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Articles de revues sur le sujet « Radioprotective effect »

Auteur : Grafiati

Publié le 7 juin 2025

Mis à jour le 2 août 2025

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1

Neta, R., J. J. Oppenheim, R. D. Schreiber, R. Chizzonite, G. D. Ledney, and T. J. MacVittie. "Role of cytokines (interleukin 1, tumor necrosis factor, and transforming growth factor beta) in natural and lipopolysaccharide-enhanced radioresistance." Journal of Experimental Medicine 173, no. 5 (1991): 1177–82. http://dx.doi.org/10.1084/jem.173.5.1177.

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Studies of radioresistance and radioprotection provide an excellent in vivo model for dissection of the pathophysiological role of cytokines. The availability of neutralizing antibodies to cytokines has made it possible to assess the contribution of cytokines to host defense and repair processes involved in radioresistance and radioprotection. Administration of anti-interleukin 1 receptor (IL-1R) antibody (35F5) or anti-tumor necrosis factor (TNF) antibody (TN3 19.12) reduced survival of irradiated CD2F1 mice. These results demonstrate conclusively that natural levels of IL-1 and TNF contribut

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Pucci, Gaia, Gaetano Savoca, Giuseppina Iacoviello, Giorgio Russo, Giusi I. Forte, and Vincenzo Cavalieri. "Curcumin’s Radioprotective Effects on Zebrafish Embryos." Antioxidants 13, no. 11 (2024): 1281. http://dx.doi.org/10.3390/antiox13111281.

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Radiation modifiers are largely studied for their contribution to enlarging the treatment window. Curcumin is already known for its antioxidant properties; however, its role as a radioprotector in preclinical studies is affected by the well-known low absorption and bioavailability of curcumin. In this study, curcumin’s radioprotection ability has been evaluated in zebrafish larvae, by taking advantage of quantifying curcumin absorption and evaluating its fluorescence in transparent embryos. A curcumin range of 1–10 μM was tested to select the non-toxic concentrations to be used for a pre-treat

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Kim, Jun-Young, Jong-Hyung Park, Sun-Min Seo, et al. "Radioprotective effect of newly synthesized toll-like receptor 5 agonist, KMRC011, in mice exposed to total-body irradiation." Journal of Radiation Research 60, no. 4 (2019): 432–41. http://dx.doi.org/10.1093/jrr/rrz024.

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Abstract Exposure to ionizing radiation leads to severe damages in radiosensitive organs and induces acute radiation syndrome, including effects on the hematopoietic system and gastrointestinal system. In this study, the radioprotective ability of KMRC011, a novel toll-like receptor 5 (TLR5) agonist, was investigated in C57BL6/N mice exposed to lethal total-body gamma-irradiation. In a 30-day survival study, KMRC011-treated mice had a significantly improved survival rate compared with control after 11 Gy total-body irradiation (TBI), and it was found that the radioprotective activity of KMRC01

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Musa, Omyan, Esmaely, and Shabeeb. "Radioprotective Effect of Hesperidin: A Systematic Review." Medicina 55, no. 7 (2019): 370. http://dx.doi.org/10.3390/medicina55070370.

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Background and objectives: Ionizing radiation (IR) has been of immense benefit to man, especially for medical purposes (diagnostic imaging and radiotherapy). However, the risks of toxicity in healthy normal cells, leading to cellular damage as well as early and late side effects, have been major drawbacks. The aim of this study was to evaluate the radioprotective effect of hesperidin against IR-induced damage. Materials and Methods: The preferred reporting items for systematic reviews and meta-analyses (PRISMA) were applied in reporting this study. A search was conducted using the electronic d

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Azmoonfar, Rasool, Masoud Moslehi, and Daryoush Shahbazi-Gahrouei. "Radioprotective Effect of Selenium Nanoparticles: A Mini Review." IET Nanobiotechnology 2024 (January 25, 2024): 1–8. http://dx.doi.org/10.1049/2024/5538107.

