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1

BARGHOUTI, NASER S., and GAIL E. KAISER. "SCALING UP RULE-BASED SOFTWARE DEVELOPMENT ENVIRONMENTS." International Journal of Software Engineering and Knowledge Engineering 02, no. 01 (1992): 59–78. http://dx.doi.org/10.1142/s021819409200004x.

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Rule-based software development environments (RBDEs) model the software development process in terms of rules that encapsulate development activities, and assist in executing the process via forward and backward chaining over the rule base. We investigate the scaling up of RBDEs to support (1) multiple views of the rule base for multiple users and (2) evolution of the rule base over the lifetime of a project. Our approach is based on clarifying two distinct functions of rules and chaining: maintaining consistency and automation. By definition, consistency is mandatory whereas automation is not
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Brindha, Subbaian, Takahiro Yoshizue, Rawiwan Wongnak, et al. "An Escherichia coli Expressed Multi-Disulfide Bonded SARS-CoV-2 RBD Shows Native-like Biophysical Properties and Elicits Neutralizing Antisera in a Mouse Model." International Journal of Molecular Sciences 23, no. 24 (2022): 15744. http://dx.doi.org/10.3390/ijms232415744.

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A large-scale Escherichia coli (E. coli) production of the receptor-binding domain (RBD) of the SARS-CoV-2 could yield a versatile and low-cost antigen for a subunit vaccine. Appropriately folded antigens can potentially elicit the production of neutralizing antisera providing immune protection against the virus. However, E. coli expression using a standard protocol produces RBDs with aberrant disulfide bonds among the RBD’s eight cysteines resulting in the expression of insoluble and non-native RBDs. Here, we evaluate whether E. coli expressing RBD can be used as an antigen candidate for a su
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Bouhadou, Siham, Astrid Hilbert, and Youssef Ouknine. "RBSDEs with optional barriers: monotone approximation." Probability, Uncertainty and Quantitative Risk 7, no. 2 (2022): 67–84. http://dx.doi.org/10.3934/puqr.2022005.

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Westerman, Maxwell P., Arnold Pizzey, Jocelyn Hirshman, et al. "Hydroxyurea Treated Sickle Disorders Demonstrate Decreased Plasma Hb, Red Cell Vesicles and Thrombolysis." Blood 106, no. 11 (2005): 2322. http://dx.doi.org/10.1182/blood.v106.11.2322.2322.

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Abstract Free plasma Hb has been recently implicated in the genesis of pulmonary hypertension in sickle cell disorders (SCD) through a putative NO scavenging mechanism. We have recently reported that free plasma Hb is correlated with increased plasma red cell derived vesicles (RBVes) in sickle cell and thalassemia disorders (Westerman, Blood2004; 104:1671). Since high levels of HbF have been associated with decreased elevation of RBVes in children with SCD (Setty Blood2000;96:1119–1124), we hypothesized that patients treated with hydroxyurea (HU) might show a similar normalisation of RBVes. Gi
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Gana, Bukar Abba, Isah Funtua Abdulkadir, Hassan Musa, and Tijjani Garba. "A Conceptual Framework for Organisation of River Basin Developmentand Management in Nigeria." European Journal of Engineering Research and Science 4, no. 6 (2019): 34–40. http://dx.doi.org/10.24018/ejers.2019.4.6.1308.

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River Basin Development Authorities (RBDAs) in Nigeria were established since 1976 and they operate mechanized and capital intensive programmes. All the 12 RBDAs operate as separate Authorities, each with separate administrative and operational autonomy, but sharing the Basin Resources of the 8 Hydrological Areas. However, their performance was generally described as disappointing. This study first reviewed the existing organization of the 12 RBDAs in Nigeria. Thereafter, one of the 8 Hydrological Areas – the Komadugu-Yobe Basin (KYB) – which is the major inland drainage system in Nigeria was
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Gana, Bukar Abba, Isah Funtua Abdulkadir, Hassan Musa, and Tijjani Garba. "Conceptual Framework for Organisation of River Basin Developmentand Management in Nigeria." European Journal of Engineering and Technology Research 4, no. 6 (2019): 34–40. http://dx.doi.org/10.24018/ejeng.2019.4.6.1308.

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River Basin Development Authorities (RBDAs) in Nigeria were established since 1976 and they operate mechanized and capital intensive programmes. All the 12 RBDAs operate as separate Authorities, each with separate administrative and operational autonomy, but sharing the Basin Resources of the 8 Hydrological Areas. However, their performance was generally described as disappointing. This study first reviewed the existing organization of the 12 RBDAs in Nigeria. Thereafter, one of the 8 Hydrological Areas – the Komadugu-Yobe Basin (KYB) – which is the major inland drainage system in Nigeria was
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Hua, Weiwei, Long Jiang, and Xuejun Shi. "Infinite time interval RBSDEs with non-Lipschitz coefficients." Journal of the Korean Statistical Society 42, no. 2 (2013): 247–56. http://dx.doi.org/10.1016/j.jkss.2012.08.005.

