Littérature scientifique sur le sujet « Multiple disease resistance »

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Articles de revues sur le sujet "Multiple disease resistance"

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Dev, V. P. S., and C. A. Mary. "Rices with Multiple Disease Resistance." International Rice Research Newsletter 10, no. 4 (1985): 4. https://doi.org/10.5281/zenodo.7099585.

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This article 'Rices with Multiple Disease Resistance' appeared in the International Rice Research Newsletter series, created by the International Rice Research Institute (IRRI). The primary objective of this publication was to expedite communication among scientists concerned with the development of improved technology for rice and for rice based cropping systems. This publication will report what scientists are doing to increase the production of rice in as much as this crop feeds the most densely populated and land scarce nations in the world.
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Drake-Stowe, Katherine, Nicolas Bakaher, Simon Goepfert, et al. "Multiple Disease Resistance Loci Affect Soilborne Disease Resistance in Tobacco (Nicotiana tabacum)." Phytopathology® 107, no. 9 (2017): 1055–61. http://dx.doi.org/10.1094/phyto-03-17-0118-r.

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Phytophthora nicotianae and Ralstonia solanacearum are two of the most important pathogens affecting tobacco worldwide. Greater insight regarding genetic systems controlling resistance to these two soilborne pathogens, as well as identification of DNA markers associated with genomic regions controlling this resistance, could aid in variety development. An evaluation of 50 historical tobacco lines revealed a high positive correlation between resistances to the two pathogens, preliminarily suggesting that some genomic regions may confer resistance to both pathogens. A quantitative trait loci (QT
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Steffenson, B. J., and K. P. Smith. "Breeding Barley for Multiple Disease Resistance in the Upper MidwestRegion of the USA." Czech Journal of Genetics and Plant Breeding 42, No. 3 (2011): 79–86. http://dx.doi.org/10.17221/3646-cjgpb.

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The Upper Midwest is one of the largest barley production areas in the USA. In this region, diseases can markedly reduce both the yield and quality of the crop. Molecular and classical breeding techniques are being employed to develop cultivars with resistance to five different diseases in the Minnesota barley improvement program. Stem rust and spot blotch have been successfully controlled for many years through the deployment of the major gene Rpg1 and a major effect QTL, respectively. A sequence characterized amplified region (SCAR) marker developed from the sequence of Rpg1 has made marker-
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Wiesner-Hanks, Tyr, and Rebecca Nelson. "Multiple Disease Resistance in Plants." Annual Review of Phytopathology 54, no. 1 (2016): 229–52. http://dx.doi.org/10.1146/annurev-phyto-080615-100037.

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Fedak, G., D. Chi, C. Hiebert, et al. "Multiple disease resistance in intergeneric hybrids." Vìsnik Lʹvìvsʹkogo nacìonalʹnogo agrarnogo unìversitetu. Agronomìâ, no. 23 (September 1, 2019): 173–76. http://dx.doi.org/10.31734/agronomy2019.01.173.

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Nene, Y. L. "Multiple-Disease Resistance in Grain Legumes." Annual Review of Phytopathology 26, no. 1 (1988): 203–17. http://dx.doi.org/10.1146/annurev.py.26.090188.001223.

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Ogbonnaya, F. C., M. Imtiaz, H. S. Bariana, et al. "Mining synthetic hexaploids for multiple disease resistance to improve bread wheat." Australian Journal of Agricultural Research 59, no. 5 (2008): 421. http://dx.doi.org/10.1071/ar07227.

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A collection of 253 synthetic hexaploid wheats (SHWs) produced from 192 Aegilops tauschii accessions and 39 elite durum varieties were studied to identify, characterise, and evaluate potentially untapped diversity of disease resistance in wheat. The diseases for which resistance was sought included cereal cyst nematode (CCN), root lesion nematode (RLN), Stagonospora nodorum blotch (SNB), Septoria tritici blotch (STB), and the 3 rusts, leaf rust, stem rust, and stripe rust, all important diseases of bread wheat worldwide, which can severely reduce wheat yield and quality. The SHWs exhibited a w
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Nadaf, S. K., I. S. Singh, and B. N. Singh. "Genetic Divergence and Multiple Disease Resistance Studies in Rice (Oryza sativa L.)." International Rice Research Newsletter 11, no. 4 (1986): 16. https://doi.org/10.5281/zenodo.7121880.

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This article 'Genetic Divergence and Multiple Disease Resistance Studies in Rice (Oryza sativa L.)' appeared in the International Rice Research Newsletter series, created by the International Rice Research Institute (IRRI). The primary objective of this publication was to expedite communication among scientists concerned with the development of improved technology for rice and for rice based cropping systems. This publication will report what scientists are doing to increase the production of rice in as much as this crop feeds the most densely populated and land scarce nations in the world.
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Morelock, T. E., J. C. Correll, and L. P. Brandenberger. "483 PB 417 BREEDING SPINACH WITH MULTIPLE DISEASE RESISTANCE." HortScience 29, no. 5 (1994): 500e—500. http://dx.doi.org/10.21273/hortsci.29.5.500e.

