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Thèses sur le sujet « NK cell therapy »

Auteur : Grafiati

Publié le 9 mars 2023

Mis à jour le 31 juillet 2025

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1

Jaime-Ramirez, Alena Cristina. "HER2 and Folate Receptor Targeted Therapy is Enhanced by NK Cell-Activating Cytokines." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1364465780.

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2

Ojo, Evelyn. "Approaches to Improve the Proliferation and Activity of Natural Killer Cells for Adoptive Cell Therapy." Case Western Reserve University School of Graduate Studies / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=case1536760957918928.

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3

Wang, Siao-Yi. "Interactions between complement and cellular mediated mechanisms of monoclonal antibody therapy." Diss., University of Iowa, 2010. https://ir.uiowa.edu/etd/619.

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Monoclonal antibodies (mAbs) have become an important part of therapy for a number of cancers. The first mAb to be approved for clinical use is rituximab, which is currently used for the treatment of various B cell malignancies. Despite its clinical value, the mechanisms in which rituximab induces tumor regression are unclear. Growing evidence suggests that multiple mechanisms involving complement-dependent cytotoxicity (CDC) and antibody-dependent cellular cytotoxicity (ADCC) are involved. However, the direct interactions between CDC and ADCC have yet to be investigated. My studies examine th

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4

Suck, Garnet, Yeh Ching Linn, and Torsten Tonn. "Natural Killer Cells for Therapy of Leukemia." Karger, 2016. https://tud.qucosa.de/id/qucosa%3A71644.

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Clinical application of natural killer (NK) cells against leukemia is an area of intense investigation. In human leukocyte antigen-mismatched allogeneic hematopoietic stem cell transplantations (HSCT), alloreactive NK cells exert powerful anti-leukemic activity in preventing relapse in the absence of graft-versus-host disease, particularly in acute myeloid leukemia patients. Adoptive transfer of donor NK cells post-HSCT or in non-transplant scenarios may be superior to the currently widely used unmanipulated donor lymphocyte infusion. This concept could be further improved through transfusion

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5

Ewen, Eva-Maria [Verfasser], and Viktor [Akademischer Betreuer] Umansky. "Pro-inflammatory cytokines unleash natural killer cell potential for tumor therapy : NK cells want to break free / Eva-Maria Ewen ; Betreuer: Viktor Umansky." Heidelberg : Universitätsbibliothek Heidelberg, 2019. http://d-nb.info/1180394402/34.

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6

RAMBALDI, BENEDETTA. "Understanding T and NK cell reconstitution after allogeneic hematopoietic cell transplantation: a path to improve graft versus leukemia and minimize graft versus host disease." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2023. https://hdl.handle.net/10281/402375.

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Il trapianto di cellule ematopoietiche (HCT) rappresenta una terapia cardine per il trattamento delle neoplasie ematologiche altrimenti incurabili. Tuttavia, la procedura di trapianto può essere gravata dalla recidiva della malattia, dalla malattia del trapianto contro l'ospite (GVHD) e dalle infezioni. Le cellule T e NK che ricostituiscono dopo l'HCT proteggono da infezioni e recidive, ma sono anche coinvolte nella patogenesi della GVHD. Gli obiettivi del mio progetto di dottorato erano di migliorare la comprensione della ricostituzione delle cellule T e NK, utilizzando campioni di donatori s

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Kübler, Ayline [Verfasser], and Rupert [Akademischer Betreuer] Handgretinger. "Optimization of NK cell-based immune therapy strategies against pediatric acute B cell precursor leukemia using a human-murine xenotransplantation model / Ayline Kübler ; Betreuer: Rupert Handgretinger." Tübingen : Universitätsbibliothek Tübingen, 2015. http://d-nb.info/1163664618/34.

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8

Craperi, Delphine. "Thérapie génique des gliomes : caractérisation des voies cytotoxiques déclenchées par le système thymidine kinase herpétique/ganciclovir." Université Joseph Fourier (Grenoble ; 1971-2015), 1998. http://www.theses.fr/1998GRE10073.

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La therapie genique par transfert du gene de la thymidine kinase du virus de l'herpes simplex de type 1 (hsv1-tk) suivi d'un traitement avec la prodrogue ganciclovir (gcv) a ete utilisee pour le traitement de divers cancers. L'efficacite de cette therapie est en partie due a l'existence d'un effet de toxicite de voisinage : le traitement au ganciclovir entraine non seulement la mort des cellules exprimant hsv1-tk mais aussi celle des cellules adjacentes non transfectees. Nous avons entrepris une etude in vitro des mecanismes moleculaires de la toxicite de ce systeme enzyme/prodrogue sur des li

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9

GUOLO, FABIO. "POST-TRANSPLANT NIVOLUMAB PLUS UNSELECTED AUTOLOGOUS LYMPHOCYTES IN REFRACTORY HODGKIN LYMPHOMA PATIENTS: A SAFE AND EFFECTIVE THERAPY ASSOCIATED WITH EXPANSION AND MATURATION OF NK CELLS." Doctoral thesis, Università degli studi di Genova, 2021. http://hdl.handle.net/11567/1043790.

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Hodgkin Lymphoma (HL) is a B-Cell neoplasia with a favourable outcome in responding patients. However, despite the efficacy of first line therapy about 30% of patients eventually relapse or are refractory (R/R). Recently, the immune checkpoint inhibitor (CI) nivolumab demonstrated good activity in R/R HL patients although the complete response (CR) rate was less than 20%. The efficacy of nivolumab is strictly related to the host degree of immune competence, which is greatly impaired in heavily pre-treated HL patients after autologous stem cell transplantation (ASCT). To enhance the activity of

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10

Oh, Jun Seok. "Critical Roles of Cytomegalovirus-Induced Natural Killer Cells in Chronic Hepatitis C Virus Infection and Rituximab-Mediated Cancer Therapy." Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/36228.

