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Articles de revues sur le sujet « Non-Contrast CT (NCCT) »

Auteur : Grafiati

Publié le 9 novembre 2024

Mis à jour le 31 juillet 2025

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1

Qazi, Shakeel, Emmad Qazi, Alexis T. Wilson, et al. "Identifying Thrombus on Non-Contrast CT in Patients with Acute Ischemic Stroke." Diagnostics 11, no. 10 (2021): 1919. http://dx.doi.org/10.3390/diagnostics11101919.

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The hyperdense sign is a marker of thrombus in non-contrast computed tomography (NCCT) datasets. The aim of this work was to determine optimal Hounsfield unit (HU) thresholds for thrombus segmentation in thin-slice non-contrast CT (NCCT) and use these thresholds to generate 3D thrombus models. Patients with thin-slice baseline NCCT (≤2.5 mm) and MCA-M1 occlusions were included. CTA was registered to NCCT, and three regions of interest (ROIs) were placed in the NCCT, including: the thrombus, contralateral brain tissue, and contralateral patent MCA-M1 artery. Optimal HU thresholds differentiatin

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Saifudin, Saifudin, and Catur Budi Saputra. "NOISE REDUCTION AT IMAGE NON CONTRAST CT-SCAN UROGRAPHY WITH USING ITERATIVE RECONSTRUCTION." SANITAS: Jurnal Teknologi dan Seni Kesehatan 12, no. 1 (2021): 15–20. http://dx.doi.org/10.36525/sanitas.2021.2.

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The CT Scan examination technique that in the last decade is popular in diagnosing urinary stones is NCCT Urography examination. This examination is fast and informative, but this examination has a deficiency that the resulting image has a fairly high noise. Iterative Reconstruction is a method of algorithm reconstruction on CT Scan with the basic principle of estimating data to produce reconstruction image by reducing noise. The purpose of this study was to find out the difference in noise value in the use of Iterative Reconstruction in reducing noise and improving the quality of NCCT Urograp

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Naylor, Jillian, Leonid Churilov, Ziyuan Chen, Miriam Koome, Neil Rane, and Bruce C. V. Campbell. "Reliability, Reproducibility and Prognostic Accuracy of the Alberta Stroke Program Early CT Score on CT Perfusion and Non-Contrast CT in Hyperacute Stroke." Cerebrovascular Diseases 44, no. 3-4 (2017): 195–202. http://dx.doi.org/10.1159/000479707.

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Background: Alberta Stroke Program Early CT Score (ASPECTS) assesses early ischemic change on non-contrast CT (NCCT). We hypothesised that assessing ASPECTS regions on CT Perfusion (CTP) rather than NCCT would improve inter-rater agreement and prognostic accuracy, particularly in patients presenting early after stroke onset. Methods: Ischemic stroke patients treated with intravenous alteplase from 2009 to 2014 at our institution were included in this study. Inter-rater agreement and prognostic accuracy of ASPECTS across modalities were analysed by the time between stroke onset and initial NCCT

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Mattay, Raghav R., Lane Miner, Alexander Z. Copelan, et al. "Unruptured Arteriovenous Malformations in the Multidetector Computed Tomography Era: Frequency of Detection and Predictable Failures." Journal of Clinical Imaging Science 12 (February 18, 2022): 5. http://dx.doi.org/10.25259/jcis_200_2021.

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Objectives: While hemorrhage arising from ruptured arteriovenous malformations (AVMs) is usually evident on multidetector non-contrast computed tomography (NCCT), unruptured AVMs can be below the limits of detection. We performed a retrospective review of NCCT of patients with a proven diagnosis of unruptured AVM to determine if advances in CT technology have made them more apparent and what features predict their detection. Material and Methods: Twenty-five NCCTs met inclusion criteria of having angiography or MR proven AVM without hemorrhage, prior surgery, or other CNS disease. Demographic

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Avsenik, Jernej, Janja Pretnar Oblak, and Katarina Surlan Popovic. "Non-contrast computed tomography in the diagnosis of cerebral venous sinus thrombosis." Radiology and Oncology 50, no. 3 (2016): 263–68. http://dx.doi.org/10.1515/raon-2016-0026.

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Abstract Background The aim of the study was to investigate the sensitivity and specificity of non-contrast computed tomography (NCCT) in the diagnosis of cerebral venous sinus thrombosis (CVST). Methods. Screening our neurological department database, we identified 53 patients who were admitted to neurological emergency department with clinical signs of CVST. Two independent observers assessed the NCCT scans for the presence of CVST. CT venography and/or MR venography were used as a reference standard. Interobserver agreement between the two readers was assessed using Kappa statistic. Attenua

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GER AKARSU, Fatma, Ezgi SEZER ERYILDIZ, Özlem AYKAÇ, Zehra UYSAL KOCABAŞ, and Atilla Özcan Özdemir. "ASPECTS as a clinical outcome marker for MCA infarction treated with thrombolytic therapy: Non-contrast CT versus CTA source images." Neurology Asia 27, no. 2 (2022): 247–53. http://dx.doi.org/10.54029/2022kmj.

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Background & Objective: Computed tomography angiography (CTA) in acute stroke has been widely used to demonstrate arterial occlusion. Alberta Stroke Program Early CT Score (ASPECTS) is used to detect early ischemic signs in non-contrast computed tomography (NCCT) in the middle cerebral artery region. We hypothesized that computed tomography angiography source image (CTA-SI) is superior to NCCT in predicting final infarct volume, 24 hour National Institutes of Health Stroke Scale (NIHSS) score and 90-day clinical outcome. Methods: Patients who had an acute ischemic stroke due to middle cere

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Ma, Zhuangxuan, Liang Jin, Lukai Zhang, et al. "Diagnosis of Acute Aortic Syndromes on Non-Contrast CT Images with Radiomics-Based Machine Learning." Biology 12, no. 3 (2023): 337. http://dx.doi.org/10.3390/biology12030337.

