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Articles de revues sur le sujet « NFE2 »

Auteur : Grafiati

Publié le 9 mars 2023

Mis à jour le 31 juillet 2025

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1

García-Rodríguez, Fernando M., and Nicolás Toro. "Sinorhizobium meliloti nfe (Nodulation Formation Efficiency) Genes Exhibit Temporal and Spatial Expression Patterns Similar to Those of Genes Involved in Symbiotic Nitrogen Fixation." Molecular Plant-Microbe Interactions® 13, no. 6 (2000): 583–91. http://dx.doi.org/10.1094/mpmi.2000.13.6.583.

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The nfe genes (nfeA, nfeB, and nfeD) are involved in the nodulation efficiency and competitiveness of the Sinorhizobium meliloti strain GR4 on alfalfa roots. The nfeA and nfeB genes are preceded by functional nif consensus sequences and NifA binding motifs. Here, we determined the temporal and spatial expression patterns of the nfe genes in symbiosis with alfalfa. Translational fusions of the nfe promoters with the gusA gene and reverse transcription-polymerase chain reaction analyses indicate that they are expressed and translated within mature nitrogen-fixing nodules and not during early ste

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Sanders, Mathijs A., Annelieke Zeilemakers, Jasper Koenders, et al. "The Gene Encoding Nuclear Erythroid Factor 2 (NFE2) Is Recurrently Mutated in Acute Myeloid Leukemia." Blood 120, no. 21 (2012): 1392. http://dx.doi.org/10.1182/blood.v120.21.1392.1392.

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Abstract Abstract 1392 Background: Acute myeloid leukemia (AML) is a heterogeneous disease characterized by the accumulation of various acquired (cyto)genetic aberrations in the leukemic blasts. Novel state-of-the-art sequencing technologies enable sequencing of complete disease genomes. Methods: We have used Complete Genomics (CG) next-generation sequencing to identify novel recurrent mutations in AML. We have selected a single AML case, WHO: AML with maturation, FAB: M2, karyotype 45X, -Y and a NPM1 mutation. Mutations in FLT3, CEBPA, ASXL1, IDH1, IDH2, NRAS, KRAS and DNMT3A were absent. By

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Peeken, Jan C., Jonas S. Jutzi, Julius Wehrle, et al. "Epigenetic regulation of NFE2 overexpression in myeloproliferative neoplasms." Blood 131, no. 18 (2018): 2065–73. http://dx.doi.org/10.1182/blood-2017-10-810622.

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Key Points Overexpression of NFE2 in MPNs is associated with H3Y41 phosphorylation by JAK2V617F. JMJD1C is an NFE2 target gene and acts in a positive feedback loop contributing to NFE2 overexpression in MPNs.

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Steiner, Laurie A., Vincent P. Schulz, Yelena Maksimova, Milind Mahajan, David M. Bodine, and Patrick G. Gallagher. "Dynamic CO-Localization of GATA1, NFE2, and EKLF and Changes in Gene Expression During Hematopoiesis." Blood 116, no. 21 (2010): 741. http://dx.doi.org/10.1182/blood.v116.21.741.741.

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Abstract Abstract 741 Regulation of lineage choice during the development and differentiation of erythroid cells in hematopoiesis is a complex process. GATA1, NFE2, and EKLF are transcription factors critical for erythropoiesis. Focused studies, including detailed analyses of the human beta globin gene locus and a select group of erythrocyte membrane protein genes, have revealed that these three transcription factors may co-localize at common regulatory sites in erythroid-expressed genes. To address the hypothesis that GATA1, NFE2, and EKLF frequently co-localize on critical regulatory element

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Rost, Megan S., Ilya Shestopalov, Yang Liu, et al. "Nfe2 is dispensable for early but required for adult thrombocyte formation and function in zebrafish." Blood Advances 2, no. 23 (2018): 3418–27. http://dx.doi.org/10.1182/bloodadvances.2018021865.

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AbstractThe NFE2 transcription factor is expressed in multiple hematopoietic lineages with a well-defined role in regulating megakaryocyte biogenesis and platelet production in mammals. Mice deficient in NFE2 develop severe thrombocytopenia with lethality resulting from neonatal hemorrhage. Recent data in mammals reveal potential differences in embryonic and adult thrombopoiesis. Multiple studies in zebrafish have revealed mechanistic insights into hematopoiesis, although thrombopoiesis has been less studied. Rather than platelets, zebrafish possess thrombocytes, which are nucleated cells with

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Rost, Megan S., Ilya Shestopalov, Yang Liu, et al. "Nfe2 Is Dispensable for Early, but Required for Adult Thrombocyte Formation and Function in Zebrafish." Blood 128, no. 22 (2016): 2534. http://dx.doi.org/10.1182/blood.v128.22.2534.2534.

