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Littérature scientifique sur le sujet « Natural Drug Development »

Auteur : Grafiati

Publié le 2 juin 2025

Mis à jour le 31 juillet 2025

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Articles de revues sur le sujet "Natural Drug Development"

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Lee, Gihyun. "Drug Development Using Natural Toxins." Toxins 13, no. 6 (2021): 414. http://dx.doi.org/10.3390/toxins13060414.

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Phillipson, J. D. "Natural Products and Drug Development." Trends in Pharmacological Sciences 6 (January 1985): 182–83. http://dx.doi.org/10.1016/0165-6147(85)90081-1.

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Brady, Lynn R. "Natural Products and Drug Development." Journal of Pharmaceutical Sciences 74, no. 8 (1985): 904–5. http://dx.doi.org/10.1002/jps.2600740829.

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Sardana, Satish. "Herbal drug development from natural sources." Journal of Advanced Pharmaceutical Technology & Research 3, no. 2 (2012): 82. http://dx.doi.org/10.4103/2231-4040.97274.

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Molinski, Tadeusz F., Doralyn S. Dalisay, Sarah L. Lievens, and Jonel P. Saludes. "Drug development from marine natural products." Nature Reviews Drug Discovery 8, no. 1 (2008): 69–85. http://dx.doi.org/10.1038/nrd2487.

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HC, Upadhyay. "Nature Inspired Discovery and Development of Antibacterials: An Update." Medicinal & Analytical Chemistry International Journal 8, no. 1 (2024): 1–5. http://dx.doi.org/10.23880/macij-16000193.

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The growing prevalence of pathogens resistant to several drugs poses an urgent health concern, which can only be addressed by increasing support for the research and development of newer antibiotics. Drug discovery through the exploration of nature's treasures is a successful and ongoing endeavor. However, the conventional method of discovering new drugs from natural sources has become an adjunct choice of the pharmaceutical corporations since it is time-consuming, complicated, expensive, and fraught with uncertainty. The application of several computational techniques, including combinatorial

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Alam, Fahmida, Md Asiful Islam, Mohammad Amjad Kamal, and Siew Hua Gan. "Updates on Managing Type 2 Diabetes Mellitus with Natural Products: Towards Antidiabetic Drug Development." Current Medicinal Chemistry 25, no. 39 (2019): 5395–431. http://dx.doi.org/10.2174/0929867323666160813222436.

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Over the years, natural products have shown success as antidiabetics in in vitro, in vivo studies and clinical trials. Because natural product-derived drugs are more affordable and effective with fewer side-effects compared to conventional therapies, pharmaceutical research is increasingly leaning towards the discovery of new antidiabetic drugs from natural products targeting pathways or components associated with type 2 diabetes mellitus (T2DM) pathophysiology. However, the drug discovery process is very lengthy and costly with significant challenges. Therefore, various techniques are current

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Ali, Parniya Akbar, Farah Hanif, Hosna Nettour, and Mubashar Rehman. "Strategies and Techniques of Drug Discovery from Natural Products." Global Drug Design & Development Review II, no. I (2017): 34–43. http://dx.doi.org/10.31703/gdddr.2017(ii-i).04.

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New drugs are mostly obtained from Natural sources. The traditional and ethic medicines have provided evidence on the therapeutic properties and resulted in some distinguished drug discovery of natural products. The microorganisms and the endogenous active materials from human or animal have also become a significant approach to the discovery of a drug. Bioinformatics and artificial intelligence have facilitated the study and development of products. For discovery of natural products different software have been used. Different computational software needed in the future for the predicting fea

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Dr. Amit Ghosh. "Coconut: Natural Source of Potential Anti Cancer Agent." CORD 32, no. 1 (2016): 9. http://dx.doi.org/10.37833/cord.v32i1.45.

