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Littérature scientifique sur le sujet « Non transcriptional »

Auteur : Grafiati

Publié le 9 mars 2023

Mis à jour le 31 juillet 2025

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Articles de revues sur le sujet "Non transcriptional"

Hokello, Joseph, Adhikarimayum Lakhikumar Sharma, and Mudit Tyagi. "Efficient Non-Epigenetic Activation of HIV Latency through the T-Cell Receptor Signalosome." Viruses 12, no. 8 (2020): 868. http://dx.doi.org/10.3390/v12080868.

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Human immunodeficiency virus type-1 (HIV-1) can either undergo a lytic pathway to cause productive systemic infections or enter a latent state in which the integrated provirus remains transcriptionally silent for decades. The ability to latently infect T-cells enables HIV-1 to establish persistent infections in resting memory CD4+ T-lymphocytes which become reactivated following the disruption or cessation of intensive drug therapy. The maintenance of viral latency occurs through epigenetic and non-epigenetic mechanisms. Epigenetic mechanisms of HIV latency regulation involve the deacetylation

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Ray, J. Christian J., Jeffrey J. Tabor, and Oleg A. Igoshin. "Non-transcriptional regulatory processes shape transcriptional network dynamics." Nature Reviews Microbiology 9, no. 11 (2011): 817–28. http://dx.doi.org/10.1038/nrmicro2667.

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Swami, Meera. "Non-cooperative transcriptional control." Nature Reviews Genetics 11, no. 4 (2010): 240. http://dx.doi.org/10.1038/nrg2768.

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Ježek, Jan, Daniel G. J. Smethurst, David C. Stieg, et al. "Cyclin C: The Story of a Non-Cycling Cyclin." Biology 8, no. 1 (2019): 3. http://dx.doi.org/10.3390/biology8010003.

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The class I cyclin family is a well-studied group of structurally conserved proteins that interact with their associated cyclin-dependent kinases (Cdks) to regulate different stages of cell cycle progression depending on their oscillating expression levels. However, the role of class II cyclins, which primarily act as transcription factors and whose expression remains constant throughout the cell cycle, is less well understood. As a classic example of a transcriptional cyclin, cyclin C forms a regulatory sub-complex with its partner kinase Cdk8 and two accessory subunits Med12 and Med13 called

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O'Gorman, William, Kon Yew Kwek, Benjamin Thomas, and Alexandre Akoulitchev. "Non-coding RNA in transcription initiation." Biochemical Society Symposia 73 (January 1, 2006): 131–40. http://dx.doi.org/10.1042/bss0730131.

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Diverse classes of non-coding RNAs, including snRNAs (small nuclear RNAs), play fundamental regulatory roles in gene expression. For example, 7SK RNA and the components of the splicing apparatus U1–U6 snRNAs are implicated in the regulation of transcriptional elongation. The first evidence for the involvement of RNA in the regulation of transcriptional initiation is now emerging. TFIIH (transcription factor IIH), a general transcription initiation factor, appears to associate specifically with U1 snRNA, a core splicing component. Reconstituted transcription in vitro demonstrates an increase in

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Steensels, Sandra, Jixuan Qiao, and Baran A. Ersoy. "Transcriptional Regulation in Non-Alcoholic Fatty Liver Disease." Metabolites 10, no. 7 (2020): 283. http://dx.doi.org/10.3390/metabo10070283.

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Obesity is the primary risk factor for the pathogenesis of non-alcoholic fatty liver disease (NAFLD), the worldwide prevalence of which continues to increase dramatically. The liver plays a pivotal role in the maintenance of whole-body lipid and glucose homeostasis. This is mainly mediated by the transcriptional activation of hepatic pathways that promote glucose and lipid production or utilization in response to the nutritional state of the body. However, in the setting of chronic excessive nutrition, the dysregulation of hepatic transcriptional machinery promotes lipid accumulation, inflamma

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Poulat, Francis. "Non-Coding Genome, Transcription Factors, and Sex Determination." Sexual Development 15, no. 5-6 (2021): 295–307. http://dx.doi.org/10.1159/000519725.