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Khan, Sara, Faiza Amin, Rafat Amin, and Naresh Kumar. "Exploring the Effect of Cetylpyridinium Chloride Addition on the Antibacterial Activity and Surface Hardness of Resin-Based Dental Composites." Polymers 16, no. 5 (2024): 588. http://dx.doi.org/10.3390/polym16050588.

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The aim of this study was to evaluate the effect of cetylpyridinium chloride (CPC) addition on the antibacterial and surface hardness characteristics of two commercial resin-based dental composites (RBDCs). A total of two hundred and seventy (n = 270) specimens from Filtek Z250 Universal and Filtek Z350 XT flowable RBDCs were fabricated with the addition of CPC at 2 %wt and 4 %wt concentrations to assess their antibacterial activity using the agar diffusion test and direct contact inhibition test, and their surface hardness using the Vickers microhardness test after 1 day, 30 days, and 90 days
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Khasanova, Diana M., Zuleykha A. Zalyalova, Guzal R. Ilina, and Nailya I. Bagdanova. "Rapid eye movement sleep behavior disorder: modern concept and Parkinson’s disease correlation." Annals of Clinical and Experimental Neurology 18, no. 2 (2024): 62–69. http://dx.doi.org/10.17816/acen.980.

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This review describes the association between rapid eye movement (REM) sleep behavior disorder (RBD) and synucleinopathies, primarily Parkinson's disease. This article reviews the diagnostic criteria, the epidemiology of RBDs, their pathogenesis, and their association with early non-motor symptoms. The data are presented to assess the risk of phenoconversion of RBDs to Parkinson's disease or other synucleinopathies such as Lewy body dementia and multiple system atrophy. A prodromal period of RBDs may precede synucleinopathies years or decades before potential manifestation of motor, cognitive,
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Zhu, Renwei, Sha Tan, Yayi Wang, Linwei Zhang, and Liang Huang. "Physicochemical Properties and Hypolipidemic Activity of Dietary Fiber from Rice Bran Meal Obtained by Three Oil-Production Methods." Foods 12, no. 19 (2023): 3695. http://dx.doi.org/10.3390/foods12193695.

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This study investigated the effects of three oil production methods on the physicochemical properties of dietary fiber from rice bran flour, and the hypolipidemic effects of the dietary fibers were investigated in vitro and in vivo. The particle size results showed that the organic-solvent-impregnated rice bran meal dietary fiber (N-RBDF) had the smallest average particle size and the aqueous enzymatic rice bran meal dietary fiber (E-RBDF) had the narrowest particle size distribution. Scanning electron microscopy (SEM) results demonstrated that all three kinds of rice bran meal dietary fibers
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Tan, Enqing, Erica Frew, Jeff Cooper, et al. "Use of Lateral Flow Immunoassay to Characterize SARS-CoV-2 RBD-Specific Antibodies and Their Ability to React with the UK, SA and BR P.1 Variant RBDs." Diagnostics 11, no. 7 (2021): 1190. http://dx.doi.org/10.3390/diagnostics11071190.

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Identifying anti-spike antibodies that exhibit strong neutralizing activity against current dominant circulating variants, and antibodies that are escaped by these variants, has important implications in the development of therapeutic and diagnostic solutions and in improving understanding of the humoral response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We characterized seven anti-SARS-CoV-2 receptor binding domain (RBD) antibodies for binding activity, pairing capability, and neutralization activity to SARS-CoV-2 and three variant RBDs via lateral flow immuno
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Jing, Yuanyuan, and Zhi Li. "Averaging Principle for Backward Stochastic Differential Equations." Discrete Dynamics in Nature and Society 2021 (March 4, 2021): 1–10. http://dx.doi.org/10.1155/2021/6615989.

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The averaging principle for BSDEs and one-barrier RBSDEs, with Lipschitz coefficients, is investigated. An averaged BSDEs for the original BSDEs is proposed, as well as the one-barrier RBSDEs, and their solutions are quantitatively compared. Under some appropriate assumptions, the solutions to original systems can be approximated by the solutions to averaged stochastic systems in the sense of mean square.
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Ginting, Mimpin, Jamaran Kaban, Herlince Sihotang, and Hendri Tobing. "Pengaruh Suhu Interesterifikasi RBDPO/RBDPS Terhadap Komposisi Trigliserida dan Nilai Kandungan Lemak Padat dalam Pembuatan Lemak Margarin." Talenta Conference Series: Science and Technology (ST) 2, no. 1 (2019): 15–21. http://dx.doi.org/10.32734/st.v2i1.306.

