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Articles de revues sur le sujet « Non transcriptional »

Auteur : Grafiati

Publié le 9 mars 2023

Mis à jour le 31 juillet 2025

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1

Hokello, Joseph, Adhikarimayum Lakhikumar Sharma, and Mudit Tyagi. "Efficient Non-Epigenetic Activation of HIV Latency through the T-Cell Receptor Signalosome." Viruses 12, no. 8 (2020): 868. http://dx.doi.org/10.3390/v12080868.

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Human immunodeficiency virus type-1 (HIV-1) can either undergo a lytic pathway to cause productive systemic infections or enter a latent state in which the integrated provirus remains transcriptionally silent for decades. The ability to latently infect T-cells enables HIV-1 to establish persistent infections in resting memory CD4+ T-lymphocytes which become reactivated following the disruption or cessation of intensive drug therapy. The maintenance of viral latency occurs through epigenetic and non-epigenetic mechanisms. Epigenetic mechanisms of HIV latency regulation involve the deacetylation

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Ray, J. Christian J., Jeffrey J. Tabor, and Oleg A. Igoshin. "Non-transcriptional regulatory processes shape transcriptional network dynamics." Nature Reviews Microbiology 9, no. 11 (2011): 817–28. http://dx.doi.org/10.1038/nrmicro2667.

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Swami, Meera. "Non-cooperative transcriptional control." Nature Reviews Genetics 11, no. 4 (2010): 240. http://dx.doi.org/10.1038/nrg2768.

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Ježek, Jan, Daniel G. J. Smethurst, David C. Stieg, et al. "Cyclin C: The Story of a Non-Cycling Cyclin." Biology 8, no. 1 (2019): 3. http://dx.doi.org/10.3390/biology8010003.

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The class I cyclin family is a well-studied group of structurally conserved proteins that interact with their associated cyclin-dependent kinases (Cdks) to regulate different stages of cell cycle progression depending on their oscillating expression levels. However, the role of class II cyclins, which primarily act as transcription factors and whose expression remains constant throughout the cell cycle, is less well understood. As a classic example of a transcriptional cyclin, cyclin C forms a regulatory sub-complex with its partner kinase Cdk8 and two accessory subunits Med12 and Med13 called

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O'Gorman, William, Kon Yew Kwek, Benjamin Thomas, and Alexandre Akoulitchev. "Non-coding RNA in transcription initiation." Biochemical Society Symposia 73 (January 1, 2006): 131–40. http://dx.doi.org/10.1042/bss0730131.

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Diverse classes of non-coding RNAs, including snRNAs (small nuclear RNAs), play fundamental regulatory roles in gene expression. For example, 7SK RNA and the components of the splicing apparatus U1–U6 snRNAs are implicated in the regulation of transcriptional elongation. The first evidence for the involvement of RNA in the regulation of transcriptional initiation is now emerging. TFIIH (transcription factor IIH), a general transcription initiation factor, appears to associate specifically with U1 snRNA, a core splicing component. Reconstituted transcription in vitro demonstrates an increase in

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Steensels, Sandra, Jixuan Qiao, and Baran A. Ersoy. "Transcriptional Regulation in Non-Alcoholic Fatty Liver Disease." Metabolites 10, no. 7 (2020): 283. http://dx.doi.org/10.3390/metabo10070283.

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Obesity is the primary risk factor for the pathogenesis of non-alcoholic fatty liver disease (NAFLD), the worldwide prevalence of which continues to increase dramatically. The liver plays a pivotal role in the maintenance of whole-body lipid and glucose homeostasis. This is mainly mediated by the transcriptional activation of hepatic pathways that promote glucose and lipid production or utilization in response to the nutritional state of the body. However, in the setting of chronic excessive nutrition, the dysregulation of hepatic transcriptional machinery promotes lipid accumulation, inflamma

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Poulat, Francis. "Non-Coding Genome, Transcription Factors, and Sex Determination." Sexual Development 15, no. 5-6 (2021): 295–307. http://dx.doi.org/10.1159/000519725.

