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Thèses sur le sujet « PPIasa »

Auteur : Grafiati

Publié le 4 juin 2021

Mis à jour le 1 février 2022

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1

Suñé, Rodríguez Guillermo. "Identificación de proteínas que interaccionan con CypA, CypB y FKBP12 y su implicación en la toxicidad renal producida por los inmunosupresores CsA y FK506." Doctoral thesis, Universitat de Barcelona, 2008. http://hdl.handle.net/10803/1017.

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La Ciclosporina A (CsA) es un fármaco inmunosupresor que ha supuesto una revolución en el trasplante de órganos. A pesar de sus propiedades anti-inflamatorias, su uso se ha visto limitado por los efectos tóxicos que causa en algunos pacientes. La CsA inhibe la trascripción de genes involucrados en el sistema inmune. Se cree que esta inhibición es la causante de los efectos tóxicos producidos por el fármaco. El modo de acción de CsA está mediado por la unión de sus principales receptores intracelulares, las ciclofilinas (Cyps). <br/><br/>Las ciclofilinas son proteínas que están conservadas en t

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Georgiou, Charis. "Rational design of isoform specific ligands." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28713.

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Cyclophilins (Cyp) are proteins that catalyze the interconversion of trans/cis isomers of proline belonging to the peptidyl-prolyl isomerases family (PPIase). In addition to their PPIase activity, Cyps have diverse biological roles and have been implicated in a number of different diseases such as HIV-1 and HCV. Although several Cyp inhibitors have been reported in the literature, none are able to inhibit with high specificity various Cyp isoforms. To facilitate the development of isoform-specific Cyp ligands, we have pursued detailed studies of Cyp dynamics and ligand binding thermodynamics u

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Norville, Isobel Harriet. "The identification and characterisation of PPIases from Burkholderia pseudomallei and Burkholderia thailandensis." Thesis, University of Exeter, 2011. http://hdl.handle.net/10036/3152.

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The aim of this study was to identify and characterise peptidyl-prolyl cis-trans isomerases (PPIases) from the bacterium Burkholderia pseudomallei, the causative agent of the disease melioidosis. The longer term goal was to assess their potential as vaccine candidates or antimicrobial targets. Using bioinformatic approaches, six putative FK506-binding proteins (FKBPs) proteins and three putative parvulin proteins were identified in B. pseudomallei. Of these, six were expressed and purified as recombinant proteins. The purified proteins were used to immunise BALB/c mice, with some providing pro

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Albasri, Hibah Mohammed. "Cell binding factor of Neisseria meningitidis is a PPIase with chaperone activity involved in outer membrane protein biogenesis." Thesis, University of Nottingham, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.727113.

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Neisseria meningitidis is a major cause of meningitis and septicaemia which remain an important concern worldwide. Despite the advances in understanding the pathogenicity of N. meningitidis; its complexity is still not fully elucidated. Noteworthy, while a large number of complete genome sequences are now available, the annotation of each of the genes is incomplete with information either lacking entirely or based only on homology with genes in other species. In searching for novel genes in N. meningitidis strain MC58 that might be involved in the pathogenicity, a putative operon encoded by th

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Keogh, Rebecca. "Investigation of Peptidyl-prolyl cis/trans isomerases in the virulence of Staphylococcus aureus." Ohio University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou158764341402963.

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6

Xu, Guoyan. "Pin1 Inhibitors: Towards Understanding the Enzymatic Mechanism." Diss., Virginia Tech, 2010. http://hdl.handle.net/10919/37823.

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An important role of Pin1 is to catalyze the cis-trans isomerization of pSer/Thr-Pro bonds; as such, it plays an important role in many cellular events through the effects of conformational change on the function of its biological substrates, including Cdc25, c-Jun, and p53. The expression of Pin1 correlates with cyclin D1 levels, which contributes to cancer cell transformation. Overexpression of Pin1 promotes tumor growth, while its inhibition causes tumor cell apoptosis. Because Pin1 is overexpressed in many human cancer tissues, including breast, prostate, and lung cancer tissues, it plays

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Mercedes-Camacho, Ana Yokayra. "Pin1: WW domain ligands, catalytic inhibitors, and the mechanism." Diss., Virginia Tech, 2011. http://hdl.handle.net/10919/77093.

