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Littérature scientifique sur le sujet « Prb6 »

Auteur : Grafiati

Publié le 8 novembre 2023

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Articles de revues sur le sujet "Prb6"

Anisimov, M. A., A. V. Bogach, V. V. Glushkov, S. V. Demishev, N. A. Samarin, N. Y. Shitsevalova, A. V. Levchenko, V. B. Filipov, A. V. Kuznetsov et N. E. Sluchanko. « Suppression of Spin-Glass State in PrB₆ ». Solid State Phenomena 190 (juin 2012) : 221–24. http://dx.doi.org/10.4028/www.scientific.net/ssp.190.221.

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The comprehensive study of transverse magnetoresistance (MR) and magnetization has been carried out on the high quality single crystals of PrB6 in the wide range of temperatures 2-40K and magnetic fields up to 80kOe. In order to estimate the role of boron vacancies in the formation of the new spin-glass (SG) phase detected by Alekseev et al. below 20K the experiments were carried out on the ordinary (initial state) and annealed single crystals of PrB6. The data obtained demonstrate the appearance of spontaneous magnetization below TSG21.3K with M~1.6 emu/mol for initial state and the absence of spontaneous magnetization for the annealed PrB6 samples. On the contrary, quite similar behavior of MR was detected for various samples of PrB6. Our results suggest the existence of the aggregated boron vacancies which provoke the new SG phase formation in PrB6 at TSG.

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Lyons, K. M., J. H. Stein et O. Smithies. « Length polymorphisms in human proline-rich protein genes generated by intragenic unequal crossing over. » Genetics 120, n^o 1 (1 septembre 1988) : 267–78. http://dx.doi.org/10.1093/genetics/120.1.267.

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Abstract Southern blot hybridization analysis of genomic DNAs from 44 unrelated individuals revealed extensive insertion/deletion polymorphisms within the BstNI-type loci (PRB1, PRB2, PRB3 and PRB4) of the human proline-rich protein (PRP) multigene family. Ten length variants were cloned, including alleles at each of the four PRB loci, and in every case the region of length difference was localized to the tandemly repetitious third exon. DNA sequences covering the region of length variation were determined for seven of the alleles. The data indicate (1) that the PRB loci can be divided into two subtypes, PRB1 plus PRB2, and PRB3 plus PRB4, and (2) that the length differences result from different numbers of tandem repeats in the third exons. Variant chromosomes were also identified with different numbers of PRP loci resulting from homologous but unequal exchange between the PRB1 and PRB2 loci. The overall data are compatible with the observed length variants having been generated via homologous but unequal intragenic exchange. The results also indicate that these crossover events are sensitive to the amount of homology shared between the interacting DNA strands. Allelic length variants have arisen independently at least 20 times at the PRB loci, but only one has been detected at a PRH locus. Comparison of the detailed structures of the repetitious regions in PRB and PRH loci shows that the repeats in PRB genes are very similar to each other in sequence and in length. The PRH genes contain fewer repeats, which differ considerably in their individual lengths. These differences suggest that the larger number of length variants in PRB genes is related to their greater ease of homologous but unequal pairing compared to PRH genes.

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Kuromaru, Tomoya, Hiroaki Kusunose et Yoshio Kuramoto. « Multipolar Ordering in PrB6 ». Journal of the Physical Society of Japan 71, Suppl (janvier 2002) : 130–32. http://dx.doi.org/10.1143/jpsjs.71s.130.

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Xu, Junqi, Yanrui Wang, Wenjie Wang, Zijun Xu, Yonglei Jia, Yandi Zhang, Minghui Huang, Lubin Wang, Fengyuan Liu et Wenhe Xie. « Growth of Large-Scale Praseodymium Hexaborides (PrB6) Nanowires and Enhanced Field-Emission Performance ». Journal of Nanoelectronics and Optoelectronics 15, n^o 2 (1 février 2020) : 276–83. http://dx.doi.org/10.1166/jno.2020.2722.

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Large-scale PrB6 nanowires were fabricated by an effective, catalyst-free, and a simple low-pressure chemical vapor deposition (LPCVD) process. These nanowires, characterized in detail by various analytical instruments, demonstrated the large aspect ratio and high single-crystalline grown along the [001] crystal direction perpendicular to the (001) crystal plane. The field electron emission equipment tests manifest that the asgrown PrB6 products have a low turn-on field (Eto, 2.32 V/μm), a threshold field (Ethr, 4.28 V/μm), a high field enhancement factor (β, 2336), as well as a stable current-density (J) of field-emission. The relationships of the field electron emission parameters, such as J, Eto, and β versus cathode gap (d), have been established when d is increased from 500 μm to 800 μm. The outstanding properties suggest that the PrB6 products may be promising emitters in the cold-field-emission cathode application.

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Sera, Masafumi, Satoru Kunii et Tadao Kasuya. « Oscillatory Magnetostrictions of LaB6and PrB6 ». Journal of the Physical Society of Japan 57, n^o 1 (15 janvier 1988) : 13–15. http://dx.doi.org/10.1143/jpsj.57.13.

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Loewenhaupt, M., et M. Prager. « Crystal fields in PrB6 and NdB6 ». Zeitschrift f�r Physik B Condensed Matter 62, n^o 2 (juin 1986) : 195–99. http://dx.doi.org/10.1007/bf01323430.

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Лазуков, В. Н., П. А. Алексеев, Н. Ю. Шицевалова et В. Б. Филиппов. « Температурная эволюция спектра магнитных возбуждений PrB6 ». Физика металлов и металловедение 117, n^o 5 (2016) : 478–84. http://dx.doi.org/10.7868/s0015323016050132.

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Ōnuki, Y., M. Nishihara, M. Sato et T. Komatsubara. « Fermi surface and cyclotron mass of PrB6 ». Journal of Magnetism and Magnetic Materials 52, n^o 1-4 (octobre 1985) : 317–19. http://dx.doi.org/10.1016/0304-8853(85)90290-2.