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We aimed to detect acute aortic syndromes (AAS) on non-contrast computed tomography (NCCT) images using a radiomics-based machine learning model. A total of 325 patients who underwent aortic CT angiography (CTA) were enrolled retrospectively from 2 medical centers in China to form the internal cohort (230 patients, 60 patients with AAS) and the external testing cohort (95 patients with AAS). The internal cohort was divided into the training cohort (n = 135), validation cohort (n = 49), and internal testing cohort (n = 46). The aortic mask was manually delineated on NCCT by a radiologist. Least

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Zhang, Guirong, Pan Zhang, Yuwei Xia, Feng Shi, Yuelang Zhang, and Dun Ding. "Radiomics Analysis of Whole-Kidney Non-Contrast CT for Early Identification of Chronic Kidney Disease Stages 1–3." Bioengineering 12, no. 5 (2025): 454. https://doi.org/10.3390/bioengineering12050454.

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Background: The early stages of chronic kidney disease (CKD) are often undetectable on traditional non-contrast computed tomography (NCCT) images through visual assessment by radiologists. This study aims to evaluate the potential of radiomics-based quantitative features extracted from NCCT, combined with machine learning techniques, in differentiating CKD stages 1–3 from healthy controls. Methods: This retrospective study involved 1099 CKD patients (stages 1–3) and 1099 healthy participants who underwent NCCT. Bilateral kidney volumes of interest were automatically segmented using a deep lear

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Schön, Felix, Hannes Wahl, Arne Grey, et al. "Improved Visualization and Quantification of Net Water Uptake in Recent Small Subcortical Infarcts in the Thalamus Using Computed Tomography." Diagnostics 13, no. 22 (2023): 3416. http://dx.doi.org/10.3390/diagnostics13223416.

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Diagnosing recent small subcortical infarcts (RSSIs) via early computed tomography (CT) remains challenging. This study aimed to assess CT attenuation values (Hounsfield Units (HU)) and net water uptake (NWU) in RSSI and explore a postprocessing algorithm’s potential to enhance thalamic RSSI detection. We examined non-contrast CT (NCCT) data from patients with confirmed thalamic RSSI on diffusion-weighted magnetic resonance imaging (DW-MRI) between January 2010 and October 2017. Co-registered DW-MRI and NCCT images enabled HU and NWU quantification in the infarct area compared to unaffected co

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Toh, Tsun-Haw, Khairul Azmi Abdul Kadir, Mei-Ling Sharon Tai, and Kay Sin Tan. "Acute Ischaemic Stroke Successfully Treated with Thrombolytic Therapy and Endovascular Thrombectomy with Non-Contrast Computed Tomography and Computed Tomography Angiogram Protocol." Case Reports in Neurology 12, Suppl. 1 (2020): 15–21. http://dx.doi.org/10.1159/000501820.

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Early endovascular thrombectomy leads to improved outcomes for patients with proximal occlusions when started within 6 h from onset of symptoms. We present a case illustrating the flow of events for a patient who underwent endovascular thrombectomy in our centre after conventional imaging – a brain non-contrast computed tomography (NCCT) and CT angiogram (CTA) – achieving a door-to-groin time of 195 min. The patient is a 65-year-old who presented with signs and symptoms of a left middle cerebral artery (MCA) territory infarct. His National Institute of Health Stroke Scale (NIHSS) score was 15

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Gariani, Joanna, Victor Cuvinciuc, Delphine Courvoisier, et al. "Diagnosis of acute ischemia using dual energy CT after mechanical thrombectomy." Journal of NeuroInterventional Surgery 8, no. 10 (2015): 996–1000. http://dx.doi.org/10.1136/neurintsurg-2015-011988.

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Background and purposeTo assess the performance of dual energy unenhanced CT in the detection of acute ischemia after mechanical thrombectomy.MethodsRetrospective study, approved by the local institutional review board, including all patients that underwent intra-arterial thrombectomy in our institution over a period of 2 years. The presence of acute ischemia and hemorrhage was evaluated by three readers. Sensitivity and specificity of the non-contrast CT weighted sum image (NCCT) and the virtual non-contrast reconstructed image (VNC) were estimated and compared using generalized estimating eq

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Ezzeddine, Mustapha A., Walter J. Koroshetz, Sam Lah, Gilberto Gonzalez, and Michael H. Lev. "Hemispheric Infarct Volume Prediction by CT perfusion imaging." Stroke 32, suppl_1 (2001): 343. http://dx.doi.org/10.1161/str.32.suppl_1.343-b.

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P24 Objective: The ability to predict infarct volume when evaluating acute stroke patients is difficult. Bolus contrast CT perfusion imaging (CTP) with fast helical scanning, can identify that portion of ischemic brain with vasculature that does not fill with CT contrast. We evaluated the ability of this acute CTP lesion volume to predict final infarct volume. Methods: 18 patients were selected from our acute stroke database. Inclusion criteria were a CT Angiogram within 6 hours of a major stroke-like symptoms, a follow up brain imaging study no later than 30 days and no earlier than 36 hours,

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Ali, N. Imdad, Noor Elahi Pasha, and Ravishankar T.H.S. "Diagnostic Accuracy of Ultrasound and Plain X-Ray KUB (Kidney, Ureter, Bladder) Compared to Non-Contrast CT (Computed Tomography) in Patients of Ureteric Calculi." Journal of Evidence Based Medicine and Healthcare 7, no. 47 (2020): 2762–66. http://dx.doi.org/10.18410/jebmh/2020/567.

