Thèses sur le sujet « RDC »

<p align="justify">Les Européens (Belges, Grecs et Italiens) du Katanga, dont le nombre s’est considérablement réduit au cours de la période post-coloniale, forment aujourd’hui le groupe le plus puissant de l’économie de la région. Au vu des troubles qui ont marqué l’histoire du Congo depuis l’indépendance, pourquoi sont-ils restés sur place ?Comment ont-ils développé leurs affaires dans une économie sur le déclin, en voie de marginalisation, et dans une structure politique patrimoniale de plus en plus instable ?Et quelle est leur place au sein de la société congolaise ?Telle est la triple question de départ à laquelle tente de répondre cette thèse en abordant de façon successive, au fil des chapitres, leur parcours migratoire, leur insertion dans la société congolaise, la dynamique de leur communauté, leur rôle dans les deux plus gros secteurs de la région, et leurs rapports avec les représentants de l’Etat. Elle prend appui pour ce faire sur une recherche de terrain conduite entre 2003 et 2004.</p><p><p align="justify">If the number of Europeans (Belgians, Greeks and Italians) living in Katanga has considerably decreased during the post-colonial period, they represent today the most powerful entrepreneurial group of the local economy. Once considered the troubles they came across since independence, why did they remain in the Congo? How did they develop their business in a declining economy, in process of marginalization, and in a patrimonial political structure, which proves to be more and more unstable? Finally, what is their place and role in Congolese society? These are the three questions this thesis tries to give an answer. Through the chapters, it studies the migration of expatriates in Africa, their relationship with Congolese society, the dynamics of their community, their role in the two most important sectors of Katanga, and the way they interact with the agents of the State. For this purpose, it rests upon a fieldwork research led between 2003 and 2004.</p><br>Doctorat en sciences sociales, Orientation anthropologie<br>info:eu-repo/semantics/nonPublished

Les Européens (Belges, Grecs et Italiens) du Katanga, dont le nombre s'est considérablement réduit au cours de la période post-coloniale, forment aujourd'hui le groupe le plus puissant de l'économie de la région. Au vu des troubles qui ont marqué l'histoire du Congo depuis l'indépendance, pourquoi sont-ils restés sur place? Comment ont-ils développé leurs affaires dans une économie sur le déclin, en voie de marginalisation, et dans une structure politique patrimoniale de plus en plus instable? Et quelle est leur place au sein de la société congolaise? Telle est la triple question de départ à laquelle tente de répondre cette thèse en abordant de façon successive, au fil des chapitres, leur parcours migratoire, leur insertion dans la société congolaise, la dynamique de leur communauté, leur rôle dans les deux plus gros secteurs de la région, et leurs rapports avec les représentants de l'Etat. Elle prend appui pour ce faire sur une recherche de terrain conduite entre 2003 et 2004<br>If the number of Europeans (Belgians, Greeks and Italians) living in Katanga has considerably decreased during the post-colonial period, they represent today the most powerful entrepreneurial group of the local economy. Once considered the troubles they came across since independence, why did they remain in the Congo? How did they develop their business in a declining economy, in process of marginalization, and in a patrimonial political structure, which proves to be more and more unstable? Finally, what is their place and role in Congolese society? These are the three questions this thesis tries to give an answer. Through the chapters, it studies the migration of expatriates in Africa, their relationship with Congolese society, the dynamics of their community, their role in the two most important sectors of Katanga, and the way they interact with the agents of the State. For this purpose, it rests upon a fieldwork research led between 2003 and 2004

Qu'est-ce que l'intégration? Existe-t-il des personnes intégrées et des personnes non intégrées ou mal intégrées dans la société québécoise? Sur quelles variables pouvons-nous nous baser pour déterminer le niveau d'intégration. Quel est l'impact des politiques d'immigration et d'intégration appliquées par le gouvernement du Québec en vue de promouvoir ou développer et accélérer l'intégration des immigrants d'origine congolaise? Pourquoi le cas des immigrants congolais nécessite-t-il une intervention spéciale de la part de toutes les instances décisionnelles: législatif, financiers et socioculturel? Cette étude tente d'apporter des éléments de réponse à ces questions sur la base d'une enquête qualitative auprès de quelques membres de la communauté congolaise de Montréal.

