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Bibliographies thématiques / Molecular biology, Hematopoiesis, Gene regulation / Thèses

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Thèses sur le sujet « Molecular biology, Hematopoiesis, Gene regulation »

Auteur : Grafiati

Publié le 9 mars 2023

Mis à jour le 31 juillet 2025

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1

CANTU', CLAUDIO. "The Sox6 transcription factor: its role in human and murine erythroid differentiation and mechanisms for its regulation." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2009. http://hdl.handle.net/10281/8374.

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To identify new genes functionally involved in erythropoiesis during development and maturation, we analysed by DNA microarray three cell populations of different maturity during mouse fetal liver development (E11.5 - E13.5). Among genes whose expression increases in parallel with erythroid maturation there is Sox6, a member of the Sry–related transcription factors family. Sox6 is known to play a major role in erythropoiesis: its ablation in mouse causes a strong relative increase of the expression of embryonic (εy) versus other non-alpha globin genes in late gestation, and a high number of

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Martin, Richard. "Regulation of SCL expression and function in hematopoiesis." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=85582.

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The development of the hematopoietic system occurs in two waves: a first wave of primitive erythropoiesis, which consists in the production of a single lineage, primitive erythrocytes, and a second wave of definitive hematopoiesis, which describes the generation of many specialized blood cell types from common hematopoietic stem cells. Whereas definitive hematopoiesis is fairly well understood, involves signals from the environment and the expression of lineage-specific transcription factors, the molecular mechanisms regulating primitive erythropoiesis remain to be defined. The aim of t

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Xu, Yong Zhong. "Molecular mechanisms of regulation of SLC11A1 gene expression." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=121167.

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Solute carrier family 11 member 1 protein (SLC11A1), also known as natural resistance-associated macrophage protein 1 (NRAMP1), plays an important role in the host immune defense and inflammatory response. It is a highly conserved transmembrane protein which transports divalent metal cations in a proton-dependent manner. It regulates iron homeostasis in macrophages and exerts pleiotropic effects on macrophage activation. In mice, natural resistance or susceptibility to a range of intracellular pathogens is controlled by the Slc11a1 gene. In human, genetic polymorphisms of the SLC11A1 gene have

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Sutherland, Leslie C. "Transcriptional regulation of the murine PGK-1 gene." Thesis, University of Ottawa (Canada), 1994. http://hdl.handle.net/10393/10111.

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The gene encoding the glycolytic enzyme phosphoglycerate kinase is transcriptionally regulated at two levels. Expression of enzyme is related to the glycolytic activity of the cell, and is highest in transcriptionally active cells. Expression is also regulated by X chromosome inactivation, as the somatically expressed Pgk-1 gene is X-linked. The role of 5$\sp\prime$-flanking cis-acting DNA elements and trans-acting factors in the regulation of Pgk-1 expression was examined. The murine Pgk-1 gene contains an upstream activator sequence (UAS) in its 5$\sp\prime$-flanking region. This region was

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Bakopanos, Evangelos. "Regulation of the 3-adrenergic receptor gene expression." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=38148.

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The beta3-adrenergic receptor (beta3-AR) represents a very attractive target for the development of anti-obesity drugs. Selective agonists have been developed based on the rodent beta3-AR and successfully used to treat obesity and Type 2 diabetes in these animals. In humans, however, these particular compounds appear to be less effective and not as specific for the beta3-AR as they are in rodents. An additional problem is the low level of expression of these receptors in human adipose, which may ultimately limit the clinical use of stronger more specific agonists. The objective of this researc

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Argentin, Stefania. "Transcriptional regulation of the rat atrial natriuretic factor gene." Thesis, McGill University, 1990. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=74556.

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Atrial natriuretic factor (ANF), a 28 amino acid peptide hormone, is the major secretory product of the heart. Because of its diuretic, natriuretic and vasodilating activities, this peptide may be involved in the maintenance of proper fluid and electrolyte balance and blood pressure control. In order to study the transcriptional regulation of ANF, we have isolated the rat ANF gene and we have established a system of cardiocytes in primary cell culture for studies on the hormonal, tissue-specific and developmental regulation of the ANF gene. Using this in vitro system, as have demonstrated that

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Bales, Mark. "Molecular regulation of gene expression in anterior mesendoderm of vertebrates." Diss., The University of Arizona, 2002. http://hdl.handle.net/10150/280000.