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In vertebrates, gonadal sex determination is the process by which transcription factors drive the choice between the testicular and ovarian identity of undifferentiated somatic progenitors through activation of 2 different transcriptional programs. Studies in animal models suggest that sex determination always involves sex-specific transcription factors that activate or repress sex-specific genes. These transcription factors control their target genes by recognizing their regulatory elements in the non-coding genome and their binding motifs within their DNA sequence. In the last 20 years, the

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Choi, Yunsik. "Abstract 4140: Non-proteolytic regulation of oncogenic transcription factors by deubiquitinases." Cancer Research 85, no. 8_Supplement_1 (2025): 4140. https://doi.org/10.1158/1538-7445.am2025-4140.

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Abstract Oncogenic transcription factors (TFs) such as ETS2 and TEAD4 are critical regulators of genes driving cancer progression, including those involved in proliferation, survival, and metastasis. Despite their importance, the mechanisms modulating their activity through ubiquitination remain poorly understood. This study investigates deubiquitinases (DUBs) that interact with and regulate ETS2 and TEAD4, aiming to uncover novel insights into their transcriptional control.A DUB sub-library screening identified USP39 and OTUD6A as regulators of ETS2 and TEAD4, respectively. USP39 interacts wi

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Genini, Davide, Ramon Garcia-Escudero, Giuseppina M. Carbone та Carlo V. Catapano. "Transcriptional and Non-Transcriptional Functions of PPARβ/δ in Non-Small Cell Lung Cancer". PLoS ONE 7, № 9 (2012): e46009. http://dx.doi.org/10.1371/journal.pone.0046009.

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Chattopadhyay, Saurabh, Gayatri Subramanian, Ying Zhang, Manoj Veleeparambil, and Ganes C. Sen. "Transcriptional and non-transcriptional functions of IRF3 in host defense." Journal of Immunology 198, no. 1_Supplement (2017): 203.3. http://dx.doi.org/10.4049/jimmunol.198.supp.203.3.

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Abstract Innate immune response is the first line of host defense against microbial infection. Interferon Regulatory Factor 3 (IRF3), a critical transcription factor, is rapidly activated during virus infection to trigger numerous antiviral genes, including the interferons. Our studies have revealed that in addition to triggering these genes, IRF3 activates direct apoptosis of virus-infected cells by a newly discovered antiviral apoptotic pathway, RIPA (Chattopadhyay et al, Immunity 2016, EMBO J, 2010). In RIPA, IRF3 is differentially modified by linear polyubiquitination of two lysine residue

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Bouget, François-Yves, Marc Lefranc, Quentin Thommen, et al. "Transcriptional versus non-transcriptional clocks: A case study in Ostreococcus." Marine Genomics 14 (April 2014): 17–22. http://dx.doi.org/10.1016/j.margen.2014.01.004.

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Carvalho Barbosa, Cristina, Sydnee H. Calhoun, and Hans-Joachim Wieden. "Non-coding RNAs: what are we missing?" Biochemistry and Cell Biology 98, no. 1 (2020): 23–30. http://dx.doi.org/10.1139/bcb-2019-0037.

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Over the past two decades, the importance of small non-coding RNAs (sncRNAs) as regulatory molecules has become apparent in all three domains of life (archaea, bacteria, eukaryotes). In fact, sncRNAs play an important role in the control of gene expression at both the transcriptional and the post-transcriptional level, with crucial roles in fine-tuning cell responses during internal and external stress. Multiple pathways for sncRNA biogenesis and diverse mechanisms of regulation have been reported, and although biogenesis and mechanisms of sncRNAs in prokaryotes and eukaryotes are different, r

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Ali, Amjad, Ritu Mishra, Harsimrut Kaur, and Akhil Chandra Banerjea. "HIV-1 Tat: An update on transcriptional and non-transcriptional functions." Biochimie 190 (November 2021): 24–35. http://dx.doi.org/10.1016/j.biochi.2021.07.001.

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Dykes, Iain M., and Costanza Emanueli. "Transcriptional and Post-transcriptional Gene Regulation by Long Non-coding RNA." Genomics, Proteomics & Bioinformatics 15, no. 3 (2017): 177–86. http://dx.doi.org/10.1016/j.gpb.2016.12.005.