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Downy mildew (Blue mold) is probably the most common spinach disease in most parts of the world, and it can be a problem in the mid-South. Frequently, other diseases such as white rust and fusarium cause major crop loss. The Arkansas breeding program was initiated 25 years ago to address white rust and fusarium, as well as other diseases that destroy spinach crops. Since single gene resistance is not available for most spinach diseases, it was necessary to utilize polygenic resistance to develop varieties that are resistant to most of the common spinach diseases that occur in the Arkansas Rive
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Qiu, Yuting, Julian Cooper, Christopher Kaiser, Randall Wisser, Santiago X. Mideros, and Tiffany M. Jamann. "Identification of Loci That Confer Resistance to Bacterial and Fungal Diseases of Maize." G3: Genes|Genomes|Genetics 10, no. 8 (2020): 2819–28. http://dx.doi.org/10.1534/g3.120.401104.

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Crops are hosts to numerous plant pathogenic microorganisms. Maize has several major disease issues; thus, breeding multiple disease resistant (MDR) varieties is critical. While the genetic basis of resistance to multiple fungal pathogens has been studied in maize, less is known about the relationship between fungal and bacterial resistance. In this study, we evaluated a disease resistance introgression line (DRIL) population for the foliar disease Goss’s bacterial wilt and blight (GW) and conducted quantitative trait locus (QTL) mapping. We identified a total of ten QTL across multiple enviro
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Thèses sur le sujet "Multiple disease resistance"

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Asea, Godfrey Rox. "Genetic characterization of partial resistance and comparative strategies for improvement of host-resistance to multiple foliar pathogens of maize." Columbus, Ohio : Ohio State University, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1133833939.

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Kosaka, Ayumi. "Studies on postinvasive resistance of Arabidopsis thaliana against multiple fungal pathogens." Kyoto University, 2019. http://hdl.handle.net/2433/245323.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第22128号<br>農博第2374号<br>新制||農||1073(附属図書館)<br>学位論文||R1||N5236(農学部図書室)<br>京都大学大学院農学研究科応用生物科学専攻<br>(主査)教授 髙野 義孝, 教授 田中 千尋, 教授 寺内 良平<br>学位規則第4条第1項該当
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Van, Eeden C. (Christiaan). "The construction of gene silencing transformation vectors for the introduction of multiple-virus resistance in grapevines." Thesis, Stellenbosch : Stellenbosch University, 2004. http://hdl.handle.net/10019.1/53764.

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Thesis (MSc)--University of Stellenbosch, 2004.<br>ENGLISH ABSTRACT: Viruses are some of the most important pathogens of grapevines. There are no effective chemical treatments, and no grapevine- or other natural resistance genes have been discovered against grapevine infecting viruses. The primary method of grapevine virus control is prevention by biological indexing and molecular- and serological screening of rootstocks and scions before propagation. Due to the spread of grapevine viruses through insect vectors, and in the case of GRSPaV the absence of serological screening, these metho
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Pierson, Frank William. "The roles of multiple infectious agents in the predisposition of turkeys to colibacillosis." Diss., Virginia Tech, 1993. http://hdl.handle.net/10919/29318.

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Colibacillosis is considered one of the more costly diseases encountered in the production of market turkeys. It is responsible for a significant amount of mortality in birds between the ages of 6-12 weeks. Research conducted over the past 5 years has shown that within the Shenandoah Valley production area, multiple primary infectious agents are responsible for the predisposition of turkeys to colibacillosis. These agents were first identified as potential contributors through field case studies. They include hemorrhagic enteritis (HE) virus, Newcastle disease virus, and Bordetella avium. F
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Bassil, Fares. "Multiple system atrophy : a translational approach Characterization of the insulin/IGF-1 signaling pathway." Thesis, Bordeaux, 2015. http://www.theses.fr/2015BORD0131/document.

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Ce travail porte sur des approches translationnelles dans les synucléinopathies notamment l’atrophie multisystématisée (AMS). Au-delà de leur rôle dans la régulation du glucose, l’insulin et l’insulin like growth factor-1 (IGF-1) ont des propriétés neurotrophiques. Des études ont montrées que la signalisation de l’insuline/IGF-1 est altérée dans la maladie d'Alzheimer et des données suggèrent l’altération de l’insuline/IGF-1 dans la maladie de Parkinson (MP) et l’AMS. Nous avons mis en évidence une résistance à l’insuline dans les neurones des patients MP et AMS ainsi que dans les oligodendroc
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Baring, Michael Robert. "Selection of a multiple disease resistant runner-type peanut." Texas A&M University, 2003. http://hdl.handle.net/1969.1/5748.

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Four F2:4 populations of peanut (Arachis hypogaea L.) resulting from the complex cross Tamrun 96 X Tx901639-3 X Sun Oleic 95R were grown in three disease nurseries over a 2 year period. Three separate selection techniques were applied to determine which technique would provide the most effective method for selecting a multiple disease resistant, runner-type peanut. Technique I involved selection at a tomato spotted wilt virus nursery during the first cycle of selection and transferring the selections to a Sclerotinia minor (Jagger) nursery for a second cycle of selection in year two. Technique
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GIUDICE, GAETANO. "NEW PLANT BREEDING TECHNIQUES AND PRIMING AS A MULTIPLE LEVEL STRATEGY FOR THE CONTROL OF DOWNY MILDEW INFECTION IN GRAPEVINE." Doctoral thesis, Università degli Studi di Milano, 2022. http://hdl.handle.net/2434/924372.