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Lazukov, V. N., P. A. Alekseev, N. Yu Shitsevalova et V. B. Philippov. « Thermal evolution of magnetic-excitation spectrum of PrB6 ». Physics of Metals and Metallography 117, n^o 5 (mai 2016) : 460–65. http://dx.doi.org/10.1134/s0031918x16050136.

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Kasuya, Tadao, et Hisatomo Harima. « Puzzle on the Fermi Surface in CeB6and PrB6 ». Journal of the Physical Society of Japan 65, n^o 7 (15 juillet 1996) : 1898–901. http://dx.doi.org/10.1143/jpsj.65.1898.

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Thèses sur le sujet "Prb6"

Bouvet, Alain. « Étude par diffusion inélastique de neutrons des propriétés magnétiques de borures de terre rare : CeB6, PrB6 et YbB12 ». Université Joseph Fourier (Grenoble ; 1971-2015), 1993. http://www.theses.fr/1993GRE10186.

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Cette thèse porte sur l'étude par diffusion inélastique de neutrons des propriétés magnétiques de borures de terre rare : ceb#6, prb#6 et ybb#1#2. La difficulté de réalisation des expériences, notamment la faiblesse des signaux due en partie à la forte absorption des neutrons par le bore, nous a conduit à inclure, dans un programme d'analyse, la correction d'absorption. La partie principale de cette thèse a été l'étude des interactions magnétiques dans les phases ordonnées de ceb#6 et prb#6. Nous avons confirmé la présence d'interactions magnétiques quadrupolaires importantes, grâce à la mesure des excitations magnétiques dans la phase quadrupolaire de ceb#6 en appliquant un champ magnétique dont la valeur était comprise entre 0 et 6 t, et dans les phases double-k et simple-k basse température de prb#6. De plus nous avons montré qu'il semble exister une compétition entre les interactions magnétiques quadrupolaires et les interactions magnétiques dipolaires dans le compose ceb#6, alors que les interactions quadrupolaires dans prb#6 semblent au contraire renforcer la structure magnétique dipolaire. Les mesures effectuées avec le compose ybb#1#2 nous ont permis de donner une valeur de 60 k pour l'énergie du gap, cette valeur étant conforme à celles obtenues par des mesures de résistivité et d'optique. De plus nous proposons un schéma de niveau de champ cristallin, avec le niveau fondamental #8 et les niveaux excites #7 et #6 a respectivement 18 et 39 mev. En annexe, nous présentons également les résultats obtenus par diffusion inélastique de neutrons avec le compose bidimensionnel xy bani#2(po#4)#2. Un programme a été développé pour déconvoluer les spectres mesures de la fonction de résolution instrumentale à 4 dimensions. Les largeurs intrinsèques, ainsi déterminées, de la diffusion magnétique critique ne montrent aucune caractéristique des excitations non linéaires prévues par la théorie, mais peut être expliqué uniquement par une renormalisation des ondes de spin

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Dagne, Carl. « Implementering av tillståndsmaskiner med PRBS ». Thesis, Linköping University, Department of Electrical Engineering, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1841.

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Tillståndsmaskiner är vanliga komponenter i många digitala konstruktioner. En vanlig typ av tillståndsmaskin är räknare. Räknare är ofta ganska kostsamma att implementera, med avseende på antalet grindar. För att reducera denna kostnad kan istället en PRBS (Pseudo Random Binary Sequence) användas. Denna byggs upp av ett register där en xor - operation utförs mellan två positioner, som beror på längden av registret. Resultatet från denna operation skiftas sedan in i registret. På detta sätt fås en till synes slumpmässig sekvens. Talen är dock inte på något sätt slumpmässiga utan kan hela tiden förutsägas. I detta examensarbete har en undersökning för att konstruera en billig tillståndsmaskin med hjälp av PRBS:er gjorts i MatLab. Tre olika program har skrivits för att beräkna olika kostnader vid implementering av en tillståndsmaskin.

Finite state machines are common components in digital designs. A common type of finite state machine is a counter. Counters are often quite expensive to implement, with respect to the number of gates. To reduce this cost, a PRBS (Pseudo Random Binary Sequence) can be used. It is constructed of a register where a xor - operation is performed between two positions, which depend on the length of the register. The result from this operation is then shifted back into the register yielding a random-like sequence. The numbers are not random, but can always be predicted. In this thesis work finite state machine using PRBS are designed in MatLab. Three different programs have been written to calculate the costs for implementation of a PRBS.

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Newton, B. T. « Applied gas tracing or permeable reactive barriers (PRBs) ». Thesis, Queen's University Belfast, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.602710.

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The aim of my thesis is to evaluate the use of applied dissolved noble gas tracers for the estimation of flow and transport parameters in permeable reactive barriers (PRBs) and for the assessment of changes in those parameters over time. PRBs consist of reactive materials that are p l aced in the subsurface to intercept a contaminant plume. PRBs have been proven to effectively remediate a variety of groundwater contaminants. The main limitation to the use PRBs as a remediation tool is the build up of mineral precipitates and gases that may inhibit water flow through the barrier, decrease the reactivity of the PRB medium, and reduce the residence time of contaminated water. Applied chemical tracers provide the most direct measurement of how water moves through PRBs to assess the effects of mineral precipitation and gas evolution on flow and transport parameters in PRBs. Tracer experiments in laboratory columns and full scale permeable reactive barriers are described in detail , highlighting advantages and disadvantages of using noble gases as applied tracers. The volatility of noble gases presents advantages and disadvantages. The retardation of dissolved gas tracers, as a result of interactions with gas bubbles trapped in pore spaces, provides information about the volume of a gas phase that is present in the system. However, the degassing of dissolved gas tracers during tracer injection, sampling , and sample preparation can result in many uncertainties with respect initial tracer concentrations. These uncertainties are best dealt with by using multiple noble gas tracers along with a "conservative" tracer such as Bromide or Chloride. This thesis demonstrates that noble gases can be used effectively as applied tracers to assess the long - term effectiveness of PRBs.