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Pembuatan lemak margarin melalui interesterifikasi dalam industri merupakan suatu proses yang dapat digunakan menggantikan proses blendingan dan hidrogenasi. Salah satu faktor yang mempengaruhi proses interesterifikasi adalah suhu pemanasan. Dalam penelitian ini dilakukan pembuatan lemak margarin melalui proses interesterifikasi dari bahan dasar berbasis minyak kelapa sawit yaitu RBDPO dan RBDPS menggunakan katalis NaOCH 3 dan ingin diketahui pengaruh suhu proses interesterifikasi terhadap nilai kandungan lemak padat (SFC) dan komposisi trigliserida dari variasi suhu pada temperatur 70, 90, 11
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San´e, Ibrahima, Cl´ement Manga, and Sadibou Aidara. "Averaging Principle for BSDEs and one Barrier Reflected BSDEs With Non-Liphschitz Coefficients." Journal of Mathematics Research 16, no. 2 (2024): 62. http://dx.doi.org/10.5539/jmr.v16n2p62.

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In this paper, the averaging principle for BSDEs and one barrier RBSDEs, with non Lipschitz coefficients, is investigated. An averaged BSDEs for the original BSDEs is proposed, as well as the one barrier RBSDEs, and their solutions are quantitatively compared. Under some appropriate assumptions, the solutions to original systems can be approximated by the solutions to averaged stochastic systems in the sense of mean square.
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Aljabry, Mansour S., Fahad Alabbas, Ghaleb Elyamany, et al. "Clinicopathological Features of Rare Bleeding Disorders in High Consanguinity Population; A Retrospective Analysis from Two Tertiary Hospitals in Saudi Arabia." Journal of Applied Hematology 14, no. 2 (2023): 101–7. http://dx.doi.org/10.4103/joah.joah_103_22.

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BACKGROUND: Rare bleeding disorder (RBDs) encompasses a deficiency of one or more of FXIII, FXI, FX, FVII, FV, FII, and FI clotting factors, leading to bleeding disorders with variable presentations and outcomes ranging from none or minimal to life-threatening events. RBDs are still underdiagnosed and underreported, especially in Saudi population with a high prevalence of consanguinity. OBJECTIVES: The study aimed to determine the frequency of RBDs, grading of their bleeding severity, and assessment of clinical manifestations and management of RBDs in tertiary Saudi Arabian hospitals. DESIGN A
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Sen, Ankita, Prakas K. Mandal, Sumit Mitra, et al. "An account of congenital rare bleeding disorders: a systematic study from a tertiary care centre in Eastern India." International Journal of Advances in Medicine 7, no. 7 (2020): 1131. http://dx.doi.org/10.18203/2349-3933.ijam20202589.

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Background: Rarity of rare bleeding disorders (RBDs) is attributed to very low incidence based on ethnicity, distribution and complexity of diagnostic tools. There is scarcity of data on RBDs from Eastern India. This study aims to understand the distribution of RBDs in this region for better patient care.Methods: Retrospective study conducted on patients presented with symptoms/signs of bleeding from January 2018 to December 2019 (two years). Patients having bleeding manifestations from causes other than inherited coagulation disorders, IPDs, and vWD were included. Complete haemogram, peripher
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Burd, C. G., E. L. Matunis, and G. Dreyfuss. "The multiple RNA-binding domains of the mRNA poly(A)-binding protein have different RNA-binding activities." Molecular and Cellular Biology 11, no. 7 (1991): 3419–24. http://dx.doi.org/10.1128/mcb.11.7.3419-3424.1991.

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The poly(A)-binding protein (PABP) is the major mRNA-binding protein in eukaryotes, and it is essential for viability of the yeast Saccharomyces cerevisiae. The amino acid sequence of the protein indicates that it consists of four ribonucleoprotein consensus sequence-containing RNA-binding domains (RBDs I, II, III, and IV) and a proline-rich auxiliary domain at the carboxyl terminus. We produced different parts of the S. cerevisiae PABP and studied their binding to poly(A) and other ribohomopolymers in vitro. We found that none of the individual RBDs of the protein bind poly(A) specifically or
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Burd, C. G., E. L. Matunis, and G. Dreyfuss. "The multiple RNA-binding domains of the mRNA poly(A)-binding protein have different RNA-binding activities." Molecular and Cellular Biology 11, no. 7 (1991): 3419–24. http://dx.doi.org/10.1128/mcb.11.7.3419.