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La presente tesi riguarda tre approcci complementari per un controllo più sostenibile del patogeno Plasmopara viticola: cisgenesi, RNAi e priming di difesa delle piante. Nel primo capitolo viene presentata una breve introduzione generale, toccando i principali aspetti relativi alla viticoltura in Europa, alle caratteristiche della malattia, alle nuove strategie biotecnologiche e al priming nella difesa delle piante. Nel secondo capitolo viene presentata una review che descrive in dettaglio i più recenti approcci biotecnologici per la protezione delle colture, tra cui la cisgenesi, l'editing de
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Oprica, Cristina. "Characterisation of antibiotic-resistant Propionibacterium acnes from acne vulgaris and other diseases /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-755-3/.

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Wade, Jeremy James. "The emergence and significance of multiply resistant enterococcus faecium in patients with liver disease." Thesis, King's College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265981.

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Lee, Min Jae. "THE DEVELOPMENT OF NOVEL PROTEASOME INHIBITORS FOR THE TREATMENT OF MULTIPLE MYELOMA AND ALZHEIMER’S DISEASE." UKnowledge, 2019. https://uknowledge.uky.edu/pharmacy_etds/99.

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Over a decade, proteasome inhibitors (PIs), bortezomib, carfilzomib (Cfz) and ixazomib, have contributed to a significant improvement in the overall survival for multiple myeloma (MM) patients. However, the response rate of PI was fairly low, leaving a huge gap in MM patient care. Given this, mechanistic understanding of PI resistance is crucial towards developing new therapeutic strategies for refractory/relapsed MM patients. In this dissertation work, we found H727 human bronchial carcinoid cells are inherently resistant to Cfz, yet susceptible to other PIs and inhibitors targeting upstream
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Livres sur le sujet "Multiple disease resistance"

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Hopkins, Tanne Janice, ed. Timebomb: The global epidemic of multi-drug-resistant tuberculosis. McGraw-Hill, 2002.

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Stacey, Knobler, and Institute of Medicine (U.S.). Forum on Emerging Infections., eds. The resistance phenomenon in microbes and infectious disease vectors: Implications for human health and strategies for containment : workshop summary. National Academies Press, 2003.

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Border, Peter. Diseases fighting back: The growing resistance of TB and other bacterial diseases to treatment. Parliamentary Office of Science and Technology, 1994.

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Parliamentary Office of Science and Technology. Diseases fighting back. Parliamentary Office of Science and Technology, 1994.

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File, Thomas. New insights in the treatment of severe infections in the multiple-drug resistant situation: Proceedings of a satellite symposium to the 11th International Congress on Infectious Diseases, Cancun, Mexico, March 5, 2004. Karger, 2004.

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Fontanesi, Luca, ed. The genetics and genomics of the rabbit. CABI, 2021. http://dx.doi.org/10.1079/9781780643342.0000.

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Abstract The purpose of the book is to present in one location a comprehensive overview of the progress of genetics in the rabbit, with a modern vision that integrates genomics to obtain a complete picture of the state of the art and of the applications in this species, defined according to the multiple uses and multi-faceted places that this species has in applied and fundamental biology. The 18 chapters cover several fields of genetics and genomics: Chapters 1 and 2 present the rabbit within the evolutionary framework, including the systematics, its domestication and an overview of the genet
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Gillespie, Stephen H. Management of Multiple Drug-Resistant Infections (Infectious Disease). Humana Press, 2004.

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Young, Rick. Hunting the nightmare bacteria. 2017.

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Gillespie, Stephen H. Management of Multiple Drug-resistant Infections. Humana Press Inc.,U.S., 2004.

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Gillespie, Stephen H. Management of Multiple Drug-Resistant Infections. Humana Press, 2010.

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Chapitres de livres sur le sujet "Multiple disease resistance"

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Ayliffe, Michael, Ming Luo, Justin Faris, and Evans Lagudah. "Disease Resistance." In Wheat Improvement. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-90673-3_19.

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AbstractWheat plants are infected by diverse pathogens of economic significance. They include biotrophic pathogens like mildews and rusts that require living plant cells to proliferate. By contrast necrotrophic pathogens that cause diseases such as tan spot, Septoria nodurum blotch and spot blotch require dead or dying cells to acquire nutrients. Pioneering studies in the flax plant-flax rust pathosystem led to the ‘gene-for-gene’ hypothesis which posits that a resistance gene product in the host plant recognizes a corresponding pathogen gene product, resulting in disease resistance. In contrast, necrotrophic wheat pathosystems have an ‘inverse gene-for-gene’ system whereby recognition of a necrotrophic fungal product by a dominant host gene product causes disease susceptibility, and the lack of recognition of this pathogen molecule leads to resistance. More than 300 resistance/susceptibility genes have been identified genetically in wheat and of those cloned the majority encode nucleotide binding, leucine rich repeat immune receptors. Other resistance gene types are also present in wheat, in particular adult plant resistance genes. Advances in mutational genomics and the wheat pan-genome are accelerating causative disease resistance/susceptibility gene discovery. This has enabled multiple disease resistance genes to be engineered as a transgenic gene stack for developing more durable disease resistance in wheat.
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Jamaloddin, Mohammed, Anumalla Mahender, C. Guru Gokulan, et al. "Molecular Approaches for Disease Resistance in Rice." In Rice Improvement. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-66530-2_10.

