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Articles de revues sur le sujet « Pro-liposome »

Auteur : Grafiati

Publié le 7 juin 2025

Mis à jour le 2 août 2025

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1

Yadav, Chandan, Md Asif, Juber Akhtar, et al. "An outline on curcumin: Its pro-liposome and liposome formulations." RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY 13, no. 12 (2020): 6276–83. http://dx.doi.org/10.5958/0974-360x.2020.01092.6.

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Hirose, Masanori, Shigenori Sugisaki, Keishi Suga, and Hiroshi Umakoshi. "Detection of L-Proline-Catalyzed Michael Addition Reaction in Model Biomembrane." Journal of Chemistry 2019 (February 26, 2019): 1–8. http://dx.doi.org/10.1155/2019/4926435.

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A method to detect the L-proline- (L-Pro-) catalyzed Michael addition reaction in model biomembranes has been established, using N-[p(2-benzimidazolyl)phenyl]maleimide and acetone as reactants. The effect of liposome membranes on this reaction was kinetically analyzed using fluorescence spectroscopy. The kinetics of the reaction were different from those of the constituent lipids of the liposomes. Zwitterionic 1,2-dipalmitoyl-sn-glycero-3-phosphocholine liposome, which is in the solid-ordered phase, had a better value of reaction rate, suggesting that the reaction rate constants of this reacti

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Prajakta, Kangutkar* Samruddhi More Shital Kambale Dr. D. R. Jadage. "A Review: Proliposomes As Effective and Stable Drug Delivery System." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 1021–30. https://doi.org/10.5281/zenodo.15352388.

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A new medication delivery method called proliposomes uses dry, granular materials that, when hydrated, produce liposomal solutions. Enhanced stability, prolonged drug release, and better bioavailability are all provided by them. Size, in vitro drug release, and trapping effectiveness are characteristics of proliposomes, which can be made in a variety of ways. They may find use in pulmonary, topical, and oral administration, especially for medications that are poorly soluble. By offering targeted distribution, proliposomes can increase treatment efficacy and lessen adverse effects. They are a d

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Sanchez-Aranguren, Lissette, Milda Grubliauskiene, Hala Shokr, et al. "Sodium Thiosulphate-Loaded Liposomes Control Hydrogen Sulphide Release and Retain Its Biological Properties in Hypoxia-like Environment." Antioxidants 11, no. 11 (2022): 2092. http://dx.doi.org/10.3390/antiox11112092.

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Hypoxia, or insufficient oxygen availability is a common feature in the development of a myriad of cardiovascular-related conditions including ischemic disease. Hydrogen sulphide (H2S) donors, such as sodium thiosulphate (STS), are known for their cardioprotective properties. However, H2S due to its gaseous nature, is released and cleared rapidly, limiting its potential translation to clinical settings. For the first time, we developed and characterised liposome formulations encapsulating STS and explored their potential for modulating STS uptake, H2S release and the ability to retain pro-angi

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Zhang, Ying, Haijing Qu, and Xiangdong Xue. "Blood–brain barrier penetrating liposomes with synergistic chemotherapy for glioblastoma treatment." Biomaterials Science 10, no. 2 (2022): 423–34. http://dx.doi.org/10.1039/d1bm01506k.

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A temozolomide and pro-apoptotic peptide co-loading liposome with blood–brain barrier penetrating capability exhibits highly synergistic and effective anti-tumor effect on both subcutaneous and intracranial glioblastoma mouse models.

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Lu, Yuan, Dankui Liao, Xuezhen Feng, et al. "Development and Adsorption Characterization of Metal Affinity-Immobilized Magnetic Liposome." Journal of Nanomaterials 2020 (February 11, 2020): 1–8. http://dx.doi.org/10.1155/2020/8731360.

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A metal affinity-immobilized magnetic liposome (MA-IML) was prepared in this research, which was with lipid and Ni2+ content of 143.25 μg/mg and 32 μmol/mg, respectively. The antihypertensive peptides Ile-Pro-Pro (IPP) and Val-Pro-Pro (VPP) could be adsorbed onto MA-IML under specific conditions, and the adsorption kinetics was explored. The pseudo-second-order kinetics (R2 value>0.98) was more suitable to describe the adsorption process of IPP and VPP than the intraparticle diffusion model and pseudo-first-order kinetic model. The results indicated that MA-IML could be used as an adsorbent

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An, Duopeng, Xiaochen Yu, Lijing Jiang, et al. "Reversal of Multidrug Resistance by Apolipoprotein A1-Modified Doxorubicin Liposome for Breast Cancer Treatment." Molecules 26, no. 5 (2021): 1280. http://dx.doi.org/10.3390/molecules26051280.

