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Littérature scientifique sur le sujet « Monoclonal »

Auteur : Grafiati

Publié le 4 juin 2021

Mis à jour le 25 juillet 2025

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Articles de revues sur le sujet "Monoclonal"

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Ernestho-ghoud, Indretsy Mahavivola, Moustafa Abdou Soilihi, Ny Ony Narindra Lova Hasina Rajaonarison, Nasolotsiry Enintsoa Raveloson, Ahmad Ahmad, and Hanta Marie Danielle Vololontiana. "Association entre gammapathie monoclonale de signification indéterminée et thrombose veineuse cérébrale : Une observation clinique inhabituelle." Annales Africaines de Medecine 16, no. 3 (2023): 5244–48. http://dx.doi.org/10.4314/aamed.v16i3.10.

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Cerebral venous thrombosis associated to the monoclonal gammopathy of undetermined significance has been rarely reported. In this paper, we discuss the case of 68-year-old man who presented repeated comitial. A cerebral Magnetic Resonance Imaging (MRI) showed cerebral venous thrombosis. The only biological abnormality highlighted was high level of monoclonal gammaglobulin. The coexistence of cerebral venous thrombosis and the monoclonal gammopathy of undetermined significance were fortuitous without causality links. French Abstract La thrombose veineuse cérébrale est rarement assoc

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Panda, Manasi. "Rabies-Monoclonal Antibody - A Perspective." Journal of Communicable Diseases 54, no. 03 (2022): 22–26. http://dx.doi.org/10.24321/0019.5138.202285.

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Rabies is an acute viral zoonotic disease that affects the central nervous system (CNS) of all warm-blooded animals, including mammals. Research studies and experience from across the world have demonstrated that appropriate administration of a combination of (a) local wound treatment, (b) anti-rabies vaccination and (c) passive immunization have proved to be quite effective in preventing the occurrence of rabies. As far as passive immunization is concerned, polyclonal plasma-derived rabies immunoglobulins (RIG) pose a number of limitations with scarce supply, high cost, etc. amongst many othe

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Bauvois, Adeline, Mélusine Larivière, Hervé Watier, and François Maillot. "Actualités des anticorps monoclonaux dans les maladies monogéniques aujourd’hui." médecine/sciences 35, no. 12 (2019): 1026–28. http://dx.doi.org/10.1051/medsci/2019203.

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Les maladies monogéniques sont des maladies génétiques rares mais très nombreuses, avec une sévérité variable. Les premières utilisations des anticorps monoclonaux dans ces maladies remontent aux années 2000 et de nombreux essais sont désormais en cours. Les anticorps monoclonaux anti-(interleukine)IL-1β ont profondément transformé la prise en charge des maladies auto-inflammatoires en modulant la composante inflammatoire et en diminuant le risque d’amylose secondaire ; les anticorps monoclonaux anti-TNF-α et anti-IL-6 sont également prescrits dans ces maladies. Dans le syndrome hémolytique et

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Fujita, T., T. Kamato, and N. Tamura. "Characterization of functional properties of C4-binding protein by monoclonal antibodies." Journal of Immunology 134, no. 5 (1985): 3320–24. http://dx.doi.org/10.4049/jimmunol.134.5.3320.

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Abstract We prepared mouse monoclonal antibodies to human C4-binding protein (C4-bp) by fusing spleen cells from mice immunized with purified C4-bp to the mouse myeloma line P3U1. Of four monoclonal antibodies that reacted with intact C4-bp, two were specific for a 48K fragment, one of the chymotryptic cleavage products of C4-bp, and one was specific for another fragment (160K). The fourth monoclonal antibody did not react with either fragment. One of the monoclonals that reacted with the 48K fragment blocked the binding of C4-bp to cell-bound C4b. This monoclonal antibody (TK3) also inhibited

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Velez, D., J. D. Macmillan, and L. Miller. "Production and use of monoclonal antibodies for identification of Bradyrhizobium japonicum strains." Canadian Journal of Microbiology 34, no. 1 (1988): 88–92. http://dx.doi.org/10.1139/m88-018.

