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Articles de revues sur le sujet « Mesothelial hyperplasia »

Auteur : Grafiati

Publié le 7 juin 2025

Mis à jour le 2 août 2025

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1

Clement, Philip B., and Robert H. Young. "Histiocytic/Mesothelial Hyperplasia." American Journal of Surgical Pathology 22, no. 8 (1998): 1036–37. http://dx.doi.org/10.1097/00000478-199808000-00018.

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Chan, John K. C. "Histiocytic/Mesothelial Hyperplasia." American Journal of Surgical Pathology 22, no. 8 (1998): 1037. http://dx.doi.org/10.1097/00000478-199808000-00019.

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Park, Kyeoungseo, Kyeongmin Kim, Yon Hee Kim, et al. "Papillary Histiocytic and Mesothelial Hyperplasia of the Ovary Related to a Huge Uterus: A Case Report." Soonchunhyang Medical Science 29, no. 1 (2023): 10–14. http://dx.doi.org/10.15746/sms.23.003.

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Nodular histiocytic/mesothelial hyperplasia (NHMH) is a very rare condition. It is generally thought to be associated with repeated mechanical or chemical stimulation. This study reported NHMH with papillary growth pattern in the ovary following high-intensity focused ultrasound (HIFU) treatment for uterine leiomyoma and adenomyosis. A 48-year-old female, who had a history of undergoing HIFU treatment 7 times for adenomyosis and leiomyoma of the uterus 6 months ago, was referred to the hospital. After the hysterectomy and right salpingo-oophorectomy, the patient was confirmedly diagnosed with

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Cagle, Philip T., and Andrew Churg. "Differential Diagnosis of Benign and Malignant Mesothelial Proliferations on Pleural Biopsies." Archives of Pathology & Laboratory Medicine 129, no. 11 (2005): 1421–27. http://dx.doi.org/10.5858/2005-129-1421-ddobam.

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Abstract Context.—Although much of the pathology literature focuses on differential diagnosis of diffuse malignant mesothelioma from other types of cancer, the primary diagnostic challenge facing the pathologist is often whether a mesothelial proliferation on a pleural biopsy represents a malignancy or a benign reactive hyperplasia. Design.—Based on previous medical publications, extensive personal consultations, and experience on the United States–Canadian Mesothelioma Reference Panel and the International Mesothelioma Panel, salient information was determined about interpretation of benign v

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5

Shidham, Vinod B. "The panorama of different faces of mesothelial cells." Cytojournal 18 (December 6, 2021): 31. http://dx.doi.org/10.25259/cmas_02_02_2021.

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All effusions in serous cavities represent a pathologic processes secondary to inflammatory, neoplastic, hemodynamic, or mechanical/traumatic etiologies. This elicits reactive changes in the extremely sensitive mesothelial cells lining the serosal surfaces. The result is hypertrophy and hyperplasia which lead to broad changes with a wide range of morphological appearances. These reversible alterations may resolve entirely after the recovery of underlying pathology. Under the tertiary care situations, neoplastic effusion specimens are encountered more frequently. Although some non-neoplastic pa

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Kanso, Mohamad, Cleo Massad, Nina Shabb, et al. "Exuberant mesothelial proliferation mimicking malignant mesothelioma in a patient with prolonged VP shunt: A case report." Case Reports in Internal Medicine 4, no. 1 (2016): 4. http://dx.doi.org/10.5430/crim.v4n1p4.

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Background: Ventriculo-peritoneal shunt (VP shunt) surgery is the most widely used procedure in the treatment of hydrocephalus. Common complications post-VP shunt insertion are infection, mechanical failure, as well as functional complications such as overor underdrainage. Rarely, abdominal complications can present remotely after the time of VP shunt insertion. We found no reportsin the literature describing peritoneal exuberant mesothelial hyperplasia mimicking mesothelioma, clinically, radiologically, andpathologically in a setting of VP shunt.Case: A 22-year-old female with a history of T

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Goldsmith, Dayna A., and John M. Adaska. "Bovine cardiac mesothelial hyperplasia: a common incidental finding in adult cattle." Journal of Veterinary Diagnostic Investigation 32, no. 1 (2019): 65–69. http://dx.doi.org/10.1177/1040638719894552.