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Abstract The NFE2 transcription factor is expressed in multiple hematopoietic lineages with a well-defined role in regulating megakaryocyte biogenesis and platelet production in mammals. Mice deficient in NFE2 completely lack circulating platelets, causing early lethality due to neonatal hemorrhage. Recent data in mice suggest some differences in embryonic and adult thrombopoiesis, and overexpression of NFE2 in murine bone marrow cells increases megakaryocyte maturation and platelet release, suggesting a role for NFE2 in both early and late megakaryocyte development. Zebrafish have emerged as

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Li, You-Jun, Rachel R. Higgins, Brian J. Pak, et al. "p45NFE2 Is a Negative Regulator of Erythroid Proliferation Which Contributes to the Progression of Friend Virus-Induced Erythroleukemias." Molecular and Cellular Biology 21, no. 1 (2001): 73–80. http://dx.doi.org/10.1128/mcb.21.1.73-80.2001.

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ABSTRACT In previous studies, we identified a common site of retroviral integration designated Fli-2 in Friend murine leukemia virus (F-MuLV)-induced erythroleukemia cell lines. Insertion of F-MuLV at the Fli-2 locus, which was associated with the loss of the second allele, resulted in the inactivation of the erythroid cell- and megakaryocyte-specific genep45 NFE2 . Frequent disruption ofp45 NFE2 due to proviral insertion suggests a role for this transcription factor in the progression of Friend virus-induced erythroleukemias. To assess this possibility, erythroleukemia was induced by F-MuLV i

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Dou, Rui, Xiong Wang, and Jin Zhang. "Prognostic Value and Immune Infiltration Analysis of Nuclear Factor Erythroid-2 Family Members in Ovarian Cancer." BioMed Research International 2022 (January 11, 2022): 1–9. http://dx.doi.org/10.1155/2022/8672258.

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Ovarian cancer (OC) often presents at an advanced stage and is still one of the most frequent causes of gynecological cancer-related mortality worldwide. The nuclear factor erythroid-2 (NFE2) transcription factors include nuclear factor, erythroid 2 like 1 (NFE2L1), NFE2L2, and NFE2L3. NFE2 members bind to the antioxidant-response element (ARE) region and activate the expression of targeted genes. The distinct functions of NFE2 members in OC remain poorly elucidated. Several online bioinformatics databases were applied to determine gene expression, prognosis, mutations, and immune infiltration

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Pratt, Stephen J., Anna Drejer, Helen Foott, et al. "Isolation and characterization of zebrafish NFE2." Physiological Genomics 11, no. 2 (2002): 91–98. http://dx.doi.org/10.1152/physiolgenomics.00112.2001.

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Vertebrate hematopoiesis is regulated by distinct cell-specific transcription factors such as GATA-1 and SCL. Mammalian p45-NFE2 was characterized for its ability to bind the hypersensitive sites of the globin locus control region. NFE2 is a member of a cap’n’collar (CNC) and basic zipper (BZIP) superfamily that regulates gene transcription. It has been implicated in diverse processes such as globin gene expression, oxidative stress, and platelet lineage differentiation. Here, we have isolated the zebrafish ortholog of NFE2. The gene is highly homologous, particularly in the DNA-binding domain

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Heuston, Elisabeth F., Jens Lichtenberg, Stacie M. Anderson, et al. "Differences In The Genome-Wide Epigenetic Signatures Of mRNA and Long Non-Coding RNA Genes In Mouse Erythroblasts and Megakaryocytes." Blood 122, no. 21 (2013): 1198. http://dx.doi.org/10.1182/blood.v122.21.1198.1198.

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Abstract The ENCODE project has demonstrated that epigenetic signatures, including DNA methylation and transcription factor (TF) occupancy, define gene expression. However, ENCODE was constructed using static cells that were not capable of further differentiation. We hypothesize that specific epigenetic profiles are associated with erythroid and megakaryocytic differentiation. To test this hypothesis, we isolated primary erythroblasts (EBs) and megakaryocytes (Megs) from mouse bone marrow by flow cytometry and prepared: 1) DNA for genome-wide methylation analysis using MBD2 Methyl-Seq; 2) RNA

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Lee, Taunia D., Heping Yang, Janet Whang, and Shelly C. Lu. "Cloning and characterization of the human glutathione synthetase 5′-flanking region." Biochemical Journal 390, no. 2 (2005): 521–28. http://dx.doi.org/10.1042/bj20050439.