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The poly(A)-binding protein (PABP) is the major mRNA-binding protein in eukaryotes, and it is essential for viability of the yeast Saccharomyces cerevisiae. The amino acid sequence of the protein indicates that it consists of four ribonucleoprotein consensus sequence-containing RNA-binding domains (RBDs I, II, III, and IV) and a proline-rich auxiliary domain at the carboxyl terminus. We produced different parts of the S. cerevisiae PABP and studied their binding to poly(A) and other ribohomopolymers in vitro. We found that none of the individual RBDs of the protein bind poly(A) specifically or
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19

Şalcıoğlu, Zafer, Cengiz Bayram, Hülya Şen, et al. "Congenital Factor Deficiencies in Children: A Report of a Single-Center Experience." Clinical and Applied Thrombosis/Hemostasis 24, no. 6 (2017): 901–7. http://dx.doi.org/10.1177/1076029617731596.

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Congenital factor deficiencies (CFDs) refer to inherited deficiency of coagulation factors in the blood. A total of 481 patients with CFDs, who were diagnosed and followed at our Pediatric Hematology and Oncology Clinic between 1990 and 2015, were retrospectively evaluated. Of the 481 cases, 134 (27.8%) were hemophilia A, 38 (7.9%) were hemophilia B, 57 (11.8%) were von Willebrand disease (vWD), and 252 (52.3%) were rare bleeding disorders (RBDs). The median age of the patients at the time of diagnosis and at the time of the study was 4.1 years (range: 2 months to 20.4 years) and 13.4 years (r
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Qasemi, Ali, Milad Lagzian, Fateh Rahimi, Foad Khosravani Majd, and Zeynab Bayat. "The Power of Probiotics to Combat Urinary Tract Infections: A Comprehensive Review." Research in Biotechnology and Environmental Science 2, no. 1 (2023): 01–11. http://dx.doi.org/10.58803/rbes.2023.2.1.01.

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Urinary tract infections (UTIs) are among the most common bacterial infections and can cause significant morbidity, particularly in women. Recurrent UTIs are a significant clinical problem, and current prophylactic measures, such as antibiotics, are associated with side effects and the risk of antimicrobial resistance. Probiotics, defined as live microorganisms that confer health benefits to the host, have emerged as a potential alternative to traditional treatments for recurrent UTIs. Probiotics can act by modulating the host's immune system, competitively excluding uropathogens, and producin
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Sadr, Soheil, Pouria Ahmadi Simab, and Hassan Borji. "CRISPR-Cas9 as a Potential Cancer Therapy Agent: An Updat." Research in Biotechnology and Environmental Science 2, no. 1 (2023): 12–17. http://dx.doi.org/10.58803/rbes.2023.2.1.02.

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Cancer is the second leading cause of death globally and remains a major economic and social burden. Although our understanding of cancer at the molecular level continues to improve, more effort is needed to develop new therapeutic tools and approaches exploiting these advances. Due to its high efficiency and accuracy, the CRISPR-Cas9 genome editing technique has recently emerged as a cancer treatment strategy. Among its many applications, CRISPR-Cas9 has shown an unprecedented clinical potential to discover novel targets for cancer therapy and to dissect chemical-genetic interactions, providi
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Sahebi, Reza, Nazanin Akbari, Zeynab Bayat, Mohammad Rashidmayvan, Amin Mansoori, and Maria Beihaghi. "A Summary of Autophagy Mechanisms in Cancer Cells." Research in Biotechnology and Environmental Science 1, no. 1 (2022): 28–35. http://dx.doi.org/10.58803/rbes.2022.1.1.06.

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Autophagy is a well-known vital process in cells and plays a significant role in biological evolution, the immune system, and cell death. It can be effective in fatal disorders, such as nervous system degeneration, autoimmune diseases, and cancer. Autophagy has a dual role; on the one hand, it increases cell survival, and on the other hand, it causes cell death in advanced stages although no agreement has yet been accomplished on the role of autophagy in cellular processes. There is evidence that autophagic signaling regulation is inversely related to oncogenic signaling. Numerous commonly act
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REN, YONG, and XILIANG FAN. "REFLECTED BACKWARD STOCHASTIC DIFFERENTIAL EQUATIONS DRIVEN BY A LÉVY PROCESS." ANZIAM Journal 50, no. 4 (2009): 486–500. http://dx.doi.org/10.1017/s1446181109000303.

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AbstractIn this paper, we deal with a class of reflected backward stochastic differential equations (RBSDEs) corresponding to the subdifferential operator of a lower semi-continuous convex function, driven by Teugels martingales associated with a Lévy process. We show the existence and uniqueness of the solution for RBSDEs by means of the penalization method. As an application, we give a probabilistic interpretation for the solutions of a class of partial differential-integral inclusions.
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Park, Jaeil, Dongjin Kim, Gyeonghyun Kim, Jongkwon Lim, and Minjaee Lee. "The Case Study on Performance Measurement Weighting for Efficient Value Engineering Study of Sewage Treatment Facliity." Korean Journal of Construction Engineering and Management 17, no. 3 (2016): 125–33. http://dx.doi.org/10.6106/kjcem.2016.17.3.125.

