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Articles de revues sur le sujet « Potentiality vs. actuality »

Auteur : Grafiati

Publié le 7 juin 2025

Mis à jour le 2 août 2025

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Koslicki, Kathrin. "Essentialism vs. Potentialism: Allies or Competitors?" Philosophisches Jahrbuch 129, no. 2 (2022): 325–38. http://dx.doi.org/10.5771/0031-8183-2022-2-325.

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Do essence-based accounts of necessity and Vetter’s potentiality-based account of possibility in fact lead to the same result, viz., a single derived notion of necessity that is interdefinable with possibility or vice versa? And does each approach independently have the ability to reach its desired goal without having to rely on the primitive notion utilized by the other? In this essay, I investigate these questions and Vetter’s responses to them. Contrary to the “separatist” position defended by Vetter, I argue that there are reasons to favor “Combination”, according to which an essence-based

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Zvonareva, Olga, and Arturs Holavins. "Reflections on fluidity and stability: a look at the formality vs informality debate." International Journal of Sociology and Social Policy 43, no. 13/14 (2023): 183–93. http://dx.doi.org/10.1108/ijssp-05-2023-0112.

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PurposeThe distinction between formality and informality has been a topic central for many scholarly fields. Without rejecting the usefulness of this distinction, the authors argued that instead of analyzing an empirical situation in terms of what is formal and what is informal, it could sometimes be fruitful to focus on what is stable and what is fluid.Design/methodology/approachThis paper reports the results of review and analysis of secondary sources on the distinction between formality and informality, followed by a conceptualization of an alternative distinction between fluidity and stabi

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Ishola, David, Bailah Leigh, Emma Hancox, et al. "Need for Local Laboratory Reference Values in Recruitment into Studies of Emerging Infectious Diseases: Insight from Participant Screening for an Ebola Vaccine Trial in a Rural African Setting." Proceedings 45, no. 1 (2020): 8. http://dx.doi.org/10.3390/proceedings2020045008.

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Introduction: The EBOVAC-Salone trial of a candidate Ebola two-dose vaccine regimen (Ad.ZEBOV/MVA-BN-Filo) was conducted in a research-naïve setting in rural northern Sierra Leone, where no local laboratory reference values (LRV) had been established. In the first stage (n = 43) of the trial, laboratory screening was based on internationally-derived protocol LRV (PLRV). For postrecruitment participant care, LRV derived from a West African population (WALRV) were used. We assessed what difference using WALRV rather than PLRV for screening might have made to the eligibility of volunteers. METHOD

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Singhal, Kahira. "EVALUATING THE ECONOMIC VIABILITY OF HIGH-QUALITY PLASTICS VS. RECYCLABLE PLASTICS: AN IN-DEPTH ANALYSIS OF MONETARY GAIN." International Journal of Social Science & Economic Research 09, no. 02 (2024): 493–99. http://dx.doi.org/10.46609/ijsser.2024.v09i02.010.

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The economic viability of high-quality plastics versus recyclable plastics involves various factors. High- quality plastics often provide better performance than recyclable plastics, but it is also costlier due to their production processes and materials. Recyclable plastics. They are cheaper production. They lower durability or performance. Economic viability requires considering multiple aspects like production costs, market demands, environmental impact, recycling, infrastructure, regulations, and end-user preferences. Recycled plastics, often contain higher levels of chemicals such as toxi

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Janzic, Urska, Zala Rus, and Lea Knez. "Different dosing strategies of pembrolizumab in the treatment of NSCLC: A real-world retrospective observational study." Journal of Clinical Oncology 42, no. 16_suppl (2024): e23264-e23264. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e23264.

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e23264 Background: Immune checkpoint inhibitors lack a dose-response relationship, allowing optimisation of dosing strategies that may reduce drug use. Pembrolizumab received its initial regulatory approval for the treatment of non-small cell lung cancer (NSCLC) at weight-based dosing (2 mg/kg every 3 weeks (Q3W)), as employed in pivotal clinical trials demonstrating its efficacy and safety. This dosing regimen was later replaced by the currently approved flat-dosing (200 mg Q3W or 400 mg Q6W) in all indications, potentially increasing drug use. This retrospective observational study evaluates

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Lin, Yu-Ting, Deborah J. MacInnis, and Andreas B. Eisingerich. "Strong Anxiety Boosts New Product Adoption When Hope Is Also Strong." Journal of Marketing 84, no. 5 (2020): 60–78. http://dx.doi.org/10.1177/0022242920934495.

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New products can evoke anticipatory emotions such as hope and anxiety. On the one hand, consumers might hope that innovative offerings will produce goal-congruent outcomes; on the other hand, they might also be anxious about possible outcomes that are goal-incongruent. The authors demonstrate the provocative and counterintuitive finding that strong anxiety about potentially goal-incongruent outcomes from a new product actually enhances (vs. weakens) consequential adoption intentions (Study 1) and actual adoption (Studies 2 and 3) when hope is also strong. The authors test action planning (a fo

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Ding, Qing, and David Rothstein. "Plasma cells are not necessary for regulatory B cells and preventing their differentiation markedly prolongs allograft survival." Journal of Immunology 204, no. 1_Supplement (2020): 87.13. http://dx.doi.org/10.4049/jimmunol.204.supp.87.13.

