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Articles de revues sur le sujet « PgD-normal »

Auteur : Grafiati

Publié le 2 juin 2025

Mis à jour le 31 juillet 2025

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1

Neeraj, Kumar Tomar, Zulfeqarr Fahed, and Sharma M.C. "Softly pgD- Normal Spaces." MATHEMATICS EDUCATION LIX, no. 1, March 2025 (2025): 1–17. https://doi.org/10.5281/zenodo.15551191.

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          <em>    The aim of this paper is to introduce a new class of softly normal called softly pgD- normality by using pgD-open sets and obtained several properties of such a space. We discuss many properties of this new space and we give some properties that connect this new spaces with some other topological spaces, also we present some examples and counter examples that show the relationships between softly pgD- normal spaces and some other topological spaces, also we introduced the concept of pgD-normal, almost pgD-normal, quasi pgD-normal, mildly pgD

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Tulay, P., M. Gultomruk, N. Findikli, and M. Bahceci. "Poor embryo development and preimplantation genetic diagnosis outcomes of translocations involving chromosome 10: Do we blame genetics?" Zygote 23, no. 5 (2014): 778–84. http://dx.doi.org/10.1017/s0967199414000422.

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SummaryBalanced reciprocal translocation carriers are usually phenotypically normal. Although the reproductive risk of these carriers varies, they generally have a lower chance to produce normal or balanced gametes. Preimplantation genetic diagnosis (PGD) is offered to these patients to increase their chances of becoming pregnant by selecting a balanced embryo for transfer. This study aimed to analyse the development and the PGD outcome of the embryos obtained from reciprocal translocation carriers focusing on ones with chromosome 10 rearrangements. In total, 27 reciprocal translocation carrie

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Deng, Yuan-xiong, Yu-shuang Chen, Wei-ran Zhang, et al. "Polysaccharide fromGynura divaricatamodulates the activities of intestinal disaccharidases in streptozotocin-induced diabetic rats." British Journal of Nutrition 106, no. 9 (2011): 1323–29. http://dx.doi.org/10.1017/s0007114511001693.

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During diabetes, structural and functional changes in the alimentary tract are known to take place resulting in an increased absorption of intestinal glucose and alterations in the activities of brush-border disaccharidases. To elucidate the effect of administrating polysaccharide fromGynura divaricata(PGD) on disaccharidase activities, the specific activities of intestinal disaccharidases, namely sucrase, maltase and lactase, were measured in streptozotocin-induced diabetic rats. Normal control and diabetic rats were treated by oral administration with PGD. Specific activities of intestinal d

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Jin, Zhaosheng, Ka Chun Suen, Zhiping Wang, and Daqing Ma. "Review 2: Primary graft dysfunction after lung transplant—pathophysiology, clinical considerations and therapeutic targets." Journal of Anesthesia 34, no. 5 (2020): 729–40. http://dx.doi.org/10.1007/s00540-020-02823-6.

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Abstract Primary graft dysfunction (PGD) is one of the most common complications in the early postoperative period and is the most common cause of death in the first postoperative month. The underlying pathophysiology is thought to be the ischaemia–reperfusion injury that occurs during the storage and reperfusion of the lung engraftment; this triggers a cascade of pathological changes, which result in pulmonary vascular dysfunction and loss of the normal alveolar architecture. There are a number of surgical and anaesthetic factors which may be related to the development of PGD. To date, althou

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Lietman, Steven A., James Goldfarb, Nina Desai, and Michael A. Levine. "Preimplantation Genetic Diagnosis for Severe Albright Hereditary Osteodystrophy." Journal of Clinical Endocrinology & Metabolism 93, no. 3 (2008): 901–4. http://dx.doi.org/10.1210/jc.2007-2040.

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Abstract Context: Preimplantation genetic diagnosis (PGD) enables the selection of embryos without mutations for implantation and has not been described to our knowledge for mutations in GNAS. Phocomelia in a patient with Albright hereditary osteodystrophy (AHO) has also not been previously described. Objective: The aim of this study was to identify a GNAS mutation in a patient with a severe form of AHO and pseudohypoparathyroidism type 1a with phocomelia and to perform PGD on embryos derived by in vitro fertilization to deliver an unaffected infant. Design: A proband and his family are descri

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Saidatuzzahroh, Nur. "#176 : The Relationship Between Blastocyst Morphology and PGD Result." Fertility & Reproduction 05, no. 04 (2023): 707–9. http://dx.doi.org/10.1142/s2661318223744193.