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Thirteen murine hybridomas capable of producing monoclonal antibodies to somatic antigens on Bradyrhizobium japonicum were developed and an indirect enzyme-linked immunosorbent assay was used to test reactivity of the antibodies against 20 strains of B. japonicum. Although polyclonal antisera from mice immunized with strains of B. japonicum reacted with bacterial cells of all 20 strains, individual monoclonals were more specific. Some antibodies reacted with as few as 2 and one with as many as 11 strains. On the basis of reactivity with the set of 13 monoclonal antibodies, the 20 strains of B.

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Hanna, R. E. B., A. G. Trudgett, and A. Anderson. "Fasciola hepatica: development of monoclonal antibodies against somatic antigens and their characterization by ultrastructural localization of antibody binding." Journal of Helminthology 62, no. 1 (1988): 15–28. http://dx.doi.org/10.1017/s0022149x00011147.

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ABSTRACTA series of monoclonal antibodies was prepared against tegumental and internal antigens ofFasciola hepaticaby immunizing mice with whole adult-fluke homogenates prior to harvesting the splenic lymphocytes for fusion. Preliminary screening by the Indirect Fluorescent Antibody technique indicated the occurrence of discrete groups of monoclonals differing from one another in tissue-specificity but within which IFA labelling patterns were fairly consistent. Representative hybridomas for 5 of these groups were stabilized and used to produce ascites fluid in mice. By application of an immuno

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Lubkin, Margaret, Matthew Shallice, Julie Nyhus, Louis Leong, and Birte Aggeler. "Recombinant Rabbit Monoclonal Antibodies to Study Apoptosis and Apoptotic Pathways (132.4)." Journal of Immunology 184, no. 1_Supplement (2010): 132.4. http://dx.doi.org/10.4049/jimmunol.184.supp.132.4.

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Abstract Flow cytometry a tool for studying apoptosis and apoptotic pathways. Using monoclonal antibodies for flow cytometry leads to high specificity for the detection of the target epitope of interest, limiting the use of flow cytometry to available mouse monoclonal antibodies. Here we present high quality recombinant rabbit monoclonal antibodies that do not rely on hybridoma cell lines, but are made with a proprietary recombinant technology to obtain cloned antibodies. These rabbit monoclonals were compared to other available antibodies to demonstrate high specificity and affinity to their

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Campbell, AM, P. Whitford, and RE Leake. "Human monoclonal antibodies and monoclonal antibody multispecificity." British Journal of Cancer 56, no. 6 (1987): 709–13. http://dx.doi.org/10.1038/bjc.1987.275.

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Renu, Mariam Thomas. "Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposition: Report of Two Cases and Review of Literature." Archives of Renal Diseases and Management 2, no. 1 (2016): 037–39. https://doi.org/10.17352/2455-5495.000016.

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Here we report two cases of proliferative glomerulonephritis with monoclonal IgG deposits, a form of renal involvement by monoclonal gammopathy that mimics immune complex glomerulonephritis. Case 1 presented with incidental proteinuria and a renal biopsy showed mesangioproliferative glomerulonephritis with monoclonal IgG kappa deposits on immunofluorescence examination. He remains stable after one year follow up. Case 2 presented with rapidly progressive renal failure and renal biopsy showed rescentic membranoproliferative glomerulonephritis with monoclonal IgG kappa deposits on immunofluoresc

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Gyotoku, Y., M. Abdelmoula, F. Spertini, S. Izui, and P. H. Lambert. "Cryoglobulinemia induced by monoclonal immunoglobulin G rheumatoid factors derived from autoimmune MRL/MpJ-lpr/lpr mice." Journal of Immunology 138, no. 11 (1987): 3785–92. http://dx.doi.org/10.4049/jimmunol.138.11.3785.

