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Littérature scientifique sur le sujet « Microtubules »

Auteur : Grafiati

Publié le 4 juin 2021

Mis à jour le 9 juin 2025

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Articles de revues sur le sujet "Microtubules"

Ray, S., E. Meyhöfer, R. A. Milligan, and J. Howard. "Kinesin follows the microtubule's protofilament axis." Journal of Cell Biology 121, no. 5 (June 1, 1993): 1083–93. http://dx.doi.org/10.1083/jcb.121.5.1083.

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We tested the hypothesis that kinesin moves parallel to the microtubule's protofilament axis. We polymerized microtubules with protofilaments that ran either parallel to the microtubule's long axis or that ran along shallow helical paths around the cylindrical surface of the microtubule. When gliding across a kinesin-coated surface, the former microtubules did not rotate. The latter microtubules, those with supertwisted protofilaments, did rotate; the pitch and handedness of the rotation accorded with the supertwist measured by electron cryo-microscopy. The results show that kinesin follows a

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Ookata, K., S. Hisanaga, E. Okumura, and T. Kishimoto. "Association of p34cdc2/cyclin B complex with microtubules in starfish oocytes." Journal of Cell Science 105, no. 4 (August 1, 1993): 873–81. http://dx.doi.org/10.1242/jcs.105.4.873.

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The microtubular cytoskeleton exhibits a dramatic reorganization, progressing from interphase radial arrays to a mitotic spindle at the G2/M transition. Although this reorganization has been suspected to be caused by maturation promoting factor (MPF: p34cdc2/cyclin B complex), little is known about how p34cdc2 kinase controls microtubule networks. We provide evidence of the direct association of the p34cdc2/cyclin B complex with microtubules in starfish oocytes. Anti-cyclin B staining of detergent-treated oocytes, isolated asters and meiotic spindles revealed fluorescence associated with micro

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Lloyd, C. W., and B. Wells. "Microtubules are at the tips of root hairs and form helical patterns corresponding to inner wall fibrils." Journal of Cell Science 75, no. 1 (April 1, 1985): 225–38. http://dx.doi.org/10.1242/jcs.75.1.225.

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Root hairs have sometimes provided contradictory evidence for microtubule/microfibril parallelism. This tissue was re-examined using optimized conditions for the fixation, before immunofluorescence, of root hairs. In phosphate buffer, microtubules did not enter the apical tip of radish root hairs and were clearly fragmented. However, in an osmotically adjusted microtubule-stabilizing buffer, microtubules were observed within the apical dome and appeared unfragmented. Microtubules are not, therefore, absent from the region where new cell wall is presumed to be generated during tip growth. A spi

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Logan, Caitlin M., and A. Sue Menko. "Microtubules: Evolving roles and critical cellular interactions." Experimental Biology and Medicine 244, no. 15 (August 6, 2019): 1240–54. http://dx.doi.org/10.1177/1535370219867296.

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Microtubules are cytoskeletal elements known as drivers of directed cell migration, vesicle and organelle trafficking, and mitosis. In this review, we discuss new research in the lens that has shed light into further roles for stable microtubules in the process of development and morphogenesis. In the lens, as well as other systems, distinct roles for characteristically dynamic microtubules and stabilized populations are coming to light. Understanding the mechanisms of microtubule stabilization and the associated microtubule post-translational modifications is an evolving field of study. Appro

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Gittes, F., B. Mickey, J. Nettleton, and J. Howard. "Flexural rigidity of microtubules and actin filaments measured from thermal fluctuations in shape." Journal of Cell Biology 120, no. 4 (February 15, 1993): 923–34. http://dx.doi.org/10.1083/jcb.120.4.923.

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Microtubules are long, proteinaceous filaments that perform structural functions in eukaryotic cells by defining cellular shape and serving as tracks for intracellular motor proteins. We report the first accurate measurements of the flexural rigidity of microtubules. By analyzing the thermally driven fluctuations in their shape, we estimated the mean flexural rigidity of taxol-stabilized microtubules to be 2.2 x 10(-23) Nm2 (with 6.4% uncertainty) for seven unlabeled microtubules and 2.1 x 10(-23) Nm2 (with 4.7% uncertainty) for eight rhodamine-labeled microtubules. These values are similar to

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Sider, J. R., C. A. Mandato, K. L. Weber, A. J. Zandy, D. Beach, R. J. Finst, J. Skoble, and W. M. Bement. "Direct observation of microtubule-f-actin interaction in cell free lysates." Journal of Cell Science 112, no. 12 (June 15, 1999): 1947–56. http://dx.doi.org/10.1242/jcs.112.12.1947.

