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Thèses sur le sujet « Proteinaceo »

Auteur : Grafiati

Publié le 9 mars 2023

Mis à jour le 31 juillet 2025

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1

ZEYNALI, AMIRBAHADOR. "Two-photon assisted direct laser writing of proteinaceous microarchitectures containing plasmonic nanoparticles; characterization and optimization." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2021. http://hdl.handle.net/10281/304319.

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Le nanoparticelle metalliche, grazie alle loro affascinanti proprietà ottiche ed elettrochimiche, attirano l'attenzione di diverse discipline scientifiche e di ricerca ingegneristica. Tra queste proprietà, l'effetto fototermico indotto dalle risonanze plasmoniche, è una caratteristica notevole ed esclusiva delle nanoparticelle di metalli nobili che, ad oggi, vengono già sfruttate per vari scopi, sia per ricerca che, soprattutto, per applicazioni biomediche. Il fenomeno della risonanza plasmonica superficiale, caratterizzato da bande ben definite, fornisce a queste nanoparticelle una notevole l

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2

Turk, Boris. "Papain-like cysteine proteinases : regulation by proteinase inhibitors and pH /." Uppsala : Swedish Univ. of Agricultural Sciences (Sveriges lantbruksuniv.), 1996. http://epsilon.slu.se/avh/1996/91-576-5227-9.gif.

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3

Zhang, Xiaorong. "The roles of proteinases and proteinase inhibitors in plant-nematode interactions." Diss., Virginia Tech, 1994. http://hdl.handle.net/10919/37260.

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4

Bridges, Sylvia Shadinger. "Design, synthesis, and evaluation of cysteine protease inhibitors." Diss., Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/29738.

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Proteases are enzymes that cleave protein amide bonds. Proteases are involved in a myriad of biological processes and are considered good targets for drug design. The proteases described herein are cysteine proteases, which utilize a cysteine residue thiol to attack the amide carbonyl, leading to amide bond cleavage. Irreversible inhibitors of cysteine proteases react with the active site cysteine, forming a covalent bond and rendering the enzyme inactive. The first project involved the design and synthesis of aza-peptide epoxide inhibitors for calpain, a clan CA, ubiquitous, calcium-activa

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5

Souza, Thais Paula de. "Efeito dos inibidores de proteinase de soja no padrão de expressão de proteinases de Spodoptera frugiperda." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/11/11137/tde-05112013-150120/.

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Dentre as substâncias químicas secretadas pelas plantas, contra os insetos herbívoros, os inibidores de peptidases são de grande interesse. A atenção dada a esses inibidores deve-se ao fato, de eles serem uma boa alternativa no controle de insetos praga, uma vez que não causam danos ao meio ambiente. Contudo, muitas espécies de insetos são capazes de escapar dos efeitos negativos dos inibidores de peptidases das plantas, via diferentes mecanismos adaptativos. Devido a esse fato, é importante compreender os mecanismos desenvolvidos pelos insetos para burlar os efeitos dos inibidores de peptidas

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6

Nadalini, Larissa Cristina Deppmann. "Caracterização do mecanismo adaptativo de Spodoptera frugiperda aos inibidores de proteinase de plantas." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/11/11137/tde-07022008-151221/.

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A existência de uma família gênica diversa de serino proteinases em Lepidóptera sugere que essas proteinases desempenham um papel importante na adaptação desses insetos à presença de inibidores de proteinases vegetais. Essas enzimas têm se revelado estarem envolvidas no processo digestivo de larvas de insetos. Larvas de Spodoptera frugiperda foram alimentadas com uma dieta suplementada com inibidor de proteinase de soja (IPS) e a expressão gênica de proteinases intestinais foi avaliada através de PCR em tempo real. Análises de transcrição anteriores mostraram a existência de dois grupos de ser

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7

Estrada, Sergio. "Cystatin A, a mammalian cysteine proteinase inhibitor : mechanism of inhibition of target proteinases by recombinant cystatin A variants /." Uppsala : Swedish Univ. of Agricultural Sciences (Sveriges lantbruksuniv.), 1998. http://epsilon.slu.se/avh/1998/91-576-5448-4.gif.