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ORRU', ROBERTO. « Sequenziamento e Analisi Molecolare di Varianti Alleliche del Gene PRB1 ». Doctoral thesis, Università degli Studi di Cagliari, 2016. http://hdl.handle.net/11584/266626.

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The aim of this work was the molecular characterization of gene PRB1 in three subjects with different salivary proteome profile. The PRB1 gene encodes a member of the heterogeneous family of Basic Proline rich Proteins (PRB), produced by the parotid gland and secreted in human saliva. The protein polymorphism resulting from post-translational modifications of the pre-protein PRB1, are further complicated by the gene allelic variants. Those variants involves the third exon of the gene, and are related to the presence or absence of a tandem repeat sequence 183 bp long. That tandem repeat may originate three different allelic forms, defined small, medium or large depending on the number of repeats inside the third exon. The information reported in the literature about the class of PRP genes, and in particular PRB1 are, from the molecular point of view, fragmentary and difficult to reconstruct. In fact, the literature on this topic covers a time span ranging from the seventies (Azen & Oppenheim, 1973), when the associated peptides have been characterized for the first time, up to the end of the nineties (Stubbs et al., 1998). Since the eighties, there have been various attempts to characterize the PRB1 allelic variants, based on the resulting peptides. This approach has greatly complicated the classification of the gene, but also of his allelic variants and the deriving proteins (Maeda et al., 1985 ; Lyons et al., 1988a, b; Azen et al., 1993). Today we know that from PRB1, considering its allelic and splicing variants, are expressed six different proteins (Marconi et al., 2015). However, amongst the three allelic variants of this gene, the only of which we have the complete nucleotide sequence is the medium. Conversely, for the small and large we have so far only partial sequences, referring only to the third exon. Among the objectives of this study, there was the reconstruction of the complete sequences of the small and large variants, of which there have been previously characterized two putative bearers from the proteomic point of view. At the same time, we also sequenced the PRB1 gene from a putative homozygotic bearer of the medium variant. While for the subject bearer of the small variant, we were able to identify and sequence the entire gene, the same was not possible for the subject bearer of the large variant. In fact, from our analysis this last subject has shown to be homozygous carrier of the medium variant. This result is incompatible with the presence in his saliva of Ps2 protein, which is characteristic of the large variant. In the absence of further mass spectrometric analysis, we cannot explain the reason for this discrepancy between genomic and proteomic data. The analysis of the complete sequences did not allow us to understand why it has not been identified to the mass spectrometer the peptide relative to the splice variant classified by Maeda with the acronym cP5 (Maeda et al., 1985), while in all the subject has been identified the peptide and the relative cP4 splice variant. Pk-o protein has so far been reported to be expressed from the large variant only, although the first classification of splice variants had been made from an individual carrying the medium variant. Since in none of the three sequenced subjects the splice acceptor site in 3' of the cP5 variant results to be altered, it is possible that the relative peptide has not been identified to the mass spectrometer. Otherwise, specific splicing factors, that recognize Splicing Regulatory Elements (SRES; Hernandez-Imaz et al., 2015) in the neighborhood of the two molecular acceptor sites, prevented the transcription of the cP5 in favor of cP4. In order to shed light on this aspect, there are some possible strategies in perspective. Recently, in fact, studies have been published in which extensive in vivo screening for the detection of SRES is coupled with RNA affinity purification and mass spectrometry, which allow also the identification of the splicing factors which bound to the SRES (Wang Y & Z Wang, 2014; Wang et al., 2013). This strategy could be effectively integrated with the analysis of minigenes (Hernandez-Imaz et al., 2015), specifically designed on the model of the third exon of PRB1, where alternative splicing takes place and where are probably placed the SRES. Molecular analysis has also enabled us to identify a set of Single Nucleotide Polymorphims (SNPs), most of which have never been described so far, localized specially inside introns and some even within exons. In particular, for two of these, we have detected a non-synonymous substitution at the amino acid level, the role of which can only be clarified by means of appropriate functional studies. Although translationally silent, even synonymous SNPs may have an important function, especially in alternative splicing. In fact, these substitutions can determine the genesis or destruction of SRES, or strengthen cryptic donor /acceptor sites. Furthermore, they can result in the alteration of the secondary structure of the mRNA, important for the exons definition and the pause sites of RNA II. This could, in turn, alter the processivity of the polymerase, with possible consequences on the choice of splicing sites. The reconstruction of the complete sequences and the comparison with the data available in the literature (Lyons et al., 1988) allowed us to produce an updated model, which allows to explain the generation of allelic variants small and large from the medium variant. Hopefully, the reconstruction also of the large allelic variation, and possibly the very large, will lay the basis for the validation of our model and possibly also its extension to other allelic variants of the PRB gene class. The genotypic characterization of allelic variants of PRB1 may be, in the future, an important predictive tool about the subjective susceptibility towards a series of oral pathogens. In fact, polymorphic variations in the PRB1 peptides can build the basis for the prediction of individual differences at the level of the oral microflora, with repercussions on the susceptibility to infections and diseases in this body part (Newman et al., 1993 and 1996; O'Sullivan et al., 2000).

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Kalpathy, Venkiteswaran Venkatasubramanian. « Development of a Design Framework for Compliant Mechanisms using Pseudo-Rigid-Body Models ». The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1482232749828813.

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Sun, Ang. « Anti-cancer Functions and Mechanisms of a pRb2/p130 Peptide Fragment ». Diss., Temple University Libraries, 2009. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/58962.