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Background and Aims: Blastocyst morphology has been clinically assessed during the selection of blastocyst for transfer and cryopreservation, and the morphological grading scheme has gained wide acceptance. Blastocyst grading according to Gardner et al. (20) early blastocyst, blastocoel less than half of the blastocyst (1AA), blastocyst with blastocoel more than half of the blastocyst (2AA), blastocyst with blastocoel fill the blastocyst (3AA), and Expanded Blastocyst (4AA/4BB/4CC). Morphology blastocyst with good quality determining the success of PGD. Preimplantation genetic diagnosis (PGD)

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Tulay, P., M. Gultomruk, N. Findikli, and M. Bahceci. "Number of embryos biopsied as a predictive indicator for the outcome of preimplantation genetic diagnosis by fluorescence in situ hybridisation in translocation cases." Zygote 24, no. 1 (2015): 107–14. http://dx.doi.org/10.1017/s0967199414000793.

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SummaryThis study aimed to investigate the optimum number of embryos to be biopsied in order to increase the likelihood of obtaining a balanced/normal embryo following preimplantation genetic diagnosis (PGD) by fluorescence in situ hybridisation (FISH) for translocation carriers. Patients with low number of fertilised oocytes (≤5) or low number of embryos available for PGD (<7) underwent multiple hormonal stimulation cycles and their embryos from each cycle were vitrified and accumulated to obtain at least three embryos for PGD. Fifty-seven PGD cycles were performed for translocation carrie

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Pujol, Aïda, Jordi Benet, Catherine Staessen, et al. "The importance of aneuploidy screening in reciprocal translocation carriers." Reproduction 131, no. 6 (2006): 1025–35. http://dx.doi.org/10.1530/rep.1.01063.

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The purpose of this study is to investigate the aneuploidy rate and the mosaicism of chromosomes not involved in reciprocal translocations. Aneuploidy screening (AS) (13, 16, 18, 21 and 22) was performed as a re-analysis on fixed blastomeres from 126 embryos already analysed in preimplantation genetic diagnosis (PGD) cycles of eight female and five male reciprocal translocation carriers who had not achieved a pregnancy. A successful diagnosis for AS was achieved in 91.3% of embryos; 30.9% were euploid and 60.3% were aneuploid for the five chromosomes analysed. Of the embryos, 8.7% were euploid

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Lee, Yong-Heum, Myeong Soo Lee, Byung-Cheul Shin, et al. "Effects of Acupuncture on Potential Along Meridians of Healthy Subjects and Patients with Gastric Disease." American Journal of Chinese Medicine 33, no. 06 (2005): 879–85. http://dx.doi.org/10.1142/s0192415x05003478.

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The purpose of this study was to investigate the differences in bio-potential in the stomach meridians of 20 normal healthy control subjects (NHC) and 20 patients with gastric disease (PGD). We measured changes in potential between ST-39 and ST-37 on the stomach meridian in response to invasive insertion of a needle at ST-36. The response patterns of NHC were regular in both the left and right meridians, whereas the response patterns of PGD were irregular. The potential of the NHC was significantly higher than that of the PGD group. The potential values in the left and right meridians of NHC w

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SAMONTE, SOPB, DL SANCHEZ, JBB ALPUERTO, LT WILSON, Z. YAN, and MJ THOMSON. "HETEROSIS AND HETEROTIC GROUPING EFFECTS ON GRAIN YIELD, HEIGHT, TILLER DENSITY, AND DAYS TO HEADING IN HYBRID RICE (ORYZA." SABRAO Journal of Breeding and Genetics 55, no. 3 (2023): 623–39. http://dx.doi.org/10.54910/sabrao2023.55.3.3.

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Heterotic groups are necessary for high vigor in hybrid rice. However, hybrids produced from crosses between parents from different rice subspecies (i.e., Indica × Japonica) have extensive incompatibility issues exhibited by low seed sets. The study objectives were to evaluate the heterosis in grain yield and yield-related traits between hybrids produced from low and high parental genetic distances (PGDs) and demonstrate the heterotic group approach in rice. From PGDs, eight and three hybrids were assigned to the low and high PGD hybrid groups, respectively. Neighbor-joining clustering and mod

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Kemeç, Zeki. "Prognostic importance of platelet/lymphocyte ratio and neutrophil/lymphocyte ratio in proteinuria associated with primary glomerular diseases." Medical Science and Discovery 9, no. 5 (2022): 272–77. http://dx.doi.org/10.36472/msd.v9i5.714.

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Objective: Proteinuria is associated with inflammation, endothelial dysfunction, platelet activation, and progression of kidney disease. The biological mechanisms by which platelet/lymphocyte rate (PLR) and neutrophil/lymphocyte rate (NLR) variables play a role in mediating protein excretion are not fully known. Here we aimed to compare NLR and PLR variables between patients with the primary glomerular disease (PPGD) with normal estimated glomerular filtration rate (eGFR) and healthy individuals (HIs). We divided the primary glomerular disease (PGD) participants into three sub-groups according

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Bouatia, Mohammed, Rafik Demagh, and Zohra Derriche. "Numerical Investigation on Buried Pipelines Subjected to Permanent Ground Deformations Due to Shallow Slope Failure." Jordan Journal of Civil Engineering 17, no. 1 (2023): 71–82. http://dx.doi.org/10.14525/jjce.v17i1.07.

