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Littérature scientifique sur le sujet « MKC »

Auteur : Grafiati

Publié le 4 juin 2021

Mis à jour le 7 février 2022

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Articles de revues sur le sujet "MKC"

Rusdiaman, Rusdiaman, et Sisilia Teresia Dewi. « UJI EFEKTIVITAS INFUSA DAUN SAWO (Manilkara zapota L.) TERHADAP PERTUMBUHAN Salmonella thypiUJI EFEKTIVITAS INFUSA DAUN SAWO (Manilkara zapota L.) TERHADAP PERTUMBUHAN Salmonella thypi ». Media Farmasi 15, n^o 1 (24 mai 2019) : 7. http://dx.doi.org/10.32382/mf.v15i1.859.

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Uji Efektivitas Infus Daun Sawo (Manilkara zapota L.) Terhadap Pertumbuhan Salmonella thypi. Telah dilakukan penelitian tentang Uji Efektivitas Infus Daun Sawo (Manilkara zapota L.) Terhadap Pertumbuhan Salmonella thypi yang bertujuan untuk menentukan nilai MIC (Minimum Inhibitory Concentration) dan MKC (Minimum Killing Concentration) dari infus Daun Sawo terhadap Salmonella thypi. Ekstraksi dilakukan dengan menggunakan metode infus untuk menyari zat aktif dan dibuat dengan konsentrasi 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45% dan 50%b/v. Penentuan MIC dilakukan dengan metode dilusi cair setelah 1×24 jam diinkubasi sedangkan penentuan MKC dilakukan setelah inkubasi selama 2×24 jam. Hasil penelitian menunjukkan bahwa nilai MIC dari infus Daun Sawo terhadap Salmonella thypi adalah konsentrasi 30% dan nilai MKC dari infus Daun Sawo terhadap Salmonella thypi adalah konsentrasi 50%. Kata kunci : Daun Sawo, Salmonella thypi, Dilusi Cair, MIC dan MKC

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Ratnah, Siti, et Alfrida Monica Salasa. « EFEKTIFITAS EKSTRAK BIJI BUAH KELENGKENG (Euphoria longan Stend) TERHADAP PERTUMBUHAN Staphylococcus aureus dan Propionibacterium acne ». Media Farmasi 16, n^o 1 (11 mai 2020) : 105. http://dx.doi.org/10.32382/mf.v16i1.1411.

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Biji Buah Kelengkeng merupakan limbah, tetapi mengandung senyawa fitokimia yang dapat dimanfaatkan baik sebagai antibakteri.. Tujuan penelitian ini adalah untuk menentukan konsentrasi Minimum Inhibitory Concentration (MIC) dan Minimum Killing Concentration (MKC) dari ekstrak biji buah kelengkeng terhadap pertumbuhan Staphylococcus aureus dan Propionibacterium acne. Bahan uji dibuat simplisia kering, diekstraksi dengan etanol 96 % dengan metode sokhletasi, diuji nilai MIC dan MKC dengan metode dilusi cair. Hasil yang diperoleh menunjukkan bahwa Minimum Inhibitory Concentration ekstrak biji buah kelengkeng terhadap pertumbuhan Staphylococcus aureus dan Propionibacterium acne adalah 2 %b/v dan Minimum Killing Concentration untuk kedua bakteri tersebut adalah 3 %b/v.Kata Kunci : Ekstraksi, MIC, MKC, Staphylococcus aureus dan Propionibacterium acne

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&NA;. « MKC 242 ». Drugs in R & ; D 2, n^o 1 (février 1999) : 53–54. http://dx.doi.org/10.2165/00126839-199902010-00016.

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Furman, P. A., et C. Moxham. « MKC-442 ». Drugs of the Future 23, n^o 7 (1998) : 718. http://dx.doi.org/10.1358/dof.1998.023.07.466749.

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Revel, L., X. Rabasseda et J. Castañer. « MKC-733 ». Drugs of the Future 24, n^o 9 (1999) : 966. http://dx.doi.org/10.1358/dof.1999.024.09.489134.

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Dulsat, C., R. Castañer et J. Bolós. « MKC-1 ». Drugs of the Future 34, n^o 4 (2009) : 270. http://dx.doi.org/10.1358/dof.2009.034.04.1365146.

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Tracy, M., J. Prous et J. Castañer. « MKC-242 ». Drugs of the Future 22, n^o 3 (1997) : 225. http://dx.doi.org/10.1358/dof.1997.022.03.400249.

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Salasa, Alfrida Monica, St Ratnah et Ismail Ibrahim. « PENENTUAN NILAI MIC (MINIMUM INHIBITORY CONCENTRATION) DAN MKC (MINIMUM KILLING CONCENTRATION) EKSTRAK DAUN KECOMBRANG (Etlingera elatior) TERHADAP Candida albicans PENYEBAB KEPUTIHAN ». Media Farmasi 15, n^o 1 (24 mai 2019) : 30. http://dx.doi.org/10.32382/mf.v15i1.781.

