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Bibliographies thématiques / Membranotropic compounds

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Littérature scientifique sur le sujet « Membranotropic compounds »

Auteur : Grafiati

Publié le 5 octobre 2023

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Articles de revues sur le sujet "Membranotropic compounds"

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Sokolova, S. M., G. N. Buzuk, M. Ya Lovkova, and Yu V. Tyutekin. "Membranotropic Compounds and Alkaloid Accumulation in Plants." Doklady Biochemistry and Biophysics 402, no. 1-6 (2005): 220–22. http://dx.doi.org/10.1007/s10628-005-0075-x.

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Dubinin, Mikhail V., Vyacheslav A. Sharapov, Alena A. Semenova, et al. "Effect of Modified Levopimaric Acid Diene Adducts on Mitochondrial and Liposome Membranes." Membranes 12, no. 9 (2022): 866. http://dx.doi.org/10.3390/membranes12090866.

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This paper demonstrates the membranotropic effect of modified levopimaric acid diene adducts on liver mitochondria and lecithin liposomes. We found that the derivatives dose-dependently reduced the efficiency of oxidative phosphorylation of mitochondria due to inhibition of the activity of complexes III and IV of the respiratory chain and protonophore action. This was accompanied by a decrease in the membrane potential in the case of organelle energization both by glutamate/malate (complex I substrates) and succinate (complex II substrate). Compounds 1 and 2 reduced the generation of H2O2 by m

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Shabanov, Petr Dmitrievich, Anatoliy Ivanovich Vislobokov, Georgiy Nolianovich Shilov, P. M. Bulay, and A. P. Lugovskii. "Changes in intracellular potentials and ionic currents of the mollusk and activity of Cl--channels under exposure to some inhibitory amino acids and new litium-containing compounds of them." Reviews on Clinical Pharmacology and Drug Therapy 13, no. 3 (2015): 39–47. http://dx.doi.org/10.17816/rcf13339-47.

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The Changes of membrane rest potential (RP), action potential (AP), impulse activity (IA) as well as sodium, calcium and potassium ionic currents in neurons of isolated central nervous system of the Planorbarius corneus mollusk (pedal ganglia) under the extracellular action of inhibitory amino acids GABA, glycine and β-alanine and their litium-containing derivatives (LCD) in 0.1, 1 and 5 mM concentrations have been studied using a microelectrode technique. They induced the same dose-dependent and irreversible depolarization of neurons on 2-10 mV accompanied by increase of AP frequency, prolong

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Akhmedov, Alan A., Dmitriy N. Shurpik, Zainab R. Latypova, Rustem R. Gamirov, and Ivan I. Stoykov. "Synthetic meroterpenoids based on terpene alcohols: synthesis, self-assembly, and membranotropic properties." Butlerov Communications 63, no. 7 (2020): 11–18. http://dx.doi.org/10.37952/roi-jbc-01/20-63-7-11.

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Currently, targeted drug delivery is of great interest in the field of medicine. The study of compounds capable of permeating cell membranes is a major problem in this area. The synthesis of pharmacologically active compounds includes the formation of structures with various combinations of pharmacophore fragments and properties. Amphiphilic compounds tend to exhibit membranotropic activity. From this point of view, the modification of natural products, especially terpenoids, is of particular interest. Terpenoid structures are used as membrane anchors in the development of modulators for membr

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Logashenko, E. B., I. L. Kuznetsova, E. I. Ryabchikova, V. V. Vlassov, and M. A. Zenkova. "Mechanism of the toxicity of the artificial ribonucleases for the different human cancer cell lines." Biomeditsinskaya Khimiya 56, no. 2 (2010): 230–43. http://dx.doi.org/10.18097/pbmc20105602230.

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The ability of artificial ribonucleases to cause in the concentration-dependent manner death of cancer cells has been studied. The cytotoxic activity of artificial ribonucleases is observed at rather low concentration of these compounds (10-5 М). Analysis of the mechanism of artificial ribonucleases citotoxicity revealed that compounds under the study exhibit membranotropic activity in addition to ribonucleases activity found earlier. This activity is responsible for effective penetration of these compounds inside cells. The results obtained show that artificial ribonucleases induce cell death

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Garaev, T. M., T. V. Grebennikova, V. V. Avdeeva, V. V. Lebedeva, and V. F. Larichev. "Antiviral properties of synthetic histidine derivatives containing membranotropic volumetrical carbocycles in their molecule against SARS-CoV-2 virus <i>in vitro</i>." Problems of Virology 68, no. 1 (2023): 18–25. http://dx.doi.org/10.36233/0507-4088-147.