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Coordinated interplay of the microtubule and actin cytoskeletons has long been known to be crucial for many cellular processes including cell migration and cytokinesis. However, interactions between these two systems have been difficult to document by conventional approaches, for a variety of technical reasons. Here the distribution of f-actin and microtubules were analyzed in the absence of fixation using Xenopus egg extracts as an in vitro source of microtubules and f-actin, demembranated Xenopus sperm to nucleate microtubule asters, fluorescent phalloidin as a probe for f-actin, and fluores

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Cassimeris, L., C. L. Rieder, G. Rupp, and E. D. Salmon. "Stability of microtubule attachment to metaphase kinetochores in PtK1 cells." Journal of Cell Science 96, no. 1 (May 1, 1990): 9–15. http://dx.doi.org/10.1242/jcs.96.1.9.

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Kinetochore microtubules are known to be differentially stable to a variety of microtubule depolymerization agents compared to the non-kinetochore polar microtubules, but the dynamics of microtubule attachment to the kinetochore is currently controversial. We have examined the stability of kinetochore microtubules in metaphase PtK1 spindles at 23 degrees C when microtubule assembly is abruptly blocked with the drug nocodazole. Metaphase cells were incubated in medium containing 34 microM nocodazole for various times before fixation and processing either for immunofluorescence light microscopy

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Infante, A. S., M. S. Stein, Y. Zhai, G. G. Borisy, and G. G. Gundersen. "Detyrosinated (Glu) microtubules are stabilized by an ATP-sensitive plus-end cap." Journal of Cell Science 113, no. 22 (November 15, 2000): 3907–19. http://dx.doi.org/10.1242/jcs.113.22.3907.

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Many cell types contain a subset of long-lived, ‘stable’ microtubules that differ from dynamic microtubules in that they are enriched in post-translationally detyrosinated tubulin (Glu-tubulin). Elevated Glu tubulin does not stabilize the microtubules and the mechanism for the stability of Glu microtubules is not known. We used detergent-extracted cell models to investigate the nature of Glu microtubule stability. In these cell models, Glu microtubules did not incorporate exogenously added tubulin subunits on their distal ends, while &gt;70% of the bulk microtubules did. Ca(2+)-generated f

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XuHan, X., and A. A. M. Van Lammeren. "Microtubular configurations during endosperm development in Phaseolus vulgaris." Canadian Journal of Botany 72, no. 10 (October 1, 1994): 1489–95. http://dx.doi.org/10.1139/b94-183.

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Microtubular cytoskeletons in nuclear, alveolar, and cellular endosperm of bean (Phaseolus vulgaris) were analyzed immunocytochemically and by electron microscopy to reveal their function during cellularization. Nuclear endosperm showed a fine network of microtubules between the wide-spaced nuclei observed towards the chalazal pole. Near the embryo, where nuclei were densely packed, bundles of microtubules radiated from nuclei. They were formed just before alveolus formation and functioned in spacing nuclei and in forming internuclear, phragmoplast-like structures that gave rise to nonmitosis-

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Vorobjev, I. A., T. M. Svitkina, and G. G. Borisy. "Cytoplasmic assembly of microtubules in cultured cells." Journal of Cell Science 110, no. 21 (November 1, 1997): 2635–45. http://dx.doi.org/10.1242/jcs.110.21.2635.

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The origin of non-centrosomal microtubules was investigated in a variety of animal cells in culture by means of time-lapse digital fluorescence microscopy. A previous study (Keating et al. (1997) Proc. Nat. Acad. Sci. USA 94, 5078–5083) demonstrated a pathway for formation of non-centrosomal microtubules by release from the centrosome. Here we show a parallel pathway not dependent upon the centrosome. Correlative immunostaining with anti-tubulin antibodies and electron microscopy established that apparent free microtubules observed in vivo were not growing ends of long stable microtubules. Fre

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Thèses sur le sujet "Microtubules"

Schaedel, Laura. "Les propriétés mécaniques des microtubules." Thesis, Université Grenoble Alpes (ComUE), 2016. http://www.theses.fr/2016GREAY010/document.

