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Thèses sur le sujet « Onset of diseases »

Auteur : Grafiati

Publié le 7 juin 2025

Mis à jour le 2 août 2025

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1

Hennig, Branwen Johanna Wanda. "Genetic polymorphisms and early-onset periodontal diseases." Thesis, University of Newcastle Upon Tyne, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311107.

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Mallbris, Lotus. "Psoriasis : studies of phenotype at onset and of associated cardiovascular morbidity /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-414-7/.

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Upstill-Goddard, Rosanna. "Genetic dissection of early-onset breast cancer and other genetic diseases." Thesis, University of Southampton, 2015. https://eprints.soton.ac.uk/386938/.

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Genetic variation in the genome of an individual plays a key role in susceptibility to many human diseases. Analysis of the genetic variants harboured by individuals presenting with disease phenotypes is crucial for unravelling the genetic landscape of human disease. The methods that are now available for the characterisation of genetic variants, including single nucleotide polymorphism (SNP) microarrays and next generation sequencing, make it possible to explore all genetic variants harboured within an individual with a specific disease phenotype, allowing for tailoring of treatments. This th

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Gaffney, Jessica. "The Benefits of Nutritional Treatments for Very Early Onset Inflammatory Bowel Disease (VEO-IBD) Patients." Scholarship @ Claremont, 2018. http://scholarship.claremont.edu/cmc_theses/1808.

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Inflammatory bowel disease (IBD) is a group of diseases in the gastrointestinal field that is becoming more commonly diagnosed among patients. IBD is usually characterized as a group of chronic diseases affecting the digestive tract that are caused by a multitude of factors including genetic, environmental, mucosal, and immune contributors. One of the subgroups of IBD is very early onset IBD (VEO-IBD), which is diagnosed in children under the age of 6. VEO-IBD is a rare yet unique case of IBD, which reports poor response to conventional adult-onset IBD treatments. Nutrition is an alternative t

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Giunta, Michele. "Exosomal protein deficiencies : how abnormal RNA metabolism results in childhood-onset neurological diseases." Thesis, University of Newcastle upon Tyne, 2017. http://hdl.handle.net/10443/3669.

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RNA metabolism is of critical importance for normal cellular functions and needs to be finely tuned in order to maintain stable conditions within the cell. The exosome complex is the most important RNA processing machinery, responsible for the correct processing of many different types of RNAs and interacting with different co-factors which bind and carry specific subtypes of RNA for degradation to the complex. Mutations in exosome complex subunits (EXOSC3, EXOSC8) were reported to cause severe childhood onset complex neurological disorders presenting with pontocerebellar hypoplasia type 1 (PC

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Rudan, Igor. "Effects of inbreeding on human quantitative traits and complex common diseases of late-onset." Thesis, University of Edinburgh, 2006. http://hdl.handle.net/1842/29345.

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In a historic sample of 2,761 examinees from isolate village populations of the islands of Brac, Hvar and Korcula, Croatia, collected through field work undertaken in 1970’s and 1980’s, individual inbreeding coefficients were computed based on genealogical records. Inbreeding showed strong positive effect on blood pressure and negative on cortical index. The 14 villages were revisited in 2000 to assess the prevalence of learning disability and of common complex diseases of late onset. A cohort study and an ecological study, after appropriate standardization, both showed that inbreeding increas

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Gaddam, Sathvika, Momani Laith Al, Ali Bokhari, and Melania Bochis. "CRITICAL UPPER LIMB ISCHEMIA IN A PATIENT WITH NEW-ONSET ATRIAL FIBRILLATION." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/asrf/2018/schedule/70.

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Atrial fibrillation is the most common type of serious dysrhythmia, with increasing prevalence in older age groups. Thromboembolism is a serious complication seen with atrial fibrillation and can range from ischemic stroke, mesenteric ischemia to acute limb ischemia. The annual incidence of acute limb ischemia secondary to atrial fibrillation is 0.14%[1]. Here we report a case of critical limb ischemia with brachial artery occlusion due to an embolus in a patient with new onset atrial fibrillation. A 90 year-old female patient presented to the hospital with complaints of shortness of breath on

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Liang, Chengya. "High Saturated Fat Diet Induces Gestational Diabetes, Perinatal Skeletal Malformation and Adult-Onset Chronic Diseases." Diss., Virginia Tech, 2009. http://hdl.handle.net/10919/26700.