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Tanaman Kecombrang memiliki kandungan kimia seperti alkaloid, flavonoid, polifenol,steroid, saponin, dan minyak atsiri. Kandungan senyawa fitokimia pada tanaman diketahui mempunyai peranan yang sangat penting bagi kesehatan termasuk fungsinya dalam pencegahan terhadap penyakit. Tujuan dari penelitian ini adalah untuk menentukan nilai MIC (Minimum Inhibitory Concentration) dan MKC (Minimum Killing Concentration) dari Ekstrak Daun Kecombrang (Etlingera elatior) terhadap pertumbuhan Candida albicans dengan metode dilusi cair. Penelitian ini merupakan eksperimen murni menggunakan ekstrak daun kecombrang lalu ditentukan nilai MIC dan MKC dengan menggunakan metode dilusi cair. Konsentrasi yang digunakan adalah 1,25 %; 2,5%; 3,75%; 5%; 6,25%; 7,5%; 8,75%; 10%; 12,5%; 15%; 17,5%; 20%; 22,5%; 25% b/v. Hasil penelitian menunjukkan bahwa nilai MIC (Minimum Inhibitory Concentration) ekstrak Daun Kecombrang terdapat pada konsentrasi 6,25% b/v dan nilai MKC (Minimum Killing Concentration) terdapat pada konsentrasi 8,75% b/v. Hal ini menunjukkan bahwa ekstrak Daun Kecombrang (Etlingera elatior) efektif untuk menghambat dan membunuh jamur Candida albicans.

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Denny, Trisha A., Xiaoru Chen, Cassandra L. Waters, Patricia A. Burke, Graham C. Fletcher, John Xu, Carolyn F. Sidor, Mark D. Minden, Theresa M. LaVallee et Mark R. Bray. « MKC-1 Is a Novel Agent That Induces Cell Cycle Arrest and Disrupts Multiple Survival Pathways in Hematologic Cancers. » Blood 108, n^o 11 (16 novembre 2006) : 4390. http://dx.doi.org/10.1182/blood.v108.11.4390.4390.

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Abstract MKC-1 is a novel, orally active cell cycle inhibitor with in vitro and in vivo activity against a wide range of human solid tumor cell lines, including multi-drug resistant cell lines. MKC-1 has been tested in over 270 patients to date and is currently in Phase II clinical trials. The strong pre-clinical activity of MKC-1 towards solid tumor lines and signs of efficacy in the initial clinical evaluation with lack of neuropathy and cardiotoxicity suggests that MKC-1 may also be of clinical benefit in the treatment of hematopoietic cancers. The antiproliferative activity of MKC-1 was examined against a panel of hematopoietic cell lines including HL-60, U937, MV4;11, THP-1, Jurkat, and OCI-AML 1–5. MKC-1 showed potent and dose-dependent activity towards these cell lines, with IC50 values in the range of 20 – 400 nM. MKC-1 also inhibited in vitro growth of primary cells derived from AML and CML patients. Additionally, MKC-1 showed enhanced activity with Ara-C in combination studies in vitro when added either simultaneously or sequentially using the cell line OCI-AML 4. Binding studies have shown that MKC-1 binds to the colchicine binding site of tubulin and to members of the importin beta family of proteins. Consistent with these results, cell cycle arrest in the G2/M phase of the cell cycle followed by apoptosis was observed in cell lines and patient samples treated with MKC-1. Immunofluorescence analysis of cells treated with MKC-1 revealed that the drug induced a disruption of the microtubule network and the formation of aberrant mitotic spindles. Furthermore, MKC-1 was also shown to induce a dose-dependent reduction in the levels of both phospho-Akt and phospho-p70S6K kinases through Western blot analysis of treated THP-1 cells. In conclusion, our results indicate MKC-1 arrests the cell cycle and disrupts multiple survival pathways to induce apoptosis in hematopoietic cell lines and patient samples. These results suggest that MKC-1 may have clinical potential in the treatment of leukemia either alone or in combination with other agents. Phase I trials in hematological cancers are currently being explored.

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Löser, Christoph, Rainer Rompel, Matthias Möhrle, Hans-Martin Häfner, Christian Kunte, Jessica Hassel, Ulrich Hohenleutner et al. « Mikroskopisch kontrollierte Chirurgie (MKC) ». JDDG : Journal der Deutschen Dermatologischen Gesellschaft 8, n^o 11 (22 octobre 2010) : 920–25. http://dx.doi.org/10.1111/j.1610-0387.2010.07314_supp.x.

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Thèses sur le sujet "MKC"

NUNES, Roberto da Silva. « Números primos e a constituição do MMC e MDC ». Universidade Federal do Pará, 2017. http://repositorio.ufpa.br/jspui/handle/2011/10514.

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Nesta pesquisa temos como objetivo elaborar uma Sequência Didática baseada em Rickenmann e sempre recorrendo a conhecimentos prévios que favoreçam a compreensão das noções de Mínimo Múltiplo Comum (MMC) e do Máximo Divisor Comum (MDC) inspirados no Crivo de Eratóstenes. Para alcançar o objetivo, assumiremos como suporte teórico a Teoria das Situações Didáticas fazendo uso de aspectos da Engenharia Didática como metodologia de pesquisa. Para elaboração da Sequência realizamos um estudo histórico com viés epistemológico abarcando as definições matemáticas à luz da Teoria dos Números, bem como a extensão dos mesmos, o conhecimento das origens e como os objetos vêm sendo pesquisados e apresentados em livros didáticos.
In this research we aim to elaborate a Didactic Sequence based on Rickenmann and always resorting to previous knowledge that favors the understanding of the notions of Minimum Common Multiple (CMM) and Maximum Common Divisor (MDC) inspired by the Sieve of Eratosthenes. In order to reach the objective, we will assume as theoretical support the Theory of Didactic Situations making use of Didactic Engineering aspects as research methodology. For the elaboration of the Sequence we carry out a historical study with epistemological bias covering the mathematical definitions in the light of Number Theory, as well as the extension of the same ones, the knowledge of the origins and how the objects have been researched and presented in didactic books.
SEDUC/PA - Secretaria de Estado de Educação
SEMEC/PA - Secretaria Municipal de Educação

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Corcoran, Kathleen M. « EVIDENCE FOR ADAPTER-MEDIATED SUBSTRATE SELECTION IN ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATION ». Diss., The University of Arizona, 2009. http://hdl.handle.net/10150/195549.