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Multidrug resistance (MDR) remains a major problem in cancer therapy and is characterized by the overexpression of p-glycoprotein (P-gp) efflux pump, upregulation of anti-apoptotic proteins or downregulation of pro-apoptotic proteins. In this study, an Apolipoprotein A1 (ApoA1)-modified cationic liposome containing a synthetic cationic lipid and cholesterol was developed for the delivery of a small-molecule chemotherapeutic drug, doxorubicin (Dox) to treat MDR tumor. The liposome-modified by ApoA1 was found to promote drug uptake and elicit better therapeutic effects than free Dox and liposome

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Kundawala, Aliasgar J., Khushbu S. Chauhan, Harsha V. Patel, and Swati K. Kurtkoti. "Inhalable Spray Dried Pro-Liposome Powder Containing Budesonide for Pulmonary Delivery." International Journal of Pharmaceutical Sciences and Nanotechnology 14, no. 4 (2021): 5538–48. http://dx.doi.org/10.37285/ijpsn.2021.14.4.3.

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Budesonide is an anti-asthmatic agent which is used to control the symptoms of asthma like bronchospasm, oedema. Drug delivered to lung through inhalation will provide systemic and local drug delivery at lower dose in chronic and acute diseases. Dry powder inhalers are the best choice for targeting the anti-asthmatic drugs through pulmonary route. The objective of the present study is to prepare inhalable lipid coated budesonide microparticles by spray drying method so effective delivery of budesonide to the lungs can be achieved. The microparticles in the form of dry powder were obtained by e

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Gaspar, Maria Manuela, Oliviero Gobbo, and Carsten Ehrhardt. "Generation of liposome aerosols with the Aeroneb Pro and the AeroProbe nebulizers." Journal of Liposome Research 20, no. 1 (2010): 55–61. http://dx.doi.org/10.3109/08982100903085150.

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Gaspar, Maria Manuela, Oliviero Gobbo, and Carsten Ehrhardt. "Generation of liposome aerosols with the Aeroneb Pro and the AeroProbe nebulizers." Journal of Liposome Research 00, no. 00 (2009): 090706063146008–7. http://dx.doi.org/10.1080/08982100903085150.

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Ayush, S. Jaiswal*1 Rekha Gaukande2 Gajanan Sanap3. "A Review On Liposomes As Drug Delivery System." International Journal in Pharmaceutical Sciences 1, no. 12 (2023): 926–36. https://doi.org/10.5281/zenodo.10442217.

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Liposomes are composed of phospholipids and lipids, forming spherical or multilayered vesicles with a lipid bilayer structure in aqueous solutions due to self-assembly of diacyl chain phospholipids. The number of bilayers and the size of vesicles influence the amount of drug encapsulation in liposomes, a crucial factor in determining their circulation half-life. This method involves coating a medication and a lipid onto a soluble carrier to create a pro-liposome, which is free-flowing and granular. When hydrated, it forms an isotonic liposomal solution. This pro-liposome approach serves as a m

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Jing, De-Bao, Su-Ping Yu, Xiao-Hua Zhuang, Qing Cai, and Kai Wang. "Preparation of Baicalein Long-Circulating Liposome and Its Effect on Bone Implantation in Diabetic Rats." Journal of Biomedical Nanotechnology 19, no. 3 (2023): 383–96. http://dx.doi.org/10.1166/jbn.2023.3544.

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Gradual increase in blood glucose is the major characteristics of a metabolic disease like diabetes. Inflammatory microenvironment and diabetes induced osteoporosis seriously affect prognosis of patients that undergo bone implantation. Baicalein is a natural flavonoid compound with hypoglycemic, anti-inflammatory and other pharmacological functions. Clinically, the application of baicalein is hampered by inadequate solubility, low bioavailability and other shortcomings. In this report, we designed a long-circulating liposome for potential delivery of baicalein. The best formula for long-circul

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Kim, Joan, and Ho Sueb Song. "Bee Venom Within Liposomes Synergistically Inhibit Atopic Dermatitis in Mice." Journal of Acupuncture Research 39, no. 1 (2022): 40–48. http://dx.doi.org/10.13045/jar.2021.00318.

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Background: This study was performed to determine the effects of liposome-encapsulated bee venom (BV) treatment of inflammatory factors in atopic dermatitis (AD) compared with BV treatment.Methods: AD was induced by phthalic anhydride in mice and the effects of BV liposomes were measured. Using Leica Application Suite, thickened epidermis and dermis were measured after BV liposome treatment (0.05 and 0.1 μg/mL). The number of stained mast cells and the concentration of immunoglobulin (Ig)E were measured. Serum IgE concentration was analyzed using an enzyme-linked immunosorbent assay. The serum

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Alves, Ana, Marta Correia-da-Silva, Claúdia Nunes, et al. "Discovery of a New Xanthone against Glioma: Synthesis and Development of (Pro)liposome Formulations." Molecules 24, no. 3 (2019): 409. http://dx.doi.org/10.3390/molecules24030409.