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Background and Objectives. Ionizing radiation is widely used in medical imaging for diagnosis and in radiotherapy for the treatment of various medical conditions. However, ionizing radiation can cause damage to healthy cells and tissues, leading to side effects and an increased risk of cancer and other diseases over time. This study aimed to evaluate the possible radioprotective effect of selenium nanoparticles against the damage caused by ionizing radiation. Materials and Methods. This study followed the PRISMA reporting guidelines to present the results. A comprehensive search was performed

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Lukashin, Boris, Alexander Grebenyuk, and Victor Zatsepin. "RADIOPROTECTIVE EFFECT OF HEPARIN." Kontakt 13, no. 4 (2011): 478–83. http://dx.doi.org/10.32725/kont.2011.052.

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Barbera, N., T. Palmucci, U. Scapagnini, S. Greco, and R. Bernardini. "Radioprotective effect of thymopentin." Pharmacological Research 22 (September 1990): 28. http://dx.doi.org/10.1016/s1043-6618(09)80084-4.

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Wang, Zhiyun, Haihua Shang, Wenfeng Gou та ін. "Protective effect of Camellia nitidissima Chi on γ rays radiation-induced hematopoietic and gastrointestinal damage". Acupuncture and Herbal Medicine 4, № 4 (2024): 487–99. https://doi.org/10.1097/hm9.0000000000000127.

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Objective: Camellia nitidissima Chi, a Chinese medicine commonly used by ethnic minorities in Guangxi, China, is beneficial for clearing heat, detoxifying, inducing diuresis, and suppressing swelling. It has various pharmacological properties, including antitumor, anti-inflammatory, and antioxidant. However, its potential application in radioprotection remains unclear. In this study, we aimed to determine whether Camellia nitidissima Chi has radioprotective effects against radiation-induced gastrointestinal and hematopoietic damage. Methods: The 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radica

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Mahran, Yasmen F., Amira M. Badr, Alhanouf Aldosari, Raghad Bin-Zaid та Hind N. Alotaibi. "Carvacrol and Thymol Modulate the Cross-Talk between TNF-α and IGF-1 Signaling in Radiotherapy-Induced Ovarian Failure". Oxidative Medicine and Cellular Longevity 2019 (20 серпня 2019): 1–10. http://dx.doi.org/10.1155/2019/3173745.

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Premature ovarian failure (POF) is a common cause of infertility in premenopausal women who are unavoidably exposed to cytotoxic therapy. Radiotherapy is one of the most effective cytotoxic treatments. However, the radiosensitivity of ovarian tissues limits its therapeutic outcome and results in the depletion of the primordial follicle and loss of fertility. Therefore, the need for an effective radioprotective therapy is evident especially when none of the current clinically used modalities for radioprotection succeeds efficiently. The present study investigated the potential radioprotective e

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Qin, Xiang-Yang, Gui-Rong Ding, Xiao-Wu Wang, Juan Tan, Guo-Zhen Guo, and Xiao-Li Sun. "Synthesis, characterisation, cytotoxicity and radioprotective effect of novel chiral nitronyl nitroxyl radicals." Journal of Chemical Research 2009, no. 8 (2009): 511–14. http://dx.doi.org/10.3184/030823409x12474221035163.

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Nitroxyl compounds have been previously investigated as potential radioprotection drugs. To develop new radioprotectors, two kinds of novel chiral nitronyl nitroxyl radicals: L- tert-butyl 2-(4, 5-dihydro-4, 4, 5, 5-tetramethyl-3-oxido-1 H-imidazol-3-ium-1-oxyl-2-yl) pyrrolidine-1-carboxylate ( L-NNP) and L- tert-butyl 2-[(4-(4, 5-dihydro-4,4,5,5-tetramethyl-3-oxido-1 H-imidazol-3-ium-1-oxyl-2-yl)-2-methoxyphenoxy)methyl] pyrrolidine-1-carboxylate ( L-NNVP) have been synthesised. The cytotoxic and radioprotective effects of these two compounds were then evaluated in rat glioma C6 cells.

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Kalechman, Y., A. Zuloff, M. Albeck, G. Strassmann, and B. Sredni. "Role of endogenous cytokines secretion in radioprotection conferred by the immunomodulator ammonium trichloro(dioxyethylene-0-0')tellurate." Blood 85, no. 6 (1995): 1555–61. http://dx.doi.org/10.1182/blood.v85.6.1555.bloodjournal8561555.