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BACKGROUND Imaging plays a major role in the diagnosis and management of patients with urolithiasis. Non-Contrast Computed Tomography (NCCT) is generally accepted as the gold standard, but there are concerns over higher radiation exposure from NCCT to the patient population. Our prospective study compared the diagnostic accuracy of plain X-ray KUB (Kidney, Ureter, Bladder) and USG (Ultrasonography) with NCCT in the evaluation of patients with ureteric colic. METHODS This study conducted from December 2018 to January 2020 in the Department of Urology, Vijayanagar Institute of Medical Sciences,

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Agrawal, Basudev, and Rupesh Verma. "Correlation of Glasgow Coma Scale with Non-Contrast Computed Tomography findings in immediate post traumatic brain injury." International Journal of Research in Medical Sciences 7, no. 4 (2019): 1059. http://dx.doi.org/10.18203/2320-6012.ijrms20191077.

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Background: This study was undertaken to correlate Glasgow Coma Scale (GCS) score with Non-Contrast Computed Tomography (NCCT) findings in patients with acute traumatic brain injury (TBI) attending tertiary care Shree Narayana Hospital, Raipur, Chhattisgarh, India.Methods: A cross-sectional study was performed among 100 patients of acute traumatic head injury (those presenting to hospital within 24 hours of injury) over a period of six months. The patient’s GCS score was determined and NCCT Brain scan was performed in each case immediately (within 30 minutes) after presenting to casualty of th

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Gębka, Michał, Anna Bajer-Czajkowska, Sandra Pyza, Krzysztof Safranow, Wojciech Poncyljusz, and Marcin Sawicki. "Evolution of Hypodensity on Non-Contrast CT in Correlation with Collaterals in Anterior Circulation Stroke with Successful Endovascular Reperfusion." Journal of Clinical Medicine 11, no. 2 (2022): 446. http://dx.doi.org/10.3390/jcm11020446.

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Introduction: The aim of the study was to assess the impact of collaterals on the evolution of hypodensity on non-contrast CT (NCCT) in anterior circulation stroke with reperfusion by mechanical thrombectomy (MT). Methods: We retrospectively included stroke patients with middle cerebral artery occlusion who were reperfused by MT in early and late time window. Artificial intelligence (AI)-based software was used to calculate of hypodensity volumes at baseline NCCT (V1) and at follow-up NCCT 24 h after MT (V2), along with the difference between the two volumes (V2-V1) and the follow-up (V2)/base

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Fitzgerald, Sean T., Shunli Wang, Daying Dai, et al. "Platelet-rich clots as identified by Martius Scarlet Blue staining are isodense on NCCT." Journal of NeuroInterventional Surgery 11, no. 11 (2019): 1145–49. http://dx.doi.org/10.1136/neurintsurg-2018-014637.

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BackgroundCurrent studies on clot characterization in acute ischemic stroke focus on fibrin and red blood cell composition. Few studies have examined platelet composition in acute ischemic stroke clots. We characterize clot composition using the Martius Scarlet Blue stain and assess associations between platelet density and CT density.Materials and methodHistopathological analysis of the clots collected as part of the multi-institutional STRIP registry was performed using Martius Scarlet Blue stain and the composition of the clots was quantified using Orbit Image Analysis (www.orbit.bio) machi

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Elawadi, A. A., Safa AlMohsen, Reham AlGendy, et al. "The Effect of Contrast Agents on Dose Calculations of Volumetric Modulated Arc Radiotherapy Plans for Critical Structures." Applied Sciences 11, no. 18 (2021): 8355. http://dx.doi.org/10.3390/app11188355.

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Radiotherapy dose calculation requires accurate Computed Tomography (CT) imaging while tissue delineation may necessitate the use of contrast agents (CA). Acquiring these two sets is a common practice in radiotherapy. This study aims to evaluate the effect of CA on the dose calculations. Two hundred and twenty-six volumetric modulated arc therapy (VMAT) patients that had planning CT with contrast (CCT) and non-contrast CT (NCCT) of different cancer sites (e.g., brain, head, and neck (H&N), chest, abdomen, and pelvis) were evaluated. Treatment plans were recalculated using CCT, then compare

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Sporns, Peter, Rene Schmidt, Jens Minnerup, et al. "Computed Tomography Perfusion Improves Diagnostic Accuracy in Acute Posterior Circulation Stroke." Cerebrovascular Diseases 41, no. 5-6 (2016): 242–47. http://dx.doi.org/10.1159/000443618.

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Background and Purpose: Computed tomography perfusion (CTP) has a high diagnostic value in the detection of acute ischemic stroke in the anterior circulation. However, the diagnostic value in suspected posterior circulation (PC) stroke is uncertain, and whole brain volume perfusion is not yet in widespread use. We therefore studied the additional value of whole brain volume perfusion to non-contrast CT (NCCT) and CT angiography source images (CTA-SI) for infarct detection in patients with suspected acute ischemic PC stroke. Methods: This is a retrospective review of patients with suspected str

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Chiang, Pi-Ling, Shih-Yen Lin, Meng-Hsiang Chen, et al. "Deep Learning-Based Automatic Detection of ASPECTS in Acute Ischemic Stroke: Improving Stroke Assessment on CT Scans." Journal of Clinical Medicine 11, no. 17 (2022): 5159. http://dx.doi.org/10.3390/jcm11175159.