Orientadores: Walter Esteves e Antonio Jose de Almeida Meirelles<br>Tese (doutorado) - Universidade Estadula de Campinas, Faculdade de Engenharia de Alimentos<br>Made available in DSpace on 2018-07-22T03:12:41Z (GMT). No. of bitstreams: 1 Antoniassi_Rosemar_D.pdf: 7487195 bytes, checksum: ef9bf561ee39adfe81d14ee426420e32 (MD5) Previous issue date: 1996<br>Resumo: O processo contínuo de desacidificação de óleo de milho com etanol foi realizado em um extrator de discos rotativos (RDC), com 74 cm de altura total, 31 cm de altura na região de extração e 5 cm de diâmetro interno. As condições operacionais favoráveis ao processo de desacidificação de óleo de milho no RDC utilizado foram: etanol como fase contínua e óleo como fase dispersa, seis discos na região de extração de 20% de área livre de escoamento, carga total de 40 a 70 gramas/minuto e relação óleo/solvente de 0,5/1 e 1/1. Devido à insolubilização dos fosfatídios no etanol, foi estudado um processo de pré-tratamento do óleo de milho bruto, envolvendo etapas de degomagem e branqueamento. A degomagem do óleo de milho bruto foi conduzida em diversas temperaturas, com agentes de degomagem ácidos, neutros e alcalinos. Maior remoção de fósforo ocorreu na degomagem com água à temperatura de 30°C. Quando a degomagem do óleo de milho bruto foi realizada abaixo de 30°C, independente do agente de degomagem utilizado, ocorreram degomageme winterização simultâneas. O pré-tratamento do óleo de milho bruto com até 400 ppm de fósforo, para alimentação da coluna de discos rotativos, foi realizado através de degomagem com água à temperatura de 30°C. A seguir, o óleo degomado foi tratado com 0,1% de sílica Trysil3000, sob vácuo, às temperaturas de 70 ou 80°C, por 15 minutos, seguido de branqueamento com 1 % de terra branqueadora, à temperatura de 100°C por 30 minutos. O etanol hidratado com 5,83% de água foi selecionado como solvente para o processo contínuo, com base em sua seletividade, coeficiente de distribuição e solubilidade no óleo. O processo de desacidificação do óleo de milho branqueado com conteúdo de ácidos graxos livres de 0,96 a 7,74% e etanol, foi estudado no RDC nas relações alimentação/solvente de 0,5/1 e 1/1, na faixa de temperatura de 24 a 32°C, variando-se a velocidade de agitação até 300 rpm. A eficiência do processo de desacidificação, a fração de ácidos graxos livres e diglicerídios transferida e as perdas de triglicerídios aumentaram com a velocidade de agitação. O aumento da relação óleo/solvente reduziu as perdas de triglicerídios e a transferência de diglicerídios e de ácidos graxos livres. Nas condições utilizadas, ocorreu remoção de até 80% da acidez inicial do óleo. A eficiência do processo foi de até 1,5 estágios de equilíbrio. Os resultados obtidos possibilitaram estabelecer as condições operacionais do RDC na desacidificação de óleo milho com etanol, que se revelou um processo promissor, que se caracteriza pela alta carga processada e alta eficiência.<br>Abstract: Deacidification of com oil with ethanol by a continuous process was conduded in a perforated rotating-disc-contador (RDC). Since the phosphatides are insoluble in ethanol, different pre-treatments were performed such as degumming and bleahing to reduce the phosphorus content. Water degumming of crude com oil was more efficient than acid degumming with citric acid, at different temperatures varying from 10 to 70°C. The degumming of high acidity com oil was more efficient when neutral degumming agents were used. Samples of oils degummed at temperatures of 30°C and below passed the Cold Test (6 hours at O°C), independently of the degumming agents used. Under these conditions, simultaneous degumming and dewaxing occurred. Therefore, a separate winterization is not necessary at these temperatures. Degummed oil was treated with 0.1 % Silica at 70 or 80°C for 15 minutes under vacuum and bleached with 1 % of bleaching earth at 100°C for 30 minutes under vacuum. The bleached oil was used in the liquid-liquid extradion. The experimental operating conditions used in this study were: temperature ¬ 24 to 32°C; rotating speed - up to 300 rpm; feed/solvent ratio - 0.5/1 and 1/1; feed and solvent flow - 20 to 50 grams/min. The specification of the column was: length of 74 cm, diameter of 5 cm and extradion zone height of 31 cm, with 6 disks with free area of 20%. Azeotropic ethanol was chosen based on its seledivity and its capacity to extrad free fatty acid and diglyceride. The free fatty acid content varied from 0.96 to 7.74% and from 0.37 to 4.68%, for bleached and refined oil, respectively. The redudion of free fatty acid and diglyceride contents depended on the feed/solvent ratio and rotation speed. The perforated rotating disc contador was efficient in the deacidification of bleached com oil with a free fatty acid content of up to 7.80%.<br>Doutorado<br>Doutor em Tecnologia de Alimentos