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Brenner, David J., and Marco Zaider. "Estimating RBEs at clinical doses from microdosimetric spectra." Medical Physics 25, no. 6 (1998): 1055–57. http://dx.doi.org/10.1118/1.598278.

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Muleya, Victor, and Claudius Marondedze. "Functional Roles of RNA-Binding Proteins in Plant Signaling." Life 10, no. 11 (2020): 288. http://dx.doi.org/10.3390/life10110288.

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RNA-binding proteins (RBPs) are typical proteins that bind RNA through single or multiple RNA-binding domains (RBDs). These proteins have a functional role in determining the fate or function of the bound RNAs. A few hundred RBPs were known through in silico prediction based on computational assignment informed by structural similarity and the presence of classical RBDs. However, RBPs lacking such conventional RBDs were omitted. Owing to the recent mRNA interactome capture technology based on UV-crosslinking and fixing proteins to their mRNA targets followed by affinity capture purification an
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Nippatlapalli, Narasamma, and Ligy Philip. "Assessment of novel rotating bipolar multiple disc electrode electrocoagulation–flotation and pulsed plasma corona discharge for the treatment of textile dyes." Water Science and Technology 81, no. 3 (2020): 564–70. http://dx.doi.org/10.2166/wst.2020.137.

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Abstract The current study evaluates the performance of the designed novel electrolytic reactor with rotating bipolar multiple disc electrode (RBDE) in the electrocoagulation–flotation (EC-F) process and a pulsed plasma reactor for the removal of toxic textile dyes. Two different classes of dyes, Methyl Orange (MO), an azo group of dye, and Reactive Blue 19 (RB19), a reactive group of dye, were selected. Efficient removal of both the dyes at a faster rate was obtained with the designed RBDE reactor compared to the EC-F process with static electrodes. RB19 and MO were completely decolourized (1
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Lestari, Puji, Faisal Yusuf, and Mainal Furqan. "Iodine value analysis on RBD palm olein and RBD palm stearin." Journal of Midwifery and Nursing 7, no. 1 (2025): 79–83. https://doi.org/10.35335/jmn.v7i1.5927.

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Studies and analyses were made to determine the degree of uncertainty in the iodine value estimation of refined, bleached, and deodorized (RBD) palm oil and after fractination (RBD palm olein and RBD palm stearin). At refining process and produce Refined Bleached Deodorized Palm Oil (RBDPO), enter the fractionation process will produce RBD palm olein (RBDPL) and RBD palm stearin (RBDPS). A commonly used metric to assess the quality of vegetable oils is the iodine value (IV). The main objective is to observe IV of RBDPL and RBDPS after fractination process. The approved AOCS Cd 1–25 technique w
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Jańczak-Borkowska, Katarzyna. "Generalized RBSDEs with Random Terminal Time and Applications to PDEs." Bulletin of the Polish Academy of Sciences Mathematics 59, no. 1 (2011): 85–100. http://dx.doi.org/10.4064/ba59-1-10.

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Palla, Roberta, Flora Peyvandi, and Amy D. Shapiro. "Rare bleeding disorders: diagnosis and treatment." Blood 125, no. 13 (2015): 2052–61. http://dx.doi.org/10.1182/blood-2014-08-532820.

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Abstract Despite the worldwide prevalence of rare bleeding disorders (RBDs), knowledge of these conditions and their management is suboptimal; health care professionals often have little diagnostic and treatment experience with variable access to diagnostic modalities required for accurate identification. Therefore, patients often experience morbidity and mortality due to delayed diagnosis. As RBDs represent a small potential commercial market, few, if any, specific therapies exist for these conditions. As a result, affected individuals commonly face delayed diagnosis, incomplete laboratory ev
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Sapam, Sobita, and Bikas Kumar Sinha. "Analysis of Mixed Effects Model for Randomized Block Designs with Both-sided Neighbor-Effects." International Journal of Statistical Sciences 23, no. 2 (2023): 19–30. http://dx.doi.org/10.3329/ijss.v23i2.70128.

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In this study we confine our attention to Randomized Block Designs (RBDs) with random block effects in the presence of both-sided neighbor-effects and focus our attention to (i) estimation of variance components, and (ii) estimation of treatment contrasts as well as both left-sided and right sided neighbor-effects contrasts. We start with a simple set-up of 4 blocks and 4 treatments in an RBD. This we do by concurrently studying three distinct RBDs with the same parameters. However, the allocations of Left Neighbor (LN)- and Right Neighbor (RN)-Effects are assumed to be different across the RB
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Roanes-Lozano, Eugenio, Eduardo A. Casella, Fernando Sánchez, and Antonio Hernando. "Diagnosis in Tennis Serving Technique." Algorithms 13, no. 5 (2020): 106. http://dx.doi.org/10.3390/a13050106.