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Vale, Mariana, Hélder Badim, Hernâni Gerós, and Artur Conde. "Non-Mature miRNA-Encoded Micropeptide miPEP166c Stimulates Anthocyanin and Proanthocyanidin Synthesis in Grape Berry Cells." International Journal of Molecular Sciences 25, no. 3 (2024): 1539. http://dx.doi.org/10.3390/ijms25031539.

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The phenylpropanoid and flavonoid pathways exhibit intricate regulation, not only influenced by environmental factors and a complex network of transcription factors but also by post-transcriptional regulation, such as silencing by microRNAs and miRNA-encoded micropeptides (miPEPs). VviMYBC2-L1 serves as a transcriptional repressor for flavonoids, playing a crucial role in coordinating the synthesis of anthocyanin and proanthocyanidin. It works in tandem with their respective transcriptional activators, VviMYBA1/2 and VviMYBPA1, to maintain an equilibrium of flavonoids. We have discovered a miP

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van Ooijen, Gerben, and Andrew J. Millar. "Non-transcriptional oscillators in circadian timekeeping." Trends in Biochemical Sciences 37, no. 11 (2012): 484–92. http://dx.doi.org/10.1016/j.tibs.2012.07.006.

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Chen, Yung-Chia Ariel, and Alexei A. Aravin. "Non-coding RNAs in Transcriptional Regulation." Current Molecular Biology Reports 1, no. 1 (2015): 10–18. http://dx.doi.org/10.1007/s40610-015-0002-6.

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Lozano-Velasco, Estefanía, Carlos Garcia-Padilla, Miguel Carmona-Garcia, et al. "MEF2C Directly Interacts with Pre-miRNAs and Distinct RNPs to Post-Transcriptionally Regulate miR-23a-miR-27a-miR-24-2 microRNA Cluster Member Expression." Non-Coding RNA 10, no. 3 (2024): 32. http://dx.doi.org/10.3390/ncrna10030032.

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Transcriptional regulation constitutes a key step in gene expression regulation. Myocyte enhancer factor 2C (MEF2C) is a transcription factor of the MADS box family involved in the early development of several cell types, including muscle cells. Over the last decade, a novel layer of complexity modulating gene regulation has emerged as non-coding RNAs have been identified, impacting both transcriptional and post-transcriptional regulation. microRNAs represent the most studied and abundantly expressed subtype of small non-coding RNAs, and their functional roles have been widely documented. On t

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Sadka, Avi, Qiaoping Qin, Jianrong Feng, et al. "Ethylene Response of Plum ACC Synthase 1 (ACS1) Promoter is Mediated through the Binding Site of Abscisic Acid Insensitive 5 (ABI5)." Plants 8, no. 5 (2019): 117. http://dx.doi.org/10.3390/plants8050117.

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The enzyme 1-amino-cyclopropane-1-carboxylic acid synthase (ACS) participates in the ethylene biosynthesis pathways and it is tightly regulated transcriptionally and post-translationally. Notwithstanding its major role in climacteric fruit ripening, the transcriptional regulation of ACS during ripening is not fully understood. We studied fruit ripening in two Japanese plum cultivars, the climacteric Santa Rosa (SR) and its non-climacteric bud sport mutant, Sweet Miriam (SM). As the two cultivars show considerable difference in ACS expression, they provide a good system for the study of the tra

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Buist, Marjorie, David Fuss, and Mojgan Rastegar. "Transcriptional Regulation of MECP2E1-E2 Isoforms and BDNF by Metformin and Simvastatin through Analyzing Nascent RNA Synthesis in a Human Brain Cell Line." Biomolecules 11, no. 8 (2021): 1253. http://dx.doi.org/10.3390/biom11081253.

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Methyl CpG binding protein 2 (MeCP2) is the main DNA methyl-binding protein in the brain that binds to 5-methylcytosine and 5-hydroxymethyl cytosine. MECP2 gene mutations are the main origin of Rett Syndrome (RTT), a neurodevelopmental disorder in young females. The disease has no existing cure, however, metabolic drugs such as metformin and statins have recently emerged as potential therapeutic candidates. In addition, induced MECP2-BDNF homeostasis regulation has been suggested as a therapy avenue. Here, we analyzed nascent RNA synthesis versus steady state total cellular RNA to study the tr

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Groh, Matthias, Lara Marques Silva, and Natalia Gromak. "Mechanisms of transcriptional dysregulation in repeat expansion disorders." Biochemical Society Transactions 42, no. 4 (2014): 1123–28. http://dx.doi.org/10.1042/bst20140049.