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Abstract Plasma Cells produce Abs. Recently, PCs were reported to be the major source of B-cell IL-10, and absence of PCs worsened EAE, implying that PCs underlie “Breg” activity. To test the hypothesis in transplantation, we transplanted Bc islets into chemically diabetic B6 Blimp-1fl/flCD19-Cre+/− (PCKO) mice. Surprisingly, allograft survival (GS) was prolonged by ~42% in untreated PCKO vs. Cre-neg Ctl recipients (Mean GS: 27 vs. 19d; p&lt;0.05). This prompted us to re-examine the EAE model where the regulatory role of PCs was first identified. Surprisingly, in our hands, the severity of

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Imberti, Jacopo F., Anna Maisano, Francesca Rampini, et al. "Cardiovascular Reasons for Access to a Tertiary Oncological Emergency Service: The CARILLON Study." Journal of Clinical Medicine 12, no. 3 (2023): 962. http://dx.doi.org/10.3390/jcm12030962.

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Background: The prevalence of acute cardiovascular diseases (CVDs) in cancer patients is steadily increasing and represents a significant reason for admission to the emergency department (ED). Methods: We conducted a prospective observational study, enrolling consecutive patients with cancer presenting to a tertiary oncological ED and consequently admitted to the oncology ward. Two groups of patients were identified based on main symptoms that lead to ED presentation: symptoms potentially related to CVD vs. symptoms potentially not related to CVD. The aims of the study were to describe the pre

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Tucci, Alessandra, Chiara Bottelli, Samantha Ferrari, Erika Borlenghi, Monica Drera, and Giuseppe Rossi. "A Comprehensive Geriatric Assessment Is More Effective Than Clinical Judgement to Prospectively Identify Elderly Patients with Diffuse Large Cell Lymphoma Who Can Tolerate Full-Dose Anthracyclin-Based Treatment and Achieve the Same Outcome as Young Patients." Blood 110, no. 11 (2007): 3441. http://dx.doi.org/10.1182/blood.v110.11.3441.3441.

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Abstract Introduction: Defining the optimal treatment strategy for elderly patients (pts) with diffuse large cell lymphoma (DLCL) represents a major challenge, since age, end-organ damage and comorbidities often preclude the delivery of full-dose intensive therapy. Objective means to prospectively identify those pts who can be safely treated with a curative intent are still lacking. We have analysed the performance of a comprehensive geriatric assessment (CGA) in defining those elderly DLCL pts which could tolerate an intensive and potentially curative treatment approach. Methods: In addition

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Pioche, Mathieu, Christell Ganne, Rodica Gincul, et al. "Colon capsule versus computed tomography colonography for colorectal cancer screening in patients with positive fecal occult blood test who refuse colonoscopy: a randomized trial." Endoscopy 50, no. 08 (2018): 761–69. http://dx.doi.org/10.1055/s-0044-100721.

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Abstract Objective Some patients (10 % – 32 %) with a positive guaiac fecal occult blood test (gFOBT) do not undergo the recommended colonoscopy. The aim of this study was to compare video capsule endoscopy (VCE) and computed tomography colonography (CTC) in terms of participation rate and detection outcomes when offered to patients with a positive gFOBT who did not undergo the recommended colonoscopy. Methods An invitation letter offering CTC or VCE was sent to selected patients after randomization. Acceptance of the proposed (or alternative) procedure and procedure results were recorded. Sam

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Pervichko, E., and Y. Zinchenko. "Rosenzweig picture-frustration test modification for a study of emotion regulation strategies among the patients with stress-induced hypertension." European Psychiatry 33, S1 (2016): S571. http://dx.doi.org/10.1016/j.eurpsy.2016.01.2115.

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IntroductionEmotion regulation (ER) efficiency dwells among the most pressing issues of contemporary psychology and psychiatry. Further development of the methods of reliable assessments for ER makes it the task of current importance.ObjectiveTo modify Rosenzweig Picture-Frustration Test for the study of ER in health and in disease.MethodsIn the initial stage of testing participants had to look through a succession of Rosenzweig's pictures, and select potentially traumatizing situations.In the second stage they answered the following questions:– what would you say in this particular situation?

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Magurno, Amy Barlow, and Michael S. Wogalter. "Behavioral Compliance with Warnings: Effects of Stress and Placement." Proceedings of the Human Factors and Ergonomics Society Annual Meeting 38, no. 14 (1994): 826–30. http://dx.doi.org/10.1177/154193129403801406.

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Research on the effectiveness of warnings has tended to focus on internal design aspects including variables such as the inclusion of various pictorials, color, and signal words. Only a few studies have examined the influence of warning-related variables that are external to the design of the warning itself although there have been some exceptions such as research on the effects of social influence and cost of compliance. Another potentially important external factor with respect to warning effectiveness is stress. Stress has been shown to influence the quality of decision-making and judgment

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Patel, Anika. "Evaluating the Efficacy of Peer and Teacher Feedback on Writing Development among Secondary Students in Bologna, Italy." Research Studies in English Language Teaching and Learning 2, no. 2 (2024): 106–15. http://dx.doi.org/10.62583/rseltl.v2i2.43.

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The study aims to undertake an investigation regarding the different effect of teacher vs. peer feedback on varied sections of writing proficiency among secondary students in Bologna, Italy. The research employed a structured questionnaire to a sample of 150 students in an inquiry that sought to establish the effectiveness of these feedback modalities in enhancing writing tasks. The analysis was also supported by SPSS, which helped in reaching a comprehensive understanding of the dynamics within feedback. The results provide a much more nuanced picture in which peer feedback, under certain con

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Huang, Weiwei, David Ratkowsky, Cang Hui, Ping Wang, Jialu Su, and Peijian Shi. "Leaf Fresh Weight Versus Dry Weight: Which is Better for Describing the Scaling Relationship between Leaf Biomass and Leaf Area for Broad-Leaved Plants?" Forests 10, no. 3 (2019): 256. http://dx.doi.org/10.3390/f10030256.

