stem cell properties are critical for MBNL3-associated paclitaxel resistance of ovarian cancer." Journal of Biochemistry 169, no. 6 (2021): 747–56. http://dx.doi.org/10.1093/jb/mvab021.

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Abstract Paclitaxel (PTX) is the standard first-line treatment of ovarian cancer, but its efficacy is limited by multidrug resistance. Therefore, it is crucial to identify effective drug targets to facilitate PTX sensitivity for ovarian cancer treatment. Seventy PTX-administrated ovarian cancer patients were recruited in this study for gene expression and survival rate analyses. Muscleblind-like-3 (MBNL3) gain-of-function and loss-of-function experiments were carried out in ovarian cancer cells (parental and PTX-resistant) and xenograft model. Cancer cell viability, apoptosis, spheroids format

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Holm, Frida, Eva Hellqvist, Cayla N. Mason, et al. "Reversion to an embryonic alternative splicing program enhances leukemia stem cell self-renewal." Proceedings of the National Academy of Sciences 112, no. 50 (2015): 15444–49. http://dx.doi.org/10.1073/pnas.1506943112.

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Formative research suggests that a human embryonic stem cell-specific alternative splicing gene regulatory network, which is repressed by Muscleblind-like (MBNL) RNA binding proteins, is involved in cell reprogramming. In this study, RNA sequencing, splice isoform-specific quantitative RT-PCR, lentiviral transduction, and in vivo humanized mouse model studies demonstrated that malignant reprogramming of progenitors into self-renewing blast crisis chronic myeloid leukemia stem cells (BC LSCs) was partially driven by decreased MBNL3. Lentiviral knockdown of MBNL3 resulted in reversion to an embr

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Guendouz, Dj, Z. Charifi, H. Baaziz, et al. "Electronic structure, optical and thermodynamic properties of ternary hydrides MBeH3 (M = Li, Na, and K)." Canadian Journal of Physics 94, no. 9 (2016): 865–76. http://dx.doi.org/10.1139/cjp-2016-0299.

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Electronic band structure, optical and thermodynamic properties of ternary hydrides MBeH3 (M = Li, Na, and K) were studied using ab initio density functional theory (DFT). The effect of the adopted approximation to the exchange-correlation functional of the DFT is explicitly investigated by considering four different expressions of two different classes (local-density approximation and generalized-gradient approximation). The calculated magnitude of B classifies MBeH3 (M = Li, Na, and K) as easily compressible materials. The bonding interaction in these compounds is quite complicated. The inte

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Manesis, Anastasia C., Richard J. Jodts, Brian M. Hoffman, and Amy C. Rosenzweig. "Copper binding by a unique family of metalloproteins is dependent on kynurenine formation." Proceedings of the National Academy of Sciences 118, no. 23 (2021): e2100680118. http://dx.doi.org/10.1073/pnas.2100680118.

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Some methane-oxidizing bacteria use the ribosomally synthesized, posttranslationally modified natural product methanobactin (Mbn) to acquire copper for their primary metabolic enzyme, particulate methane monooxygenase. The operons encoding the machinery to biosynthesize and transport Mbns typically include genes for two proteins, MbnH and MbnP, which are also found as a pair in other genomic contexts related to copper homeostasis. While the MbnH protein, a member of the bacterial diheme cytochrome c peroxidase (bCcP)/MauG superfamily, has been characterized, the structure and function of MbnP,

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Wang, Xianxian, Yanchao Cai, Xiucheng Liu, and Cunfu He. "Quantitative Prediction of Surface Hardness in Cr12MoV Steel and S136 Steel with Two Magnetic Barkhausen Noise Feature Extraction Methods." Sensors 24, no. 7 (2024): 2051. http://dx.doi.org/10.3390/s24072051.

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The correlation between magnetic Barkhausen noise (MBN) features and the surface hardness of two types of die steels (Cr12MoV steel and S136 steel in Chinese standards) was investigated in this study. Back-propagation neural network (BP-NN) models were established with MBN magnetic features extracted by different methods as the input nodes to realize the quantitative prediction of surface hardness. The accuracy of the BP-NN model largely depended on the quality of the input features. In the extraction process of magnetic features, simplifying parameter settings and reducing manual intervention

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Kanadia, Rahul N., Carl R. Urbinati, Valerie J. Crusselle, et al. "Developmental expression of mouse muscleblind genes Mbnl1, Mbnl2 and Mbnl3." Gene Expression Patterns 3, no. 4 (2003): 459–62. http://dx.doi.org/10.1016/s1567-133x(03)00064-4.