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Les microtubules-qui définissent la forme des axones, des cils et des flagelles, et qui servent de rails pour le transport intracellulaire-subissent de fortes contraintes exercées par les forces intracellulaires. La structure des microtubules et leur rigiditépeuvent en théorie être affectées par des contraintes physiques. Cependant, il reste à établir comment les microtubules tolèrent de telles forces et quelles sont les conséquences de ces forces sur la structure des microtubules. En utilisant un dispositif demicrofluidique, j’ai pu montrer que la rigidité des microtubules diminue progressive

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Barlukova, Ayuna. "Dynamic instability of microtubules and effect of microtubule targeting agents." Thesis, Aix-Marseille, 2017. http://www.theses.fr/2017AIXM0064.

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L'objectif de cette thèse est de proposer des modèles mathématiques permettant de décrire l'instabilité dynamique d'une population de microtubules (MTs) et l'effet de médicaments sur cette instabilité. L'instabilité dynamique des MTs joue un rôle extrêmement important dans les processus de la mitose et de la migration cellulaire et donc dans la progression tumorale. L'instabilité dynamique est un processus complexe qui implique différents états de la tubuline (polymérisée ou non-polymérisée, tubuline-GTP ou tubuline-GDP qui correspondent à deux états énergétiques différents des dimères) et qui

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Paez, Claudia. "Etude fonctionnelle de la protéine associée aux microtubules XMAP215/ch-TOG." Phd thesis, Université de Grenoble, 2011. http://tel.archives-ouvertes.fr/tel-00597065.

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Résumé Les protéines XMAP215/ch-TOG appartiennent à une famille de protéines associées aux microtubules (MAPs), bien conservée tout au long de l'évolution, la famille XMAP215/Dis1. Cette famille joue un rôle dans la régulation du cytosquelette des microtubules (MT), en particulier pendant la division cellulaire. Chez l'humain, ch-TOG est la protéine surexprimée dans les tumeurs du colon et du foie, une protéine qui provient de cellules blastiques et de plusieurs formes de cancer. Certaines protéines XMAP215/ch-TOG ont été retrouvées dans différentes localisations cellulaires, toujours reliées

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Rovini, Amandine. "De l'extrémité des microtubules aux mitochondries dans la neuroprotection mediee par l'olesoxime : vers une meilleure compréhension des mécanismes d'action des agents anti-microtubules." Thesis, Aix-Marseille, 2012. http://www.theses.fr/2012AIXM5512.

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Dans l’arsenal thérapeutique anticancéreux, les agents anti-microtubules (MTA) occupent une place essentielle dans le traitement de tumeurs solides et d’hémopathies malignes. Néanmoins, leur utilisation est limitée par l’induction d’une toxicité neurologique qui affecte la qualité de vie des patients et dont les mécanismes d’action demeurent peu compris. L’absence de solutions préventives ou curatives réellement efficaces, reflète la complexité des mécanismes d’action des MTA. Dans le cadre du projet « Mitotarget » (7ème PCRD) porté par le partenaire industriel Trophos, notre objectif était de

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Gaidar, Sergii, and Stefan Diez. "Dancing along microtubules." Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-182537.

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Peronne, Lauralie. "Caractérisation d'un nouveau composé pharmacologique qui potentialise la réponse des cellules au paclitaxel (Taxol®)." Thesis, Université Grenoble Alpes (ComUE), 2019. http://www.theses.fr/2019GREAV003.

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Les agents pharmacologiques ciblant la dynamique des microtubules (MTs) sont très utilisés en chimiothérapie des cancers agressifs. Le paclitaxel (PTX) est utilisé depuis des décennies et donne de bons résultats pour le traitement des tumeurs solides. Plusieurs inconvénients, notamment ses effets secondaires et la résistance de certains cancers limitent cependant l'efficacité de ce médicament. Dans le but d'identifier de nouveaux composés pharmacologiques qui sensibilisent les cellules au PTX, nous avons recherché, parmi une collection de 8000 molécules, celles capables de sensibiliser des cel

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Le, Grand Marion. "La protéine Akt, lien entre mitochondries et microtubules dans le mécanisme d'action des agents anti-microtubules ou quand les MTA s'invitent dans de nouvelles stratégies thérapeutiques." Thesis, Aix-Marseille, 2015. http://www.theses.fr/2015AIXM5017/document.