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The immunomodulator ammonium trichloro(dioxyethylene-0–03′)tellurate (AS101) has previously been found by us to have radioprotective properties when injected into mice before sublethal and lethal doses of irradiation. AS101 also was found to protect mice from hematopoietic damage caused by various chemotherapeutic drugs. Based on these findings, phase II clinical trials with cancer patients treated with AS101, in combination with chemotherapy, are currently underway. In the present study, we wanted to assess the role of several cytokines in the radioprotection conferred by AS101. We show that

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Lledó, Inés, Blanca Ibáñez, Ana Melero, et al. "Vitamins and Radioprotective Effect: A Review." Antioxidants 12, no. 3 (2023): 611. http://dx.doi.org/10.3390/antiox12030611.

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The radioprotective effect ex vivo, in vitro and in vivo of vitamins was reviewed using PubMed and Embase and conducted according to the PRISMA statement. A total of 38 articles were included in this review, which includes the radioprotective effect of vitamins from ex vivo, in vitro and in vivo studies. Vitamins A, C, D and E were used alone, in combination or with other nutritional and non-nutritional compounds. The use of vitamins in natural form or supplementation can be useful to reduce the radiation effect in the body, organs and/or cells. Only four (A, C, D and E) out of thirteen vitami

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Shaeffer, James, Karl A. Schellenberg, Cathy H. Seymore, Timothy E. Schultheiss, and Anas M. El-Mahdi. "Radioprotective Effect of Polyethylene Glycol." Radiation Research 107, no. 1 (1986): 125. http://dx.doi.org/10.2307/3576856.

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Mehandjiev, A., G. Vassilev, and P. Yonova. "Radioprotective Effect of Thiourea Derivatives." Biotechnology & Biotechnological Equipment 7, no. 2 (1993): 66–71. http://dx.doi.org/10.1080/13102818.1993.10818697.

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Bidzilya, V. A., L. P. Golovkova, N. N. Beregovskaya, et al. "Radioprotective effect of immobilized cystamine." Pharmaceutical Chemistry Journal 25, no. 11 (1991): 782–86. http://dx.doi.org/10.1007/bf00767257.

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Кurinnyi, D. A., S. R. Rushkovsky, O. B. Dybska, G. V. Dubrovina, and M. A. Pilinska. "ASTAXANTHIN MODIFIES CLASTOGENIC EFFECTS OF IONIZING RADIATION IN VITRO IN PERIPHERAL BLOOD LYMPHOCYTES OF THE PERSONS RECOVERED FROM ACUTE RADIATION SICKNESS." Experimental Oncology 38, no. 4 (2016): 280–82. http://dx.doi.org/10.31768/2312-8852.2016.38(4):280-282.

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Aim: To assess radioprotective activity of astaxanthin toward radiation-induced in vitro cytogenetic effects in human peripheral blood lymphocytes (PBL). Materials and Methods: PBL from the cleanup workers exposed to ionizing radiation at high doses in 1986 during accident on Chornobyl nuclear power plant and who were diagnosed with acute radiation sickness of the first and second degrees, were cultured in vitro. Astaxanthin was added into the culture medium at a final concentration of 20.0 µg/ml, prior to γ-irradiation of PBL in vitro at a dose of 1 Gy. The slides of metaphase chromosomes wer

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Šinkorová, Zuzana, Alžběta Filipová, Jiřina Vávrová, et al. "INVESTIGATION OF THE RADIOPROTECTIVE EFFECT OF ORTHOVANADATE IN MICE AFTER TOTAL BODY IRRADIATION." Radiation Protection Dosimetry 186, no. 2-3 (2019): 149–54. http://dx.doi.org/10.1093/rpd/ncz192.

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Abstract The increasing risk of acute large-scale exposure of ionising irradiation on the population underlines the necessity of developing effective radioprotective and mitigating agents. The aim of this work was to investigate the effect of sodium orthovanadate pre-treatment on mice exposed to high doses of gamma rays (from 5 to 13 Gy). The determination of median lethal dose within 30 days confirmed that orthovanadate applied to total-body-irradiated mice intra-peritoneally has a radioprotective but not a mitigating effect. With orthovanadate pre-treatment, the composition of cellularity in

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Mechshanova, Anna, Vladilen Polyakov, and Temenuzhka Radoykova. "The study of the natural substances obtained from the poplar buds and their use for protection against the action of ionizing radiation." ScienceRise: Pharmaceutical Science, no. 3(43) (June 30, 2023): 79–86. http://dx.doi.org/10.15587/2519-4852.2023.271837.