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Adult exposure to high fat diet (HFD) has been linked to increased risk of musculoskeletal, cardiovascular, and metabolic diseases; however, the contribution of gestational HFD to elevated oxidative stress (OS), perinatal cardiovascular, skeletal, and metabolic dysfunction as well as long-term effects on adult offspring are incompletely understood. Pathophysiologic mechanisms linking gestational HFD, OS, and insulin resistance to perinatal development and adult-onset chronic diseases are explored in the present study, and maternal antioxidant (quercetin) is offered as a potential preventive d

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Griffith, Abigail Susanne. "Changes in Activity and Milk Components Around the Onset of Peripartum Diseases in Dairy Cows." Thesis, Virginia Tech, 2014. http://hdl.handle.net/10919/50414.

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Activity and milk components were examined around disease onset in the periparturient period. Cows were monitored for daily rest bouts, rest duration, rest time, and step activity from -21 to +30 d relative to calving. Lactose concentration, fat to protein ratio (F:P), and milk yield were monitored. Diseases analyzed were assisted calving, mastitis, subclinical ketosis (SK), and a multiple disease category (MULTI) for animals who experienced more than one disease. Rest bouts decreased (d 0), step activity increased (d 0), and rest duration decreased (d -1) in animals that experienced assisted

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Lynch, Marcus Phillip. "Evaluation of peptide based vaccines and inhibitors to prevent the onset of HTLV-1 associated diseases." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1164739126.

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OTTOLENGHI, SARA. "ONSET OF ANEMIA IN PULMONARY DISEASES: ROLE OF HYPOXIA, OXIDATIVE STRESS, IRON METABOLISM AND HEMATOPOIETIC REGULATORS." Doctoral thesis, Università degli Studi di Milano, 2021. http://hdl.handle.net/2434/839664.

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BACKGROUND: In patients affected by severe hypoxia, such as those with Acute Respiratory Distress Syndrome (ARDS), an acute condition characterized by sudden onset of severe hypoxemia and a severe manifestation of COVID19, anemia is a common complication. It remains to be established weather iron metabolism, especially hepcidin, and oxidative stress are involved in negatively interfering with physiological hematopoietic compensatory mechanisms to hypoxia. AIMS: - To investigate etiology and progression of anemia in ARDS patients, through biomarkers of inflammation, iron metabolism and oxidat

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Wooldridge, Marion Joan Anstee. "A study of the incubation period, or age at onset, of the transmissible spongiform encephalopathies/prion diseases." Thesis, London School of Hygiene and Tropical Medicine (University of London), 1995. http://researchonline.lshtm.ac.uk/682220/.

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In order to model epidemics of infectious diseases, particularly to estimate probable numbers of cases with onset at any particular time, it is necessaiy to incorporate a term for the incubation period frequency distribution. Sartwell's hypothesis states that the incubation period frequency distribution for infectious disease is generally a log-normal distribution, based on his examination of disease with short incubation periods. However, it may not apply to diseases with long incubation periods. During the course of an epidemic of a disease with a long incubation period, left and right censo

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Jagoda, Allison M. "Prevalence of abnormal heart rate acceleration at the onset of exercise in an asymptomatmic, self-referred adult population." CardinalScholar 1.0, 2010. http://liblink.bsu.edu/uhtbin/catkey/1567413.

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Purpose: Little is known about the heart rate (HR) responses at the onset of exercise, at peak exercise, and recovery in apparently healthy men and women. The purpose of this study was to determine the prevalence of abnormal HR acceleration at the onset of exercise, define the HR acceleration profile, determine if traditional cardiovascular disease (CVD) risk factors are associated with abnormal HR acceleration, and identify whether abnormal chronotropic responses cluster with abnormal HR acceleration in an asymptomatic, self-referred, adult population. Methods: A retrospective examination of

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Assrawi, Eman. "Molecular and cellular bases of systemic autoinflammatory disorders including Adult-onset Still’s disease." Electronic Thesis or Diss., Sorbonne université, 2019. http://www.theses.fr/2019SORUS007.