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Viruses have evolved a multitude of mechanisms, which allow immune evasion in both initial and persistent infection. Understanding the intricacies of these pathways is essential to our future ability to combat primary and reactive viral infections. The murine gamma-2 herpesvirus 68 (γHV68) encodes a protein mK3, which targets Major Histocompatibility Complex (MHC) class I heavy chains for ubiquitin-dependent proteasome degradation. MK3 is able to target and ubiquitinate MHC class I by binding to Endoplasmic Reticulum (ER) resident proteins tapasin, Transporter associated with antigen processing (TAP) 1 and TAP2 that are subunits in the complex known as the peptide-loading complex (PLC). The aforementioned characteristics of mK3 make this novel protein an excellent vehicle to study MHC class I assembly, immune evasion, and ER associated degradation (ERAD). Deepening our understanding of class I assembly and viral immune evasion will impact both the fields of immunology and virology. The homology between γHV68 and many of the human γ-herpesviruses makes this an indispensable model to clarify mechanisms that can then be applied to a broader spectrum of viruses. ERAD, an emerging field of study, is known to play a key role in numerous cellular housekeeping pathways as well as a number of disease states. Illuminating the mechanisms implicated in the mK3-mediated ubiquitination of MHC class I, specifically requirements for substrate recognition and degradation, will yield an increased understanding of cellular pathways involved in ERAD. The studies in this dissertation aim to expand our understanding of the relationship between mK3 and adapter proteins TAP/tapasin as well as mK3 and mK3-targeted substrates. The results show that TAP/tapasin act as adapter proteins by recruiting substrates for mK3. Further, mK3 ubiquitinates TAP/tapasin-associated substrates as long as the substrates have a tail greater than 6aa in length and the tail possesses an ubiquitin acceptor residue (lysine, serine or threonine). These studies also confirm that location of a protein within the PLC will determine the substrate’s susceptibility to mK3-mediated degradation. In the field of ubiquitin ligases and ERAD, these studies lend support to the concept of adapter mediated substrate recruitment.

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Vogel, Teresa Maria [Verfasser]. « Die Expression von MHC Klasse I verwandten Genen (MIC) bei Psoriasis vulgaris / Teresa Maria Vogel ». Kiel : Universitätsbibliothek Kiel, 2018. http://d-nb.info/1156264642/34.

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MAURICIO, E. M. « Uma Proposta de Sequência Didática para o Ensino de MDC e MMC na Educação Básica ». Universidade Federal do Espírito Santo, 2014. http://repositorio.ufes.br/handle/10/4825.

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Este Trabalho consiste em uma sequência didática voltada aos professores da educação básica, principalmente, da rede pública estadual. Essa sequência trata em especial do cálculo do MDC por meio da divisão euclidiana. Aproveitamos o ensejo para discorrer um pouco sobre divisibilidade, MMC e primos. A proposta em questão é formada por 4 capítulos. Em cada em deles há uma lista de exercícios. Ao final do capítulo 4, acrescentamos uma sequência de exercícios complementares.

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De, Juan Sanjuan Cristina. « Identification of major histocompatibility complex (MHC) class I chain-related (MIC) and HFE genes in cattle ». Thesis, University of Bristol, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.434741.

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Oble, Frédéric. « Intérêts et limites de l'analyse structurelle et de la méthode Delphi appliquées à l'étude de l'évolution des marchés alimentaires ». Vandoeuvre-les-Nancy, INPL, 1992. http://docnum.univ-lorraine.fr/public/INPL_T_1992_OBLE_F.pdf.

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Les marchés alimentaires sont en constante évolution, et les entreprises agro-alimentaires ont donc besoin d'outils performants pour anticiper ces évolutions et développer des stratégies adaptées. Les méthodes de prospective se distinguent par leur philosophie vis-à-vis du futur des méthodes de prévision. A une conception d'un futur unique, prévisible par extrapolation des tendances passées, la prospective oppose une multiplicité de futurs possibles et explique que la réalisation d'un de ces futurs dépend de notre action présente. Notre travail de recherche présente d'un point de vue méthodologique et critique trois outils utilisés en prospective, sur la base de deux cas d'étude pris dans l'agro-alimentaire. Deux méthodes d'analyse structurelle (MIC-MAC et Louis DIRN) ont été appliquées à l'étude des facteurs déterminants pour l'évolution du marché des boissons alcoolisées. La méthode Delphi d'enquête par consultation d'experts a été utilisée pour conduire une étude prospective des produits alimentaires de l'axe nutrition-santé à partir de l'exemple des produits laitiers sans cholestérol. Les intérêts et limites de chacune des méthodes utilisées sont examinés et discutés et en conclusion, nous proposons une combinaison possible de ces trois outils dans le cadre de la méthode des scenarios

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Uppström, Alexandra. « Effekten av substansen propylenglykol på stafylokocker från human hud ». Thesis, Malmö universitet, Institutionen för biomedicinsk vetenskap (BMV), 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-43672.