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Biology
Ph.D.
The spacer region of pRb2/p130 was reported to be able to inhibit the kinase activity of Cdk2. The region responsible for the inhibitory effect was further narrowed down to a 39-amino-acid sequence, which was named as Spa310. In this dissertation, the anti-cancer functions and mechanisms of Spa310 were studied. The synthesized Spa310 peptide was able to inhibit the kinase activities of Cdk2/Cyclin E/A complexes. In vitro kinase assays showed the inhibition occurred in a dose-dependent manner. The half maximal inhibition concentration of the Spa310 in the kinase assay was 1.67mM. In addition, it has been shown that Spa310 peptide is able to inhibit the kinase activities of both Cdk2/Cyclin E and Cdk2/Cyclin A. Intra-cellular distribution study using fluorescein-labeled Spa310 peptide showed that Spa310 was able to localize to the nuclei of A549 cancer cells. Some data indicated the endoplasmic reticulum might play a role in transporting Spa310 peptide from cytoplasm to the nucleus. At high concentration, the treatment of Spa310 peptide was able to arrest cells at the G0/G1 phase of the cell cycle and reduce the growth of xenografted tumors in nude mice. Further studies indicated Spa310 peptide is not a specific inhibitor for Cdk2/Cyclin E/A. It is also able to inhibit the kinase activities of Cdk1/Cyclin B, Cdk4/Cyclin D and Cdk9/Cyclin T/K. Result of a binding assay using GST-Spa310 and in vitro transcribed/translated Cdk2 did not support a direct binding between Spa310 and Cdk2. Additionally, GST-Spa310 was unable to bind to the in vitro transcribed/translated Cyclin E. At first, co-immunoprecipitation experiments indicated a weak binding between Spa310 peptide and Cdk2. However, later this weak binding was proven to be unspecific and only occurred when the concentration of Spa310 peptide was high. Thus, the hypothesized mechanism of the inhibitory effect of Spa310 was not supported. After noticing three classic Cdk phosphorylation sites present in Spa310, it was proven that Spa310 is a substrate for Cdk1, 2, 4 and 9. Results of kinase assays supported the inhibitory effect of Spa310 on the different Cyclin-dependent kinases was resulted from a substrate-competitive mechanism. Although the data generated from this study does not support Spa310 is a potent peptide inhibitor for the Cdks, knowledge gained from and the approach used in this research can be applied to design and develop more potent and specific Cdk2 peptide inhibitors, which have their potentials to work as powerful anti-cancer reagents.
Temple University--Theses

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STUCCHI, SIMONE. « Role of glucose and peroxiredoxin 6 in human chondrocytes and novel biomaterial for in vitro three-dimensional chondrocytes culture ». Doctoral thesis, Università degli Studi di Milano-Bicocca, 2020. http://hdl.handle.net/10281/261927.

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L’osteoartrite (OA) è una delle malattie reumatiche con più alta incidenza nel mondo moderno e rappresenta la pricipale cause di disabilità. L’OA è data da un disquilibrio tra degradazione e riparazione della cartilagine, a favore della degradazione, con un incremento dell’attivita degli enzimi catabolici come le matrici metalloproteinasiche. I condrociti sono responsabili della riparazione e della biosintesi degli elementi che compongono la ECM. Diversi studi supportano l’ipotesi che il diabete è uno dei fattori che causano l’osteoartrite. Sebbene non si conoscono ancor ai meccanismi molecolari che permettano l’associazione tra diabete e OA. Abbiano analizzato la crescita cellulare, i livelli dei ROS e l’apoptosi di condrociti posti in terreno con differenti concentrazioni di glucosio. I risultati mostrano che i condrociti preferiscono la concentrazione 2.5 mM di glucosio che è stata utilizzata come concentrazione normoglicemica; mentre 25 mM di glucosio è stata utilizzata come concentrazione iperglicemica. I livelli di ROS e la morte cellulare aumentano in condrociti cresciuti in alto glucosio, anche il citoscheletro si presenta disorganizzato in cellule C28/I2 cresciute in queste condizioni. Questo correla con lo stato di attivazione della GTPasi RalA, la cui attivazione è ridotta in condizioni iperglicemiche. Infatti questa GTPasi è coinvolta nella regolazione della riorganizzazione citoscheletrica. Inoltre sono stati effettuati esperimenti utilizzando medium contenenti ITS (Insulina, transferrina e selenio) che pruomuove il differenziamento a condrocita; mentre l’interleuchina-1β per simulare l’ambiente osteoartritico. Anche in uesto caso i livelli di RalA GTP diminuiscono in cellule cresciute in 25 mM glucosio e stimolate con IL-1β. Inoltre in queste condizioni diminuiscono ache i livelli di p-ERK1/2. Sono stati valutati anche i livelli di NF-κB, iNOS e LC3II. I risultati dimostrano che l’alto glucosio blocca l’autofagia nei condrociti. Inoltre sono stati valutati anche i pathways attivati dall’alto glucosio in condrociti primari umani dopo 24 h di trattamento. I risultati mostrano che la fosforilazione di ERK1/2, p38, Akt e p65 è alterata in condrociti cresciuti in condizioni iperglicemiche tale evento è correlato con un aumento di MMP-13. Per analizzare meglio il ruolo dei ROS nei condrociti ho lavorato per 6 mesi nel laboratorio del Dr. Loeser alla scuola di medicina presso l’università della north Carolina a Chapel Hill. Ho lavorato su PRX6 che è coinvolto nella detossificazione dai ROS. Lo stato di ossidazione di PRX6 è stato valutato nei condrociti trattati con diversi stimoli come H2O2, Fn-f, menadione (men) and DMNQ. Dopo questi esperimenti abbiamo voluto osservare se PRX6 potesse influenzare i pathway delle MAPK in cellule trattate con IGF-1, menadione, combinazione tra IGF-1 e menadione e con Fn-f. è stata valutata la localizzazione di PRX6 che si è visto essere sia nucleare che citoplasmatico. Inoltre ho lavorato in collaborazione con Prof. Laura Cipolla e Prof. Maddalena Collini per sviluppare e caratterizzare nuovi idrogel fatti di gelatina usando come agente cross-linkante lo squarato.
Osteoarthritis (OA) is the most common rheumatic disease in the world and represents the first cause of disability in the world. OA results from the loss of balance between degradation and repair inside cartilage, in favor of degradation, with increased activity of catabolic enzymes such as matrix metalloproteinases and decreased production of ECM proteins. Chondrocytes are responsible for the repair and biosynthesis of elements of the extracellular matrix. Experimental findings support the hypothesis that diabetes is an independent risk factors for OA. However, correct molecular mechanisms underlying the diabetes-associated OA phenotype is still largely unknown. Firstly chondrocytes cell growth, ROS levels and apoptosis were analyzed using different glucose concentration. Results shown that chondrocytes prefer 2.5 mM of glucose which was used as normal glucose concentration and 25 mM of glucose was used as high glucose concentration. ROS levels and cell death increase in chondrocytes growth in high glucose environment. Also cytoskeletal network is more disorganized in C28/I2 cells growth at high glucose concentration, this correlates with different RalA-GTP levels which is involved in the regulation of cytoskeletal organization. Experiments were performed even using medium supplemented by ITS (Insulin-transferrin-selenium) to promote chondrocyte differentiation and IL-1β was used to simulate osteoarthritic cartilage environment. Ral A-GTP levels are lower in cells grown in 25 mM of glucose and stimulated with IL1β. Levels of p-ERK1/2 decrease in cells grown at high glucose concentration and in cells stimulated with IL1β. Furthermore, NF-κB, iNOS and LC3II levels were evaluated. Results demonstrate that high glucose media block autophagic process in chondrocytes. Effect of glucose concentration on human primary chondrocytes cells was evaluated after only 24 h to understand which signaling pathways is activated by high glucose environment. Phosphorylation of ERK1/2, p38, Akt and p65 is altered in chondrocytes growth at high glucose concentration and this correlates with an increase secretion of MMP-13. To better analyze the role of ROS levels in the chondrocytes I worked for 6 months in the Dr. Loeser Lab at the School of Medicine in the University of North Carolina at Chapel Hill; one of the best lab in the cartilage biology field. I worked on PRX6 which is involved in the recovery from H2O2. Oxidation state of PRX6 was evaluated in chondrocytes treated with different stimuli, like H2O2, Fn-f, menadione (men) and DMNQ. After this experiment, we wanted to see if PRX6 could impact the MAPK signaling pathways in cells treated with IGF-1, menadione, combination of menadione and IGF-1 and with Fn-f. Localization of PRX6 was analyzed using nuclear and cytoplasm extraction. Then I worked in collaboration with Prof. Laura Cipolla and Prof. Maddalena Collini to develop and characterized a new gelatin-based hydrogel using Diethylsquarate as crosslinker.

