Littérature scientifique sur le sujet « Raththa kothippu »

Background: Siddha system of medicine depends largely on herbal for the treatment of diseases which was practiced at village levels and now becomes an important medicine in worldwide, According to the Akasthiyar -2000-Part– III textbook, Saaranai Chooranam is a herbal drug that is indicated for Raththa kothippu (Systemic Hypertension) Saaranai is the Tamil name for Trianthema portulacastrum, which belongs to the family Aizoaceae. Aim & Objective: This study primarily aims to evaluate the Physicochemical and Phytochemical evaluation of Saaranai Chooranam, Preliminary Phytochemical analysis such as High Performed Thin Layered Chromatography and Powder Microscopy of Saaranai Chooranam. Methodology: The Physicochemical analysis of Saaranai Chooranam is carried out using standard procedures. Results: Preliminary Phytochemical screening found, the presence of phytochemicals such as Proteins, Terpenoids, Alkaloids, Carbohydrates, and Tannins. High-performance thin-layer chromatography fingerprinting revealed the presence of many phytochemicals with different Rf values and densitometric scans of the plates showed numerous bands and peaks. The Powder Microscopy reveals the presence ofTracheidal fibre, Vessel with bordered pits, Calcium oxalate crystal, Stone cell, Group of sclereids with brownish content, Paracytic stomata and surrounding subsidiary cells, Rosette Calcium oxalate crystal, Sclereid with narrow lumen, Thick walled cells, Tracheidal fibre and Trichome. Physicochemical analysis revealed the values of total ash (17.86%), acid-insoluble ash (1.34%), water-soluble ash (13.62), sulphated ash (25.72%), pH (6.05 in 4% alcohol solution), volatile oil (0.5%), foaming index (111.11%) and swelling index (4ml). Conclusion: This study is an effort to explore the different Physico and Phytochemical compounds of Saaranai Chooranam effective in the management of Raththa kothippu (Systemic hypertension).

In worldwide Siddha system of medicine nowadays become most important medicine, it has fewer side effects in chronic usage. Therefore, in medicines of Siddha system should emphasis their Indications, Contraindications and cautions. The trial drug Saaranai chooranam has been mentioned in siddha literature of “Agasthiyar erandayiram – Part-III” for the management of Raththa kothippu (Systemic hypertension). Primary objective of study to evaluate the Hypolipidemic activity of saaranai chooranamagainst atherogenic diet induced hyperlipidemia in experimental rats. This Observational in vivo study carried out Arulmigu Kalasalingam College of Pharmacy, Tamil Nadu, India. The trial drug contains equal ratio of Saaranai Root and Inthuppu, with adjuvant Ghee or Jagarry. All animals starved for 18 hours and provided water ad libitumbefore the experiment. The animals were divided into five groups of six rats each. Group I served as normal control administered with 2% Carboxy Methyl Cellulose only, Group II served as hyperlipidemic control rats received atherogenic diet, Group III and IV served as test groups received Saaranai Chooranam 200mg/kg and Saaranai Chooranam 400mg/kg respectively. Group V served as Atorvastatin (10mg/kg/day) considered as standard. All the groups except the normal control group administered received atherogenic diet After inducing the hyperlipidemia, the respective treatment was continued for 7 days. Animals were given standard pellet diet and water ad libitum. The next day after the completion of experimental study, the blood was taken from the rats, Liver lipid extraction, Biochemical analysis, Histopathology. The data were statistically analyzed by one-way ANOVA followed by Dennett’s t-test, and value P < 0.05 was considered to be significant. The results obtained from the pharmacological screening have led to the conclusions that, Saaranai chooranam has significant antihyperlipidemic activity. Hence it can be exploited as antihyperlipidemic therapeutic agent or adjuvant in existing therapy for the treatment of hyperlipidemia. Keywords: Saaranai chooranam, Raththa kothippu, Hyperlipidemia, Akasthiyar erandayirum.