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Hudens normalflora består av lågpatogena bakterier där stafylokockerna är de vanligaste förekommande bakterierna. Studier visar att antimikrobiella medel kan förändra hudbakteriepopulationer och att dessa förändringar kan leda till kritiska konsekvenser för hudens försvar. Propylenglykol är en substans som klassas som antimikrobiell och bakteriedödande. Propylenglykol har ett brett användningsområde och används ofta som hjälpmedel i en mängd olika läkemedel. Den finns bland annat i kosmetika såsom hudprodukter där den fungerar som fuktbindande och som konserveringsmedel. Vanliga koncentrationer av propylenglykol som fuktighetsbevarande ämne i topikaler är cirka 15 % och i kosmetika finns propylenglykol i koncentrationerna <0,1 % - >50 %. Det saknas i nuläget forskning om propylenglykols effekt på hudens bakterieflora. Syftet med studien var att med olika koncentrationer av propylenglykol bestämma MIC (minsta hämmande koncentration) och MBC (minsta baktericida koncentration) på vanliga stafylokocker (S. epidermidis, S. aureus, S. hominis och S. capitis) som ingår i hudens normalflora. För att bestämma MIC och MBC användes buljongspädningsmetoden där propylenglykol späddes ut i olika koncentrationer med buljong i en mikrotiterplatta. Sedan tillsattes valda testbakterier och OD600 mättes i 24 timmar. Resultatet visade att MIC och MBC för propylenglykol var 12,5 % respektive 25 % på vanliga stafylokocker som finns på huden. Vid koncentrationer av propylenglykol på 12,5 % hämmades synlig bakterietillväxt av S. epidermidis, S. aureus, S. hominis och S. capitis och vid 25 % uppstod en baktericid effekt på bakterierna. Mer forskning behövs dock för att få reda på hur hudens bakterier påverkas av propylenglykol och konsekvenserna av det.
The normal flora of the human skin is consisting of low pathogen bacteria, where the staphylococci are the most common bacteria. Studies show that antimicrobial substances can alter populations of skin bacteria and that these alterations can lead to critical consequences for the resistance of the skin. Propylene glycol is a substance that is classified as antimicrobial and bactericidal and the substance has a wide area of use and is frequently used as a supportive substance in various pharmaceuticals. Propylene glycol can be found in cosmetics and skincare products where it functions as moisture-binding and preservative. Normal concentrations of propylene glycol as moisture-binding substance in topicals is approximately 15 % and in cosmetics the concentration of propylene glycol is <0,1 % - >50 %. As of today, there are few scientific studies regarding the effects of propylene glycol to the bacterial flora of the human skin. The purpose of this study was to determine MIC (minimum inhibitory concentration) and MBC (minimum bactericidal concentration) for normal staphylococci (S. epidermidis, S. aureus, S. hominis och S. capitis) included in the normal flora of the skin using various concentrations of propylene glycol. To be able to determine MIC and MBC the broth dilution method was used, where propylene glycol was diluted in various concentrations with broth in a microtiter plate. Hereafter, selected test bacteria were added and OD600 was measured during 24 hours. The results implicated that MIC and MBC for propylene glycol were 12,5 % and 25 % for common staphylococci located on the skin. At concentrations of propylene glycol of 12,5 %, visible bacterial growth of S. epidermidis, S. aureus, S. hominis and S. capitis was inhibited and at 25 % a bactericidal effect occurred on the bacteria. It shall be noted that further research is needed to find out how the skin's bacteria are affected by propylene glycol and its consequences.

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Kulkarni, Santosh B. Umphress David A. Agrawal Prathima. « Synergy MAC a cooperative MAC protocol / ». Auburn, Ala, 2009. http://hdl.handle.net/10415/1609.

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Chitadze, Guranda [Verfasser]. « Expression and shedding of MHC class I-related chain (MIC) A and B molecules in human carcinoma cell lines / Guranda Chitadze ». Kiel : Universitätsbibliothek Kiel, 2014. http://d-nb.info/1046312669/34.

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Graalmann, Lorenz [Verfasser], Johannes [Gutachter] Bode et Julia [Gutachter] Reifenberger. « Regulation der LPS-induzierten STAT3-Aktivierung durch MK2 und MK3 in Makrophagen und Fibroblasten / Lorenz Graalmann ; Gutachter : Johannes Bode, Julia Reifenberger ». Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2018. http://d-nb.info/1162697652/34.

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Livres sur le sujet "MKC"

Brewaeys, Philippe. Ecoovie : Le Mic-Mac des services secrets. Bruxelles : EPO, 1990.

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Muet, Pierre-Alain. MIC MAC : La macroéconomie par la micro informatique. Paris : Economica, 1987.

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Mac Mic Iascaire Buí Luimnigh : Seanscéal as Tír Amhalghaidh. Indreabhán, Conamara : Cló Iar-Chonnachta, 1992.

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Chesneau, Roger. Harrier GR 5 & GR 7 : British Aerospace Harrier GR Mk5/Mk7. Ongar, Essex : Linewrights Ltd., 1990.