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Gong, Mingrui. « Multivariable system controller tuning techniques based on sensitivity measures ». Thesis, University of Glasgow, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312434.

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Kato, Gabriel Fukunaga. « Avaliação da expressão imuno-histoquímica das proteínas p53 e pRB em ameloblastomas e tumores odontogênicos queratocísticos ». Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/23/23141/tde-19012016-155909/.

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Tumores odontogênicos constituem grupo abrangente de afecções tumorais, sendo ameloblastomas e tumores odontogênicos queratocísticos as lesões benignas de maior frequência, cujas características biológicas são pouco conhecidas. Objetivo do presente estudo foi avaliar o perfil imuno-histoquímico das proteínas pRB e p53 em ameloblastoma e tumor odontogênico queratocístico. Foram avaliadas amostras de material parafinado de 21 casos de ameloblastoma e de 20 casos de tumor odontogênico queratocístico para ensaio de imuno-histoquímica com os anticorpos anti-pRB e anti-p53. A contagem da imuno-marcação foi realizada a partir de fotografias de alta resolução processadas no software ImageJ para quantificação manual em campo de 1000 células. A localização da imuno-marcação para ambos anticorpos foi semelhante, sendo em ameloblastomas predominantemente nas células da periferia e, em tumores odontogênicos queratocísticos, nas camadas suprabasais. Quantitativamente, as porcentagens de células marcadas foram estatisticamente maior nos ameloblastoma para anti-p53 (p=0,01) e maior nos tumores odontogênicos queratocísticos para anti-pRB (p=0,04). Não houve correlação estatística entre a porcentagem de células marcadas para anti-p53 e anti-pRB nos ameloblastomas, porém, esta correlação foi positiva e moderada nos tumores odontogênicos queratocísticos (r=0,537; p=0,018). Nota-se ligeira diferença na quantificação das imuno-marcações para o anti-p53 e anti-pRB. Tais resultados devem ser ponderados pela reduzida casuística, porém, sugerem perfis distintos em mecanismos biológicos determinantes para ambos os tumores.
Odontogenic tumors are a comprehensive group of tumor diseases, being ameloblastomas and keratocystic odontogenic tumors the most frequent benign odontogenic tumors. Their biological characteristics are little unknown. The aim of present study was to evaluate the immunohistochemical profile of pRB and p53 proteins in 21 cases of ameloblastomas and 20 cases of keratocystic odontogenic tumors for anti-pRB and anti-p53 antibodies. The quantification of immunostaining was performed manually with high-resolution photographs processed in the ImageJ software to quantify positive cells in a 1000 cells-field. The location of immunostaining for both antibodies was similar. In ameloblastomas, positive cells are located mainly in the peripheral layers, whereas in keratocystic odontogenic tumors the positive cells are located in the suprabasal layers. Quantitatively, the percentage of labeled cells was statistically higher in ameloblastomas for anti-p53 (p = 0.01) and higher in keratocystic odontogenic tumors for anti-pRB (p = 0.04). There was no statistical correlation between the percentage of labeled cells to anti-p53 and anti-pRB in ameloblastomas, however, its correlation was positive and moderate in keratocystic odontogenic tumors (r = 0.537; p = 0.018). It is possible to identify a slight difference in immuno-quantification for anti-p53 and anti-pRB among these lesions. These results must be pondered by the small sample, however, is suggests a different profile in a preponderant key biological mechanisms for odontogenic tumors.