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Abstract A MRL strain bearing the autosomal recessive mutant gene, lpr (lymphoproliferation), spontaneously develops, in addition to a lupus-like syndrome, unique serological and pathological manifestations. Production of high titers of IgG rheumatoid factors (RF) may be related to the formation of extremely large amounts of cryoglobulins and the development of tissue lesions such as necrotizing polyarteritis, arthritis, and glomerulonephritis. To analyze more directly the relationship of IgG RF to the development of cryoglobulins and tissue injuries, we have established four monoclonal IgG RF

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Thèses sur le sujet "Monoclonal"

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Austin, Eric B. "Human monoclonal antibodies." Thesis, University of Nottingham, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.276187.

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Xu, Wenbin. "Studies of antigenic relationships among spotted fever group rickettsiae by monoclonal antibodies." Aix-Marseille 2, 1997. http://www.theses.fr/1997AIX20665.

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Plumpton, Christopher. "Monoclonal antibodies against phytochrome." Thesis, University of Cambridge, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.358677.

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Fernandes, Carla Sofia. "Análise retrospectiva do achado de pico monoclonal em proteinogramas de rotina." Master's thesis, Universidade da Beira Interior, 2010. http://hdl.handle.net/10400.6/770.

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Introdução: As gamapatias monoclonais constituem um grupo heterogéneo de patologias, caracterizado pela proliferação monoclonal de plasmócitos que produzem e secretam imunoglobulina ou fragmentos desta. Na maioria das vezes, trata-se de uma entidade benigna, usualmente referida como gamapatia monoclonal de significado indeterminado. Contudo, esta pode evoluir para uma situação mais grave como o mieloma múltiplo ou outras gamapatias malignas. A detecção de componente monoclonal através de electroforese e a identificação por imunofixação sérica e/ou urinária de rotina são fundamentais para o seu

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Benjamin, Richard John. "Tolerance induction with monoclonal antibodies." Thesis, University of Cambridge, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.253988.

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Qin, Shi-Xin. "Transplantation tolerance with monoclonal antibodies." Thesis, University of Cambridge, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.305697.

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Heron, Andrew David. "The stability of monoclonal antibodies." Thesis, University of Glasgow, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.252169.

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Isaacs, John Dudley. "Improving serotherapy with monoclonal antibodies." Thesis, University of Cambridge, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386115.

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Paudel, Subhash. "Shear thinning in monoclonal antibodies." Thesis, Kansas State University, 2016. http://hdl.handle.net/2097/32833.

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Master of Science<br>Department of Physics<br>Jeremy D. Schmit<br>Antibodies are large Y-shaped proteins which are used by immune system to identify and neutralize pathogens. Monoclonal antibody therapy is used to treat different patient conditions. There are problems associated with the manufacturability and deliverability of mAb solutions due to the viscous nature of the protein. The viscosity of antibody solutions increases with the increase in concentration and decreases with applied shear. We want to know why these behaviours are seen and to address this problem we have developed a theory

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Ueda, Yasuji. "MONOCLONAL ANTIBODIES TO CHICK CRYSTALLINS." 京都大学 (Kyoto University), 1989. http://hdl.handle.net/2433/86412.

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Livres sur le sujet "Monoclonal"

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Ossipow, Vincent, and Nicolas Fischer, eds. Monoclonal Antibodies. Humana Press, 2014. http://dx.doi.org/10.1007/978-1-62703-992-5.

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Albitar, Maher, ed. Monoclonal Antibodies. Humana Press, 2007. http://dx.doi.org/10.1007/978-1-59745-323-3.

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Peters, Johann Hinrich, and Horst Baumgarten, eds. Monoclonal Antibodies. Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-74532-4.

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L, Beverley Peter C., ed. Monoclonal antibodies. Churchill Livingstone, 1986.

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P, Weizer William, Martineau William D, and Freedonia Group, eds. Monoclonal antibodies. Freedonia Group, Inc., 1991.

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Peter, Beverley, ed. Monoclonal antibodies. Churchill Livingstone, 1986.

