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Bibliographies thématiques / PML-RARA, LAMP, APL

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Littérature scientifique sur le sujet « PML-RARA, LAMP, APL »

Auteur : Grafiati

Publié le 9 mars 2023

Mis à jour le 31 juillet 2025

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Articles de revues sur le sujet "PML-RARA, LAMP, APL"

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Jang, Heejun, Sungyoung Lee, Hongseok Yun, Yongil Koh, and Sung-Soo Yoon. "Abstract 3359: Association of Hippo signaling pathway in acute myeloid leukemia." Cancer Research 82, no. 12_Supplement (2022): 3359. http://dx.doi.org/10.1158/1538-7445.am2022-3359.

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Abstract The Hippo signaling pathway, also known as the Salvador-Warts-Hippo pathway, is a well-known oncogenic signaling pathway associated with organ size regulation, cell proliferation, and apoptosis. In this study, we analyzed the association of Hippo signaling pathway genes in patients with acute myeloid leukemia (AML) using whole-exome sequencing (WES) and whole-transcriptome sequencing (WTS) data. We used Seoul National University Hospital (SNUH) AML patient data (n=16) collected from December 2015 to January 2019 for analysis. Additionally, public datasets of AML patients, TCGA-LAML (n

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Roug, Anne Stidsholt, Hanne Oestergaard Larsen, Hans Beier Ommen, and Peter Hokland. "Sensitivity of MRD Detection in AML: qPCR Vs. MFC - a Plethora to Choose From, but Which Is Best?" Blood 118, no. 21 (2011): 1447. http://dx.doi.org/10.1182/blood.v118.21.1447.1447.

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Abstract Abstract 1447 Background: There is a growing realization that outcome of acute myeloid leukemia (AML) is strongly correlated to whether minimal residual disease (MRD) - as quantified by either multicolor flow cytometry (MFC) or real-time quantitative polymerase chain reaction (qPCR) - is demonstrable at crucial clinical decision time points. While FCM is applicable in up to 95% of all cases through the detection of leukemia-associated immunophenotypes (LAIPs), its major drawback is the lack of sensitivity in most cases and antigen shift, which is seen in up to 20% of cases. In contras

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Kern, Wolfgang, Claudia Schoch, Torsten Haferlach, Daniela Voskova, Wolfgang Hiddemann, and Susanne Schnittger. "Minimal Residual Disease in Patients with Acute Myeloid Leukemia Quantified by Multiparameter Flow Cytomety and Quantitative RT-PCR Is an Independent Prognostic Parameter." Blood 104, no. 11 (2004): 319. http://dx.doi.org/10.1182/blood.v104.11.319.319.

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Quantification of minimal residual disease (MRD) is becoming increasingly important to guide therapy in patients with acute myeloid leukemia (AML). While MFC can be applied to more patients with AML than QPCR, the latter has the advantage of a higher sensitivity in many cases. We compared data obtained by both methods in parallel in bone marrow samples in 160 patients at diagnosis and at 469 follow-up checkpoints. MFC was applied at diagnosis with a comprehensive panel of antibodies to identify leukemia-associated aberrant immunophenotypes (LAIP) useful for MRD monitoring. QPCR targeted on the

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Karathedath, Sreeja, Sukanya Ganesan, Wei Zhang, et al. "Expression Profiling Of Nuclear Hormone Receptors In Myeloid Leukemia Reveals Potential Novel Drug Targets For Combination Therapy." Blood 122, no. 21 (2013): 3855. http://dx.doi.org/10.1182/blood.v122.21.3855.3855.

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Abstract Nuclear Hormone Receptors (NHRs) are a large superfamily of ligand dependent transcription factors regulating a plethora of genes involved in metabolism, growth and differentiation. Recent studies identified the overwhelming role played by NHR in determining hematopoiesis as well as HSC function and fate, suggesting that defective proliferation and maturation of progenitors in hematopoietic malignancies could be attributed to altered expression of these transcriptional regulators. NHRs are attractive but relatively unexplored drug targets and there is limited data on their expression

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Maity, Akash, Amritha Sathyanarayanan, Rohit Kumar, et al. "RAPID-CRISPR: Highly Sensitive Diagnostic Assay for Detection of PML-RARA Isoforms in Acute Promyelocytic Leukemia." Blood Advances, December 2, 2024. https://doi.org/10.1182/bloodadvances.2024014539.

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Acute promyelocytic leukemia (APL), distinguished by the presence of PML-RARA fusion transcript, is a medical emergency due to its high early death rate, which is preventable when diagnosed early. Current diagnostic methods are precise and reliable but are time-intensive, require sophisticated instruments and analytical expertise. This study has Redefined APL IDentification by CRISPR system (RAPID-CRISPR) to rapidly (&lt;3hrs) detect PML-RARA. APL cell lines (NB4 and UF-1) and bone marrow/peripheral blood samples from 74 APL patients (66/8 retrospective/prospective) and 48 controls were in

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Kramer, Michael H., Qiang Zhang, Robert Sprung, et al. "Proteomic and Phosphoproteomic Landscapes of Acute Myeloid Leukemia." Blood, July 27, 2022. http://dx.doi.org/10.1182/blood.2022016033.

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We have developed a deep-scale proteome and phosphoproteome database from 44 representative Acute Myeloid Leukemia (AML) patients from the LAML TCGA dataset, and 6 healthy bone marrow derived controls. After confirming data quality, we orthogonally validated several previously undescribed features of AML revealed by the proteomic data. We identified examples of post-transcriptionally regulated proteins both globally (i.e. in all AML samples), and also, in patients with recurrent AML driver mutations. For example, samples with IDH1/2 mutations displayed elevated levels of the 2‑oxoglutarate-dep

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Thèses sur le sujet "PML-RARA, LAMP, APL"

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RIGO, FRANCESCA. "Development of a Novel Molecular Assay for the Ultra-Rapid Diagnosis of Acute Promyelocytic Leukemia by RT-Q-LAMP Technology." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2016. http://hdl.handle.net/10281/103093.

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Acute promyelocytic leukemia (APL) accounts for 10% of cases of acute myeloid leukemia and is characterized by a particularly aggressive disease progression. Its peculiarity is the presence at diagnosis, 80% of cases, of a severe hemorrhagic syndrome. This dysfunction is often manifested in the form of hemorrhage at brain level that, before the advent of the revolutionary therapy with ATRA (All-Trans Retinoic Acid) caused the early death of almost 20% of patients. At the genetic level, the disease is caused in 99% of cases by

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