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Cardiac mesothelial hyperplasia forming pale plaque lesions on the epicardial surface is a common incidental finding in the hearts of aged humans. A similar phenomenon with a more papillary appearance has also been reported as an incidental finding in dogs and mice. These lesions are believed to occur in response to friction between the epicardium and overlying pericardium. We investigated this lesion in adult cattle, a phenomenon that has been associated with bovine leukemia virus infection and epicardial lymphoma. We examined 73 hearts from adult cattle, predominantly of dairy breeds: 53 fro

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Nicolas, Marlo M., Alia Nazarullah, and Jaishree S. Jagirdar. "Nodular Histiocytic and Mesothelial Hyperplasia." International Journal of Surgical Pathology 19, no. 6 (2011): 781–82. http://dx.doi.org/10.1177/1066896911418644.

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Walley, Virginia M., John P. Veinot, Henry Tazelaar, and Richard W. Courtice. "Lesions Described as Nodular Mesothelial Hyperplasia." American Journal of Surgical Pathology 23, no. 8 (1999): 994. http://dx.doi.org/10.1097/00000478-199908000-00024.

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10

Ordóñez, Nelson G., Jae Y. Ro, and Alberto G. Ayala. "Lesions Described as Nodular Mesothelial Hyperplasia." American Journal of Surgical Pathology 23, no. 8 (1999): 994. http://dx.doi.org/10.1097/00000478-199908000-00025.

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Oparka, Richard, W. Glenn McCluggage, and C. Simon Herrington. "Peritoneal mesothelial hyperplasia associated with gynaecological disease: a potential diagnostic pitfall that is commonly associated with endometriosis." Journal of Clinical Pathology 64, no. 4 (2011): 313–18. http://dx.doi.org/10.1136/jcp.2010.086074.

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AimsTo describe the clinicopathological features of florid peritoneal mesothelial hyperplasia associated with gynaecological disease.MethodsReview of a series of 44 cases where there was significant peritoneal mesothelial proliferation, usually on the surface of the ovary, which resulted in diagnostic problems, often including a consideration of malignancy.ResultsFlorid mesothelial proliferation was associated with a variety of benign and malignant lesions, most commonly endometriosis. The most characteristic morphological appearance was that of small bland tubules and nests and cords of cells

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Fischer, Edgar G., and Shweta Agarwal. "Florid Mesothelial Hyperplasia Associated with Abdominal Wall Endometriosis Mimicking Invasive Carcinoma." Case Reports in Pathology 2021 (November 28, 2021): 1–4. http://dx.doi.org/10.1155/2021/3439700.

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Florid mesothelial hyperplasia typically occurs in the pelvis, abdomen, or chest associated with an underlying neoplastic or inflammatory process. These lesions are of clinical significance because they can mimic a neoplasm. Early reports were published in the 1970s, but only a few case series of such lesions have been published in the gynecologic pathology literature. Here, we report a case of florid mesothelial hyperplasia with an infiltrative growth pattern, mimicking an invasive carcinoma. The lesion was associated with endometriosis forming a mass lesion in the abdominal wall. Histologica

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13

Colby, T. V. "231 Atypical mesothelial cell proliferations: Separating mesothelioma from reactive mesothelial hyperplasia." Lung Cancer 54 (October 2006): S56. http://dx.doi.org/10.1016/s0169-5002(07)70307-0.

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14

AbdullGaffar, Badr, and Lakshmiah G. Raman. "Collagenous Spherulosis in Well-Differentiated Papillary Mesothelioma in a Female With Multilocular Peritoneal Inclusion Cysts." International Journal of Surgical Pathology 27, no. 4 (2018): 427–31. http://dx.doi.org/10.1177/1066896918816815.

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Multilocular peritoneal inclusion cysts are mesothelial tumor-like lesions with or without small foci of florid papillary mesothelial hyperplasia that might simulate serous epithelial papillary lesions or well-differentiated papillary mesothelioma (WDPM) of the peritoneum. The papillary cores in papillary mesothelial hyperplasia and in WDPM display a variety of different histomorphologic features. To our knowledge, collagenous spherulosis in WDPM was not previously described or illustrated in the literature. Collagen spherules have been described in several miscellaneous benign and malignant l

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15

Clement, Philip B., and Robert H. Young. "Florid Mesothelial Hyperplasia Associated with Ovarian Tumors." International Journal of Gynecological Pathology 12, no. 1 (1993): 51–58. http://dx.doi.org/10.1097/00004347-199301000-00007.