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JoAnn, Edwards-Moulds, and Masouredis Serafeim P, eds. Monoclonal antibodies. American Association of Blood Banks, 1989.

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Davis, William C. Monoclonal Antibody Protocols. Humana Press, 1995. http://dx.doi.org/10.1385/0896033082.

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Borrebaeck, Carl A. K., and James W. Larrick, eds. Therapeutic Monoclonal Antibodies. Palgrave Macmillan UK, 1990. http://dx.doi.org/10.1007/978-1-349-11894-6.

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Steinitz, Michael, ed. Human Monoclonal Antibodies. Humana Press, 2014. http://dx.doi.org/10.1007/978-1-62703-586-6.

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Chapitres de livres sur le sujet "Monoclonal"

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Peters, J. H., and D. Baron. "Introduction." In Monoclonal Antibodies. Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-74532-4_1.

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Peters, J. H., M. Schulze, M. Grol, et al. "Demonstration of Monoclonal Antibodies." In Monoclonal Antibodies. Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-74532-4_10.

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Baron, D. "Safety Precautions at Work." In Monoclonal Antibodies. Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-74532-4_11.

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Peters, Johann Hinrich, and Horst Baumgarten. "Appendix." In Monoclonal Antibodies. Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-74532-4_12.

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Wiggenhauser, A., J. H. Peters, and H. Baumgarten. "Preconditions for Hybridoma Technology." In Monoclonal Antibodies. Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-74532-4_2.

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Baumgarten, H., M. Schulze, J. H. Peters, and T. Hebell. "Immunization." In Monoclonal Antibodies. Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-74532-4_3.

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Wiggenhauser, A., J. H. Peters, H. Baumgarten, and A. Borgya. "Taking Blood and Isolating Cells." In Monoclonal Antibodies. Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-74532-4_4.

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Peters, J. H., E. Debus, H. Baumgarten, R. Würzner, M. Schulze, and Helga Gerlach. "Cell Culture." In Monoclonal Antibodies. Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-74532-4_5.

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Baron, D., J. H. Peters, R. K. H. Gieseler, et al. "Production of Hybridomas." In Monoclonal Antibodies. Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-74532-4_6.

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Baumgarten, H., R. Franze, J. H. Peters, et al. "Mass Production of Monoclonal Antibodies." In Monoclonal Antibodies. Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-74532-4_7.

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Actes de conférences sur le sujet "Monoclonal"

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Clemetson, K. J., R. Weber, and J. L. McGregor. "TOPOLOGY OF PLATELET GPIb INVESTIGATED BY LOCATION OF MONOCLONAL ANTIBODY EPITOPES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643625.

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A large number of monoclonal antibodies to platelet membrane glycoprotein lb (GPIb) have been described but for most of these the position of the epitope is not known. Since many of these influence platelet function, a better understanding of struc-ture-function relationships requires this knowledge. The position of the epitopes for the monoclonal antibodies API (Dr. T.J. Kunicki), AN51 and SZ-2 (Dr. C-G. Ruan), WM23 (Dr. M.C. Berndt) and PI were determined by analysis of proteolytic cleavage fragments of glycocalicin via affinity chromatography on the monoclonal antibodies coupled to Sepharos

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Haak, Thalita, and Evelyn Helena Ascendino Honda. "Impacto da sensibilidade do exame de Cadeia Leve Livre Kappa e Lambda frente ao exame de Cadeia Leve Total Kappa e Lambda na detecção de proteína monoclonal: estimativa de subdiagnóstico de gamopatias monoclonais." In Resumos do 56º Congresso Brasileiro de Patologia Clínica/Medicina Laboratorial. Zeppelini Editorial e Comunicação, 2024. https://doi.org/10.5327/1516-3180.142s1.13185.