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Leaf dry mass per unit area (LMA) is considered to represent the photosynthetic capacity, which actually implies a hypothesis that foliar water mass (leaf fresh weight minus leaf dry weight) is proportional to leaf dry weight during leaf growth. However, relevant studies demonstrated that foliar water mass disproportionately increases with increasing leaf dry weight. Although scaling relationships of leaf dry weight vs. leaf area for many plants were investigated, few studies compared the scaling relationship based on leaf dry weight with that based on leaf fresh weight. In this study, we used

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Tudor-Locke, Catrine, Cora L. Craig, John P. Thyfault, and John C. Spence. "A step-defined sedentary lifestyle index: <5000 steps/day." Applied Physiology, Nutrition, and Metabolism 38, no. 2 (2013): 100–114. http://dx.doi.org/10.1139/apnm-2012-0235.

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Step counting (using pedometers or accelerometers) is widely accepted by researchers, practitioners, and the general public. Given the mounting evidence of the link between low steps/day and time spent in sedentary behaviours, how few steps/day some populations actually perform, and the growing interest in the potentially deleterious effects of excessive sedentary behaviours on health, an emerging question is “How many steps/day are too few?” This review examines the utility, appropriateness, and limitations of using a reoccurring candidate for a step-defined sedentary lifestyle index: <500

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Borlenghi, Erika, Lorenzo Masina, Marco Frigeni, et al. "SIE/Sies/GITMO Criteria in Elderly Patients with Acute Myeloid Leukemia (AML): Useful Also in the New Drug Era? a Multicentric Real-Life Study By the Hematological Network Rete Ematologica Lombarda (REL)." Blood 142, Supplement 1 (2023): 956. http://dx.doi.org/10.1182/blood-2023-180568.

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Introduction: In elderly acute myeloid leukemia (AML) patients (pts) the debate about the use of intensive chemotherapy (iC) as opposed to non-intensive therapy (niT) or best supportive care (BSC) is a hot topic, particularly after the introduction of venetoclax (VEN) use. Age, comorbidities, functional impairment, therapy benefits and risks, pts preferences, and AML features influence this choice. The SIE/SIES/GITMO (“fitness”) criteria (Ferrara, 2013) are a valuable and comprehensive tool, but a revalidation is needed in the light of the new treatment options. Methods: Within the Rete Ematol

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Obersteiner, Andreas, Martha Wagner Alibali, and Vijay Marupudi. "Comparing fraction magnitudes: Adults’ verbal reports reveal strategy flexibility and adaptivity, but also bias." Journal of Numerical Cognition 8, no. 3 (2022): 398–413. http://dx.doi.org/10.5964/jnc.7577.

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Many studies have used fraction magnitude comparison tasks to assess people’s abilities to quickly assess fraction magnitudes. However, since there are multiple ways to compare fractions, it is not clear whether people actually reason about the holistic magnitudes of the fractions in this task and whether they use multiple strategies in a flexible and adaptive way. We asked 72 adults to solve challenging fraction comparisons (e.g., 31/71 vs. 13/23) on a computer. In some of these comparisons, using benchmarks (i.e., reference numbers such as 1/2) was potentially beneficial. After each trial, p

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Ferrari, S., and P. O. Cerutti. "Timber trade in the eastern Democratic Republic of the Congo (DRC): effectiveness of timber parks in tackling tax frauds." International Forestry Review 25, no. 2 (2023): 177–89. http://dx.doi.org/10.1505/146554823837244446.

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The Democratic Republic of the Congo (DRC) shares borders with nine countries and has around 150 million hectares of tropical moist forests. A moratorium on logging titles has been in place since 2002 and infrastructure is very poor. The country plans to lift the moratorium and invest in infrastructure as part of the broader East-African road and railway networks. We present a case-study conducted for thirty months (2020– 2022) on timber trade and export at the first 'timber park' established on the eastern border. Multiple forms of potentially illegal timber trade were detected. In the case o

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Borlenghi, Erika, Chiara Pagani, Claudia Basilico, et al. "Secondary Acute Myeloid Leukemia Is an Heterogeneous Subgroup of Elderly AML Where Patient’s Fitness Criteria and ELN Prognostic Stratification Can be Applied to Guide Treatment Decisions: An Analysis of 127 Patients By the Network Rete Ematologica Lombarda (REL)." Blood 124, no. 21 (2014): 953. http://dx.doi.org/10.1182/blood.v124.21.953.953.

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Abstract Background: According to the WHO classification, secondary acute myeloid leukemia (s-AML) includes cases occurring in patients (pts) receiving prior antineoplastic treatments as well as cases developing in pts with a history of previous hematology disorders, such as a myelodysplastic syndrome (MDS) or a chronic myeloproliferative disease (MPD). Outcomes for this large group of pts, which has a high median age and a high frequency of unfavourable cytogenetics, has been traditionally considered very poor, compared to AML developing “de novo”, and treatment with intensive chemotherapy (i

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Lee, Duk-Hee, Miquel Porta, Lars Lind, P. Monica Lind, and David R. Jacobs. "Neurotoxic chemicals in adipose tissue." Neurology 90, no. 4 (2018): 176–82. http://dx.doi.org/10.1212/wnl.0000000000004851.