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GSH synthesis occurs through a two-step enzymatic reaction driven by GCL (glutamate–cysteine ligase; made up of catalytic and modifying subunits) and GSS (glutathione synthetase). In humans, oxidative stress regulates GCL expression in an antioxidant response element-dependent manner via Nrf2 [NFE (nuclear factor erythroid)-related factor 2]. In the rat, GSS and GCL are regulated co-ordinately by oxidative stress, and induction of GSS further increases GSH synthetic capacity. Transcriptional regulation of the human GSS has not been examined. To address this, we have cloned and characterized a

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Obazelu, PA, and CO Gaius-Igboanugwo. "Effect of a bi-herbal formula extract on ETS Variant-6 and Nuclear Factor Erythroid-2 Genes expression in Phenyl-Hydrazine induced anaemia in Albino Wistar rats." Journal of Medicine and Biomedical Research 23, no. 1 (2024): 45–52. http://dx.doi.org/10.4314/jmbr.v23i1.8.

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Background: Alterations in the expressions of ETS variant-6 (ETV6) and Nuclear Factor Erythroid 2 (NFE2) may occur as part of cellular response to phenyl-hydrazine administration and the need to replenish RBCs. Understanding the relationship between phenyl-hydrazine-induced damage, erythropoiesis, and transcriptional regulation mediated by ETV6 and NFE2 provides valuable insights into the mechanisms underlying anaemia. Therefore, this study aimed to determine the effect of bi-herbal formula of Picralima nitida and Cymbopogon citratus aqueous leaf extracts on ETV6 and NFE2 gene expressions in p

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Boas, Stephanie M., Kathlene L. Joyce, and Rita M. Cowell. "The NRF2-Dependent Transcriptional Regulation of Antioxidant Defense Pathways: Relevance for Cell Type-Specific Vulnerability to Neurodegeneration and Therapeutic Intervention." Antioxidants 11, no. 1 (2021): 8. http://dx.doi.org/10.3390/antiox11010008.

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Oxidative stress has been implicated in the etiology and pathobiology of various neurodegenerative diseases. At baseline, the cells of the nervous system have the capability to regulate the genes for antioxidant defenses by engaging nuclear factor erythroid 2 (NFE2/NRF)-dependent transcriptional mechanisms, and a number of strategies have been proposed to activate these pathways to promote neuroprotection. Here, we briefly review the biology of the transcription factors of the NFE2/NRF family in the brain and provide evidence for the differential cellular localization of NFE2/NRF family member

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Marcault, Clemence, Lin-Pierre Zhao, Rafael Daltro De Oliveira, et al. "NFE2 Mutations Impact AML Transformation and Overall Survival in Patients with Myeloproliferative Neoplasms (MPN)." Blood 136, Supplement 1 (2020): 36. http://dx.doi.org/10.1182/blood-2020-136177.

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Introduction: MPN are a heterogeneous group of chronic hematological malignancies often resulting from a combination of a driver gene mutation (JAK2, MPL or CALR) and a variety of somatic mutations harboring diverse prognosis values. A subset of MPN patients carry somatic mutations in the hematopoietic transcription factor NFE2 (nuclear factor erythroid 2) resulting in a functionally enhanced truncated form of NFE2 (Jutzi JS et al., JEM, 2013). Moreover, epigenetically induced overexpression of NFE2 has recently been reported in the majority of MPN patients (Peeken JC et al., Blood, 2018). In

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Zhang, Di, Sadahiro Iwabuchi, Tomohisa Baba, Shin-ichi Hashimoto, Naofumi Mukaida, and So-ichiro Sasaki. "Involvement of a Transcription factor, Nfe2, in Breast Cancer Metastasis to Bone." Cancers 12, no. 10 (2020): 3003. http://dx.doi.org/10.3390/cancers12103003.

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Patients with triple negative breast cancer (TNBC) is frequently complicated by bone metastasis, which deteriorates the life expectancy of this patient cohort. In order to develop a novel type of therapy for bone metastasis, we established 4T1.3 clone with a high capacity to metastasize to bone after orthotopic injection, from a murine TNBC cell line, 4T1.0. To elucidate the molecular mechanism underlying a high growth ability of 4T1.3 in a bone cavity, we searched for a novel candidate molecule with a focus on a transcription factor whose expression was selectively enhanced in a bone cavity.