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The current strategy of drug development is time consuming and expensive. This contrasts sharply with the vision of affordable drug development. The costly and the lengthy paradigm of drug discoveries are major obstacles for combating with rapidly emerging and sporadic diseases. The dichotomy between the urgent requirement of affordable treatment development and the hindrance it faces is apparent in several recent literatures which reflects the importance of drug repurposing and development of botanical drugs. Consistent with this idea, past few decades of studies on Cocos nucifera has yielded

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TSUKAMOTO, Sachiko. "Study on Natural Products for Drug Development." YAKUGAKU ZASSHI 130, no. 10 (2010): 1273–81. http://dx.doi.org/10.1248/yakushi.130.1273.

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Thèses sur le sujet "Natural Drug Development"

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Jurkiewicz, Crystal A. "Analysis of soy natural products and esterase enzymes for drug development." University of Toledo Health Science Campus / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=mco1307463707.

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Dinarvand, Mojdeh. "Discovery and development of novel antibacterials from natural products." Thesis, The University of Sydney, 2017. http://hdl.handle.net/2123/18569.

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Methicillin-resistant Staphylococcus aureus (MRSA) is a major human pathogen associated with a variety of moderate to severe infections. The multi-drug resistant nature of this pathogen makes treatment difficult. The main aim of this study was to screen a library of marine samples for novel compounds with antibacterial activity. A high-throughput assay was developed to identify active extracts, followed by determination of minimum inhibitory concentrations (MICs) for hits. The toxicity of marine samples was measured against different cells lines. Crude extracts were purified using column chrom

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Hatherley, Rowan. "Structural bioinformatics studies and tool development related to drug discovery." Thesis, Rhodes University, 2016. http://hdl.handle.net/10962/d1020021.

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This thesis is divided into two distinct sections which can be combined under the broad umbrella of structural bioinformatics studies related to drug discovery. The first section involves the establishment of an online South African natural products database. Natural products (NPs) are chemical entities synthesised in nature and are unrivalled in their structural complexity, chemical diversity, and biological specificity, which has long made them crucial to the drug discovery process. South Africa is rich in both plant and marine biodiversity and a great deal of research has gone into isolatin

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Johnston, Heather Jennifer. "Development of novel analogues of the anti-proliferative marine natural product bisebromoamide : synthesis and structure activity relationship studies." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/17617.

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The linear peptide bisebromoamide was isolated by the Suenaga group in 2009 from the marine cyanobacterium Lyngbya sp. It exhibits antiproliferative activity at nanomolar levels against a wide range of cell lines. Current SAR data indicates that there is some flexibility in the structure with respect to stereochemistry, but the range of modifications that have been biologically tested is limited, as reviewed in Chapter 1. Bisebromoamide contains a number of non-commercial amino acids and an oxopropyl pyrrolidine moiety which had not been found in a natural product previously. Several new synth

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Cockroft, Nicholas T. "Applications of Cheminformatics for the Analysis of Proteolysis Targeting Chimeras and the Development of Natural Product Computational Target Fishing Models." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu156596730476322.

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Oliva, Francisco. "The Anti-cancer Properties of Podophyllotoxin Analogues." Youngstown State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1579197212456721.

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Menzies, Stefanie Kate. "Investigating the trypanocidal activity of simplified natural product-like analogs and the characterization of a novel trypanosomatid-specific secondary alternative oxidase." Thesis, University of St Andrews, 2017. http://hdl.handle.net/10023/12041.

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This thesis aimed to identify the trypanocidal mode of action of non-natural chamuvarinin analogs, and to assess the previously uncharacterized secondary alternative oxidase (AOX2) as a possible drug target of the trypanosomatids. The drugs used to treat infections with Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp. are highly toxic and are increasingly becoming less effective as the parasites develop resistance, therefore new drugs against the diseases are desperately needed. Non-natural analogs of chamuvarinin were tested for trypanocidal activity to determine the structure activi

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Gabriele, E. "SYNTHESIS OF NEW SULFURATED DERIVATIVES OF NATURAL AND SYNTHETIC SYSTEMS AS MULTITARGET ANTICANCER AGENTS AND DEVELOPMENT OF NEW DRUG DISCOVERY METHODOLOGIES." Doctoral thesis, Università degli Studi di Milano, 2017. http://hdl.handle.net/2434/473431.