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(1) Background: The Alberta Stroke Program Early CT Score (ASPECTS) is a standardized scoring tool used to evaluate the severity of acute ischemic stroke (AIS) on non-contrast CT (NCCT). Our aim in this study was to automate ASPECTS. (2) Methods: We utilized a total of 258 patient images with suspected AIS symptoms. Expert ASPECTS readings on NCCT were used as ground truths. A deep learning-based automatic detection (DLAD) algorithm was developed for automated ASPECTS scoring based on 168 training patient images using a convolutional neural network (CNN) architecture. An additional 90 testing

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Beaulieu, Marie-Claude, Ahmad Nehme, Francis Fortin, et al. "Non-Contrast CT and CT-Angiogram for Late Window Ischemic Stroke Treatment Selection." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 47, no. 3 (2020): 309–13. http://dx.doi.org/10.1017/cjn.2020.15.

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ABSTRACT:Introduction:The benefit of late window endovascular treatment (EVT) for anterior circulation ischemic stroke has been demonstrated using perfusion-based neuroimaging. We evaluated whether non-contrast CT (NCCT) and CT-angiogram (CTA) alone can select late-presenting patients for EVT.Methods:We performed a retrospective comparison of all patients undergoing EVT at a single comprehensive stroke center from January 2016 to April 2017. Patients planned for EVT were divided into early (<6 hours from onset) and late (≥6 hours from onset or last time seen normal) window groups. Incidence

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Zimmer, Sebastian, Jörn Meier, Jens Minnerup, et al. "Prognostic Value of Non-Contrast CT Markers and Spot Sign for Outcome Prediction in Patients with Intracerebral Hemorrhage under Oral Anticoagulation." Journal of Clinical Medicine 9, no. 4 (2020): 1077. http://dx.doi.org/10.3390/jcm9041077.

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Introduction: In patients with spontaneous intracerebral hemorrhage (ICH), several non-contrast computed tomography (NCCT) markers and the spot sign (SS) in computed tomography (CT) angiography (CTA) have been established for the prediction of hematoma growth and neurological outcome. However, the prognostic value of these markers in patients under oral anticoagulation (ORAC) is unclear. We hypothesized that outcome prediction by these imaging markers may be significantly different between patients with and without ORAC. Therefore, we aimed to investigate the predictive value of NCCT markers a

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Kuang, Hulin, Xianzhen Tan, Jie Wang, et al. "Segmenting Ischemic Penumbra and Infarct Core Simultaneously on Non-Contrast CT of Patients with Acute Ischemic Stroke Using Novel Convolutional Neural Network." Biomedicines 12, no. 3 (2024): 580. http://dx.doi.org/10.3390/biomedicines12030580.

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Differentiating between a salvageable Ischemic Penumbra (IP) and an irreversibly damaged Infarct Core (IC) is important for therapy decision making for acute ischemic stroke (AIS) patients. Existing methods rely on Computed Tomography Perfusion (CTP) or Diffusion-Weighted Imaging–Fluid Attenuated Inversion Recovery (DWI-FLAIR). We designed a novel Convolutional Neural Network named I2PC-Net, which relies solely on Non-Contrast Computed Tomography (NCCT) for the automatic and simultaneous segmentation of the IP and IC. In the encoder, Multi-Scale Convolution (MSC) blocks were proposed to captur

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Xu, Yuancheng, Stanislau Hrybouski, D. Ian Paterson, et al. "Comparison of epicardial adipose tissue volume quantification between ECG-gated cardiac and non-ECG-gated chest computed tomography scans." BMC Cardiovascular Disorders 22, no. 1 (2022). http://dx.doi.org/10.1186/s12872-022-02958-2.

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Abstract Background This study investigated accuracy and consistency of epicardial adipose tissue (EAT) quantification in non-ECG-gated chest computed tomography (CT) scans. Methods EAT volume was semi-automatically quantified using a standard Hounsfield unit threshold (− 190, − 30) in three independent cohorts: (1) Cohort 1 (N = 49): paired 120 kVp ECG-gated cardiac non-contrast CT (NCCT) and 120 kVp non-ECG-gated chest NCCT; (2) Cohort 2 (N = 34): paired 120 kVp cardiac NCCT and 100 kVp non-ECG-gated chest NCCT; (3) Cohort 3 (N = 32): paired non-ECG-gated chest NCCT and chest contrast-enhanc

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Choi, Jae Won, Yeon Jin Cho, Ji Young Ha, et al. "Generating synthetic contrast enhancement from non-contrast chest computed tomography using a generative adversarial network." Scientific Reports 11, no. 1 (2021). http://dx.doi.org/10.1038/s41598-021-00058-3.

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AbstractThis study aimed to evaluate a deep learning model for generating synthetic contrast-enhanced CT (sCECT) from non-contrast chest CT (NCCT). A deep learning model was applied to generate sCECT from NCCT. We collected three separate data sets, the development set (n = 25) for model training and tuning, test set 1 (n = 25) for technical evaluation, and test set 2 (n = 12) for clinical utility evaluation. In test set 1, image similarity metrics were calculated. In test set 2, the lesion contrast-to-noise ratio of the mediastinal lymph nodes was measured, and an observer study was conducted

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Morotti, Andrea, Qi Li, Valentina Mazzoleni, et al. "Non-contrast CT Markers of Intracerebral Hemorrhage Expansion: The influence of onset-to-CT time." International Journal of Stroke, November 22, 2022, 174749302211427. http://dx.doi.org/10.1177/17474930221142742.