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Introduction. Currently, low molecular-weight compounds are being developed as potential inhibitors of CoVs replication, targeting various stages of the replication cycle, such as major protease inhibitors and nucleoside analogs. Viroporins can be alternative protein targets. The aim of this study is to identify antiviral properties of histidine derivatives with cage substituents in relation to pandemic strain SARS-CoV-2 in vitro. Materials and methods. Combination of histidine with aminoadamantane and boron cluster anion [B10H10]2 (compounds IIV) was carried out by classical pepti

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Avdeeva, V. V., T. M. Garaev, E. A. Malinina, K. Yu Zhizhin, and N. T. Kuznetsov. "Physiologically Active Compounds Based on Membranotropic Cage Carriers–Derivatives of Adamantane and Polyhedral Boron Clusters (Review)." Russian Journal of Inorganic Chemistry 67, no. 1 (2022): 28–47. http://dx.doi.org/10.1134/s0036023622010028.

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Amerkhanova, Syumbelya K., Alexandra D. Voloshina, Alla B. Mirgorodskaya, et al. "Antimicrobial Properties and Cytotoxic Effect of Imidazolium Geminis with Tunable Hydrophobicity." International Journal of Molecular Sciences 22, no. 23 (2021): 13148. http://dx.doi.org/10.3390/ijms222313148.

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Antimicrobial, membranotropic and cytotoxic properties of dicationic imidazolium surfactants of n-s-n (Im) series with variable length of alkyl group (n = 8, 10, 12, 14, 16) and spacer fragment (s = 2, 3, 4) were explored and compared with monocationic analogues. Their activity against a representative range of Gram-positive and Gram-negative bacteria, and also fungi, is characterized. The relationship between the biological activity and the structural features of these compounds is revealed, with the hydrophobicity emphasized as a key factor. Among dicationic surfactants, decyl derivatives sh

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KUKOVINETS, О. S., R. KH MUDARISOVA, A. A. VAKULSKAYA, and A. R. ISAEVA. "TECHNOLOGY FOR OBTAINING NEW BIOLOGICALLY ACTIVE PECTIN MATERIALS MODIFIED WITH L-TRIPTOFAN." Fundamental and Applied Problems of Engineering and Technology, no. 4 (2021): 28–32. http://dx.doi.org/10.33979/2073-7408-2021-348-4-28-32.

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New polymer complexes of copper (II) were obtained on the basis of apple pectin modified with the amino acid L-tryptophan. The stoichiometry of the complexes formed was determined by spectrophotometric methods, and the stability constants and standard thermodynamic characteristics of the complexation process (Hº; Gº; Sº) were calculated. It was found that the interaction of pectin modified with an amino acid with Cu (II) cations leads to the formation of enthalpy - entropy stabilized metal complex compounds. The IR spectral method showed that the coordination interaction of copper (II) cati

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Roman’ko, M. Y. "Biochemical markers of safety of nano-particles of metals on the model of isolated subcultural fractions of eukaryotes." Regulatory Mechanisms in Biosystems 8, no. 4 (2017): 564–68. http://dx.doi.org/10.15421/021787.

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Unique sizes and a high level of bioavailability allow nanoparticles of metals (NPMe) to come into direct contact with biological systems, with infectious agents, toxins, as well as with different chemical compounds and separate cell structures (proteins, lipids, nucleic acids). Other biological effects, including less toxicity than in microscopic substances, require attention to be paid to the study of the potential risk of using nanoparticles of each type in a particular way, therefore scientific support is absolutely necessary in this direction. It is believed that the cytotoxicity of nanom

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Thèses sur le sujet "Membranotropic compounds"

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Botcazon, Camille. "Etude du mode d'action de composés antifongiques membranotropes naturels sur deux Sclerotiniacées : cas des rhamnolipides et des fengycines." Electronic Thesis or Diss., Compiègne, 2023. https://bibliotheque.utc.fr/Default/doc/SYRACUSE/2023COMP2755.

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Les rhamnolipides (RLs) et les fengycines (FGs), des composés sécrétés par des bactéries, ont des propriétés antifongiques contre les champignons phytopathogènes Sclerotinia sclerotiorum et Botrytis cinerea. Cependant, les effets biocides induits et les mécanismes impliqués sont peu étudiés chez les champignons. De par leur caractère amphiphile, un mode d’action membranotrope est proposé pour ces composés intéréssants pour le biocontrôle. Les travaux présentés ici démontrent que les deux Sclérotiniacées ont des sensibilités opposées aux RLs et aux FGs. Une étude en microscopie montre que les R

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