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8

Souza, Diego Pereira de. "ProteÃnas inibidoras de fitopatÃgenos em fluidos laticÃferos: atividade e mecanismo de aÃÃo." Universidade Federal do CearÃ, 2010. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=7887.

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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>Um relevante nÃmero de espÃcies vegetais Ã descrito como plantas produtoras de um fluido leitoso comumente denominado de lÃtex. Nestas espÃcies, o lÃtex Ã sintetizado e armazenado sob pressÃo em um sistema de canais formados por cÃlulas altamente especializadas denominadas de laticÃferas, em cujos citoplasmas estÃo presentes todas as estruturas eucariontes em meio Ã Ãgua, borracha e inÃmeras molÃculas, muitas das quais especÃficas deste conteÃdo. Muitos estudos tÃm sugerido que molÃculas produzidas nestes fluidos participam da defe

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9

Macgregor, James Mylne. "Alimentary tract proteinases of the Southern corn rootworm (Diabrotica undecimpunctata howardi) and the potential of potato Kunitz proteinase inhibitors for larval control." Thesis, Durham University, 2001. http://etheses.dur.ac.uk/3808/.

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Proteolytic digestion by larval Diabrotica undecimpunctata howardi (Barber) (D.undecimpunctata) has been investigated with the aim of producing transgenic plants possessing enhanced resistance to this economically important crop pest. Biochemical characterisation in vitro by pH dependent hydrolysis and inhibition assays incorporating E-64, pepstatin A and soybean Kunitz trypsin inhibitor showed the majority of hydrolytic activity occurs at pH 5.5 and is performed by cysteine and aspartic endopeptidases. Cysteine and aspartic proteinase encoding clones were isolated from a larval alimentary tra

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10

Mistry, Rohit. "Development of a sheep model to investigate the role of neutrophil proteinases and their endogenous inhibitors in acute lung injury : a novel proteinase inhibitor." Thesis, Imperial College London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308934.

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11

Silva, Walciane da. "Estudo da ação do inibidor de proteinase de Adenanthera pavonina sobre o desenvolvimento e atividade das proteinases intestinais de lagartas de Diatraea suchharalis (FABR., 1794)." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314519.

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Orientador: Maria Ligia Rodrigues Macedo<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-10T18:07:21Z (GMT). No. of bitstreams: 1 Silva_Walcianeda_M.pdf: 828879 bytes, checksum: 887dfe68d9499873f1fa12e23a404abd (MD5) Previous issue date: 2008<br>Resumo: Insetos fitopatógenos e outros animais utilizam enzimas digestivas tais como as amilases e proteases para processar nutrientes obtidos de plantas necessários ao seu desenvolvimento. A broca-da-cana Diatraea saccharalis é a principal praga da cana-de-açúcar no Brasil e

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12

Hvenegaard, Ana Paula Franco do Amaral. "Estudo retrospectivo do tratamento ambulatorial da úlcera indolente em cães da raça Boxer." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/10/10137/tde-02022012-134654/.

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Úlceras indolentes são úlceras corneais superficiais, espontâneas, que apresentam curso prolongado e que tendem a recidivar. Comumente observadas em cães de meia idade, da raça Boxer, provoca dor de início agudo e necessita de tratamento específico, já que este, quando não realizado de forma correta, pode prolongar o curso da lesão por semanas a meses. A doença é explicada por diversas alterações da superfície ocular. Com o objetivo de avaliar a eficácia dos tratamentos ambulatoriais preconizados no Serviço de Oftalmologia do Hospital Veterinário da Faculdade de Medicina Veterinária e Zootecni

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13

Tobouti, Priscila Lie. "Avaliação da expressão gênica da proteína aspartil secretada 2, 5 e 9 (SAP-2, SAP-5 e SAP-9) e sua correlação com a invasão epitelial por Candida albicans em modelo experimetal de estomatite protéica in vivo." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/25/25150/tde-27072011-110643/.