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Permanent ground deformations (PGDs) induced by slope failures cause catastrophic damage to buried pipelines. This paper presents a 2D plane-strain numerical analysis of the behavior of a 800 mm water transport pipeline buried in the Aine-Tine slope (Mila, Algeria) subjected to shallow PGD, as it could be triggered by the recent earthquake of August 07th, 2020 (M= 4.9). The analysis is carried out through the application of an incremental displacement to simulate the soil-pipeline interaction while focusing on the effect of (1) the magnitude of the PGD and (2) the rigidity of the pipeline on t

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Pryzhkova, Marina, Xuan Yuan, Abhai Tripathi, David Sullivan, and Elias Zambidis. "Efficient Erythroid Differentiation of a PGD-Derived Human Pluripotent Stem Cell Line Affected with Sickle Cell Hemoglobinopathy." Blood 112, no. 11 (2008): 539. http://dx.doi.org/10.1182/blood.v112.11.539.539.

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Abstract The technology of preimplantation genetic diagnosis (PGD) screens IVF-derived cleavage-stage embryos or oocytes from parents with inherited disorders, and is routinely used to avoid births with severe genetic disorders. More than one hundred testable genetic conditions, including severe hematologic diseases such as beta thalassemia, sickle cell anemia, and Fanconi anemia can be PCR-screened from either a micro-manipulated blastomere, or a pre-fertilization ovarian polar body. Derivation of human embryonic stem cell (hESC) lines from diseased IVF blastocysts has recently been reported,

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Botkin, Jeffrey R. "Ethical Issues and Practical Problems in Preimplantation Genetic Diagnosis." Journal of Law, Medicine & Ethics 26, no. 1 (1998): 17–28. http://dx.doi.org/10.1111/j.1748-720x.1998.tb01902.x.

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Preimplantation genetic diagnosis (PGD) is a new method of prenatal diagnosis that is developing from a union of in vitro fertilization (IVF) technology and molecular biology. Briefly stated, PGD involves the creation of several embryos in vitro from the eggs and sperm of an interested couple. The embryos are permitted to develop to a 6-to-10-cell stage, at which point one of the embryonic cells is removed from each embryo and the cellular DNA is analyzed for chromosomal abnormalities or genetic mutations. An embryo or several embryos found to be free of genetic abnormalities are subsequently

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Frederiks, Wilma M., Klazina S. Bosch, Jonas S. S. G. De Jong, and Cornelis J. F. Van Noorden. "Post-translational Regulation of Glucose-6-phosphate Dehydrogenase Activity in (Pre)neoplastic Lesions in Rat Liver." Journal of Histochemistry & Cytochemistry 51, no. 1 (2003): 105–12. http://dx.doi.org/10.1177/002215540305100112.

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Glucose-6-phosphate dehydrogenase (G6PD; EC 1.1.1.49) is the key regulatory enzyme of the pentose phosphate pathway and produces NADPH and riboses. In this study, the kinetic properties of G6PD activity were determined in situ in chemically induced hepatocellular carcinomas, and extralesional and control parenchyma in rat livers and were directly compared with those of the second NADPH-producing enzyme of the pentose phosphate pathway, phosphogluconate dehydrogenase (PGD). Distribution patterns of G6PD activity, protein, and mRNA levels were also compared to establish the regulation mechanisms

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Tuddenham, Edward, Cathy Turner, Ben Lavender, Stuart Lavery, and Katerina Michaelides. "Live birth following the first mutation specific pre-implantation genetic diagnosis for haemophilia A." Thrombosis and Haemostasis 95, no. 02 (2006): 373–79. http://dx.doi.org/10.1160/th05-08-0574.

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SummaryHaemophilia A is an X-linked, recessive, inherited bleeding disorder which affects 1 in 5000 males born worldwide. It is caused by mutations in the FactorVIII (F8) gene on chromosome Xq28. We describe for the first time two mutation specific, single cell protocols for pre-implantation genetic diagnosis (PGD) of haemophilia A that enable the selection of both male and female unaffected embryos. This approach offers an alternative to sexing, frequently used for X-linked disorders, that results in the discarding of all male embryos including the 50% that would have been normal. Two familie

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Tulay, Pinar, Meral Gultomruk, Necati Findikli, Erbil Yagmur, and Mustafa Bahceci. "Is the interchromosomal effect present in embryos derived from Robertsonian and reciprocal translocation carriers particularly focusing on chromosome 10 rearrangements?" Zygote 23, no. 6 (2014): 908–15. http://dx.doi.org/10.1017/s0967199414000628.