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Midlife obesity is associated with increased risk of dementia, whereas late-life obesity is commonly associated with a lower risk of dementia. Although methodologic issues are often discussed in this apparent risk reversal, chronic exposure to low-dose organochlorine pesticides (OCPs), an emerging risk factor for dementia in general populations, may contribute to a direct explanation for these differences. OCPs are strong lipophilic chemicals with very long half-lives (several years), primarily stored in adipose tissue and very slowly released and metabolized over years. As serum concentration

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Allsop, Cheryl, and Sophie Pike. "Investigating homicide: back to the future." Journal of Criminological Research, Policy and Practice 5, no. 3 (2019): 229–39. http://dx.doi.org/10.1108/jcrpp-03-2019-0021.

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Purpose The purpose of this paper is to suggest two things: first, that the scientific and technological developments and increased regulation that have shaped homicide investigations in England and Wales over the last few decades have provided today’s investigators with opportunities not available to their predecessors, and play a key role in solving unsolved homicides. Second, however, the authors suggest that such developments have created new challenges for investigators, challenges that impede current investigations, potentially creating the future unsolved cases. Design/methodology/appro

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Forberg, E., G. Svolba, E. Jimenez-Boj, B. Krinninger, and H. H. Watzke. "A Prospective Controlled Trial Comparing Weekly Self-testing and Self-dosing with the Standard Management of Patients on Stable Oral Anticoagulation." Thrombosis and Haemostasis 83, no. 05 (2000): 661–65. http://dx.doi.org/10.1055/s-0037-1613888.

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SummaryOral anticoagulant therapy requires frequent laboratory controls of its intensity to assure therapeutic efficacy and to prevent potentially life threatening adverse events. It is generally assumed, that increasing the frequency of testing would lead to a better control of anticoagulation. We tested this hypothesis in a prospective controlled trial comparing weekly self-testing and self-dosing (self management) with the standard-management of these patients in an anticoagulation clinic. Only patients with stable anticoagulation were included into the study. We recorded 2733 weekly determ

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Hoes, Charles, Ted Yellman, and Thomas Murray. "Letters to the Editor." Journal of System Safety 57, no. 2 (2022): 4–8. http://dx.doi.org/10.56094/jss.v57i2.188.

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Software Safety vs Software Reliability While looking back through Vol. 56, No. 1 (Summer 2020) of Journal of System Safety, I finally took the time to read Nathaniel Ozarin’s article “Lessons Learned in a Complex Software Safety Program.” The article is quite interesting and thought provoking, comparing what actually occurs while implementing a system safety program to the idealized descriptions found in documents such as MIL-STD-882, JSSSEH and AOP-52. While I found the article interesting and informative, I noted that the author consistently characterizes the “software safety problem”

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Ross, Jeffrey S., Ethan Sokol, Jo-Anne Vergilio, et al. "Primary versus metastatic intrahepatic cholangiocarcinoma: A comparative comprehensive genomic profiling (CGP) study." Journal of Clinical Oncology 38, no. 4_suppl (2020): 578. http://dx.doi.org/10.1200/jco.2020.38.4_suppl.578.

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578 Background: Genomic alterations (GA) characteristic of IHCC are well known. We queried whether the GA of IHCC from primary tumor biopsies (p-bx) would differ from IHCC metastasis biopsies (m-bx). Methods: CGP was performed on 1,268 cases of advanced stage IHCC using p-bx in 1,048 cases and m-bx from 220 cases. Tumor mutational burden (TMB) was determined on 0.8-1.1 Mbp of sequenced DNA and microsatellite instability (MSI) was determined on 114 loci. PD-L1 expression in tumor cells (Dako 22C3) was measured by IHC. Results: M-bx sites included: lymph nodes (63), soft tissues (47), peritoneum

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Yoshifuji, Kota, Kyoko Inamoto, Kazuhiko Kakihana, et al. "Clinical Efficacy of Prebiotics on Transplant-Related Complications." Blood 132, Supplement 1 (2018): 4573. http://dx.doi.org/10.1182/blood-2018-99-114845.

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Abstract Introduction Although allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curable treatment for various hematological malignancies, some serious comorbidities are still problematic, and acute graft-versus-host disease (aGVHD) is a major cause of morbidity and mortality. The gut microbiota and its metabolites have been reported to play pivotal roles in both intestinal inflammation and the immune system. Also in allo-HSCT, it is increasingly evident that imbalance in the gut microbiota (dysbiosis) related to the development of aGVHD. Short chain fatty acids (

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Dhimolea, Eugen, Emily King, Michal Sheffer, et al. "Constitutive Vs. Stroma-Induced Kinase Dependencies in Myeloma Cells: Functional Mapping Using Small Molecule Inhibitors As Chemical Probes." Blood 126, no. 23 (2015): 3709. http://dx.doi.org/10.1182/blood.v126.23.3709.3709.