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This PhD thesis is divided in two parts. The former, entitled "Design and synthesis of new derivatives of natural and synthetic systems endowed with anticancer activity, through a multitarget mechanism", has been carried out at the Universitá degli Studi di Milano under the supervision of Professor Anna Sparatore. This project treats the synthesis of new sulfurated compounds with the aim of obtaining anticancer agents acting through a multitarget mechanism. On one hand, we explored the potentialities of new sulfurated chemical scaffolds, such as dithiolethiones, methanethiosulfonates and allyl

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Lock, de Ugaz Olga. "Bioassay methods in natural product research and drug development. Lars Bohlin and Jan G. Bruhn Ed. Kluwer Academic Publishers, The Netherlands, 1999,201 p." Revista de Química, 2013. http://repositorio.pucp.edu.pe/index/handle/123456789/100706.

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Martínez, Pérez Carlos. "Evaluation of the antitumour activity of novel flavonoids on pre-clinical models of breast and ovarian cancer." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/25410.

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New drugs are needed for better cancer management. Clinical trials are currently underway to assess the use of flavonoids (natural polyphenols) as anticancer agents. Among them, myricetin has been shown to induce cell cycle arrest and apoptosis in pre-clinical cancer models. We hypothesised that myricetin-derived novel flavonoids designed to enhance this natural potential and improve on the drug-likeness limitations of myricetin might have increased potential for their application in the management of breast and ovarian cancer. The effect of a library of novel flavonoids was screened on 3 pane

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Livres sur le sujet "Natural Drug Development"

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Gurib-Fakim, Ameenah. Biodiversity towards drug development. University of Mauritius Press, 2005.

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Bohlin, Lars, and Jan G. Bruhn, eds. Bioassay Methods in Natural Product Research and Drug Development. Springer Netherlands, 1999. http://dx.doi.org/10.1007/978-94-011-4810-8.

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Lars, Bohlin, and Bruhn J. G, eds. Bioassay methods in natural product research and drug development. Kluwer Academic, 1999.

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Valeriote, Frederick A., Thomas H. Corbett, and Laurence H. Baker, eds. Anticancer Drug Discovery and Development: Natural Products and New Molecular Models. Springer US, 1994. http://dx.doi.org/10.1007/978-1-4615-2610-0.

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Sharma, Tripti, Chita Ranjan Sahoo, Debdutta Bhattacharya, and Sanghamitra Pati, eds. Natural Products for Antibacterial Drug Development: Recent Advancement of Computational Approach. Springer Nature Singapore, 2024. https://doi.org/10.1007/978-981-97-9634-2.

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A, Valeriote Frederick, Corbett Thomas H, and Baker Lawrence H, eds. Anticancer drug discovery and development: Natural products and new molecular models : proceedings of the Second Drug Discovery and Development Symposium, Traverse City, Michigan, USA, June 27-29, 1991. Kluwer Academic Publishers, 1994.

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Tekle-Smith, Makeda Aislinn. Synthetic Innovations Towards the Total Synthesis of Natural Product Derivatives for Drug Development. [publisher not identified], 2019.

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Feng, Wang, ed. Biomarker methods in drug discovery and development. Humana Press, 2008.

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Bainbridge, David. Teenagers: A natural history. Portbello Books, 2010.

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P, Devlin John, ed. High throughput screening: The discovery of bioactive substances. M. Dekker, 1997.

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Chapitres de livres sur le sujet "Natural Drug Development"

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McKee, Tawnya C., Albert W. W. Van Wyk, and Emily L. Whitson. "Natural Product Screening." In Cancer Drug Discovery and Development. Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-9135-4_3.

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Singh, Inder Pal, Furkan Ahmad, Debanjan Chatterjee, Ruchi Bajpai, and Neha Sengar. "Natural Products: Drug Discovery and Development." In Drug Discovery and Development. Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-5534-3_2.

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Verma, Garima, Mohammad Shaquiquzzaman, and Mohammad Mumtaz Alam. "Heterocyclic Drug Design and Development." In Promising Drug Molecules of Natural Origin. Apple Academic Press, 2020. http://dx.doi.org/10.1201/9781003010395-12.

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Hesterlee, Sharon. "Optimizing Rare Disease Registries and Natural History Studies." In Rare Disease Drug Development. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-78605-2_8.