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Holm, Frida Linnea, Eva Hellqvist, Cayla N. Mason, et al. "Reversion to an Embryonic Alternative Splicing Program Enhances Leukemia Stem Cell Self-Renewal." Blood 126, no. 23 (2015): 1227. http://dx.doi.org/10.1182/blood.v126.23.1227.1227.

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Abstract Background Formative research suggests that a human embryonic stem cell-specific alternative splicing gene regulatory network, which is repressed by Muscleblind-like (MBNL) RNA binding proteins, is involved in cell reprogramming. However, its role in malignant reprogramming of progenitors into self-renewing leukemia stem cells (LSCs) had not been established. Methods Whole transcriptome RNA sequencing (RNA-seq) was performed on FACS purified progenitors from normal, chronic phase and blast crisis chronic myeloid leukemia samples and analyzed using Cuff-links, GSEA and IPA software. Sp

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Lee, Kyung-Soon, Kimberly Smith, Paul S. Amieux, and Edith H. Wang. "MBNL3/CHCR prevents myogenic differentiation by inhibiting MyoD-dependent gene transcription." Differentiation 76, no. 3 (2008): 299–309. http://dx.doi.org/10.1111/j.1432-0436.2007.00209.x.

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Grammatikakis, Ioannis, Young-Hwa Goo, Gloria V. Echeverria, and Thomas A. Cooper. "Identification of MBNL1 and MBNL3 domains required for splicing activation and repression." Nucleic Acids Research 39, no. 7 (2010): 2769–80. http://dx.doi.org/10.1093/nar/gkq1155.

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Helbing, Jan. "Spin state transitions upon visible and infrared excitation of ferric MbN3." Chemical Physics 396 (March 2012): 17–22. http://dx.doi.org/10.1016/j.chemphys.2011.04.001.

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Kenney, Grace E., Laura M. K. Dassama, Anastasia C. Manesis, et al. "MbnH is a diheme MauG-like protein associated with microbial copper homeostasis." Journal of Biological Chemistry 294, no. 44 (2019): 16141–51. http://dx.doi.org/10.1074/jbc.ra119.010202.

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Lin, Jian, Ya T. Chen, Jing Xia, and Qian Yang. "MiR674 inhibits the neuraminidase-stimulated immune response on dendritic cells via down-regulated Mbnl3." Oncotarget 7, no. 31 (2016): 48978–94. http://dx.doi.org/10.18632/oncotarget.9832.

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Wulsin, Lawson R., Lesley M. Arnold, and J. Randolph Hillard. "Axis I Disorders in Er Patients with Atypical Chest Pain." International Journal of Psychiatry in Medicine 21, no. 1 (1991): 37–46. http://dx.doi.org/10.2190/hfq4-j41n-6m1e-mbn3.

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Vajeeston, P., P. Ravindran, and H. Fjellvåg. "Structural Phase Stability Studies on MBeH3(M = Li, Na, K, Rb, Cs) from Density Functional Calculations." Inorganic Chemistry 47, no. 2 (2008): 508–14. http://dx.doi.org/10.1021/ic7015897.

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Lee, Kyung-Soon, Yi Cao, Hanna E. Witwicka, Susan Tom, Stephen J. Tapscott та Edith H. Wang. "RNA-binding Protein Muscleblind-like 3 (MBNL3) Disrupts Myocyte Enhancer Factor 2 (Mef2) β-Exon Splicing". Journal of Biological Chemistry 285, № 44 (2010): 33779–87. http://dx.doi.org/10.1074/jbc.m110.124255.

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Bhutani, Namita, Rajat Maheshwari, Monika Negi, and Pooja Suneja. "Optimization of IAA production by endophytic Bacillus spp. from Vigna radiata for their potential use as plant growth promoters." Israel Journal of Plant Sciences 65, no. 1-2 (2018): 83–96. http://dx.doi.org/10.1163/22238980-00001025.

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Endophytic bacteria isolated from nodules of Vigna radiata were screened for indole acetic acid (IAA) production. Three isolates MBN3, MJHN1 and MJHN10, molecularly identified as Bacillus aryabhattai (MF693121.1), B. megaterium (MF693120.1) and B. cereus (MF693119.1) were producing significantly high amount of IAA. Production parameters viz. L-tryptophan concentration, incubation time, carbon and nitrogen sources were optimized. The study revealed the presence of trp-dependent pathway for IAA production in the isolates. All of them gave maximum production with yeast extract as nitrogen source

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Yu, Zhanwu, Gebang Wang, Chenlei Zhang, et al. "LncRNA SBF2-AS1 affects the radiosensitivity of non-small cell lung cancer via modulating microRNA-302a/MBNL3 axis." Cell Cycle 19, no. 3 (2020): 300–316. http://dx.doi.org/10.1080/15384101.2019.1708016.