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Currently, natural plant extracts, which include biologically active substances, are increasingly used to produce medicines and cosmetics. In connection with the dangers of a radioecological crisis, special attention is paid to finding ways to protect against the effects of chronic exposure to low-intensity ionizing radiation in natural conditions. Currently, there is no ideal and safe radioprotective agent available, and we are seeing a great effort to find these agents from natural sources. Poplar extract is possible for use as a radioprotective shield from γ-radiation. Samples of protective

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Kulkarni, Shilpa, Kushal Chakraborty, K. Sree Kumar, Tzu-Cheg Kao, Martin Hauer-Jensen, and Sanchita P. Ghosh. "Synergistic Radioprotection by Gamma-Tocotrienol and Pentoxifylline: Role of cAMP Signaling." ISRN Radiology 2013 (July 7, 2013): 1–11. http://dx.doi.org/10.5402/2013/390379.

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Purpose. This study was designed to determine the efficacy and mechanisms of radioprotection by the combination of gamma-tocotrienol (GT3) and pentoxifylline (PTX) against acute radiation injury. Materials and Methods. Post-irradiation survival was monitored to determine the most efficacious dose and time of administration of PTX. Dose reduction factor (DRF) was calculated to compare the radioprotective efficacy of the combination. To determine the mechanism of synergistic radioprotection by the combination, mevalonate or calmodulin were coadministered with the GT3-PTX combination. Mevalonate

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Pan, Jianru, Huocong He, Ying Su, et al. "GST-TAT-SOD: Cell Permeable Bifunctional Antioxidant Enzyme—A Potential Selective Radioprotector." Oxidative Medicine and Cellular Longevity 2016 (2016): 1–13. http://dx.doi.org/10.1155/2016/5935080.

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Superoxide dismutase (SOD) fusion of TAT was proved to be radioprotective in our previous work. On that basis, a bifunctional recombinant protein which was the fusion of glutathione S-transferase (GST), SOD, and TAT was constructed and named GST-TAT-SOD. Herein we report the investigation of the cytotoxicity, cell-penetrating activity, and in vitro radioprotective effect of GST-TAT-SOD compared with wild SOD, single-function recombinant protein SOD-TAT, and amifostine. We demonstrated that wild SOD had little radioprotective effect on irradiated L-02 and Hep G2 cells while amifostine was prote

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Lazarova, Galina I., and Dobromir V. Palazov. "A method for radioprotective effect evaluation." Current Microbiology 25, no. 1 (1992): 31–34. http://dx.doi.org/10.1007/bf01570079.

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Hirano, Shin-ichi, Yusuke Ichikawa, Bunpei Sato, Haru Yamamoto, Yoshiyasu Takefuji, and Fumitake Satoh. "Molecular Hydrogen as a Potential Clinically Applicable Radioprotective Agent." International Journal of Molecular Sciences 22, no. 9 (2021): 4566. http://dx.doi.org/10.3390/ijms22094566.

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Although ionizing radiation (radiation) is commonly used for medical diagnosis and cancer treatment, radiation-induced damages cannot be avoided. Such damages can be classified into direct and indirect damages, caused by the direct absorption of radiation energy into DNA and by free radicals, such as hydroxyl radicals (•OH), generated in the process of water radiolysis. More specifically, radiation damage concerns not only direct damages to DNA, but also secondary damages to non-DNA targets, because low-dose radiation damage is mainly caused by these indirect effects. Molecular hydrogen (H2) h

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Ritter, G. S., V. P. Nikolin, N. A. Popova, et al. "Characteristic of the active substance of the Saccharomyces cerevisiae preparation having radioprotective properties." Vavilov Journal of Genetics and Breeding 24, no. 6 (2020): 643–52. http://dx.doi.org/10.18699/vj20.658.

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The paper describes some biological features of the radioprotective effect of double-stranded RNA preparation. It was found that yeast RNA preparation has a prolonged radioprotective effect after irradiation by a lethal dose of 9.4 Gy. 100 % of animals survive on the 70th day of observation when irradiated 1 hour or 4 days after 7 mg RNA preparation injection, 60 % animals survive when irradiated on day 8 or 12. Time parameters of repair of double-stranded breaks induced by gamma rays were estimated. It was found that the injection of the RNA preparation at the time of maximum number of double

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Filimonova, M. V., A. S. Saburova, L. I. Shevchenko, V. M. Makarchuk, A. A. Lychagin, and A. S. Filimonov. "Influence of the type of salt-forming acids on the antiradiation activity of T1023 analogs – salts of N-isobutanoyl-S-isopropylisothiourea." Radiatsionnaya Gygiena = Radiation Hygiene 14, no. 1 (2021): 68–74. http://dx.doi.org/10.21514/1998-426x-2021-14-1-68-74.

