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1

Cuadrado, María-Luz. "Epicranial headaches part 2: Nummular headache and epicrania fugax." Cephalalgia 43, no. 4 (2023): 033310242211469. http://dx.doi.org/10.1177/03331024221146976.

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Background Nummular headache and epicrania fugax are two primary headaches that fall under the heading of epicranial headaches. Methods This article reviews the epidemiological and clinical features of nummular headache and epicrania fugax, proposed pathogenic mechanisms and state-of-the-art management, according to the literature. Results and conclusions Nummular headache and epicrania fugax are generally viewed as rare headache disorders, but no population-based epidemiological data are available. Nummular headache is characterized by continuous or intermittent head pain, which remains circu
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Martins, Isabel Pavão, and Luis Abreu. "Nummular headache." Cephalalgia Reports 1 (January 1, 2018): 251581631880277. http://dx.doi.org/10.1177/2515816318802771.

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Nummular headache (NH) is an unusual disorder attributed to a dysfunction of the epicranial nerves. We report a new series of cases, highlighting some clinical features, the association with other headaches, and the therapeutic response. Data of patients with NH, fulfilling ICHD-3 criteria, observed in a Headache Outpatient clinic during 5 years, were retrieved from records. Response to onabotulinumtoxinA was recorded prospectively and evaluated with a Headache Impact Test (HIT). Twenty-four patients, aged 53.8 (±14.6) years at diagnosis, 13 women, had definitive ( N = 21) or probable ( N = 3)
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Silva Rosas, Carlos, Heather Angus-Leppan, Melchor Bruno Lemp, Juan Pablo Rozas, and Alonso Humberto Quijada. "Langerhans cell histiocytosis (eosinophilic granuloma) of the skull mimicking nummular headache. Report of two cases." Cephalalgia 38, no. 4 (2017): 794–97. http://dx.doi.org/10.1177/0333102417708772.

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Background Nummular headache is a rare, recently described topographic headache defined by the circumscribed coin-shaped area of pain. It is classified as a primary headache. There is debate about whether it is due to a peripheral or central disturbance, and its relationship to migraine. Case reports We report two patients with presumed nummular headache secondary to Langerhans cell histiocytosis, both with resolution of their headaches after surgical resection. Conclusion Imaging in patients with clinical features of nummular headache is recommended, as this and other cases highlight that it
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Trucco, M., F. Mainardi, G. Perego, and G. Zanchin. "Nummular Headache." Cephalalgia 26, no. 3 (2006): 354–56. http://dx.doi.org/10.1111/j.1468-2982.2006.01065.x.

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Evans, Randolph W., and Juan A. Pareja. "Nummular Headache." Headache: The Journal of Head and Face Pain 45, no. 2 (2005): 164–65. http://dx.doi.org/10.1111/j.1526-4610.2005.05033.x.

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Grosberg, Brian M., Seymour Solomon, and Richard B. Lipton. "Nummular headache." Current Pain and Headache Reports 11, no. 4 (2007): 310–12. http://dx.doi.org/10.1007/s11916-007-0209-1.

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Wijeratne, Tissa, and Dilani Wijeratne. "Nummular headache." Sri Lanka Journal of Neurology 2, no. 1 (2013): 23. http://dx.doi.org/10.4038/sljon.v2i1.104.

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Dai, Wei, Shengyuan Yu, Jingyao Liang, and Mingjie Zhang. "Nummular headache: Peripheral or central? One case with reappearance of nummular headache after focal scalp was removed, and literature review." Cephalalgia 33, no. 6 (2013): 390–97. http://dx.doi.org/10.1177/0333102412474504.

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Background Nummular headache, or coin-shaped cephalagia, is defined as a mild to moderate, pressure-like pain that is felt exclusively in a circumscribed area. More than 200 cases of nummular headache have been reported since it was defined in 2002, but the pathogenesis remains unclear. Methods A patient with nummular headache who had the symptomatic area of his scalp removed but suffered headache reappearance was reported. All published cases of nummular headache in the English literature were reviewed and analyzed for demographic and clinical features, image and laboratory findings, and resp
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Pareja, Juan A., Teresa Montojo, and Mónica Álvarez. "Nummular Headache Update." Current Neurology and Neuroscience Reports 12, no. 2 (2011): 118–24. http://dx.doi.org/10.1007/s11910-011-0247-2.