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Yuan, Ji-hang, Xiao-ning Liu, Tian-tian Wang, et al. "The MBNL3 splicing factor promotes hepatocellular carcinoma by increasing PXN expression through the alternative splicing of lncRNA-PXN-AS1." Nature Cell Biology 19, no. 7 (2017): 820–32. http://dx.doi.org/10.1038/ncb3538.

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Balsara, Rashna D., and Vasudha P. Joshi. "Molecular Basis of UV-Sensitive Mutant Strain MBH3 of Haemophilus Influenzae Rd: Identification of Mutation in the uvrA Gene." Journal of Environmental Pathology, Toxicology and Oncology 20, no. 1 (2001): 6. http://dx.doi.org/10.1615/jenvironpatholtoxicoloncol.v20.i1.50.

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Maasalu, Katre, Ott Laius, Lidiia Zhytnik, et al. "Featured Article: Transcriptional landscape analysis identifies differently expressed genes involved in follicle-stimulating hormone induced postmenopausal osteoporosis." Experimental Biology and Medicine 242, no. 2 (2016): 203–13. http://dx.doi.org/10.1177/1535370216679899.

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Osteoporosis is a disorder associated with bone tissue reorganization, bone mass, and mineral density. Osteoporosis can severely affect postmenopausal women, causing bone fragility and osteoporotic fractures. The aim of the current study was to compare blood mRNA profiles of postmenopausal women with and without osteoporosis, with the aim of finding different gene expressions and thus targets for future osteoporosis biomarker studies. Our study consisted of transcriptome analysis of whole blood serum from 12 elderly female osteoporotic patients and 12 non-osteoporotic elderly female controls.

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Negrón-Pérez, Verónica M., Yanping Zhang, and Peter J. Hansen. "Single-cell gene expression of the bovine blastocyst." Reproduction 154, no. 5 (2017): 627–44. http://dx.doi.org/10.1530/rep-17-0345.

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The first two differentiation events in the embryo result in three cell types – epiblast, trophectoderm (TE) and hypoblast. The purpose here was to identify molecular markers for each cell type in the bovine and evaluate the differences in gene expression among individual cells of each lineage. The cDNA from 67 individual cells of dissociated blastocysts was used to determine transcript abundance for 93 genes implicated as cell lineage markers in other species or potentially involved in developmental processes. Clustering analysis indicated that the cells belonged to two major populations (cla

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López, Castel Arturo. "Development of a Drosophila melanogaster spliceosensor system for in vivo high-throughput screening in myotonic dystrophy type 1." Dis Model Mech 7, no. 11 (2014): 1297–306. https://doi.org/10.1242/dmm.016592.

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Alternative splicing of pre-mRNAs is an important mechanism that regulates cellular function in higher eukaryotes. A growing number of human genetic diseases involve splicing defects that are directly connected to their pathology. In myotonic dystrophy type 1 (DM1), several clinical manifestations have been proposed to be the consequence of tissue-specific missplicing of numerous genes. These events are triggered by an RNA gain-of-function and resultant deregulation of specific RNA-binding factors, such as the nuclear sequestration of muscleblind-like family factors (MBNL1-MBNL3). Thus, the id

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Geng, Qiaohong, and Peifu Jiao. "Anti-PD-L1-Based Bispecific Antibodies Targeting Co-Inhibitory and Co-Stimulatory Molecules for Cancer Immunotherapy." Molecules 29, no. 2 (2024): 454. http://dx.doi.org/10.3390/molecules29020454.

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Targeting PD-L1 via monospecific antibodies has shown durable clinical benefits and long-term remissions where patients exhibit no clinical cancer signs for many years after treatment. However, the durable clinical benefits and long-term remissions by anti-PD-L1 monotherapy have been limited to a small fraction of patients with certain cancer types. Targeting PD-L1 via bispecific antibodies (referred to as anti-PD-L1-based bsAbs) which can simultaneously bind to both co-inhibitory and co-stimulatory molecules may increase the durable antitumor responses in patients who would not benefit from P

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Neslihan, HEKİM. "SOX9 delesyonunun IN SILICO analizi." Gevher Nesibe Journal of Medical & Health Sciences 8, Özel Sayı (2023): 826–32. https://doi.org/10.5281/zenodo.8404309.