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Abstract The functional characterization of kinases in multiple myeloma (MM) cells has mainly involved the use of RNAi, a mechanistic approach inherently dissimilar to small molecule inhibitors that are applied in the clinic. Furthermore, in the bone marrow (BM) microenvironment, where MM cells primarily reside, BM stromal cells (BMSCs) and other nonmalignant cell populations can function as "accessory" cells and alter the vulnerability of MM cells to diverse targeted therapies, including kinase inhibitors. In order to characterize how the kinase dependencies of MM cells differ in the presence

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Carter, Patsy, and Tomas C. Welbourne. "Glutamate transport asymmetry in renal glutamine metabolism." American Journal of Physiology-Endocrinology and Metabolism 274, no. 5 (1998): E877—E884. http://dx.doi.org/10.1152/ajpendo.1998.274.5.e877.

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d-Glutamate (Glu) was previously shown to block l-Glu uptake and accelerate glutaminase flux in cultured kidney cells [Welbourne, T. C., and D. Chevalier. Am. J. Physiol. 272 ( Endocrinol. Metab. 35): E367–E370, 1997]. To test whether d-Glu would be taken up by the intact functioning kidney and effect the same response in vivo, male Sprague-Dawley rats were infused withd-Glu (2.6 μmol/min), and renal uptake of d- andl-Glu was determined from chemical and radiolabeled arteriovenous Glu concentration differences times renal plasma flow. The amount removed was then compared with that amount filte

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Roeland, Eric, Joseph Ma, Gary Binder, et al. "Hospitalization costs for nausea and vomiting: A savings opportunity." Journal of Clinical Oncology 35, no. 31_suppl (2017): 155. http://dx.doi.org/10.1200/jco.2017.35.31_suppl.155.

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155 Background: Nausea and vomiting (NV) are tracked by CMS as 2 of 10 top drivers of potentially avoidable hospital admissions for patients with cancer. These admissions pose a savings opportunity, yet limited literature exists on the costs of chemotherapy-induced NV (CINV). Burke’s 2010 assessment of 19,139 patients from 2004-2007 found CINV hospitalizations cost $7,448 and comprised the majority of overall CINV events and costs vs ambulatory events. Rashid (2016) evaluated 1,682 patients with metastatic breast cancer from 2007-2011 and found CINV admissions cost $10,074 in 2013 US dollars.

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Gaponova, Zhanna K., and Elena V. Nikkareva. "Communal apartment (kommunalka) in the reference field of modern fiction for children and adolescents." Tekst. Kniga. Knigoizdanie, no. 35 (2024): 35–53. http://dx.doi.org/10.17223/23062061/35/3.

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Representation in the modern culture of the Soviet past is associated with such a phenomenon as a communal apartment, which is also in demand in modern literature for children and adolescents. In the article, based on the material of the Corpus of Russian Prose for Children and Youth, as well as the most representative examples from the works of the last decade for children and adolescents, an attempt is made to determine the specifics of the topos of a communal apartment, which has become a “system sign” (referent) of Soviet childhood. The vectors of interpretation of a communal apartment set

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Liebers, Nora, Hervé Finel, Dominic Edelmann, et al. "A Propensity Score-Matched Analysis on the Outcomes of Brexucabtagene Autoleucel from Zuma-2 Study and Allogeneic Stem Cell Transplantation from the EBMT Database in Relapsed and Refractory Post-Btki Mantle Cell Lymphoma." Blood 142, Supplement 1 (2023): 3494. http://dx.doi.org/10.1182/blood-2023-174368.

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Introduction Brexucabtagene autoleucel (brexu-cel), an autologous anti-CD19 CAR T-cell therapy, is approved in the US for the treatment of relapsed/refractory (r/r) mantle cell lymphoma (MCL) and in Europe for r/r MCL after ≥2 prior lines of therapies, including Bruton's tyrosine kinase inhibitor (BTKi). The pivotal ZUMA-2 trial demonstrated very good efficacy of brexu-cel in r/r MCL and tolerable safety including cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome (Wang et al. J Clin Oncol. 2022). Allogeneic stem cell transplantation (alloSCT) is potentially c

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Jonsson, Bengt Gunnar, Johan Svensson, Grzegorz Mikusiński, Michael Manton, and Per Angelstam. "European Union’s Last Intact Forest Landscapes are at A Value Chain Crossroad between Multiple Use and Intensified Wood Production." Forests 10, no. 7 (2019): 564. http://dx.doi.org/10.3390/f10070564.

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Research Highlights: The European Union’s last large intact forest landscapes along the Scandinavian Mountain range in Sweden offer unique opportunities for conservation of biodiversity, ecological integrity and resilience. However, these forests are at a crossroad between intensified wood production aimed at bio-economy, and rural development based on multi-functional forest landscapes for future-oriented forest value chains. Background and Objectives: We (1) estimate the area of near-natural forests potentially remaining for forest harvesting and wood production, or as green infrastructure f

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Cozza, E., A. Bellin, L. Videsott, A. Cutolo, and S. Temistoclakis. "P22 AN UNEXPECTED DIAGNOSIS; GEMELLA MORBILLORUM, A POORLY KNOWN KILLER." European Heart Journal Supplements 25, Supplement_D (2023): D47. http://dx.doi.org/10.1093/eurheartjsupp/suad111.109.

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Abstract 58–year–old woman, previous smoking habit. In medical history holosystolic murmur since childhood. At echocardiogram performed in 2019: "VS with preserved FE, mild–to–moderate IA, likely perimembranous DIV." No major comorbidities. In June 2021, she was admitted to the Mestre NICU for paroxysmal complete atrioventricular block. On echocardiogram, mild worsening of IA was described, with a sub–valvular shunt and doubtful aortic bicuspidia. At 24 hours after admission, the patient underwent definitive bicameral PM implantation. In light of the clinical and echocardiographic suspicious,

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D'Avolio, Antonio, Silvia De Francia, Alessandra Ariaudo, et al. "Single-Nucleotide Polymorphisms of ABCB1 Gene Influence Intracellular Concentrations of Dasatinib." Blood 120, no. 21 (2012): 4903. http://dx.doi.org/10.1182/blood.v120.21.4903.4903.

