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Bibliographies thématiques / Mesothelioma, primary cilium, hedgehog pathway

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Littérature scientifique sur le sujet « Mesothelioma, primary cilium, hedgehog pathway »

Auteur : Grafiati

Publié le 14 mars 2023

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Articles de revues sur le sujet "Mesothelioma, primary cilium, hedgehog pathway"

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Barbarino, Marcella, Maria Bottaro, Laura Spagnoletti, et al. "Analysis of Primary Cilium Expression and Hedgehog Pathway Activation in Mesothelioma Throws Back Its Complex Biology." Cancers 14, no. 21 (2022): 5216. http://dx.doi.org/10.3390/cancers14215216.

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The primary cilium (PC) is a sensory organelle present on the cell surface, modulating the activity of many pathways. Dysfunctions in the PC lead to different pathologic conditions including cancer. Hedgehog signaling (Hh) is regulated by PC and the loss of its control has been observed in many cancers, including mesothelioma. Malignant pleural mesothelioma (MPM) is a fatal cancer of the pleural membranes with poor therapeutic options. Recently, overexpression of the Hh transcriptional activator GL1 has been demonstrated to be associated with poor overall survival (OS) in MPM. However, unlike

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Ma, Ming, Emilie Legué, Xin Tian, Stefan Somlo, and Karel F. Liem. "Cell-Autonomous Hedgehog Signaling Is Not Required for Cyst Formation in Autosomal Dominant Polycystic Kidney Disease." Journal of the American Society of Nephrology 30, no. 11 (2019): 2103–11. http://dx.doi.org/10.1681/asn.2018121274.

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BackgroundPKD1 or PKD2, the two main causal genes for autosomal dominant polycystic kidney disease (ADPKD), encode the multipass transmembrane proteins polycystin-1 (PC1) and polycystin-2 (PC2), respectively. Polycystins localize to the primary cilium, an organelle essential for cell signaling, including signal transduction of the Hedgehog pathway. Mutations in ciliary genes that build and maintain the cilium also cause renal cystic disease through unknown pathways. Although recent studies have found alterations in Hedgehog signaling in ADPKD-related models and tissues, the relationship betwee

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Gómez, Arianna Ericka, Angela K. Christman, Julie Craft Van De Weghe, Malaney Finn, and Dan Doherty. "Systematic analysis of cilia characteristics and Hedgehog signaling in five immortal cell lines." PLOS ONE 17, no. 12 (2022): e0266433. http://dx.doi.org/10.1371/journal.pone.0266433.

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Dysfunction of the primary cilium, a microtubule-based signaling organelle, leads to genetic conditions called ciliopathies. Hedgehog (Hh) signaling is mediated by the primary cilium in vertebrates and is therefore implicated in ciliopathies; however, it is not clear which immortal cell lines are the most appropriate for modeling pathway response in human disease; therefore, we systematically evaluated Hh in five commercially available, immortal mammalian cell lines: ARPE-19, HEK293T, hTERT RPE-1, NIH/3T3, and SH-SY5Y. Under proper conditions, all of the cell lines ciliated adequately for our

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Jung, Bomi, Daniela Padula, Ingo Burtscher, et al. "Pitchfork and Gprasp2 Target Smoothened to the Primary Cilium for Hedgehog Pathway Activation." PLOS ONE 11, no. 2 (2016): e0149477. http://dx.doi.org/10.1371/journal.pone.0149477.

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Zhang, Boyan, Tenghan Zhuang, Qiaoyu Lin, et al. "Patched1–ArhGAP36–PKA–Inversin axis determines the ciliary translocation of Smoothened for Sonic Hedgehog pathway activation." Proceedings of the National Academy of Sciences 116, no. 3 (2018): 874–79. http://dx.doi.org/10.1073/pnas.1804042116.

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The Sonic Hedgehog (Shh) pathway conducts primarily in the primary cilium and plays important roles in cell proliferation, individual development, and tumorigenesis. Shh ligand binding with its ciliary membrane-localized transmembrane receptor Patched1 results in the removal of Patched1 from and the translocation of the transmembrane oncoprotein Smoothened into the cilium, leading to Shh signaling activation. However, how these processes are coupled remains unknown. Here, we show that the Patched1–ArhGAP36–PKA–Inversin axis determines the ciliary translocation of Smoothened. We find that Patch

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Yuan, Gongjie, Gurpreet Singh, Serafine Chen, et al. "Cleft Palate and Aglossia Result from Perturbations in Wnt and Hedgehog Signaling." Cleft Palate-Craniofacial Journal 54, no. 3 (2017): 269–80. http://dx.doi.org/10.1597/15-178.