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A Estomatite protética associada a Candida (EPC) acomete a mucosa bucal em contato com próteses removíveis e, clinicamente, caracteriza-se por eritema com diferentes graus de inflamação. Esta doença é considerada de etiologia multifatorial, isto é, uma associação de fatores como trauma, falta de higienização, uso contínuo da prótese, hipersensibilidade ao material usado na dentadura, diabetes, terapia imunossupressora e infecção por fungo, como diferentes espécies de Candida. Os principais fatores de virulência deste fungo são a formação de hifas, dimorfismo, alterações fenotípicas, aderênci

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14

Monteiro, Júnior José Edvar. "Caracterização bioquímica, funcional e estrutural de duas cistatinas recombinantes de feijão-caupi." reponame:Repositório Institucional da UFC, 2012. http://www.repositorio.ufc.br/handle/riufc/18882.

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MONTEIRO JUNIOR, José Edvar. Caracterização bioquímica, funcional e estrutural de duas cistatinas recombinantes de feijão-caupi. 2012. 179 f.Tese (Doutorado em Bioquímica)-Universidade Federal do Ceará, Fortaleza-CE, 2012.<br>Submitted by Eric Santiago (erichhcl@gmail.com) on 2016-07-20T14:56:24Z No. of bitstreams: 1 2012_tese_jemonteirojunior.pdf: 22956458 bytes, checksum: 4912cb5f52b152df0d6dcc912bb7ccef (MD5)<br>Approved for entry into archive by José Jairo Viana de Sousa (jairo@ufc.br) on 2016-08-02T20:37:33Z (GMT) No. of bitstreams: 1 2012_tese_jemonteirojunior.pdf: 22956458 bytes, che

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15

Rukamp, Brian John. "Design, synthesis, and evaluation of novel thiobenzyl ester substrates and aza-peptide inhibitors for serine and cysteine proteases." Diss., Available online, Georgia Institute of Technology, 2004:, 2003. http://etd.gatech.edu/theses/available/etd-04072004-180202/unrestricted/rukamp%5Fbrian%5Fj%5F200312%5Fphd.pdf.

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16

Rukamp, Karrie Eileen Adlington. "Design and synthesis of inhibitors for serine and cysteine proteases." Diss., Available online, Georgia Institute of Technology, 2004:, 2003. http://etd.gatech.edu/theses/available/etd-04082004-180343/unrestricted/rukamp%5Fkarrie%5Fe%5Fa%5F200312%5Fphd.pdf.

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17

Leung, Donmienne Doen Mun. "Studies of serine and cysteine protease inhibitors /." St. Lucia, Qld, 2001. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16491.pdf.

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18

Kraunsoe, James A. E. "Inhibitors of serine proteinases." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318814.

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19

Kingsbury, Oliver William. "The inhibition of cysteine proteinases." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360390.

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20

Johnstone, Thomas W. "Neutrophil serine proteinases and autoimmunity." Thesis, Queen's University Belfast, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241372.

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21

Lockwood, B. C. "Proteinases in trichomonads and trichomoniasis." Thesis, University of Stirling, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.377537.

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22

Rodrigues, Janaina Aparecida de Oliveira. "Produção de anticorpos monoclonais para uma proteinase acida extracelular (aspartil proteinase) de Candida spp." [s.n.], 2004. http://repositorio.unicamp.br/jspui/handle/REPOSIP/289363.

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Orientador: Jose Francisco Hofling<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba<br>Made available in DSpace on 2018-08-03T21:48:19Z (GMT). No. of bitstreams: 1 Rodrigues_JanainaAparecidadeOliveira_D.pdf: 285480 bytes, checksum: 4c39c1efe89bca6b4e60413ccebce99d (MD5) Previous issue date: 2004<br>Doutorado

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23

Nycander, Maria. "Interaction of cystatins with cysteine proteinases /." Uppsala : Swedish Univ. of Agricultural Sciences (Sveriges lantbruksuniv.), 1998. http://epsilon.slu.se/avh/1998/91-576-5428-X.gif.

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24

Cullen, Breda M. "The characterisation of breast tumour proteinases." Thesis, Queen's University Belfast, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317436.

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25

Jupp, Raymond A. "Substrates and inhibitors of aspartic proteinases." Thesis, Cardiff University, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.238215.

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26

Valler, M. J. "Substrates and inhibitors of aspartic proteinases." Thesis, Bucks New University, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376428.

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27

Knolle, Martin Daniel. "Characterisation of proteinases in pulmonary pathology." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608015.

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28

Tamaki, Fabio Kendi. "Serina proteinases digestivas de insetos-modelo." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-25052011-145048/.