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Les maladies auto-inflammatoires systémiques (SAIDs) sont des maladies rares caractérisées par des attaques fébriles récurrentes et une inflammation systémique stérile. Leur étiologie est expliquée par des mutations dans des gènes induisant une dérégulation du système immunitaire. Les travaux présentés dans cette thèse visaient à (i) étudier les conséquences fonctionnelles d’un variant NLRP3 identifié dans deux familles distinctes, (ii) identifier les bases moléculaires de l’urticaire inflammatoire chronique et (iii) étudier les bases moléculaires et cellulaires de la maladie de Still de l’adu

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Shah, A. D. "Using electronic health records to investigate blood biomarkers and onset of cardiovascular diseases : example of differential white cell count." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1472441/.

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BACKGROUND: Electronic health records are invaluable for studying clinically recorded biomarkers and outcomes, but conversion of raw datasets to a research-ready format and replication of analyses can be challenging. The differential white cell count is a common blood test which may reflect inflammation and cardiovascular risk, but previous epidemiological studies have been small or in selected populations. AIM: To develop methods to assist in using electronic health record databases for research, and apply them to an exemplar study investigating differential white cell counts and onset of car

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Otto, Delita. "Exploring underlying mechanisms driving the onset of stress-induced insulin resistance." Thesis, Stellenbosch : Stellenbosch University, 2012. http://hdl.handle.net/10019.1/20125.

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Thesis (MSc)--Stellenbosch University, 2012.<br>ENGLISH ABSTRACT: Physical and psychological stressors trigger activation of the hypothalamo-pituitary-adrenocortical (HPA) axis that leads to enhanced secretion of glucocorticoids e.g. cortisol. Moreover, chronic activation of this pathway may elevate oxidative stress that is linked to the onset of insulin resistance and cardiovascular diseases (CVD). Our laboratory previously found that oxidative stress increases flux through metabolic circuits such as the hexosamine biosynthetic pathway (HBP), in effect increasing its modification of tar

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Comas, Rovira Montserrat. "Cardiac dysfunction by tissue doppler in earty-and late-onset fetal growth restriction." Doctoral thesis, Universitat de Barcelona, 2011. http://hdl.handle.net/10803/51517.

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SUMMARY 1) Background Fetal growth restriction (FGR) is present in 5-10% of the pregnancies and is associated to high perinatal and long-term cardiovascular morbidity. Subclinical cardiac dysfunction has previously been described in severe and early FGR cases, but not in milder forms of late-FGR. The main aim of this thesis was to assess cardiac function by new echocardiographic techniques on myocardial imaging as Tissue Doppler Imaging (TDI), in early- and late-onset FGR cases. 2) Methods First, tissue Doppler was applied in a cohort of normally growth fetuses by TDI in order to d

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Finnsson, Johannes. "Radiological studies of LMNB1-related autosomal dominant leukodystrophy and Marinesco-Sjögren syndrome." Doctoral thesis, Uppsala universitet, Radiologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-303171.

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There are approximately 6000 to 8000 rare diseases, each with a prevalence of less than 1 / 10 000, but in aggregate affecting 6 to 8% of the population. It is important to evaluate disease development and progression to know the natural course of any disease. This information can be utilized in diagnostics and in assessing effects of therapeutic interventions as they become available. This thesis describes the natural clinical history and evolution of imaging findings of two rare diseases over approximately two decades. Papers I, II and III present clinical, magnetic resonance imaging (MRI),

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Jones, Lloyd Gregory, and Cynthia Ann Plampin. "Correlation of stress and predisposition in onset of illness in Masters of Social Work students." CSUSB ScholarWorks, 2002. https://scholarworks.lib.csusb.edu/etd-project/2093.

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This study addressed the specific problem of whether there is a significant correlation between stress and the onset of predisposed disease. Because most graduate programs are stressful and it is known that several social work graduate students in one cohort at CSUSB were diagnosed with diabetes as well as migraines and depression, the population for this study was Master's of Social Work (MSW) students at California State University, San Bernardino, (CSUSB).

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Robertson, Chadia L. "Analysis of the Role of Astrocyte Elevated Gene-1 in Normal Liver Physiology and in the Onset and Progression of Hepatocellular Carcinoma." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3573.

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First identified over a decade ago, Astrocyte Elevated Gene-1 (AEG-1) has been studied extensively due to early reports of its overexpression in various cancer cell lines. Research groups all over the globe including our own have since identified AEG-1 overexpression in cancers of diverse lineages including cancers of the liver, colon, skin, prostate, breast, lung, esophagus, neurons and neuronal glia as compared to matched normal tissue. A comprehensive and convincing body of data currently points to AEG-1 as an essential component, critical to the progression and perhaps onset of cancer. AEG

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Scarpa, Carlotta. "The immunological response to breast implant: the role of cells and cytokines in the periprosthetic capsule and their involvement in the onset of the autoimmune diseases." Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3426173.