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The signaling pathways that regulate the fate of cells located in the anterior lateral (AL) region of the vertebrate embryo are not well understood. Mesodermal cells in this region will assume the heart muscle phenotype while adjacent endoderm gives rise to foregut tissues such as the liver. The AL endoderm supplies key signaling molecules to promote the survival and differentiation of the precardiac mesoderm. These AL endoderm factors are know to up-regulate transcription factors, such as Nkx2--5, that regulate cardiac genes. However, little is known about how the AL endoderm is patterned and

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Lefebvre, Tania. "Role of USP4 in the regulation of gene expression." Thesis, University of Ottawa (Canada), 2007. http://hdl.handle.net/10393/27471.

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USP4 is a deubiquitinating enzyme whose levels have been shown to be elevated in certain human lung tumors. USP4 is thought to possess oncogenic properties due to its ability to promote tumors in nude mice assays. The lack of an overall effect on ubiquitin levels in overexpression studies has led to the hypothesis that USP4 may act on a few select substrates to edit their ubiquitination status. Although the structure/function relationship is more documented, the physiological substrates and role in vivo are not. In order to elucidate the mechanism by which USP4 could potentially exert its tumo

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Garnier, France. "Study of transcription regulation of the gene mdr1." Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=56986.

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In order to characterize cis-acting sequences and trans-acting factors important in regulating the expression of the mouse mdr1 gene, in vitro DNAsel footprinting experiments were carried out on a mdr1 promoter segment between positions $-$245 and +84, using nuclear protein extracts prepared from cell lines expressing different endogenous amounts of mdr1 mRNAs. Three footprinted sequences were detected on the non-coding strand of the $-$245 to +84 mdr1 promoter fragment (between -77 to -56, between -46 to -24, and between +5 and +15) with nuclear extracts from mdr1 expressing cells (CMT-93, LT

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Canaff, Lucie. "Extracellular calcium-sensing receptor : studies of gene expression and regulation." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=85136.

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The calcium-sensing receptor (CaSR), expressed in parathyroid, thyroid and kidney, is essential for maintenance of calcium homeostasis. Extracellular calcium (Ca2+o) affects several hepatic functions including bile secretion, metabolic activity, regeneration, and the response to xenobiotics. We have demonstrated the presence, in hepatocytes, of a functional CaSR. Western blot analysis using a specific CaSR antibody showed staining in both whole liver and hepatocyte extracts. Immunohistochemistry and in situ hybridization of rat liver sections showed expression of CaSR protein and mRNA b

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Bourbonnière, Martin. "Transcriptional regulation of the human b-amyloid precursor protein gene." Thesis, McGill University, 1997. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=34702.

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The beta-amyloid precursor protein (APP) is an extensively processed membrane protein with a single membrane spanning domain. One of the natural proteolytic products of APP is a peptide of 39 to 43 amino acids in length, beta-amyloid, that has been identified as a major constituent of senile plaques, a neuropathological hallmark of Alzheimer disease (AD). In Down syndrome (DS) (trisomy 21), overexpression of the APP gene, located on chromosome 21, is thought to be responsible for the early formation of senile plaques in the brain of DS patients. We investigated the transcriptional regulation o

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De, Guise Chantal. "Regulation of Pit-1 gene expression by activin in pituitary cells." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111923.

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Prolactinomas account for 40% of all tumors in the pituitary, an important gland of the endocrine system, and secrete excess amount of prolactin hormone. We recently identified a member of the TGF-beta superfamily of growth factors, activin, as an important regulator of prolactin expression and cell growth. Activin inhibits prolactin expression through inhibition of expression of a pituitary-specific transcription factor, named Pit-1. Pit-1 plays major roles in the development and maintenance of the anterior pituitary gland integrity. In this study, I investigated the intracellular signaling p

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Fields, Paul A. "H2A.Z : a molecular rheostat for gene regulation in embryonic stem cells." Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/101349.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 2015.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Chromatin regulation is a key mechanism for controlling gene expression patterns during development and differentiation. The histone H2A variant H2A.Z is highly conserved among eukaryotes and is of particular interest because it has an essential, yet unknown role in early development. H2A.Z is enriched at the promoter regions of most genes that harbor H3K4me3 in mouse embryonic stem cells (mESCs) including both active and silent

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Ensterö, Mats. "The multi-faceted RNA molecule : Characterization and Function in the regulation of Gene Expression." Doctoral thesis, Stockholm University, Department of Molecular Biology and Functional Genomics, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-7729.