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16

Yokoi, Toyoharu, and Eugene J. Mark. "Atypical mesothelial hyperplasia associated with bronchogenic carcinoma." Human Pathology 22, no. 7 (1991): 695–99. http://dx.doi.org/10.1016/0046-8177(91)90292-w.

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17

Chikkamuniyappa, Shylashree, Jennifer Herrick, and Jaishree S. Jagirdar. "Nodular histiocytic/mesothelial hyperplasia: a potential pitfall." Annals of Diagnostic Pathology 8, no. 3 (2004): 115–20. http://dx.doi.org/10.1016/j.anndiagpath.2004.03.001.

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18

Kirejczyk, Shannon G., Anne L. Burnum, Corrie C. Brown, Kaori Sakamoto, and Daniel R. Rissi. "Cardiac mesothelial papillary hyperplasia in four dogs." Journal of Veterinary Diagnostic Investigation 30, no. 3 (2018): 479–82. http://dx.doi.org/10.1177/1040638717753964.

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Mesothelial papillary hyperplasia (MPH) has been described as an incidental finding on the epicardial surface of clinically normal laboratory Beagle dogs. We describe MPH in 4 dogs diagnosed with acute cardiac tamponade (1 case) or chronic cardiac disease (3 cases). Cardiac MPH appeared as distinct, soft, irregular villous plaques on the epicardial surface of the auricles and occasionally the ventricles. Histologically, areas of MPH were composed of multiple papillary fronds arising from the epicardial surface and projecting into the pericardial space. Fronds were covered by cuboidal and occas

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19

Cabibi, Daniela, Giorgio Lo Iacono, Francesco Raffaele, et al. "Nodular histiocytic/mesothelial hyperplasia as consequence of chronic mesothelium irritation by subphrenic abscess." Future Oncology 11, no. 24s (2015): 51–55. http://dx.doi.org/10.2217/fon.15.287.

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20

Aoki, Shigehisa, Junichi Makino, Akinori Nagashima, et al. "Fluid Flow Stress Affects Peritoneal Cell Kinetics: Possible Pathogenesis of Peritoneal Fibrosis." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 31, no. 4 (2011): 466–76. http://dx.doi.org/10.3747/pdi.2010.00157.

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BackgroundPeritoneal fibrosis is an essential precursor condition to the development of encapsulating peritoneal sclerosis (EPS). This serious complication leads to a high mortality rate in peritoneal dialysis (PD) patients. Although several factors, including highly concentrated glucose in the dialysis solution, are believed to be potent agents for peritoneal fibrosis, the underlying mechanism remains unclear. During PD, the dialysis solution continuously generates fluid flow stress to the peritoneum under peristalsis and body motion. Fluid flow stress has been implicated as playing a critica

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21

Lopes, M., M. Cosentino, G. Magro, and V. Cosentino. "Reactive Pseudo-Glandular Mesothelial Hyperplasia of Testis Tunica Vaginalis: A Potential Diagnostic Pitfall." Urologia Journal 70, no. 1-4 (2003): 35–37. http://dx.doi.org/10.1177/039156030307001-407.

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The authors report a case of reactive pseudo-glandular mesothelial hyperplasia in the context of aspecific chronic vaginalitis. The distinctive clinical, morphological and immunohistochemical features as well as the differential diagnoses are described.

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22

Berg, Kyra B., Peter D. Liebling, Melanie J. Kubik, et al. "Pleural nodular mesothelial/histiocytic hyperplasia associated with syphilis." Human Pathology: Case Reports 13 (September 2018): 18–20. http://dx.doi.org/10.1016/j.ehpc.2018.03.005.

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23

Plesker, Roland, Kernt Köhler, Susanne von Gerlach, Klaus Boller, Markus Vogt, and Inke S. Feder. "Reactive mesothelial hyperplasia mimicking mesothelioma in an African green monkey (<i>Chlorocebus aethiops</i>)." Primate Biology 7, no. 1 (2020): 5–12. http://dx.doi.org/10.5194/pb-7-5-2020.

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Abstract. A spontaneous reactive mesothelial hyperplasia occurred in a female, 15.7-year-old African green monkey (grivet; Chlorocebus aethiops). At necropsy, massive effusions were found in the abdomen, the thorax, and the pericardium. Additionally, multiple small, beige-gray nodules were detected on the serosal surfaces of the abdominal organs. Histopathologically, the mesothelial cells resembled the epithelioid subtype of a mesothelioma, but no infiltrative or invasive growth could be demonstrated. The mesothelial cells on the thoracis, liver, and intestinal serosa were accompanied by chron

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24

Burke, Allen, and Teklu Legesse. "Nivolumab-Induced Peritonitis With Mesothelial Hyperplasia Mimicking Metastatic Mesothelioma." AJSP: Reviews and Reports 27, no. 3 (2022): 98–102. http://dx.doi.org/10.1097/pcr.0000000000000503.