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MacLean, John. Mac. London : Pan, 1988.

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Cherel, Jean-Se bastien. Mac. Paris : Micro Application, 2009.

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Mac. Ḍairah Ismāʻīl K̲h̲ān : Q Pablīkeshanz, 2008.

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Spivey, Dwight. Mac. 2^e éd. New York : McGraw-Hill, 2010.

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Mathieu, Sapin, dir. MKM. Madrid : Dibbuks, 2013.

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Ithel, Rhian. Mac. Llandysul : Gomer, 1995.

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Chapitres de livres sur le sujet "MKC"

Zaman, Najamuz. « Lincoln Motor Company : Case Study 2015 Lincoln—MKC ». Dans Automotive Electronics Design Fundamentals, 209–26. Cham : Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-17584-3_6.

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Bensard, Denis D., Philip F. Stahel, Jorge Cerdá, Babak Sarani, Sajid Shahul, Daniel Talmor, Peter M. Hammer et al. « MIC and MBC ». Dans Encyclopedia of Intensive Care Medicine, 1395. Berlin, Heidelberg : Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-00418-6_3204.

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Moritz, Steffen, Ruth Veckenstedt, Sarah Randjbar et Francesca Vitzthum. « MKT+ : Ein innovativer Ansatz ». Dans MKT+, 1–4. Berlin, Heidelberg : Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-19946-2_1.

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Moritz, Steffen, Ruth Veckenstedt, Sarah Randjbar et Francesca Vitzthum. « Schizophrenie ». Dans MKT+, 5–32. Berlin, Heidelberg : Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-19946-2_2.

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Moritz, Steffen, Ruth Veckenstedt, Sarah Randjbar et Francesca Vitzthum. « Theoretische Annahmen : Kognitive Verzerrungen bei Wahn ». Dans MKT+, 33–47. Berlin, Heidelberg : Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-19946-2_3.

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Moritz, Steffen, Ruth Veckenstedt, Sarah Randjbar et Francesca Vitzthum. « Individualisiertes Metakognitives Therapieprogramm (MKT+) ». Dans MKT+, 49–58. Berlin, Heidelberg : Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-19946-2_4.

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Moritz, Steffen, Ruth Veckenstedt, Sarah Randjbar et Francesca Vitzthum. « Anleitung zur Durchführung der Therapieeinheiten ». Dans MKT+, 59–119. Berlin, Heidelberg : Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-19946-2_5.

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Moritz, Steffen, Ruth Veckenstedt, Sarah Randjbar et Francesca Vitzthum. « Probleme und Lösungsmöglichkeiten ». Dans MKT+, 121–24. Berlin, Heidelberg : Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-19946-2_6.

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Veckenstedt, Moritz, et Randjbar Vitzthum. « THERAPIEEINHEIT 8 : GEDÄCHTNIS ». Dans MKT+, 355–405. Berlin, Heidelberg : Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-19946-2_7.

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Veckenstedt, Moritz, et Randjbar Vitzthum. « THERAPIEEINHEIT 9 : SELBSTWERT UND STIMMUNG ». Dans MKT+, 409–81. Berlin, Heidelberg : Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-19946-2_8.

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Actes de conférences sur le sujet "MKC"

Paulus, J. M., R. Fernandez-Delgado, J. C. Grosdent, J. Lecocq et M. Prenant. « ON THE DOUBLING DISTRIBUTIONS OF DAY 7-MEGAKARYOCYTE (MKC) PROGENITORS ». Dans XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643540.

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It has often been assumed that hemopoietic progenitors undergo a rather uniform, deterministic number of proliferative cycles before they generate the elements which are recognizable by pano-ptiG and cytochemical methods. We now confirm and extend previous data on the distribution of the number of doublings undergone before polyploi'dization by day 7-MKC progenitors. Cultures of mouse bone marrow were stimulated by erythropoietin, WEHI conditioned medium (CM) and/or pokeweed CM. In all cases, cumulative doubling distributions of pure MKC colonies could be precisely fitted by exponential lines, whose slope and length depended on the stimulus or combination of stimuli used. The frequency of single MKC could be fitted by the same line as that plotting the number of doublings in MKC colonies, suggesting that single MKC and MKC colonies can be generated by the same class of progenitors. Exponential shape implies that the coefficient of variation (SD/mean) of doubling numbers is one, indicating significant variability in proliferative behavior among day 7-MKC progenitors. Such exponential distributions are best explained in the framework of Renewal Theory (Cox, Methuen, 1962). Whatever the distribution of the number of progenitor renewals in fixed time, the distribution of renewals will be geometric (i.e discontinuous exponential) if the total time spent by individual colonies in the proliferation phase (1) is distributed exponentially, and (2) is independent from the renewal process itself. These results suggest that the wave of MKC progenitor mitoses is randomly arrested by a differentia-tive event which strikes progenitor clones independently from their proliferative past.

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Wang, Yueqing, Xinwang Liu, Yong Dou et Rongchun Li. « Multiple Kernel Clustering Framework with Improved Kernels ». Dans Twenty-Sixth International Joint Conference on Artificial Intelligence. California : International Joint Conferences on Artificial Intelligence Organization, 2017. http://dx.doi.org/10.24963/ijcai.2017/418.