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Natural Killer (NK) cells, members of the innate lymphoid cells (ILCs), are known to play an important role in the defense against foreign cells and abnormal host cells that have arisen due to viral infection or cancer inducing mutations. The typical immune response of NK cells involves the release of cytotoxic granules containing perforin and granzyme, and the secretion of immune-regulatory cytokines such as interferon gamma (IFN-γ). Unlike the adaptive lymphocytes such as T cells and B cells, NK cells do not require prior sensitization, enabling them to initiate an immune response much faste

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11

Fortenbery, Nicole Renee. "Regulation of Natural Killer Cells: SHIP-1, 2B4, and Immunomodulation by Lenalidomide." Scholar Commons, 2012. http://scholarcommons.usf.edu/etd/4043.

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Natural Killer cells (NK) are critical components of the innate immune system. Often referred to by their morphology, these large granular lymphocytes (LGLs) are bone marrow-derived lymphocytes and can be found throughout the body. NK cells reside in the liver, lymph nodes, spleen, thymus, and mucosal-associated lymphoid tissues (MALT). Importantly, NK cells also circulate throughout the blood where they function as surveyors of the body and are armed to eliminate malignant, infected, damaged, or foreign cells. NK cells function by a dual receptor system. That is, NK receptors are broadly cate

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12

Martin, Corredera Marta. "Development of a protocol to produce Natural Killer cells for therapeutic purposes." Electronic Thesis or Diss., Université Paris Cité, 2024. http://www.theses.fr/2024UNIP5244.

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Les cellules Natural Killer (NK), lymphocytes effecteurs de l'immunité innée, jouent un rôle essentiel dans l'élimination des cellules dont la fonction est altérée, comme les cellules tumorales ou les cellules infectées par un virus. Les cellules NK se distinguent des lymphocytes T par l'absence de récepteur spécifique pour l'antigène. Le mécanisme de cytotoxicité est induit par l'interaction entre des récepteurs d'activation présents à la surface des cellules NK et leurs ligands exprimés par les cellules cibles, sans nécessité de présentation antigénique. Elles présentent un intérêt particuli

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13

Buteyn, Nathaniel J. "Role of Innate Immunity Activators in the Treatment of Acute Myeloid Leukemia." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1574343556916953.

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14

Swift, Brenna. "Natural Killer Cell Line Therapy in Multiple Myeloma." Thesis, 2011. http://hdl.handle.net/1807/31456.

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Multiple myeloma (MM) is an incurable plasma cell malignancy. NK cells have demonstrated anti-MM activity in allogeneic transplants and donor lymphocyte infusions, and may provide a more effective therapy for MM. This work demonstrates cytotoxicity of NK-92 and KHYG-1 against MM cells in chromium release and flow cytometry cytotoxicity assays. At a 10:1 effector to target ratio, the cytotoxicity of NK cell lines against MM cells is 50-90%. Blocking NKp30 significantly reduces the cytotoxicity of NK-92 and KHYG-1, while blocking NKG2D and DNAM-1 only reduces the cytotoxicity of NK-92. Notably,

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15

Fonseca, Ana Patricia Ramos da. "Relatório de Estágio e Monografia intitulada “Células T CAR e novas abordagens terapêuticas: terapia combinada com vírus oncolítcos e células NK"." Master's thesis, 2020. http://hdl.handle.net/10316/93072.

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Relatório de Estágio do Mestrado Integrado em Ciências Farmacêuticas apresentado à Faculdade de Farmácia<br>Este trabalho está dividido em três partes: Dois relatórios de estágio (Parte I e II) ambos com uma análise SWOT identificativa dos pontos fortes, pontos fracos, ameaças e oportunidades encontradas ao longo do período de estágio. A primeira parte refere-se ao estágio em Assuntos Regulamentares de produtos cosméticos na BasePoint Consulting Services e a segunda parte refere-se ao estágio em farmácia comunitária, na Farmácia da Estação. Na terceira e última parte (Parte III) encontra-se a

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16

(10283939), Andrea M. Chambers. "IMMUNOTHERAPY OF SOLID TUMORS WITH IMMUNOMETABOLICALLY-RETARGETED NATURAL KILLER CELLS." Thesis, 2021.

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<div>Cancer is responsible for the second highest cause of death in the United States, and lung cancer accounts for 13% of new cancer diagnoses, with the highest rate of cancer death at 24%. Almost 85% of these cases represent non-small cell lung cancer (NSCLC), which includes lung adenocarcinoma, the most common NSCLC subtype. Traditional cancer treatments often only temporarily stop the spread of the disease, but immunotherapies, which are becoming a standard of care, are much more promising. Natural killer (NK) cells are powerful effectors of innate immunity, and genetically engineered NK c

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Gonçalves, Daniel da Silva. "Relatórios de Estágio e Monografia intitulada “Células CAR-NK – Nova proposta terapêutica em oncologia”." Master's thesis, 2019. http://hdl.handle.net/10316/88369.

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Relatório de Estágio do Mestrado Integrado em Ciências Farmacêuticas apresentado à Faculdade de Farmácia<br>A área da oncologia é e continuará a ser uma das que mais expansão continua a ter na ciência. É também nesta que se vão fazendo mais esforços e mais descobertas para que possam ser tratadas patologias deste tipo, de forma cada vez mais eficaz e com maior segurança e qualidade para os doentes. Assim, surgem as células CAR-NK em resposta a patologias oncológicas, como uma nova possibilidade de tratamento das mesmas. É sobre esta possibilidade que se debruça esta monografia e o objectivo da

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