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SummaryThe aim of this study was to analyse the possible occurrence of the interchromosomal effect (ICE) in human preimplantation embryos obtained from Robertsonian and reciprocal translocation carriers focusing on ones with chromosome 10 rearrangements who were undergoing preimplantation genetic diagnosis (PGD) and to investigate whether offering aneuploidy screening would be beneficial to these patients. Cleavage stage embryos from translocation carriers undergoing PGD were biopsied. Multicolour fluorescence in situ hybridisation for the chromosomes involved in the translocation in addition

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Trieu, Tien Sang, Van Khoa Tran, Van Phong Nguyen, Trong Tuan Le, and Van Hai Le. "A novel mutation on OCA2 gene detection and preimplantationgenetic diagnosis for oculocutaneous albinism type 2 (OCA2)." Ministry of Science and Technology, Vietnam 65, no. 7 (2023): 1–7. http://dx.doi.org/10.31276/vjst.65(7).01-07.

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Oculocutaneous albinism (OCA) is a group of recessive genetic congenital disorders characterised by a disorder of melanin synthesis. OCA is currently classified into seven different types, of which OCA type 2 (OCA2 - OMIM 203200) ranks as the second most common type of albinism in the world and accounts for nearly 30% of albinism cases. Nowadays, there is currently no known way to treat OCA. Preimplantation genetic diagnosis (PGD) is the most effective method of disease prevention, which helps families carrying gene mutations to have healthy children. Objectives: To develop a procedure and con

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Peura, Teija, Alexis Bosman, Omar Chami, Robert P. S. Jansen, Katka Texlova, and Tomas Stojanov. "Karyotypically Normal and Abnormal Human Embryonic Stem Cell Lines Derived from PGD-Analyzed Embryos." Cloning and Stem Cells 10, no. 2 (2008): 203–16. http://dx.doi.org/10.1089/clo.2007.0062.

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Udoff, L. C., M. Hughes, S. Munne, A. Wilcox, E. Lisa, and D. Carrell. "The availability of normal embryos for transfer is difficult to predict in PGD cycles." Fertility and Sterility 76, no. 3 (2001): S135. http://dx.doi.org/10.1016/s0015-0282(01)02397-4.

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Keskintepe, L., G. Sher, M. Ginsburg, M. Keskintepe, P. Okamoto, and J. Crowley. "A retrospective analysis of fish “normal” blastomeres in failed PGD cycles: a preliminary report." Fertility and Sterility 88 (September 2007): S237. http://dx.doi.org/10.1016/j.fertnstert.2007.07.809.

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Milross, Luke, Chelsea Griffiths, and Andrew J. Fisher. "Ex Vivo Lung Perfusion: A Platform for Donor Lung Assessment, Treatment and Recovery." Transplantology 2, no. 4 (2021): 387–95. http://dx.doi.org/10.3390/transplantology2040037.

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Lung transplantation offers a lifesaving therapy for patients with end-stage lung disease but its availability is presently limited by low organ utilization rates with donor lungs frequently excluded due to unsuitability at assessment. When transplantation does occur, recipients are then vulnerable to primary graft dysfunction (PGD), multitudinous short-term complications, and chronic lung allograft dysfunction. The decision whether to use donor lungs is made rapidly and subjectively with limited information and means many lungs that might have been suitable are lost to the transplant pathway.

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Gazzo Benavides, Eduardo, Gigliana Catanzaro Foppiano, Ernesto Escudero Velando, Federico Valdez León, Luis Noriega Hoces, and Soledad Sepúlveda. "Origen de las aneuploidías en blastocistos humanos, analizados por la técnica de polimorfismo de nucleotide único con Parental Support." Revista Peruana de Ginecología y Obstetricia 60, no. 1 (2014): 39–44. http://dx.doi.org/10.31403/rpgo.v60i108.

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Introducción: El diagnóstico genético preimplantacional (PGD) por medio de las técnicas de aCGH y polimorfismo de nucleótido único (SNPs - single nucleotide polymorphism) se ha convertido en una herramienta útil en los ciclos de reproducción asistida, superando al PGD por hibridación fluorescente in situ (FISH). Estas técnicas nos permiten conocer las aneuploidías en cada uno de los cromosomas. Además, la SNPs con Parental Support (Natera, Inc) posibilita conocer el origen de la aneuploidía en los blastocistos, si por el espermatozoide o por el ovocito. Objetivos: Determinar la tasa de aneuplo

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Shahnawaz, Maha Ahmed, Manahil Abbasi, and Imtiaz A. Abbasi. "A Rare Case of Partial Gonadal Dysgenesis (46,XY) from Pakistan." INNOVAPATH 2, Q2 (2025): 5. https://doi.org/10.63501/pjd76z66.