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Robbins, MS, and BM Grosberg. "Menstrual-related nummular headache." Cephalalgia 30, no. 4 (2009): 507–8. http://dx.doi.org/10.1111/j.1468-2982.2009.01947.x.

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Cohen, Gary L. "Nummular Headache: What Denomination?" Headache: The Journal of Head and Face Pain 45, no. 10 (2005): 1417–18. http://dx.doi.org/10.1111/j.1526-4610.2005.00278_1.x.

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Dabscheck, Gabriel, and Peter Ian Andrews. "Nummular headache associated with focal hair heterochromia in a child." Cephalalgia 30, no. 11 (2010): 1403–5. http://dx.doi.org/10.1177/0333102410368439.

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Nummular headache (NH) is a recently described headache syndrome where continuous or intermittent pain is localised to a coin-shaped region of the skull. NH can be a primary headache disorder or secondary to intracranial or extracranial pathology. We report a four-year-old boy who presented with nummular headache co-localised with a patch of discoloured hair and propose a common aetiology.
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Pekova, Kalina, Vasil Todorov, Ivan Milanov та Desislava Bogdanova. "Nummular headache – а case report". Bulgarian Neurology 25, № 1 (2024): 25–27. https://doi.org/10.5281/zenodo.15379608.

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Numural headache (NG) is a rare disease that can be completely benign or a manifestation of an underlying problem. One of the main causes of NG is head trauma, superficial artery aneurysm, structural or dermatological lesion. NG is characterized by prolonged or intermittent pain in the head (most often the parietal area) with sharp boundaries, fixed size (average from 1 cm to 6 cm) with round or oval shape. Headache may occur with allodynia, hypo/hyperesthesia, paresthesia, hyperalgesia and hypersensitivity. Imaging of the head is a mandatory part of the diagnostic process. The clinical case f
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García-Azorín, David, Javier Trigo-López, Álvaro Sierra, et al. "Observational, open-label, non-randomized study on the efficacy of onabotulinumtoxinA in the treatment of nummular headache: The pre-numabot study." Cephalalgia 39, no. 14 (2019): 1818–26. http://dx.doi.org/10.1177/0333102419863023.

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Background Nummular headache is a primary headache characterised by superficial, coin-shaped pain. Superficial sensory fibre dysfunction might be involved in its pathophysiology. Considering the mechanism of action of onabotulinumtoxinA, it could be a reasonable option in treatment of nummular headache. The aim of the study was to evaluate the efficacy and tolerability of onabotulinumtoxinA in a series of nummular headache patients. Patients and methods This was an observational, prospective, non-randomized and open-label study. Nummular headache patients with at least 10 headache days in thre
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Dach, F., J. Speciali, A. Eckeli, GG Rodrigues, and CA Bordini. "Nummular Headache: Three New Cases." Cephalalgia 26, no. 10 (2006): 1234–37. http://dx.doi.org/10.1111/j.1468-2982.2006.01197.x.

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Nummular headache is proposed as a distinct type of headache in the Appendix of the second edition of the International Classification of Headache Disorders (ICHD-II). It is a chronic condition, with the following characteristics: pain is felt on a small circumscribed cranial area; pain is of mild to moderate intensity; there is no evidence of a structural abnormality. Herein, three cases fulfilling the ICHDII proposed criteria (code A13.7.1) for nummular headache are reported.
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Delva, I. I. "Nummular Headache (Clinical Observation, Discussion)." Ukraïnsʹkij žurnal medicini, bìologìï ta sportu 7, no. 6 (2022): 76–80. http://dx.doi.org/10.26693/jmbs07.06.076.