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25

Lee, Sang Do, Woo Sung Kim, Yong Hoon Kim, et al. "Diagnostic Significance of Mesothelial Hyperplasia in Pleural Biopsy Specimen." Tuberculosis and Respiratory Diseases 35, no. 3 (1988): 181–86. http://dx.doi.org/10.4046/trd.1988.35.3.181.

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26

Kradin, Richard L., and Eugene J. Mark. "Distinguishing benign mesothelial hyperplasia from neoplasia: a practical approach." Seminars in Diagnostic Pathology 23, no. 1 (2006): 4–14. http://dx.doi.org/10.1053/j.semdp.2006.06.005.

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27

Lagana, Stephen M., Robert N. Taub, and Alain C. Borczuk. "Utility of Glucose Transporter 1 in the Distinction of Benign and Malignant Thoracic and Abdominal Mesothelial Lesions." Archives of Pathology & Laboratory Medicine 136, no. 7 (2012): 804–9. http://dx.doi.org/10.5858/arpa.2011-0219-oa.

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Context.—Malignant mesothelioma, of either peritoneum or pleura, is an uncommon cancer. The diagnosis is often difficult to make, in part because of the overlapping morphology of reactive and malignant mesothelial cells. Glucose transporter 1 (GLUT-1) is a glucose transporter typically found on erythrocytes, which is aberrantly expressed in various carcinomas. It has recently been reported as specific and sensitive in discriminating malignant pleural mesothelioma from reactive hyperplasia. The application of GLUT-1 staining in peritoneal mesothelioma has not been fully explored. Objective.—To

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28

Aydin, Hasan Basri, Anne Chen, and Hwajeong Lee. "Nodular histiocytic/mesothelial hyperplasia, a benign entity posing diagnostic challenge." Human Pathology Reports 28 (June 2022): 300613. http://dx.doi.org/10.1016/j.hpr.2022.300613.

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Lee, Stephen, Peter B. Illei, Jeong S. Han, and Jonathan I. Epstein. "Florid Mesothelial Hyperplasia of the Tunica Vaginalis Mimicking Malignant Mesothelioma." American Journal of Surgical Pathology 38, no. 1 (2014): 54–59. http://dx.doi.org/10.1097/pas.0b013e31829ab20e.

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30

Suarez-Vilela, D., and F. M. Izquierdo-Garcia. "Nodular histiocytic/mesothelial hyperplasia: a process mediated by adhesion molecules?" Histopathology 40, no. 3 (2002): 299–300. http://dx.doi.org/10.1046/j.1365-2559.2002.1363d.x.

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31

Jaiswal, Neha, Jayant Makrande, and Sunita Vagha. "Epithelial Membrane Antigen, Vimentin, Desmin, Calretinin, E-Cadherin on Cell Block Preparations to Distinguish Well Differentiated Adenocarcinoma from Benign, Reactive, Atypical Mesothelial Cells." Journal of Evolution of Medical and Dental Sciences 10, no. 18 (2021): 1302–8. http://dx.doi.org/10.14260/jemds/2021/275.

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BACKGROUND Inconclusive cytomorphology often results due to failure to distinguish between adenocarcinoma cells from benign, reactive, atypical mesothelial cells in effusion specimens. To resolve such dilemmas, auxiliary techniques like immunohistochemistry were utilised to reach a definitive diagnosis for better treatment and management of patients. We wanted to compare cytodiagnosis achieved on cell block preparations with the cytodiagnosis on conventional smear and perform immunohistochemistry for epithelial membrane antigen (EMA), calretinin, desmin, vimentin and E-cadherin on cell block p

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32

Figueredo-Silva, Jose, Joaquim Norões, and Gerusa Dreyer. "Lymphatic Endothelial Cell in Endemic Bancroftian Filariasis: A Focus on the Lymphatics of the Tunica Vaginalis Testis." Journal of Tropical Medicine 2018 (2018): 1–14. http://dx.doi.org/10.1155/2018/5134670.