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Abstract Abstract 4903 Background Use of BCR-ABL TKIs (Tyrosine-Kinase inhibitors) is the standard therapy for chronic myeloid leukemia. Dasatinib at the dosage of 100 mg once daily (QD) has been registered as first-line treatment for chronic phase chronic myeloid leukemia (CML) because it has been shown to be able to elicit faster and deeper cytogenetic and molecular responses than imatinib 400 QD, preventing also some events of progression to advanced phases of the disease, that can still occur during the first 2–3 years of treatment with TKIs. This is likely to be related to the strength of

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Longobardi, Giuseppe. "Theory and experiment in Parametric Minimalism: the case of Romance Negation." Revista Linguíʃtica 13, no. 2 (2017): 108. http://dx.doi.org/10.31513/linguistica.2017.v13n2a13506.

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<p>This paper has a double goal: frst, it lays down and refnes the basic hypotheses on the parametric structure of Romance negative systems that were originally introduced in my presentation at the Venice GLOW Workshop on Dialect Variation in 1987 (especially sections 3-9 and 11-13)3; then it further elaborates on them (sections 10 and 14-15), and revisits the conclusions (sections 16-22) in light of a more recent minimalist approach to the possible formats of parametric variation (the Principles &amp; Schemata model, sketched in Longobardi 2005a). More generally, the theoretical foc

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Kaspers, Gertjan J., M. Zimmermann, G. Fleischhack, et al. "Relapsed Acute Myeloid Leukemia in Children and Adolescents: Interim Results of the International Randomised Phase III Study “Relapsed AML 2001/01”." Blood 106, no. 11 (2005): 897. http://dx.doi.org/10.1182/blood.v106.11.897.897.

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Abstract Relapse occurs in 30–40% of newly diagnosed AML patients, with long-term survival in 20% of them. We initiated a study for relapsed AML excluding AML M3 and those &gt;18 years of age. As backbone, FLAG is being used for 2 consecutive courses: fludarabine 30 mg/m2/day x 5, cytarabine 2 g/m2/day x 5, G-CSF 200 μg/m2/dose for 6 days, starting day −1. Liposomal daunorubicin (DaunoXome®, DNX) is a “new” anthracycline with potentially less cardiotoxicity, applicable in the total group of patients, and with the perspective to be useful at initial treatment as well. Therefore, DNX at 60 m

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Kaspers, Gertjan J., M. Zimmermann, G. Fleischhack, et al. "Relapsed Acute Myeloid Leukemia in Children and Adolescents: Interim Report of the International Randomised Phase III Study Relapsed AML 2001/01." Blood 108, no. 11 (2006): 2013. http://dx.doi.org/10.1182/blood.v108.11.2013.2013.

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Abstract Relapse occurs in 30–40% of newly diagnosed AML patients, with long-term survival in 20%. Aiming at improved outcome, we initiated a prospective, randomised study for relapsed AML, excluding AML M3 and those >18 years of age at initial diagnosis. FLAG is being used for 2 consecutive courses: fludarabine 30 mg/m2/day x 5, cytarabine 2 g/m2/day x 5, G-CSF 200 μg/m2/dose for 6 days, starting day -1. Liposomal daunorubicin (DaunoXome, DNX) is a new anthracycline with potentially less cardiotoxicity. Therefore, DNX at 60 mg/m2/day on days 1, 3 and 5 was randomly added or not to the firs

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Primo, Daniel, Joan Ballesteros, Antonio Jimenez, et al. "Novel Ex Vivo Assay Measures Drug-Induced Depletion of Hematopoietic Progenitors As an Estimate of Hematotoxicity." Blood 124, no. 21 (2014): 5785. http://dx.doi.org/10.1182/blood.v124.21.5785.5785.

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Abstract Background and Objectives: Recently, knowledge of the specific genetic markers responsible for cancer malignancies and their associated signaling pathways have generated many new targets that promise to increase drug efficacy while reducing side effects such as hematotoxicity. Although hematotoxicity is widely assumed to be the result of depleting hematopoietic progenitors, in particular myeloid progenitors, there are no assays to test new compounds in bone marrow samples to investigate this effect. Because these effects are patient-specific, an assay that identifies those patients ri

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Ajiboye, Onaopemipo B., Sophie Lanzkron, Mary Catherine Beach, Shawn M. Bediako, Arthur L. Burnett, and Carlton Haywood. "Trends In the Hospital Treatment of Sickle Cell Disease-Related Priapism In the United States: 1998 to 2007,." Blood 118, no. 21 (2011): 4195. http://dx.doi.org/10.1182/blood.v118.21.4195.4195.

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Abstract Abstract 4195 OBJECTIVE: Priapism is a serious complication of sickle cell disease (SCD). Urologic guidelines recommend that the management of priapism should entail intracavernous treatment in addition to treatment for the underlying condition. One meta-analysis suggests that transfusion is an ineffective and potentially harmful therapy for priapism in SCD. Nevertheless, little is known about how priapism is actually managed for these patients. We examined in-hospital treatment trends of priapism among male SCD patients in the United States (US) over a 10-year period with a focus on

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Maroney, Thomas T., Yusen He, Srujankumar Dhannapuneni, Nikita C. Shah, Amy Iarrobino Laughlin, and Tomas Dvorak. "Independent validation of 30-day emergency department visit after initial chemotherapy A-PROACCT model." Journal of Clinical Oncology 42, no. 16_suppl (2024): e23243-e23243. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e23243.