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46XY Partial gonadal dysgenesis(PGD) is a rare subset of disorders of sexual development (DSD).Diagnosing and managing such cases can be particularly challenging in resource-limited settingslike Pakistan. We present the case of a 17-year-old male with ambiguous genitalia andhypospadias. On presentation, he was diagnosed with perineal hypospadias, rudimentary blindending vagina, asymmetric testicular descent and a hypoplastic prostate. Hormonal testsrevealed high levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) and lowtestosterone, and imaging studies showed a normal bl

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DeUgarte, C. Marin, G. Ambartsumyan, M. Li, Y. Verlinsky, D. Hill, and A. DeCherney. "Successful Selection of Normal Embryos Using PGD in a Woman with Spinocerebellar Ataxia Type 3." Fertility and Sterility 83, no. 5 (2005): S30—S31. http://dx.doi.org/10.1016/j.fertnstert.2005.01.077.

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Zhan, Q., N. Zaninovic, and Z. Rosenwaks. "Karyotypically normal human embryonic stem cells (HESC) derived from aneuploid preimplantation genetic diagnosis (PGD) embryos." Fertility and Sterility 96, no. 3 (2011): S105. http://dx.doi.org/10.1016/j.fertnstert.2011.07.410.

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Ghnatios, Chady, Anais Barasinski, and Francisco Chinesta. "On the High-Resolution Discretization of the Maxwell Equations in a Composite Tape and the Heating Effects Induced by the Dielectric Losses." Computation 10, no. 2 (2022): 24. http://dx.doi.org/10.3390/computation10020024.

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Electromagnetic field propagation inside composite materials represents a challenge where fiber-scale simulation remains intractable using classical simulation methods. The present work proposes an original 3D simulation with a mesh resolution fine enough to resolve the fiber scale, thanks to the use of Proper Generalized Decomposition (PGD)-based space decomposition, which avoids the necessity of considering homogenized properties and considers the richest description of the involved physics from the solution of the Maxwell equations. This high-resolution simulation enables comparing the elec

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Grewal, Satkiran S., Jeffrey P. Kahn, Margaret L. MacMillan, Norma K. C. Ramsay, and John E. Wagner. "Successful hematopoietic stem cell transplantation for Fanconi anemia from an unaffected HLA-genotype–identical sibling selected using preimplantation genetic diagnosis." Blood 103, no. 3 (2004): 1147–51. http://dx.doi.org/10.1182/blood-2003-02-0587.

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AbstractThe only proven cure for Fanconi anemia (FA)-associated bone marrow failure is successful allogeneic hematopoietic stem cell transplantation (HSCT). However, HSCT with donors other than HLA-identical siblings is associated with high morbidity and poor survival. Therefore, we used preimplantation genetic diagnosis (PGD) to select an embryo produced by in vitro fertilization (IVF) that was unaffected by FA and was HLA-identical to the proband. The patient was a 6-year-old girl with FA and myelodysplasia previously treated with oxymetholone and prednisone. After her parents underwent 5 cy

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Namwong, A., P. Jitsangiam, and T. Tanchaisawat. "Evaluation of reduced-scale railway ballast particle size effects for different test sample sizes using monotonic triaxial tests." IOP Conference Series: Earth and Environmental Science 1332, no. 1 (2024): 012014. http://dx.doi.org/10.1088/1755-1315/1332/1/012014.

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Abstract This study rigorously investigated the mechanical characteristics of railway ballast using largescale triaxial (LST) testing, focusing on shear strength, stress–strain relationships, and volumetric alterations by altering particle sizes under controlled conditions. Samples with a size ratio (D/dmax) of 4.7 are typically used in LST testing. However, the ballast used in Thailand typically features a maximum grain size of 70.00 mm, whereas LST testing requires samples with diameter exceeding 300 mm, which poses logistical and material challenges. To mitigate this issue, our test introdu

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Correia De Sá, Z., B. Castro Sousa, and J. Ramos. "Grief in modern multicultural Europe – a way out of “disenfranchisement”." European Psychiatry 67, S1 (2024): S523. http://dx.doi.org/10.1192/j.eurpsy.2024.1087.

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IntroductionThe recent addition to both ICD-11 and DSM-V of “Prolonged Grief Disorder” “PGD” raises questions regarding the complexity of the clinical manifestations and the nuances of “normal/abnormal” grief. The lack of consensus in diagnosing emphasizes grief as a non-homogeneous process highly dependent on cultural nuances and the proportion of losses.ObjectivesProvide an open discourse on (PGD) emphasizing its multicultural aspects in the diagnosis, and debate whether it reinforces mental health stigma by “pathologizing” grief in today’s multicultural society.MethodsNon-systematic review

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Fang, Jin, Caijun Xu, Jianfei Zang, Yangmao Wen, Chuang Song, and Yanyan Li. "Application of high-rate GPS for earthquake rapid response and modelling: a case in the 2019 Mw 7.1 Ridgecrest earthquake." Geophysical Journal International 222, no. 3 (2020): 1923–35. http://dx.doi.org/10.1093/gji/ggaa272.