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The purpose of the study was to show the importance of using international diagnostic criteria of headache in neurological practice through description of clinical case of nummular headache. Materials and methods. Complaints, medical history, life history, results of objective and neurological examination, data of laboratory and instrumental research methods in a patient with nummular headache. Results and discussion. Patient G., 53 years old, complained of constant, dull, local, moderate pain in the right parietal area. The headache appeared gradually 5–6 months ago, without any evident trigg
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Valença, Marcelo Moraes, Claudia Cristina de Lira Santana, Laura Luiza Barbosa Menezes da Mota, Luana Gomes Ribeiro, Florisvaldo José Morais Vasconcelos Junior, and Juliana Ramos de Andrade. "Intermittent tactile nummular allodynia: expanding the spectrum of nummular headache?" Headache Medicine 16, no. 2 (2025): 120–22. https://doi.org/10.48208/headachemed.2025.18.

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IntroductionNummular headache (NH) is a rare primary headache characterized by pain in a well-defined, small, round, or oval area of the scalp, often associated with abnormal local sensations such as paresthesia or allodynia. However, sensory scalp disturbances without pain, such as intermittent tactile nummular allodynia (ITNA), remain poorly understood. This report aims to describe a case of ITNA and discuss its clinical significance in the spectrum of nummular syndromes.Case ReportA 53-year-old woman presented with a 9-year history of intermittent tactile allodynia in the right parietal reg
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Kararizou, Evangelia, Anastasia Bougea, Dimitra Giotopoulou, et al. "An Update on the Less-known Group of Other Primary Headaches – A Review." European Neurological Review 9, no. 1 (2014): 71. http://dx.doi.org/10.17925/enr.2014.09.01.71.

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Headache represents one of the most common symptoms in the emergency department. A systematic approach to headache classification is essential for diagnosis and efficient therapeutic management. New International Headache Classification (ICHD-3 beta) criteria provide a dynamic clinically useful instrument, establishing both uniform terminology and consistent operational diagnostic criteria for a broad range of headache disorders. This article reviews and highlights developments in our knowledge of “Other Primary Headaches”, including primary stabbing headache, primary cough headache, primary e
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Pareja, Juan A., and Julia Pareja. "Nummular headache: diagnosis and treatment." Expert Review of Neurotherapeutics 3, no. 3 (2003): 289–92. http://dx.doi.org/10.1586/14737175.3.3.289.

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Belskaya, G. N. Belskaya, S. B. Stepanova Stepanova, L. D. Makarova Makarova, D. A. Sergienko Sergienko, and L. G. Krylova Krylova. "Nummular headache: obeservational cohort study." Pharmateca 3_2019 (March 7, 2019): 45–50. http://dx.doi.org/10.18565/pharmateca.2019.3.45-50.

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Mohen, Sylvia A., and Matthew S. Robbins. "Harry Potter and Nummular Headache." Headache: The Journal of Head and Face Pain 52, no. 2 (2012): 323–24. http://dx.doi.org/10.1111/j.1526-4610.2011.02063.x.

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Barón, Johanna, Cristina Rodríguez, Marina Ruiz, et al. "Atypical Nummular Headache or Circumscribed Migraine: The Utility of Pressure Algometry." Pain Research and Management 20, no. 2 (2015): 60–62. http://dx.doi.org/10.1155/2015/567072.

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A peripheral mechanism has been proposed for nummular headache; however, there have been descriptions of atypical features resembling migraine. The authors describe a case in which algometry assessment facilitated the discrimination between atypical nummular headache and circumscribed migraine. A 21-year-old woman presented with a history of focal episodic pain in a circumscribed area on the left frontal region. The algometry study showed a unilateral and diffuse decrease of the pain pressure thresholds with frontal predominance, as has been proposed for migraine patients. This result led the
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Lax, Daniel N., Andrew D. Hershey, Marielle A. Kabbouche, and Joanne Kacperski. "Nummular headache in children: A case series and systematic literature review." Cephalalgia Reports 5 (January 1, 2022): 251581632210917. http://dx.doi.org/10.1177/25158163221091782.