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Tennis is a sport with a very complex technique. Amateur tennis players have trainers and/or coaches, but are not usually accompanied by them to championships. Curiously, in this sport, the result of many matches can be changed by a small hint like ‘hit the ball a little higher when serving’. However, the biomechanical of a tennis stroke is only clear to an expert. We, therefore, developed a prototype of a rule-based expert system (RBES) aimed at an amateur competition player that is not accompanied by his/her coach to a championship and is not serving as usual (the RBES is so far restricted t
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Brasil, Lourdes M., Jean C. C. Rojas, Fernando M. de Azevedo, and Carlos W. D. de Almeida. "Hybrid Module of the IACVIRTUAL Project." Journal of Advanced Computational Intelligence and Intelligent Informatics 10, no. 4 (2006): 472–76. http://dx.doi.org/10.20965/jaciii.2006.p0472.

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This work represents the hybrid module of the IACVIRTUAL meta-environment. In this context we will basically approach the Hybrid Expert System (HES), which is composed by the Neural Networks Based Expert System (NNES) and by the Rule-Based Expert System (RBES). The HES is destined to support the decision of a clinical-surgical team, in the area of cardiology, in the definition of a therapeutic conduct in patients with coronary heart disease. The implementation process starts with the Knowledge Acquisition (KA), which comes from the analysis of a series of clinical parameters, which are used as
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Schwob, P. R. "An in-receiver database-the critical factor in RBDS." IEEE Transactions on Consumer Electronics 39, no. 3 (1993): 442–47. http://dx.doi.org/10.1109/30.234618.

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Roanes-Lozano, Eugenio, José Luis Galán-García, and Gabriel Aguilera-Venegas. "A prototype of a RBES for personalized menus generation." Applied Mathematics and Computation 315 (December 2017): 615–24. http://dx.doi.org/10.1016/j.amc.2016.12.023.

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Shamoo, Yousif, Norzehan Abdul-Manan, and Kenneth R. Williams. "Multiple RNA binding domains (RBDs) just don't add up." Nucleic Acids Research 23, no. 5 (1995): 725–28. http://dx.doi.org/10.1093/nar/23.5.725.

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Iriani, Yulidia, Yan Ramona, and Ni Putu Adriani Astiti. "Potensi Ekstrak Ethanol Daun Salam Dan Air Rebusan Daun Salam Untuk Memperbaiki Profil Lipid (Ldl-Kolesterol) Darah Pada Tikus Wistar." Metamorfosa: Journal of Biological Sciences 8, no. 1 (2021): 89. http://dx.doi.org/10.24843/metamorfosa.2021.v08.i01.p09.

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Hyperlipidimia merupakan suatu penyakit/kelainan terkait kardiovascular yang banyak dijumpai, dan jumlah penderitanya cenderung mengalami peningkatan. Kelainan ini disebabkan oleh pola makan masyarakat yang cenderung mengkonsumsi makanan tinggi lemak, tetapi rendah kadar serat. Pemakaian obat paten, seperti simvastatin merupakan pilihan utama saat ini untuk mengatasi masalah tersebut. Namun, pemakaian obat ini dalam waktu lama tidak dianjurkan, sehingga perlu dicari bahan alam yang mempunyai efek sama dengan obat tersebut. Pada penelitian ini, daun salam (Sizygium polyanthum [Wight] Walp) diuj
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Karimi, Mehran, Hassan Mohtadi, Sezaneh Haghpanah, and Mahboobeh Akbari. "Quality of Life in Children with Rare Bleeding Disorders." Blood 126, no. 23 (2015): 4698. http://dx.doi.org/10.1182/blood.v126.23.4698.4698.

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Abstract Background: Patients with rare bleeding disorders (RBDs) face with several problems due to the chronic feature of the disease. So their physical and mental health is affected. Objective: The aim of this study is to evaluate quality of life (QOL) in patients with RBDs using haemo-QOL questionnaire. Methods: In this cross-sectional study, 52 consecutive children aged between4-18 years old with RBDs registered at the Haemophila center of Fars province in Southern Iran were investigated from January to April 2015. Quality of life was evaluated by expert nurses using haemo-QOL questionnair
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Mustafa, Mansoor, and Muhammad Omer Farooq Malik. "Factors Hindering Solar Photovoltaic System Implementation in Buildings and Infrastructure Projects: Analysis through a Multiple Linear Regression Model and Rule-Based Decision Support System." Buildings 13, no. 7 (2023): 1786. http://dx.doi.org/10.3390/buildings13071786.