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AbstractRice production needs to be sustained in the coming decades, with changing climatic conditions becoming more conducive to the prevalence of disease outbreaks. Major rice diseases collectively cause enormous economic damage and yield instability. Breeding for disease-resistant rice varieties could be one of the best options to counter these disease outbreaks. Disease-screening protocols and newer technologies are essential for effective phenotyping and would aid in gene discovery and function. Understanding the genetics of disease mechanisms and stacking of broad-spectrum disease-resistance genes could lead to faster development of rice varieties with multiple disease resistance. New molecular breeding approaches are discussed for the development of these varieties. The molecular biology of disease resistance is now better understood and could be well manipulated for improved resilience. Transgenic approaches for disease resistance are discussed. Genome-editing tools for the development of disease-resistant rice varieties are thoroughly discussed. The use of bioinformatics tools to speed up the process and to obtain a better understanding of molecular genetics mechanisms of disease resistance is explained.
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Madhav, M. S., E. Aparna, K. M. Barbadikar, and B. N. Devanna. "Genome Editing for Multiple Disease Resistance in Crop Plants." In Advances in Plant Disease Management. CRC Press, 2023. http://dx.doi.org/10.1201/9781003403142-7.

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Gonzalez-Santamarta, Maria, Grégoire Quinet, Diana Reyes-Garau, Brigitte Sola, Gaël Roué, and Manuel S. Rodriguez. "Resistance to the Proteasome Inhibitors: Lessons from Multiple Myeloma and Mantle Cell Lymphoma." In Proteostasis and Disease. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-38266-7_6.

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Ndayihanzamaso, Privat, Sheryl Bothma, Diane Mostert, George Mahuku, and Altus Viljoen. "An Optimised Greenhouse Protocol for Screening Banana Plants for Fusarium Wilt Resistance." In Efficient Screening Techniques to Identify Mutants with TR4 Resistance in Banana. Springer Berlin Heidelberg, 2022. http://dx.doi.org/10.1007/978-3-662-64915-2_5.

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AbstractFusarium wilt, caused by the soil-borne fungus Fusarium oxysporum f. sp. cubense (Foc), is considered one of the most devastating diseases of banana in the world. Effective management of Fusarium wilt is only achieved by planting banana varieties resistant to Foc. Resistant bananas, however, require many years of breeding and field-testing under multiple geographical conditions. Field evaluation is reliable but time consuming and expensive. Small plant screening methods are, therefore, needed to speed up the evaluation of banana varieties for Foc resistance. To this end, a small plant screening method for resistance to banana Fusarium wilt is presented. The method proposes the planting of 2- to 3-month-old banana plants in soil amended with 10 g Foc-colonised millet seeds. Rhizome discoloration is then evaluated to rank the disease resistance response. The optimized millet seed technique could be useful in mass screening of newly developed genotypes for resistance to Foc.
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Dori, Annie, Rachael Farquhar, Trevor Kelebi, et al. "Partnership-Based Approach to Infectious Disease Research in Papua New Guinea." In Sustainable Development Goals Series. Springer Nature Switzerland, 2024. https://doi.org/10.1007/978-3-031-53793-6_9.

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AbstractInfectious disease research requires expertise from multiple diverse backgrounds. In Papua New Guinea (PNG), relationships are an integral part of the culture, both historically and today, and play a critical role in conducting infectious disease research activities across the country. Research efforts on vector-borne diseases (VBDs), such as malaria and dengue, run parallel to rigorous implementation research to reduce the burden of other neglected tropical diseases and combat growing anti-microbial resistance in the country. This chapter will highlight the history of collaborative research in Papua New Guinea and specifically, how the partnership-based approach to implementation research has been adopted to conduct infectious disease research at different levels of the health system. In PNG, genuine trust-based relationships have been established over time by incorporating a set of guiding principles into daily practice and focusing on principles such as authenticity, courage, equality, equity, mutual benefit, and transparency throughout the research cycle. This chapter showcases key learnings across multiple and interconnected levels of the health system. It also sheds light on nuanced approaches to partnerships which harness local knowledge and empower champions to enable meaningful research and systemic change.
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Santos, Ana Dos, Alan Thompson, Juliette Awad, Michael J. Garlepp, and Hilliard Festenstein. "DNA Polymorphism in Multiple Sclerosis, Correlations with Susceptibility and Resistance to the Disease." In Immunobiology of HLA. Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-662-39946-0_180.

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Shain, Kenneth H., and William S. Dalton. "The Bone Marrow Microenvironment: Novel Targets to Circumvent Minimal Residual Disease and Drug Resistance in Multiple Myeloma." In Advances in Biology and Therapy of Multiple Myeloma. Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-4666-8_8.