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Since their discovery breast prostheses have been criticized for being responsible for triggering systemic autoimmune disease. The presence of breast implants causes a natural foreign body reaction characterized by the infiltration of macrophages and T-cells. In order to understand which immunological pathways could be responsible for giving rise to, and the development of, connective tissue disease such as systemic sclerosis, I considered the cells and cytokines involved, focusing on the relationship between tissue growth factor-β, interleukin (IL)-1, IL-6 and T helper 17 and/or T regulatory

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White, Clive David. "Late-onset Blount's disease." Master's thesis, University of Cape Town, 2011. http://hdl.handle.net/11427/11634.

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Includes bibliographical references.<br>In 1937 WP Blount published a review of tibia vara or osteochondrosis deformans of the proximal tibia. Late-onset Blount's disease is varus deformity of the proximal tibia that occurs at or after 6 years old (excluding late presenting infantile Blount's) and has an associated femoral varus.

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Melki, Isabelle. "Clinical and molecular characterisation of type I interferonopathies." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCB122/document.

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Les interférons de type I (IFN I) sont des cytokines antivirales aux propriétés puissantes. L’induction, la transmission et la résolution de la réponse immunitaire engendrée par les IFN I est minutieusement régulée. Le concept d’interféronopathie de type I, récemment individualisé par notre équipe, repose sur l’hypothèse que certaines pathologies seraient secondaires au déséquilibre de ces voies de signalisation complexes et à la sécrétion excessive et inappropriée d’IFN I. L’inhibition de celle-ci par des thérapeutiques ciblées permettrait de valider cette hypothèse, si les symptômes allégués

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Budkowski, Emily T. "VOICE ONSET TIME IN PARKINSON DISEASE." Bowling Green State University / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1174747354.

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Bassich-Zeren, Celia J. "Vocal dysfunction in young-onset Parkinson's disease." College Park, Md. : University of Maryland, 2004. http://hdl.handle.net/1903/1823.

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Thesis (Ph. D.) -- University of Maryland, College Park, 2004.<br>Thesis research directed by: Hearing and Speech Sciences. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.

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Godbolt, Alison Kate. "Studies of young onset familial Alzheimer's disease." Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612760.

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Lahiri, N. "Identification of markers of disease onset and progression in Huntington's Disease." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1415654/.

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Huntington’s Disease is a progressive, adult onset, neurodegenerative disease. It is inherited in an autosomal dominant fashion and is caused by a trinucleotide repeat expansion in huntingtin, which encodes the protein huntingtin. The length of the expanded trinucleotide repeats accounts for some, but not all of the age of onset of the condition. Despite the monogenic basis of Huntington’s disease, the clinical features display marked variability within families and between those who carry the same length expansion. The variability in age of onset and in clinical features is likely to be due t

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Quinn, Niall. "Young onset of Parkinson's disease and juvenile parkinsonism." Thesis, University of Cambridge, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283845.

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Gomes, Antonio Eduardo. "Lifetime and disease onset distributions from incomplete observations /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/8972.

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Quiroz-Gaviria, Yakeel T. "Brain changes in presymptomatic early-onset Alzheimer's disease." Thesis, Boston University, 2013. https://hdl.handle.net/2144/13611.

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Thesis (Ph.D.)--Boston University PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>What are the earliest brain changes associated with genetic predisposition to Alzheimer's disease (AD)? This thesis used structural and functional magnetic resonance imaging (MRI) and event-related potentials (

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Ravi-Shankar, Prasad. "Factors which predispose to the onset of autoimmune disease." Connect to this title online, 2005. http://hdl.handle.net/1811/350.

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Thesis (Honors)--Ohio State University, 2005.<br>Title from first page of PDF file. Document formattted into pages: contains, 12 p.; also includes graphics. Includes bibliographical references. Available online via Ohio State University's Knowledge Bank.

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Wickremaratchi, Mirdhu. "Epidemiological study of young and later onset Parkinson's disease." Thesis, Cardiff University, 2009. http://orca.cf.ac.uk/54968/.