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e23243 Background: This study assessed model performance and, more importantly, the clinical usefulness of the PROACCT model created by Grant et al. (JAMA, 2019), refined as A-PROACCT by Stein et al. (JOP, 2023) with data from Orlando Health. The predictive performance of models anticipating acute care events within thirty days (ACE30) of initial chemotherapy administration (ICA) were evaluated. Methods: Stein et al. models classified high-risk patients as those whose model output risk score was at or above the 90th percentile. They studied 5153 ICAs between July and November of 2021, of which

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АВДЕЕВ, А. В., and А. Е. ГУЛЯЕВ. "CLINICAL AND ECONOMIC EVALUATION OF THE EFFECTIVENESS OF THE CEREBROLYSIN USING IN NEUROLOGICAL PATIENTS WITH POST-STROKE COMPLICATIONS IN PUBLIC HEALTH CONDITIONS OF THE REPUBLIC OF KAZAKHSTAN." Farmaciâ Kazahstana, no. 3 (July 20, 2022): 137–48. http://dx.doi.org/10.53511/pharmkaz.2022.44.53.021.

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Постинсультная реабилитация в Казахстане является комплексом регламентированных процедур, направленных на сохранение, частичное или полное восстановление нарушенных и (или) утраченных функций организма пациента. Однако, один из главных факторов реабилитации постинсультных пациентов - медикаментозная реабилитация, не конкретизирована и фактически не разработана, несмотря на то, что неврологические нарушения являются частым и потенциально инвалидизирующим последствием инсульта. Цель исследования. Проведение оценки клинико-экономической эффективности применения препарата Церебролизин у неврологич

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Eisfeld, Ann-Kathrin, Jessica Kohlschmidt, Krzysztof Mrózek, et al. "The 2017 European Leukemianet Genetic Risk Classification Performs Poorly in Older Patients with Acute Myeloid Leukemia (AML) and Should be Refined to Identify Patients Requiring Additional or Alternative Treatment." Blood 134, Supplement_1 (2019): 2681. http://dx.doi.org/10.1182/blood-2019-130076.

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AML is a disease of the elderly. Patients aged ≥60 years (y) account for ~65% of all AML patients. However, while 40% of younger AML patients achieve long term survival, only 5-15% of older patients do. Especially given increasing availability of alternative treatment strategies the identification of patients who benefit from standard induction chemotherapy and those who do not is of crucial importance. The 2017 European LeukemiaNet Genetic Risk Classification (ELN GRC) provides guidance on genetic risk stratification of AML patients and is currently routinely used in clinical practice for bot

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Russell, Nigel H., Andrew J. Howman, Keith Wheatley, et al. "Outcome of Reduced Intensity Allografts in Patients Aged Over 45 Years with Acute Myeloid Leukaemia: Initial Results of the MRC AML15 Trial." Blood 114, no. 22 (2009): 523. http://dx.doi.org/10.1182/blood.v114.22.523.523.

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Abstract Abstract 523 Introduction: The advent of reduced intensity conditioning (RIC) regimens permits the delivery of allogeneic stem cell transplant (alloSCT) with a potentially curative graft-versus-leukaemia effect in patients with acute myeloid leukaemia (AML) whose outcome with conventional chemotherapy or conventional myeloablative SCT would be poor. Although widely utilised in the management of older patients with AML in 1st complete remission (CR) there are no randomised trials or “donor v. no donor” analyses supporting a role for RIC alloSCT in this setting. Methods: We have examine

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Zacharia, George, Bartosz A. Walczyszyn, Diana Lee, Guillame Stoffels, Colette Spaccavento, and Randy L. Levine. "Characteristics of the Post-Surgical Decrease in Platelet Counts in Orthopedic Patients." Blood 128, no. 22 (2016): 2554. http://dx.doi.org/10.1182/blood.v128.22.2554.2554.

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Abstract Background: The characteristics of post-surgical thrombocytopenia have not been well described. Interpretation of the reported data was potentially confounded by the fact that many of the patients were receiving heparin.1,2 We aimed to evaluate the post-operative thrombocytopenia in orthopedic surgery patients who were not exposed to heparin in order to better define the characteristics of this phenomenon. Methods: A retrospective chart review was conducted on patients who underwent a knee or hip replacement from 2012 to 2015. Exclusion criteria were: age <18, pre-op platelet count

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Goel, Swati, Laura K. Fogli, Mark Sundrud, Stefano Casola, Klaus Rajewsky, and Sergei B. Koralov. "Role of STAT3 and Th17 Cells in Cutaneous T Cell Lymphoma." Blood 120, no. 21 (2012): 66. http://dx.doi.org/10.1182/blood.v120.21.66.66.