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SUMMARY The 2019 Mw 7.1 Ridgecrest earthquake opens an opportunity to investigate how soon we can produce a reliable fault geometry and subsequently a robust source model based on high-rate Global Positioning System (GPS) data. In this study, we conduct peak ground displacement (PGD) magnitude scaling, real-time centroid moment tensor (CMT) calculation and rapid kinematic slip inversion. We conclude that a four-station PGD warning with a magnitude of Mw 7.03 can be issued at 24 s after initiation of the rupture. Fast CMT inversion can initially recover the correct nodal planes at 30 s. The kin

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Wenslaff, Timothy F., and Paul M. Lyrene. "TETRASOMIC INHERITANCE OF ISOZYME AND PHENOTYPIC MARKERS IN ALLOTETRAPLOID BLUEBERRIES." HortScience 27, no. 6 (1992): 657e—657. http://dx.doi.org/10.21273/hortsci.27.6.657e.

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A study was done to test whether inheritance is tetrasomic or disomic in tetraploid Fl hybrids between 2x Vaccinium elliottii Chapm. and 4x V. corymbosum L. Seventeen Fl hybrids derived from V. elliottii homozygous for recessive anthocyanin deficiency (AD) were confirmed by isozyme analysis and, where V. elliottii was the seed parent, by the presence of anthocyanin. Fertile hybrids with high pollen stainability were assumed to be 4x and duplex for the AD allele, having arisen from 2n gametes in V. elliottii. In nine Fl × Fl crosses, all progeny populations segregated for AD phenotype at or abo

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Gabriel Ribeiro de Andrade, Juliana, Antonia Paula Marques-de-Faria, Helena Campos Fabbri, Maricilda Palandi de Mello, Gil Guerra-Júnior, and Andréa Trevas Maciel-Guerra. "Long-Term Follow-Up of Patients with 46,XY Partial Gonadal Dysgenesis Reared as Males." International Journal of Endocrinology 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/480724.

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Background/Aims. Studies on 46,XY partial gonadal dysgenesis (PGD) have focused on molecular, gonadal, genital, and hormone features; little is known about follow-up. Our aim was to analyze long-term outcomes of PGD.Methods. Retrospective longitudinal study conducted at a reference service in Brazil. Ten patients were first evaluated in the 1990s and followed up until the 2010s; follow-up ranged from 13.5 to 19.7 years. All were reared as males and had at least one scrotal testis; two boreNR5A1mutations. Main outcomes were: associated conditions, pubertal development, and growth.Results. All p

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Dubey, A. K., M. Dayal, D. Peak, R. Khaldi, D. Frankfurter, and P. Gindoff. "Prefered day of embryo transfer (day 4 vs day 5) of normal PGD embryos depends on develpomental stage." Fertility and Sterility 94, no. 4 (2010): S127. http://dx.doi.org/10.1016/j.fertnstert.2010.07.514.

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Simón, C., C. Rubio, F. Vidal, et al. "Increased chromosome abnormalities in human preimplantation embryos after in-vitro fertilization in patients with recurrent miscarriage." Reproduction, Fertility and Development 10, no. 1 (1998): 87. http://dx.doi.org/10.1071/r98030.

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Recurrent miscarriage is a pathological condition induced by maternal and embryonic causes. This paper describes a prospective study to determine the real incidence of aneuploidy for autosomes 13, 16, 18, 21, 22, and gonosomes in preimplantation human embryos obtained from patients with recurrent pregnancy loss after ovarian stimulation in an IVF-ET programme. Our results indicate that aneuploidy for the chromosomes analysed are abnormally higher in embryos obtained after IVF from recurrent abortion patients (58%) compared to non-recurrent abortion patients undergoing IVF. Furthermore, monosom

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Akram, M. Rizwan, Ali Yesilyurt, A. Can Zulfikar, and F. Göktepe. "Failure Analysis Of Buried Gas Pipelines Crossing Seismic Faults." Academic Perspective Procedia 3, no. 2 (2020): 781–90. http://dx.doi.org/10.33793/acperpro.03.02.2.

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Research on buried gas pipelines (BGPs) has taken an important consideration due to their failures in recent earthquakes. In permanent ground deformation (PGD) hazards, seismic faults are considered as one of the major causes of BGPs failure due to accumulation of impermissible tensile strains. In current research, four steel pipes such as X-42, X-52, X-60, and X-70 grades crossing through strike-slip, normal and reverse seismic faults have been investigated. Firstly, failure of BGPs due to change in soil-pipe parameters have been analyzed. Later, effects of seismic fault parameters such as ch

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Chung, Jin Tae, Weon-Young Son, Xiao Yun Zhang, Asangla Ao, Seang Lin Tan, and Hananel Holzer. "Normal birth following PGD for reciprocal translocation after serial vitrification of oocytes from a poor responder: a case report." Reproductive BioMedicine Online 25, no. 5 (2012): 521–26. http://dx.doi.org/10.1016/j.rbmo.2012.07.017.