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The peptidyl prolyl cis/trans isomerase, PPIase, has been the focus of numerous studies in the field of cell cycle regulation since proline-directed phosphorylation is an essential signaling mechanism that might arrest cancer proliferation. Pin1 is the first phosphorylation-dependent PPIase enzyme to be discovered. The Pin1 regulatory mechanism, acting on other mitotic proteins in vivo and in vitro, remains largely unknown. For the study of Pin1 function, two types of assays were used to identity ligands for Pin1: (1) The Enzyme-Linked Enzyme Binding Assay (ELEBA) for the identification of WW

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Brasseur, Anaïs. "Etude de composantes de la voie TOR: caractérisation de TbFKBP12, une protéine de la famille des PPIases (isomérases) impliquée dans l'homéostasie du flagelle chez Trypanosoma brucei." Doctoral thesis, Universite Libre de Bruxelles, 2009. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210240.

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Trypanosoma brucei est un parasite africain unicellulaire, responsable chez l’homme de la maladie du sommeil et chez les bovins de la Nagana. Il passe par différents stades lors de son cycle de vie, les deux principaux étant la forme sanguicole qui prolifère dans le sang des mammifères infectés, et la forme procyclique qui colonise le tube digestif du vecteur, la mouche glossine. <p>Les trypanosomes sont extracellulaires, ils possèdent un flagelle qui leur permet de se mouvoir dans les différents milieux qu’ils infestent. La structure de celui-ci contient des éléments conservés au cours de l’é

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Rivas, Santos Pep. "Design and synthesis of engineered peptides to target undruggable PPIs: from in silico to in vitro studies." Doctoral thesis, Universitat de Barcelona, 2019. http://hdl.handle.net/10803/668150.

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Major unsolved diseases such as Cancer, cardiopathies or neurodegenerative disorders are frequently related with the malunction of complex protein networks. These networks are integrated by the interaction of multiple proteins that in case of a misregulation can trigger an undesired effect. Therefore, disruption of protein-protein interactions (PPIs), that are involucrated in a protein signalling cascade which is relevant for a particular diseases, is a hot topic in pharmaceutical industry. Unfortunately, traditional small molecules have been found to not be the most suitable inhibitiors of th

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Ruiz-Gómez, Gloria, John C. Hawkins, Jenny Philipp, et al. "Rational Structure-Based Rescaffolding Approach to De Novo Design of Interleukin 10 (IL-10) Receptor-1 Mimetics." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-215877.

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Tackling protein interfaces with small molecules capable of modulating protein-protein interactions remains a challenge in structure-based ligand design. Particularly arduous are cases in which the epitopes involved in molecular recognition have a non-structured and discontinuous nature. Here, the basic strategy of translating continuous binding epitopes into mimetic scaffolds cannot be applied, and other innovative approaches are therefore required. We present a structure-based rational approach involving the use of a regular expression syntax inspired in the well established PROSITE to defin

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11

Berg, Christian. "The ever increasing use of acid suppressive therapy : Descriptive analysis of data from the national wholesale and prescription databases on the consumption of proton pump inhibitor in Norway." Thesis, Nordic School of Public Health NHV, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:norden:org:diva-3223.

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Pharmacoepidemiological analyses are needed as a background for evaluation of drug use and for making cost-effective priorities. Drug sales and prescription databases provide useful tools for analysis of drug consumption and expenditures. In this essay, an analysis of the sales and prescribing of proton pump inhibitors (PPIs), drugs used for acid related gastric disorders, are presented. Since 1996, the consumption of PPIs in Norway has increased by approximately 10 % per year, with esomeprazole as the most commonly used drug. An increasing number of individuals are using these drugs with cons

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Ruiz-Gómez, Gloria, John C. Hawkins, Jenny Philipp, et al. "Rational Structure-Based Rescaffolding Approach to De Novo Design of Interleukin 10 (IL-10) Receptor-1 Mimetics." Public Library of Science, 2016. https://tud.qucosa.de/id/qucosa%3A30052.

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Tackling protein interfaces with small molecules capable of modulating protein-protein interactions remains a challenge in structure-based ligand design. Particularly arduous are cases in which the epitopes involved in molecular recognition have a non-structured and discontinuous nature. Here, the basic strategy of translating continuous binding epitopes into mimetic scaffolds cannot be applied, and other innovative approaches are therefore required. We present a structure-based rational approach involving the use of a regular expression syntax inspired in the well established PROSITE to defin

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13

Worseck, Josephine Maria. "Characterization of phosphorylation-dependent interactions involving neurofibromin 2 (NF2, merlin) isoforms and the Parkinson protein 7 (PARK7, DJ1)." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2012. http://dx.doi.org/10.18452/16533.