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Robdrup, Melissa, Michelle Hubbard, Linda Yuya Gorim, and Monika A. Gorzelak. "Arbuscular Mycorrhizal Fungi Under Intercrop, Regenerative, and Conventional Agriculture Systems." In Arbuscular Mycorrhizal Fungi and Higher Plants. Springer Nature Singapore, 2024. http://dx.doi.org/10.1007/978-981-99-8220-2_13.

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AbstractArbuscular mycorrhizal fungi (AMF) increase in diversity and abundance in agricultural systems that emphasize soil health practices, including regenerative agriculture and intercropping. Regenerative agriculture in principle includes any practice that increases biodiversity and living roots and integrates livestock while reducing tillage, bare soil, and agrichemical inputs. Intercropping increases biodiversity in an annual system and reduces disease prevalence and weeds while improving soil conditions and yielding more than the equivalent monocrop. These principles and practices simultaneously support AMF proliferation in soils and in turn AMF provide multiple benefits to crops. AMF colonize roots, trading photosynthates for nutrients acquired beyond the reach of the plant root system. While colonizing roots, they trigger innate plant immunity and confer resistance to some insect, fungal, and bacterial pests. Colonized plants hold more water and thus are more resistant to drought. In soils with ample AMF propagules, multiple plants are likely to become connected to their neighbors by a common mycorrhizal network (CMN). Plants connected by a CMN are likely to share beneficial microbes, resistance to disease, and resources. A better understanding of crop root traits and AMF is important to building a wholistic picture of ecological interactions that can be leveraged to maintain agricultural production in intercropped, regenerative, and conventional systems.
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Sofkova-Bobcheva, Svetla, Ivelin Pantchev, Ivan Kiryakov, et al. "Induced mutagenesis for improvement of bean (Phaseolus vulgaris L.) production in Bulgaria." In Mutation breeding, genetic diversity and crop adaptation to climate change. CABI, 2021. http://dx.doi.org/10.1079/9781789249095.0018.

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Abstract Although historically a surplus food producer, Bulgarian agriculture has faced a downturn in recent decades. Local legume cultivars have lost favour with farmers and the canning industry, due to their low productivity in comparison with imported ones. Diseases and abiotic stresses are the most important factors limiting the production of edible legumes, costing farmers hundreds of euros in lost revenue each year. The overall objective of our ongoing bean mutation breeding programme was to enrich the gene pool of Phaseolus vulgaris L. and to develop genotypes resistant to Xanthomonas axonopodis pv. phaseoli (Smith) (Xap) and Pseudomonas savastanoi pv. phaseolicola (Burkh.) (Psp) using EMS. An elite line and common cultivar (an heirloom and a snap bean type) in Bulgaria, were selected as parents and the chemical mutagen EMS was used for generating mutations. In total, 1000 seeds were treated and the two generated M1 populations were grown in the field. All M<sub>2</sub> mutant plants (1650 from initial line IP564 and 2420 from initial cultivar 'Mastilen 11b') were grown in field conditions and a number of phenotypic changes were observed on these mutated plants. They were also screened for Xap disease resistance via leaf artificial inoculation under greenhouse conditions. Individual plant selection was performed for the putatively resistant M<sub>2</sub> plants. In the M<sub>3</sub> generation these lines were screened using artificial inoculation with Xap and Psp pathogens (leaves and pods) under field conditions. Selected M<sub>3</sub>-M<sub>4</sub> lines with confirmed disease resistance were tested for fresh pod quality. Yield tests were started in M<sub>4</sub> and M<sub>5</sub> generations and, according to their productivity performance, mutants were advanced to the M<sub>6</sub>/M<sub>7</sub> generation for validation. The expression patterns of genes putatively involved in the resistance reactions towards two races of Psp were determined using qRT-PCR for the specific and reference genes. In conclusion, 50 plants with visible morphological changes and/or increased tolerance to the two targeted bacterial diseases were selected. A total of 20 advanced mutant bean lines are currently being evaluated for their competitiveness in multiple sites.
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Actes de conférences sur le sujet "Multiple disease resistance"

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Gee, A. P. "Hematopoietic Stem Cell Engineering: The Magic Bullet of the Next Millenium?" In ASME 1997 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 1997. http://dx.doi.org/10.1115/imece1997-1317.

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Abstract Hematopoietic stem cell [HSC] therapy has its origins as hematological rescue following marrow ablative high-dose therapy for refractory cancers and myelodysplastic syndromes. In its simplest form, bone marrow is collected from a tissue-matched related normal donor and intravenously infused into the patient who has usually received high-dose chemo/radiotherapy for his or her disease. The stem cells migrate to the marrow spaces, where they multiply and differentiate to restore blood cell-forming activity and immune defenses in the recipient Restrictions in the availability of tissue-ma
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N, Narwal, Choudhary R, Poras B, Ms Neha, Kapil Saini, and Ajay Sharma. "ANTIMICROBIAL PROPERTIES OF PANCHGAVYA IN CURING PLANT DISEASE." In MODERN AGRICULTURE: INNOVATIONS AND SUSTAINABILITY FOR A RESILIENT FUTURE. Anu Books, 2024. https://doi.org/10.31995/book.ab334.a25.chapter4.