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According to leading experts, the vast arsenal of radioprotective agents available in the world today does not fully meet modern practical needs, both in the field of radiation protection, and in the prevention and treatment of complications of radiotherapy. The purpose of the study was to evaluate the effect of the salt-forming acids type on the radioprotective activity of NOS inhibitor T1023. The chemical part of this study included methods of chemical synthesis, physicochemical and elemental analysis. Pharmacological part – assessment of acute toxicity using V.B. Prozorovsky express method

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Pruijt, Johannes F. M., Yvette van Kooyk, Carl G. Figdor, Roel Willemze та Willem E. Fibbe. "Murine Hematopoietic Progenitor Cells With Colony-Forming or Radioprotective Capacity Lack Expression of the β2-Integrin LFA-1". Blood 93, № 1 (1999): 107–12. http://dx.doi.org/10.1182/blood.v93.1.107.

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Abstract Recently, we have demonstrated that antibodies that block the function of the β2-integrin leukocyte function-associated antigen-1 (LFA-1) completely abrogate the rapid mobilization of hematopoietic progenitor cells (HPC) with colony-forming and radioprotective capacity induced by interleukin-8 (IL-8) in mice. These findings suggested a direct inhibitory effect of these antibodies on LFA-1–mediated transmigration of stem cells through the bone marrow endothelium. Therefore, we studied the expression and functional role of LFA-1 on murine HPC in vitro and in vivo. In steady state bone m

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Pruijt, Johannes F. M., Yvette van Kooyk, Carl G. Figdor, Roel Willemze та Willem E. Fibbe. "Murine Hematopoietic Progenitor Cells With Colony-Forming or Radioprotective Capacity Lack Expression of the β2-Integrin LFA-1". Blood 93, № 1 (1999): 107–12. http://dx.doi.org/10.1182/blood.v93.1.107.401k14_107_112.

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Recently, we have demonstrated that antibodies that block the function of the β2-integrin leukocyte function-associated antigen-1 (LFA-1) completely abrogate the rapid mobilization of hematopoietic progenitor cells (HPC) with colony-forming and radioprotective capacity induced by interleukin-8 (IL-8) in mice. These findings suggested a direct inhibitory effect of these antibodies on LFA-1–mediated transmigration of stem cells through the bone marrow endothelium. Therefore, we studied the expression and functional role of LFA-1 on murine HPC in vitro and in vivo. In steady state bone marrow ± 5

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Pouri, Maysa, Zahra Shaghaghi, Arash Ghasemi, and Seyed Jalal Hosseinimehr. "Radioprotective Effect of Gliclazide as an Anti-Hyperglycemic Agent Against Genotoxicity Induced by Ionizing Radiation on Human Lymphocytes." Cardiovascular & Hematological Agents in Medicinal Chemistry 17, no. 1 (2019): 40–46. http://dx.doi.org/10.2174/1871525717666190524092918.

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Objectives: Gliclazide (GL) is widely used to reduce hyperglycemia in diabetic patients. The aim of this study was to investigate the protective effect of GL against chromosome damage induced by ionizing radiation in human blood lymphocytes. Methods: In this experimental study, peripheral blood samples were collected from human volunteers and treated with GL at various concentrations (5, 25, 50 or 100 μM) for three hours. Then samples were irradiated to X-ray (1.5 Gy). Blood samples were cultured with mitogenic stimulation. The frequencies of micronuclei in cytokinesis-blocked binucleated lymp

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Melnov, S. B., P. M. Marozik, and N. I. Melnova. "INFLUENCE OF MELANIN ON THE INDUCTION OF MICRONUCLEI AND APOPTOSIS AFTER RADIATION INFLUENCE." Health and Ecology Issues 1, no. 2 (2004): 28–34. http://dx.doi.org/10.51523/2708-6011.2004-1-2-4.