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In vertebrates, gonadal sex determination is the process by which transcription factors drive the choice between the testicular and ovarian identity of undifferentiated somatic progenitors through activation of 2 different transcriptional programs. Studies in animal models suggest that sex determination always involves sex-specific transcription factors that activate or repress sex-specific genes. These transcription factors control their target genes by recognizing their regulatory elements in the non-coding genome and their binding motifs within their DNA sequence. In the last 20 years, the

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Choi, Yunsik. "Abstract 4140: Non-proteolytic regulation of oncogenic transcription factors by deubiquitinases." Cancer Research 85, no. 8_Supplement_1 (2025): 4140. https://doi.org/10.1158/1538-7445.am2025-4140.

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Abstract Oncogenic transcription factors (TFs) such as ETS2 and TEAD4 are critical regulators of genes driving cancer progression, including those involved in proliferation, survival, and metastasis. Despite their importance, the mechanisms modulating their activity through ubiquitination remain poorly understood. This study investigates deubiquitinases (DUBs) that interact with and regulate ETS2 and TEAD4, aiming to uncover novel insights into their transcriptional control.A DUB sub-library screening identified USP39 and OTUD6A as regulators of ETS2 and TEAD4, respectively. USP39 interacts wi

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Genini, Davide, Ramon Garcia-Escudero, Giuseppina M. Carbone та Carlo V. Catapano. "Transcriptional and Non-Transcriptional Functions of PPARβ/δ in Non-Small Cell Lung Cancer". PLoS ONE 7, № 9 (2012): e46009. http://dx.doi.org/10.1371/journal.pone.0046009.

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Chattopadhyay, Saurabh, Gayatri Subramanian, Ying Zhang, Manoj Veleeparambil, and Ganes C. Sen. "Transcriptional and non-transcriptional functions of IRF3 in host defense." Journal of Immunology 198, no. 1_Supplement (2017): 203.3. http://dx.doi.org/10.4049/jimmunol.198.supp.203.3.

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Abstract Innate immune response is the first line of host defense against microbial infection. Interferon Regulatory Factor 3 (IRF3), a critical transcription factor, is rapidly activated during virus infection to trigger numerous antiviral genes, including the interferons. Our studies have revealed that in addition to triggering these genes, IRF3 activates direct apoptosis of virus-infected cells by a newly discovered antiviral apoptotic pathway, RIPA (Chattopadhyay et al, Immunity 2016, EMBO J, 2010). In RIPA, IRF3 is differentially modified by linear polyubiquitination of two lysine residue

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Thèses sur le sujet "Non transcriptional"

Mayhew, Michael. "Coding regions under non-coding selection: implications for transcriptional and post-transcriptional gene regulation." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=21995.

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The signals that facilitate transcriptional and post-transcriptional gene expression regulation are still being understood. Comparative genomics approaches based on the premise that sequence or structure conservation implies functionality have successfully distinguished true regulatory sequences and structures from prediction noise. Protein-coding regions of genes have often been overlooked as potential regulatory sequence regions. A set of 8785 coding region sequences were previously found to be conserved significantly above a baseline protein-coding conservation level. We call these sequence

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Serra, Barros Ana Cristina. "Transcriptional regulation by non-coding RNAs in Saccharomyces cerevisiae." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:e523d0ee-bb3a-4217-aeba-9e6e398fc86a.

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Genome-wide studies in Saccharomyces cerevisiae have revealed that the majority of the genome is transcribed on both strands, producing both coding and non-coding RNAs (ncRNAs). Initially, these ncRNAs were regarded as spurious transcripts but some have since been shown to have important roles as transcriptional regulators. Very little is understood about how ncRNAs are initiated, terminated and processed or how this influences their function. To address these questions, the expression, stability, and subcellular localization of the ncRNAs at the endogenous GAL locus was analysed. This reveale

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Snead, Aaron Nathan. "Exploring the non-transcriptional activity of thyroid hormone derivatives." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3339205.

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Camilleri, Emily Therese. "The Transcriptional Role of FOXP1 in Non-Hodgkin's Lymphoma." Thesis, Griffith University, 2013. http://hdl.handle.net/10072/367974.