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Jutzi, Jonas Samuel, Titiksha Basu, Maximilian Pellmann, et al. "Altered NFE2 activity predisposes to leukemic transformation and myelosarcoma with AML-specific aberrations." Blood 133, no. 16 (2019): 1766–77. http://dx.doi.org/10.1182/blood-2018-09-875047.

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Abstract In acute myeloid leukemia (AML), acquired genetic aberrations carry prognostic implications and guide therapeutic decisions. Clinical algorithms have been improved by the incorporation of novel aberrations. Here, we report the presence and functional characterization of mutations in the transcription factor NFE2 in patients with AML and in a patient with myelosarcoma. We previously described NFE2 mutations in patients with myeloproliferative neoplasms and demonstrated that expression of mutant NFE2 in mice causes a myeloproliferative phenotype. Now, we show that, during follow-up, 34%

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Loyd, Melanie R., Yasuhiro Okamoto, Mindy S. Randall та Paul A. Ney. "Role of AP1/NFE2 binding sites in endogenous α-globin gene transcription". Blood 102, № 12 (2003): 4223–28. http://dx.doi.org/10.1182/blood-2003-02-0574.

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Abstract High-level α-globin expression depends on cis-acting regulatory sequences located far upstream of the α-globin cluster. Sequences that contain the α-globin positive regulatory element (PRE) activate α-globin expression in transgenic mice. The α-globin PRE contains a pair of composite binding sites for the transcription factors activating protein 1 and nuclear factor erythroid 2 (AP1/NFE2). To determine the role of these binding sites in α-globin gene transcription, we mutated the AP1/NFE2 sites in the α-globin PRE in mice. We replaced the AP1/NFE2 sites with a neomycin resistance gene

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Amaru, Ariel, Katia Todoerti, Anna Pellicioli, et al. "The HDAC INHIBITOR ITF2357 MODULATES KEY HEMATOPOIETIC GENES in JAK2V617F CELLS From MYELOPROLIFERATIVE Neoplasm PATIENTS." Blood 116, no. 21 (2010): 797. http://dx.doi.org/10.1182/blood.v116.21.797.797.

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Abstract Abstract 797 We have previously shown that the pan-HDAC inhibitor ITF2357 has strong cytotoxic activity against cells from patients with myeloproliferative neoplasms (MPN) bearing JAK2 mutation at position 617. Indeed ITF2357 inhibited colony growth of JAK2V617F positive cells at doses 5–10 fold lower than those required to block JAK2 wild type cells. We have therefore investigated here the molecular mechanism of this effect. Three cell lines homozygotes (HEL, UKE1) or heterozygotes (SET2) for the JAK2V617F mutation were used along with cell lines bearing JAK2 wild type (K562 and KG1)

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Crispino, John D. "JAK2 and JMJD1C activate NFE2 in MPNs." Blood 131, no. 18 (2018): 1998–99. http://dx.doi.org/10.1182/blood-2018-03-839779.

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Kashif, M., A. Hellweg, M. Thati, et al. "O17 The transcription factor NFE2 regulates trophoblast differentiation." Thrombosis Research 123 (January 2009): S136. http://dx.doi.org/10.1016/s0049-3848(09)70042-8.

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Miller, JL, CE Walsh, PA Ney, RJ Samulski, and AW Nienhuis. "Single-copy transduction and expression of human gamma-globin in K562 erythroleukemia cells using recombinant adeno-associated virus vectors: the effect of mutations in NF-E2 and GATA-1 binding motifs within the hypersensitivity site 2 enhancer [published erratum appears in Blood 1995 Feb 1;85(3):862]." Blood 82, no. 6 (1993): 1900–1906. http://dx.doi.org/10.1182/blood.v82.6.1900.1900.

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Abstract The use of recombinant adeno-associated virus (rAAV) vectors provides a new strategy to investigate the role of specific regulatory elements and trans-acting factors in globin gene expression. We linked hypersensitivity site 2 (HS2) from the locus control region (LCR) to a A gamma-globin gene (A gamma*) mutationally marked to allow its transcript to be distinguished from endogenous gamma-globin mRNA. The vector also contains the phosphotransferase gene that confers resistance to neomycin (NeoR). HS2 region mutations within the NF-E2 motifs prevented NF-E2 binding while preserving AP-1

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Miller, JL, CE Walsh, PA Ney, RJ Samulski, and AW Nienhuis. "Single-copy transduction and expression of human gamma-globin in K562 erythroleukemia cells using recombinant adeno-associated virus vectors: the effect of mutations in NF-E2 and GATA-1 binding motifs within the hypersensitivity site 2 enhancer [published erratum appears in Blood 1995 Feb 1;85(3):862]." Blood 82, no. 6 (1993): 1900–1906. http://dx.doi.org/10.1182/blood.v82.6.1900.bloodjournal8261900.