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SOX9 geni, embriyonal gelişimde cinsiyetin belirlenmesinde, kondrosit farklılaşması ve iskelet gelişiminde kilit rol oynayan bir transkripsiyon faktörüdür. SOX9 ekspresyonundaki azalma sıklıkla cinsiyet gelişim bozukluklarıyla birlikte gözlenen bir iskelet malformasyon sendromu olan kampomelik displaziye yol açar. MiRNA’lar tam ya da kısmi komplementerlikleri sayesinde hedef transkriptlerinin ekspresyonlarını düzenleyen önemli aracılardır. SOX9 geninin delesyonu, bu geni hedefleyen miRNA’ların ekspresyon seviyelerinde artışa ve dolayısıyla diğer

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Gao, Xiaoling, Wenhao Zhang, Yanjuan Jia, Hui Xu, Yuchen Zhu, and Xiong Pei. "Identification of a prognosis-related ceRNA network in cholangiocarcinoma and potentially therapeutic molecules using a bioinformatic approach and molecular docking." Scientific Reports 12, no. 1 (2022). http://dx.doi.org/10.1038/s41598-022-20362-w.

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AbstractCholangiocarcinoma (CCA) is a highly malignant disease with a poor prognosis, and mechanisms of initiation and development are not well characterized. It is long noncoding RNAs (lncRNAs) acting as miRNA decoys to regulate cancer-related RNAs in competing endogenous RNA (ceRNA) networks that suggest a possible molecular mechanism in CCA. The current study aims to find potential prognosis biomarkers and small molecule therapeutic targets based on the construction of a CCA prognosis-related ceRNA network. A transcriptome dataset for CCA was downloaded from the TCGA database. Differentiall

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Park, Seongchul, Jooyoung Kim, and Manho Lim. "Photoexcitation dynamics of azide ion bound ferric myoglobin probed by femtosecond infrared spectroscopy." Bulletin of the Korean Chemical Society, November 29, 2023. http://dx.doi.org/10.1002/bkcs.12803.

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AbstractThe photoexcitation dynamics of N3−‐bound ferric myoglobin (MbN3) were investigated after exciting MbN3 in D2O at 283 K with a 575 nm pulse by probing the anti‐symmetric stretching mode of the azide. Global fitting of the overall time‐resolved spectra revealed that thermal relaxation of two stretching bands proceeded with a time constant of 6 ps, and that a new absorption band formed and decayed with time constants of 0.6 and 23 ps, respectively. The new absorption near 2040 cm−1 was attributed to the high‐spin species 2.4 kJ/mol above the low‐spin species, as the excited low‐spin rela

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Oladimeji, Peter O., Jesse Bakke, William C. Wright, and Taosheng Chen. "KANSL2 and MBNL3 are regulators of pancreatic ductal adenocarcinoma invasion." Scientific Reports 10, no. 1 (2020). http://dx.doi.org/10.1038/s41598-020-58448-y.

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Dastidar, Sumitava, Debanjana Majumdar, Jaitip Tipanee, et al. "Comprehensive transcriptome-wide analysis of spliceopathy correction of myotonic dystrophy using CRISPR-Cas9 in iPSCs-derived cardiomyocytes." Molecular Therapy 30, no. 1 (2022). https://doi.org/10.1016/j.ymthe.2021.08.004.

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<strong>Abstract</strong> <em>CTG</em> repeat expansion (<em>CTG</em><em>exp</em>) is associated with aberrant alternate splicing that contributes to cardiac dysfunction in myotonic dystrophy type 1 (DM1). Excision of this <em>CTG</em>exp repeat using CRISPR-Cas resulted in the disappearance of punctate ribonuclear foci in cardiomyocyte-like cells derived from DM1-induced pluripotent stem cells (iPSCs). This was associated with correction of the underlying spliceopathy as determined by RNA sequencing and alternate splicing analysis. Certain genes were of particular int

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Manesis, Anastasia C., Jeffrey W. Slater, Kenny Cantave, J. Martin Bollinger, Carsten Krebs, and Amy C. Rosenzweig. "Capturing a bis-Fe(IV) State in Methylosinus trichosporium OB3b MbnH." Biochemistry, February 22, 2023. http://dx.doi.org/10.1021/acs.biochem.3c00021.