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Following our previous work on the antitumor activity of acetylated flavonosides, a new acetylated xanthonoside, 3,6-bis(2,3,4,6-tetra-O-acetyl-β-glucopyranosyl)xanthone (2), was synthesized and discovered as a potent inhibitor of tumor cell growth. The synthesis involved the glycosylation of 3,6-di-hydroxyxanthone (1) with acetobromo-α-d-glucose. Glycosylation with silver carbonate decreased the amount of glucose donor needed, comparative to the biphasic glycosylation. Xanthone 2 showed a potent anti-growth activity, with GI50 < 1 μM, in human cell lines of breast, lung, and glioblastoma c

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Sonkawade, Swati D., Shirley Xu, Minhyung Kim, et al. "Phospholipid Encapsulation of an Anti-Fibrotic Endopeptide to Enhance Cellular Uptake and Myocardial Retention." Cells 12, no. 12 (2023): 1589. http://dx.doi.org/10.3390/cells12121589.

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Background: Cardioprotective effects of N-acetyl-ser-asp-lys-pro (Ac-SDKP) have been reported in preclinical models of myocardial remodeling. However, the rapid degradation of this endogenous peptide in vivo limits its clinical use. Method: To prolong its bioavailability, Ac-SDKP was encapsulated by phosphocholine lipid bilayers (liposomes) similar to mammalian cell membranes. The physical properties of the liposome structures were assessed by dynamic light scattering and scanning electron microscopy. The uptake of Ac-SDKP by RAW 264.7 macrophages and human and murine primary cardiac fibroblas

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Amalia, Eri, Iyan Sopyan, Norisca Aliza Putriana, and Sriwidodo Sriwidodo. "Preparation and molecular interaction of organic solvent-free piperine pro-liposome from soy lecithin." Heliyon 9, no. 6 (2023): e16674. http://dx.doi.org/10.1016/j.heliyon.2023.e16674.

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Pan, Junliang, Tongyao Liu, Ji-Yun Kim, et al. "Enhanced Efficacy of Recombinant Factor VIII in Non-Covalent Complex with PEGylated Liposome in Hemophilia A Mice." Blood 110, no. 11 (2007): 3149. http://dx.doi.org/10.1182/blood.v110.11.3149.3149.

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Abstract BAY 79-4980, a non-covalent complex of rFVIII (Kogenate® FS) reconstituted in PEGylated Liposome (PEG-Lip) diluent, was reported to double the bleed-free days in severe hemophilia A patients from 7 to 13 days (35 IU/kg) and 6 to 11 days (25 IU/kg), as compared to respectively corresponding doses of rFVIII1. However, in a more recent phase I trial, the FVIII pharmacokinetics (PK) in plasma was virtually identical in patients who received either rFVIII or BAY 79-4980. To understand the mechanism of action of BAY 79-4980, we compared the pharmacological efficacy and PK of BAY 79-4980 to

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Liu, Chang, Xiaoqing Wang, Wei Xu, et al. "Study on the Pharmacological Efficacy and Mechanism of Dual-Target Liposome Complex AD808 Against Alzheimer’s Disease." Pharmaceuticals 18, no. 7 (2025): 977. https://doi.org/10.3390/ph18070977.

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Background/Objectives: To study the efficacy and pharmacological mechanism of the dual-target liposome complex AD808 in the treatment of Alzheimer’s disease. Methods: Using APP/PS1 mouse models, the therapeutic efficacy and pharmacological mechanism of AD808 on Alzheimer’s disease were studied through water maze tests, brain tissue staining, immunofluorescence, and ELISA for inflammatory and neurotrophic factors. Results: AD808 exhibited significant pharmacodynamic effects in improving behavioral and cognitive abilities (70% reduction in escape latency) and repairing damaged nerve cells (90% r

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White, Maria, Jason Debley, and Dennis Lindell. "Development of a vaccine to attenuate viral exacerbation of asthma (P4276)." Journal of Immunology 190, no. 1_Supplement (2013): 123.1. http://dx.doi.org/10.4049/jimmunol.190.supp.123.1.

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Abstract Viral exacerbation of asthma exacerbation is a major cause of emergency department visits and hospitalization. Thus, vaccination against causative viruses would be an effective method for the attenuation of viral exacerbation for asthmatics. Because live/attenuated vaccines are not safe for asthmatics, inactivated viral vaccines need to be developed. We hypothesize that the innate immune response produces pro-inflammatory signals that determine the outcome of the adaptive immune response. We are evaluating the potential of an intranasal inactivated respiratory syncytial virus vaccine

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Lee, Hak-Il, Won-Kyu Rhim, Eun-Young Kang, Bogyu Choi, Jun-Hyeok Kim, and Dong-Keun Han. "A Multilayer Functionalized Drug-Eluting Balloon for Treatment of Coronary Artery Disease." Pharmaceutics 13, no. 5 (2021): 614. http://dx.doi.org/10.3390/pharmaceutics13050614.