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The use of recombinant adeno-associated virus (rAAV) vectors provides a new strategy to investigate the role of specific regulatory elements and trans-acting factors in globin gene expression. We linked hypersensitivity site 2 (HS2) from the locus control region (LCR) to a A gamma-globin gene (A gamma*) mutationally marked to allow its transcript to be distinguished from endogenous gamma-globin mRNA. The vector also contains the phosphotransferase gene that confers resistance to neomycin (NeoR). HS2 region mutations within the NF-E2 motifs prevented NF-E2 binding while preserving AP-1 binding.

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Xu, Wenchao, Jianzhou Liu, Qiaofei Liu, et al. "NFE2-driven neutrophil polarization promotes pancreatic cancer liver metastasis progression." Cell Reports 44, no. 2 (2025): 115226. https://doi.org/10.1016/j.celrep.2024.115226.

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Meechoowas, Ekarat, Parida Jampeerung, Kanit Tapasa, and Tepiwan Jitwatcharakomol. "The Decolorizing of High Iron Containing Soda-Lime Silicate Glass by Annealing Process." Key Engineering Materials 702 (July 2016): 130–34. http://dx.doi.org/10.4028/www.scientific.net/kem.702.130.

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The tableware soda-lime silicate glasses, contained with 0.06 wt% of iron oxide, which were annealed at different times and temperatures, were investigated by UV-Vis spectroscopy. The glasses were produced from high iron sand. The iron content was twice as high in the glasses as it is in normal tableware glasses. The redox reaction of iron around glass transition temperature, Fe2+(green) ↔ Fe3+(yellow), was found in the annealing process, according to the redox reaction of iron with polyvalent ions in the glass, nFe3+ + Ma+ ↔ nFe2+ + M(a+-n) where M is the polyvalent ion in glass. In this stud

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Zhang, Bing, and Tao Sun. "Transcription Factors That Regulate the Pathogenesis of Ulcerative Colitis." BioMed Research International 2020 (August 25, 2020): 1–9. http://dx.doi.org/10.1155/2020/7402657.

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Ulcerative colitis (UC) is one of the inflammatory bowel diseases (IBD) characterized by occurrence in the rectum and sigmoid colon of young adults. However, the functional roles of transcription factors (TFs) and their regulating target genes and pathways are not fully known in ulcerative colitis (UC). In this study, we collected gene expression data to identify differentially expressed TFs (DETFs). We found that differentially expressed genes (DEGs) were significantly enriched in the target genes of HOXA2, IKZF1, KLF2, XBP1, EGR2, ETV7, BACH2, CBFA2T3, HLF, and NFE2. TFs including BACH2, CBF

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Yang, Zhuo, Nai-Kei Wong, Fan Mao, et al. "Carnosine Synthase (TsATPGD) Alleviates Lipid Peroxidation Under Transcriptional Control by an Nfe2-like Gene in Tridacna Squamosa." Antioxidants 13, no. 11 (2024): 1351. http://dx.doi.org/10.3390/antiox13111351.

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As an important mollusk in reef ecosystems, Tridacna squamosa forms pro-survival symbiotic relationships that hinge on an exquisite redox equilibrium between the host and the photosynthetic symbiont, zooxanthellae. The exact regulatory mechanisms thereof remain poorly understood. In this study, a novel Nfe2-like transcription factor in T. squamosa was identified and characterized with respect to its antioxidant and cytoprotective roles. Gene structure and phylogenetic analysis reveal that T. squamosa possesses a single transcription factor TsNfe2l in contrast to mammalian Nfe2l1 (Nrf1) and Nfe

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Rheinemann, L., T. S. Seeger, J. Wehrle, and H. L. Pahl. "NFE2 regulates transcription of multiple enzymes in the heme biosynthesis pathway." Haematologica 99, no. 10 (2014): e208-e210. http://dx.doi.org/10.3324/haematol.2014.106393.

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Kashif, Muhammed, Andrea Hellwig, Said Hashemolhosseini, et al. "Nuclear Factor Erythroid-derived 2 (Nfe2) Regulates JunD DNA-binding Activity via Acetylation." Journal of Biological Chemistry 287, no. 8 (2011): 5400–5411. http://dx.doi.org/10.1074/jbc.m111.289801.