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Approximately 40 human diseases are associated with expansion of repeat sequences. These expansions can reside within coding or non-coding parts of the genes, affecting the host gene function. The presence of such expansions results in the production of toxic RNA and/or protein or causes transcriptional repression and silencing of the host gene. Although the molecular mechanisms of expansion diseases are not well understood, mounting evidence suggests that transcription through expanded repeats plays an essential role in disease pathology. The presence of an expansion can affect RNA polymerase

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Azuma, Kotaro, and Satoshi Inoue. "Genomic and non-genomic actions of estrogen: recent developments." BioMolecular Concepts 3, no. 4 (2012): 365–70. http://dx.doi.org/10.1515/bmc-2012-0002.

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AbstractEstrogen affects transcriptional status by activating its corresponding nuclear receptor, the estrogen receptor (ER). It can also induce rapid cellular reactions within a few minutes, and this feature cannot be explained by the transcription-mediated effects of estrogen. The latter mechanisms are called ‘non-genomic actions’ of estrogen. In contrast, the former classic modes of action came to be called ‘genomic actions’. One of the recent developments of research on estrogen was the substantiation of the non-genomic actions of estrogen; these were initially observed and reported as int

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Xu, Jun, Jenny Chong, and Dong Wang. "Strand-specific effect of Rad26 and TFIIS in rescuing transcriptional arrest by CAG trinucleotide repeat slip-outs." Nucleic Acids Research 49, no. 13 (2021): 7618–27. http://dx.doi.org/10.1093/nar/gkab573.

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Abstract Transcription induced CAG repeat instability is associated with fatal neurological disorders. Genetic approaches found transcription-coupled nucleotide excision repair (TC-NER) factor CSB protein and TFIIS play critical roles in modulating the repeat stability. Here, we took advantage of an in vitro reconstituted yeast transcription system to investigate the underlying mechanism of RNA polymerase II (Pol II) transcriptional pausing/stalling by CAG slip-out structures and the functions of TFIIS and Rad26, the yeast ortholog of CSB, in modulating transcriptional arrest. We identified le

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Sen, Rwik, Shivani Malik, Sarah Frankland-Searby, Bhawana Uprety, Shweta Lahudkar, and Sukesh R. Bhaumik. "Rrd1p, an RNA polymerase II-specific prolyl isomerase and activator of phosphoprotein phosphatase, promotes transcription independently of rapamycin response." Nucleic Acids Research 42, no. 15 (2014): 9892–907. http://dx.doi.org/10.1093/nar/gku703.

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Abstract Rrd1p (resistance to rapamycin deletion 1) has been previously implicated in controlling transcription of rapamycin-regulated genes in response to rapamycin treatment. Intriguingly, we show here that Rrd1p associates with the coding sequence of a galactose-inducible and rapamycin non-responsive GAL1 gene, and promotes the association of RNA polymerase II with GAL1 in the absence of rapamycin treatment following transcriptional induction. Consistently, nucleosomal disassembly at GAL1 is impaired in the absence of Rrd1p, and GAL1 transcription is reduced in the Δrrd1 strain. Likewise, R

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Jang, Sang-Min, Joo-Hee An, Chul-Hong Kim, Jung-Woong Kim, and Kyung-Hee Choi. "Transcription factor FOXA2-centered transcriptional regulation network in non-small cell lung cancer." Biochemical and Biophysical Research Communications 463, no. 4 (2015): 961–67. http://dx.doi.org/10.1016/j.bbrc.2015.06.042.

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O’Callaghan, Chris, Da Lin, and Thomas K. Hiron. "Intragenic transcriptional interference regulates the human immune ligand MICA." Journal of Immunology 200, no. 1_Supplement (2018): 109.23. http://dx.doi.org/10.4049/jimmunol.200.supp.109.23.