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Objetivo: A detecção da proteína monoclonal é utilizada como um importante biomarcador laboratorial para o diagnóstico de gamopatias monoclonais. Os principais exames utilizados para a detecção da Proteína M são: eletroforese (EPS), Cadeias Leves Livres Kappa e Lambda (CLL k e L) e Imunofixação no soro (EIS). De acordo com as diretrizes médicas nacionais e internacionais, o exame de Cadeia Leve Total Kappa e Lambda (CLT K e L) já não é mais recomendado para auxiliar no diagnóstico de gamopatias monoclonais devido à sua baixa sensibilidade. O objetivo deste estudo foi estimar o número de casos

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Hessing, Martin, Joost C. M. Meijers, Jan A. van Mourik, and Bonno N. Bouma. "MONOCLONAL ANTIBODIES TO HUMAN PROTEIN S AND C4b-BINDING PROTEIN." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644291.

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Protein S (PS) circulates in plasma both free and in reversible association with the complement component C4b-binding protein (C4bp). Only free PS is functional as a cofactor for activated protein C (APC). Cleavage of PS by thrombin at a site near the r-carboxyglutamic acid domain is associated with a loss of cofactor activity. This may be a control mechanism for the anticoagulant activity of APC. These observations led us to investigate the role of C4bp and thrombin in the regulation of PS. Complex formation between purified PS and C4bp was studied in plasma and in a system with purified comp

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DEL RIVERO, FRANCISCO BORJA, FRANCISCA GOMEZ, LUCIA CIVES, and GONZALO GARCIA. "Gammapatia monoclonal de significado renal." In XXIX Congreso Nacional de Medicina General y de Familia y V Jornadas SEMG Andalucía. Grupo Pacífico, 2023. http://dx.doi.org/10.48158/semg23-344.

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Sun, Yanjie, Zhuoyun Wan, and Zixiao Zhang. "Therapeutic Monoclonal Antibodies: Clinical Applications." In International Conference on Biotechnology and Biomedicine. SCITEPRESS - Science and Technology Publications, 2022. http://dx.doi.org/10.5220/0012020800003633.

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Santos, Isabelle Oliveira, Vanessa Severo de Lemos, Nathalia Mendes, et al. "Diagnóstico de mieloma múltiplo: a relevância da consistência laboratorial em um estudo de caso." In Resumos do 56º Congresso Brasileiro de Patologia Clínica/Medicina Laboratorial. Zeppelini Editorial e Comunicação, 2024. https://doi.org/10.5327/1516-3180.142s1.12222.

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Objetivo: O mieloma múltiplo é uma neoplasia de células plasmocitárias, caracterizada por proliferação clonal e produção de imunoglobulina monoclonal. A eletroforese de proteínas ainda é essencial para o diagnóstico e o manejo do mieloma múltiplo, permitindo a identificação da proteína monoclonal. Método: Trata-se de um relato de caso de paciente feminina, sem antecedentes patológicos, acompanhada desde 2017 por miomatose uterina e níveis elevados de antígeno carcinoembrionário (CEA), marcador tumoral associado a cânceres epiteliais, raramente descrito em mieloma múltiplo. Conclusão: A eletrof

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Berkner, J. A., G. Mitra, and J. W. Bloom. "MONOCLONAL ANTIBODY BINDING TO FACTOR VIII:C." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644063.

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The interactions of monoclonal antibodies with highly purified Factor VIII:c have been studied utilizing the ELISA technique. ELISA plates were coated with Factor VIII:c, protein A purified monoclonal IgG was then added and bound antibody detected with peroxidase labeled antimouse IgG. A Scatchard-Sips plot approach to data analysis was used to calculate binding constants. The binding constants for four antibodies designated BD10, AD7, C7F7 and 39MH8 were as follows: BD10, KO = 7.1 x 108 M-1, n = 1.1 (moles antibody/moles ligand); AD7, KO = 3.1 x 108 M-1, n = 2.7; C7F7, KO = 3.6 x 1011M-1, n =

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Chumak, N. S., and Y. I. Melnikova. "OBTAINING AND IMMUNOCHEMICAL TESTING OF APOFERRITIN." In SAKHAROV READINGS 2022: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY. International Sakharov Environmental Institute of Belarusian State University, 2022. http://dx.doi.org/10.46646/sakh-2022-1-289-293.