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Drug-eluting balloons (DEBs) have been mostly exploited as an interventional remedy for treating atherosclerosis instead of cardiovascular stents. However, the therapeutic efficacy of DEB is limited due to their low drug delivery capability to the disease site. The aim of our study was to load drugs onto a balloon catheter with preventing drug loss during transition time and maximizing drug transfer from the surface of DEBs to the cardiovascular wall. For this, a multilayer-coated balloon catheter, composed of PVP/Drug-loaded liposome/PVP, was suggested. The hydrophilic property of 1st layer,

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Rogers, M. S., R. P. Patel, B. J. Reeder, P. Sarti, M. T. Wilson, and A. I. Alayash. "Pro-oxidant effects of cross-linked haemoglobins explored using liposome and cytochrome c oxidase vesicle model membranes." Biochemical Journal 310, no. 3 (1995): 827–33. http://dx.doi.org/10.1042/bj3100827.

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The therapeutic use of cell-free haemoglobin as a blood substitute has been hampered by toxicological effects. A model asolectin (phosphatidylcholine/phosphatidylethanolamine) liposome system was utilized to study the pro-oxidant efficiency of several chemically modified haemoglobins on biological membranes. Lipid peroxidation, resulting from the interactions between haemoglobin and liposomes, was measured by conjugated diene formation and the maximal rates of oxygen uptake. Spectral changes gave insight into the occurrence of the ferryl iron species. The residual reactivity of oxidatively dam

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Hong, Chi Rac, Eun Ha Lee, Young Hoon Jung, et al. "Development and Characterization of Inula britannica Extract-Loaded Liposomes: Potential as Anti-Inflammatory Functional Food Ingredients." Antioxidants 12, no. 8 (2023): 1636. http://dx.doi.org/10.3390/antiox12081636.

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We investigated the potential of Inula britannica extract encapsulated in liposomes as a functional food ingredient with enhanced bioavailability and stability. Inula britannica, known for its anti-inflammatory properties and various health benefits, was encapsulated using a liposome mass production manufacturing method, and the physical properties of liposomes were evaluated. The liposomes exhibited improved anti-inflammatory effects in lipopolysaccharide-activated RAW 264.7 macrophages, suppressing the production of pro-inflammatory mediators such as nitric oxide and prostaglandin E2 and dow

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Le, Nguyen Bui Thao, Anh Thi Tram Tu, Dandan Zhao, et al. "Influence of the Charge Ratio of Guanine-Quadruplex Structure-Based CpG Oligodeoxynucleotides and Cationic DOTAP Liposomes on Cytokine Induction Profiles." Biomolecules 13, no. 11 (2023): 1639. http://dx.doi.org/10.3390/biom13111639.

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Cationic liposomes, specifically 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) liposomes, serve as successful carriers for guanine-quadruplex (G4) structure-based cytosine-guanine oligodeoxynucleotides (CpG ODNs). The combined benefits of CpG ODNs forming a G4 structure and a non-viral vector carrier endow the ensuing complex with promising adjuvant properties. Although G4-CpG ODN-DOTAP complexes show a higher immunostimulatory effect than naked G4-CpG ODNs, the effects of the complex composition, especially charge ratios, on the production of the pro-inflammatory cytokines interleukin (IL)

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De Miguel, Diego, Ana Gallego-Lleyda, Miguel Martinez-Ara, Javier Plou, Alberto Anel, and Luis Martinez-Lostao. "Double-Edged Lipid Nanoparticles Combining Liposome-Bound TRAIL and Encapsulated Doxorubicin Showing an Extraordinary Synergistic Pro-Apoptotic Potential." Cancers 11, no. 12 (2019): 1948. http://dx.doi.org/10.3390/cancers11121948.

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Although TRAIL (TNF-related apoptosis-inducing ligand, also known as Apo2L) was described as capable of inducing apoptosis in transformed cells while sparing normal cells, limited results obtained in clinical trials has limited its use as an anti-tumor agent. Consequently, novel TRAIL formulations with enhanced bioactivity are necessary for overcoming resistance to conventional soluble TRAIL (sTRAIL) exhibited by many primary tumors. Our group has generated artificial liposomes with sTRAIL anchored on their surface (large unilamellar vesicle (LUV)-TRAIL), which have shown a greater cytotoxic a

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Zhang, Tao, Mi Su, Xiaoxiao Jiang, et al. "Transepithelial Transport Route and Liposome Encapsulation of Milk-Derived ACE-Inhibitory Peptide Arg-Leu-Ser-Phe-Asn-Pro." Journal of Agricultural and Food Chemistry 67, no. 19 (2019): 5544–51. http://dx.doi.org/10.1021/acs.jafc.9b00397.

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Hirose, Masanori, Takaaki Ishigami, Keishi Suga та Hiroshi Umakoshi. "Liposome Membrane as a Platform for the l-Pro-Catalyzed Michael Addition of trans-β-Nitrostyrene and Acetone". Langmuir 31, № 47 (2015): 12968–74. http://dx.doi.org/10.1021/acs.langmuir.5b03439.

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Kuwana, Tomomi, Louise E. King, Katia Cosentino, et al. "Mitochondrial residence of the apoptosis inducer BAX is more important than BAX oligomerization in promoting membrane permeabilization." Journal of Biological Chemistry 295, no. 6 (2020): 1623–36. http://dx.doi.org/10.1074/jbc.ra119.011635.