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<p>In this thesis I have studied the RNA molecule and its function and characteristics in the regulation of gene expression. I have focused on two events that are important for the regulation of the transcriptome: Translational regulation through micro RNAs; and RNA editing through adenosine deaminations.</p><p>Micro RNAs (miRNAs) are ~22 nucleotides long RNA molecules that by semi complementarity bind to untranslated regions of a target messenger RNA (mRNA). The interaction manifests through an RNA/protein complex and act mainly by repressing translation of the target mRNA. I have shown that

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Rouleau, Julie. "Regulation of the mouse DNA methyltransferase gene expression." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=29122.

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A hallmark of DNA methylation is the fact that 60 to 80% of CpG dinucleotide sequences in the vertebrate genome are methylated at the 5th-position of cytosine while the remaining unmethylated sequences are nonrandomly distributed throughout the genome generating a pattern of methylation that is both tissue and gene specific. Several lines of evidence suggest that methylation patterns correlate with the expression level of eukaryotic genes and that DNA methylation plays an important role in regulating the state of differentiation of mammalian cells. The methylation of DNA is catalyzed by the DN

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Lagacé, Monique. "Transcriptional regulation of rat carbamyl phosphate synthetase I gene." Thesis, McGill University, 1991. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=70204.

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The promoter region of the rat gene encoding the enzyme carbamyl phosphate synthetase I (CPS) has been cloned and characterized. The start of transcription was positioned to 138-140 nucleotides upstream of the translation initiation codon. From transient transfection analyses, the functional promoter region of the CPS gene extends 5$ sp prime$ to about 525 nucleotides of the start site of transcription. This promoter region contains six footprinted regions when analyzed in liver nuclear extracts. All sites can be recognized by endogenous C/EBP from liver nuclear extracts while the endogenous D

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Lee, Tae Ho 1968. "Transcriptional regulation by the Wilms' Tumor suppressor gene (WT1)." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=82913.

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Wilms' tumor (WT) is an embryonic renal neoplasm which affects 1 in 10,000 children. It has long been considered an excellent model for studying the relationship of cancer to development. A tumor suppressor gene wt1 , implicated in predisposition to WT, is known to play an essential role in regulating development of the kidney and of the genitourinary system. A number of genes involved in growth regulation and cellular differentiation are modulated by WT1 and a number of proteins are known to associate with WT1. Some of these proteins are able to alter the transcriptional properties of

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Li, Tong-Tong. "Molecular biology of cell reactions to surface topography." Thesis, University of Glasgow, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312506.

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Goping, Ing Swie. "Mechanisms of transcriptional regulation for the rat carbamyl phosphate synthetase I gene." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=28760.

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The proximal promoter of the rat carbamyl phosphate synthetase I gene contains 4 cis-acting regulatory regions, designated sites GAC, I, II, and III. Transient transfection assays revealed that the GAG element functions as the main activator element, whereas sites I and III bind repressor proteins and site II binds an anti-repressor. We propose that sites I and III repress the CPS I promoter either by quenching the sole activator(s) bound to the GAG element, or by directly repressing the basal transcription apparatus. Footprint analyses of the promoter with and without a mutation within site I

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Schiller, Benjamin J. "Data Biology| A quantitative exploration of gene regulation and underlying mechanisms." Thesis, University of California, San Francisco, 2013. http://pqdtopen.proquest.com/#viewpdf?dispub=3587899.

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<p> Regulation of gene expression is a fundamental biological process required to adapt the full set of hereditary information (i.e., the genome) to the varied environments that any organism encounters. Here, we elucidate two distinct forms of gene regulation – of endogenous genes by binding of transcription factors to information-containing genomic sequences and of selfish genes (“transposons”) by targeting of small RNAs to repetitive genomic sequences – using a wide array of approaches. </p><p> To study regulation by transcription factors, we used glucocorticoid rec

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Desfossés, Yan. "Regulation of HIV-1 gene expression by clade-specific Tat proteins." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=82221.