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Non-Hodgkin's lymphoma (NHL) is a family of lymphoid malignances that are the 6th leading cause of death in Australia. B cell lymhomas account for approximately 90% of all NHL cases, and the common subtypes Diffuse Large B cell Lymphoma (DLBCL) and Follicular Lymphoma (FL) together make uo 60% of all cases. DLBCL and FL are both germinal centre derived B cell lymphomas, however these malignancies represent opposite ends of the clinical scale, being aggressive compared to indolent disease respectively. Early detection of lymphoma is highly advantageous for aggressive subtypes like DLBCL, where

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Bogu, Gireesh K. 1984. "Understanding the transcriptional landscape of non-coding genome in mammals." Doctoral thesis, Universitat Pompeu Fabra, 2017. http://hdl.handle.net/10803/572043.

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Widespread transcription in mammals revealed unexpected discovery of non-coding elements like long noncoding RNAs (lncRNAs) and repetitive elements. First, lncRNAs were previously identified in limited number of tissues or cell lines in mouse and the discovery of lncRNAs was still pending in many other tissues in mouse. To address this, we applied a computational pipeline that discovered 2,803 highconfidence novel lncRNAs by mapping and de novo assembling billions of RNA-Seq reads in eight tissues and a primary cell line in mouse. Further, we integrated this catalog of lncRNAs with chro

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POLI, VALENTINA. "A non-transcriptional role of NFAT in regulating platelets functions." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2019. http://hdl.handle.net/10281/241337.

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Le piastrine ricoprono un ruolo fondamentale nei processi di emostasi, ma, recentemente, è stato dimostrato che hanno anche un ruolo nel modulare la risposta infiammatoria, interagendo con le cellule del sistema immunitario in modo diretto e indiretto. Nonostante le piastrine siano delle cellule anucleate, esse contengono fattori trascrizionali (TF) che modulano la loro attivatione attraverso attività non-trascrizionali. In particolare, è stato dimostrato che le piastrine contengono NF-κB, un TF che controlla importanti funzioni delle cellule immunitarie durante i processi infiammatori, e che

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Evans, C. M. "Non-coding RNA and transcriptional regulation in CD4 T cell lineages." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1466165/.

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CD4 T cell lineage choice epitomises the ability of the immune system to become tailored to a specific threat and provides a framework for understanding the mechanisms behind cell specification. The differentiation of T effectors from naïve cells gives rise to pro-inflammatory lineages including T helper 1 (Th1) and Th2 and anti-inflammatory regulatory T cells (Treg). An additional lineage of Treg also exits the thymus in parallel to naïve T cells and together these Treg are required for prevention of autoimmunity. These T cell lineages are distinct in terms of their cytokine production and fu

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Murfitt, Kenneth John. "Post-transcriptional regulation of miRNA activity and expression in C. elegans." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648749.

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Chery, Alicia. "Rôle de la transcription pervasive antisens chez Saccharomyces cerevisiae dans la régulation de l'expression des gènes." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066191/document.

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L'expression des gènes est finement régulée dans la cellule et soumise à de multiples contrôles-qualité. Cette régulation intervient à différents niveaux, de façon à garantir une synthèse efficace des produits fonctionnels de l'expression génique, et pour assurer une adaptation à un changement environnemental. Notamment, les régulations transcriptionnelles sont cruciales pour contrôler la cinétique et le niveau d'expression des gènes. La transcription pervasive est une transcription généralisée non-codante et instable qui fut révélée chez la levure Saccharomyces cerevisiae. Bien que son potent

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Jones, Amy Madeline. "Post-transcriptional regulation of rpoS and HemA in salmonella." Morgantown, W. Va. : [West Virginia University Libraries], 2009. http://hdl.handle.net/10450/10826.

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Livres sur le sujet "Non transcriptional"

Weng, Zhongfu. Dictionnaire pratique chinois-franc̜ais: Avec transcriptions pinyin et zhuyin : caractères simplifiés et non-simplifiés. Librairie You Feng, 2000.

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Salmiņa, Valda. Armēņu īpašvārdu atveide latviešu valodā. LU Latviešu valodas institūts, 2009.

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Stevens, Meredith Leigh. Global repression of non-heat shock gene transcription by activation of heat shock factor in Drosophila. National Library of Canada, 1999.

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George, MacDonald. Lilith ; Lilith A: Transcription of the original manuscript of Lilith. Johannesen, 1994.

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Morrison, Andrew John. Heat shock transcription factors and the hsp70 induction response in neural and non-neural tissues of the hyperthermic rat during postnatal development. National Library of Canada, 2000.