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Permeabilization of the mitochondrial outer membrane is a key step in the intrinsic apoptosis pathway, triggered by the release of mitochondrial intermembrane space proteins into the cytoplasm. The BCL-2–associated X apoptosis regulator (BAX) protein critically contributes to this process by forming pores in the mitochondrial outer membrane. However, the relative roles of the mitochondrial residence of BAX and its oligomerization in promoting membrane permeabilization are unclear. To this end, using both cell-free and cellular experimental systems, including membrane permeabilization, size-exc

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Li, Zhe, Jinhua Liu, Yingqun Zhu, and Qian Cai. "Regulatory mechanism of lncRNA miR143HG in miR-504 and its effect on proliferation and apoptosis of non-small cell lung cancer cells." Tropical Journal of Pharmaceutical Research 23, no. 8 (2024): 1231–37. http://dx.doi.org/10.4314/tjpr.v23i8.1.

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Purpose: To investigate the expression and functional role of miR143HG in non-small cell lung cancer (NSCLC), and its effect on human lung adenocarcinoma cell behavior. Methods: Differential expression of miR143HG between NSCLC tissues and healthy counterparts was identified through bioinformatic analysis. Subsequently, this expression difference in A549 and BEAS2B cells was validated using quantitative polymerase chain reaction (qPCR). Overexpression of miR143HG in A549 cells was achieved through liposome-mediated transfection, while cell proliferation as well as apoptosis levels were assesse

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Soler-Agesta, Ruth, Patricia Guerrero-Ochoa, Joaquín Marco-Brualla, et al. "Conjugation of the 9-kDa Isoform of Granulysin with Liposomes Potentiates Its Cytotoxicity." International Journal of Molecular Sciences 23, no. 15 (2022): 8705. http://dx.doi.org/10.3390/ijms23158705.

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Nine kDa granulysin (GRNLY) is a human cytolytic protein secreted by cytotoxic T lymphocytes (CTL) and NK cells of the immune system whose demonstrated physiological function is the elimination of bacteria and parasites. In previous studies by our group, the anti-tumor capacity of recombinant granulysin was demonstrated, both in vitro and in vivo. In the present work, we developed lipid nanoparticles whose surfaces can bind recombinant granulysin through the formation of a complex of coordination between the histidine tail of the protein and Ni2+ provided by a chelating lipid in the liposome c

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Dinh, Thuy Duong, Yuriko Higuchi, Shigeru Kawakami, Fumiyoshi Yamashita та Mitsuru Hashida. "Evaluation of Osteoclastogenesis via NFκB Decoy/mannosylated Cationic Liposome-Mediated Inhibition of Pro-inflammatory Cytokine Production from Primary Cultured Macrophages". Pharmaceutical Research 28, № 4 (2011): 742–51. http://dx.doi.org/10.1007/s11095-011-0366-0.

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Jhun, Jooyeon, Jeonghyeon Moon, Jaeyoon Ryu, et al. "Liposome/gold hybrid nanoparticle encoded with CoQ10 (LGNP-CoQ10) suppressed rheumatoid arthritis via STAT3/Th17 targeting." PLOS ONE 15, no. 11 (2020): e0241080. http://dx.doi.org/10.1371/journal.pone.0241080.

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Coenzyme Q10 (CoQ10), also known as ubiquinone, is a fat-soluble antioxidant. Although CoQ10 has not been approved as medication by the Food and Drug Administration, it is widely used in dietary supplements. Some studies have shown that CoQ10 has anti-inflammatory effects on various autoimmune disorders. In this study, we investigated the anti-inflammatory effects of liposome/gold hybrid nanoparticles encoded with CoQ10 (LGNP-CoQ10). Both CoQ10 and LGNP-CoQ10 were administered orally to mice with collagen-induced arthritis (CIA) for 10 weeks. The inflammation pathology of joint tissues of CIA

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Matviykiv, Sofiya, Marzia Buscema, Gabriela Gerganova, et al. "Immunocompatibility of Rad-PC-Rad liposomes in vitro, based on human complement activation and cytokine release." Precision Nanomedicine 1, no. 1 (2018): 43–62. http://dx.doi.org/10.29016/180419.2.

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Liposomal drug delivery systems can protect pharmaceutical substances and control their release. Systemic administration of liposomes, however, often activate the innate immune system, resulting in hypersensitivity reactions. These pseudo-allergic reactions can be interpreted as activating the complement system. Complement activation destroys and eliminates foreign substances, either directly through opsonization and the formation of the membrane attack complex (MAC), or by activating leukocytes and initiating inflammatory responses via mediators, such as cytokines. In this study, we investiga

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Steers, Nicholas J., Kristina K. Peachman, Sasha McClain, Carl R. Alving, and Mangala Rao. "Liposome-encapsulated HIV-1 Gag p24 containing lipid A induces effector CD4+ T-cells, memory CD8+ T-cells, and pro-inflammatory cytokines." Vaccine 27, no. 49 (2009): 6939–49. http://dx.doi.org/10.1016/j.vaccine.2009.08.105.