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Vajeeston, P., P. Ravindran, and H. Fjellvaag. "ChemInform Abstract: Structural Phase Stability Studies on MBeH3(M: Li, Na, K, Rb, Cs) from Density Functional Calculations." ChemInform 39, no. 12 (2008). http://dx.doi.org/10.1002/chin.200812003.

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Hinman, Melissa N., Jared I. Richardson, Rose A. Sockol, et al. "Zebrafish mbnl mutants model physical and molecular phenotypes of myotonic dystrophy." Disease Models & Mechanisms 14, no. 6 (2021). http://dx.doi.org/10.1242/dmm.045773.

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ABSTRACT The muscleblind RNA-binding proteins (MBNL1, MBNL2 and MBNL3) are highly conserved across vertebrates and are important regulators of RNA alternative splicing. Loss of MBNL protein function through sequestration by CUG or CCUG RNA repeats is largely responsible for the phenotypes of the human genetic disorder myotonic dystrophy (DM). We generated the first stable zebrafish (Danio rerio) models of DM-associated MBNL loss of function through mutation of the three zebrafish mbnl genes. In contrast to mouse models, zebrafish double and triple homozygous mbnl mutants were viable to adultho

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Zhou, Jixiang, Tuoen Liu, Hongjuan Xu, Yong Wang, and Ling Liu. "LncRNA FIRRE promotes the proliferation and metastasis of hepatocellular carcinoma by regulating the expression of PXN through interacting with MBNL3." Biochemical and Biophysical Research Communications, July 2022. http://dx.doi.org/10.1016/j.bbrc.2022.07.099.

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Tang, Weiping, Can Huang, Bing Jiang, Junjun Lin, and Yecai Lu. "MBNL3 Acts as a Target of miR-302e to Facilitate Cell Proliferation, Invasion and Angiogenesis of Gastric Adenocarcinoma via AKT/VEGFA Pathway." Journal of Microbiology and Biotechnology, May 30, 2024. http://dx.doi.org/10.4014/jmb.2401.01027.

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Wu, Yan, Jianhong Wang, Bo Chen, Yuxue Guo, Ping Gan, and Yanbing Han. "Identification of the microglia-associated signature in experimental autoimmune encephalomyelitis." Frontiers in Immunology 16 (June 5, 2025). https://doi.org/10.3389/fimmu.2025.1581878.

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BackgroundMultiple sclerosis (MS) is a chronic neuroinflammatory disorder characterized by demyelination and immune dysregulation, and microglia play a central role in disease progression. Despite this, the specific microglial gene signatures contributing to MS remain inadequately characterized.MethodsWe utilized an experimental autoimmune encephalomyelitis (EAE) mouse model and performed RNA sequencing to identify differentially expressed Messenger RNAs (DEmRNAs), Long Non-Coding RNAs (DElncRNAs), Circular RNAs (DEcircRNAs), and microRNAs (DEmiRNAs) in microglia. A machine learning approach i

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Smitchger, Jamin A., J. Bret Taylor, Michelle R. Mousel, et al. "Genome-wide associations with longevity and reproductive traits in U.S. rangeland ewes." Frontiers in Genetics 15 (May 27, 2024). http://dx.doi.org/10.3389/fgene.2024.1398123.

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Introduction: Improving ewe longevity is an important breeding and management goal, as death loss and early culling of mature ewes are economic burdens in the sheep industry. Ewe longevity can be improved by selecting for positive reproductive outcomes. However, the breeding approaches for accomplishing this come with the challenge of recording a lifetime trait. Characterizing genetic factors underpinning ewe longevity and related traits could result in the development of genomic selection strategies to improve the stayability of sheep through early, informed selection of replacement ewes.Meth

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Sanchez, Marie-Pierre, Clémentine Escouflaire, Aurélia Baur, et al. "X-linked genes influence various complex traits in dairy cattle." BMC Genomics 24, no. 1 (2023). http://dx.doi.org/10.1186/s12864-023-09438-7.

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Abstract Background The search for quantitative trait loci (QTL) affecting traits of interest in mammals is frequently limited to autosomes, with the X chromosome excluded because of its hemizygosity in males. This study aimed to assess the importance of the X chromosome in the genetic determinism of 11 complex traits related to milk production, milk composition, mastitis resistance, fertility, and stature in 236,496 cows from three major French dairy breeds (Holstein, Montbéliarde, and Normande) and three breeds of regional importance (Abondance, Tarentaise, and Vosgienne). Results Estimates

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