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The process of direct binding of monoclonal antibodies to apoferritin immobilized on polystyrene, as well as the method of competitive interaction of monoclonal antibodies with apoferritin in solution, have been experimentally studied. It was found that the immobilization of apoferritin on a polystyrene surface leads to a change in the epitope structure of this protein and to the elimination of reactive epitopes of binding of monoclonal antibodies. The soluble form of apoferritin effectively binds to monoclonal antibodies in a competitive assay, which confirms the conformational nature of the

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José, Gabriela Zanetti, and Carlos Alberto Mayora Aita. "Prevalência no Brasil de gamopatia monoclonal associada à nefropatia utilizando testes Freelite®." In Resumos do 56º Congresso Brasileiro de Patologia Clínica/Medicina Laboratorial. Zeppelini Editorial e Comunicação, 2024. https://doi.org/10.5327/1516-3180.142s1.10568.

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Objetivo: A gamopatia de significado renal é uma condição precursora do mieloma múltiplo e reagrupa todos os distúrbios renais causados por uma imunoglobulina monoclonal secretada por um clone de células B. Este estudo teve por objetivo compreender a eficiência dos testes Freelite® na triagem e no monitoramento de gamopatia monoclonal, e relacioná-la com o número de casos dessa condição associado à nefropatia em pacientes que apresentam maior suscetibilidade à doença, e observar a frequência de casos sugestivos de um laboratório de Sorocaba, São Paulo, durante o período de 1 ano e 6 meses. Mét

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Yang, Wu, Li-ming Wang, Zhao Wei, and Yuan Junlin. "Preliminary Production of Anti- Glufosinate Monoclonal Antibodies." In 2007 1st International Conference on Bioinformatics and Biomedical Engineering. IEEE, 2007. http://dx.doi.org/10.1109/icbbe.2007.18.

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Rapports d'organisations sur le sujet "Monoclonal"

1

Snyder, Christopher M., and Lawrence J. Wysocki. Dissecting Immunogenicity of Monoclonal Antibodies. Defense Technical Information Center, 2002. http://dx.doi.org/10.21236/ada407659.

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Snyder, Christopher M., and Lawrence J. Wysocki. Dissecting Immunogenicity of Monoclonal Antibodies. Defense Technical Information Center, 2003. http://dx.doi.org/10.21236/ada417364.

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Jaszczak, R. J. SPECT assay of radiolabeled monoclonal antibodies. Office of Scientific and Technical Information (OSTI), 1992. http://dx.doi.org/10.2172/7197646.

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Jaszczak, R. J. SPECT assay of radiolabeled monoclonal antibodies. Office of Scientific and Technical Information (OSTI), 1992. http://dx.doi.org/10.2172/7288347.

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Chia, John K. Polymyxin B(PMB)-Specific Monoclonal Antibodies. Defense Technical Information Center, 1991. http://dx.doi.org/10.21236/ada231817.

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Sato, J. D. Receptor Monoclonal Antibodies that Inhibit Tumor Angiogenesis. Defense Technical Information Center, 2001. http://dx.doi.org/10.21236/ada398146.

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Sato, J. D. Receptor Monoclonal Antibodies that Inhibit Tumor Angiogenesis. Defense Technical Information Center, 1999. http://dx.doi.org/10.21236/ada383129.

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Glassy, Mark C. Neutralizing Monoclonal Antibodies against Biological Toxins. Phase 1. Defense Technical Information Center, 1993. http://dx.doi.org/10.21236/adb176298.

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Basu, Sayani. Monoclonal Antibody Therapy: A New Hope in Cancer Treatment. Natur Library, 2020. http://dx.doi.org/10.47496/nl.blog.14.

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The remarkable specificity, high efficacy and the ability to elicit an antitumor response indicate that monoclonal antibody therapy offers promise in the treatment of malignancy and appears to be clinically relevant

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