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Background: Nummular headache is a rare primary headache disorder potentially disabling and refractory to treatment. Of over 300 reported cases, only 9 are children. Design/Methods: We searched our institutional database and PubMed for “nummular headache” and synonyms and evaluated select articles from reference lists of substantial reviews. Results: Seven children were identified from our institution and nine from 107 unique publications. Mean age at onset was 9.7 and 11.9 years in our cohort and the literature, respectively, with a female:male ratio of 2:1. Location and quality varied, and a
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Colombo, Bruno, and Massimo Filippi. "Other primary headaches. Cough headache, nummular headache and primary exercise headache: a secondary point of view." Neurological Sciences 41, S2 (2020): 377–79. http://dx.doi.org/10.1007/s10072-020-04689-8.

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Baldelli, Ilaria, Maria Lucia Mangialardi, Marzia Salgarello, and Edoardo Raposio. "Nummular Headache and Its Surgical Treatment." Plastic and Reconstructive Surgery - Global Open 8, no. 7 (2020): e2989. http://dx.doi.org/10.1097/gox.0000000000002989.

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Cupka, Bryan, and Ivan Login. "Trigeminal Neuralgia Evolving Into Nummular Headache." Neurological Bulletin 4, no. 1 (2012): 29–33. http://dx.doi.org/10.7191/neurol_bull.2012.1036.

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Pareja, Juan A. "Nummular Headache: What Denomination? A Rebuttal." Headache: The Journal of Head and Face Pain 45, no. 10 (2005): 1418. http://dx.doi.org/10.1111/j.1526-4610.2005.00278_2.x.

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Porta-Etessam, Jesús, Teresa Lapeña, Maria-L. Cuadrado, Antonio Guerrero, and Beatriz Parejo. "Multifocal Nummular Headache With Trophic Changes." Headache: The Journal of Head and Face Pain 50, no. 10 (2010): 1612–13. http://dx.doi.org/10.1111/j.1526-4610.2010.01773.x.

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Baldacci, Filippo, Angelo Nuti, Claudio Lucetti, Paolo Borelli, and Ubaldo Bonuccelli. "Nummular headache dramatically responsive to indomethacin." Cephalalgia 30, no. 9 (2010): 1151–52. http://dx.doi.org/10.1177/0333102410361539.

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Camacho-Velasquez, Jose Luis. "Nummular Headache Associated With Linear Scleroderma." Headache: The Journal of Head and Face Pain 56, no. 9 (2016): 1492–93. http://dx.doi.org/10.1111/head.12894.

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Guillem, Amparo, Francisco J. Barriga, and Santiago Giménez-Roldán. "Nummular headache associated to arachnoid cysts." Journal of Headache and Pain 10, no. 3 (2009): 215–17. http://dx.doi.org/10.1007/s10194-009-0103-9.

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Rammohan, K., Shyma M. Mundayadan, and Robert Mathew. "Nummular headache: Clinico-epidemiological features in South Indian population." Journal of Neurosciences in Rural Practice 7, no. 04 (2016): 532–36. http://dx.doi.org/10.4103/0976-3147.186984.

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ABSTRACT Context: Nummular headache (NH) is a primary disorder characterized by head pain exclusively felt in a small-rounded area typically 2–6 cm in diameter. Aims: The aim of this review is to study the clinical and epidemiological features of NH in a patient population of South India and to compare this with that of described in the international literature. Settings and Design: A prospective, observational study conducted in a tertiary care center. Materials and Methods: Patients attending the medicine and neurology outpatient departments of a tertiary referral hospital in South India dia
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Moon, Justin, Kamran Ahmed, and Ivan Garza. "Case series of sixteen patients with nummular headache." Cephalalgia 30, no. 12 (2010): 1527–30. http://dx.doi.org/10.1177/0333102410368445.