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Abstract Regulation of MICA expression is incompletely understood, but human MICA can be upregulated in cancer cells, virus-infected cells and rapidly proliferating cells. Binding of MICA to the activating NKG2D receptor on cytotoxic immune cells promotes elimination of the cell expressing MICA. We noted that MICA has tandem promoters that drive overlapping forward transcription. We show that the MICA gene contains a conserved upstream promoter that expresses a non coding transcript. Transcription from the upstream promoter represses transcription from the standard downstream MICA promoter in

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Li, Yakun, Lihong Ding, Mei Zhou, Zhixiang Chen, Yanfei Ding, and Cheng Zhu. "Transcriptional Regulatory Network of Plant Cadmium Stress Response." International Journal of Molecular Sciences 24, no. 5 (2023): 4378. http://dx.doi.org/10.3390/ijms24054378.

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Cadmium (Cd) is a non-essential heavy metal with high toxicity to plants. Plants have acquired specialized mechanisms to sense, transport, and detoxify Cd. Recent studies have identified many transporters involved in Cd uptake, transport, and detoxification. However, the complex transcriptional regulatory networks involved in Cd response remain to be elucidated. Here, we provide an overview of current knowledge regarding transcriptional regulatory networks and post-translational regulation of the transcription factors involved in Cd response. An increasing number of reports indicate that epige

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Mazina, Marina Yu, and Nadezhda E. Vorobyeva. "Chromatin Modifiers in Transcriptional Regulation: New Findings and Prospects." Acta Naturae 13, no. 1 (2021): 16–30. http://dx.doi.org/10.32607/actanaturae.11101.

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Histone-modifying and remodeling complexes are considered the main coregulators that affect transcription by changing the chromatin structure. Coordinated action by these complexes is essential for the transcriptional activation of any eukaryotic gene. In this review, we discuss current trends in the study of histone modifiers and chromatin remodelers, including the functional impact of transcriptional proteins/complexes i.e., pioneers; remodeling and modification of non-histone proteins by transcriptional complexes; the supplementary functions of the non-catalytic subunits of remodelers, and

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Hernández-Lemus, Enrique, and María D. Correa-Rodríguez. "Non-Equilibrium Hyperbolic Transport in Transcriptional Regulation." PLoS ONE 6, no. 7 (2011): e21558. http://dx.doi.org/10.1371/journal.pone.0021558.

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Barrandon, Charlotte, Béatrice Spiluttini, and Olivier Bensaude. "Non-coding RNAs regulating the transcriptional machinery." Biology of the Cell 100, no. 2 (2008): 83–95. http://dx.doi.org/10.1042/bc20070090.

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Feng, Yan-Ling, Jian-Min Dong, and Xu-Lei Tang. "Non-Markovian Effect on Gene Transcriptional Systems." Chinese Physics Letters 33, no. 10 (2016): 108701. http://dx.doi.org/10.1088/0256-307x/33/10/108701.

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Strähle, Uwe, and Sepand Rastegar. "Conserved non-coding sequences and transcriptional regulation." Brain Research Bulletin 75, no. 2-4 (2008): 225–30. http://dx.doi.org/10.1016/j.brainresbull.2007.11.010.

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Wong, David CS, and John S. O’Neill. "Non-transcriptional processes in circadian rhythm generation." Current Opinion in Physiology 5 (October 2018): 117–32. http://dx.doi.org/10.1016/j.cophys.2018.10.003.

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Kanai, K., and K. Kataoka. "P128. Phosphorylations regulate transcriptional and non-transcriptional activity of MafA in oncogenic transformation." Differentiation 80 (November 2010): S60. http://dx.doi.org/10.1016/j.diff.2010.09.134.

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Simoncini, T., and AR Genazzani. "Non-genomic actions of sex steroid hormones." European Journal of Endocrinology 148, no. 3 (2003): 281–92. http://dx.doi.org/10.1530/eje.0.1480281.