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Parkinson's disease (PD) is a common neurodegenerative condition and the risk of developing it is age dependent, the prevalence increasing with advancing age. There are relatively little published data on frequency and clinical features of Young Onset Parkinson's disease (YOPD) and it is uncertain whether this subgroup of PD is a different disease entity to later onset Lewy body PD. Investigation of this question is the main focus of this research thesis. This work has two components—the first provides an estimate of the prevalence of PD in Cardiff and describes age at onset, the second

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Hamilton, Gillian. "Unravelling the genetic components of late onset Alzheimer's disease." Thesis, King's College London (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.420318.

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Bourdon, Victoria Louise. "Searching for susceptibility genes for late-onset Alzheimer's disease." Thesis, King's College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.439298.

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Naler, Lynette Brigitte. "Epigenomic and Transcriptomic Changes in the Onset of Disease." Diss., Virginia Tech, 2021. http://hdl.handle.net/10919/103388.

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Current sequencing technologies allows researchers unprecedented insight into our biology, and how these biological mechanisms can become distorted and lead to disease. These aberrant mechanisms can be brought about by many causes, but some occur as a result of genetic mutations or external factors through the epigenome. Here, we used our microfluidic technology to profile the epigenome and transcriptome to study such aberrant mechanisms in three different diseases and illnesses: breast cancer, chronic inflammation, and mental illness. We profiled the epigenome of breast tissue from healthy wo

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Braganza, Giselle. "Neuropsychological deficits in early versus late onset Alzheimer's Disease /." View abstract, 2000. http://library.ccsu.edu/ccsu%5Ftheses/showit.php3?id=1612.

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Thesis (M.A.)--Central Connecticut State University, 2000.<br>Thesis advisor: Charles Mate-Kole. " ... in partial fulfillment of the requirements for the degree of Master of Arts in [in Psychology]." Includes bibliographical references (leaves 46-60).

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Mottawea, Walid Abd El-Fattah El-Sayed. "Microbiota-Host Symbiosis In First-Onset Pediatric Inflammatory Bowel Disease." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32125.

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In recent years, the association between inflammatory bowel diseases (IBDs) and gut microbiota has been extensively studied in adults using post-treatment cohorts of patients. However, microbial composition and functional interplay between host genetics and microorganisms in newly diagnosed early IBD onset remain poorly defined. Using colonoscopic mucosal washes to collect mucosal-luminal microbiota from different intestinal locations, we studied the gut microbiome in a large number of children with either Crohn’s disease (CD) or ulcerative colitis (UC). Although no significant difference in t

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Shrestha, Nirajan. "Role of High Maternal Linoleic Acid on Offspring Health." Thesis, Griffith University, 2021. http://hdl.handle.net/10072/403638.

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Maternal nutrition during pregnancy plays a critical role in the adult-onset of disease in a mother’s children. The first 1000 days, spanning from conception to two years of life, are an important period when appropriate nutritional needs must be ensured for long-term health. Studies have shown that inadequate nutritional condition in utero and early life increases the risk of developing chronic conditions later in life. In recent years, the intake of linoleic acid (LA) has increased gradually in human populations, due to changes in a dietary pattern that have resulted in increased consumption

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Malek, Naveed. "Variation in Parkinson's disease : age, gender, genotype and phenotype correlations in early onset disease." Thesis, University of Glasgow, 2014. http://theses.gla.ac.uk/5602/.

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There is a wide variation in the phenotypic expression, progression rates, therapy response and complications in Parkinson’s disease (PD). The primary research objective in this thesis was to analyse the variation in the 4 domains of phenotypic expression i.e. motor, non-motor, cognitive, and quality of life in a subset of early onset Parkinson’s disease (EOPD) patients from the PRoBaND study, in the United Kingdom. The secondary objective was to explore the factors responsible for this variation or heterogeneity in the clinical characteristics. Linking genotypes with phenotypes, besides evalu

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Mathers, H. M. C. "Assessment of MHC haplotype in early-onset inflammatory bowel disease." Thesis, Queen's University Belfast, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.419507.

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Chen, Lu-hua, and 陈璐华. "Genetic risk factors for late-onset Alzheimer's disease in Chinese." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B49617588.

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Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, with genetic factors playing critical roles in its pathogenesis. Mutations in APP, PSEN1 and PSEN2 genes are confirmed to be causative risk factors for early-onset Alzheimer’s disease (EOAD). For late-onset Alzheimer’s disease (LOAD), growing evidence suggests it is caused by multiple genetic risk factors in corporation with the environmental exposures. Although, so far, APOE is the most well recognized common genetic risk factor for LOAD, other susceptible candidate genes, such as CR1, CLU and PICALM, have recently been id

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Holmes, Clive. "The clinical phenotype and genotype of late onset Alzheimer's disease." Thesis, King's College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251683.