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The major group of HIV-1 viruses that comprises the current global pandemic evolved, during their worldwide spread, into at least 10 distinct subtypes or clades. Subtype C predominates in sub-Saharan Africa and is responsible for the majority of the worldwide HIV-1 infections, while subtype B predominates in North America and Europe and subtype A/E is prevalent in Southeast Asia. Functional distinctions in the arrangement of NF-kappaB elements within the long terminal repeat (LTR) among HIV-1 subtypes have been identified, thus raising the possibility that transcriptional divergence amo

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Nussenzveig, Roberto Henrique. "Approaches to understanding the regulation of trypsin gene expression in mosquitoes." Diss., The University of Arizona, 2001. http://hdl.handle.net/10150/279888.

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In order to identify potential cis-acting elements responsible for the correct expression of the mosquito trypsin genes we have resorted to an evolutionary approach. This approach is based on the identification of DNA footprints that are conserved in homologous genes isolated from different species. Several trypsin clones have been isolated from Aedes species specific genomic DNA libraries, and by sequencing been shown to contain an ORF coding for the late trypsin gene. Analysis of the 5' FLR's of the species specific late trypsin genes, reveals the presence of a conserved TATA-box and transcr

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Crippen, Craig Alexander. "Retinoic acid-independent regulation of RAR(beta)2 gene expression during cardiac development." Thesis, University of Ottawa (Canada), 1997. http://hdl.handle.net/10393/9528.

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RAR$\beta$ has been shown to be expressed in the developing heart at the 8 somite stage. Differentiation of EC cells with DMSO produces a mixture of embryonic cardiac, skeletal, endodermal and other mesodermal derivatives. The RAR$\beta$-2 isoform is predominantly expressed in the differentiated cardiac muscle cells. RT-PCR with isoform specific primers has been used to identify RAR$\beta$-2 as the predominant isoform. These results show, that like RA-treated EC cells, expression of the RAR$\beta$-2 isoform in DMSO differentiated P19 cells predominates. Stable transformants of the RARE$\beta$-

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Zogopoulos, George. "Regulation of growth hormone receptor gene expression during development." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0020/NQ44648.pdf.

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Kamath, Meghana B. "Reduced PU.1 concentrations lead to hematopoietic stem cell defects and lineage-inappropriate gene expression." University of Cincinnati / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1232633475.

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Bélanger, Valérie. "Circadian regulation of the mouse presenilin-2 gene : how is the molecular clockwork involved?" Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=97905.

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Several evidence indicate that presenilin-2 gene is rhythmically regulated in the mouse suprachiasmatic nuclei (SCN), which is the master circadian clock in mammals, as well as in the liver. We investigated the mechanism of circadian modulation behind presenilin-2 oscillation. CLOCK and BMAL1 are the two major transcription factors for circadian gene expression. We demonstrated that CLOCK and BMAL1 partially modulate presenilin-2 gene expression in vitro. In vivo, we showed that the gene does not oscillate in the muscle, spleen, thymus, heart and kidney. On the other hand, we demonstrated a ci

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Shock, Jennifer Leigh. "Genomic study of Plasmodium falciparum gene regulation and mechanisms of drug action and resistance." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3324572.

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Snetkova, Valentina. "Enhancers Cooperate to Exert Localized and Long-Range Control of Gene Regulation in Lymphocyte Development." Thesis, New York University, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10258886.

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<p> Enhancers are regulatory elements that orchestrate cell type specific gene expression patterns. They can be separated from their target genes by large distances and activate transcription by coming into physical proximity with promoters in three-dimensional nuclear space. Complex regulatory networks with multiple enhancers often cooperate to control the same target gene. Antigen receptor loci have proved to be a rich ground for understanding enhancer-mediated gene regulation. The loci undergo somatic recombination of their V, (D), J segments to create a diverse repertoire of antigen recept

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Happel, Christine. "Molecular Basis for Mu-Opioid Regulation of Chemokine Gene Expression." Diss., Temple University Libraries, 2009. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/28438.