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Panchgavya, the age-old organic preparation from cow-based products-milk, ghee, curd, dung and urine-has again found exciting scientific inputs in sustainable agriculture. Panchgavya, as recorded in Vedaas and Vrikshayurveda promotes ecological balance, etc., crop resistance and act as a good substitute for chemical fertilizer and pesticides. This review discusses its multiple benefits, ranging from plant growth promotion to tolerance to disease and finally yield. The efficacy of Panchgavya is tremendous in the management of plant diseases like early blight in tomato, sheath blight in rice, so
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Nelson, Emily, Omar S. Al-Odat, Sabrina M. Paparo, et al. "Efficacy of Mcl-1 Inhibitors in Multiple Myeloma Cells Resistant to Bortezomib." In 28th Annual Rowan-Virtua Research Day. Rowan University Libraries, 2024. http://dx.doi.org/10.31986/issn.2689-0690_rdw.stratford_research_day.126_2024.

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Multiple myeloma (MM) is a type of cancer that affects plasma B cells. Patients with MM often experience frequent relapses and can develop resistance to drugs. As a medical researcher, it is important to understand the role of Mcl-1 in preventing intrinsic apoptosis and drug resistance. Mcl-1 belongs to the anti-apoptotic subgroup of Bcl-2 family proteins and plays a crucial role in these processes. Mcl-1 plays a crucial role in driving disease progression and contributing to drug resistance in MM. It has been observed that there is an increased expression of Mcl-1 in 52% of patients with MM d
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Sandeepanie, W. D. Nilakshi, Samadhi Rathnayake, and Amali Gunasinghe. "Disease Identification and Mapping using CNN in Paddy Fields." In SLIIT International Conference on Advancements in Sciences and Humanities 2023. Faculty of Humanities and Sciences, SLIIT, 2023. http://dx.doi.org/10.54389/nkkj6476.

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Rice, a globally vital staple crop, sustains over half of the world’s caloric needs while supporting the livelihoods of small-scale farmers and landless laborers. The escalating global population has led to an increased demand for rice production. Sri Lanka, renowned for its premium rice quality, has a rich history of paddy cultivation. However, a substantial portion of the country’s 708,000 hectares of paddy land remains underutilized due to water scarcity and unstable terrain. The objective of this project is to enhance paddy crop quality during the critical vegetative phase by employing mac
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Song, Seung Yun, Yinan Pei, Steven R. Tippett, Dronacharya Lamichhane, Christopher M. Zallek, and Elizabeth T. Hsiao-Wecksler. "Validation of a Wearable Position, Velocity, and Resistance Meter for Assessing Spasticity and Rigidity." In 2018 Design of Medical Devices Conference. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/dmd2018-6906.

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Patients with neuromuscular disorders such as Parkinson’s disease (PD), traumatic brain or spinal cord injury, or multiple sclerosis (MS) can develop different levels of abnormal muscle behavior (hypertonia) such as rigidity and spasticity [1], [2]. Hypertonia can affect different parts of the body such as upper or lower extremities. Symptoms include pain, increased muscle tone, spasms, and decreased functional abilities. Hypertonia can interfere with many activities of daily living, greatly affecting the quality of life in patients and causing anxiety, depression, and social isolation [2].
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Mioljević, Vesna, Goran Stevanović, Biljana Damnjanović, et al. "The importance of a multidisciplinary approach in the fight against MDRO." In Proceedings of the International Congress Public Health - Achievements and Challenges. Institute of Public Health of Serbia "Dr Milan Jovanović Batut", 2024. http://dx.doi.org/10.5937/batutphco24173m.

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Introduction: The emergence of organisms resistant to multiple antibiotics (MDRO) is a major public health problem in the twenty-first century in all countries of the world. The emergence of MDRO limits the possibilities of adequate antimicrobial treatment of infections and increases morbidity, mortality and healthcare costs in healthcare institutions worldwide. Numerous studies indicate a significant association between the level of antibiotic consumption and the frequency of antibiotic resistance. According to data from the Center for Disease Control and Prevention (SDS) from 2019, 2.8 milli
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Kondratyeva, L. G., A. I. Kuzmich, I. A. Linge, D. A. Didych, and I. V. Alekseenko. "TRANSCRIPTOME ALTERATIONS IN BONE MARROW CELLS OF BCG-IMMUNIZED MICE." In X Международная конференция молодых ученых: биоинформатиков, биотехнологов, биофизиков, вирусологов и молекулярных биологов — 2023. Novosibirsk State University, 2023. http://dx.doi.org/10.25205/978-5-4437-1526-1-336.

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The effect of BCG vaccine is known to enhance resistance to another disease, and this effect is associated with the training of innate immune cells. In the framework of this work, the transcriptomes of bone marrow cells of BCG-treated mice were studied. The involvement of differentially expressed genes in multiple immune processes and signaling pathways was demonstrated.
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Krentz, Andrew J. "Cardio-Renal-Metabolic connection – Do we have possibilities for solving this problem?" In 7th International Congress of Cardionephrology KARNEF 2025. Punta Niš, 2025. https://doi.org/10.46793/karnef25.190k.