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Cavana, Giovanni Nicolò. Lettere ad Angelico Aprosio (1665-1675). Edited by Luca Tosin. Firenze University Press, 2013. http://dx.doi.org/10.36253/978-88-6655-236-9.

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The critical edition of the correspondence (1665-1675), today housed at the University of Genoa library, between the Genoan patrician Nicolò Cavana and the bibliophile Fra' Angelico Aprosio di Ventimiglia includes an introduction and transcription of the letters, with both bibliographical and (where possible) explanatory notes on some now outdated terms. In consideration of the private nature of the 286 letters, reading them gives an interesting and informal view of seventeenth-century life, as well as much information on the variegated world of the Baroque book culture providing a constant ba

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Pancani, Eleonora, ed. Ruggero Jacobbi alla radio. Firenze University Press, 2008. http://dx.doi.org/10.36253/978-88-8453-664-8.

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Recent years have seen the publication of a great deal of the work of Ruggero Jacobbi, a legendary figure of Italian twentieth-century culture, thanks to a praiseworthy retrieval of unpublished material conserved in the «A. Bonsanti» contemporary archive of the Gabinetto «G.P. Vieusseux». However, despite so many new pages of poetry and translation, what was still lacking was the writer's voice. The voice which, thanks to the painstaking work of Eleonora Pancani, we can now read (if not hear), as with characteristic dexterity it intermingles verses and music, literature and theatre, politics a

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1930-, Sluyser M., ed. Zinc-finger proteins in oncogenesis: DNA-binding and gene regulation. New York Academy of Sciences, 1993.

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Quoss-Moore, Rebecca M. Gender and Position-Taking in Henrician Verse. Amsterdam University Press, 2023. http://dx.doi.org/10.5117/9789463723534.

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Tradition, translation, and transcription in Henrician verse functioned together in systems of communally created, coded position-taking. Understanding this system as an extensive network of production and reception in which women took on many roles allows for new readings of Henrician verse that emphasize the interpretive range available to contemporary reading and writing communities. This restoration demasculinizes our approach to Henrician verse not only through a more equitable consideration of gender’s functions in that social world, but also in de-emphasizing individualized self-fashion

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Dessì, Giuseppe. Diari 1952-1962. Edited by Francesca Nencioni and Franca Linari. Firenze University Press, 2011. http://dx.doi.org/10.36253/978-88-6655-004-4.

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In these private notes, the quest for the self appears like a journey of dual metaphorical significance through the intricate weft of the pages and the labyrinth of life. The Diari 1952-1962 of Giuseppe Dessí are presented here in Franca Linari's meticulous transcription accompanied by an introduction and an attentive commentary by Francesca Nencioni. Following the previous volumes, which made it possible to reconstruct the history of his youthful education and the productions of his early maturity, this one now reveals significant changes in the writer's life. A new female figure (Luisa) acco

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Chapitres de livres sur le sujet "Non transcriptional"

Pandey, Radha Raman, and Chandrasekhar Kanduri. "Transcriptional and Posttranscriptional Programming by Long Noncoding RNAs." In Long Non-Coding RNAs. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-16502-3_1.

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Ebhardt, H. Alexander. "Post-Transcriptional Modifications of Plant Small RNAs." In Non Coding RNAs in Plants. Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-19454-2_4.

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Noy, Noa. "Non-classical Transcriptional Activity of Retinoic Acid." In Subcellular Biochemistry. Springer Netherlands, 2016. http://dx.doi.org/10.1007/978-94-024-0945-1_7.

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Jaiswal, Sharad Kumar, Shivani Singh, and Budhayash Gautam. "Understanding Plant ncRNAs and Transcriptional Gene Regulation in Plant." In Non-coding RNAs for Crop Improvement. Springer Nature Singapore, 2025. https://doi.org/10.1007/978-981-97-7213-1_2.

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Bazzini, Ariel A., and Sebastian Asurmendi. "Effects of Virus Infection on Transcriptional Activity of miR164a in Plants." In Non Coding RNAs in Plants. Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-19454-2_22.

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Aranega, Amelia E., and Diego Franco. "Post-transcriptional Regulation by Proteins and Non-coding RNAs." In Congenital Heart Diseases: The Broken Heart. Springer Vienna, 2016. http://dx.doi.org/10.1007/978-3-7091-1883-2_13.