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Objective The objective of this study was to explore the molecular basis for cleft secondary palate and arrested tongue development caused by the loss of the intraflagellar transport protein, Kif3a. Design Kif3a mutant embryos and their littermate controls were analyzed for defects in facial development at multiple stages of embryonic development. Histology was employed to understand the effects of Kif3a deletion on palate and tongue development. Various transgenic reporter strains were used to understand how deletion of Kif3a affected Hedgehog and Wnt signaling. Immunostaining for structural

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Hoogendoorn, Sascha. "Small Molecules Targeting the Hedgehog Pathway: From Phenotype to Mechanistic Understanding." CHIMIA International Journal for Chemistry 74, no. 9 (2020): 652–58. http://dx.doi.org/10.2533/chimia.2020.652.

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Since the beginning of 2019, the Hoogendoorn lab is active at the University of Geneva. We are a Chemical Biology lab and our research focuses on the Hedgehog (Hh) signalling pathway and the primary cilium, a small cellular organelle which corrects structure and function, is required to conduct the Hh signal. Ciliary Hh signalling plays an important role in embryonic development, and its dysregulation consequently results in developmental disorders as well as a variety of cancers. We use an interdisciplinary approach, ranging from organic chemistry to cell biology and genetics, to develop chem

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Kiprilov, Enko N., Aashir Awan, Romain Desprat, et al. "Human embryonic stem cells in culture possess primary cilia with hedgehog signaling machinery." Journal of Cell Biology 180, no. 5 (2008): 897–904. http://dx.doi.org/10.1083/jcb.200706028.

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Human embryonic stem cells (hESCs) are potential therapeutic tools and models of human development. With a growing interest in primary cilia in signal transduction pathways that are crucial for embryological development and tissue differentiation and interest in mechanisms regulating human hESC differentiation, demonstrating the existence of primary cilia and the localization of signaling components in undifferentiated hESCs establishes a mechanistic basis for the regulation of hESC differentiation. Using electron microscopy (EM), immunofluorescence, and confocal microscopies, we show that pri

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Ku, Pei-I., Jamuna S. Sreeja, Benjamin R. Myers, and Radhika Subramanian. "Real time imaging of the trafficking of a Hedgehog pathway kinesin in the primary cilium." Biophysical Journal 121, no. 3 (2022): 85a. http://dx.doi.org/10.1016/j.bpj.2021.11.2286.

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Girardet, Laura, Agathe Bernet, Ezéquiel Calvo, et al. "Hedgehog signaling pathway regulates gene expression profile of epididymal principal cells through the primary cilium." FASEB Journal 34, no. 6 (2020): 7593–609. http://dx.doi.org/10.1096/fj.202000328r.

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Thèses sur le sujet "Mesothelioma, primary cilium, hedgehog pathway"

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Marcella, Barbarino. "PRIMARY CILIUM LOSS IN ADVANCED MESOTHELIOMA CORRELATES WITH CONSTITUTIVE GLI1 OVEREXPRESSION." Doctoral thesis, Università di Siena, 2021. http://hdl.handle.net/11365/1161108.

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Malignant mesothelioma is an aggressive cancer of the membranes covering the lung and chest cavity (pleura), or the abdomen (peritoneum), mainly linked to asbestos exposure. It is characterized by high intrinsic heterogeneity, diagnosis in the late stages and a high immunosuppressive microenvironment. In the past years many agents have been evaluated for use in mesothelioma but with modest results so that the prognosis remains poor. Recently, in light of the promising results achieved in other cancers, the targeting of the Hedgehog-GLI (HH-GLI) pathway has been investigated as possible new th

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Actes de conférences sur le sujet "Mesothelioma, primary cilium, hedgehog pathway"

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Senicourt, Blanche. "Abstract 4430: Implication of the primary cilium in the Hedgehog pathway in colorectal cancer cells." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-4430.

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Moran, Emma C., Pedro M. Baptista, Kenichiro Nishii, David Wasnick, Shay Soker, and Jessica L. Sparks. "Expression of Primary Cilia on Liver Stem and Progenitor Cells: Potential Role for Mechanosensing in Liver Development." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14122.

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The primary cilium is a non-motile organelle that projects out from the plasma membrane of many cell types in the body. It consists of an axoneme with microtubules arranged in a 9+0 arrangement that extends from the mother centriole contained within the basal body. Once thought to be a non-essential organelle, it is now known that primary cilia have an important role in embryonic and post-natal development, as well as maintenance of adult tissues. Mutations affecting primary ciliary development result in a class of serious diseases known as ciliopathies [1, 2]. Recent research suggests that th

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