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Steroid hormone receptors have been traditionally considered to act via the regulation of transcriptional processes, involving nuclear translocation and binding to specific response elements, and ultimately leading to regulation of gene expression. However, novel non-transcriptional mechanisms of signal transduction through steroid hormone receptors have been identified. These so-called 'non-genomic' effects do not depend on gene transcription or protein synthesis and involve steroid-induced modulation of cytoplasmic or cell membrane-bound regulatory proteins. Several relevant biological actio

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Escher, Felicitas, Ganna Aleshcheva, Heiko Pietsch, et al. "Transcriptional Active Parvovirus B19 Infection Predicts Adverse Long-Term Outcome in Patients with Non-Ischemic Cardiomyopathy." Biomedicines 9, no. 12 (2021): 1898. http://dx.doi.org/10.3390/biomedicines9121898.

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Parvovirus B19 (B19V) is the predominant cardiotropic virus currently found in endomyocardial biopsies (EMBs). However, direct evidence showing a causal relationship between B19V and progression of inflammatory cardiomyopathy are still missing. The aim of this study was to analyze the impact of transcriptionally active cardiotropic B19V infection determined by viral RNA expression upon long-term outcomes in a large cohort of adult patients with non-ischemic cardiomyopathy in a retrospective analysis from a prospective observational cohort. In total, the analyzed study group comprised 871 conse

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LI, Yuting, Huan HAN, Jiabao YE, Feng XU, Weiwei ZHANG, and Yongling LIAO. "Regulation mechanism of long non-coding RNA in plant secondary metabolite biosynthesis." Notulae Botanicae Horti Agrobotanici Cluj-Napoca 50, no. 2 (2022): 12604. http://dx.doi.org/10.15835/nbha50212604.

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Long non-coding RNAs (lncRNAs) are widely available transcription products of more than 200 nucleotides with unrecognizable coding potential. A large number of lncRNAs have been identified in different plants. lncRNAs are involved in various basic biological processes at the transcriptional, post-transcriptional and epigenetic levels as key regulatory molecules, including in the regulation of flowering time and reproductive organ morphogenesis, and they play important roles in the biosynthesis of plant secondary metabolites. In this paper, we review the research strategies of lncRNAs and lncRN

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Borczyk, Malgorzata, Mateusz Zieba, Michał Korostyński, and Marcin Piechota. "Role of Non-Coding Regulatory Elements in the Control of GR-Dependent Gene Expression." International Journal of Molecular Sciences 22, no. 8 (2021): 4258. http://dx.doi.org/10.3390/ijms22084258.

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The glucocorticoid receptor (GR, also known as NR3C1) coordinates molecular responses to stress. It is a potent transcription activator and repressor that influences hundreds of genes. Enhancers are non-coding DNA regions outside of the core promoters that increase transcriptional activity via long-distance interactions. Active GR binds to pre-existing enhancer sites and recruits further factors, including EP300, a known transcriptional coactivator. However, it is not known how the timing of GR-binding-induced enhancer remodeling relates to transcriptional changes. Here we analyze data from th

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Truong, Dong-Jiunn Jeffery, Niklas Armbrust, Julian Geilenkeuser, et al. "Intron-encoded cistronic transcripts for minimally invasive monitoring of coding and non-coding RNAs." Nature Cell Biology 24, no. 11 (2022): 1666–76. http://dx.doi.org/10.1038/s41556-022-00998-6.

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AbstractDespite their fundamental role in assessing (patho)physiological cell states, conventional gene reporters can follow gene expression but leave scars on the proteins or substantially alter the mature messenger RNA. Multi-time-point measurements of non-coding RNAs are currently impossible without modifying their nucleotide sequence, which can alter their native function, half-life and localization. Thus, we developed the intron-encoded scarless programmable extranuclear cistronic transcript (INSPECT) as a minimally invasive transcriptional reporter embedded within an intron of a gene of

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Cao, Zhengyue, Tiantian Wang, Fumin Tai, et al. "Long Non-Coding RNA LOC401312 Induces Radiosensitivity Through Upregulation of CPS1 in Non-Small Cell Lung Cancer." International Journal of Molecular Sciences 26, no. 12 (2025): 5865. https://doi.org/10.3390/ijms26125865.