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Tripsinas e quimotripsinas, enzimas pertencentes à classe das serina proteinases, são as principais enzimas proteolíticas digestivas presentes no intestino médio de insetos de diversas ordens. Entretanto, enzimas de diferentes insetos possuem propriedades cinéticas distintas, sendo os motivos dessas diferenças especulados. Precipitações por sulfato de amônio das tripsinas de Tenebrio molitor, Diatraea saccharalis e Spodoptera frugiperda mostram que insetos Lepidópteros possuem serina proteinases mais hidrofóbicas, que foi confirmado através de cromatografias de interação hidrofóbica e da análi

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29

Pope, Brent Karl. "Factors Affecting Growth of Proteinase Positive and Proteinase Negative Streptococcus cremoris UC310 in Ultrafiltered Milk Retentate." DigitalCommons@USU, 1987. https://digitalcommons.usu.edu/etd/5356.

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Whole milks were adjusted to pH 5.8, 6.2, or 6. 7 with HCl and batch pasteurized at 63°C for 30 min. Each was concentrated 5:1 (40% total solids) through a single tube polysulfone membrane Abcor ultrafiltration unit. Lactose (L), casein hydrolysate (CH), and one of two brands of yeast extract (YE1, YE2) were added into cooled retentates at 0.1, 0.3, 0.5, 0. 7 or 0.9% and equilibrated overnight at 4°C. Five percent proteinase positive (Prt+) Streptococcus cremoris UC 310+ (v/w) milk based culture was added. Unfortified retentate was also inoculated with 0.1, 0.3, 0.5, 0. 7 or 0.9% starter and p

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30

Rawat, Reetika. "Characterization of the promoter of SmCP, the gene encoding Solanum melongena cysteine proteinase." Thesis, Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/hkuto/record/B34740156.

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31

Arruda, Ligia Hansen. "Caracterização estrutural da interação de serino proteinases de Spodoptera frugiperda (Lepidoptera: Noctuidae) e inibidores de proteinases de plantas." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/11/11137/tde-24052011-091301/.

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As plantas desenvolveram diferentes mecanismos para reduzir o ataque de insetos, incluindo compostos protéicos de defesa, como os inibidores de proteinases (IPs). Os insetos, ao longo da evolução, desenvolveram estratégias para superar as barreiras defensivas das plantas, permitindo a sua alimentação e desenvolvimento, como a super expressão de genes de enzimas digestivas sensíveis e insensíveis aos IPs de plantas. Uma das abordagens desse trabalho foi identificar novas serinoproteinases no intestino de lagartas de Spodoptera frugiperda. Duas novas quimotripsinas e trê novas tripsinas foram id

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32

Leisegang, Rena. "Proteinase A und Schaumstabilität biochemische Untersuchungen der Wechselwirkungen von Proteinase A aus Saccharomyces cerevisiae und schaumaktivem Lipidtransferprotein /." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=969247214.

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33

Cruz, Carlos Eduardo Silva da. "Caracterização de proteinases envolvidas na geração de peptídeos antimicrobianos no intestino de Rhipicephalus (Boophilus) microplus." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/42/42135/tde-25032010-161909/.

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Sabe-se que a hemoglobina é uma rica fonte de peptídeos antimicrobianos (hemocidinas). A primeira hemocidina derivada da hemoglobina bovina caracterizada em carrapatos foi o peptídeo Hb33-61, que é ativo contra bactérias gram-positivas e fungos. Acredita-se que tais hemocidinas sejam geradas proteoliticamente no intestino do carrapato. Neste trabalho nós caracterizamos bioquimicamente uma catepsina D, designada BmAP. A análise da expressão gênica por qPCR mostrou que ela é expressa predominantemente no intestino. Através de LC-MS/MS, determinamos a especificidade de clivagem da BmAP utilizando

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34

Schnepel, Jörn. "Klonierung, Expression und Charakterisierung kryptischer Fibronektin-Proteinasen." [S.l. : s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=969330472.

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35

Turkington, Philip Thomas. "The role of polymorphonuclear proteinases in haemostasis." Thesis, Queen's University Belfast, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317075.

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36

Rowan, Andrew D. "The pineapple proteinases : characterization and clinical use." Thesis, Open University, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.290495.