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De nos jours, les agents anti-microtubules (MTA) sont administrés dans de nombreuses pathologiques cancéreuses reflétant ainsi leur grande efficacité anti-tumorale. Cependant, leur utilisation se voit limitée pour deux raisons : (i) l’apparition d’effets indésirables et, (ii) l’émergence de cellules tumorales résistantes. Pour palier ces problèmes, les MTA font l’objet de nombreux travaux de recherche faisant ainsi de ces composés des médicaments toujours dans l’ère du temps. L’objectif principal des travaux présentés dans ce manuscrit repose sur l’étude du mécanisme d’action des MTA afin d’op

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Gallaud, Emmanuel. "Caractérisation du rôle d'Ensconsine / MAP7 dans la dynamique des microtubules et des centrosomes." Thesis, Rennes 1, 2014. http://www.theses.fr/2014REN1S004/document.

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La mitose est une étape essentielle du cycle cellulaire à l’issue de laquelle le génome répliqué de la cellule mère est ségrégé de façon équitable entre les deux cellules filles. Pour cela, la cellule assemble une structure hautement dynamique et composée de microtubules, appelée le fuseau mitotique. En plus d’assurer la bonne ségrégation des chromosomes, le fuseau mitotique détermine l’axe de division, un phénomène particulièrement important pour la division asymétrique où des déterminants d’identité cellulaire doivent être distribués de façon inéquitable entre les deux cellules filles. L’ass

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A, S. Jijumon. "Systematic characterization of a large number of Microtubule-Associated Proteins using purification-free TIRF-reconstitution assays Purification of tubulin with controlled post-translational modifications by polymerization–depolymerization cycles Microtubule-Associated Proteins: Structuring the Cytoskeleton Purification of custom modified tubulin from cell lines and mouse brains by polymerization-depolymerization cycles." Thesis, université Paris-Saclay, 2021. http://www.theses.fr/2021UPASL007.

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Le cytosquelette des microtubules (MTs) est constitué de filaments dynamiques impliqués dans une multitude de fonctions telles que la division cellulaire, le maintien de forme des cellules, les battements ciliaires ou encore la différenciation neuronale. Une régulation stricte des fonctions des MTs est donc d'une grande importance pour l'homéostasie cellulaire, et toute perturbation pourrait potentiellement conduire à des maladies comme le cancer, les ciliopathies ou la neurodégénérescence. Dans un contexte cellulaire, les propriétés des MTs peuvent être contrôlées par leurs interactions avec

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Nouar, Roqiya. "Caractérisation de l'intéraction de la stathmine avec les microtubules : une analyse par imagerie FRET dans la cellule." Thesis, Aix-Marseille, 2013. http://www.theses.fr/2013AIXM5505.

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Livres sur le sujet "Microtubules"

S, Hyams Jeremy, and Lloyd Clive W, eds. Microtubules. New York: Wiley-Liss, 1994.

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International Symposium on Microtubules and Microtubule Inhibitors (3rd 1985 Beerse, Belgium). Microtubules and microtubule inhibitors, 1985: Proceedings of the 3rd International Symposium on Microtubules and Microtubule Inhibitors, Beerse, Belgium, 3-6 September, 1985. Edited by Brabander M. de, Mey J. de, Janssen Research Foundation, and Belgian Society for Cell Biology. Amsterdam: Elsevier Science, 1985.

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Nick, Peter, ed. Plant Microtubules. Berlin, Heidelberg: Springer Berlin Heidelberg, 2008. http://dx.doi.org/10.1007/978-3-540-77178-4.

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Nick, Peter, ed. Plant Microtubules. Berlin, Heidelberg: Springer Berlin Heidelberg, 2000. http://dx.doi.org/10.1007/978-3-662-22300-0.

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International Symposium on Microtubules and Microtubule Inhibitors (3rd 1985 Beerse). Microtubules and microtubule inhibitors, 1985: Proceedings on the 3rd International Symposium on Microtubules and Microtubule Inhibitors. Beerse, Belgium, 3-6 September, 1985. Edited by Brabander M. de, Mey J. de, Janssen Research Foundation, and Belgian Society for Cell Biology. Oxford: Elsevier, 1985.

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service), ScienceDirect (Online, ed. Microtubules: In vivo. Amsterdam: Elsevier/Academic Press, 2010.

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service), ScienceDirect (Online, ed. Microtubules, in vitro. Amsterdam: Elsevier/Academic Press, 2010.