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Veränderungen in phosphorylierungsabhängigen Signalwegen, Akkumulation von Proteinaggregaten im Gehirn und neuronaler Zelltod sind Neurodegenerationskennzeichen und Indikatoren für überlappende molekulare Mechanismen. Um Einblicke in die involvierten Signalwege zu erhalten, wurde mit Hilfe eines modifizierten Hefe-Zwei-Hybrid (Y2H)-Systems für 71 Proteine, die mit neurologischen Erkrankungen assoziiert sind, proteomweit nach Protein-Protein Interaktionen (PPIs) gesucht. Für 21 dieser Proteine wurden PPIs identifiziert. Das Gesamtnetzwerk besteht aus 79 Proteinen und 90 PPIs von denen 5 phospho

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14

Carvalho, Mafalda Marques Cirne Machado. "Úlcera péptica: etiopatogenia, diagnóstico, aspetos clínicos e tratamento." Master's thesis, [s.n.], 2013. http://hdl.handle.net/10284/4175.

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Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas<br>A úlcera péptica é uma doença do trato gastrointestinal caracterizada por lesão da mucosa na presença de ácido e pepsina, como consequência de uma ação corrosiva da hipersecreção de ácido gástrico no tecido, causada por um desequilíbrio entre o sistema protetor da mucosa e fatores agressores. A infeção pela bactéria Helicobacter pylori e os anti-inflamatórios não esteroides são considerados os principais fatores de risco no desen

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15

Janse, van Rensburg Hendrika Nicolien. "A longitudinal study of the usage of acid reducing medicine using a medicine claims database / Hendrika Nicolien Janse van Rensburg." Thesis, North-West University, 2007. http://hdl.handle.net/10394/1903.

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Acid-related disorders are common, chronic conditions that have considerable impact on a patient's quality of life. In a study conducted by Majumdar et al. (2003:2411) the prevalence of chronic acid-related disorders was 2.3%. Acid-related disorders represent a major financial consideration with respect to the costs of drug prescribing (Whitaker, 1998:6). Health care cost increases each year. This leads to an increased interest in economic evaluation of health care and medical technologies (Anell & Svarvar, 2000:175). Health care providers no longer make treatment decisions independent of the

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Ping-ChuanWang and 王彬權. "System Calibration of a Portable Panoramic Image Mapping System (PPIMS)." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/84590485068127570899.

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碩士<br>國立成功大學<br>測量及空間資訊學系碩博士班<br>100<br>The development of Mobile Mapping System (MMS) is important for rapid acquisition of 3D spatial information. Nowadays, the Vehicle MMS (VMMS) is one of the system that had well developed and commercialized. This paper proposes a Portable Panoramic Image Mapping System (PPIMS), which is based on MMS. The motivation of this research is concerned about that VMMS will possibility face some problems. Including the stability of electric supply, the difficult preprocess of the system, the precision of image sensors and navigation system, and the limit to get in

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"Type II secretion and secreted ppiases promote low temperature growth and survival in Legionella pneumophila." NORTHWESTERN UNIVERSITY, 2008. http://pqdtopen.proquest.com/#viewpdf?dispub=3303607.

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Po-ChinTsai and 蔡博慶. "Bundle Adjustment and Applications of a Portable Panoramic Image Mapping System (PPIMS)." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/78726245529123166648.

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碩士<br>國立成功大學<br>測量及空間資訊學系碩博士班<br>100<br>This study proposes a Portable Panoramic Image Mapping System (PPIMS), which is based on the principle of the Mobile Mapping System (MMS). The motivation of this design is to develop a portable MMS for rapid acquisition of 3D spatial information. The PPIMS is designed for some difficult accessing areas by vehicles, such as a heavily damaged mountain village or a disaster landscape. This system can improve the mobility and convenience of the Land Vehicle MMS, and aim at the three-dimensional model for disaster areas. PPIMS is equipped with 6 circular a

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19

Brosi, Helen Beate [Verfasser]. "Characterization of preproinsulin (ppins)-specific CD8 T-cell responses in novel models of autoimmune diabetes / vorgelegt von Helen Beate Brosi." 2010. http://d-nb.info/1004738994/34.

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Petty, Duncan R., J. Allan, R. Dawson, and Jonathan Silcock. "How effective are primary care pharmacists at running dyspepsia clinics for patients prescribed PPIs?" 2018. http://hdl.handle.net/10454/16681.

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Yes<br>Introduction As a consequence of the low cost and perceived safety, proton pump inhibitors (PPIs) are widely prescribed but they can cause longterm adverse effects and are often overprescribed. For most patients PPIs should not be continued long-term as patients can become dependent on PPIs and they are rarely stepped down/off treatment. We aimed to measure whether a dyspepsia review service could help patients on PPIs to step down/off treatment whilst still keeping them symptom free. Methods Pharmacists were provided with training on dyspepsia management. Four general practices were

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Chen, Kuan-Chen, and 陳冠臻. "Estimation of Readmission Factors for ACS Patients Who Received Clopidogrel with Clopidogrel PPIs by Data Mining Techniques." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/rup9bt.