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Background. In endemic areas, lymphangiectasia is the fundamental alteration to liveWuchereria bancroftiadult worms which, in adult males, are usually found in the lymphatic vessels of the spermatic cord; accordingly, hydrocele/filaricele is the most common clinical manifestation of bancroftian filariasis. The pathogenic role of the lymphatic endothelial cells (LECs) and the status of mesothelial cells (MCs) samples of the parietal layer (PL) of the tunica vaginalis testis were examined.Methods. The PL of thirty-two patients, excised for different reasons, was examined by histology and immunoh

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33

Suarez, Joelle S., Giovanni Gaudino, Tak W. Mak, Michele Carbone, and Haining Yang. "Abstract 5919: The significant role of HMGB1 in mesothelial cells in contributing to the mesothelioma development induced by asbestos." Cancer Research 83, no. 7_Supplement (2023): 5919. http://dx.doi.org/10.1158/1538-7445.am2023-5919.

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Abstract Diffuse Malignant mesothelioma is a very aggressive cancer that is related to asbestos exposure. We found previously that following asbestos deposition in the pleura and in the peritoneum, mesothelial cells release HMGB1 that attract granulocytes and macrophages that, in turn, secrete HMGB1. It was unknown whether the primary source of HMGB1 that drives the inflammatory process caused by asbestos, which may ensue in mesothelioma, derives from the mesothelial cells exposed to asbestos or from the granulocytes and macrophages. To study separately the contribution of mesothelial cells an

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34

Churg, Andrew, and Francoise Galateau-Salle. "The Separation of Benign and Malignant Mesothelial Proliferations." Archives of Pathology & Laboratory Medicine 136, no. 10 (2012): 1217–26. http://dx.doi.org/10.5858/arpa.2012-0112-ra.

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Context.—The separation of benign from malignant mesothelial proliferations is crucial to patient management but is often a difficult problem for the pathologist. Objective.—To review the pathologic features that allow separation of benign from malignant mesothelioma proliferations, with an emphasis on new findings. Data Sources.—Literature review and experience of the authors. Conclusions.—Invasion is still the most reliable indicator of malignancy. The distribution and amount of proliferating mesothelial cells are important in separating benignity from malignancy, and keratin stains can be v

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35

Ordóñez, Nelson G., Jae Y. Ro, and Alberto G. Ayala. "Lesions Described as Nodular Mesothelial Hyperplasia Are Primarily Composed of Histiocytes." American Journal of Surgical Pathology 22, no. 3 (1998): 285–92. http://dx.doi.org/10.1097/00000478-199803000-00002.

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Scurry, J., and M. A. Duggan. "Malignant mesothelioma eight years after a diagnosis of atypical mesothelial hyperplasia." Journal of Clinical Pathology 52, no. 7 (1999): 535–37. http://dx.doi.org/10.1136/jcp.52.7.535.

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Chen, Hong-Jie, Dong-Hai Li, and Jun Zhang. "A case of spermatic cord cyst with nodular histiocytic/mesothelial hyperplasia." Asian Journal of Andrology 19, no. 4 (2017): 505. http://dx.doi.org/10.4103/1008-682x.194818.

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38

YAMADA, Naoaki, Satomi HASHIMOTO, Yuki TOMONARI, et al. "Bacterial Pleuritis with Thickened Mesothelial Hyperplasia in a Young Beagle Dog." Journal of Toxicologic Pathology 26, no. 3 (2013): 313–17. http://dx.doi.org/10.1293/tox.26.313.

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Prasad, Ashish, Diana Olsen, and P. S. Sriram. "Malignant Mesothelioma Presenting as a Gradually Enlarging Pneumothorax." Case Reports in Pulmonology 2013 (2013): 1–3. http://dx.doi.org/10.1155/2013/374960.

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Malignant mesothelioma is an extremely aggressive tumor arising from the pleura with median survival of approximately 9–12 months. It can rarely present as a spontaneous pneumothorax. Less than 35 cases of malignant mesothelioma presenting as spontaneous pneumothorax have been reported in the literature. Pathology may show florid mesothelial hyperplasia. We herein report a case of mesothelioma presenting as a pneumothorax that gradually enlarged over a one-year period and also review the relevant literature.

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Bagwan, Izhar, Nirmala A. Jambhekar, Ratnaprabha K. Ghodke, and Uma Bansal. "Florid Tubulopapillary Mesothelial Hyperplasia: A Lesion Mistaken for Carcinoma—a Case Report." Journal of Gynecologic Surgery 21, no. 1 (2005): 25–28. http://dx.doi.org/10.1089/gyn.2005.21.25.