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Energy plays a predominant role in the development of society. With advancements in technology and the growth of society (buildings and infrastructures), the demand for energy is rapidly increasing. Developing countries typically rely on the import of fossil fuels and capital investments in infrastructure development to meet their energy needs. The execution of solar PV projects in developing countries is currently not being implemented promisingly. Therefore, the determination of the critical success factors hindering the implementation of solar PV projects is the need of the hour. The aim of
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Ponomarenko, Tatyana, Marina Nevskaya, and Oksana Marinina. "An Assessment of the Applicability of Sustainability Measurement Tools to Resource-Based Economies of the Commonwealth of Independent States." Sustainability 12, no. 14 (2020): 5582. http://dx.doi.org/10.3390/su12145582.

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The concept of sustainable development (SD) is aimed at ensuring public well-being for the present and future generations. Hundreds of methods have been proposed for assessing and comparing the sustainable development of countries and analyzing their contribution to the future of the world. When applied to resource-based economies (RBEs), assessment tools do not take into account the value and impact of mineral resources on SD indicators. The purpose of the study is to reveal the limitations of applying some tools by taking into consideration the specific features of RBEs. Research methods inc
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Luo, Deyan, Xuechao Liu, Li Xing, et al. "Immunogenicity and Protection from Receptor-Binding Domains of Toxins as Potential Vaccine Candidates for Clostridium difficile." Vaccines 7, no. 4 (2019): 180. http://dx.doi.org/10.3390/vaccines7040180.

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The receptor-binding domains (RBDs) located in toxin A and toxin B of Clostridium difficile are known to be nontoxic and immunogenic. We need to develop a new type vaccine based on RBDs. In this study, we expressed and purified recombinant proteins (named RBD-TcdA and RBD-TcdB) as vaccine candidates containing the RBDs of toxin A and toxin B, respectively, from the C. difficile reference strain VPI10463. The immunogenicity and protection of the vaccine candidates RBD-TcdA, RBD-TcdB, and RBD-TcdA/B was evaluated by ELISA and survival assays. The data indicated that mice immunized with all vacci
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Coart, Elisabeth, Everardo D. Saad, Qian Shi, et al. "Trial-level association between response-based endpoints (RBEs) and progression-free (PFS)/overall survival (OS) in first-line therapy for metastatic colorectal cancer (mCRC) in the ARCAD database." Journal of Clinical Oncology 33, no. 3_suppl (2015): 666. http://dx.doi.org/10.1200/jco.2015.33.3_suppl.666.

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666 Background: Early tumor shrinkage (ETS; ≥20% decrease from baseline) and early objective tumor response (EOTR; CR/PR by RECIST) are associated with improved PFS/OS to a similar extent than best overall response (BOR), confirmed response (ConfR) and non-progression rate (NPR; CR/PR/SD by RECIST) at the individual level in first-line mCRC (ASCO 2014, abstr 3538/3578). We assessed these RBEs at the trial level. Methods: Data were available on 12,185 pts enrolled in a total of 17 randomized trials of chemotherapy (CT) alone or with targeted agents (TAs). ETS, EOTR and NPR were assessed at 6/8/
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Tsamesidis, Ioannis, Evangelia Stalika, Chinedu O. Egwu, et al. "The Potential Impact of Blood System on Dietary Habits and Smoking." Medicines 9, no. 1 (2022): 3. http://dx.doi.org/10.3390/medicines9010003.

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The ‘Blood-Type’ diet advises individuals to eat according to their ABO blood group to improve their health and decrease the risk of chronic diseases. However, the food preferences of individuals with different blood groups have not been examined. The aim of our study was to investigate, in healthy regular blood donors (rBDs), the associations of smoke, alcohol, caffeine, vitamin and fat intake with their different blood groups and if ABO groups could be a potential predictor tool for disease prevention. A total of 329 volunteers were divided into four groups according to their ABO types: Grou
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Chen, Qian-Nan, Bing-Qing Bai, Yan Xu, Qiao Mei, and Xiao-Chang Liu. "Sporadic gastrinoma with refractory benign esophageal stricture: A case report." World Journal of Clinical Cases 12, no. 7 (2024): 1284–89. http://dx.doi.org/10.12998/wjcc.v12.i7.1284.

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BACKGROUND Gastrinoma is characterized by an excessive release of gastrin, leading to hypersecretion of gastric acid, subsequently resulting in recurrent peptic ulcers, chronic diarrhea, and even esophageal strictures. This case report aims to improve awareness and facilitate early diagnosis and treatment of gastrinoma by presenting a rare case of gastrinoma with refractory benign esophageal stricture (RBES). Additionally, it highlights the persistent challenges that gastroenterologists encounter in managing RBES. CASE SUMMARY This case demonstrates a patient with gastrinoma who developed RBES
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Wang, Shouyi. "Comparison of the Suitability between the Piston Solid Gravitational Energy Storage and Rechargeable Battery Energy Storage for Applications in the Industrial Process of Electricity Storage." Highlights in Science, Engineering and Technology 83 (February 27, 2024): 104–12. http://dx.doi.org/10.54097/qxtac480.