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Abstract Abstract 66 Background Cutaneous T cell Lymphoma (CTCL) is a heterogeneous group of non-Hodgkin's lymphomas characterized by skin-homing malignant T cells. The etiology of CTCL remains enigmatic, but constitutive Signal Transducer and Activator of Transcription 3 (STAT3) activity is characteristic of this malignancy. CTCL cell lines undergo growth arrest and apoptosis following inhibition of STAT3 signaling, suggesting that STAT3 may be a pro-survival factor in these cells. STAT3 phosphorylation is also required for the initiation and maintenance of the Th17 differentiation program, a

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Tilch, Marie-Kristin, Christian Schmidt, Marek Trneny, et al. "Trials in Progress: Carman - an International, Randomized Phase II Study Evaluating Early Treatment Intensification in Patients with High Risk Mantle Cell Lymphoma Using CAR-T-Cell Treatment after an Abbreviated Induction Therapy with Rituximab and Ibrutinib and 6 Months Ibrutinib Maintenance (Arm A) As Compared to Standard of Care Induction and Maintenance (Arm B)." Blood 144, Supplement 1 (2024): 4422.3. https://doi.org/10.1182/blood-2024-206931.

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Mantle cell lymphoma (MCL) is a rare lymphoma subtype that accounts for 8% of Non-Hodgkin lymphomas and is still considered incurable. Prognostic parameters such as TP53 alterations, high Ki-67 proliferation index, blastoid or pleomorphic morphologic characteristics and/or high-risk combined MCL International Prognostic Index (MIPI-c) are associated with poor outcome. Chemoimmunotherapy and targeted therapies such as Bruton's tyrosine kinase inhibitors (BTKi) may induce remission in such high-risk patients, but early relapses frequently occur and actually there is a unmet need for improved tre

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Tawara, Isao, Kana Okamori, Naoyuki Katayama, Hiroshi Shiku, and Hiroaki Ikeda. "Tumor-Specific Donor Lymphocyte Infusion for Tumor Relapse after MHC-Haploidentical Hematopoietic Stem Cell Transplantation." Blood 128, no. 22 (2016): 2157. http://dx.doi.org/10.1182/blood.v128.22.2157.2157.

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Abstract Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative therapy for refractory hematologic malignancies such as leukemia and myelodysplastic syndrome. Tumor relapse, graft-vs host disease (GVHD) and infections are, however, major obstacles to successful allo-HSCT. Donor lymphocyte infusion (DLI) is carried out in some cases of tumor relapse and infections after allo-HSCT. DLI potentially induces or aggravates GVHD due to allo-reactivity of the lymphocytes used for infusion and the efficacy of DLI for tumor relapse is actually limited. Therefore, development of the

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Genuardi, Elisa, Beatrice Alessandria, Irene Della Starza, et al. "MRD Monitoring By Euroclonality IGH Based NGS Approach Predicts Outcome in Follicular Lymphoma Patients Lacking a Conventional BCL2::IGH Marker: A Substudy from the Fondazione Italiana Linfomi (FIL) FOLL12 Trial." Blood 142, Supplement 1 (2023): 4373. http://dx.doi.org/10.1182/blood-2023-181813.

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Background. Despite durable clinical responses achieved by chemo-immunotherapy in follicular lymphoma (FL) patients, most of them eventually relapse. Actually, minimal residual disease (MRD) analysis based on the detection of BCL2::IGH rearrangement by PCR is the most widely used and standardized approach, able to early identify patients at high risk of disease reappearance. Nevertheless, this tool fails the molecular marker definition in up to 45% of cases, hampering the disease monitoring in a large group of patients. In the last decade, the continuous improvement of next-generation sequenci

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Krzysztof Krajewski. "Illegal Drugs and Penal Law (Some Problems of the Theory of Criminalization)." Archives of Criminology, no. XXI (July 22, 1995): 41–79. http://dx.doi.org/10.7420/ak1995b.

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The present policy of all countries of the world towards narcotic and psychotropic drugs is in fact prohibitionIST. This means that all circulation of such drugs ‒ their manufacture, transport, import, export, introduction into trade, giving, and sometimes also possession – is illegal and carries most severe penal sanctions in some cases. It should be borne in mind, though, that this prohibition is ONLY about eighty years old now. Before, despite a large numer of addicts (not at all smaller than today according to some estimations), purely medical approach to such persons prevailed, and the dr

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Emmerson, Parker Yehushuason, and J. Buchanan Buchanan Ryan. "Potentiation vs. Permission: Formalizing Implicit Associations in Mathematical Structures." May 6, 2025. https://doi.org/10.5281/zenodo.15347483.

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This paper investigates the formalization of implicit associations within mathematical structures through the contrasting lenses of <em>potentiation</em> and <em>permission</em>. While implicit associations—underlying, often non-definitional relationships between structural elements—play a critical role in shaping mathematical behavior, their abstract nature has hindered systematic analysis. We propose a dual framework where <em>potentiation</em> characterizes the inherent capacity of elements to enable or amplify specific properties or operations, while&nb

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Havranek, Michael M., Yuliya Dahlem, Selina Bilger, et al. "Validity of different algorithmic methods to identify hospital readmissions from routinely coded medical data." Journal of Hospital Medicine, July 25, 2024. http://dx.doi.org/10.1002/jhm.13468.

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AbstractBackgroundHospital readmission rates are used for quality and pay‐for‐performance initiatives. To identify readmissions from administrative data, two commonly employed methods are focusing either on unplanned readmissions (used by the Centers for Medicare & Medicaid Services, CMS) or potentially avoidable readmissions (used by commercial vendors such as SQLape or 3 M). However, it is not known which of these methods has higher criterion validity and can more accurately identify actually avoidable readmissions.ObjectivesA manual record review based on data from seven hospitals was u

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