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Cragg, Gordon M., Michael R. Boyd, Rita Khanna, David J. Newman, and Edward A. Sausville. "Natural Product Drug Discovery and Development." In Phytochemicals in Human Health Protection, Nutrition, and Plant Defense. Springer US, 1999. http://dx.doi.org/10.1007/978-1-4615-4689-4_1.

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Mishra, Bhuwan B., Navneet Kishore, Rakesh K. Singh, and Vinod Kumar Tiwari. "Scope of Alkaloids in Antileishmanial Drug Discovery and Development." In Natural Products. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-22144-6_91.

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Mishra, Tripti, Vinod K. Tiwari, and Bhuwan B. Mishra. "Scope of Alkaloids in Antileishmanial Drug Discovery and Development." In Natural Products. Springer Berlin Heidelberg, 2025. https://doi.org/10.1007/978-3-642-36202-6_91-1.

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Jasmine, Jublee, and Saswat S. Mohapatra. "Antibiotic Drug Development Methods." In Natural Products for Antibacterial Drug Development: Recent Advancement of Computational Approach. Springer Nature Singapore, 2024. https://doi.org/10.1007/978-981-97-9634-2_12.

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Bhardwaj, Priyanka, Ayesha Aiman, Faiza Iram, et al. "Natural Compound Toxicity: An Egregiously Overlooked Topic." In Advances in Antifungal Drug Development. Springer Nature Singapore, 2024. http://dx.doi.org/10.1007/978-981-97-5165-5_25.

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Jaiswal, Neha, and Awanish Kumar. "Harnessing the Antifungal Potential of Natural Products." In Advances in Antifungal Drug Development. Springer Nature Singapore, 2024. http://dx.doi.org/10.1007/978-981-97-5165-5_8.

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Actes de conférences sur le sujet "Natural Drug Development"

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Otte, Lennart B., Christer Hogstrand, Adil Mardinoglu, and Miao Guo. "Multi-Omics biological embeddings for ML-models." In The 35th European Symposium on Computer Aided Process Engineering. PSE Press, 2025. https://doi.org/10.69997/sct.136974.

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Machine learning algorithms have led to the development of numerous vector embeddings for biological entities such as metabolites, proteins, genes, and enzymes. However, these embeddings often lack contextual information due to their specialized focus on individual omics. Disease progression and biosynthesis pathways are increasingly understood through complex, multi-layered networks that integrate diverse omics data and intricate signaling and reaction sequences. Capturing these relationships in a meaningful way requires embeddings that account for both functional and multi-modal dependencies

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Obeyesekere, Nihal, and Thusitha Wickramarachchi. "Transition from Combinatorial Chemistry to Present Day Robotics in Product Development for Oil Field Chemicals." In MECC 2023. AMPP, 2023. https://doi.org/10.5006/mecc2023-20245.

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Abstract In this paper, the slow evolution of combinatorial chemistry from its dawn in 1980’s to today’s oil field product development is discussed. Combinatorial chemistry comprises chemical synthetic methods that make it possible to prepare a vast number of compounds in a single process. These compound libraries can be made as mixtures, sets of individual compounds or chemical structures generated by computer software. This phenomenon was first invented by Arpad Furka (Lorand University, Budapest) in 1982. He described the principle of it, the combinatorial synthesis and a deconvolution proc

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Nalepa, Christopher J. "25 Years of Bromine Chemistry in Industrial Water Systems: A Review." In CORROSION 2004. NACE International, 2004. https://doi.org/10.5006/c2004-04087.

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Abstract Bromine chemistry is used to great advantage in nature for fouling control by a number of sessile marine organisms such as sponges, seaweeds, and bryozoans. Such organisms produce small quantities of brominated organic compounds that effectively help keep their surfaces clean of problem bacteria, fungi, and algae. For over two decades, bromine chemistry has been used to similar advantage in the treatment of industrial water systems. The past several years in particular has seen the development of several diverse bromine product forms – one-drum stabilized bromine liquids, all-bromine

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Zaidi, Syed Rehan, and Husin Sitepu. "Characterization of Corrosion Products in Oil and Gas Facilities Using X-ray Powder Diffraction Method." In CORROSION 2011. NACE International, 2011. https://doi.org/10.5006/c2011-11393.