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Contemporarily, the electricity deficiency is a problem that should be faced and discussed for most countries. To solve this problem, the electricity should be used wisely. In this paper, the suitability between the Piston Solid Gravitational Energy (PSGES) and Rechargeable Battery Energy Storage (RBES) for applications in the electricity storage for both scenarios is compared. First, the development conditions, quantitative metrics including energy efficiency, energy density, response time of discharging, energy losses during the storage, duration of the storage, and levelized cost of the ene
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Lu, Qing, Tiantian Lei, Hailin Yan, Jinlin Yang, and Hongsheng Ma. "FA07.04: THE ROLE OF ENDOSCOPIC DILATION AND STENTS IN THE REFRACTORY BENIGN ESOPHAGEAL STRICTURES: A RETROSPECTIVE ANALYSIS." Diseases of the Esophagus 31, Supplement_1 (2018): 14. http://dx.doi.org/10.1093/dote/doy089.fa07.04.

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Abstract Background The outcomes of patients with refractory benign esophageal strictures (RBES) was unclear and lacking in relative researches on the clinical efficacy of dilation compared with stent placement. Our objective was to explore the role of endoscopic dilation and stents in the management of RBES. Methods This study including patients with RBES (recurrence of dysphagia despite endoscopic therapy more than 3 sessions) by dilation and stents between January 2009 and December 2017. Endoscopic therapy success was defined as: before the end of the follow-up, no need for endoscopic inter
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Wang, Zhengguang, Zhihan Yang, Mami Shishido, et al. "Microcystis viridis NIES-102 Cyanobacteria Lectin (MVL) Interacts with SARS-CoV-2 Spike Protein Receptor Binding Domains (RBDs) via Protein–Protein Interaction." International Journal of Molecular Sciences 25, no. 12 (2024): 6696. http://dx.doi.org/10.3390/ijms25126696.

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The emergence of coronavirus disease 2019 (COVID-19) posed a major challenge to healthcare systems worldwide, especially as mutations in the culprit Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) complicated the development of vaccines and antiviral drugs. Therefore, the search for natural products with broad anti-SARS-CoV-2 capabilities is an important option for the prevention and treatment of similar infectious diseases. Lectins, which are widely recognized as antiviral agents, could contribute to the development of anti-SARS-CoV-2 drugs. This study evaluated the binding affin
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Aksenova, Anna Y., Ilya V. Likhachev, Sergei Y. Grishin, and Oxana V. Galzitskaya. "The Increased Amyloidogenicity of Spike RBD and pH-Dependent Binding to ACE2 May Contribute to the Transmissibility and Pathogenic Properties of SARS-CoV-2 Omicron as Suggested by In Silico Study." International Journal of Molecular Sciences 23, no. 21 (2022): 13502. http://dx.doi.org/10.3390/ijms232113502.

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SARS-CoV-2 is a rapidly evolving pathogen that has caused a global pandemic characterized by several consecutive waves. Based on epidemiological and NGS data, many different variants of SARS-CoV-2 were described and characterized since the original variant emerged in Wuhan in 2019. Notably, SARS-CoV-2 variants differ in transmissibility and pathogenicity in the human population, although the molecular basis for this difference is still debatable. A significant role is attributed to amino acid changes in the binding surface of the Spike protein to the ACE2 receptor, which may facilitate virus e
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Gotor, Nieves Lorenzo, Alexandros Armaos, Giulia Calloni, et al. "RNA-binding and prion domains: the Yin and Yang of phase separation." Nucleic Acids Research 48, no. 17 (2020): 9491–504. http://dx.doi.org/10.1093/nar/gkaa681.

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Abstract Proteins and RNAs assemble in membrane-less organelles that organize intracellular spaces and regulate biochemical reactions. The ability of proteins and RNAs to form condensates is encoded in their sequences, yet it is unknown which domains drive the phase separation (PS) process and what are their specific roles. Here, we systematically investigated the human and yeast proteomes to find regions promoting condensation. Using advanced computational methods to predict the PS propensity of proteins, we designed a set of experiments to investigate the contributions of Prion-Like Domains
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Sun, Qiyue. "Preservation and renewal of historical and cultural blocks under urban RBD model: A case study of Baoding West Street." E3S Web of Conferences 553 (2024): 04006. http://dx.doi.org/10.1051/e3sconf/202455304006.

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Preservation and renewal of historical and cultural blocks is an important part of the urban renewal process. At present, China pays more and more attention to the protection of historical and cultural blocks, how to make historical and cultural blocks revitalized in modern cities is a problem worth thinking about. The urban RBD model provides new ideas for the protection and renewal of historical and cultural blocks. This paper intends to summarize the development and characteristics of the urban RBD model by using the literature research method and the field research method, conduct case stu
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