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Tanaka, A., M. Nagayoshi, S. Awata, I. Tanaka, H. Kusunoki, and S. Watanabe. "A new assay system for distinction between a balanced translocation and a normal karyotype in preimplantation genetic diagnosis (PGD)." Fertility and Sterility 92, no. 3 (2009): S50. http://dx.doi.org/10.1016/j.fertnstert.2009.07.195.

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N’koua, S. E., S. Rafi, G. El Mghari, and N. El Ansari. "A Rare Cause of Primary Amenorrhea: Swyer's Syndrome: A Case Report." Scholars Journal of Medical Case Reports 10, no. 2 (2022): 171–73. http://dx.doi.org/10.36347/sjmcr.2022.v10i02.032.

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Swyer syndrome is defined as pure XY gonadal dysgenesis (PGD). The phenotype is unequivocally female with a clinical history of primary amenorrhea and impuberty. We present a case of primary amenorrhea for which the etiological investigation revealed a 46XY karyotype. The patient was 34 years old and was admitted to the hospital for the development of primary amenorrhoea. On clinical examination, the patient had an adult female morphotype with a normal vulva. Hormonal work-up revealed hypogonado-hypergonadotropic, pelvic MRI: showed normal vagina and uterus with bilateral hypotrophic ovaries w

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Metternick-Jones, Selina. "Choosing Impairment: Conflicting Interests." QUT Law Review 18, no. 2 (2019): 229. http://dx.doi.org/10.5204/qutlr.v18i2.769.

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The integration of reproductive genetic testing into clinical care presents both opportunities and challenges for parents in regards to shaping the lives of their future children. The relationship between parents and their future children has become more complex and new questions are being raised in relation to the extent of parental responsibility to future generations. This paper explores the ethical permissibility of using pre-implantation genetic diagnosis (PGD) to select for impairment, through the use of two case studies involving identity-affecting decisions. Through analysing harm usin

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Griffin, Darren, and Çağri Oğur. "PGS: a four-letter word?" Biochemist 40, no. 3 (2018): 26–32. http://dx.doi.org/10.1042/bio04003026.

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Preimplantation genetic screening (PGS) involves the identification of chromosome abnormalities in IVF embryos (rather than targeting diagnosis to a specified gene). Chiefly employed for couples with advanced maternal age, recurrent miscarriage or recurrent IVF failure, it aims to improve IVF success, and reduce miscarriage and affected live birth rates. The process involves the sampling of cells by embryo biopsy, cytogenetic diagnosis, then selective transfer of an apparently chromosomally normal embryo in the hope of establishing a pregnancy. Although PGS is the most common variant of PGD (p

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Snyder, Thomas P., Dale A. Stewart, and Ann F. Strickler. "Temporal analysis of breeding structure in jack pine (Pinusbanksiana Lamb.)." Canadian Journal of Forest Research 15, no. 6 (1985): 1159–66. http://dx.doi.org/10.1139/x85-188.

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Outcrossing rates for 10 pollination years were estimated for a natural stand of jack pine using allozymic markers at the Mdh-2 and 6-pgd-1 loci. Outcrossing rate estimates showed a general increase with time since pollination. Population fixation index values for the progeny decrease with time since pollination, showing an increasing proportion of heterozygous progeny. These increases parallel those observed for jack pine, lodgepole pine, and alpine ash by other investigators, suggesting selection against inbred progeny may be occurring during the retention of the seed in the serotinous cones

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O'Shaughnessy, Peter J., Heather Johnston, Louise Willerton, and Paul J. Baker. "Failure of normal adult Leydig cell development in androgen-receptor-deficient mice." Journal of Cell Science 115, no. 17 (2002): 3491–96. http://dx.doi.org/10.1242/jcs.115.17.3491.

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During testicular development, fetal and adult populations of Leydig cells arise sequentially. Previous studies have shown that androgen action is required for normal steroidogenic activity in the mouse testis. Therefore, to determine the role of androgens in regulating fetal and adult Leydig cell differentiation and function, Leydig development has been measured in mice lacking functional androgen receptors (AR-null). The Leydig cell number was normal on day 5 after birth in AR-null mice but failed to increase normally thereafter and was about 30% of the control level on day 20 and about 60%

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Verma, S., R. Shah, A. Bhat, GR Bhat, R. Dada, and R. Kumar. "A familial case report of a 13;22 chromosomal translocation with recurrent intracytoplasmic sperm injection failure." Balkan Journal of Medical Genetics 21, no. 2 (2018): 73–77. http://dx.doi.org/10.2478/bjmg-2018-0017.