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Introduction: Nummular headache is a rare primary headache disorder described by a focal circumscribed area of pain (2–6 cm in diameter). Literature on this disorder is sparse. Patients and methods: Here, we describe a case series of 16 patients (6 men, 10 women) seen at the Mayo Clinic. Results: Mean age of onset was 50 years (range, 19–79 years) and mean duration of headache was 7.9 years (range, 0.33–40 years). Location of headache varied and was found to be an average of 3.9 cm in diameter (range, 2–10 cm). Headache was episodic (<15 days/month) in four patients and chronic (>15 days
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Filipović-Danić, Snežana, Vekoslav Mitrović, Nenad Milošević, and Aleksandar Stevanović. "Differential diagnosis distinction of nummular headache and Lichen planopilaris." Praxis medica 51, no. 1-2 (2022): 63–65. http://dx.doi.org/10.5937/pramed2202063f.

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Introduction: Nummular headache is a type of primary headache of chronic character, with a large number of described varieties in the clinical picture, and therefore the differential diagnostic consideration must include a large number of disorders related to changes in epicranial structures. Certain dermatological disorders can also include pain in a limited area of the scalp with itching, burning or burning sensation, such as Lichen Planopilaris. Case report: This is a report of a patient who was initially diagnosed with Lichen planopilaris, but after determining the parameters of the distin
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Chirchiglia, Domenico, Pasquale Chirchiglia, and Domenico La Torre. "Nummular headache – three years later: What happened." Romanian Journal of Neurology 19, no. 1 (2020): 36–37. http://dx.doi.org/10.37897/rjn.2020.1.4.

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Tayeb, Z., F. Hafeez, and Q. Shafiq. "Successful Treatment of Nummular Headache With Tens." Cephalalgia 28, no. 8 (2008): 897–98. http://dx.doi.org/10.1111/j.1468-2982.2007.01456.x.

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Cuadrado, ML, B. Valle, C. Fernández, FJ Barriga, and JA Pareja. "Bifocal Nummular Headache: The First Three Cases." Cephalalgia 29, no. 5 (2009): 583–86. http://dx.doi.org/10.1111/j.1468-2982.2008.01815.x.

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Nummular headache (NH) has been defined as a focal head pain that is exclusively felt in a small area of the head surface. Here we describe three patients who presented with focal head pain in two separate areas. This finding seems to be consistent with bifocal NH and further enlarges the clinical diversity of this headache disorder. The pathogenic mechanisms of NH may be active in multiple cranial areas in some particular patients.
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Cuadrado, María Luz, Pedro López-Ruiz, and Ángel L. Guerrero. "Nummular headache: an update and future prospects." Expert Review of Neurotherapeutics 18, no. 1 (2017): 9–19. http://dx.doi.org/10.1080/14737175.2018.1401925.

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Trucco, Marco. "Nummular headache: another case treated with gabapentin." Journal of Headache and Pain 8, no. 2 (2007): 137–38. http://dx.doi.org/10.1007/s10194-007-0375-x.

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Fernández-de-las-Peñas, C., ML Cuadrado, FJ Barriga, and JA Pareja. "Pericranial Tenderness is Not Related to Nummular Headache." Cephalalgia 27, no. 2 (2007): 182–86. http://dx.doi.org/10.1111/j.1468-2982.2007.01253.x.

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The aim of the present study was to investigate whether nummular headache (NH) patients show increased pericranial tenderness in relation to healthy subjects, and to compare pericranial tenderness between both NH and chronic tension-type headache (CTTH) patients. Three tenderness (total, cephalic and neck) scores were objectively and blinded assessed in 10 NH patients, 10 CTTH subjects and 10 healthy matched controls. No significant differences were found in any tenderness score between the symptomatic and non-symptomatic sides in NH, or between right and left sides in either CTTH or control g
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Guillem, A., FJ Barriga, and S. Giménez-Roldán. "Nummular Headache Secondary to An Intracranial Mass Lesion." Cephalalgia 27, no. 8 (2007): 943–44. http://dx.doi.org/10.1111/j.1468-2982.2007.01328.x.