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Background: Hematoma expansion (HE) is an appealing therapeutic target in intracerebral hemorrhage (ICH) and non-contrast computed tomography (NCCT) features are promising predictors of HE. Aims: We investigated whether onset-to-CT time influences the diagnostic performance of NCCT markers for HE. Methods: retrospective multicentre analysis of patients with primary ICH. The following NCCT markers were analyzed: hypodensities, heterogeneous density, blend sign, and irregular shape. HE was defined as growth > 6 mL and/or > 33%. We calculated the sensitivity, specificity, positive and negat

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Nawabi, Jawed, Frieder Schlunk, Andrea Dell Orco, et al. "Non-contrast computed tomography features predict intraventricular hemorrhage growth." European Radiology, May 22, 2023. http://dx.doi.org/10.1007/s00330-023-09707-9.

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Abstract Objectives Non-contrast computed tomography (NCCT) markers are robust predictors of parenchymal hematoma expansion in intracerebral hemorrhage (ICH). We investigated whether NCCT features can also identify ICH patients at risk of intraventricular hemorrhage (IVH) growth. Methods Patients with acute spontaneous ICH admitted at four tertiary centers in Germany and Italy were retrospectively included from January 2017 to June 2020. NCCT markers were rated by two investigators for heterogeneous density, hypodensity, black hole sign, swirl sign, blend sign, fluid level, island sign, satell

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Wolman, Dylan N., Fasco van Ommen, Elizabeth Tong, et al. "Non-contrast dual-energy CT virtual ischemia maps accurately estimate ischemic core size in large-vessel occlusive stroke." Scientific Reports 11, no. 1 (2021). http://dx.doi.org/10.1038/s41598-021-85143-3.

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AbstractDual-energy CT (DECT) material decomposition techniques may better detect edema within cerebral infarcts than conventional non-contrast CT (NCCT). This study compared if Virtual Ischemia Maps (VIM) derived from non-contrast DECT of patients with acute ischemic stroke due to large-vessel occlusion (AIS-LVO) are superior to NCCT for ischemic core estimation, compared against reference-standard DWI-MRI. Only patients whose baseline ischemic core was most likely to remain stable on follow-up MRI were included, defined as those with excellent post-thrombectomy revascularization or no perfus

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"Benefit of Contrast-Enhanced PET/CT versus Non-Contrast-Enhanced PET/CT Relative to Lesion Detection, Lesion Characterization, and Diagnostic Accuracy in Patients with Cancer." Journal of the Medical Association of Thailand 103, no. 9 (2020): 904–13. http://dx.doi.org/10.35755/jmedassocthai.2020.09.10643.

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Objective: To investigate the benefit of contrast-enhanced PET/CT (PET/CECT) versus non-contrast-enhanced PET/CT (PET/NCCT) relative to lesion detection, characterization, and diagnostic accuracy in cancer patients. Materials and Methods: The present study was a prospective study that included patients older than 18 years with histopathologically proven cancer who underwent [F-18] fluorodeoxyglucose ([F-18]FDG) PET/CT at the Division of Nuclear Medicine, Department of Radiology, Faculty of Medicine, Siriraj Hospital between December 2014 and November 2017. PET/NCCT was performed followed by PE

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Hablas, Lina Tarek, Alshimaa Magdy Ammar, and Rehab Mohamed Elnagar. "CSF rhinorrhea: non-contrast CT, contrast-enhanced CT cisternography or combined?" Egyptian Journal of Radiology and Nuclear Medicine 53, no. 1 (2022). http://dx.doi.org/10.1186/s43055-022-00889-8.

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Abstract Background Radiologic diagnosis of CSF leaks is challenging. We evaluated the diagnostic value of non-contrast CT and contrast-enhanced CT cisternography in identifying the presence of CSF rhinorrhea and site of leak as well as comparing them to surgical data and/or clinical follow-up. Results Fifty patients (20 males and 30 females) were included in our study with age ranging from 19 to 67 years. 76% of cases had spontaneous CSF rhinorrhea. Cribriform plate defect was the most common site of CSF leak, accounting for about 50% of cases. The highest sensitivity, specificity, PPV and NP

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McVerry, Ferghal, Krishna A. Dani, Niall J. MacDougall, and Keith W. Muir. "Abstract 3417: Pixel by Pixel Comparison of CTP-Defined Infarct Core on Concurrent Non-Contrast CT." Stroke 43, suppl_1 (2012). http://dx.doi.org/10.1161/str.43.suppl_1.a3417.

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Introduction Interobserver agreement for the presence of early ischemic changes on non-contrast CT (NCCT) in potential thrombolysis candidates can be poor even among experienced raters. CT perfusion (CTP) may demonstrate infarct core and penumbra according to proposed thresholds but the extent of correlation between CTP defined core and hypodensity on hyperacute NCCT is unclear Methods A pixel by pixel comparison between NCCT and concurrent CTP obtained <6hrs from symptom onset was performed for patients with symptomatic arterial occlusions. Segmentation was performed using time-averaged CT

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Sahoo, Prasan Kumar, Sulagna Mohapatra, Ching-Yi Wu, Kuo-Lun Huang, Ting-Yu Chang, and Tsong-Hai Lee. "Automatic identification of early ischemic lesions on non-contrast CT with deep learning approach." Scientific Reports 12, no. 1 (2022). http://dx.doi.org/10.1038/s41598-022-22939-x.

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AbstractEarly ischemic lesion on non-contrast computed tomogram (NCCT) in acute stroke can be subtle and need confirmation with magnetic resonance (MR) image for treatment decision-making. We retrospectively included the NCCT slices of 129 normal subjects and 546 ischemic stroke patients (onset < 12 h) with corresponding MR slices as reference standard from a prospective registry of Chang Gung Research Databank. In model selection, NCCT slices were preprocessed and fed into five different pre-trained convolutional neural network (CNN) models including Visual Geometry Group 16 (VGG16), Resid

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Shahrouki, Puja, Shingo Kihira, Elham Tavakkol, et al. "Automated assessment of ischemic core on non-contrast computed tomography: a multicenter comparative analysis with CT perfusion." Journal of NeuroInterventional Surgery, November 2, 2023, jnis—2023–020954. http://dx.doi.org/10.1136/jnis-2023-020954.