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The influence of melanin pigment on micronuclei frequency and «genetic» apoptosis induction in human peripheral blood lymphocytes after low dose radiation exposure has been studied. Melanin is known to be natural substance with shown radioprotective activity. Results of the investigation revealed that melanin has no cytotoxic effect and its addition to the cell medium one hour before irradiation was accompanied by decrease of micronuclei frequency and apoptosis level in irradiatd lymphocytes, thus showing radioprotective effect.

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Ibáñez, Blanca, Ana Melero, Alegría Montoro, Nadia San Onofre, and Jose M. Soriano. "Radioprotective Effects from Propolis: A Review." Molecules 28, no. 15 (2023): 5842. http://dx.doi.org/10.3390/molecules28155842.

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Propolis is a natural bee-produced substance with antimicrobial, anti-inflammatory, and wound-healing properties, containing some components from the leaves, buds and resins of plants. It has been used for centuries for various health benefits. In this manuscript, our group reviewed the radioprotective effect of propolis using PubMed and Embase, and our review was conducted according to the PRISMA statement. Finally, 27 articles were included in this review, which includes the radioprotective effect of propolis from cell-based studies (n = 8), animal models (n = 14), and human trials (n = 5).

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Nikolova, Nevena, Donika Ivanova, and Zvezdelina Yaneva. "In Vivo Radioprotective Potential of Newly Synthesized Azomethine and Styrylquinoline Derivatives and a Natural Polyphenol: A Preliminary Study." Life 12, no. 3 (2022): 346. http://dx.doi.org/10.3390/life12030346.

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The aim of the present study was to investigate the radioprotective activity of silymarin, a plant substance with hepatoprotective activity, of four newly synthesized structural derivatives of anthranilic acid azomethines, and alkyl-2-styrylquinolinic acid, as well as to establish and assess the influence of the solvent type and bioactive compound dose on the in vivo radioprotective potential of the natural and novel synthetic compounds. Male Wistar strain rats weighing 110–120 g were used for the in vivo experiments. Fifteen minutes after i.p. injection of the compounds, the experimental anim

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Gramatyka, Michalina. "The Radioprotective Activity of Resveratrol—Metabolomic Point of View." Metabolites 12, no. 6 (2022): 478. http://dx.doi.org/10.3390/metabo12060478.

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Resveratrol, a plant-derived polyphenol, is an intensively studied compound with widely documented positive effects on health. Antioxidant activity is the property most often mentioned as responsible for its beneficial effects. Therefore, since the adverse effect of ionizing radiation is primarily related to the induction of oxidative stress, the question arises of whether the use of resveratrol could have a radioprotective effect. This paper summarizes the data on the cytoprotective activity of resveratrol and pieces of evidence for the potential interplay between response to radiation and re

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Peng, Xiao Chun, Jiang Rong Huang, Si Wei Wang, et al. "Traditional Chinese Medicine in Neuroprotection after Brain Insults with Special Reference to Radioprotection." Evidence-Based Complementary and Alternative Medicine 2018 (November 26, 2018): 1–14. http://dx.doi.org/10.1155/2018/2767208.

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With rapidly increased construction of nuclear power plants worldwide to reduce energy shortage and subsequent environment contamination, routine use of radiotherapy and radiodiagnosis equipment in the clinical medicine, the research on the health effect of radiation exposure has become a very important area to explore. Traditional Chinese Medicine (TCM) may be an ideal candidate therapy as it usually produces fewer side effects even with long-term administration. In this paper, we reviewed current therapeutic approaches to prevent radiation-induced brain neuropathological and functional chang

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Bala, Madhu, and Harish Chandra Goel. "Radioprotective Effect of Podophyllotoxin in Saccharomyces cerevisiae." Journal of Environmental Pathology, Toxicology and Oncology 23, no. 2 (2004): 139–44. http://dx.doi.org/10.1615/jenvpathtoxoncol.v23.i2.60.

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Nizamov, R. N., G. V. Konyukhov, D. T. Sharifullina, A. S. Titov, and M. M. Shakurov. "RADIOPROTECTIVE EFFECT OF SUBSTANCES OF ZOOGENIC ORIGIN." Veterinarny Vrach, no. 2 (2019): 62–67. http://dx.doi.org/10.33632/1998-698x.2019-2-62-67.