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碩士<br>國立中正大學<br>醫療資訊管理研究所<br>103<br>Acute coronary syndrome (ACS) refers to any clinical manifestations of myocardial ischemia, which often caused by coronary thrombosis. For secondary prevention, clinic physicians use antiplatelet agents, such as clopidogrel, to decrease platelet aggregation therefore inhibit thrombus formation. While these drugs are effective in reducing the risk of ACS, they can increase the change of GI bleeding. Proton pump inhibitors (PPIs) are widely used to decrease the opportunity of this side effect. However multiple researches have reported use clopidogrel combinati

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Segoati, Norah Sheillah. "Public Private Institutional Partnerships (PPIPs) in South Africa : the case of service delivery in the health and social development sectors in the Sedibeng District Municipality." Diss., 2015. http://hdl.handle.net/2263/50777.

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This study is premised on a new approach in the study of Public Private Partnerships by introducing a new variable, termed the Institution. The study examines and explores the contributions of public private institutional partnerships in health and social development service delivery at the Sedibeng District Municipality (SDM) of South Africa. The involvement of BHP Billiton and Hollard as entities from the Private Sector, and that of the University of North West in South Africa, has proven to be an important catalyst in the unravelling of systemic quagmires towards the improvement of service

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Velazquez, Hector. "Molecular Dynamics Simulations Towards The Understanding of the Cis-Trans Isomerization of Proline As A Conformational Switch For The Regulation of Biological Processes." 2014. http://scholarworks.gsu.edu/chemistry_diss/89.

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Pin1 is an enzyme central to cell signaling pathways because it catalyzes the cis–trans isomerization of the peptide ω-bond in phosphorylated serine/threonine-proline motifs in many proteins. This regulatory function makes Pin1 a drug target in the treatment of various diseases. The effects of phosphorylation on Pin1 substrates and the basis for Pin1 recognition are not well understood. The conformational consequences of phosphorylation on Pin1 substrate analogues and the mechanism of recognition by the catalytic domain of Pin1 were determined using molecular dynamics simulations. Phosphorylat

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Huang, Yung-Chieh, and 黃勇傑. "Effect of Proton Pump Inhibitors (PPIs) with Health Education Intervention on Gastroesophageal Reflux Disease (GERD) and the Disease Impact Scale." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/73628591879568442281.

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碩士<br>國防醫學院<br>公共衛生學研究所<br>99<br>Background: Gastroesophageal Reflux Disease (GERD) has become a public issue in Taiwan. The incidence and prevalence rate of GERD growing up with aging, westernized diet, lifestyle changes and obesity. However, current clinical diagnosis and treatment only focus on surgery or drugs to inhibit gastric acid secretion, seldom takes into consideration the effect of health education adjuvant treatment, which includes diet, lifestyle modification and disease knowledge, attitude and practice (KAP). Objectives: The aim of this study was to evaluate the effect of healt

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Simard, Anne-Marie. "Stabilité de l’acide ribonucléique pour la datation des fluides corporels en biologie judiciaire." Thèse, 2011. http://hdl.handle.net/1866/5887.

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Des recherches en sciences judiciaires ont montré récemment une possible corrélation entre le temps d’entreposage d’échantillons de fluides corporels et la dégradation de l’ARN dans ceux-ci. Le moment où une tache a été déposée sur une scène de crime peut être important pour déterminer la pertinence d’un échantillon dans une enquête. Dans ce mémoire, nous rapportons les profils de dégradation de quatre ARN différents mesurés par RT-qPCR, soit l’ARN ribosomique 18S et les ARNm de la β-actine, de la glyceraldehyde-3-phosphate déhydrogénase et de la cyclophiline A, obtenus de taches de sang, de

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Pinto, Azevedo-Vethacke Marina Da Conceição [Verfasser]. "The effect of proton pump inhibitors (PPIs) on the orientation of Helicobacter pylori in the gastric mucus of the Mongolian gerbil in vivo / submitted by Marina Da Conceição Pinto Azevedo-Vethacke." 2008. http://d-nb.info/991083601/34.

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Van, Rensburg Hendrika Nicolien Janse. "A longitudinal study of the usage of acid reducing medicine using a medicine claims database / H.N. Janse van Rensburg." Thesis, 2007. http://hdl.handle.net/10394/1903.

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