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Lutz, Regina Anna. Regulation of Polarity by Microtubules. [New York, N.Y.?]: [publisher not identified], 2015.

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Sutton, Michael Mark. The Influence of Microtubules and Microtubule-Based Structures on Osteoclast and CD4+ T Cell Function. [New York, N.Y.?]: [publisher not identified], 2022.

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Wróbel, Zygmunt. Automatyczne metody analizy orientacji mikrotubul. Katowice: Wydawn. Uniwersytetu Śląskiego, 2007.

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Chapitres de livres sur le sujet "Microtubules"

Iwanski, Malina K., Eugene A. Katrukha, and Lukas C. Kapitein. "Lattice Light-Sheet Motor-PAINT: A Method to Map the Orientations of Microtubules in Complex Three-Dimensional Arrays." In Single Molecule Analysis, 151–74. New York, NY: Springer US, 2023. http://dx.doi.org/10.1007/978-1-0716-3377-9_8.

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AbstractMicrotubules play an essential role in many cellular functions, in part by serving as tracks for intracellular transport by kinesin and dynein. The ability of microtubules to fulfill this role fundamentally depends on the fact that they are polar, with motors moving along them toward either their plus or minus end. Given that the microtubule cytoskeleton adopts a variety of specialized architectures in different cell types, it is important to map precisely how microtubules are oriented and organized in these cells. To this end, motor-PAINT has been developed, but in its current implementation, it relies on total internal reflection fluorescence (TIRF) microscopy and is thus restricted to imaging microtubules in a thin section of the cell immediately adjacent to the coverslip. Here, we report a variant of motor-PAINT that uses lattice light-sheet microscopy to overcome this, allowing for the mapping of microtubule organization and orientation in three-dimensional samples. We describe the necessary steps to purify, label, use, and image kinesin motors for motor-PAINT and outline the analysis pipeline used to visualize the resulting data. The method described here can be used in the future to study the microtubule cytoskeleton in (thick) polarized cells such as intestinal epithelial cells.

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Wade, Richard H. "Microtubules." In Methods in Molecular Medicine™, 1–16. Totowa, NJ: Humana Press, 2007. http://dx.doi.org/10.1007/978-1-59745-442-1_1.

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Wasteneys, Geoffrey O., and Bettina Lechner. "Microtubules." In Cellular Domains, 229–43. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2011. http://dx.doi.org/10.1002/9781118015759.ch14.

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Sabnis, D. D. "Microtubules." In Cell Components, 375–94. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-82587-3_18.

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Visintin, Rosella. "Microtubules." In Encyclopedia of Systems Biology, 1358. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-9863-7_1432.

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Schliwa, Manfred. "Microtubules." In The Cytoskeleton, 47–82. Vienna: Springer Vienna, 1986. http://dx.doi.org/10.1007/978-3-7091-7667-2_3.

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Gooch, Jan W. "Microtubules." In Encyclopedic Dictionary of Polymers, 907. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_14230.

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Dráber, Pavel, and Eduarda Dráberová. "Microtubules." In Cytoskeleton and Human Disease, 29–53. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-61779-788-0_2.

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Gupta, G. S. "Microtubules." In Proteomics of Spermatogenesis, 167–90. Boston, MA: Springer US, 2005. http://dx.doi.org/10.1007/0-387-27655-6_8.

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Heinlein, Manfred. "Microtubules and Viral Movement." In Plant Microtubules, 141–73. Berlin, Heidelberg: Springer Berlin Heidelberg, 2008. http://dx.doi.org/10.1007/7089_2007_147.

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Actes de conférences sur le sujet "Microtubules"

Sinha, S., and D. D. Wagner. "INTACT MICROTUBULES ARE NECESSARY FOR COMPLETE PROCESSING, STORAGE AND REGULATED SECRETION OF VON WILLEBRAND FACTOR BY ENDOTHELIAL CELLS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642914.