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Fallatah, Weam, Ronika De, David Burks, Rajeev K. Azad, and Pudur Jagadeeswaran. "Analysis of transcribed sequences from young and mature zebrafish thrombocytes." PLOS ONE 17, no. 3 (2022): e0264776. http://dx.doi.org/10.1371/journal.pone.0264776.

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The zebrafish is an excellent model system to study thrombocyte function and development. Due to the difficulties in separating young and mature thrombocytes, comparative transcriptomics between these two cell types has not been performed. It is important to study these differences in order to understand the mechanism of thrombocyte maturation. Here, we performed single-cell RNA sequencing of the young and mature zebrafish thrombocytes and compared the two datasets for young and mature thrombocyte transcripts. We found a total of 9143 genes expressed cumulatively in both young and mature throm

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Hormaeche, Itsaso, Kim L. Rice, Arthur Zelent, Melanie J. McConnell та Jonathan D. Licht. "PLZF-RARα Utilizes the Histone Methyl Transferase G9a/GLP and the Histone Demethylase LSD1 to Repress RARα Target Genes and Block Myeloid Differentiation". Blood 112, № 11 (2008): 198. http://dx.doi.org/10.1182/blood.v112.11.198.198.

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Abstract As a result of the t(11;17) translocation in retinoic acid resistant subtype of acute promyelocytic leukemia (APL), the transcriptional repression domains of the Promyelocytic Leukemia Zinc Finger protein (PLZF) are fused to the ligand binding and DNA binding domains of the Retinoic Acid Receptor α (RARα). The expression of PLZF-RARα as well as the reciprocal RARα-PLZF protein both appear to contribute to leukemogenesis. While the mode of action of PML-RARα has been studied in detail, less is known about transcriptional repression mediated by PLZF-RARα. We and others previously showed

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Gasiorek, Jadwiga J., and Volker Blank. "Regulation and function of the NFE2 transcription factor in hematopoietic and non-hematopoietic cells." Cellular and Molecular Life Sciences 72, no. 12 (2015): 2323–35. http://dx.doi.org/10.1007/s00018-015-1866-6.

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Opatz, Sabrina, Klaus H. Metzeler, Tobias Herold, et al. "The Mutatome of CBFB/MYH11-rearranged Acute Myeloid Leukemia (AML)." Blood 124, no. 21 (2014): 14. http://dx.doi.org/10.1182/blood.v124.21.14.14.

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Abstract The fusion gene CBFB/MYH11 results from a pericentric inversion of chromosome 16, inv(16)(p13.1q22), or less commonly from a t(16;16)(p13.1;q22). This rearrangement is found in 6-8% of adult de novo AML cases and associated with favourable prognosis. Physiologically, CBFB binds to RUNX1 forming the core binding factor (CBF), which is a transcription factor essential for normal hematopoiesis and myeloid development. By disrupting transcription factor activity of CBF, the CBFB/MYH11 fusion protein causes repression of the CBF-dependent target genes resulting in a block of differentiatio

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Kashif, M., T. Madhusudhan, S. U. E. Herzog, et al. "42 Absence of the transcription factor NFE2 impairs placental labyrinthine layer development during late midgestation." Thrombosis Research 119 (January 2007): S108. http://dx.doi.org/10.1016/s0049-3848(07)70087-7.

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Bae, Myoung Nam, Min Seok Choi, Sang-hoon Eum, et al. "Age-related Changes in the Sirtuin1-NFE2-related Factor 2 Signaling System in the Kidney." Korean Journal of Medicine 92, no. 1 (2017): 53–61. http://dx.doi.org/10.3904/kjm.2017.92.1.53.

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Bae, Myoung Nam, Min Seok Choi, Sang-hoon Eum, et al. "Age-related Changes in the Sirtuin1-NFE2-related Factor 2 Signaling System in the Kidney." Korean Journal of Medicine 92, no. 2 (2017): 224. http://dx.doi.org/10.3904/kjm.2017.92.1.53.e1.

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Aumann, Konrad, Martin Werner, and Heike L. Pahl. "Immunohistochemical staining of transcription factor NFE2 for the discrimination of primary myelofibrosis from essential thrombocythemia." Human Pathology 53 (July 2016): 195–96. http://dx.doi.org/10.1016/j.humpath.2016.02.024.