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BackgroundApplication of machine learning (ML) algorithms has shown promising results in estimating ischemic core volumes using non-contrast CT (NCCT).ObjectiveTo assess the performance of the e-Stroke Suite software (Brainomix) in assessing ischemic core volumes on NCCT compared with CT perfusion (CTP) in patients with acute ischemic stroke.MethodsIn this retrospective multicenter study, patients with anterior circulation large vessel occlusions who underwent pretreatment NCCT and CTP, successful reperfusion (modified Thrombolysis in Cerbral Infarction ≥2b), and post-treatment MRI, were inclu

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Christensen, Soren, Christian Federau, Julian Maclaren, Aditya Srivatsan, Greg Albers, and Maarten Lansberg. "Abstract TP64: Ischemic Stroke Lesion Identification in Non-Contrast CT Using Deep Learning." Stroke 51, Suppl_1 (2020). http://dx.doi.org/10.1161/str.51.suppl_1.tp64.

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Background: Automatic measurement of the acute stroke lesion volume on DWI and CT-CBF has been used in recent late window trials. Despite non-contrast CT (NCCT) being the most widely used imaging modality in the acute stroke setting, quantification of acute stroke volumes on NCCT has not been employed in trials because of the difficulty outlining territory with very mild Hounsfield unit depression. Deep learning algorithms have been effective at solving many image processing tasks and may outperform human readers given enough training data. The goal of this study was to train and test a deep l

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Mussmann, Bo, Peter Marshall Skov, Morten H. Lorentzen, et al. "Ultra-low-dose emergency chest computed tomography protocols in three vendors: A technical note." Acta Radiologica Open 12, no. 3 (2023). http://dx.doi.org/10.1177/20584601231183900.

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Background In suspected community-acquired pneumonia (CAP), chest CT is superior to the routinely obtained radiographs (CXR), but administers higher radiation doses. However, ultra-low-dose CT (ULDCT) has shown promising results. Purpose To compare radiation dose and image quality using standard and ULDCT protocols designed for a multicenter study encompassing three CT scanner models from GE, Canon, and Siemens. Material and methods Patients with suspected CAP were referred for non-contrast standard dose chest CT (NCCT) and ULDCT. Effective radiation dose and Contrast-to-Noise Ratio (CNR) was

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Imarhia, Frances, Soren Christensen, Maarten G. Lansberg, Adam Wang, Jeremy J. Heit, and Greg Albers. "Abstract WP103: Comparison Of Acute Infarct Lesions Between Non-contrast CT, DWI And FLAIR Using Back-to-back Imaging." Stroke 53, Suppl_1 (2022). http://dx.doi.org/10.1161/str.53.suppl_1.wp103.

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Introduction: Size and location of the acute infarct is a major determinant of stroke outcome and eligibility for therapy. Recently, there have been efforts to train deep learning networks to detect lesions on Non-Contrast CT (NCCT) using concurrent DWI imaging as the gold standard. However, little is known about the radiological correspondence between concurrent NCCT and DWI lesion sizes. We performed an exploratory analysis comparing the stroke lesion volume on acute NCCT to that on DWI and FLAIR images performed shortly after. Methods: Population: DEFUSE 3 trial patients scanned 6-16h after

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Wang, Chengyan, Zhang Shi, Ming Yang, et al. "Deep learning-based identification of acute ischemic core and deficit from non-contrast CT and CTA." Journal of Cerebral Blood Flow & Metabolism, June 8, 2021, 0271678X2110236. http://dx.doi.org/10.1177/0271678x211023660.

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The accurate identification of irreversible infarction and salvageable tissue is important in planning the treatments for acute ischemic stroke (AIS) patients. Computed tomographic perfusion (CTP) can be used to evaluate the ischemic core and deficit, covering most of the territories of anterior circulation, but many community hospitals and primary stroke centers do not have the capability to perform CTP scan in emergency situation. This study aimed to identify AIS lesions from widely available non-contrast computed tomography (NCCT) and CT angiography (CTA) using deep learning. A total of 345

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Zhai, Zhiwei, Sanne G. M. van Velzen, Nikolas Lessmann, Nils Planken, Tim Leiner, and Ivana Išgum. "Learning coronary artery calcium scoring in coronary CTA from non-contrast CT using unsupervised domain adaptation." Frontiers in Cardiovascular Medicine 9 (September 12, 2022). http://dx.doi.org/10.3389/fcvm.2022.981901.

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Deep learning methods have demonstrated the ability to perform accurate coronary artery calcium (CAC) scoring. However, these methods require large and representative training data hampering applicability to diverse CT scans showing the heart and the coronary arteries. Training methods that accurately score CAC in cross-domain settings remains challenging. To address this, we present an unsupervised domain adaptation method that learns to perform CAC scoring in coronary CT angiography (CCTA) from non-contrast CT (NCCT). To address the domain shift between NCCT (source) domain and CCTA (target)

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Sun, Yingli, Wei Zhao, Kaiming Kuang, et al. "Non-contrast and contrast enhanced computed tomography radiomics in preoperative discrimination of lung invasive and non-invasive adenocarcinoma." Frontiers in Medicine 9 (November 4, 2022). http://dx.doi.org/10.3389/fmed.2022.939434.