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Nummular headache is a coin-shaped, chronic cephalalgia usually considered to stem from epicranial tissues. We describe a patient complaining of circumscribed pain in the head as the only symptom of a subtentorial meningioma. This observation underlines the need to revise the concept of circumscribed, referred pains in the head arising from pain-sensitive intracranial structures.
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Yamazaki, Yuu, and Keitaro Kobatake. "Successful treatment of nummular headache with Neurotropin®." Journal of Headache and Pain 12, no. 6 (2011): 661–62. http://dx.doi.org/10.1007/s10194-011-0382-9.

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Yin, Hsin-Ling, Chi Chui, Wai-Fai Tung, and Wei-Hsi Chen. "Nummular headache after trans-sphenoidal surgery: a referred pain-based headache syndrome." Neurologia i Neurochirurgia Polska 47, no. 4 (2013): 398–401. http://dx.doi.org/10.5114/ninp.2013.36764.

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Álvaro, LC, JM Garcí, and E. Areitio. "Nummular Headache: A Series with Symptomatic and Primary Cases." Cephalalgia 29, no. 3 (2009): 379–83. http://dx.doi.org/10.1111/j.1468-2982.2008.01722.x.

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Nummular headache (NH) is a primary headache adopting the form of local pain in a circumscribed area of < 7 cm in diameter in the tuber parietale, albeit it may also be located in other areas of the head. Although it is chronic, it is commonly associated with exacerbations and short periods of remission. Here we report four cases. Two of them could not be considered primary: in one the pain was related to an underlying, pointed and benign lesion disclosed only by magnetic resonance imaging (case 1); the second one had persistent NH days after trans-sphenoidal surgery for a pituitary adenoma
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Sampaio Rocha-Filho, Pedro Augusto, Moises Dominguez, Christopher L. Robinson, and Sait Ashina. "Uses of Botulinum Toxin in Headache and Facial Pain Disorders: An Update." Toxins 17, no. 7 (2025): 314. https://doi.org/10.3390/toxins17070314.

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Botulinum toxin is a neurotoxin that is used in the treatments for several medical conditions, such as dystonia, spasticity, hemifacial spasm, overactive bladder, and hyperhidrosis. This toxin can potentially treat several pain disorders through botulinum toxin’s ability to inhibit the release of pro-nociceptive neurotransmitters into the synaptic cleft and its possible action on the central nervous system. This narrative review addresses the use of botulinum toxin in treating primary and secondary headaches and facial pain disorders. The highest level of evidence supporting its use varies amo
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Pareja, Juan A., Julia Pareja, and Julio Yangüela. "Nummular headache, trochleitis, supraorbital neuralgia, and other epicranial headaches and neuralgias: the epicranias." Journal of Headache and Pain 4, no. 3 (2003): 125–31. http://dx.doi.org/10.1007/s10194-003-0046-5.

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Pareja, Juan A., Julia Pareja, Francisco J. Barriga, et al. "Nummular Headache: A Prospective Series of 14 New Cases." Headache: The Journal of Head and Face Pain 44, no. 6 (2004): 611–14. http://dx.doi.org/10.1111/j.1526-4610.2004.446011.x.

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Campbell, William W., and Roberto J. Sartori. "Nummular Erythema in a Patient With Chronic Daily Headache." Headache: The Journal of Head and Face Pain 43, no. 10 (2003): 1112. http://dx.doi.org/10.1046/j.1526-4610.2003.03215.x.

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Panagariya, A. "Bifocal Nummular Headache: A Series of 6 New Cases." Yearbook of Neurology and Neurosurgery 2012 (January 2012): 16–17. http://dx.doi.org/10.1016/j.yneu.2011.12.004.

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Fernandez-de-las-Penas, Cesar, Maria Luz Cuadrado, Francisco J. Barriga, and Juan A. Pareja. "Local Decrease of Pressure Pain Threshold in Nummular Headache." Headache: The Journal of Head and Face Pain 46, no. 7 (2006): 1195–98. http://dx.doi.org/10.1111/j.1526-4610.2006.00511.x.

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