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Chan, Ho Man. « Molecular basis of cell cycle control : p300 and pRb ». Thesis, University of Glasgow, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326430.

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Livres sur le sujet "Prb6"

Cheetham, R. G. Power system plant modelling from PRBS experiments. Sheffield : University,Dept. of Control Engineering, 1986.

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Mills, John W. Sculpture and drawings by John W. Mills PRBS. London : King Street Galleries, 1986.

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D'Abreo, Cheryl Ann. Structural domains of p107, a pRB family protein. Ottawa : National Library of Canada, 1996.

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Kha, Lan-Chau Thi. Characterization of pRb and TFIIB binding by hSSU72 transcription factor. Ottawa : National Library of Canada, 2003.

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Liu, Fei, Guoxin Huang, Howard Fallowfield, Huade Guan, Lingling Zhu et Hongyan Hu. Study on Heterotrophic-Autotrophic Denitrification Permeable Reactive Barriers (HAD PRBs) for In Situ Groundwater Remediation. Berlin, Heidelberg : Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-38154-6.

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Rahman, Shamsur. Bāṃlādeśera Puliśa Prabidhānera bhāshya = : Commentary on the Police Regulation of Bengal, PRB. Ḍhākā : Pepāra Prasesiṃ eyāṇḍa Pyākejiṃ, 1992.

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Andreescu, Titu, et Zuming Feng, dir. Mathematical Olympiads. Providence, Rhode Island : American Mathematical Society, 2000. http://dx.doi.org/10.1090/prb/003.

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Andreescu, Titu, et Zuming Feng, dir. USA and International Mathematical Olympiads 2000. Providence, Rhode Island : American Mathematical Society, 2001. http://dx.doi.org/10.1090/prb/004.

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Andreescu, Titu, et Zuming Feng, dir. Mathematical Olympiads 1999-2000. Providence, Rhode Island : American Mathematical Society, 2003. http://dx.doi.org/10.1090/prb/005.

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Andreescu, Titu, et Zuming Feng, dir. USA and International Mathematical Olympiads of 2001. Providence, Rhode Island : American Mathematical Society, 2002. http://dx.doi.org/10.1090/prb/007.

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Chapitres de livres sur le sujet "Prb6"

Villars, P., K. Cenzual, J. Daams, R. Gladyshevskii, O. Shcherban, V. Dubenskyy, V. Kuprysyuk et I. Savysyuk. « Cs4[Pr6(C2)]I13 ». Dans Structure Types. Part 9 : Space Groups (148) R-3 - (141) I41/amd, 822. Berlin, Heidelberg : Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-02702-4_595.

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Choksi, Nishaant. « Pragmatics of script ». Dans Handbook of Pragmatics, 181–98. Amsterdam : John Benjamins Publishing Company, 2020. http://dx.doi.org/10.1075/hop.22.pra6.

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Sang, Nianli, et Antonio Giordano. « Cell Cycle Genes : pRb and p53 ». Dans When Cells Die II, 339–79. Hoboken, NJ, USA : John Wiley & Sons, Inc., 2005. http://dx.doi.org/10.1002/0471476501.ch14.

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Zhao, Lixin, Xiaodong Wang et Zhiwu Liu. « Research on PRB Technology for Groundwater Remediation ». Dans Environmental Pollution Governance and Ecological Remediation Technology, 691–96. Cham : Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-25284-6_73.

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Yang, Zhijie, Lei Wang, Xiangyu Zhang, Dong Ding, Chuan Xie et Li Luo. « PRBN : A Pipelined Implementation of RBN for CNN Training ». Dans Communications in Computer and Information Science, 117–31. Singapore : Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-8135-9_9.

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« PRBP ». Dans Encyclopedia of Signaling Molecules, 4124. Cham : Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_103045.

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« PRBC ». Dans Encyclopedia of Trauma Care, 1282. Berlin, Heidelberg : Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-29613-0_101200.

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« pRb ». Dans Encyclopedia of Signaling Molecules, 4124. Cham : Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_103044.

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« pRB ». Dans Encyclopedia of Genetics, Genomics, Proteomics and Informatics, 1546. Dordrecht : Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-6754-9_13354.

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« pRB ». Dans Encyclopedia of Cancer, 3680. Berlin, Heidelberg : Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-46875-3_102471.

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Actes de conférences sur le sujet "Prb6"

Kuo, Chin-Hsing, Yen-Chun Chen et Ta-Yu Pan. « Continuum Kinematics of a Planar Dual-Backbone Robot Based on Pseudo-Rigid-Body Model : Formulation, Accuracy, and Efficiency ». Dans ASME 2017 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/detc2017-67853.

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This paper introduces a pseudo-rigid-body-model (PRBM) approach for analyzing the kinematics of a planar dual-backbone continuum robot. Unlike common load-displacement PRBM studies, the presented PRBM approach is tailor-made for the displacement-displacement analysis of compliant mechanisms, where the relationship between the lengths of the “backbone” wires and the pose of the robot is to be explored. Based on a PRB 3R modelling, the forward kinematics of the robot can be formulated as a nonlinear system of eight equations. To validate the accuracy and efficiency of the approach, a series of case studies are performed via ANSYS simulation and experiments. The results show that 1) the computation time for solving forward kinematics via the PRB 3R approach is less than 0.16% of that via ANSYS simulation; 2) the maximum percentage position errors of the PRB 3R model are 0.47% and 1.96% in the x- and y-directions, respectively; and 3) the maximum percentage orientation error of the PRB 3R model is 2.23%, as compared with ANSYS simulation results. As a result, the proposed PRBM approach delivers a satisfied compromise between accuracy and efficiency for the kinematic analysis of the planar dual-backbone continuum robot.