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Molecular Biology and Genetics<br>Ph.D.<br>Opioid receptor modulation of pro-inflammatory cytokine production is vital for host defense and the inflammatory response. Previous results have shown the mu-opioid receptor (MOR) selective agonist, DAMGO, has the capacity to increase the expression of the pro-inflammatory chemokines, CCL2/MCP-1, CCL5/RANTES and CXCL10/IP-10 in peripheral blood mononuclear cells (PBMCs). We have shown that MOR activation is able to induce the expression of TGF-β, and TGF-β appears to be required for induction of CCL5 following MOR activation. This work suggests a nov

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Braunreiter, Kara M. "Regulation of Oscillatory Gene Expression by Alternative Polyadenylation." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1595517827933039.

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Nguyen, Hannah Anh-Quan. "Regulation of gene expression and cell growth by transcriptional proteins of the interferon system." Thesis, McGill University, 1998. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=35028.

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The Interferon Regulatory Factors (IRFs) are a family of interferon-inducible proteins which play distinct roles in diverse processes such as pathogen response, cytokine signalling, cell growth regulation and hematopoietic development. The objective of this research was to investigate the mechanisms by which IRF-1 and IRF-2 regulate gene expression and cell growth. Structure-function analyses of the IRF-2 protein demonstrate that transcriptional repression by IRF-2 is contained within the first 125 N-terminal amino acids and correlates directly with IRF-2 DNA binding. Overexpression of functio

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Liu, Jun-Li. "Transcriptional and post-transcriptional regulation of somatostatin gene expression by glucocorticoids." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=28826.

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Glucocorticoids and somatostatin both influence a broad spectrum of biological activities and their actions are cooperative in growth control, pancreatic islet function, immune suppression, and stress response, e.g. in vivo studies indicate that glucocorticoids may act through somatostatin to suppress growth, growth hormone secretion and inflammation. Recent studies have suggested that glucocorticoids influence somatostatin production but the precise nature of this effect has remained unclear. In this thesis, I characterized the actions of glucocorticoids on somatostatin gene expression and th

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Gardner, David Paul. "Epidermal growth factor receptor: Regulation of cellular proliferation and gene expression." Diss., The University of Arizona, 1993. http://hdl.handle.net/10150/186438.

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Binding of epidermal growth factor (EGF) to the EGF receptor stimulates the tyrosine kinase activity of the receptor and initiates a signal transduction cascade culminating in a mitogenic response. In many tumor derived cell lines which overexpress EGF receptor, exposure to EGF results in growth inhibition. The mechanism for this is unclear. This work involves analysis of growth inhibition by EGF, mechanisms of EGF receptor overexpression and regulation of the EGF receptor gene. The first two studies utilize a cell line (PC-10) that overexpresses EGF receptor without gene amplification. PC-10

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Xu, Hua. "Subcloning and regulation of a human intestinal sodium-phosphate cotransporter gene." Diss., The University of Arizona, 2001. http://hdl.handle.net/10150/284333.

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Phosphate plays a critical role in the body as a constituent of bone and tooth for body development, and as a urinary buffer for pH in body acid-base balance regulation. The phosphorus level in blood in human is between 3.0 to 4.5 mg/dl. When the blood phosphate concentration is lower than 2.5 mg/dl, the person develops hypophosphatemia. When the blood phosphate concentration is higher than 4.5 mg/dl, the person develops hyperphosphatemia. It is critically important for the body to control the phosphate level in blood and maintain the phosphate homeostasis. The kidney and the intestine are the

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Respuela, Patricia. "Gene Regulation and Epigenetic Mechanisms in the Parasite Trypanosoma cruzi." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-100265.

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Liao, Wenjuan. "CCDC3| A new p63 target gene involved in regulation of liver lipid metabolism." Thesis, Tulane University, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10244895.

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<p> TAp63, a member of the p53 family, has been shown to regulate energy metabolism. Here, we report coiled coil domain-containing 3 (CCDC3) as a new TAp63 target. TAp63, but not ΔNp63, p53 or p73, induces the expression of CCDC3 mRNA level by directly binding to the p63 consensus DNA binding sequence within the CCDC3 enhancer region. The CCDC3 expression is markedly reduced in TAp63-null mouse embryonic fibroblasts and brown adipose tissues and by tumor necrosis factor alpha that reduces p63 transcriptional activity but induced by metformin, an anti-diabetic drug that activates p63. Als

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Moore, Amy. "Coordinated regulation of heme biosynthesis and globin gene expression in erythroleukemia cells." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=79053.