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Abstract The failures of boiler tubes have consistently occurred in the Refinery (Ras Tanura, Jiddah and Riyadh) and gas plants (Ju’aymah and Shedgum). The Research and Development Center (R&DC) has helped the plant engineers to overcome the problems by identifying the nature and source of compounds (e.g., corrosion products, formation materials and scale deposits). The boiler consists of a furnace, boiler tubes, steam drum, mud drum and boiler. The furnace usually provides heat to the boiler and then changes water into steam. Here are the problems on why boiler tubes failed. The presence

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Li, Kun, Xiuwen Gong, Jia Wu, and Wenbin Hu. "Contrastive Learning Drug Response Models from Natural Language Supervision." In Thirty-Third International Joint Conference on Artificial Intelligence {IJCAI-24}. International Joint Conferences on Artificial Intelligence Organization, 2024. http://dx.doi.org/10.24963/ijcai.2024/235.

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Deep learning-based drug response prediction (DRP) methods can accelerate the drug discovery process and reduce research and development costs. Despite their high accuracy, generating regression-aware representations remains challenging for mainstream approaches. For instance, the representations are often disordered, aggregated, and overlapping, and they fail to characterize distinct samples effectively. This results in poor representation during the DRP task, diminishing generalizability and potentially leading to substantial costs during the drug discovery. In this paper, we propose CLDR, a

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Marshall, Lauren, Isabel Löwstedt, Paul Gatenholm, and Joel Berry. "Prevascularized, Co-Culture Model for Breast Cancer Drug Development." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80409.

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The objective of this study was to create 3D engineered tissue models to accelerate identification of safe and efficacious breast cancer drug therapies. It is expected that this platform will dramatically reduce the time and costs associated with development and regulatory approval of anti-cancer therapies, currently a multi-billion dollar endeavor [1]. Existing two-dimensional (2D) in vitro and in vivo animal studies required for identification of effective cancer therapies account for much of the high costs of anti-cancer medications and health insurance premiums borne by patients, many of w

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Kokunešoski, Maja, and Jovana Ružić. "FILTERS DEVELOPMENT FOR THE PURIFICATION OF INDUSTRIAL WATER OF CLAY MINERALS." In 8th Workshop Food and Drug Safety and Qualit. Vinča Institute of Nuclear Sciences - National Institute of the Republic of Serbia, 2024. http://dx.doi.org/10.46793/8fdsq.pa6mk.

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In this study, clay from the Kolubara mine in Serbia was used to make filters as a separation media. This study, as a consequence, explores the scientific area of developing porous materials from natural minerals and areas of environmental protection. After clay purification, H3BO3 contents of 2 wt.% and 0.5 wt.% were used as a low-cost, environmentally friendly chemical to create a porous structure. The influence of different amounts of H3BO3 on the separation ability of the clay filter was monitored. Additionally, various synthesis conditions, such as low pressing pressure of up to 60 MPa an

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Nabatanzi, Alice. "The Future of Africa’s Natural Products in Drug Discovery and Development: Trends and Challenges." In GA – 69th Annual Meeting 2021, Virtual conference. Georg Thieme Verlag, 2021. http://dx.doi.org/10.1055/s-0041-1736749.

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Komathi, S., and T. R. Heera. "In silico pharmacokinetics (ADMET) properties of selective natural flavonoid compounds - A prospect for the development of novel antioxidant drug." In INTERNATIONAL CONFERENCE ON MINERALS, MATERIALS AND MANUFACTURING METHODS (ICMMMM). AIP Publishing, 2023. http://dx.doi.org/10.1063/5.0159089.

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Verdes, Anastasia, Elena Gorincioi, Lucian Lupascu, Gheorghe Duca, and Fliur Macaev. "Targeting the bioactive dihydropyrimidines by ecofriendly procedure of biginelli reaction: study case of monastrol." In Scientific seminar with international participation "New frontiers in natural product chemistry". Institute of Chemistry, Republic of Moldova, 2023. http://dx.doi.org/10.19261/nfnpc.2023.ab24.