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Tunio, Mutahir A., Mushabbab AlAsiri, Syed Azfer Husain, Nagoud Mohamed Omar Ali, and Shomaila S. Akbar. "Atypical mesothelial hyperplasia mimicking mesothelioma in patient with metastatic papillary carcinoma of thyroid." El Mednifico Journal 2, no. 2 (2014): 148. http://dx.doi.org/10.18035/emj.v2i2.110.

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Ruffolo, Robert, and Saul Suster. "Diffuse Histiocytic Proliferation Mimicking Mesothelial Hyperplasia in Endocervicosis of the Female Pelvic Peritoneum." International Journal of Surgical Pathology 1, no. 2 (1993): 101–5. http://dx.doi.org/10.1177/106689699300100202.

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43

Herrera Kok, Johnn Henry, Emiliano Honrado Franco, María Concepción Álvarez Cañas, et al. "Mesothelial hyperplasia: Presentation of a case of rectal adenocarcinoma with “diffuse peritoneal carcinomatosis”." European Journal of Surgical Oncology 49, no. 2 (2023): e203-e204. http://dx.doi.org/10.1016/j.ejso.2022.11.559.

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Herrera Kok, Johnn Henry, Emiliano Honrado Franco, María Concepción Álvarez Cañas, et al. "Mesothelial hyperplasia: Presentation of a case of rectal adenocarcinoma with “diffuse peritoneal carcinomatosis”." European Journal of Surgical Oncology 49, no. 2 (2023): e195. http://dx.doi.org/10.1016/j.ejso.2022.11.538.

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Bruno, Rossella, Greta Alì, Riccardo Giannini, et al. "Malignant pleural mesothelioma and mesothelial hyperplasia: A new molecular tool for the differential diagnosis." Oncotarget 8, no. 2 (2016): 2758–70. http://dx.doi.org/10.18632/oncotarget.13174.

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Chan, John K. C., K. T. Loo, Bryan K. C. Yau, and S. Y. Lam. "Nodular Histiocytic/Mesothelial Hyperplasia: A Lesion Potentially Mistaken for a Neoplasm in Transbronchial Biopsy." American Journal of Surgical Pathology 21, no. 6 (1997): 658–63. http://dx.doi.org/10.1097/00000478-199706000-00005.

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47

Slater, Nicholas D., Geoffrey H. Cope, and Andrew T. Raftery. "Mesothelial Hyperplasia in Response to Peritoneal Dialysis Fluid A Morphometric Study in the Rat." Nephron 58, no. 4 (1991): 466–71. http://dx.doi.org/10.1159/000186481.

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48

Chung, Yumin, Rehman Abdul, Se Min Jang, Joong Sub Choi, and Kiseok Jang. "Pelvic Nodular Histiocytic and Mesothelial Hyperplasia in a Patient with Endometriosis and Uterine Leiomyoma." Journal of Pathology and Translational Medicine 50, no. 5 (2016): 397–400. http://dx.doi.org/10.4132/jptm.2016.01.11.

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49

Athanazio, Daniel Abensur, Andrea de Oliveira Cruz, Luiza Oliveira Barbosa, Isabela Soares Pimenta, and Nathanael Pinheiro de Freitas. "Florid mesothelial hyperplasia of the tunica vaginalis: report of two cases with immunohistochemical findings." International Urology and Nephrology 51, no. 6 (2019): 971–73. http://dx.doi.org/10.1007/s11255-019-02153-x.

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Orlandi, Riccardo, Francesca Bono, Diego Luigi Cortinovis, et al. "Sneaky Diagnosis of Pleural Malignant Mesothelioma in Thoracic Surgery: All That Glitters Is Not Gold." Journal of Clinical Medicine 11, no. 11 (2022): 3225. http://dx.doi.org/10.3390/jcm11113225.

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Malignant Pleural Mesothelioma (MPM) is a highly aggressive disease whose diagnosis could be challenging and confusing. It could occur with atypical presentations on every examined level. Here, we present three unconventional cases of the complex diagnostic process of MPM that we have experienced during routine practice: a patient with reactive mesothelial hyperplasia mimicking MPM, an unexpected presentation of MPM with persistent unilateral hydropneumothorax, a rare case of MPM in situ. Then, we review the relevant literature on each of these topics. Definitive biomarkers to confidently dist

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