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Nuclear factor-erythroid 2 (NF-E2) is a basic leucine zipper (bZIP) transcription factor that recognizes the DNA binding site [(T/C)GCTGA(G/C)TCA (T/C)] that contains a central AP-1 motif (underlined), but is distinct from AP-1 factors (Jun, Fos) due to the requirement of residues outside of the AP-1 core. NF-E2 is a heterodimer comprised of a cap'n'collar factor (p45) and a small Maf protein (MafF, G or K). It has been shown that NF-E2 promotes the opening of chromatin throughout the beta-globin loci, promoting gene expression and erythroid differentiation. Also, the p45 subunit is res

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Sabbagh, Laurent. "Transcriptional regulation of the murine caspase-3 gene during T cell activation." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84320.

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Caspases play an important role in shaping the developing organism. They are required to eliminate unwanted or damaged cells and therefore are able to prevent disease. Several reports have shown increased caspase-3 expression in different cell types undergoing apoptosis. We undertook to examine the role of T cell activation through the T cell receptor (TCR) in regulating caspase-3 gene expression. The KOX-14 murine T cell hybridoma was initially used as a model for activation-induced cell death. Caspase-3 mRNA levels increased by 3-fold following T cell activation and was independent of

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Wu, Yongjian 1969. "The regulation of apolipoprotein A-I gene expression: Dietary copper and zinc." Diss., The University of Arizona, 1996. http://hdl.handle.net/10150/290642.

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Copper (Cu) deficiency was induced in rats and Hep G2 cells by the use of a Cu-deficient diet and a cupruretic chelator, respectively. In the rat liver, Cu-deficiency did not alter the apo A-I mRNA abundance, but shifted significant amounts of mRNA to translationally more active fractions. These findings indicated that an increase in translational efficiency may contribute to the increase in hepatic apo A-I synthesis observed in Cu-deficient rats. In Hep G2 cells, Cu-depletion elevated the cytoplasmic apo A-I mRNA abundance by 1.5-fold. A 2.5-fold increased transcription rate and a 2-fold acce

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Benkel, Bernhard F. "Molecular cloning of Drosophila melanogaster amylase sequences and the regulation of amylase gene expression." Thesis, University of Ottawa (Canada), 1987. http://hdl.handle.net/10393/5385.

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Sato, Shinsuke. "Elucidation of the Molecular Mechanisms of Gene Expressions-Epigenetics Regulation by Chemical Biology." Kyoto University, 2020. http://hdl.handle.net/2433/258973.

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Clark, Erin Amelia. "New Mechanisms of Activation by Histone Demethylases in Gene Regulation." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11135.

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The epigenetic mechanisms that connect hormone signaling to chromatin remain largely unknown. Here we show that LSD1/KDM1A is a critical glucocorticoid receptor (GR) coactivator and report a previously unexplored mechanism where LSD1 activates gene transcription through H3K4me2 demethylation. We demonstrate that direct interaction of GR with LSD1 primarily inhibit its activity against H3K4me1 in vitro. While this interaction enables GR to recruit LSD1 in vivo and allows loss of H3K4me2, it impedes further demethylation. Thus resulting in conversion of H3K4me2 to H3K4me1 at enhancers and promot

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Aklilu, Fasika. "The regulation of parathyroid hormone-related protein (PTHRP) gene expression in hypercalcemia of malignancy /." Thesis, McGill University, 1999. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=35673.

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The studies included in this thesis were aimed at identifying the mechanisms that lead to aberrant expression of the PTHRP gene in cancer.<br>We have used the hepatocyte growth factor receptor oncogene, Tpr-Met, as a model and examined the effect of this oncogene on PTHRP expression. When transfected into Fisher rat 313 (Fr3T3) fibroblasts, Tpr-Met increased the transcription of PTHRP mRNA and secretion of the protein. To identify the signaling pathways involved we analyzed a mutant of Tpr-Met, Tyr489, that was impaired in activating a number of downstream effectors, including Phosphatidylinos

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Bradley, Evan. "Discovery and characterization of small non-coding RNAs in Vibrio cholerae that contribute to gene regulation during infection." Thesis, Sackler School of Graduate Biomedical Sciences (Tufts University), 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=3624938.