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Within the continuum of cardiometabolic diseases, a cardiovascular-kidney-metabolic (CKM) syndrome has been conceptualised. The CKM syndrome is a systemic disorder characterised by pathophysiological interactions between metabolic risk factors, chronic kidney disease (CKD), and the cardiovascular system. CKM syndrome is characterised by multiorgan dysfunction and confers a high risk of adverse cardiovascular outcomes. Relevant haemodynamic and neurohormonal pathologies of the include the metabolic syndrome (central adiposity, insulin resistance, hypertension, hyperglycaemia, atherogenic dyslip
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Peelukhana, Srikara V., Kranthi K. Kolli, Massoud Leesar, et al. "Distinguishing Epicardial and Microvascular Disease Using Combined Functional and Anatomical Endpoints in a Porcine Model." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80464.

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For a better treatment of coronary artery disease in a catheterization lab, detection of the relative contributions of the epicardial stenosis (ES) and concomitant microvascular disease (MVD) is important. To diagnose ES, fractional flow reserve (FFR), the hyperemic stenosis resistance index (hSRv) and to diagnose MVD, hyperemic microvascular resistance index (hMRv) have been tested in cath labs. However, for concurrent assessment of ES and MVD, functional parameter utilizing flow and pressure values, pressure drop coefficient (CDP) and combined functional and anatomical parameter, lesion flow
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Smolianova, N. A., N. V. Lekontceva, and A. D. Nikulin. "STUDY OF THE INTERACTION OF COLD SHOCK PROTEINS FROM MYCOBACTERIUM TUBERCULOSIS WITH SRNAS." In XI МЕЖДУНАРОДНАЯ КОНФЕРЕНЦИЯ МОЛОДЫХ УЧЕНЫХ: БИОИНФОРМАТИКОВ, БИОТЕХНОЛОГОВ, БИОФИЗИКОВ, ВИРУСОЛОГОВ, МОЛЕКУЛЯРНЫХ БИОЛОГОВ И СПЕЦИАЛИСТОВ ФУНДАМЕНТАЛЬНОЙ МЕДИЦИНЫ. IPC NSU, 2024. https://doi.org/10.25205/978-5-4437-1691-6-272.

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Tuberculosis is a common infection affecting both humans and animals. The disease is caused by various strains of Mycobacterium tuberculosis, which causes about two million deaths worldwide each year. Once infiltrated into the host, mycobacteria inhibit autophagy and intercellular signaling, they are also resistant to toxic substances, which ensures their survival within macrophages. M. tuberculosis exhibits a high degree of genetic diversity, which contributes to their resistance to drugs. The emergence of multidrug-resistant strains (MDRTB) is a serious public health problem, complicating th
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Rapports d'organisations sur le sujet "Multiple disease resistance"

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Sessa, Guido, and Gregory Martin. A functional genomics approach to dissect resistance of tomato to bacterial spot disease. United States Department of Agriculture, 2004. http://dx.doi.org/10.32747/2004.7695876.bard.

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The research problem. Bacterial spot disease in tomato is of great economic importance worldwide and it is particularly severe in warm and moist areas affecting yield and quality of tomato fruits. Causal agent of spot disease is the Gram-negative bacterium Xanthomonas campestris pv. vesicatoria (Xcv), which can be a contaminant on tomato seeds, or survive in plant debris and in association with certain weeds. Despite the economic significance of spot disease, plant protection against Xcvby cultural practices and chemical control have so far proven unsuccessful. In addition, breeding for resist
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Michel Jr., Frederick C., Harry A. J. Hoitink, Yitzhak Hadar, and Dror Minz. Microbial Communities Active in Soil-Induced Systemic Plant Disease Resistance. United States Department of Agriculture, 2005. http://dx.doi.org/10.32747/2005.7586476.bard.

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Induced Systemic Resistance (ISR) is a highly variable property that can be induced by compost amendment of potting media and soils. For example, previous studies showed that only 1 of 79 potting mixes prepared with different batches of mature composts produced from several different types of solid wastes were able to suppress the severity of bacterial leaf spot of radish caused by Xanthomonas campestris pv. armoraciae compared with disease on plants produced in a nonamended sphagnum peat mix. In this project, microbial consortia in the rhizosphere of plants grown in ISR-active compost-amended
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Lamont, Susan J., E. Dan Heller, and Avigdor Cahaner. Prediction of Immunocompetence and Resistance to Disease by Using Molecular Markers of the Major Histocompatibility Complex. United States Department of Agriculture, 1994. http://dx.doi.org/10.32747/1994.7568780.bard.

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This project utilized two live-animal populations in an integrated research program to identify molecular markers for immune response and disease resistance. The populations each had their foundation from meat-type commercial breeder chicken lines of their respective countries. Investigations effectively used unique availability of resources in each country to study commercial-type environments in Israel and line-crosses with diverse inbred lines in the US. Two bacterial systems were investigated to cover both respiratory and gastrointestinal, and primary and secondary, infections. Individual
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Mawassi, Munir, Adib Rowhani, Deborah A. Golino, Avichai Perl, and Edna Tanne. Rugose Wood Disease of Grapevine, Etiology and Virus Resistance in Transgenic Vines. United States Department of Agriculture, 2003. http://dx.doi.org/10.32747/2003.7586477.bard.

