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Littérature scientifique sur le sujet « Mucosal dysplasia »

Auteur : Grafiati

Publié le 7 juin 2025

Mis à jour le 2 août 2025

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Articles de revues sur le sujet "Mucosal dysplasia"

Ikebata, Akiyoshi, Masayuki Shimoda, Koji Okabayashi, et al. "Demarcated redness associated with increased vascular density/size: a useful marker of flat-type dysplasia in patients with ulcerative colitis." Endoscopy International Open 09, no. 04 (2021): E552—E561. http://dx.doi.org/10.1055/a-1352-2709.

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Abstract Background and study aims Recent advances in endoscopic equipment and diagnostic techniques have improved the detection of dysplasia in the inflamed mucosa of patients with ulcerative colitis (UC). However, it remains difficult to endoscopically identify flat-type dysplasia which has been formerly recognized as invisible dysplasia. Patients and methods In this retrospective, single-center study, we endoscopically identified 10 cases of flat-type-predominant dysplasia by targeted biopsy among 38 intramucosal dysplasia lesions from patients with UC who underwent surgical or endoscopic r

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Appelman, Henry D. "Adenocarcinoma in Barrett Mucosa Treated by Endoscopic Mucosal Resection." Archives of Pathology & Laboratory Medicine 133, no. 11 (2009): 1793–97. http://dx.doi.org/10.5858/133.11.1793.

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Abstract Adenocarcinoma and dysplasias are recognized complications of Barrett mucosa. In the past, the treatment for this carcinoma was esophagectomy. However, new techniques, including endoscopic mucosal resection, sometimes replace esophagectomy and are becoming standard procedures in clinical practice, not just in major medical centers. Pathologists must learn to handle these specimens, which have extensive artifacts. Also, Barrett mucosa has duplicated stromal layers beneath the mucosa that include a new lamina propria and a new muscularis mucosae. We must be aware of these peculiarities

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RUBIO, C. A., and R. H. RIDDELL. "Mucosal cysts in Barrett's mucosa with dysplasia." APMIS 97, no. 1-6 (1989): 297–301. http://dx.doi.org/10.1111/j.1699-0463.1989.tb00791.x.

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Maione, Francesco, Alessia Chini, Rosa Maione, et al. "Endoscopic Diagnosis and Management of Barrett’s Esophagus with Low-Grade Dysplasia." Diagnostics 12, no. 5 (2022): 1295. http://dx.doi.org/10.3390/diagnostics12051295.

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Barrett’s Esophagus is a common condition associated with chronic gastroesophageal reflux disease. It is well known that it has an association with a higher incidence of esophageal adenocarcinoma, but this neoplastic transformation is first preceded by the onset of low and high-grade dysplasia. The evaluation of low grade dysplastic esophageal mucosa is still controversial; although endoscopic surveillance is preferred, several minimally invasive endoscopic therapeutic approaches are available. Endoscopic mucosal resection and radiofrequency ablation are the most used endoscopic treatments for

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Sarigol, Samra, Robert Wyllie, Terry Gramlich, et al. "Incidence of Dysplasia in Pelvic Pouches in Pediatric Patients After Ileal Pouch‐Anal Anastomosis for Ulcerative Colitis." Journal of Pediatric Gastroenterology and Nutrition 28, no. 4 (1999): 429–34. http://dx.doi.org/10.1002/j.1536-4801.1999.tb02105.x.

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ABSTRACTBackground:The purpose of this study was to evaluate the incidence of dysplasia and the mucosal adaptation patterns of pelvic pouches in children and adolescents who had undergone ileal pouch‐anal anastomosis for ulcerative colitis.Methods:Between 1982 and 1996, 176 pediatric patients with ulcerative colitis underwent ilial pouch‐anal anastomosis. Seventy‐six patients were followed up after surgery at the Cleveland Clinic. Pouch biopsy specimens were reviewed for dysplasia and to determine mucosal adaptation patterns. Fifty‐eight of the 76 patients had an average of three mucosal biops

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Elsadek, Hany M., and Mamdouh M. Radwan. "Diagnostic Accuracy of Mucosal Biopsy versus Endoscopic Mucosal Resection in Barrett’s Esophagus and Related Superficial Lesions." International Scholarly Research Notices 2015 (January 29, 2015): 1–6. http://dx.doi.org/10.1155/2015/735807.