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Frank, Till D., Miguel A. S. Cavadas, Lan K. Nguyen, and Alex Cheong. "Non-linear Dynamics in Transcriptional Regulation: Biological Logic Gates." In SEMA SIMAI Springer Series. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-33054-9_3.

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Bhan, Arunoday, and Subhrangsu S. Mandal. "Estradiol-Induced Transcriptional Regulation of Long Non-Coding RNA, HOTAIR." In Methods in Molecular Biology. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3127-9_31.

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Mink, Sigrun, Liubov Shatkina, Andrea Nestl, and Andrew C. B. Cato. "Membrane Localization and Rapid Non-Transcriptional Action of the Androgen Receptor." In The Identities of Membrane Steroid Receptors. Springer US, 2003. http://dx.doi.org/10.1007/978-1-4615-0339-2_13.

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Ma, Teng, Jie Zheng, Peng Hao, Xiaohui Zhu, and Xinmei Huang. "The Gene Rearrangement and Transcriptional Regulation of Non B Cell-Derived Immunoglobulin." In Advances in Experimental Medicine and Biology. Springer Nature Singapore, 2024. http://dx.doi.org/10.1007/978-981-97-0511-5_4.

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Actes de conférences sur le sujet "Non transcriptional"

Meng, Jia, Jianqiu Zhang, Yidong Chen, and Yufei Huang. "Bayesian non-negative factor analysis for reconstructing transcriptional regulatory network." In 2011 IEEE Statistical Signal Processing Workshop (SSP). IEEE, 2011. http://dx.doi.org/10.1109/ssp.2011.5967704.

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Rynne, Jennifer, Manuela Plate, Rachel Chambers, Peter Howarth, and Rocio T. Martinez-Nunez. "Post-transcriptional dysregulation as a novel mechanism underlying non-responsive severe asthma." In Abstracts from the 17th ERS Lung Science Conference: ‘Mechanisms of Acute Exacerbation of Respiratory Disease’. European Respiratory Society, 2019. http://dx.doi.org/10.1183/23120541.lungscienceconference-2019.pp208.

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Schaal, Courtney M., Smitha Pillai, Jackie L. Johnson, and Srikumar Chellappan. "Abstract 1803: Transcriptional regulation of nicotinic acetylcholine receptors (nAChRs) by E2F family transcription factors in non-small cell lung cancer." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-1803.

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Asakura, T., H. Dang, K. Okuda, et al. "Spatial Transcriptional Profiling of the Bronchiolectatic Lungs With Non-cystic Fibrosis Bronchiectasis (NCFB)." In American Thoracic Society 2023 International Conference, May 19-24, 2023 - Washington, DC. American Thoracic Society, 2023. http://dx.doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a4239.

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Rynne, Jennifer, Manuela Plate, Rachel Chambers, Peter Howarth, and Rocio T. Martinez-Nunez. "LSC - 2019 - Post-transcriptional dysregulation as a novel mechanism underlying non-responsive severe asthma." In ERS International Congress 2019 abstracts. European Respiratory Society, 2019. http://dx.doi.org/10.1183/13993003.congress-2019.pa2369.

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Razi, Abolfazl, Nilanjana Banerjee, Nevenka Dimitrova, and Vinay Varadan. "Non-linear Bayesian framework to determine the transcriptional effects of cancer-associated genomic aberrations." In 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2015. http://dx.doi.org/10.1109/embc.2015.7319885.

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Bertrams, W., K. Griss, M. Han, et al. "Transcriptional Analysis identifies long non-coding RNAs as potential biomarkers in pneumonia and COPD exacerbation." In 61. Kongress der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin e.V. Georg Thieme Verlag KG, 2020. http://dx.doi.org/10.1055/s-0039-3403105.

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Lu, Tzu-Pin, Pei-Chun Chen, Jang-Ming Lee, et al. "Abstract 2944: Genome-wide transcriptional modulation screening in non-smoking female lung cancer in Taiwan." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-2944.

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Ozes, Ali R., Dave Miller, Cong Guo, Anurag Bhattrai, Yunlong Liu, and Kenneth P. Nephew. "Abstract 5189: The transcriptional regulation of the long non-coding RNA HOTAIR in ovarian cancer." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-5189.