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Siegwart, Laura C., Sven Schwemmers, Julius Wehrle, et al. "The transcription factor NFE2 enhances expression of the hematopoietic master regulators SCL/TAL1 and GATA2." Experimental Hematology 87 (July 2020): 42–47. http://dx.doi.org/10.1016/j.exphem.2020.06.004.

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Keefer, Jeffrey R., Shirley H. Purvis, George J. Dover, and Kirby D. Smith. "Analysis of the X-Linked F-Cell Production Locus." Blood 106, no. 11 (2005): 3178. http://dx.doi.org/10.1182/blood.v106.11.3178.3178.

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Abstract This laboratory has previously identified a locus on the X chromosome at Xp22.2–22.3 (F-cell production locus or FCP) that is responsible for approximately 40% of the genetic variability in F-cell number in patients with sickle cell disease (SCD). We have re-examined the association of this region with F-cell production by multipoint linkage analysis. We have confirmed linkage to Xp22.2–22.3 and refined the candidate locus to a region of approximately 3 cM, between markers DXS452 and DXS410, with a maximum LOD score of 3.315. Linkage to a more extended region of 11 cM with an average

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Yin, Jun, Wei Liu, Yan Kai, Wan Yao Wang, and Liang Liang. "Study on Hair Dyeing Wastewater by Fenton Oxidation Method." Applied Mechanics and Materials 522-524 (February 2014): 168–71. http://dx.doi.org/10.4028/www.scientific.net/amm.522-524.168.

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Hair dyeing wastewater is produced in coloring process. Its composition is complicated,in which contains a large number of organic pollutants and high color. Hair dyeing wastewater treatment can be effectively treated by Fenton oxidation method. The experiment results show that hair dyeing wastewater is treated by Fenton oxidation in this thesis. Fenton reagent is affected by hair dyeing wastewater, pH reaction time and many other factors. When raw water COD is 3800mg/L and chroma is 1210 times, by using Fenton oxidation method determine best experimental conditions: concentration of H2O2 is 2

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Navas, Patrick A., Yongqi Yan, Minerva E. Sanchez, Ericka M. Johnson, and George Stamatoyannopoulos. "Talen-Mediated Knock Outs Of Cis and Trans Elements Potentially Involved In Globin Gene Switching." Blood 122, no. 21 (2013): 436. http://dx.doi.org/10.1182/blood.v122.21.436.436.

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Abstract Transcription activator-like effector nucleases (TALEN) are engineered proteins used for precise genome editing by generating specific DNA double strand that are repaired by homologous recombination and by non-homologous end joining. TALENs can be used to study gene regulation by deleting putative regulatory elements in the context of the native chromosome and measuring mRNA synthesis. We designed TALENs to delete individual DNAse I-hypersensitive sites (HS) of the β-globin locus control region (LCR) followed by an assessment of globin gene expression and assessment of epigenetic effe

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Williams, Larissa M., Alicia R. Timme-Laragy, Jared V. Goldstone, et al. "Developmental Expression of the Nfe2-Related Factor (Nrf) Transcription Factor Family in the Zebrafish, Danio rerio." PLoS ONE 8, no. 10 (2013): e79574. http://dx.doi.org/10.1371/journal.pone.0079574.

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Lazarevic, Vladimir, Christina Orsmark-Pietras, Henrik Lilljebjörn, et al. "Isolated myelosarcoma is characterized by recurrent NFE2 mutations and concurrent preleukemic clones in the bone marrow." Blood 131, no. 5 (2018): 577–81. http://dx.doi.org/10.1182/blood-2017-07-793620.

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Farley, Alison, Sarah Lloyd, Merle Dayton, Christine Biben, Olivia Stonehouse, and Samir Taoudi. "Severe thrombocytopenia is sufficient for fetal and neonatal intracerebral hemorrhage to occur." Blood 138, no. 10 (2021): 885–97. http://dx.doi.org/10.1182/blood.2020010111.

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Abstract Intracerebral hemorrhage (ICH) has a devastating impact on the neonatal population. Whether thrombocytopenia is sufficient to cause ICH in neonates is still being debated. In this study, we comprehensively investigated the consequences of severe thrombocytopenia on the integrity of the cerebral vasculature by using 2 orthogonal approaches: by studying embryogenesis in the Nfe2−/− mouse line and by using biologics (anti-GP1Bα antibodies) to induce severe thrombocytopenia at defined times during development. By using a mouse model, we acquired data demonstrating that platelets are requi

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Chang, Xue-Qin, Ling Xu, Yi-Xuan Zuo, Yi-Guo Liu, Jia Li, and Hai-Tao Chi. "Emerging trends and hotspots of Nuclear factor erythroid 2-related factor 2 in nervous system diseases." World Journal of Clinical Cases 11, no. 32 (2023): 7833–51. http://dx.doi.org/10.12998/wjcc.v11.i32.7833.