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ObjectiveThis study aimed to assess the value of radiomics based on non-contrast computed tomography (NCCT) and contrast-enhanced computed tomography (CECT) images in the preoperative discrimination between lung invasive adenocarcinomas (IAC) and non-invasive adenocarcinomas (non-IAC).MethodsWe enrolled 1,185 pulmonary nodules (478 non-IACs and 707 IACs) to build and validate radiomics models. An external testing set comprising 63 pulmonary nodules was collected to verify the generalization of the models. Radiomic features were extracted from both NCCT and CECT images. The predictive performan

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Hillal, Amir, Gabriella Sultani, Birgitta Ramgren, Bo Norrving, Johan Wassélius, and Teresa Ullberg. "Accuracy of automated intracerebral hemorrhage volume measurement on non-contrast computed tomography: a Swedish Stroke Register cohort study." Neuroradiology, November 3, 2022. http://dx.doi.org/10.1007/s00234-022-03075-9.

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Abstract Purpose Hematoma volume is the strongest predictor of patient outcome after intracerebral hemorrhage (ICH). The aim of this study was to validate novel fully automated software for quantification of ICH volume on non-contrast computed tomography (CT). Methods The population was defined from the Swedish Stroke Register (RS) and included all patients with an ICH diagnosis during 2016–2019 in Region Skåne. Hemorrhage volume on their initial head CT was measured using ABC/2 and manual segmentation (Sectra IDS7 volume measurement tool) and the automated volume quantification tool (qER–NCCT

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Chu, Yue, Gao Ma, Xiao-Quan Xu, et al. "Total and regional ASPECT score for non-contrast CT, CT angiography, and CT perfusion: inter-rater agreement and its association with the final infarction in acute ischemic stroke patients." Acta Radiologica, July 4, 2021, 028418512110290. http://dx.doi.org/10.1177/02841851211029080.

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Background Alberta Stroke Program Early Computed Tomography Score (ASPECTS) is a grading system to assess the extent and distribution of early ischemic changes. Purpose To assess inter-rater agreement for total and regional ASPECTS on non-contrast computed tomography (NCCT) images, CT angiography source images (CTA-SI), and CT-perfusion cerebral blood volume (CTP-CBV) maps, and their association with final infarction in patients with acute ischemic stroke (AIS). Material and Methods A total of 96 consecutive patients with AIS who underwent pre-treatment NCCT and CTP were retrospectively enroll

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Yu, Wei, Chao Xia, Bo Tao, et al. "CT hyperdense lesions after endovascular therapy in acute ischemic stroke: imaging findings and clinical significance." Cerebrovascular Diseases, November 21, 2023. http://dx.doi.org/10.1159/000535369.

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Background The hyperdense lesion on non-contrast CT (NCCT) is a common postoperative phenomenon in acute ischemic stroke (AIS) patients who are treated with endovascular therapy (EVT). Both contrast extravasation and hemorrhagic transformation presented hyperdense lesions on NCCT, which are sometimes difficult to distinguish them. Summary of Review Radiographic findings are important for identifying contrast extravasation and hemorrhagic transformation. We recommended a standardized follow-up protocol involving imaging and clinical evaluation as it will allow neurologists and neuroradiologists

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Payabvash, Seyedmehdi, Mushtaq H. Qureshi, Shahram Majidi, and Adnan I. Qureshi. "Abstract T P34: Residual Contrast Enhancement of Middle Cerebral Artery on Non-contrast Ct (ncct) After Endovascular Treatment in Ischemic Stroke Patients." Stroke 45, suppl_1 (2014). http://dx.doi.org/10.1161/str.45.suppl_1.tp34.

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Background: Residual contrast enhancement of cerebral arteries is frequently visualized on follow up non-contrast CT (NCCT) after endovascular treatment in acute ischemic stroke and may represent distal microvascular no-reflow phenomenon. Objective: To evaluated the prevalence of and correlation between post- endovascular treatment residual contrast enhancement of middle cerebral artery (MCA) on follow up NCCT with clinical and imaging outcomes in patients with acute ischemic stroke. Methods: We analyzed clinical and radiographic data from all patients with acute MCA occlusion who underwent en

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Mortimer, Alex, Richard Flood, Sophie Dunkerton, et al. "Is there a simple and accessible solution to improve acute infarct core imaging? The utility of steady-state CT angiographic source images obtained from a delayed phase acquisition." Interventional Neuroradiology, January 28, 2025. https://doi.org/10.1177/15910199251315790.

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Background Early identification and quantification of core infarct is of importance in stroke management for treatment selection, prognostication, and complication prediction. Non-contrast computed tomography (CT) (NCCT) remains the primary tool, but it suffers from limited sensitivity and inter-rater variability; CT perfusion is inconsistently available and commonly blighted by movement artefact. We assessed the performance of a standardised form of CT angiographic source imaging (CTASI) obtained through addition of a delayed phase at 40 seconds post-contrast injection (DP40) following fast-a

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Li, Qingrun, Feng Li, Hao Liu, et al. "CT-based radiomics models predict spontaneous intracerebral hemorrhage expansion and are comparable with CT angiography spot sign." Frontiers in Neurology 15 (February 26, 2024). http://dx.doi.org/10.3389/fneur.2024.1332509.

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Background and purposeThis study aimed to investigate the efficacy of radiomics, based on non-contrast computed tomography (NCCT) and computed tomography angiography (CTA) images, in predicting early hematoma expansion (HE) in patients with spontaneous intracerebral hemorrhage (SICH). Additionally, the predictive performance of these models was compared with that of the established CTA spot sign.Materials and methodsA retrospective analysis was conducted using CT images from 182 patients with SICH. Data from the patients were divided into a training set (145 cases) and a testing set (37 cases)

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Emde, Julia, Romy Baumgart, Niklas Langguth, Martin Juenemann, and Stefan T. Gerner. "Intravenous thrombolysis in ischemic stroke patients based on non-contrast CT in the extended time-window." Frontiers in Stroke 1 (November 23, 2022). http://dx.doi.org/10.3389/fstro.2022.1026138.