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Long noncoding RNAs (lncRNAs), non-protein-coding transcripts exceeding 200 nucleotides, are critical regulators of gene expression through chromatin remodeling, transcriptional modulation, and post-transcriptional modifications. While ionizing radiation (IR) induces cellular damage through direct DNA breaks, reactive oxygen species (ROS)-mediated oxidative stress, and bystander effects, the functional involvement of lncRNAs in the radiation response remains incompletely characterized. Here, through genome-wide CRISPR activation (CRISPRa) screening in non-small cell lung cancer (NSCLC) cells,

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Ma, Qiuqin, Shihui Long, Zhending Gan, Gianluca Tettamanti, Kang Li, and Ling Tian. "Transcriptional and Post-Transcriptional Regulation of Autophagy." Cells 11, no. 3 (2022): 441. http://dx.doi.org/10.3390/cells11030441.

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Autophagy is a widely conserved process in eukaryotes that is involved in a series of physiological and pathological events, including development, immunity, neurodegenerative disease, and tumorigenesis. It is regulated by nutrient deprivation, energy stress, and other unfavorable conditions through multiple pathways. In general, autophagy is synergistically governed at the RNA and protein levels. The upstream transcription factors trigger or inhibit the expression of autophagy- or lysosome-related genes to facilitate or reduce autophagy. Moreover, a significant number of non-coding RNAs (micr

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Müller, Andreas, Patrick Weyerhäuser, Nancy Berte, et al. "Concurrent Activation of Both Survival-Promoting and Death-Inducing Signaling by Chloroquine in Glioblastoma Stem Cells: Implications for Potential Risks and Benefits of Using Chloroquine as Radiosensitizer." Cells 12, no. 9 (2023): 1290. http://dx.doi.org/10.3390/cells12091290.

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Lysosomotropic agent chloroquine was shown to sensitize non-stem glioblastoma cells to radiation in vitro with p53-dependent apoptosis implicated as one of the underlying mechanisms. The in vivo outcomes of chloroquine or its effects on glioblastoma stem cells have not been previously addressed. This study undertakes a combinatorial approach encompassing in vitro, in vivo and in silico investigations to address the relationship between chloroquine-mediated radiosensitization and p53 status in glioblastoma stem cells. Our findings reveal that chloroquine elicits antagonistic impacts on signalin

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Chandana, B. S. 1* And Ramachandra V. 2. "Gene silencing by small RNAs in plants." Science World a monthly e magazine 2, no. 12 (2022): 2110–12. https://doi.org/10.5281/zenodo.7429353.

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The phenomenon of gene silencing by small non-coding RNAs, i.e., small interfering RNA (siRNA) and microRNA (miRNA) has becoming as one of potential approaches for crop improvement. Gene silencing is generally defined as an epigenetic modification of gene expression leading to inactivation of previously active individual genes or larger chromosome regions. Gene silencing can also occur post transcriptionally due to mRNA degradation and/or repression of its translation. These effects are often mediated by small RNA regulators such as small interfering RNAS (siRNAs), microRNAs (miRNAs) which are

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Taylor, Samuel, Jacob Stauber, Oliver Bohorquez, et al. "Transcription Factor Redistributors Pharmacologically Actuate Non-Canonical Gene Networks to Drive AML Differentiation." Blood 142, Supplement 1 (2023): 119. http://dx.doi.org/10.1182/blood-2023-186698.

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Aberrant transcriptional networks are hallmarks of aging and cancer, yet our ability to target these aberrations is poor. PU.1 is one such transcription factor (TF) who's transcriptional networks are corrupted in disease, including in &gt;50% of Acute Myeloid Leukemia (AML) cases. In this study we investigate an unappreciated pharmacological approach to target the aberrant PU.1 network, by employing novel small molecules which competitively inhibit PU.1:DNA interactions. We performed an extensive multiomics-driven, molecular characterization of AML cells following exposure to PU.1-DNA bind

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Inazumi, Hideaki, and Koichiro Kuwahara. "NRSF/REST-Mediated Epigenomic Regulation in the Heart: Transcriptional Control of Natriuretic Peptides and Beyond." Biology 11, no. 8 (2022): 1197. http://dx.doi.org/10.3390/biology11081197.

