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Littérature scientifique sur le sujet « Metformin HCL »

Auteur : Grafiati

Publié le 2 juin 2025

Mis à jour le 31 juillet 2025

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Articles de revues sur le sujet "Metformin HCL"

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Nugrahani, Ilma, Sukmadjaja Asyarie, and Belda Nurmeyna. "Karakterisasi Padatan Mikrosfer Metformin HCl / Alginat-Ca2+ Paut Silang." Acta Pharmaceutica Indonesia 38, no. 1 (2013): 19–25. http://dx.doi.org/10.5614/api.v38i1.5199.

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Telah dilakukan karakterisasi padatan metformin HCl - natrium alginat-Ca2+ paut silang untuk memprediksi kemampuannya menahan pelepasan bahan aktif dikaitkan dengan sifat kristalinitas dan higroskopisitasnya. Karakterisasi mikrosfer dilakukan dengan membandingkan mikrosfer berisi metformin HCl (MDM) dengan persen penjeratan bahan aktif tertinggi yang diperoleh dari optimasi formulasi sebelumnya, mikrosfer tanpa metformin HCl (MTM), dan campuran fisik dari natrium alginat dengan metformin HCl (CF). Selanjutnya setiap sampel dibagi menjadi dua kelompok, yaitu kelompok yang disimpan pada desikato

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Karim, Chowdhury Forhadul, Mohammod Jahidul Islam, and Shamima Abdul Rahman. "Metformin HCl Oral Preparation Exhibits Anticancer Activity In-vitro in a Human Non-small Cell Lung Tumour Cell Line." Malaysian Journal of Medicine and Health Sciences 19, no. 3 (2023): 64–71. http://dx.doi.org/10.47836/mjmhs.19.3.9.

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Introduction: The most common variety of lung cancer is non–small cell lung cancer (NSCLC) accounting for 84% of new cases. Surgery, chemotherapy and radiation are the primary treatment option. Metformin has recently been demonstrated to have an anti-tumour impact on various cancer cells. The goal of this investigation was to determine the growth inhibitory, antiproliferative, cytotoxic, apoptotic and cell cycle arrest properties of metformin HCl oral tablets on the A549 lung carcinoma cell line. Methods: The cells were treated with different dosages of an oral preparation of metformin, with u

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Imwa, Putra, and Kusumawati Igaw. "THE USE OF CLINOPTILOLITES AS CARRIER OF METFORMIN HYDROCHLORIDE IN DRUG DELIVERY SYSTEM: IN VITRO DRUG RELEASE STUDY." Asian Journal of Pharmaceutical and Clinical Research 11, no. 11 (2018): 285. http://dx.doi.org/10.22159/ajpcr.2018.v11i11.24366.

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Objective: As an antidiabetic drug, metformin hydrochloride (HCl) has been well known to possess low oral bioavailability and short half-life. In this study, we prepared the drug delivery system (DDS) of metformin HCl and clinoptilolite as its carrier. The in vitro drug release profile was further investigated.Methods: DDS was made by encapsulating metformin HCl on clinoptilolite using the wet impregnation method at various pH and initial concentration of metformin HCl. Fourier transform infrared spectrometer (FTIR), X-ray diffractometer (XRD), and N2 Sorption Analyzer were used to characteriz

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Darusman, Fitrianti, Taufik Muhammad Fakih, and Gina Fuji Nurfarida. "Identification of the Glimepiride and Metformin Hydrochloride Physical Interaction in Binary Systems." Borneo Journal of Pharmacy 4, no. 2 (2021): 110–16. http://dx.doi.org/10.33084/bjop.v4i2.1826.

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Glimepiride is often combined with metformin HCl as an oral antidiabetic in type II diabetes mellitus, which provides a complementary and synergistic effect with multiple targets for insulin secretion. Glimepiride includes class II of BCS, which solubility practically insoluble in water but high permeability, which will impact the drug's small bioavailability. In contrast, metformin HCl includes class III of BCS, which has a high solubility in water, but low permeability is absorbed approximately 50-60% in the digestive tract given orally. The co-crystallization method can be used to improve t

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T, Hemant Kumar, and Gowri Sankar D. "RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF METFORMIN HCL AND CANAGLIFLOZIN IN PHARMACEUTICAL FORMULATION." INDIAN DRUGS 58, no. 06 (2021): 49–59. http://dx.doi.org/10.53879/id.58.06.10607.

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A simple, specific, accurate, precise and stability-indicating RP-HPLC method was developed and validated for the simultaneous estimation of metformin HCl and canagliflozin in pharmaceutical formulation. The method was developed using the Altima C8 column (150 ×4.6 mm, 0.5 μm) with a mobile phase consisting of acetonitrile and 0.1 % orthophosphoric acid in water (62:38 %V/V) with a flow rate of 1 mL/min. Detection was carried out at 254 nm using a PDA detector. The retention time for metformin HCl and canagliflozin was found to be 2.282 and 3.339 min, respectively. The proposed method was vali

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Agus Andrie, Agus, and Anis Yohana Chaerunisa. "REVIEW: PENGGUNAAN MATRIKS PADA SISTEM PELEPASAN EXTENDED RELEASE SEDIAAN TABLET METFORMIN HCL." Medical Sains : Jurnal Ilmiah Kefarmasian 7, no. 3 (2022): 523–34. http://dx.doi.org/10.37874/ms.v7i3.411.