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Multiple kernel clustering (MKC) algorithms have been successfully applied into various applications. However, these successes are largely dependent on the quality of pre-defined base kernels, which cannot be guaranteed in practical applications. This may adversely affect the clustering performance. To address this issue, we propose a simple while effective framework to adaptively improve the quality of these base kernels. Under our framework, we instantiate three MKC algorithms based on the widely used multiple kernel $k$-means clustering (MKKM), MKKM with matrix-induced regularization (MKKM-MR) and co-regularized multi-view spectral clustering (CRSC). After that, we design the corresponding algorithms with proved convergence to solve the resultant optimization problems. To the best of our knowledge, our framework fills the gap between kernel adaption and clustering procedure for the first time in the literature and is readily extendable. Extensive experimental research has been conducted on 7 MKC benchmarks. As is shown, our algorithms consistently and significantly improve the performance of the base MKC algorithms, indicating the effectiveness of the proposed framework. Meanwhile, our framework shows better performance than compared ones with imperfect kernels.

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Wang, Yueqing, Xinwang Liu, Yong Dou et Rongchun Li. « Approximate Large-scale Multiple Kernel k-means Using Deep Neural Network ». Dans Twenty-Sixth International Joint Conference on Artificial Intelligence. California : International Joint Conferences on Artificial Intelligence Organization, 2017. http://dx.doi.org/10.24963/ijcai.2017/419.

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Multiple kernel clustering (MKC) algorithms have been extensively studied and applied to various applications. Although they demonstrate great success in both the theoretical aspects and applications, existing MKC algorithms cannot be applied to large-scale clustering tasks due to: i) the heavy computational cost to calculate the base kernels; and ii) insufficient memory to load the kernel matrices. In this paper, we propose an approximate algorithm to overcome these issues, and to make it be applicable to large-scale applications. Specifically, our algorithm trains a deep neural network to regress the indicating matrix generated by MKC algorithms on a small subset, and then obtains the approximate indicating matrix of the whole data set using the trained network, and finally performs the $k$-means on the output of our network. By mapping features into indicating matrix directly, our algorithm avoids computing the full kernel matrices, which dramatically decreases the memory requirement. Extensive experiments show that our algorithm consumes less time than most comparatively similar algorithms, while it achieves comparable performance with MKC algorithms.

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Karandasheva, V. O., et L. I. Grechkina. « Characterization of the hemodynamic parameters of adolescent boys in the city of Magadan depending on the somatotype ». Dans XXV REGIONAL SCIENTIFIC CONFERENCE STUDENTS, APPLICANTS AND YOUNG RESEARCHERS. Знание-М, 2020. http://dx.doi.org/10.38006/907345-63-8.2020.148.154.

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The work was carried out on male students aged 11–14 years living in Magadan. Studies have shown that adolescents with macrosomatotype in all age groups significantly exceed their peers with meso-and microsomatotype in terms of systolic blood pressure, cardiac output and shock volume. The most significant differences were found between groups with Mac and Mic, and individuals with Mec occupy an intermediate position in the studied indicators.

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Turek, Steven, et Sam Anand. « A Comparison of Virtual Condition Cylinder Evaluation Methods in Coordinate Metrology ». Dans ASME 2008 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2008. http://dx.doi.org/10.1115/detc2008-49798.

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When a cylindrical datum feature is specified at maximum material condition (MMC) or least material condition (LMC) a unique circumstance arises: a virtual condition (VC) cylindrical boundary must be defined [1]. The geometric relationship between a cylindrical point cloud obtained from inspection equipment and a VC cylinder has not been specifically addressed in previous research. In this research, novel approaches to this geometric analysis are presented, analyzed, and validated. Two of the proposed methods are new interpretations of established methods applied to this unique geometric circumstance: least squares and the maximum inscribing cylinder (MIC) or minimum circumscribing cylinder (MCC). The third method, the Hull Normal method, is a novel approach specifically developed to address the VC cylinder problem. Each of the proposed methods utilizes a different amount of sampled data, leading to various levels of sensitivity to sample size and error. The three methods were applied to different cylindrical forms, utilizing various sampling techniques and sample sizes. Trends across sample size were analyzed to assess the variation in axial orientation when compared to the true geometric form, and a relevant case study explores the applicability of these methods in real world applications.

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Hornfeld, Willi. « ATLAS AUVs for Offshore Applications : Status and Perspectives ». Dans ASME 2005 24th International Conference on Offshore Mechanics and Arctic Engineering. ASMEDC, 2005. http://dx.doi.org/10.1115/omae2005-67215.