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"Expression of IPD3, a transcriptional regulator of AM symbiosis, affects immunity and flowering time in non-host Arabidopsis." In IS-MPMI Congress. IS-MPMI, 2023. http://dx.doi.org/10.1094/ismpmi-2023-13.

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Arbuscular mycorrhizal symbiosis (AM) is a beneficial trait originating with the first land plants. The ability to host AM has since been lost from diverse plant species. Genes in the Common Symbiosis Pathway that are essential to establish AM hosting were lost from Brassicaceae along with the trait itself, including Interacting Protein of DMI3 (IPD3), a key transcription factor connecting upstream signaling of AM fungal presence to the downstream gene-regulatory network for AM functions. We generated transgenic Arabidopsis plants expressing the DNA-binding domain of IPD3 and used phenotypic a

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Rapports d'organisations sur le sujet "Non transcriptional"

Rafaeli, Ada, and Russell Jurenka. Molecular Characterization of PBAN G-protein Coupled Receptors in Moth Pest Species: Design of Antagonists. United States Department of Agriculture, 2012. http://dx.doi.org/10.32747/2012.7593390.bard.

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The proposed research was directed at determining the activation/binding domains and gene regulation of the PBAN-R’s thereby providing information for the design and screening of potential PBAN-R-blockers and to indicate possible ways of preventing the process from proceeding to its completion. Our specific aims included: (1) The identification of the PBAN-R binding domain by a combination of: (a) in silico modeling studies for identifying specific amino-acid side chains that are likely to be involved in binding PBAN with the receptor and; (b) bioassays to verify the modeling studies using mut

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Amir, Rachel, David J. Oliver, Gad Galili, and Jacline V. Shanks. The Role of Cysteine Partitioning into Glutathione and Methionine Synthesis During Normal and Stress Conditions. United States Department of Agriculture, 2013. http://dx.doi.org/10.32747/2013.7699850.bard.

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The objective of this research is to study the nature of the competition for cysteine (Cys), the first organic sulfur-containing compound, between its two main metabolites, glutathione (GSH) and methionine (Met). GSH plays a central role in protecting plants during various stresses, while Met, an essential amino acid, regulates essential processes and metabolites in plant cells through its metabolite S-adenosyl-Met. Our results, which are based on flux analysis and measurements of Met- metabolites, show that the flux towards Met synthesis is high during non-stress conditions, however the flux

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Sessa, Guido, and Gregory Martin. Role of GRAS Transcription Factors in Tomato Disease Resistance and Basal Defense. United States Department of Agriculture, 2005. http://dx.doi.org/10.32747/2005.7696520.bard.

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The research problem: Bacterial spot and bacterial speck diseases of tomato are causedby strains of Xanthomonas campestris pv. vesicatoria (Xcv) and Pseudomonas syringae pv.tomato (Pst), respectively. These bacteria colonize aerial parts of the plant and causesignificant losses in tomato production worldwide. Protection against Xcv and Pst bycultural practices or chemical control has been unsuccessful and there are only limitedsources of genetic resistance to these pathogens. In previous research supported in part byBARD IS-3237-01, we extensively characterized changes in tomato gene expressio

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Barg, Rivka, Erich Grotewold, and Yechiam Salts. Regulation of Tomato Fruit Development by Interacting MYB Proteins. United States Department of Agriculture, 2012. http://dx.doi.org/10.32747/2012.7592647.bard.

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Background to the topic: Early tomato fruit development is executed via extensive cell divisions followed by cell expansion concomitantly with endoreduplication. The signals involved in activating the different modes of growth during fruit development are still inadequately understood. Addressing this developmental process, we identified SlFSM1 as a gene expressed specifically during the cell-division dependent stages of fruit development. SlFSM1 is the founder of a class of small plant specific proteins containing a divergent SANT/MYB domain (Barg et al 2005). Before initiating this project,

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Dubcovsky, Jorge, Tzion Fahima, Ann Blechl, and Phillip San Miguel. Validation of a candidate gene for increased grain protein content in wheat. United States Department of Agriculture, 2007. http://dx.doi.org/10.32747/2007.7695857.bard.