Notre recherche a consisté a nous faire une opinion raisonnée sur les interventions des Institutions de Bretton-Woods en République Démocratique de Congo, en nous appuyant sur une analyse de long terme de l’endettement extérieur du pays, et par conséquent à la mise en œuvre des programmes des stabilisations dans les années 70 et d’ajustement structurel depuis les années 80. Cette analyse nous a permis de mettre en lumière les contraintes économiques et sociales, internes et extérieures, auxquelles le pays a dû faire face. Loin de soulager cette économie rentière, les thérapies de choc préconisées par ces Institutions ont provoqué des coûts ou effets secondaires négatifs, délibérément cherché ou non sur d’autres variables (revenu global, niveau des prix, inflation/hyperinflation…). D’autre part, elles ont eu un coût social élevé, et ont contribuées lourdement à une détérioration de la répartition des revenus entre les diverses couches sociales du pays. L’échec des programmes d’ajustement structurel étant aujourd’hui reconnu, il était devenu donc impératif d’imaginer d’autres types d’approches moins superficielles, qui puissent intégrer non-seulement l’équilibre des variables macro et/ou micro-économiques, mais aussi méso-économique ; et donc l’accent doit être désormais mis sur l’amont (discussions des politiques) et sur l’aval (mis au point des projets ou programmes). C’est ainsi que furent mis en place, depuis le milieu des années 90, les mesures d’allègement ou d’annulation de la dette extérieure. L’austérité préconisée aujourd’hui, face à la crise de la dette dans la zone euro, semble ne pas tenir compte des conséquences que les politiques d’inspiration monétariste ont entraînées partout où elles ont été mises en œuvre, et particulièrement en Afrique. Ainsi, nous-nous demandons si le Libéraux ont-ils retenu les leçons des échecs des programmes d’ajustement structurel (PAS) dans les pays ajustés. Pour ce faire, nous-nous sommes permis de proposer quelques perspectives ou voies de sortie afin d’éviter de retomber dans le cycle de la dette que la RD Congo a connut<br>Our research was to give us a reasoned opinion on the actions of the Bretton-Woods in DR Congo, relying on an analysis of long term external debt of the country, and therefore the implementation of programs stabilization in the 70s and structural adjustment since the 80s. This analysis allowed us to highlight the economic and social constraints, internal and external, that the country faced. Far from alleviating the rentier economy, shock therapies advocated by these institutions have caused costs or negative side effects, deliberately sought or not other variables (total income, inflation/hyperinflation…). On the other hand, they had a high social cost, and contributed heavily to the deterioration of income distribution among different social strata of the country. The failure of structural adjustment programs (SAPs) is regnized today, it has become imperative to imagine other types of less superficial approaches that can integrate not only the balance of macro variables and/or micro-economic, but also meso, and therefore the emphasis should now be placed on the upstream (policy discussion) and downstream (developed projects or programs). Thus were established since the mid 90s, the relief measures or cancellation of the external debt. The austerity advocated today, faced with the debt crisis in the euro area seems to ignore the impact that monetary policies have led to inspiration wherever they have been implemented, particularity in Africa. Thus, we ask whether we Liberals have learned from the failures of adjustment programs (SAPs) in the country originates, the former adjusted. To do this, we have allowed us to propose a few prospects or output channels to avoid failing into the cycle of debt that DR Congo has experienced so far