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Romodin, L. A., and N. P. Lysenko. "The Radioprotective Effect of Chlorophyll-Based Drugs." Biophysics 67, no. 1 (2022): 78–84. http://dx.doi.org/10.1134/s0006350922010158.

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Romodin, L. A., and N. P. Lysenko. "The Radioprotective Effect of Chlorophyll-Based Drugs." Biophysics 67, no. 1 (2022): 78–84. http://dx.doi.org/10.1134/s0006350922010158.

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Choi, Noah C. "Radioprotective effect of amifostine in radiation pneumonitis." Seminars in Oncology 30 (December 2003): 10–17. http://dx.doi.org/10.1053/j.seminoncol.2003.11.038.

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Kovaciková, Zuzana, Darina Chorvatovičcová, and Emil Ginter. "P X.16 Radioprotective effect of stobadine." Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 379, no. 1 (1997): S74. http://dx.doi.org/10.1016/s0027-5107(97)82853-9.

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El-Nahas, Soheir M., Fathy E. Mattar, and Amal A. Mohamed. "Radioprotective effect of vitamins C and E." Mutation Research Letters 301, no. 2 (1993): 143–47. http://dx.doi.org/10.1016/0165-7992(93)90037-v.

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Suresh Reddy, Jannapally, Vobalaboina Venkateswarlu, and Gerben A. Koning. "Radioprotective effect of transferrin targeted citicoline liposomes." Journal of Drug Targeting 14, no. 1 (2006): 13–19. http://dx.doi.org/10.1080/10611860600613241.

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Karnaukhova, N. A., L. A. Sergievich, S. I. Sobruchev, I. A. Manokhina, A. V. Rodionov, and V. N. Karnaukhov. "Radioprotective effect of a herbal product soma." Biophysics 52, no. 1 (2007): 87–91. http://dx.doi.org/10.1134/s0006350907010149.

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Patchen, M. L., M. M. D'Alesandro, I. Brook, W. F. Blakely, and T. J. MacVittie. "Glucan: Mechanisms Involved in Its “Radioprotective” Effect." Journal of Leukocyte Biology 42, no. 2 (1987): 95–105. http://dx.doi.org/10.1002/jlb.42.2.95.

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Olivares, Amparo, Miguel Alcaraz-Saura, Daniel Gyingiri Achel, Juan de Dios Berná-Mestre, and Miguel Alcaraz. "Radiation-Induced Bystander Effect: Loss of Radioprotective Capacity of Rosmarinic Acid In Vivo and In Vitro." Antioxidants 10, no. 2 (2021): 231. http://dx.doi.org/10.3390/antiox10020231.

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In radiation oncology, the modulation of the bystander effect is a target both for the destruction of tumor cells and to protect healthy cells. With this objective, we determine whether the radioprotective capacity of rosmarinic acid (RA) can affect the intensity of these effects. Genoprotective capacity was obtained by determining the micronuclei frequencies in in vivo and in vitro assays and the cell survival was determined by the (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay) (MTT) assay in three cell lines (PNT2, TRAMPC1 and B16F10), both in direct exposure to X-rays

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V. K., Mukhomorov. "Simulation of the Radioprotective Action of Mercaptoethylamine Derivatives and its Analogues with their Quantum-Chemical and Information Features." MOLECULAR SCIENCES AND APPLICATIONS 2 (December 31, 2022): 121–48. http://dx.doi.org/10.37394/232023.2022.2.14.

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Quantum chemistry, condensed matter physics and applied information theory methods are used to reveal the relationship between the molecular structure of radiation injury modifiers and their radioprotective activity in the series of aminothiols and their analogues. Significant electronic and informational parameters of molecules, which are associated with the radioprotective effect of drugs, were determined by statistical analysis methods. Based on the identified significant molecular parameters, possible mechanisms of the biochemical and biophysical radioprotective action of the analyzed chem

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Sharapov, Mars G., Vladimir I. Novoselov, and Sergey V. Gudkov. "Radioprotective Role of Peroxiredoxin 6." Antioxidants 8, no. 1 (2019): 15. http://dx.doi.org/10.3390/antiox8010015.