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The scientific and economic significance of underwater technology is considerable, particularly as the oceans are becoming more and more important not only as a source of energy, raw materials and food but also due to their influence on climatic changes. Underwater technology, especially at great depths, represents a very particular challenge which is being tackled by ATLAS ELEKTRONIK Autonomous Underwater Vehicles (AUVs) DeepC©, SeaOtter Mk1 and SeaOtter Mk2. Many actions that would normally require high cost ROV systems or which are not possible (e.g. under ice investigations) can now accomplished using AUVs, at less cost and manpower. DeepC© is a high efficient AUV system for ultra deep missions (4000m), with long endurance (40–60h) and for a lot of applications. The development objectives are: Low vehicle weight, modular design, high efficient energy generation, autonomous mission execution, obstacle avoidance, in mission re-planning capability, precise navigation, advanced diagnosis and fault recovery system, high manoeuvrability, hover capability and containerized payload. The system is final integrated and ready for water tests and demonstrations till end of 2004. The paper deals with the system performance and shows the development status. The AUV SeaOtter Mk1, based on the ATLAS Maridan M600 vehicle and adapted to modern requirements in navigation software and mission management, is the ideal payload sensor carrier for military and commercial purposes. It ensures precise positioning, stability and manoeuvrability for accurate data collection. The on-board system provides all necessary position, attitude, status and time information to ensure effective and efficient performance throughout the mission. High positional accuracy and accurate stabilization of the vehicle’s attitude throughout the collection of data allows the mapping of raw data to be implemented directly, without post-processing, to obtain the necessary correlation of the survey mosaic. The advanced version of the SeaOtter AUV, the Mk2 is designed for various purposes, strictly adhering to a modular approach with regard to superstructure, propulsion, energy, communication, navigation and payload. The basic vehicle can easily be extended by the means of one or two extension modules to carry heavier payloads. The paper shows the SeaOtter Mk1 performance and gives an overview over the Mk2 Philosophy and the development status.

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Gladwin, A. W., E. A. Trowbridge, D. N. Slater, J. M. Adams et J. Martin. « ABNORMALITIES OF MEGAKARYOCYTE (MK) SIZE AND MORPHOLOGY IN PRIMARY AND SECONDARY THROMBOCYTOSIS ». Dans XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643541.

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Platelet count elevations are observed in various clinical situations. In essential thrombocythaemia (ET), this is believed to reflect a primary disorder of megakaryocytes (MK). In contrast, thrombocytosis in malignant lymphoma (ML) is thought to arise via a secondary effect on these cells. In this study, MK parameters of whole cell, cytoplasmic and nuclear volumes were evaluated in these disorders. A trephine biopsy was obtained from the iliac crest of 10 subjects with ET, and from 10 subjects with ML. All exhibited a thrombocy^osip (considered to be a platelet count in excess of 400×109 L−1 ). In addition, a biopsy was obtained from 5 volunteer, haematologically normal subjects. Platelet counts in all subjects were measured using Coulter S+. Biopsies were processed as described elsewhere( 1). MK and MK nuclear planimetric areas were measured and converted to associated volumes(l). Mean MK, MK cytoplasmic and nuclear volumes were significantly larger in ET(p<0.05)and ML(p<0.05) when compared to those in controls. In addition, MKs in ET showed morphological abnormalities which were not exhibited in ML. These results suggest that platelet count elevations in ML and ET arise from large MKs with increased amounts of cytoplasm. The increased nuclear size observed further suggests that this may be mediated by an increased DNA content.

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Kobayashi, Isao, et Mitsutoshi Nakajima. « Micro/Nanochannel Emulsification for Generating Monosize Droplets ». Dans ASME 2012 Third International Conference on Micro/Nanoscale Heat and Mass Transfer. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/mnhmt2012-75238.

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Emulsification is an important process in various fields including foods, pharmaceuticals, cosmetics, and chemicals. Emulsification operation is commonly conducted using conventional emulsification devices, such as high-speed blenders, colloid mills, high-pressure homogenizers, and ultrasonic homogenizers. However, these emulsification devices result in the production of polydisperse emulsions with wide droplet size distributions and poor controllability in droplet size and its distribution. In contrast, monodisperse emulsions consisting of monosize droplets have received a great deal of attentions over the past decade due to their high-tech applications, e.g., monosize microparticles as spacers for electronic devices and monosize micro-carriers for drug delivery systems (DDS). Our group proposed microchannel (MC) emulsification as a promising technique to produce monodisperse emulsions in the mid 1990s. Micro/Nanochannel (MNC) emulsification enables generating monosize droplets with the smallest coefficient of variation (CV) of below 5% using MC and nanochannel (NC) arrays of unique geometry. The resultant droplet size, which ranged from 0.5 to 200 μm, can be precisely controlled by channel geometry. Droplet generation for MNC emulsification is very mild and does not require any external shear stress; a dispersed phase that passed through channels is transformed spontaneously into monosize droplets inside a continuous-phase domain. The aim of this paper is to present recent developments in MNC emulsification chips, particularly focusing on asymmetric straight-through MC arrays for large-scale production of monodisperse emulsions. Asymmetric straight-through MC array chips were fabricated using a silicon-on-insulator wafer. Numerous asymmetric straight-through MCs each consisting of a microslot and a narrow MC were positioned in the central region of the chip. Monosize droplets were stably generated via asymmetric straight-through MCs at high production rates. Below a critical droplet production rate, monosize droplets were generated via asymmetric straight-through MCs, with droplet size and size distribution independent of the droplet productivity. The use of a large asymmetric straight-through MC array chip achieved the mass production of monosize tetradecane oil droplets at ∼1 L/h. The simulation results using CFD (computational fluid dynamics) agreed well with the experimental results and provided useful information, such as the movement of the oil-water interface during droplet generation. Monosize submicron droplets were also obtained using NC emulsification chips made of single-crystal silicon.

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Ahmed, Sheikh Sharif, Bipul Hawlader et Kshama Roy. « Finite Element Modeling of Large Diameter Monopiles in Dense Sand for Offshore Wind Turbine Foundations ». Dans ASME 2015 34th International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/omae2015-42218.