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Reactivation of fetal cardiac genes, including those encoding atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), is a key feature of pathological cardiac remodeling and heart failure. Intensive studies on the regulation of ANP and BNP have revealed the involvement of numerous transcriptional factors in the regulation of the fetal cardiac gene program. Among these, we identified that a transcriptional repressor, neuron-restrictive silencer factor (NRSF), also named repressor element-1-silencing transcription factor (REST), which was initially detected as a transcriptional rep

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Maldonado, Edio, Sebastian Morales-Pison, Fabiola Urbina, Lilian Jara, and Aldo Solari. "Role of the Mediator Complex and MicroRNAs in Breast Cancer Etiology." Genes 13, no. 2 (2022): 234. http://dx.doi.org/10.3390/genes13020234.

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Transcriptional coactivators play a key role in RNA polymerase II transcription and gene regulation. One of the most important transcriptional coactivators is the Mediator (MED) complex, which is an evolutionary conserved large multiprotein complex. MED transduces the signal between DNA-bound transcriptional activators (gene-specific transcription factors) to the RNA polymerase II transcription machinery to activate transcription. It is known that MED plays an essential role in ER-mediated gene expression mainly through the MED1 subunit, since estrogen receptor (ER) can interact with MED1 by s

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Chowdhury, Moumita Roy, Jolly Basak, and Ranjit Prasad Bahadur. "Elucidating the Functional Role of Predicted miRNAs in Post- Transcriptional Gene Regulation Along with Symbiosis in Medicago truncatula." Current Bioinformatics 15, no. 2 (2020): 108–20. http://dx.doi.org/10.2174/1574893614666191003114202.

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Background: microRNAs are small non-coding RNAs which inhibit translational and post-transcriptional processes whereas long non-coding RNAs are found to regulate both transcriptional and post-transcriptional gene expression. Medicago truncatula is a well-known model plant for studying legume biology and is also used as a forage crop. In spite of its importance in nitrogen fixation and soil fertility improvement, little information is available about Medicago non-coding RNAs that play important role in symbiosis. Objective: In this study we have tried to understand the role of Medicago ncRNAs i

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Peng, Weidan, Lauren Merlo, and Laura Mandik-Nayak. "IDO2 mediates inflammatory responses through both enzymatic and non-enzymatic mechanisms." Journal of Immunology 212, no. 1_Supplement (2024): 1366_4424. http://dx.doi.org/10.4049/jimmunol.212.supp.1366.4424.

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Abstract The tryptophan catabolizing enzymes indoleamine-2,3-dioxygenase (IDO)1 and IDO2 play important immune modulatory roles in development of inflammation and tolerance. In contrast to the immune regulatory function described for IDO1, IDO2 is a proinflammatory modifier of disease in models of autoimmune arthritis and contact hypersensitivity. Using catalytically inactive IDO2 knock-in mice, we found that the enzymatic function of IDO2 was required to mediate inflammation in contact hypersensitivity but was not required for the development of autoimmunity, suggesting IDO2 acts through both

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Shliakhtunou, Yauheni A., Valery M. Siamionau, and Vyacheslau V. Pobyarzhin. "Transcription phenotype of circulating tumor cells in non-metastatic breast cancer." Carcinogenesis 43, no. 1 (2021): 21–27. http://dx.doi.org/10.1093/carcin/bgab112.

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Abstract The presented research is relevant, as breast cancer is the most commonly diagnosed cancer in the female population worldwide, with the exception of skin cancer. The aim of this article is to study the transcription phenotype of circulating tumor cells in non-metastatic breast cancer. The transcriptional phenotype of circulating tumor cells (CTCs) was studied using real-time polymerase chain reaction (PCR). Three-year OS was 79.2, and 90.8 without the expression with p Log-Rank = 0.04. Independent prognostic factors for the recurrence of disease include the presence of CTCs expressing

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Ibragimov, Airat N., Oleg V. Bylino, and Yulii V. Shidlovskii. "Molecular Basis of the Function of Transcriptional Enhancers." Cells 9, no. 7 (2020): 1620. http://dx.doi.org/10.3390/cells9071620.

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Transcriptional enhancers are major genomic elements that control gene activity in eukaryotes. Recent studies provided deeper insight into the temporal and spatial organization of transcription in the nucleus, the role of non-coding RNAs in the process, and the epigenetic control of gene expression. Thus, multiple molecular details of enhancer functioning were revealed. Here, we describe the recent data and models of molecular organization of enhancer-driven transcription.

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