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Terapi farmakologi lini pertama pada pasien diabetes melitus terutama diabetes melitus tipe II pada pasien obesitas dan yang memiliki fungsi ginjal normal adalah metformin. Namun, metformin dengan sistem pelepasan segera ditemukan memiliki banyak kelemahan seperti menimbulkan efek samping dan rendahnya kepatuhan pasien. Untuk mengatasi hal tersebut, maka dikembangkan formulasi dengan pelepasan diperpanjang (extended release). Tujuan penulisan review artikel ini adalah memberikan informasi dan gambaran mengenai matriks yang dapat digunakan untuk formulasi tablet metfomin HCl dengan sistem pelep

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Neha, Mochi1 Dr. Rajesh Patel*2. "A Novel RP-HPLC-DAD Method Development and Validation for The Concurrent Quantification of Empagliflozin, Linagliptin and Metformin HCl In a Fixed Dose Combination." International Journal of Pharmaceutical Sciences 3, no. 1 (2025): 431–43. https://doi.org/10.5281/zenodo.14609205.

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Purpose: For the simultaneous evaluation of Empagliflozin, Linagliptin, and Metformin HCl in a fixed dose combination, a recently established, precise, fast, accurate, and reliable   RP-HPLC method has been developed and validated.  Methods: Using a Water C18 column (250 mm x 4.6 mm id, 5µ particle size) and an optimized mobile phase combination of 1% orthophosphoric acid: ACN (40:60, %v/v) at a flow rate of 1.0 mL/min, isocratic separation was accomplished using the recommended method. The detection wavelength was determined to be 251 nm. Results: Empagliflozin, Linaglipt

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Kharbade, Sukanya, Alpana Asnani, and Kumar Pratyush. "Development and Validation of UV Spectrophotometric Method for Simultaneous Estimation of Metformin HCl and Repaglinide in Pharmaceutical Formulation." Journal of Drug Delivery and Therapeutics 9, no. 3 (2019): 344–47. http://dx.doi.org/10.22270/jddt.v9i3.2676.

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Objective: A new, simple, rapid, accurate and economical method have been developed for the simultaneous estimation of Metformin HCl and Repaglinide in formulation. Method: The absorbances of both the drugs were determined at 238 nm and at 294 nm. The linearity was observed in the concentration range of 2-100 µg/ml and 1-35 µg/ml for Metformin HCl and Repaglinide respectively. The method was validated as per ICH guidelines. Result: The recovery of Metformin and Repaglinide was found in the range of 98.24 ± 0.325 to 100.25 ± 0.756. Conclusion: The proposed method was accurate, reproducible and

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Hariyadi, Dewi Melani, Noorma Rosita, and Tiara Jeni Rosadi. "Effect of Total Amount of Metformin HCl on the Characteristics of Metformin-Ca Alginate Microspheres." JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA 5, no. 1 (2019): 13. http://dx.doi.org/10.20473/jfiki.v5i12018.13-19.

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Introduction: Metformin hydrochloride (metformin HCl) is an antidiabetic drug that is specifically used for type 2 diabetes mellitus (DM) and belongs to the biguanide antidiabetic drugs. Objective: The aim of this research was to determine the effect of total amount of metformin HCl on the characteristics of metformin HCl-Ca alginate microspheres using aerosolization technique. Methods: The total amount of metformin were 0.5 g (F1); 1 g (F2); 1.5 g (F3) and 2 g (F4). Drug was encapsulated into alginate and was crosslinked using CaCl2. Results: The results showed that drug loadings were 5.09%;

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Junejo, Shizma, Nasim Karim, Muhammad Sajid Abbas Jafri, and Muhammad Arif Razzak. "Clinical Efficacy and Safety of Metformin in Prediabetics." Journal of Saidu Medical College Swat 15, no. 2 (2025): 279–85. https://doi.org/10.52206/jsmc.2025.15.2.1002.

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Background: Prediabetes is defined as a state of abnormal glucose homeostasis, HbA1c 5.7% to 6.4% and fasting blood glucose 100 mg/dl to 125mg/dl. Mainstay of treatment in prediabetes is lifestyle changes. However if not controlled pharmacotherapy is added. Metformin HCL is a biguanide drug.Objectives: To evaluate clinical efficacy of metformin HCl with lifestyle modifications and to assess the adverse effects, safety profile and cost effectiveness of metformin in pre-diabetics. Materials and Methods: This randomized controlled clinical trial (RCT) was conducted at diabetic clinics of National

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Thèses sur le sujet "Metformin HCL"

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Dogra, Sanjeev. "A Chitosan–Polymer Hydrogel Bead System For A Metformin HCl Controlled Release Oral Dosage Form." University of Toledo Health Science Campus / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=mco1303179716.