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Background. Endoscopic surveillance for early detection of dysplastic or neoplastic changes in patients with Barrett's esophagus (BE) depends usually on biopsy. The diagnostic and therapeutic role of endoscopic mucosal resection (EMR) in BE is rapidly growing. Objective. The aim of this study was to check the accuracy of biopsy for precise histopathologic diagnosis of dysplasia and neoplasia, compared to EMR in patients having BE and related superficial esophageal lesions. Methods. A total of 48 patients with previously diagnosed BE (36 men, 12 women, mean age 49.75±13.3 years) underwent routi

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Wayne, Sigrid, and Robert A. Robinson. "Upper Aerodigestive Tract Squamous Dysplasia: Correlation With p16, p53, pRb, and Ki-67 Expression." Archives of Pathology & Laboratory Medicine 130, no. 9 (2006): 1309–14. http://dx.doi.org/10.5858/2006-130-1309-uatsdc.

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Abstract Context.—Differential expression of cell cycle–associated proteins may correlate with human papillomavirus status and may help delineate degree of dysplasia in upper aerodigestive tract squamous lesions. Objective.—To determine intraepithelial height of immunohistochemical staining for p16, p53, pRb, and Ki-67 in upper aerodigestive tract lesions with reference to degree of dysplasia. Human papillomavirus status was ascertained to correlate with p16 expression. Design.—Biopsy specimens of 53 squamous dysplastic and 13 keratotic/hyperplastic lesions were immunohistochemically stained f

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Lahav, Yonatan, James A. Burns, Steven Feinberg, James T. Heaton, and Steven M. Zeitels. "Initial Anatomic Geographic Presentation of Glottal Dysplasia." Annals of Otology, Rhinology & Laryngology 118, no. 5 (2009): 321–25. http://dx.doi.org/10.1177/000348940911800501.

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Glottal dysplasia is likely the most common laryngeal disease with a discernible lesion; however, investigations describing its initial anatomic geographic presentation are rare. To examine this, we identified 52 patients who did not have significant prior treatment or glottal cancer. Thirty-one patients had bilateral disease, so there were 83 vocal folds with precancerous dysplasia. The phonatory mucosa was the dominant disease site in all; the epicenter was on the superior surface in 65 of the 83 folds and on the medial surface in 18 of the 83 folds. The arytenoid mucosa was involved in 8 of

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Lim, Liang, Catherine Streutker, Norman Marcon, et al. "A feasibility study of photoacoustic imaging of ex vivo endoscopic mucosal resection tissues from Barrett’s esophagus patients." Endoscopy International Open 05, no. 08 (2017): E775—E783. http://dx.doi.org/10.1055/s-0043-111790.

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Abstract Background and study aims Accurate endoscopic detection of dysplasia in patients with Barrett’s esophagus (BE) remains a major clinical challenge. The current standard is to take multiple biopsies under endoscopic image guidance, but this leaves the majority of the tissue unsampled, leading to significant risk of missing dysplasia. Furthermore, determining whether there is submucosal invasion is essential for proper staging. Hence, there is a clinical need for a rapid in vivo wide-field imaging method to identify dysplasia in BE, with the capability of imaging beyond the mucosal layer

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McCaul, James Anthony, Jeremy McMahon McMahon, Jacqueline Quantrill, et al. "LIHNCS: Lugol’s Iodine in Head and Neck Cancer Surgery—A multi-centre, randomised, controlled trial assessing the effectiveness of Lugol’s Iodine to assist excision of moderate dysplasia, severe dysplasia and carcinoma in-situ at mucosal resection margin of oral and oropharyngeal squamous cell carcinoma." Journal of Clinical Oncology 35, no. 15_suppl (2017): 6065. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.6065.