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Chaturvedi, Shashank, Anurag Verma, and Vikas Anand Saharan. "Lipid Drug Carriers for Cancer Therapeutics: An Insight into Lymphatic Targeting, P-gp, CYP3A4 Modulation and Bioavailability Enhancement." Advanced Pharmaceutical Bulletin 10, no. 4 (2020): 524–41. http://dx.doi.org/10.34172/apb.2020.064.

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In the treatment of cancer, chemotherapy plays an important role though the efficacy of anticancer drug administered orally is limited, due to their poor solubility in physiological medium, inability to cross biological membrane, high Para-glycoprotein (P-gp) mediated drug efflux, and pre-systemic metabolism. These all factors cumulatively reduce drug exposure at the target site leading to multidrug resistance (MDR). Lipid based carriers systems has been explored to overcome solubility and permeability related issues of anti-cancer drugs. The lipid based formulations have also been reported to

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STRAGHAN, ESTHER, GEETA SHARMA, PETER GOLDFARB, and ALAN WISEMAN. "IDENTIFICATION OF PRO-OXIDANT OR ANTIOXIDANT CHARACTERISTICS OF PROTEINS AND ENZYMES IN MEMBRANES; USE OF LIPOSOME-ENTRAPPED PROTEINS AND OTHER THIOL-CONTAINING COMPOUNDS." Biochemical Society Transactions 24, no. 3 (1996): 375S. http://dx.doi.org/10.1042/bst024375s.

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Navarro-Partida, Jose, Juan Carlos Altamirano-Vallejo, Luis Abraham Aceves Franco, et al. "Topical Triamcinolone Acetonide-Loaded Liposome Formulation Used as an Adjuvant to Intravitreal Ranibizumab Therapy for Neovascular Age-Related Macular Degeneration." Pharmaceutics 13, no. 9 (2021): 1491. http://dx.doi.org/10.3390/pharmaceutics13091491.

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Novel strategies have been developed to reduce or avoid intravitreal injections (IVTs) of the antiangiogenic (ranibizumab (RBZ)) and anti-inflammatory (triamcinolone acetonide (TA)) agents used to treat vitreoretinal diseases. One of the strategies includes liposomes. This study evaluated the safety and efficacy of a topical triamcinolone-loaded liposome formulation (TALF) as an adjuvant to intravitreal RBZ therapy in treatment- naïve patients with neovascular age-related macular degeneration (nAMD). Subjects were randomly assigned to the RBZ-TALF or the RBZ-pro re nata (RBZ-PRN) groups. Patie

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Janas, Teresa, Pawel Janas, Karolina Sapoń, and Tadeusz Janas. "Binding of RNA Aptamers to Membrane Lipid Rafts: Implications for Exosomal miRNAs Transfer from Cancer to Immune Cells." International Journal of Molecular Sciences 21, no. 22 (2020): 8503. http://dx.doi.org/10.3390/ijms21228503.

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Intraluminal vesicles (ILVs) are released into the extracellular space as exosomes after the fusion of multivesicular bodies (MVBs) with the plasma membrane. miRNAs are delivered to the raft-like region of MVB by RNA-binding proteins (RBPs). RNA loading into exosomes can be either through direct interaction between RNA and the raft-like region of the MVB membrane, or through interaction between an RBP–RNA complex with this raft-like region. Selection of RNA aptamers that bind to lipid raft region of liposomal membranes was performed using the selection-amplification (SELEX) method. The pool of

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Yuki, Yoshikazu, Tomonori Nochi, Mio Mejima, et al. "A novel nanosize protein-carrier for the development of adjuvant- free nasal vaccine (39.33)." Journal of Immunology 182, no. 1_Supplement (2009): 39.33. http://dx.doi.org/10.4049/jimmunol.182.supp.39.33.

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Abstract Most of inactivated or subunit type vaccines are poor immunogens to both systemic and mucosal immune compartments when given mucosally without mucosal adjuvant. We developed an effective intracellular vaccine delivery system with self-assembled nanosize cationic hyrogels (nanogel), which composed of a polysaccharide with ethylendiamine group of cholesteryl group-bearing pullulan. When hold protein antigen in a segregated nanomatrix, the nanogel acts as artificial chaperones, which protect against the aggregation of denature proteins and assist in the refolding of protein after release

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Jacobsen, Rebecca, Allison R. Pettit, Liza J. Raggatt, et al. "Mobilizing Doses Of G-CSF Stop Medullary Erythropoiesis By Depleting F4/80+ VCAM1+ ER-HR3+ CD169+ Erythroid-Island Macrophages." Blood 122, no. 21 (2013): 309. http://dx.doi.org/10.1182/blood.v122.21.309.309.