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With increasing demand of energy, attention to the alternative sources of sustainable energy is getting priority over the last decades. Offshore wind turbine is one of them. The most widely used foundation system for the wind turbine is the monopile, which is a large diameter single pile. In the present study, three-dimensional finite element (FE) analyses are performed to evaluate the capacity of large diameter monopiles in dense sand using the Arbitrary Lagrangian-Eulerian (ALE) approach available in Abaqus/Explicit FE software. The behavior of sand is modeled using the Mohr-Coulomb (MC) and a modified Mohr-Coulomb (MMC) model where the pre-peak hardening, post-peak softening and the effects of mean effective stress and relative density on stress-strain behavior of dense sand are considered. Comparison with physical model test results shows that the MMC model can simulate better the load-displacement response than that with the MC model. The mechanisms involved in soil deformation are also explained using FE results.

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Karacam, Meryem, et Durmus Alpaslan Kaya. « The effect of some essential oils on pathogenes that cause eczema ». Dans The 8th International Conference on Advanced Materials and Systems. INCDTP - Leather and Footwear Research Institute (ICPI), Bucharest, Romania, 2020. http://dx.doi.org/10.24264/icams-2020.ii.13.

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In this study, the antimicrobial activity of essential oils obtained from Thymbra spicata L., Lavandula angustifolia Mill. and Myrtus communis L. on the pathogens causing eczema Staphylococcus aureus (ATCC 29213), Staphylococcus epidermidis (ATCC 12228), Escheria coli (ATCC 25922), Acinetobacter baumannii (ATCC 43498), Pseudomonas aeruginosa (ATCC 27853) ve Candida albicans (ATCC 90028) were investigated. The MIC and MBC values of the essential oils used in the study against the pathogens causing eczema were determined. As a result of the results obtained, antimicrobial activity of plant essential oils used in the study on test microorganisms was determined. Among the essential oils, it was found that the most effective essential oil was thyme followed by the lavender.

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Rapports d'organisations sur le sujet "MKC"

Wade, J. A. Lithostratigraphy 4 : Mic Mac and Abenaki formations. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 1991. http://dx.doi.org/10.4095/210641.

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Avery, M. P. Vitrinite Reflectance (Ro) of Dispersed Organics From Shell Mic Mac H-86. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 1986. http://dx.doi.org/10.4095/130222.

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Lajoie, John. PHENIX Muon Piston Calorimeter (MPC) APD and Prototype MPC Extension (MPC-EX) Tests. Office of Scientific and Technical Information (OSTI), juin 2013. http://dx.doi.org/10.2172/1128068.

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García Salamanca, Angela Viviana, Julieth Nataly Lesmes et Andrés Felipe Ruiz Castro. Prospectiva de la formación en salud universitaria. Universidad Nacional Abierta y a Distancia - UNAD, 2019. http://dx.doi.org/10.22490/ecisa.4762.

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El estudio que se presenta a continuación tiene como objetivo realizar un estudio prospectivo para la Escuela de Ciencias de la Salud de la Universidad Nacional Abierta y a Distancia UNAD con un horizonte de tiempo al año 2026. Desarrollo. Su metodología se diseñó bajo un enfoque cualitativo de tipo descriptivo. El eje principal en el que se fundamentó el desarrollo de la investigación se enfocó en los postulados prospectivos de la escuela francesa representada por Michel Godet adaptado a los requerimientos del estudio en particular de la formación en salud. El procedimiento se dividió en tres etapas: Primera etapa, encuesta Delphi, busca determinar avances tecnológicos y tendencias de la educación en salud, Segunda etapa. Análisis estructural por medio del método MIC-MAC, Tercera etapa. Diseño de escenarios futuros y propuesta de escenario apuesta utilizando el método de ejes de Peter Schwartz. Conclusiones: Se evidenciaron cinco objetivos estratégicos para la formación en salud, como son: tecnosalud, infraestructura, investigación, redes académicas y transdisciplinariedad. Los ejes estratégicos permitieron diseñar cuatro posibles escenarios para la prospectiva en la formación en salud.

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Jung, Yeon Sang, Changho Lee et Micheal A. Smith. PROTEUS-MOC User Manual. Office of Scientific and Technical Information (OSTI), septembre 2018. http://dx.doi.org/10.2172/1483947.

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O'Neal, Thomas, et Robin Phelps. Megawatt Cleantech Challenge (MCC). Office of Scientific and Technical Information (OSTI), novembre 2018. http://dx.doi.org/10.2172/1596016.

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Michael Cannon, Terry Barney, Gary Cook, Jr George Danklefsen, Paul Fairbourn, Susan Gihring et Lisa Stearns. MFC Communications Infrastructure Study. Office of Scientific and Technical Information (OSTI), janvier 2012. http://dx.doi.org/10.2172/1035903.

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Pillai, Shiv S. MHC Genes and Breast Cancer. Fort Belvoir, VA : Defense Technical Information Center, septembre 2000. http://dx.doi.org/10.21236/ada394028.

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Whiting, D., R. Housley et N. Ferguson. Counter with CBC-MAC (CCM). RFC Editor, septembre 2003. http://dx.doi.org/10.17487/rfc3610.

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Marin-Lafleche, A., M. A. Smith, E. E. Lewis et C. H. Lee. Development status of PROTEUS-MOC. Office of Scientific and Technical Information (OSTI), novembre 2012. http://dx.doi.org/10.2172/1054500.

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