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6065 Background: Oral cavity and oropharynx cancer are increasing worldwide but survival has not significantly improved over the last thirty years. Presence of dysplasia or carcinoma in-situ at surgical margins following resection of squamous carcinoma (SCC) of the head and neck is associated with increased local recurrence and reduced survival. While carcinoma can usually be distinguished from normal mucosa, dysplasia is less readily distinguished at operation. We describe outcomes of LIHNCS, a RCT assessing effectiveness of Lugol’s iodine staining for visualization and excision of margin dys

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Thèses sur le sujet "Mucosal dysplasia"

Boustany, Nada. "Characterization of mucosal dysplasia with ultraviolet resonance Raman spectroscopy." Thesis, Massachusetts Institute of Technology, 1997. http://hdl.handle.net/1721.1/9809.

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Thesis (Ph. D.)--Harvard--Massachusetts Institute of Technology Division of Health Sciences and Technology, 1997. "August, 1997." Includes bibliographical references. by Nada Boustany. Ph.D.

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Bloor, Balvinder Kaur. "Differentiation-specific keratins in human oral mucosal disease- keratoses, lichen planus, dysplasia and carcinoma." Thesis, King's College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299445.

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Ramineni, Sandeep K. "MUCOADHESIVE FILMS FOR TREATMENT OF LOCAL ORAL DISORDERS: DEVELOPMENT, CHARACTERIZATION AND IN VIVO TESTING." UKnowledge, 2014. http://uknowledge.uky.edu/cbme_etds/19.

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Mucoadhesive drug delivery systems which are being used from 1980’s to avoid first pass metabolism of drugs, commercially exist for only systemic drug delivery with fast erosion times (15-60 min), that may not be appropriate for local oral disorders. The goal of this research was to develop and characterize mucoadhesive films with flexibility of carrying different drugs and proteins and provide sustained release for local treatment of oral disorders. Mucoadhesive films composed of polyvinylpyrrolidone (PVP) and carboxymethlycellulose (CMC) were formulated with imiquimod, an immune response mod

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Mutalik, Vimi Sunil. "Comparative Assessment of p16 Protein Expression in Normal and Dysplastic Oral Mucosal Epithelium." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1530615395569555.

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Rousseau, André. "Cyclin D1 gene amplification and protein overexpression in dysplastic oral mucosa and oral cancer." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0015/MQ53416.pdf.

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Filippas, John. "Image processing techniques for the identification of normal, dysplastic and cancerous colonic mucosa with the use of parallel processing." Thesis, Coventry University, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.420171.

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Majumdar, Debabrata. "Expression and post-translational modification of intermediate filament proteins in colonic mucosa of patients with ulcerative colitis : role in pathogenesis of colitis associated colorectal neoplasia and dysplasia." Thesis, University of Sheffield, 2016. http://etheses.whiterose.ac.uk/16564/.

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Background: Ulcerative colitis(UC) is a chronic inflammatory disease of the colon associated with increased cancer risk of colitis associated cancer(CAC). Keratins(K) are intermediate filament(IF) proteins, and are key component of the cellular cytoskeleton. K8 null mice develop colitis; a subset of IBD patients have mutation in K8 gene. Keratins play a role in cell-death signalling pathways; epithelial cells lacking K8 and K18 are more sensitive to TNF-mediated apoptosis. Methods: Colonic biopsies obtained from UC patients (and controls) were grouped into eight categories based on risk of can

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Bezerra, Ana Patricia Carneiro Gonçalves. "Análise histopatológica de lesões leucoqueratósicas da mucosa oral avaliadas pelos exames de luminescência, cromoscopia e microscopia confocal reflectante." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/23/23141/tde-19022015-111413/.

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O câncer de mucosa oral é um problema de saúde pública, com maior incidência em homens acima de 50 anos. Uma das manifestações clínicas mais precoces do câncer da mucosa oral são as lesões leucoqueratósica. O aspecto clínico não homogêneo e o tamanho maior de 200mm2, em mucosa não queratinizada como a do assoalho da boca e ventre da língua, são aspectos que implicam na possibilidade de evolução da lesão. A dificuldade do diagnóstico das lesões precoces está na seleção do local a ser biopsiado principalmente frente a lesões extensas e heterogêneas. O objetivo desta pesquisa é avaliar se a utili

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Gord?n, N??ez Manuel Antonio. "Express?o imuno-histoqu?mica das integrinas ?2?1, ?3?1, e ?5?1, em mucosa oral normal, hiperplasia fibroepitelial inflamat?ria oral e displasia epitelial oral." Universidade Federal do Rio Grande do Norte, 2006. http://repositorio.ufrn.br:8080/jspui/handle/123456789/17156.