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37

Nattrass, Gregory Scott. "Molecular and functional characterisation of a system ASC-like neutral amino acid transporter expressed in the wool follicle /." Title page, contents and abstract only, 2000. http://web4.library.adelaide.edu.au/theses/09ANP/09anpn284.pdf.

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38

Li, Yang 1974. "Characterization of two type II transmembrane serine proteases, hepsin and corin." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=79034.

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Type II transmembrane serine proteases (TTSPs), including hepsin and corin, are a new class of cell surface catalytic enzymes. In the present study, a non-transmembrane isoform of hepsin, named hepsin/-TM that originates from alternative splicing, was identified. Unlike the transmembrane hepsin isoform, this non-transmembrane isoform was distributed within the cytoplasm and likely to be modified after translation. Real-time PCR experiments revealed that hepsin was expressed in all tested human tissues, but hepsin/-TM only in kidney, brain and lung tissues. Significantly, hepsin/-TM was

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39

McKeown, Brendan Gerard. "A study of the 2A and 3C mediated cleavage events in the processing of the foot-and-mouth disease virus polyprotein." Thesis, Queen's University Belfast, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318800.

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40

Sit, Mae-Le. "The role of serine proteases in angiogenesis /." St. Lucia, Qld, 2001. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16412.pdf.

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41

Du, Bingfan Groutas William C. "Novel inhibitors of human leukocyte proteinase 3." Diss., Click here for available full-text of this thesis, 2006. http://library.wichita.edu/digitallibrary/etd/2006/t013.pdf.

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Thesis (M.S.)--Wichita State University, Dept. of Chemistry.<br>"May 2006." Title from PDF title page (viewed on October 19, 2006). Thesis adviser: William C. Groutas. Includes bibliographic references (leaves 56-61).

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42

Roy, Samir. "Vascular effects of proteinase receptor activating peptides." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0011/MQ34991.pdf.

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43

Bernstein, Nina Khazanovich. "Structural studies of malarial aspartic proteinase activation." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0014/NQ59937.pdf.

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44

Tehrani, Kamin A. "Synthesis and kinetics of cysteine proteinase inhibitors." Thesis, Georgia Institute of Technology, 1991. http://hdl.handle.net/1853/26967.

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45

Souto, Maior Ana M. "Proteinase production from an alkalophilic Bacillus species." Thesis, University of Manchester, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315973.

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46

Chetland, J. "The design and synthesis of proteinase inhibitors." Thesis, University of Liverpool, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.372687.

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47

Winterburn, Timothy John. "Engineering and design of aspartic proteinase inhibitors." Thesis, Cardiff University, 2005. http://orca.cf.ac.uk/55593/.

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Aspartic proteinases are of considerable interest to the pharmaceutical, agrochemical and food industries. Many small molecule inhibitors have been synthesised chemically to block the action of individual members of this proteinase family. In contrast, only a handful of naturally-occurring, gene-encoded inhibitors of aspartic proteinases are known. One such inhibitor is IA3, an intrinsically unstructured 68-residue cytosolic protein from Saccharomyces cerevisiae, which operates through an unprecedented mode of action. On contacting the target enzyme, residues 2-32 form an amphipathic a-helix t

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48

Chin, Ai-Yen. "Proteinase-activated receptor 4 and cell apoptosis." Thesis, University of Hull, 2013. http://hydra.hull.ac.uk/resources/hull:8124.

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In response to injury, the collagen-producing cells fibroblasts and myofibroblasts play an important role in promoting extracellular matrix deposition and release of inflammatory mediators in order to repair the damaged tissue. However, persistence and over-activity of these cells is associated with excessive collagen deposition and hence development of brosis, a pathological scarring process that leads to destruction of organ architecture and impairment of organ function. Removal of fibroblasts and myofibroblasts during fibrogenesis by apoptosis is therefore required for the normal resolution

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Dixit, V. S. "Proteinase production and hydrocarbon degradation by actinomycetes." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1999. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2921.

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Ally, Nafisa. "The specificity of proteinase-adhesins from Porphyromonas gingivalis." Monash University, Dept. of Biochemistry and Molecular Biology, 2003. http://arrow.monash.edu.au/hdl/1959.1/9477.

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