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SPROULE, MICHAEL. "Spike train propagation in the axon of a visual interneuron, the descending contralateral movement detector of Locusta migratoria." Thesis, 2011. http://hdl.handle.net/1974/6830.

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Neurons perform complex computations, communications and precise transmissions of information in the form of action potentials (APs). The high level of heterogeneity and complexity at all levels of organization within a neuron and the functional requirement of highly permeable cell membranes leave neurons exposed to damage when energy levels are insufficient for the active maintenance of ionic gradients. When energy is limiting the ionic gradient across a neuron’s cell membrane risks being dissipated which can have dire consequences. Other researchers have advocated “generalized channel arrest

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Livres sur le sujet "Metformin HCL"

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Nath, Bipul, LilaKanta Nath, and Bhaskar Mazumder. Gastric Floating Microcapsules of Metformin HCl: Methods, Evaluation and Applications. LAP LAMBERT Academic Publishing, 2011.

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Chapitres de livres sur le sujet "Metformin HCL"

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Divya, Kumble. "Metformin HCL: Visible Spectrophotometric Determination in Pure and Dosage Forms." In Progress in Chemical Science Research Vol. 1. Book Publisher International (a part of SCIENCEDOMAIN International), 2022. http://dx.doi.org/10.9734/bpi/pcsr/v1/2147a.

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Chlup, Rudolf, Hana Zálešáková, Jiřina Gottwaldová, et al. "Outcomes of Type 2 Diabetes Management: One Center Experience 2015–2023." In Type 2 Diabetes in 2024 - From Early Suspicion to Effective Management [Working Title]. IntechOpen, 2024. http://dx.doi.org/10.5772/intechopen.1005206.

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The purpose of this chapter was (1) to identify the frequency of employing different kinds of medication (beta-stimulators, metformin, gliflozins, incretins and/or insulins, pioglitazone, statins, fibrates), (2) to assess global metabolic effectiveness of this medication in a walk-in diabetes center, and (3) to estimate frequency of HbA1c measurements in people admitted to hospital. Methods: In 200 people with T2D (age 24–95 y, 105 men) HbA1c, BM, BMI, blood pressure [BP], lipoproteins HDL, LDL, TAG, eGFR, proteinuria were assessed. Individual observation periods took in the range of 0.5–8.8 y

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Sfikas, Georgios, and Ioannis Valsamidis. "Therapeutic Approach to NAFLD-NASH." In Non-alcoholic Fatty Liver Disease - New-Insight and Glance Into Disease Pathogenesis [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.107487.

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Nonalcoholic fatty liver disease (NAFLD) and its progressive form nonalcoholic steatohepatitis (NASH) are the hepatic expression of metabolic syndrome and may lead to serious injury to the liver resulting in cirrhosis and hepatocellular carcinoma (HCC). Despite its seriousness, there is no definite treatment to address this life-threatening condition. Weight loss and exercise remain the cornerstone of the therapeutic treatment but also an array of medications can be used with varying degrees on liver inflammation and cirrhosis. There is also an increased risk of cardiovascular events connected

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Actes de conférences sur le sujet "Metformin HCL"

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Akmal, Khan, Hesham Hassabo, Gehan Botrus, et al. "Abstract 3594: Impact of metformin on HCC prognosis." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-3594.

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Silva, Vanessa Paiva, Adriana Cardoso Furtado, Juliana Santos Guariento, Júlia Andrade Ibiapina Parente, and Luisa de Sousa Medeiros. "ESTUDO DO USO OFF LABEL DA METFORMINA NO TRATAMENTO DE OBESIDADE: EFICÁCIA E EFEITOS ADVERSOS." In I Congresso Brasileiro de Saúde Pública On-line: Uma abordagem Multiprofissional. Revista Multidisciplinar em Saúde, 2021. http://dx.doi.org/10.51161/rems/2827.

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Introdução: A obesidade se dá por um maior acúmulo de gordura corporal, sendo uma doença multifatorial, com maior prevalência na população baixa renda, podendo ter o emprego da metformina para tratamento, que é hipoglicemiante usado nas diabetes tipo 1 e 2. Objetivo: Com isso, este trabalho tem objetivo analisar o uso da metformina no tratamento da obesidade. Material e métodos: Se trata de uma revisão integrativa, usando as bases de dados Scielo e Pubmed, com filtros “últimos 5 anos e ensaios clínicos”, e descritores ‘meftormina AND obesidade’, com inclusão de 10 artigos publicados de 2006 a

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Lin., I. P. "Abstract 3547: CEBPD induces apoptosis through autophagy in metformin-treated HCC." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-3547.

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