A l'interface de la sociologie des migrations et de la sociologie politique, la thèse porte sur les migrations de retour des réfugiés congolais à partir des principaux pays d'acceuil l'afrique centrale. loin d'être regardées dans une perspective linéaire et statique entre deux sédentarités mais analysées à partir d'observation in situ et d'entretiens biographiques réalisés pendant près de seize mois dans les espaces d'accueil et de retour, les migrations de retour son intégrées ici dans un espace migratoire dynamique fait d'oppositions et de transactions entre les dispositifs du flux migratoire qui organisent et réglementent les migrations de retour, et les multiples pratiques formelles et informelles du sujet dont les intenses jeux de tension s'inscrivent dans un contexte soutenu de limitation des flux migratoires et l'accroissement de nouvelles formes de mobilité dans l'espace migratoire d'afrique centrale<br>In the interface of the sociology of migration and political sociology, the thesis focuses on return migration of Congolese refugees from the main host countries of central Africa. Far from being observed in a linear and static perspective between two sedentarinesses but analyzed starting from in situ observations and from biographical interviews conducted during 16 months in host and return areas, the migrations of return are integrated in a dynamic migratory space constituted by oppositions and transactions between the biopolitic plans of retention of flows and the circulatory practices of the refugees. The accent is particularly focused on negotiating "biographical crossroads" and migratory careers of refugees from the social, spatial and political capital acquired during the refuge time. How, in these intersections between migratory careers and biopolitical plans, the returnees can define and negotiate their installations in the environment of return ?

La recherche sur la croyance à la sorcellerie d’antan, c’est-à-dire avant la colonisation de l’Afrique subsaharienne. Le savoir de ces données survivait dans la mémoire de certains aînés qui peuvent se rappeler. Nous avons découvert que pour être sorcier (Nkangadoka) chez les Tetela, il faut être initié. On a deux types de sorciers :celui qui vit dans l’anonymat et celui qui se dévoile parce qu’il est à la fois sorcier et devin-thérapeute. Il y a la notion de personne avec les principes spirituels, quatre pour la personne ordinaire, le double, c’est-à-dire 4 x deux, pour le sorcier. Nous avons aussi découvert l’importance que les Tetela apportent à la vie post-morte, donc la réincarnation. La permanence de cette croyance jusqu’aujourd’hui malgré la métamorphose de la société (industrie, médecine, écoles, les églises de réveil…)<br>Doctorat en Philosophie<br>info:eu-repo/semantics/nonPublished

Made available in DSpace on 2011-05-04T12:36:21Z (GMT). No. of bitstreams: 0 Previous issue date: 2010<br>Trata-se de um estudo que analisa as ações do Órgão Regulador daPropaganda de Medicamentos no período de 2005 a 2009. A propaganda é um instrumento de promoção da comercialização de medicamentos e de acordo com a própria Agência Nacional de Vigilância Sanitária (ANVISA) e estudos acadêmicos 90 por cento das peças publicitárias exibidas contêm irregularidades. O setor regulado, representado pelas agências de publicidade, indústria e comércio varejista farmacêutico, atua como um forte agente influenciador sobreas normas. Isso ocorre em detrimento do que é preconizado como uso racionale da Política Nacional de Medicamentos. O trabalho analisa os debates ocorridos na Câmara Setorial de Propaganda de Produtos Sujeitos à Vigilância Sanitária da ANVISA, as proposições dos setores envolvidos na área da propaganda de medicamentos, informações veiculadas pela própria Agência e estudos acadêmicos sobre o setor. O trabalho também analisa as estratégias empregadas pela ANVISA para fiscalização e monitoração do setor, bem como a transparência na construção da Resolução de Diretoria Colegiada (RDC) 96/2008. Durante os quatro anos de discussão da regulação de propaganda de medicamentos no país, a nova RDC 96/2008, assim como as demais ações da ANVISA não conseguiram registrar avanços. Portanto, é preciso que se aprofunde ainda mais o debate no sentido de um maior controle da propaganda de medicamentos no país.<br>This is a study that examines the actions of the Regulatory Agency of Drug Advertising in the period 2005 to 2009. The propaganda is an instrument of promotion of the marketing of medicines and in agreement with the Brazilian’s National Health Surveillance Agency (ANVISA) itself and academic studies 90 % of the publicity pretentious pieces contain irregularities. The regulated sector represented by the agencies of publicity, industry and retail pharmaceutical commerce, influence like a strong Influencer agent over the standards. That takes place to the detriment of what it is extolled like rational use and of the National Politics of Medicines. The work analyses the discussions occurred in the Chamber Setorial of Propaganda of Products Subject to the Sanitary Vigilance of the ANVISA, the propositions of the sectors wrapped in the area of medicines propaganda, informations conveyed by the Agency itself and academic studies on the sector. The work also analyses the strategies employed by the ANVISA for inspection and monitoring of sector, as well as the transparency in the construction of the RDC 96/2008. During the four years of discussion on the regulation of drug advertising in the country, the new Anvisa’s Resolution 96/2008, as well as other actions ANVISA failed to record progress. Thus, it is necessary to deepen further the debate to greater control of drug advertising in the country.