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BACKGROUND The Nuclear factor erythroid 2-related factor 2 (NRF2) transcription factor has attracted much attention in the context of neurological diseases. However, none of the studies have systematically clarified this field's research hotspots and evolution rules. AIM To investigate the research hotspots, evolution patterns, and future research trends in this field in recent years. METHODS We conducted a comprehensive literature search in the Web of Science Core Collection database using the following methods: (((((TS=(NFE2 L2)) OR TS=(Nfe2 L2 protein, mouse)) OR TS=(NF-E2-Related Factor 2)

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Zhang, Yong, Jianyong Wan, Shiqiang Liu, Tianmiao Hua, and Qingyan Sun. "Exercise induced improvements in insulin sensitivity are concurrent with reduced NFE2/miR-432-5p and increased FAM3A." Life Sciences 207 (August 2018): 23–29. http://dx.doi.org/10.1016/j.lfs.2018.05.040.

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Ziros, Panos G., Ioannis G. Habeos, Dionysios V. Chartoumpekis, et al. "NFE2-Related Transcription Factor 2 Coordinates Antioxidant Defense with Thyroglobulin Production and Iodination in the Thyroid Gland." Thyroid 28, no. 6 (2018): 780–98. http://dx.doi.org/10.1089/thy.2018.0018.

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Li, Bing, Shujun Liu, Lining Miao, and Lu Cai. "Prevention of Diabetic Complications by Activation of Nrf2: Diabetic Cardiomyopathy and Nephropathy." Experimental Diabetes Research 2012 (2012): 1–7. http://dx.doi.org/10.1155/2012/216512.

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Diabetic cardiomyopathy and nephropathy are two major causes of death of patients with diabetes. Extra generation of reactive oxygen species (ROS), induced by hyperglycemia, is considered as the main reason for the development of these diabetic complications. Transcription factor, NFE2-related factor 2 (Nrf2), is a master regulator of cellular detoxification response and redox status, and also provides a protective action from various oxidative stresses and damages. Recently we have demonstrated its important role in determining the susceptibility of cells or tissues to diabetes-induced oxidat

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Roberts, James A., Richard D. Rainbow, and Parveen Sharma. "Mitigation of Cardiovascular Disease and Toxicity through NRF2 Signalling." International Journal of Molecular Sciences 24, no. 7 (2023): 6723. http://dx.doi.org/10.3390/ijms24076723.

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Cardiovascular toxicity and diseases are phenomena that have a vastly detrimental impact on morbidity and mortality. The pathophysiology driving the development of these conditions is multifactorial but commonly includes the perturbance of reactive oxygen species (ROS) signalling, iron homeostasis and mitochondrial bioenergetics. The transcription factor nuclear factor erythroid 2 (NFE2)-related factor 2 (NRF2), a master regulator of cytoprotective responses, drives the expression of genes that provide resistance to oxidative, electrophilic and xenobiotic stresses. Recent research has suggeste

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Lichtenberg, Jens, Elisabeth F. Heuston, Cheryl A. Keller, Ross C. Hardison, and David M. Bodine. "Comparison of Expression and Epigenetic Profiles in Human and Mouse Erythropoiesis and Megakaryopoiesis Using a Systems Biology Model." Blood 126, no. 23 (2015): 2383. http://dx.doi.org/10.1182/blood.v126.23.2383.2383.

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Abstract To date numerous datasets of gene expression and epigenetic profiles for mouse and human hematopoietic cells have been generated. While individual data sets for a particular cell type have been correlated, no approach exists to harness all expression and epigenetic profiles for the different types of hematopoietic cells. Our goal is to develop a systems biology platform to compare epigenetic profiles of hematopoietic cells towards a better understanding of epigenetic mechanisms governing hematopoiesis. To provide the necessary foundation to support systematic studies of hematopoiesis,

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Yang, Weili, Junpei Wang, Zhenzhen Chen, et al. "NFE2 Induces miR-423-5p to Promote Gluconeogenesis and Hyperglycemia by Repressing the Hepatic FAM3A-ATP-Akt Pathway." Diabetes 66, no. 7 (2017): 1819–32. http://dx.doi.org/10.2337/db16-1172.

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