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Made available in DSpace on 2014-12-17T15:32:31Z (GMT). No. of bitstreams: 1 ManoelAGN_tese.pdf: 5283581 bytes, checksum: 65511a1dd2487deff44e8db44d2a0cf5 (MD5) Previous issue date: 2006-08-18 Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico The objective of this study was perform by the streptoavidin-biotin technique an immunohistochemical analysis of ?2?1, ?3?1e ?5?1 integrins in 11 normal oral mucosa (NOM), 16 oral inflammatory fibroepithelial hyperplasia (OIFH) and 25 oral epithelial dysplasia (OED) (16 mild, 2 moderates and 7 severe), to determine if exists qualitat

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Zhong, Yan [Verfasser]. "Technical modifications for a one-step circumferential endoscopic mucosa resection (CEMR) to eradicate high-grade dysplasia and mucosal carcinoma in Barrett's esophagus : preliminary results / vorgelegt von Yan Zhong." 2005. http://d-nb.info/97518766X/34.

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Livres sur le sujet "Mucosal dysplasia"

Rousseau, André. Cyclin D1 gene amplification and protein overexpression in dysplastic oral mucosa and oral cancer. Faculty of Dentistry, University of Toronto], 2000.

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Chapitres de livres sur le sujet "Mucosal dysplasia"

Bos, Vincent, and Roos E. Pouw. "Is Mucosal Eradication an Effective Intervention for Barrett Esophagus with Dysplasia?" In Difficult Decisions in Surgery: An Evidence-Based Approach. Springer Nature Switzerland, 2024. https://doi.org/10.1007/978-3-031-78663-1_31.

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Watson, Thomas J., and Jeffrey H. Peters. "Esophageal Preservation in Barrett’s Esophagus with High-Grade Dysplasia and Mucosal Adenocarcinoma." In Innovation in Esophageal Surgery. Springer Milan, 2012. http://dx.doi.org/10.1007/978-88-470-2469-4_6.

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Owens, Scott R., and Henry D. Appelman. "Dysplasia and Dysplasia Mimics in Barrett’s Mucosa." In Atlas of Esophagus and Stomach Pathology. Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-8084-6_10.

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Takubo, Kaiyo, Tomio Arai, and Shingo Ishiguro. "Patient Presentation and Pathologic Diagnosis of Superficial Carcinoma of the Esophagus: High-Grade Dysplasia and Mucosal Carcinoma from the Japanese Standpoint." In Superficial Esophageal Neoplasm. Springer Japan, 2002. http://dx.doi.org/10.1007/978-4-431-67873-1_19.

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Bossi, Paolo, and Erika Stucchi. "Treatment of OPMD and First Results of Immune Checkpoint Inhibitors." In Critical Issues in Head and Neck Oncology. Springer Nature Switzerland, 2025. https://doi.org/10.1007/978-3-031-84539-0_3.

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Abstract Oral potentially malignant diseases (OPMDs) are a group of oral mucosal lesions that have a higher chance of turning into cancer. They show up in different ways, have different causes, and look differently on a microscopic level. To date, there are no clinical or histological factors that could predict the OPMDs’ malignant transformation to oral squamous cell carcinoma (OSCC), except for previous OSCC and WHO classification. Early diagnosis appears to be essential in these lesions in order to identify the risk of malignant progression and treat them accordingly. The standard treatment

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Yakin, Muhammed, and Omar Kujan. "Histopathology of the Mucosal Potentially Malignant (Dysplastic) Disorders." In Oral Histology and Oral Histopathology. Springer Nature Switzerland, 2025. https://doi.org/10.1007/978-3-031-77481-2_29.

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Ay, Deniz. "The Stomach." In Clinical Anatomy of Digestive System a Handbook for Healthcare Professionals. Nobel Tip Kitabevleri, 2024. http://dx.doi.org/10.69860/nobel.9786053358855.4.