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Purpose of reviewRecent trials provided evidence for safety and efficacy of intravenous thrombolytic therapy (IVT) in ischemic stroke patients beyond the 4.5 h time-window if ischemic penumbra is present in multimodal imaging. However, advanced imaging by either Magnet Resonance Imaging (MRI) or Computed Tomography Perfusion (CTP) is not available 24/7 at most stroke-centers. Therefore, the current review addresses the use of non-contrast CT (NCCT) to identify ischemic stroke patients suitable for IVT in the unknown or extended time-window in terms of efficacy and safety.Recent findingsThe cur

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Payabvash, Seyedmehdi, Mushtaq H. Qureshi, Shayaan M. Khan, Mahnoor Khan, Shahram Majidi, and Adnan I. Qureshi. "Abstract W P45: Differentiation of Contrast Extravasation From Intracranial Hemorrhage on Non-Contrast CT After Endovascular Treatment in Patients With Acute Ischemic Stroke." Stroke 45, suppl_1 (2014). http://dx.doi.org/10.1161/str.45.suppl_1.wp45.

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Background: Distinction of intracranial hemorrhage (ICH) from contrast extravasation after endovascular treatment is crucial for guiding subsequent management in patients with ischemic stroke. We evaluated the imaging characteristics that can help differentiate these two entities on post-endovascular treatment non-contrast CT (NCCT). Methods: Clinical and neuroimaging data for all patients with acute ischemic stroke who underwent endovascular treatment at two medical centers over a 6-year period were reviewed. The first post- endovascular treatment NCCT was evaluated for presence of parenchyma

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Ostman, Cecilia, Carlos Garcia-Esperon, Thomas Lillicrap, et al. "Multimodal Computed Tomography Increases the Detection of Posterior Fossa Strokes Compared to Brain Non-contrast Computed Tomography." Frontiers in Neurology 11 (November 20, 2020). http://dx.doi.org/10.3389/fneur.2020.588064.

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Aims: Multimodal computed tomography (mCT) (non-contrast CT, CT angiography, and CT perfusion) is not routinely used to assess posterior fossa strokes. We described the area under the curve (AUC) of brain NCCT, WB-CTP automated core-penumbra maps and comprehensive CTP analysis (automated core-penumbra maps and all perfusion maps) for posterior fossa strokes.Methods: We included consecutive patients with signs and symptoms of posterior fossa stroke who underwent acute mCT and follow up magnetic resonance diffusion weighted imaging (DWI). Multimodal CT images were reviewed blindly and independen

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Montano, Nataly, Christina Grabarits, Radhika Avadhani, et al. "Abstract 76: Non-Contrast CT Markers and Pre- and Post-Surgical Hematoma Expansion in the MISTIE III Trial Surgical Cohort." Stroke 51, Suppl_1 (2020). http://dx.doi.org/10.1161/str.51.suppl_1.76.

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Introduction: A range of findings on non-contrast CT (NCCT) have been found to predict hematoma expansion after spontaneous ICH, but it is unclear whether these findings predict peri-procedural bleeding. We explored whether any specific NCCT marker(s) predict pre- or post-surgical hematoma expansion events. Methods: NCCTs were reviewed for presence of black hole sign, blend sign, swirl sign, and island sign in the surgical cohort from the MISTIE-III trial which evaluated minimally invasive surgery plus alteplase in ICH >30 mL. Hematoma expansion was defined as any expansion ≥6 mL or 33% ICH

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Fourcand, Farah Y., Abdallah Amireh, Sean Scarpiello, et al. "Abstract Number: LBA8 Thin Cut Non‐Contrast Computed Tomography for Periprocedural Planning: Thrombus Burden Assessment Prior to Mechanical Thrombectomy." Stroke: Vascular and Interventional Neurology 3, S1 (2023). http://dx.doi.org/10.1161/svin.03.suppl_1.lba8.

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Introduction In patients presenting with acute ischemic stroke (AIS), non‐contrast CT (NCCT) and CT angiography (CTA) are used to determine large vessel occlusions (LVO). Using thin‐cut NCCT, hyperdense signs represent thrombus. NCCT provides information on thrombus characteristics such as length and morphology that is not evidenced by CTA. The aim of this study is to determine if hyperdense signs identified on thin‐cut NCCT are a valid tool in periprocedural planning for endovascular thrombectomy (EVT). Methods At our comprehensive stroke center, patients presenting with AIS who had thin‐cut

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Mohapatra, Sulagna, Tsong-Hai Lee, Prasan Kumar Sahoo, and Ching-Yi Wu. "Localization of early infarction on non-contrast CT images in acute ischemic stroke with deep learning approach." Scientific Reports 13, no. 1 (2023). http://dx.doi.org/10.1038/s41598-023-45573-7.

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AbstractLocalization of early infarction on first-line Non-contrast computed tomogram (NCCT) guides prompt treatment to improve stroke outcome. Our previous study has shown a good performance in the identification of ischemic injury on NCCT. In the present study, we developed a deep learning (DL) localization model to help localize the early infarction sign on NCCT. This retrospective study included consecutive 517 ischemic stroke (IS) patients who received NCCT within 12 h after stroke onset. A total of 21,436 infarction patches and 20,391 non-infarction patches were extracted from the slice

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