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The importance of intact microtubules in the processing, storage and regulated secretion of von Willebrand factor (vWf) from Weibel-Palade bodies in endothelial cells was investigated. Human umbilical vein endothelial cells treated for one hour with colchicine (10-6M) or nocodozole (10-6M) lost their organized microtubular network. Stimulation of these cells with secretagogues (A23187, thrombin) produced only 30% release of vWf in comparison to control cells containing intact microtubules. The nocodazole treatment was reversible. One hour incubation in the absence of the drug was sufficient fo

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Ghavanoo, E., F. Daneshmand, and M. Amabili. "Two-Dimensional Shell Vibration of Microtubule in Living Cell." In ASME 2010 3rd Joint US-European Fluids Engineering Summer Meeting collocated with 8th International Conference on Nanochannels, Microchannels, and Minichannels. ASMEDC, 2010. http://dx.doi.org/10.1115/fedsm-icnmm2010-30636.

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The mechanical behavior of a eukaryotic cell is mainly determined by its cytoskeleton. Microtubules immersed in cytosol are a central part of the cytoskeleton. Cytosol is the viscous fluid in living cells. The microtubules permanently oscillate in the cytosol. In this study, two-dimensional vibration of a single microtubule in living cell is investigated. The Donnell’s shell theory equations for orthotropic materials is used to model the microtubule whereas the motion of the cytosol is modeled as Stokes flow characterized by a small Reynolds number with no-slip condition at microtubule-cytosol

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Allen, Kathleen B., and Bradley E. Layton. "Mechanical Neural Growth Models." In ASME 2005 International Mechanical Engineering Congress and Exposition. ASMEDC, 2005. http://dx.doi.org/10.1115/imece2005-79445.

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Critical to being able to control the growth patterns of cell-based sensors is being able to understand how the cytoskeleton of the cell maintains its structure and integrity both under mechanical load and in a load-free environment. Our approach to a better understanding of cell growth is to use a computer simulation that incorporates the primary structures, microtubules, necessary for growth along with their observed behaviors and experimentally determined mechanical properties. Microtubules are the main compressive structural support elements for the axon of a neuron and are created via pol

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Kuznetsov, A. V., A. A. Avramenko, and D. G. Blinov. "Simulation of Traffic Jam Formation in Fast Axonal Transport." In ASME 2009 Heat Transfer Summer Conference collocated with the InterPACK09 and 3rd Energy Sustainability Conferences. ASMEDC, 2009. http://dx.doi.org/10.1115/ht2009-88345.

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Many neurodegenerative diseases, such as Alzheimer’s disease, are linked to swellings occurring in long arms of neurons. Many scientists believe that these swellings result from traffic jams caused by the failure of intracellular machinery responsible for fast axonal transport; such traffic jam can plug an axon and prevent the sufficient amount of organelles to be delivered toward the synapse of the axon. Mechanistic explanation of the formation of traffic jams in axons induced by overexpression of tau protein is based on the hypothesis that the traffic jam is caused not by the failure of mole

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Mehrbod, Mehrdad, and Mohammad R. K. Mofrad. "On the Mechanics of Microtubule Filaments." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53896.

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Quantitative understanding of cell mechanics has challenged biological scientists during the past couple of decades. one of the promising attempts towards mechanical modeling of the cytoskeleton has been the “tensegrity” cytoskeletal model, which simplifies the complex network of cytoskeletal filaments as a structure merely composed of compression-bearing elements (hinge-ended struts) and tensile members (cables). This discrete model can interestingly explain many experimental observations in cell mechanics. However, evidence suggests that the simplicity of this model may undermine the accurac

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Aprodu, Iuliana, Alfonso Gautieri, Franco M. Montevecchi, Alberto Redaelli, and Monica Soncini. "What Molecular Dynamics Simulations Can Tell Us About Mechanical Properties of Kinesin and Its Interaction With Tubulin." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176316.

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Kinesin is a processive molecular motor found in various cells including neurons, that transports membrane-bound vesicles and organelles along the microtubule. Kinesin typically consists of three distinct domains: two large globular heads that attach to the microtubule, a central coiled region, and a light-chain that attaches to the cellular cargo. The metabolic energy that drives kinesins is provided in the form of ATP. The energy released by ATP hydrolysis is converted into direct movement after kinesin binds strongly to the microtubule. Two mechanisms were proposed to explain the movement o

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Tan, X. Gary, Andrzej J. Przekwas, and Raj K. Gupta. "Macro-Micro Biomechanics Finite Element Modeling of Brain Injury Under Concussive Loadings." In ASME 2016 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/imece2016-66218.