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<p> Small non-coding RNAs (sRNAs) are being increasingly recognized as critical regulators of a wide variety of processes in bacteria. To investigate the contribution of unknown sRNAs to virulence gene regulation in <i>Vibrio cholerae,</i> we undertook a screen to identify previously uncharacterized sRNAs under the control of the major virulence gene activator in <i> V. cholerae,</i> ToxT. Using a combination of direct sRNA cloning and sequencing together with a genome-wide ToxT <i>in vitro</i> binding assay, we identified 18 putative ToxT-regulated sRNAs. Two of these ToxT regulated sRNAs wer

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Terpening, Christopher Miles. "Analysis of transcriptional regulation of the rat bone gla protein gene by 1,25-dihydroxyvitamin D3: Receptor biochemistry and gene interactions." Diss., The University of Arizona, 1991. http://hdl.handle.net/10150/185381.

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The secosteroid hormone 1, 25-dihydroxyvitamin D₃ (1,25(OH)₂D₃) exerts its effects through a receptor protein which is a member of a superfamily of steroid receptor proteins. The 1,25(OH)₂D₃ receptor protein (VDR) binds both hormone and DNA with high affinity , thereby transcriptionally regulating the expression of a number of genes. A fragment of the cDNA to the human VDR containing essentially the entire open reading frame was transcribed and translated in vitro. demonstrated to exhibit The resulting protein was then the physical and functional features, i.e. molecular weight, immunoreactivi

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Wang, Hong. "Regulation of the plant one-carbon metabolic pathway and global gene responses in maize under salt stress." Diss., The University of Arizona, 2001. http://hdl.handle.net/10150/289752.

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One-carbon (C₁) metabolism. C₁ metabolism is central to all organisms, because C₁ units have essential roles in biosyntheses of basic materials for living cells, such as protein, nucleic acids, choline and its derivatives. One unique feature of plant C₁ metabolism is that it channels significant C₁ flux from primary carbon metabolism to methylated metabolites. Part I of this dissertation presents functional analysis of plant methyane-THF reductases (MTHFRs) in Arabidopsis and maize, and regulation of the plant C₁ metabolic pathway and glycine betaine (GlyBet) biosynthesis in maize GlyBet nea

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Discenza, Maria Teresa. "Regulation of expression of the Wilms' tumour 1 tumour suppressor gene." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=82855.

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Wilms' tumour, a pediatric kidney cancer that affects 1 in 10 000 children, is an excellent paradigm for studying the relationship between cancer and development. The Wilms' tumour suppressor 1 ( WT1) gene was identified through the study of hereditary cases of Wilms' tumour showing cytogenetic deletions at chromosome position 11p13. The WT1 gene encodes a zinc finger transcription factor necessary for the development of the genitourinary system. WT1 functions as an activator or a repressor, interacts with a number of different protein partners and regulates the expression of several ge

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Giannoukakis, Nick. "The genetic and epigenetic regulation of insulin-like growth factor II gene expression in humans." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0014/NQ36977.pdf.

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Roulston, Anne. "Regulation of NF-kB dependent cytokine gene expression in chronically HIV-1 infected myeloid cells." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=28902.

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Myeloid cells are important reservoirs of HIV-1 infection. In response to pathogenic agents, macrophages secrete inflammatory cytokines which can stimulate viral replication and contribute to AIDS pathogenesis. Two promonocytic cell models were used to investigate the relationship between NF-$ kappa$B dependent cytokine gene expression, differentiation, and HIV infection: the U937 and PLB-985 cell lines and their chronically infected counterparts U9-IIIB and PLB-IIIB. Chronic HIV-1 infection of U9-IIIB cells did not generally lead to constitutive transcription of cytokine genes. However, when

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Dufort, Daniel. "Characterization of a protein binding site involved in the regulation of transcription elongation within the murine c-myc gene." Thesis, McGill University, 1993. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=41580.

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The c-myc gene was previously shown to be regulated by a conditional block to transcription elongation and sequences from its promoter were implicated in this regulation. The objective of this project was to define the promoter elements involved in the control of transcription elongation. Using heterologous promoter constructs, the ME1a1 protein binding site located in the c-myc promoter was shown to be required for the block to transcription elongation. From mutation analysis, a correlation was established between the binding of nuclear factors to ME1a1 sites in vitro and the ability of these

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