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High Grain Protein Content (GPC) of wheat is important for improved nutritional value and industrial quality. However, selection for this trait is limited by our poor understanding of the genes involved in the accumulation of protein in the grain. A gene with a large effect on GPC was detected on the short arm of chromosome 6B in a Triticum turgidum ssp. dicoccoides accession from Israel (DIC, hereafter). During the previous BARD project we constructed a half-million clones Bacterial Artificial Chromosome (BAC) library of tetraploid wheat including the high GPC allele from DIC and mapped the G

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Stern, David B., and Gadi Schuster. Manipulation of Gene Expression in the Chloroplast: Control of mRNA Stability and Transcription Termination. United States Department of Agriculture, 1993. http://dx.doi.org/10.32747/1993.7568750.bard.

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Chloroplasts are the site of photosynthesis and of other essential biosynthetic activities in plant cells. Chloroplasts are semi-autonomous organelles, since they contain their own genomes and protein biosynthetic machinery, but depend on the coordinate expression of nuclear genes to assemble macromolecular complexes. The bioeingineering of plants requires manipulation of chloroplast gene expression, and thus a knowledge of the molecular mechanisms that modulate mRNA and protein production. In this proposal the heterotrophic green alga Chlamydomonas reinhardtii has been used as a model system

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Porat, Ron, Gregory T. McCollum, Amnon Lers, and Charles L. Guy. Identification and characterization of genes involved in the acquisition of chilling tolerance in citrus fruit. United States Department of Agriculture, 2007. http://dx.doi.org/10.32747/2007.7587727.bard.

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Citrus, like many other tropical and subtropical fruit are sensitive to chilling temperatures. However, application of a pre-storage temperature conditioning (CD) treatment at 16°C for 7 d or of a hot water brushing (HWB) treatment at 60°C for 20 sec remarkably enhances chilling tolerance and reduces the development of chilling injuries (CI) upon storage at 5°C. In the current research, we proposed to identify and characterize grapefruit genes that are induced by CD, and may contribute to the acquisition of fruit chilling tolerance, by two different molecular approaches: cDNA array analysis an

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Gafni, Yedidya, Moshe Lapidot, and Vitaly Citovsky. Dual role of the TYLCV protein V2 in suppressing the host plant defense. United States Department of Agriculture, 2013. http://dx.doi.org/10.32747/2013.7597935.bard.

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TYLCV-Is is a major tomato pathogen, causing extensive crop losses in Israel and the U.S. We have identified a TYLCV-Is protein, V2, which acts as a suppressor of RNA silencing. Intriguingly, the counter-defense function of V2 may not be limited to silencing suppression. Our recent data suggest that V2 interacts with the tomato CYP1 protease. CYP1 belongs to the family of papain-like cysteine proteases which participate in programmed cell death (PCD) involved in plant defense against pathogens. Based on these data we proposed a model for dual action of V2 in suppressing the host antiviral defe

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Friedman, Haya, Julia Vrebalov, and James Giovannoni. Elucidating the ripening signaling pathway in banana for improved fruit quality, shelf-life and food security. United States Department of Agriculture, 2014. http://dx.doi.org/10.32747/2014.7594401.bard.

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Background : Banana being a monocot and having distinct peel and pulp tissues is unique among the fleshy fruits and hence can provide a more comprehensive understanding of fruit ripening. Our previous research which translated ripening discoveries from tomato, led to the identification of six banana fruit-associated MADS-box genes, and we confirmed the positive role of MaMADS1/2 in banana ripening. The overall goal was to further elucidate the banana ripening signaling pathway as mediated by MADS-boxtranscriptional regulators. Specific objectives were: 1) characterize transcriptional profiles

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Fromm, Hillel, Paul Michael Hasegawa, and Aaron Fait. Calcium-regulated Transcription Factors Mediating Carbon Metabolism in Response to Drought. United States Department of Agriculture, 2013. http://dx.doi.org/10.32747/2013.7699847.bard.

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Original objectives: The long-term goal of the proposed research is to elucidate the transcription factors, genes and metabolic networks involved in carbon metabolism and partitioning in response to water deficit. The proposed research focuses on the GTLcalcium/calmodulinbindingTFs and the gene and metabolic networks modulated by these TFs in Arabidopsis thaliana. The specific objectives are as follows. Objective-1 (USA): Physiological analyses of GTL1 loss- and gain-of-function plants under water sufficient and drought stress conditions Objective 2 (USA / Israel-TAU): Characterizion of GTL ta

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