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Abstract G-CSF mobilizes hematopoietic stem cells (HSCs) from the bone marrow (BM) into the blood by suppressing a subset of HSC niche supportive macrophages. As macrophages are the central component of erythropoietic islands in BM, spleen and liver, we examined the effect of G-CSF on erythropoiesis in C57BL/6 mice. Mobilizing doses of G-CSF caused a marked whitening of the BM, a 15-fold decrease in the number of phenotypic erythroblasts, a 1.5-fold decrease in polychromatic and orthochromatic erythroblasts, and a 4.5-fold reduction in reticulocytes in the BM. Conversely, more immature pro-ery

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Chattopadhyay, Saborni, Yu-Pei Liao, Xiang Wang, and André E. Nel. "Use of Stromal Intervention and Exogenous Neoantigen Vaccination to Boost Pancreatic Cancer Chemo-Immunotherapy by Nanocarriers." Bioengineering 10, no. 10 (2023): 1205. http://dx.doi.org/10.3390/bioengineering10101205.

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Despite the formidable treatment challenges of pancreatic ductal adenocarcinoma (PDAC), considerable progress has been made in improving drug delivery via pioneering nanocarriers. These innovations are geared towards overcoming the obstacles presented by dysplastic stroma and fostering anti-PDAC immune reactions. We are currently conducting research aimed at enhancing chemotherapy to stimulate anti-tumor immunity by inducing immunogenic cell death (ICD). This is accomplished using lipid bilayer-coated nanocarriers, which enable the attainment of synergistic results. Noteworthy examples include

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Koh, Eun-Young, Keun-Sik Kim, Hee-Bin Park, Jong-Seok Kim, and Pyung-Hwan Kim. "Active Targeting of Versatile Nanocomplex Using the Novel Biomarker of Breast Cancer Stem Cells." International Journal of Molecular Sciences 24, no. 1 (2022): 685. http://dx.doi.org/10.3390/ijms24010685.

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Breast cancer in women is one of the most common life-threatening malignancies. Despite of the development for the improved treatment, there are still many limitations to overcome. Among them, cancer stem cells (CSCs) are well known for tumor formation, development, cellular heterogeneity, and cancer recurrence. Therefore, to completely cure breast cancer, treatment of both cancer and CSC is required. To selectively target CSCs, we generated a liposome-based smart nano complex using CEACAM 6 (CD66c) antibody (Ab), a novel cell-surface biomarker of breast-derived CSCs (BCSCs) discovered in our

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Facoetti, A., L. Massimino, S. Cagliani, et al. "P101 Investigating the role of gut eukaryotic virome in contributing to colorectal cancer carcinogenesis." Journal of Crohn's and Colitis 18, Supplement_1 (2024): i382. http://dx.doi.org/10.1093/ecco-jcc/jjad212.0231.

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Abstract Background Eukaryotic-targeting viruses have recently attracted interest in gastrointestinal diseases such as ulcerative colitis (UC) and colorectal cancer (CRC). UC and CRC share several factors influencing their etiogenesis, including intestinal dysbiosis. Our group has recently published a work pinpointing a gut virome-associated Orthohepadnaviridae protein, the Hepatitis B protein X (HBx) to correlate with UC pathogenesis and promote intestinal inflammation in mice by disrupting the epithelial barrier and shaping the gut mucosal immune environment, independently of the microbiota.

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Falconer, James R., Darren Svirskis, Ali A. Adil, and Zimei Wu. "Supercritical Fluid Technologies to Fabricate Proliposomes." Journal of Pharmacy & Pharmaceutical Sciences 18, no. 5 (2015): 747. http://dx.doi.org/10.18433/j3qp58.

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Proliposomes are stable drug carrier systems designed to form liposomes upon addition of an aqueous phase. In this review, current trends in the use of supercritical fluid (SCF) technologies to prepare proliposomes are discussed. SCF methods are used in pharmaceutical research and industry to address limitations associated with conventional methods of pro/liposome fabrication. The SCF solvent methods of proliposome preparation are eco-friendly (known as green technology) and, along with the SCF anti-solvent methods, could be advantageous over conventional methods; enabling better design of par

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Slika, Layal, and Digambara Patra. "Traditional Uses, Therapeutic Effects and Recent Advances of Curcumin: A Mini-Review." Mini-Reviews in Medicinal Chemistry 20, no. 12 (2020): 1072–82. http://dx.doi.org/10.2174/1389557520666200414161316.

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Studies regarding the uses and biological benefits curcumin have long been paid worldwide attention. Curcumin is a polyphenol found in the turmeric spice, which is derived from the rhizomes of Curcuma longa. Curcumin is a major constituent of the traditional Indian holistic system, Ayurveda, and it is well-known in treating diverse ailments. The aim of this study is to conduct an overview that introduces the traditional uses and therapeutic effects of this valuable phytochemical with more focus on the antitumor results. This review was conducted based on published articles on PubMed, Medline,

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Agrawal, Surendra S., Vrinda Baliga, and Vaishali Y. Londhe. "Liposomal Formulations: A Recent Update." Pharmaceutics 17, no. 1 (2024): 36. https://doi.org/10.3390/pharmaceutics17010036.