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Allen, Mariet. "Identification of genetic influences in late-onset Alzheimer's disease (LOAD)." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5952.

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Late-onset Alzheimer’s disease (LOAD) is the most common form of dementia, with an incidence of up to 50% in western populations over the age of 85 and a high heritability (up to 80%). The identification of risk factors for the development of LOAD is imperative for improving our understanding of this disease and for identifying therapeutic targets for treatment or prevention. Currently, the major known risk factors for the development of LOAD are age and the ApoE ε4 genotype. Previous studies have implicated plasma levels of the amyloid beta (Aß) peptide as a LOAD-associated quantitative trait

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Wikström, Anna-Karin. "Biochemical and Epidemiological Studies of Early-Onset and Late-Onset Pre-Eclampsia." Doctoral thesis, Uppsala University, Department of Women's and Children's Health, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8279.

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<p>Biochemical and epidemiological aspects of pre-eclampsia were investigated, with the main focus on possible pathophysiological differences between early-onset and late-onset disease.</p><p>In pre-eclamptic women poor correlation was found between albumin-creatinine ratio (ACR) in a random urine sample and total amount of albumin in a 24-hour urine collection. <i>(Paper I)</i><b> </b></p><p>In a cohort of women giving birth in Sweden in 1973-82 we estimated the adjusted incidence rate ratio (IRR) for ischaemic heart disease (IHD) during the years 1987–2001. The adjusted IRR for development o

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Espinosa, Castaneda Carolina. "Ascertainment bias in estimating rates of onset of early-onset Alzheimer's disease : a critical illness and life insurance application." Thesis, Heriot-Watt University, 2006. http://hdl.handle.net/10399/137.

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Krüger, J. (Johanna). "Molecular genetics of early-onset Alzheimer's disease and frontotemporal lobar degeneration." Doctoral thesis, University of Oulu, 2010. http://urn.fi/urn:isbn:9789514263156.

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Abstract Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD) are the two most common neurodegenerative diseases leading to early onset dementia (< 65 years). Mutations in the amyloid precursor protein (APP), presenilin 1 (PSEN1) and presenilin 2 (PSEN2) genes cause a proportion of familial early-onset AD (eoAD), while the microtubule-associated protein tau (MAPT) and progranulin (PGRN) mutations have been identified in FTLD patients. Only a few PSEN1 and APP mutations have previously been found in Finnish AD patients, and one MAPT mutation in a FTLD family, while the role

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Durno, Carol Anne. "Mode of inheritance and demographics of pediatric-onset inflammatory bowel disease." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape8/PQDD_0005/MQ45905.pdf.

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Harold, Denise. "Functional and positional candidate gene studies of late-onset Alzheimer's disease." Thesis, Cardiff University, 2004. http://orca.cf.ac.uk/54097/.

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Alzheimer's disease is a neurodegenerative disorder characterised by progressive memory impairment, a decline in language function and a variety of behavioural symptoms. The majority of AD cases have an age at onset above 65 years and exhibit no clear pattern of inheritance. The only known genetic risk factor this late onset AD, LOAD, is the [Special character omitted]4 allele of the apolipoprotein E gene on chromosome 19. There is significant evidence of linkage to LOAD on chromosome 10q21-23. Therefore, nine candidate genes that map to this region were examined as susceptibility loci for the

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Sims, Rebecca. "Searching for susceptibility genes for psychosis in late-onset Alzheimer's disease." Thesis, Cardiff University, 2009. http://orca.cf.ac.uk/55872/.

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A number of behavioural symptoms are commonly displayed by Alzheimer's disease (AD) sufferers. Behavioural disturbances in AD can include affective symptoms, agitation, aggression and psychosis (Burns et al. 1990a Burns et al. 1990b Burns et al. 1990c). Alois Alzheimer was the first to document psychosis in the disease bearing his name, during his description of the clinical presentation of a patient upon admission to the Frankfurt asylum in 1906 (Alzheimer 1995 Schneider and Dagerman 2004).

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Archer, Nicola. "Midlife personality and the clinical profile of late-onset Alzheimers disease." Thesis, King's College London (University of London), 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.498363.

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