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Biologically active compounds decorated with dihydropyridine moiety are counted amongst the numerous broad-spectrum therapeutic agents that explain the increasing role of this scaffold in rational drug design [1]. The Biginelli reaction is a multicomponent reaction of aldehyde, (thio)urea, and ß-ketoester, involving Mannich reaction in the first step, which produces multifunctionalized 3,4-dihydropyrimidin-2-(1H)-ones and related heterocyclic compounds [2]. The attractiveness of this acid-catalyzed one-pot condensation reaction lies in the simplicity of grafting the substituent into the struct

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Rapports d'organisations sur le sujet "Natural Drug Development"

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Zhang, Cheng, and Yue Yang. Impact of adaptive design on reducing the duration of clinical trials in rare cancers: a meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.2.0081.

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Review question / Objective: Whether the application of adaptive design in clinical trials of rare cancers can shorten the duration of clinical trials? Condition being studied: Currently, the development of innovative drug products (InMPs) for rare cancers faces many challenges, including the difficulty of enrolling sufficient numbers of patients from small and heterogeneous patient populations for clinical trials, and the significant risks of high financial investment, long development times and potential failure from a pharmaceutical company's perspective for rare cancer drugs due to limited

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Vignoles, Christopher, and Anneke Jessen. CARICOM Report No. 2 (2005). Inter-American Development Bank, 2005. http://dx.doi.org/10.18235/0008587.

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Economic growth in the Caribbean Community (CARICOM) has been slow in the last two decades, averaging just 1.8 percent a year, compared to annual growth of 3.5 percent in the world economy and 4.3 percent in developing countries. Growth has varied considerably among CARICOM¿s 15 member states, but in most countries it has slowed over the years. The Organization of Eastern Caribbean States (OECS), for example, witnessed above-average growth of 5.4 percent a year in the period 1984-1994, but only 3.3 percent in 1994-1999, and only 1.2 percent in 1999-2004. Of the remaining CARICOM countries, onl

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Wang, Hao, and Yulai Xu. Chemopreventive Effects of Immunotrophic Preparations in the Development of Prostate Cancer: A Network Meta-Analysis of Randomized Controlled Trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.8.0037.

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Review question / Objective: After successful treatment with ADT, most patients with advanced disease eventually develop resistance and progress to castration-resistant PCa (CRPC), which remains an incurable disease.Low survival and high mortality of PCa are associated with the appearance of CRPC and subsequent metastatic disease. To advance the fight against PCa, it is necessary to continue basic and clinical research to improve testing, prevention and treatment practices. However, under current treatments, prevention should be seen as a basic strategy to reduce PCa morbidity and mortality. E

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Cytryn, Eddie, Mark R. Liles, and Omer Frenkel. Mining multidrug-resistant desert soil bacteria for biocontrol activity and biologically-active compounds. United States Department of Agriculture, 2014. http://dx.doi.org/10.32747/2014.7598174.bard.

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Control of agro-associated pathogens is becoming increasingly difficult due to increased resistance and mounting restrictions on chemical pesticides and antibiotics. Likewise, in veterinary and human environments, there is increasing resistance of pathogens to currently available antibiotics requiring discovery of novel antibiotic compounds. These drawbacks necessitate discovery and application of microorganisms that can be used as biocontrol agents (BCAs) and the isolation of novel biologically-active compounds. This highly-synergistic one year project implemented an innovative pipeline aimed

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Evidence Synthesis and Meta-Analysis for Drug Safety. Council for International Organizations of Medical Sciences (CIOMS), 2016. http://dx.doi.org/10.56759/lela7055.

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At any point in the drug development process, systematic reviews and meta-analysis can provide important information to guide the future path of the development programme and any actions that might be needed in the post-marketing setting. This report gives the rationale for why and when a meta-analysis should be considered, all in the context of regulatory decision-making, and the tasks, data collection, and analyses that need to be carried out to inform those decisions. -- There is increasing demand by decision-makers in health care, the biopharmaceutical industry, and society at large to hav

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