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Choi, J., et S. L. Lee. « Effects of Precipitation on the Low-Frequency Electrical Properties of PRB : Implications for Monitoring PRBs ». Dans 80th EAGE Conference and Exhibition 2018. Netherlands : EAGE Publications BV, 2018. http://dx.doi.org/10.3997/2214-4609.201800830.

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Zhai, Xuemeng, Hangyu Hu, Guangmin Hu et Youyang Qu. « PRBL ». Dans ACM TURC 2019 : ACM Turing Celebration Conference - China. New York, NY, USA : ACM, 2019. http://dx.doi.org/10.1145/3321408.3326678.

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Chen, Guimin, et Aimei Zhang. « Accuracy Evaluation of PRBM for Predicting Kinetostatic Behavior of Flexible Segments in Compliant Mechanisms ». Dans ASME 2011 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2011. http://dx.doi.org/10.1115/detc2011-47117.

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The pseudo-rigid-body model (PRBM) method has been widely accepted as one of the most important tools for synthesis and analysis of compliant mechanisms. However, the lack of quantitative study on the accuracy of PRBM for predicting the kinetostatic behavior of flexible members always makes users feel unconfident in the results achieved by PRBM. In this paper, a strain-energy-based approach is proposed for evaluating the accuracy of PRBM for predicting kinetostatic behavior of flexible segments, which compares the results of strain energy calculate using PRBM to those obtained using the derived closed-form solutions. The approach was used to evaluate the accuracy of the PRBM for flexible cantilever beams. It is proved that the PRBM is accurate for modeling segments subject to end-moment loads. A thorough comparison for segments subject to end-force loads is also presented. The results could be useful for PRBM users to assess the accuracy of the models for their compliant mechanism designs, or to choose appropriate values for the characteristic parameters. The results may also be used to improve the PRBM.

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Jagirdar, Saurabh, et Craig P. Lusk. « Preliminaries for a Spherical Compliant Mechanism : Pseudo-Rigid-Body Model Kinematics ». Dans ASME 2007 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2007. http://dx.doi.org/10.1115/detc2007-34782.

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The kinematic portion of a pseudo-rigid-body model (PRBM) is developed as a generalization from planar to spherical mechanisms. The topology of the spherical compliant segment and its rigid-body equivalent are derived from planar models by analogy. The nomenclature for the spherical PRBM is chosen to facilitate comparison with the planar PRBM. The motion of the compliant segment is calculated using FEA and PRBM parameters are determined. The characteristic radius and parametric angle coefficient are found to decrease as the angle subtended by the beam increases. The parameterization limit increases with increasing beam angle. The spherical PRBM is identical to the planar PRBM in the limiting case when beam angles become very small.

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Leo´n, Alejandro, Saurabh Jagirdar et Craig P. Lusk. « A Pseudo-Rigid-Body Model for Spherical Mechanisms : The Kinematics and Stiffness of a Compliant Curved Beam ». Dans ASME 2008 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2008. http://dx.doi.org/10.1115/detc2008-49769.

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A pseudo-rigid-body model (PRBM) which describes a class of curved compliant beams in terms of spherical mechanism kinematics was developed. The topology of the spherical compliant segment and its rigid-body equivalent were chosen to be analogous to planar models. The nomenclature for the spherical PRBM was also chosen to facilitate comparison with planar models. The motion of the compliant segment was calculated Finite Element Analysis and the PRBM parameters were determined. The characteristic radius and parametric angle coefficient were found to decrease as the angle subtended by the beam increases. The kinematic and elastic parameterization limits of the model increase with increasing beam angle. The stiffness of the beam is described by two separate spring elements, which describe the appropriate combination of moment and force which produces spherical motion. A previous planar PRBM is shown to be the small angle limit of the new spherical PRBM.

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Lusk, Craig P. « Quantifying Uncertainty for Planar Pseudo-Rigid Body Models ». Dans ASME 2011 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2011. http://dx.doi.org/10.1115/detc2011-47456.

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The Pseudo-Rigid-Body Model (PRBM) is an important technique for analyzing and synthesizing compliant mechanisms. This paper describes an approach for generalizing the PRBM and for quantifying its accuracy. The Bernoulli-Euler beam equations are solved and the solution is represented using a phase-portrait. It is shown that the slope-curvature relations for all uniform fixed free-beams can be represented on a single phase portrait. This representation allows for data about PRBM representations for each cantilever beam to be efficiently presented, and for broad conclusions to be drawn, e.g. that the relative position error associated with a simple version of the PRBM is never greater than 7%.

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Mattson, Christopher A., Larry L. Howell et Spencer P. Magleby. « Development of Commercially Viable Compliant Mechanisms Using the Pseudo-Rigid-Body Model : Case Studies of Parallel Mechanisms ». Dans ASME 2001 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2001. http://dx.doi.org/10.1115/imece2001/ad-23718.

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Abstract Analysis and synthesis of compliant mechanisms has recently been the subject of significant study in the research community. This focus has led to a number of design approaches for developing compliant mechanisms. This paper describes the value of using the Pseudo-Rigid-Body Model (PRBM) to design compliant mechanisms for commercial products. Application of the PRBM is illustrated through the development of two parallel mechanisms: a bicycle derailleur and parallel-motion bicycle brakes. The PRBM allows compliant mechanisms to be modeled and analyzed as rigid-body mechanisms and significantly reduces the complexity of analysis. Mechanisms with straightforward properties are used to demonstrate the use of the PRBM to design commercially viable compliant mechanisms for required motion and force-deflection characteristics.

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Poustie, A. J., K. J. Blow, R. J. Manning et A. E. Kelly. « All-optical pseudorandom bit sequence generator ». Dans The European Conference on Lasers and Electro-Optics. Washington, D.C. : Optica Publishing Group, 1998. http://dx.doi.org/10.1364/cleo_europe.1998.cpd2.2.