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Liposome-based drug delivery technologies have showed potential in enhancing medication safety and efficacy. Innovative drug loading and release mechanisms highlighted in this review of next-generation liposomal formulations. Due to poor drug release kinetics and loading capacity, conventional liposomes have limited clinical use. Scientists have developed new liposomal carrier medication release control and encapsulation methods to address these limits. Drug encapsulation can be optimized by creating lipid compositions that match a drug’s charge and hydrophobicity. By selecting lipids and addi

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Kesharwani, Prashant, Shadab Md, Nabil A. Alhakamy, Khaled M. Hosny, and Anzarul Haque. "QbD Enabled Azacitidine Loaded Liposomal Nanoformulation and Its In Vitro Evaluation." Polymers 13, no. 2 (2021): 250. http://dx.doi.org/10.3390/polym13020250.

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Azacitidine (AZA), an inhibitor of DNA methyltransferase, is a commonly recognized drug used in clinical treatment for myelodysplastic syndrome and breast cancer. Due to higher aqueous solubility and negative log P of AZA causes poor cancer cell permeation and controlled release. The objective of the present study was to formulate and optimize AZA-loaded liposome (AZA-LIPO) for breast cancer chemotherapy by using Box Behnken design (BBD) and in vitro evaluation using MCF-7 cells. AZA-LIPO were prepared using a thin film hydration technique and characterization study was performed by using FTIR

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Islam, Md Rakibul, Jalpa Patel, Patricia Ines Back, et al. "Pegylated Liposomal Alendronate Biodistribution, Immune Modulation, and Tumor Growth Inhibition in a Murine Melanoma Model." Biomolecules 13, no. 9 (2023): 1309. http://dx.doi.org/10.3390/biom13091309.

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While tumor-associated macrophages (TAM) have pro-tumoral activity, the ablation of macrophages in cancer may be undesirable since they also have anti-tumoral functions, including T cell priming and activation against tumor antigens. Alendronate is a potent amino-bisphosphonate that modulates the function of macrophages in vitro, with potential as an immunotherapy if its low systemic bioavailability can be addressed. We repurposed alendronate in a non-leaky and long-circulating liposomal carrier similar to that of the clinically approved pegylated liposomal doxorubicin to facilitate rapid clin

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Chiabotto, Giulia, Armina Semnani, Elena Ceccotti, and Stefania Bruno. "Extracellular vesicles: emerging therapeutic agents for liver fibrosis." Extracellular Vesicles and Circulating Nucleic Acids 6, no. 2 (2025): 216–44. https://doi.org/10.20517/evcna.2025.08.

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Liver fibrosis is a progressive condition characterized by excessive scar tissue buildup, leading to impaired liver function and potentially cirrhosis. Despite advancements in treatment strategies, effective anti-fibrotic therapies remain an urgent unmet need. Recent research has identified extracellular vesicles (EVs) as promising therapeutic agents due to their ability to mediate intercellular communication and regulate key fibrotic pathways. This review aims to provide a comprehensive overview of the therapeutic potential of EVs in different in vitro and in vivo models of hepatic fibrosis,

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Nayak, Lalitha V., Stephanie Lapping, Andrei Maiseyeu, Alvin H. Schmaier, and Mukesh Jain. "Neutrophil KLF2 Regulates Arterial and Venous Thrombosis." Blood 132, Supplement 1 (2018): 75. http://dx.doi.org/10.1182/blood-2018-99-113719.

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Abstract Experimental, clinical and pathological studies support an important link between inflammation and thrombosis. Although accumulating evidence suggests that cells of the innate immune system contribute to the thrombotic process, the identity of nodal molecular determinants operative in immune cells remains poorly understood. Our previous work in mice bearing global deletion of the transcription factor KLF2 identifiedthis factor as a critical mediator of thrombosis). Here, using cell-specific KLF2 deleted murine models (endothelial, platelet, and myeloid- deleted KLF2) we identify myelo

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Zanieri, Francesca, Ana Levi, David Montefusco, et al. "Exogenous Liposomal Ceramide-C6 Ameliorates Lipidomic Profile, Energy Homeostasis, and Anti-Oxidant Systems in NASH." Cells 9, no. 5 (2020): 1237. http://dx.doi.org/10.3390/cells9051237.

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In non-alcoholic steatohepatitis (NASH), many lines of investigation have reported a dysregulation in lipid homeostasis, leading to intrahepatic lipid accumulation. Recently, the role of dysfunctional sphingolipid metabolism has also been proposed. Human and animal models of NASH have been associated with elevated levels of long chain ceramides and pro-apoptotic sphingolipid metabolites, implicated in regulating fatty acid oxidation and inflammation. Importantly, inhibition of de novo ceramide biosynthesis or knock-down of ceramide synthases reverse some of the pathology of NASH. In contrast,

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