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Abstract The importance of cytogenetic analysis in a family with reproductive failure in two siblings is highlighted, where two siblings and their mother presented with a balanced translocation between chromosomes 13;22. The clinical evaluation had shown the female to be normal and the male to be oligoasthenoteratozoospermic despite repeated semen analysis. The couple was referred to our laboratory after three consecutive intracytoplasmic sperm injection (ICSI) failures at a local assisted reproductive technique (ART) center. Peripheral blood lymphocytes, obtained for karyotyping, were studied

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Obasaju, M. F., A. Kadam, T. Biancardi, M. Fateh, and K. Sultan. "Pregnancy Rate from the Transfer of a Single Normal Embryo in Women of Advanced Reproductive Age Undergoing PGD for Determination of Aneuploidy." Fertility and Sterility 74, no. 3 (2000): S18. http://dx.doi.org/10.1016/s0015-0282(00)00772-x.

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Wang, Guohua, and Qifan Yan. "A Method for Improving the Robustness of Intrusion Detection Systems Based on Auxiliary Adversarial Training Wasserstein Generative Adversarial Networks." Electronics 14, no. 11 (2025): 2171. https://doi.org/10.3390/electronics14112171.

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To improve the robustness of intrusion detection systems constructed using deep learning models, a method based on an auxiliary adversarial training WGAN (AuxAtWGAN) is proposed from the defender’s perspective. First, one-dimensional traffic data are downscaled and processed into two-dimensional image data via a stacked autoencoder (SAE), and mixed adversarial samples are generated using the fast gradient sign method (FGSM), Projected Gradient Descent (PGD) and Carlini and Wagner (C&W) adversarial attacks. Second, the improved WGAN with an integrated perceptual network module is trained wi

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Bhavna, Saini*1 &. Prof. Satish Parihar2. "REACTION OF VARIOUS VIBRATIONAL MOTIONS." INTERNATIONAL JOURNAL OF ENGINEERING SCIENCES & RESEARCH TECHNOLOGY 7, no. 6 (2018): 68–74. https://doi.org/10.5281/zenodo.1260399.

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Structural dynamic is a mandatory graduate level course for structural engineering student all around the world. In civil engineering buildings are mostly designed based on prescriptive methods of standard codes. Usually loads on these buildings are of low magnitude which results in elastic structural behavior. However, strong loads such as a sudden earthquake will lead the building beyond its elastic limit. Generally 4 kinds of earthquake ground motions are considered such as Fault Normal, Fault Parallel, Near Fault and Far Fault components. In the current study the performance of a building

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Perrimon, Norbert, Lee Engstrom, and Anthony P. Mahowald. "DEVELOPMENTAL GENETICS OF THE 2C-D REGION OF THE DROSOPHILA X CHROMOSOME." Genetics 111, no. 1 (1985): 23–41. http://dx.doi.org/10.1093/genetics/111.1.23.

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ABSTRACT We have conducted a genetic and developmental analysis of genes within the 2C-D area of the X chromosome. Phenotypes of 33 mutations representing nine adjacent complementation groups including eight recessive lethals and one visible homeotic mutation (polyhomeotic) are described. Germline clonal analysis of the eight zygotic lethals has revealed three types of gene requirements: (1) normal activity at two pupal lethal loci (corkscrew and C204) and one larval lethal locus (ultraspiracle) is required for normal embryogenesis; (2) normal activity at three larval lethal loci (DF967, VE651

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Leonart, Maria Sueli Soares, Aguinaldo José Nascimento, Kimiyo Nonoyama, Cinthia Barbosa Pelissari, and Orlando Cesar de Oliveira Barretto. "Enzymes and membrane proteins of ADSOL-preserved red blood cells." Sao Paulo Medical Journal 118, no. 2 (2000): 41–45. http://dx.doi.org/10.1590/s1516-31802000000200003.

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CONTEXT: The preservative solution ADSOL (adenine, dextrose, sorbitol, sodium chloride and mannitol) maintains red cell viability for blood trans-fusion for 6 weeks. It would be useful to know about its preservation qualities over longer periods. OBJECTIVE: To determine some red cell biochemical parameters for peri-ods of up to 14 weeks in order to determine whether the red cell metabo-lism integrity would justify further studies aiming at increasing red cell preservation and viability. DESIGN: Biochemical evaluation designed to study red cell preservation. SETTING: São Paulo University erythr

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Wójcik, Piotr, Neven Žarković, Agnieszka Gęgotek, and Elżbieta Skrzydlewska. "Involvement of Metabolic Lipid Mediators in the Regulation of Apoptosis." Biomolecules 10, no. 3 (2020): 402. http://dx.doi.org/10.3390/biom10030402.

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Apoptosis is the physiological mechanism of cell death and can be modulated by endogenous and exogenous factors, including stress and metabolic alterations. Reactive oxygen species (ROS), as well as ROS-dependent lipid peroxidation products (including isoprostanes and reactive aldehydes including 4-hydroxynonenal) are proapoptotic factors. These mediators can activate apoptosis via mitochondrial-, receptor-, or ER stress-dependent pathways. Phospholipid metabolism is also an essential regulator of apoptosis, producing the proapoptotic prostaglandins of the PGD and PGJ series, as well as the an

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