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This chapter provides comprehensive information about the anatomical features, parts, neighborhoods, wall structure, cell types, arteries, veins, lymphatics, nerves and clinic of the stomach. The stomach has two walls, two curvatures, two holes and four sections. Wall structure; ıt consists of mucosa, submucosa, muscularis and serosa layers. In your clinic; hypertrophic pyloric stenosis, congenital gastric outlet obstruction, gastric duplication cyst, gastric volvulus, hypertrophic gastropathy, functıonal dyspepıa, gastritis, acute gastritis, chronic gastritis, eosinophilic gastritis, lymphocy

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Endo, M. "What is the incidence of dysplasia associated with the regeneration of the esophageal mucosa?" In Benign Lesions of the Esophagus and Cancer. Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-73055-9_17.

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Leoncini, Giuseppe, Simona Ronchetti, Rachele Del Sordo, and Vincenzo Villanacci. "Old and New Diagnostic Paths in Inflammatory Bowel Diseases." In Miscellaneous Considerations in Inflammatory Bowel Disease [Working Title]. IntechOpen, 2024. http://dx.doi.org/10.5772/intechopen.1004729.

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In the setting of the inflammatory bowel diseases, the role played by pathologists in the histological assessment of mucosal biopsy can be ideally divided into four steps. As a sequential proceeding, the histological evaluation has to deal with (1) the identification of the intestinal inflammation as consistent with ulcerative colitis or Crohn’s disease, distinguishing them from their own mimickers; (2) the assessment of the inflammatory activity, thus highlighting their main descriptors, also including grade and distribution; (3) the evaluation of the histological features suggesting treatmen

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Pal, Partha, Rupa Banerjee, Mohan Ramchandani, Zaheer Nabi, Duvvuru Nageshwar Reddy, and Manu Tandan. "Role of Interventional IBD in Management of Ulcerative Colitis(UC)-Associated Neoplasia and Post-Operative Pouch Complications in UC: A Systematic Review." In Ulcerative Colitis [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.106599.

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Interventional inflammatory bowel disease (IIBD) is going to play a major role in complex IBD including ulcerative-colitis associated neoplasia (UCAN) and postoperative complications after ileal pouch-anal anastomosis (IPAA) in ulcerative colitis (UC). We performed a literature search in PubMed using keywords such as “UCAN” and “endoscopic management of pouch complications,” After screening 1221 citations, finally, 91 relevant citations were identified for the systematic review. Endoscopic recognition of dysplasia should be done by high-definition white light endoscopy (HD-WLE) or dye-based/vi

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Actes de conférences sur le sujet "Mucosal dysplasia"

Marcon, Norman E. "Fluorescence Spectroscopy and Imaging for Detection of Colonic Dysplasia." In European Conference on Biomedical Optics. Optica Publishing Group, 2001. http://dx.doi.org/10.1364/ecbo.2001.4432_152.

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Cancer of the colon is the second leading cause of cancer related death in North America and Europe. Colonoscopy is currently the gold standard for the detection and removal of polyps and the diagnosis of cancer. Although a field of intense research, there are currently no surrogate serum or stool markers that accurately identify patients at risk who may have adenomatous colon polyps or curable cancer. Clinicians therefore rely on white light colonoscopy to survey colonic mucosa in their search for polyps. White light endoscopy has some limitations. It cannot detect flat, non-raised lesions. I

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Khodabandeh, Ali, Ryan Chua, Todd Preston, Samaan Rafeq, and Armin Ernst. "Idiopathic Subglottic Stenosis Complicated By Severe Subglottic Mucosal Dysplasia: Diagnosis And Management." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a2746.

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Gonzalez, JM, JP Casanova, E. Bories, S. Garcia, M. Giovannini, and M. Barthet. "IS IT REASONABLE TO PROPOSE AN ENDOSCOPIC MUCOSAL RESECTION FOR BARRET'S OESOPHAGUS WITH HIGH GRADE DYSPLASIA ON THE BIOPSIES?" In ESGE Days 2018 accepted abstracts. Georg Thieme Verlag KG, 2018. http://dx.doi.org/10.1055/s-0038-1637129.