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The ability to perform all-optical digital information processing is one of the key requirements for future photonic networks. Recently, the use of semiconductor optical amplifier based all-optical interferometric switches [1] has allowed practical demonstrations of advanced functionality to be demonstrated. These have included a bit-serial regenerative optical memory which is capable of long term storage [2] and has the ability to restore the optical logic level [3]. Here we describe a further advance in all-optical digital functionality with a demonstration of an all-optical pseudorandom bit sequence (PRBS) generator. The all-optical PRBS comprises two coupled regenerative memories [2] which act as a time-of-flight shift register for optical pulses. A digital PRBS can be generated by applying the logical XOR function between the output of the register and a tap point and feeding the logical result back into the start of the register [4]. We use two TOAD all-optical switching gates [5] to create the all-optical PRBS architecture. One TOAD is used for the XOR function and the other acts as a wavelength converter and all-optical regenerator. The PRBS output depends on the number of pulses m in the shift register and the tap position n (n<m). At present, the experimental latency is several hundred bits at a IGHz clock rate and so we use multiples of lower length sequences in order to measure the performance of the design. We have experimentally demonstrated a maximal length 231-1 PRBS ({m,n}={713,552} ≡ 23 x {m,n}={31,24}) and also sub-maximal sequences. The figure below shows a digitally sampled part of the maximal 231-1 PRBS. The apparent amplitude modulation of the pulses is an artefact of the relatively low sampling rate (400Msamples/s). We were only able to record short temporal sequences since the repeat period of the PRBS is ~50s.

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Logan, Philip J., et Craig P. Lusk. « Pseudo-Rigid-Body Models for End-Loaded Heavy Cantilever Beams ». Dans ASME 2015 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/detc2015-46526.

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The large deflection of cantilever beams has been widely studied. A number of models and mathematical techniques have been utilized in predicting the path coordinates and load-deflection relationships of such beams. The Pseudo-Rigid-Body Model (PRBM) is one such method which replaces the elastic beam with rigid links of a parameterized pivot location and torsional spring stiffness. In this paper, the PRBM method is extended to include cases of a constant distributed load combined with a parallel endpoint force. The phase space of the governing differential equations is used to store information relevant to the characterization of the PRBM parameters. Correction factors are also given to decrease the error in the load-deflection relationship and extend the angular range of the model, thereby further aiding compliant mechanism design. Our calculations suggest a simple way of representing the effective torque caused by a distributed load in a PRBM as a function of easily calculated model parameters.

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Rapports d'organisations sur le sujet "Prb6"

Jenkins, W. J. Task plan for test of PRBT prototypic liquid sampler. [Precipitate Reactor Bottom Tank (PRBT)]. Office of Scientific and Technical Information (OSTI), février 1992. http://dx.doi.org/10.2172/7066405.

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Rutherford, Benjamin, Andrew Collins, Zachary Tyler, Patrick Border, Stanley Boc et Timothy Rushing. Full-scale trafficability testing of prototype submersible matting systems. Engineer Research and Development Center (U.S.), octobre 2023. http://dx.doi.org/10.21079/11681/47701.

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This report describes the full-scale evaluation of prototype submersible matting systems (SUBMAT) at a test site at the US Army Engineer Research and Development Center’s Vicksburg, Mississippi, site. The SUBMAT prototypes were designed to bridge the gap between high and low tide at a beach interface to enable 24-hour operation at an expeditionary watercraft landing site. This phase of the SUBMAT prototype development was intended to determine prototype system durability by applying military vehicle loads representing a combat brigade insertion across a littoral zone. The two mat systems evaluated in this study were the PYRACELL Road Building System (PRBS) and a basaltic rebar mat system. The results of the study showed that the PRBS system was able to sustain 1,000 Medium Tactical Vehicle Replacement, 350 Heavy Expanded Mobility Tactical Truck, and over 150 M1A1 main battle tank passes without significant damage. The basaltic rebar mat failed early in the test and was removed from further consideration for the SUBMAT application. Observations and lessons learned from this phase of the prototype PRBS development will be used to improve the PRBS design and modify its installation procedures for improved efficiency.

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Skone, Timothy J. PRB Coal Surface Mine Assembly, Construction. Office of Scientific and Technical Information (OSTI), février 2010. http://dx.doi.org/10.2172/1509031.

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Jenkins, W. J. Task plan for test of PRBT prototypic liquid sampler. Revision 1. Office of Scientific and Technical Information (OSTI), février 1992. http://dx.doi.org/10.2172/10185045.

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Skone, Timothy J. Surface Mine, Wyoming Northern PRB Subbituminous Coal, Operations. Office of Scientific and Technical Information (OSTI), juillet 2011. http://dx.doi.org/10.2172/1509200.

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Skone, Timothy J. Surface Mine, Wyoming Southern PRB Subbituminous Coal, Operations. Office of Scientific and Technical Information (OSTI), juillet 2011. http://dx.doi.org/10.2172/1509201.

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Borden, Robert C. Development of Permeable Reactive Barriers (PRB) Using Edible Oils. Fort Belvoir, VA : Defense Technical Information Center, juin 2008. http://dx.doi.org/10.21236/ada495565.

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Skone, Timothy J. Coal-Loading Silo, 12,000 Tons, Powder River Basin (PRB), Construction. Office of Scientific and Technical Information (OSTI), février 2010. http://dx.doi.org/10.2172/1509014.

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Boothroyd, A. T., J. P. Hill, D. F. McMorrow, N. H. Andersen, A. Stunault, C. Vettier et T. Wolf. Incommensurate magnetism in non-superconducting PrBa{sub 2}Cu{sub 3}O{sub 6.92}. Office of Scientific and Technical Information (OSTI), décembre 1998. http://dx.doi.org/10.2172/307971.

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Lim, Carol S. Agonist-Occupied PRA Represses PRB via Interactions with Coactivators or Corepressors. Fort Belvoir, VA : Defense Technical Information Center, juillet 2002. http://dx.doi.org/10.21236/ada408993.

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