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Peroxiredoxin 6 (Prdx6) is a member of an evolutionary ancient family of peroxidase enzymes with diverse functions in the cell. Prdx6 is an important enzymatic antioxidant. It reduces a wide range of peroxide substrates in the cell, thus playing a leading role in the maintenance of the redox homeostasis in mammalian cells. Beside peroxidase activity, Prdx6 has been shown to possess an activity of phospholipase A2, an enzyme playing an important role in membrane phospholipid metabolism. Moreover, Prdx6 takes part in intercellular and intracellular signal transduction due to its peroxidase and p

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Vávrová, Jiřina, and M. Řezáčová. "Importance of Proapoptotic Protein PUMA in Cell Radioresistance." Folia Biologica 60, no. 2 (2014): 53–56. http://dx.doi.org/10.14712/fb2014060020053.

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Protein p53 plays an essential role in the induction of apoptosis by ionizing radiation in haemopoietic cells, the damage of which is the main reason for the development of bone marrow post-irradiation syndrome. p53 activation leads to an increase in the Bcl-2 family pro-apoptotic protein PUMA level. PUMA inhibits all the five anti-apoptotic proteins (Mcl-1, Bcl-2, Bcl-XL, Bcl-W and A1) and directly triggers apoptosis mediated by pro-apoptotic proteins Bax/Bak. In proliferating cells, knockout of p53 inhibits apoptosis on the one hand, but on the other disables the cellular division arrest mod

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Ali Al Saidi, Abdullah Khamis, Adibehalsadat Ghazanfari, Ahrum Baek, et al. "Ultrasmall cerium oxide nanoparticles as highly sensitive X-ray contrast agents and their antioxidant effect." RSC Advances 14, no. 6 (2024): 3647–58. http://dx.doi.org/10.1039/d3ra08372a.

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Vypova, E. R., P. S. Kuptsova, L. N. Komarova, A. A. Berseneva, D. A. Baldov, and A. A. Kotlyarov. "Study of possible radioprotective properties of deanol aceglumate under the action of ionizing radiation on human cells." "Radiation and Risk" Bulletin of the National Radiation and Epidemiological Registry 32, no. 3 (2023): 38–49. http://dx.doi.org/10.21870/0131-3878-2023-32-3-38-49.

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One of the effective methods to mitigate late side effects of radiotherapy is to use radioprotectors that reduce harmful effects of ionizing radiation on living cells. Nowadays there are no ideal and multifunctional radioprotectors. In this connection, the research priority is the search for new radioprotectors able to protect healthy cells from side effects of radiation therapy. A promising compound that can be used as a radioprotector is deanol aceglumate. Deanol aceglumate is known as a low-toxic nootropic drug. In addition, there is evidence of its hepatoprotective and antioxidant activity

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Siteni, Silvia, Summer Barron, Krishna Luitel, and Jerry W. Shay. "Radioprotective effect of the anti-diabetic drug metformin." PLOS ONE 19, no. 7 (2024): e0307598. http://dx.doi.org/10.1371/journal.pone.0307598.

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Metformin is a biguanide currently used in the treatment of diabetes mellitus type 2. Besides its anti-glycemic effects, metformin has been reported to induce different cellular pleiotropic effects, depending on concentration and time of treatment. Here we report one administration of metformin (0.5 mM) has radioprotective effects in vitro on BJ human fibroblasts, increasing DNA damage repair and increasing SOD1 expression in the nucleus. Importantly, metformin (200 mg/kg) pre-administration for only 3 days in wild type 129/sv mice, decreases the formation of micronuclei in bone marrow cells a

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Mahran, Yasmen F., Ebtehal El-Demerdash, Ahmed S. Nada, Azza A. Ali, and Ashraf B. Abdel-Naim. "Insights into the Protective Mechanisms of Tamoxifen in Radiotherapy-Induced Ovarian Follicular Loss: Impact on Insulin-Like Growth Factor 1." Endocrinology 154, no. 10 (2013): 3888–99. http://dx.doi.org/10.1210/en.2013-1214.

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Radiotherapy is one of the most common and effective cancer treatments. However, it has a profound impact on ovarian function, leading to premature ovarian failure. With the hope of preserving fertility in cancer survivors, the need for an effective radioprotective therapy is evident. The present study investigated the mechanism of the potential radioprotective effect of tamoxifen (TAM) on γ-irradiation-induced ovarian failure on experimental rats and the impact of the IGF-1 in the underlying protective mechanisms. Female Sprague Dawley rats were either exposed to single whole-body irradiation

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