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Traumatic brain injury (TBI) occurs in many blunt, ballistic and blast impact events. During trauma axons in the white matter are especially vulnerable to injury due to the rapid mechanical loading of brain. The axonal pathology leads to cytoskeletal failure and disconnection. The microtubules are one of major structural components of the cytoskeleton filamentous network. By bridging the macroscopic forces acting on the whole brain with the cellular and subcellular failure, the macro-micro computational models in both time and space can help us better understand the complex biophysics and eluc

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Oswald, Elizabeth S., Pen-hsiu Grace Chao, J. Chloe Bulinski, Gerard A. Ateshian, and Clark T. Hung. "The Role of Microtubule Organization in Chondrocyte Response to Osmotic Loading." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176634.

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The cytoskeleton, including actin filaments and microtubules, provides chondrocytes with structure, cytoplasmic organization, and intracellular transport. The cytoskeleton is known to be involved in cellular responses to physiologic mechanical and osmotic loading signals, including morphological changes and mechanostransduction [1, 2]. Here, we examine microtubule (MT) involvement in volume response of chondrocytes to osmotic loading, as well as organization of stable MT with hypoosmotic loading. We also explore the hypothesis that chondrocytes from different zones of cartilage possess cytoske

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Xu, Gang, Kate S. Wilson, Ruth J. Okamoto, Jin-Yu Shao, Susan K. Dutcher, and Philip V. Bayly. "The Apparent Flexural Rigidity of the Flagellar Axoneme Depends on Resistance to Inter-Doublet Sliding." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80220.

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Cilia are thin subcellular organelles that bend actively to propel fluid. The ciliary cytoskeleton (the axoneme) consists of nine outer microtubule doublets surrounding a central pair of singlet microtubules. Large bending deformations of the axoneme involve relative sliding of the outer doublets, driven by the motor protein dynein. Ciliary structure and function have been studied extensively, but details of the mechanics and coordination of the axoneme remain unclear. In particular, dynein activity must be switched on and off at specific times and locations to produce an oscillatory, propulsi

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Huang, Y., M. Uppalapati, W. Hancock, and T. Jackson. "Movement Control of Confined Microtubules." In 2006 64th Device Research Conference. IEEE, 2006. http://dx.doi.org/10.1109/drc.2006.305158.

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Rapports d'organisations sur le sujet "Microtubules"

Frisch, Steven M. Are Microtubules Involved in Anoikis. Fort Belvoir, VA: Defense Technical Information Center, August 2001. http://dx.doi.org/10.21236/ada397720.

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Brumlik, Charles J., and Charles R. Martin. Template Synthesis of Metal Microtubules. Fort Belvoir, VA: Defense Technical Information Center, March 1991. http://dx.doi.org/10.21236/ada232827.

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Margerum, J. D. Applications Research Studies of Microtubules. Fort Belvoir, VA: Defense Technical Information Center, August 1990. http://dx.doi.org/10.21236/ada225694.

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Fisher, D. D., and R. J. Cyr. Calmodulin immunolocalization to cortical microtubules is calcium independent. Office of Scientific and Technical Information (OSTI), December 1992. http://dx.doi.org/10.2172/10156994.

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Fisher, D. D., and R. J. Cyr. Calmodulin immunolocalization to cortical microtubules is calcium independent. Office of Scientific and Technical Information (OSTI), January 1992. http://dx.doi.org/10.2172/6434308.

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Cyr, R. Role of Ca[sup ++]/calmodulin in the regulation of microtubules in higher plants. Office of Scientific and Technical Information (OSTI), January 1991. http://dx.doi.org/10.2172/7137008.

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Cyr, R. Role of Ca[sup ++]/calmodulin in the regulation of microtubules in higher plants. Office of Scientific and Technical Information (OSTI), January 1992. http://dx.doi.org/10.2172/6528240.

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Cyr, R. Role of Ca{sup ++}/calmodulin in the regulation of microtubules in higher plants. Progress report, FY91. Office of Scientific and Technical Information (OSTI), December 1991. http://dx.doi.org/10.2172/10109506.

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Cyr, R. Role of Ca{sup ++}/calmodulin in the regulation of microtubules in higher plants. Progress report, FY 1992. Office of Scientific and Technical Information (OSTI), December 1992. http://dx.doi.org/10.2172/10159592.

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Bulinski, Chloe J. Novel Microtubule-Stabilizing Reagents. Fort Belvoir, VA: Defense Technical Information Center, September 2005. http://dx.doi.org/10.21236/ada446411.

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