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Rugose wood is a complex disease of grapevines, which occurs in all growing areas. The disease is spread in the field by vector transmission (mealybugs). At least five elongated-phloem- limited viruses are implicated in the various rugose wood disorders. The most fully characterized of these are Grapevine virus A (GV A) and GVB, members of a newly established genus, the vitivirus. GVC, a putative vitivirus, is much less well characterized than GV A or GVB. The information regarding the role of GVC in the etiology and epidemiology of rugose wood is fragmentary and no sequence data for GVC are a
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Thomas, Claude, Yigal Cohen, James McCreight, and S. Nechama. Elucidation of the Genetic Basis of Multiple Disease Resistance in Cucumis Melo PI 124112 for Practical Application in the Development of Hybrids. United States Department of Agriculture, 1993. http://dx.doi.org/10.32747/1993.7603817.bard.

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Cahaner, Avigdor, Susan J. Lamont, E. Dan Heller, and Jossi Hillel. Molecular Genetic Dissection of Complex Immunocompetence Traits in Broilers. United States Department of Agriculture, 2003. http://dx.doi.org/10.32747/2003.7586461.bard.

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Objectives: (1) Evaluate Immunocompetence-OTL-containing Chromosomal Regions (ICRs), marked by microsatellites or candidate genes, for magnitude of direct effect and for contribution to relationships among multiple immunocompetence, disease-resistance, and growth traits, in order to estimate epistatic and pleiotropic effects and to predict the potential breeding applications of such markers. (2) Evaluate the interaction of the ICRs with genetic backgrounds from multiple sources and of multiple levels of genetic variation, in order to predict the general applicability of molecular genetic marke
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Steffenson, B. J., I. Mayrose, Gary J. Muehlbauer, and A. Sharon. ing and comparative sequence analysis of powdery mildew and leaf rust resistance gene complements in wild barley. United States-Israel Binational Agricultural Research and Development Fund, 2021. http://dx.doi.org/10.32747/2021.8134173.bard.

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Our overall, long-term goal is to exploit the genetic diversity present in cereal wild relatives for the development of cultivars with durable disease resistance. Our specific objectives for this proposal were to: 1) Utilize Association Genetics Resistance Gene Enrichment Sequencing (AgRenSeq) to identify and clone powdery mildew and leaf rust resistance gene complements in wild barley and 2) Conduct comparative sequence analyses of the cloned resistance genes to elucidate the basis of their specificity and evolution. The deployment of resistant cultivars is the most effective, economically ef
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Reisch, Bruce, Avichai Perl, Julie Kikkert, Ruth Ben-Arie, and Rachel Gollop. Use of Anti-Fungal Gene Synergisms for Improved Foliar and Fruit Disease Tolerance in Transgenic Grapes. United States Department of Agriculture, 2002. http://dx.doi.org/10.32747/2002.7575292.bard.

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Original objectives . 1. Test anti-fungal gene products for activity against Uncinula necator, Aspergillus niger, Rhizopus stolonifer and Botrytis cinerea. 2. For Agrobacterium transformation, design appropriate vectors with gene combinations. 3. Use biolistic bombardment and Agrobacterium for transformation of important cultivars. 4. Characterize gene expression in transformants, as well as level of powdery mildew and Botrytis resistance in foliage of transformed plants. Background The production of new grape cultivars by conventional breeding is a complex and time-consuming process. Transfer
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Fahima, Tzion, and Jorge Dubcovsky. Map-based cloning of the novel stripe rust resistance gene YrG303 and its use to engineer 1B chromosome with multiple beneficial traits. United States Department of Agriculture, 2013. http://dx.doi.org/10.32747/2013.7598147.bard.

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Research problem: Bread wheat (Triticumaestivum) provides approximately 20% of the calories and proteins consumed by humankind. As the world population continues to increase, it is necessary to improve wheat yields, increase grain quality, and minimize the losses produced by biotic and abiotic stresses. Stripe rust, caused by Pucciniastriiformisf. sp. tritici(Pst), is one of the most destructive diseases of wheat. The new pathogen races are more virulent and aggressive than previous ones and have produced large economic losses. A rich source for stripe-rust resistance genes (Yr) was found in w
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Shpigel, Nahum, Raul Barletta, Ilan Rosenshine, and Marcelo Chaffer. Identification and characterization of Mycobacterium paratuberculosis virulence genes expressed in vivo by negative selection. United States Department of Agriculture, 2004. http://dx.doi.org/10.32747/2004.7696510.bard.

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Mycobacterium avium subsp. paratuberculosis (MAP) is the etiological agent of a severe inflammatory bowel disease (IBD) in ruminants, known as Johne’s disease or paratuberculosis. Johne’s disease is considered to be one of the most serious diseases affecting dairy cattle both in Israel and worldwide. Heavy economic losses are incurred by dairy farmers due to the severe effect of subclinical infection on milk production, fertility, lower disease resistance and early culling. Its influence in the United States alone is staggering, causing an estimated loss of $1.5 billion to the agriculture indu
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