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Uchima, H., I. Serra, L. Torrealba, et al. "ENDOSCOPIC MUCOSAL RESECTION IN DYSPLASTIC BARRETT'S OESOPHAGUS WITH UNDERLYING OESOPHAGEAL VARICES USING BAND LIGATION." In ESGE Days 2018 accepted abstracts. Georg Thieme Verlag KG, 2018. http://dx.doi.org/10.1055/s-0038-1637088.

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Overholt, Bergein F., and Masoud Panjehpour. "Barrett's esophagus: photodynamic therapy for ablation of dysplasia, reduction of specialized mucosa and treatment of superficial esophageal cancer." In Fifth International Photodynamic Association Biennial Meeting, edited by Denis A. Cortese. SPIE, 1994. http://dx.doi.org/10.1117/12.203380.

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Choi, Yoojin, Irving Salit, Sarah Grech, et al. "P154 Diffuse skewing of Th17/Treg ratio in the anorectal mucosa of HIV+MSM with HPV-associated dysplasia." In Abstracts for the STI & HIV World Congress (Joint Meeting of the 23rd ISSTDR and 20th IUSTI), July 14–17, 2019, Vancouver, Canada. BMJ Publishing Group Ltd, 2019. http://dx.doi.org/10.1136/sextrans-2019-sti.318.

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Mian, S. A., H. E. Colley, M. S. Ullah, C. Yorucu, and I. U. Rehman. "Raman Spectroscopic Analysis of Normal, Dysplastic and Cancerous Oral Mucosa: A Tissue Engineering Approach." In University of Sheffield Engineering Symposium. USES, 2015. http://dx.doi.org/10.15445/01012014.08.

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Glanzmann, Thomas M., Pascal Uehlinger, Jean-Pierre Ballini, et al. "Time-Resolved Autofluorescence Spectroscopy of the Bronchial Mucosa for the Detection of Early Cancer: Clinical Results." In European Conference on Biomedical Optics. Optica Publishing Group, 2001. http://dx.doi.org/10.1364/ecbo.2001.4432_199.

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Time-resolved measurements of endogenous tissue autofluorescence were carried out on the bronchial mucosa of 18 patients during endoscopy by the means of an optical fibre-based spectrometer. The objective was to assess the fluorescence lifetime as a new contrast parameter between normal and malignant tissue and to explain the origin of a previously observed contrast in fluorescence intensity. The intra- and interpatient variation of tissue autofluorescence intensity and decay on normal tissue was determined, with the outcome that a strong fluctuation in autofluorescence intensity but not in li

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O'Neill, C., P. Barreiro, R. Mendo, et al. "CIRCUMFERENTIAL ENDOSCOPIC SUBMUCOSAL DISSECTION FOR REFRACTORY DYSPLASTIC BARRETT’S ESOPHAGUS AFTER MUCOSAL RESECTIONS AND RADIOFREQUENCY ABLATION – A SALVAGE AND DEFINITIVE TREATMENT APPROACH?" In ESGE Days 2022. Georg Thieme Verlag KG, 2022. http://dx.doi.org/10.1055/s-0042-1744787.

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Wang, Hsing-Wen, Marcia I. Canto, Joseph Willis, Michael V. Sivak, and Joseph A. Izatt. "Quantitative Laser Scanning Confocal Autofluorescence Microscopy of Normal, Premalignant, and Malignant Colonie Tissues." In Biomedical Optical Spectroscopy and Diagnostics. Optica Publishing Group, 2006. http://dx.doi.org/10.1364/bosd.1996.ft6.

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Laser-induced fluorescence (LIF) spectroscopy has received considerable attention as an application of lasers and fiberoptics to noninvasive tissue diagnosis, particularly in early detection of cancer in the breast1, lung1,2, esophagus3, and colon4-7. LIF spectroscopy is currently under study as a noninvasive method of tissue diagnosis in the colon due to its potential for future routine application in gastrointestinal endoscopy. The distinction of normal colon from premalignant and malignant lesions is of potential clinical importance because the early detection of these lesions is important

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