Master of Science<br>Department of Chemical Engineering<br>Larry E. Erickson<br>Caprolactam (C₆H₁₁NO) is produced in industry primarily as a monomer to be converted to nylon-6 via a polymerization reaction. More demanding purity requirements for nylon-6 have increased the performance requirements of extraction columns in the purification train of caprolactam production. Caprolactam is produced by performing a Beckmann Rearrangement on cyclohexanone oxime followed by a neutralization of the excess oleum post reaction. The resulting side product is ammonium sulfate in water with a residual amount of caprolactam that has to be extracted with benzene from the aqueous ammonium sulfate solution to reduce product losses. The aqueous caprolactam liquor is extracted in another column into benzene which purifies the product from water soluble impurities. The resulting caprolactam dissolved in benzene is back extracted into water where the final purification steps are completed prior to storage. Rotating disk contactor (RDC) extraction columns were invented by Royal Dutch Shell in the early 1950’s. The columns have a rotor in the center that is driven by an electric motor to rotate equally spaced flat disks inside the column. There are equally spaced annulus shaped stators that serve to provide mixing-separation compartments for each of the mounted disks on the rotor. Of the variables to consider for the optimum performance of the extraction in the RDC extraction column is the rotor speed. Rotor speed curves are generated for the 3 RDC extraction columns of the caprolactam purification as well as calculations of the number of theoretical stages for each of the columns based on actual performance data. Benzene is the solvent of choice in this purification process however recent push by environmental groups and agencies as well as tightening regulations have driven a desire to find a more benign alternative to benzene for this process. A review of the research and literature on potential alternative solvents for caprolactam purification is summarized with positives and drawbacks for each possible alternative.

O presente estudo avaliou a relação dos parâmetros do eixo II dos Critérios de Diagnóstico de Pesquisa das Disfunções Temporomandibulares (RDC/TMD) na resposta terapêutica de pacientes com DTM. Trinta e três pacientes (média de idade de 33,2 anos ± 13,4) com artralgia da articulação temporomandibular (ATM) foram submetidos a três terapêuticas: laser de baixa potência (LBP) + piroxicam (LPi), LBP + placebo de piroxicam (L) e piroxicam + placebo de LBP (Pi). Os pacientes receberam a terapêutica por 10 dias. As avaliações foram feitas na 1a e 4a sessões de tratamento. A presença e intensidade de dor espontânea, dor à palpação e máxima abertura bucal foram mensuradas. A evolução destas foi comparada à classificação dos pacientes de acordo com os parâmetros do eixo II: grau de dor crônica (GDC), depressão e sintomas físicos não específicos (SFNE). Os dados foram analisados usando os testes de Fisher, Wilcoxon, t de Student, Kruskal-Wallis, U de Mann-Whitney e análise de variâncias, adotando-se p<0,05 como nível de significância. Foi possível observar melhora significativa (p<0,05) dos pacientes estudados quanto ao tempo em relação à EVA e dor à palpação tanto muscular quanto articular. Notou-se diferença estatística significante (p<0,05) entre os grupos de GDC e abertura bucal 4ª sessão e dor articular; entre os grupos de SFNE (incluindo e excluindo itens de dor) e palpação muscular 1ª sessão. Entre os grupos de GDC e as variáveis de EVA e palpação muscular foi encontrada diferença marginalmente significativa, apresentando p-valores próximos a 0,05 (p<0,1). Não foi encontrada diferença estatística significante entre os grupos de depressão e as variáveis consideradas. Portanto, foi observada relação entre alta incapacidade e maiores médias dor articular, grau de SFNE incluindo e excluindo itens de dor classificados como severos e palpação muscular inicial. A depressão não apresentou relação com as variáveis estudadas.<br>The aim of this study was assess the influence of Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) Axis II parameters on treatment outcome of low-level laser therapy (LLLT) associated with piroxicam in patients with TMD. Thirty-two patients (mean age 33.2 years old ± 13.4) with temporomandibular joint (TMJ) arthralgia were enrolled in the study and received three kinds of treatment: LLLT + piroxicam (LPi), LLLT + placebo piroxicam (L) e piroxicam + placebo LLLT (Pi). Patients were managed for ten days. Follow-up evaluations were done at the 1st and 4th consults. The presence and intensity of spontaneous pain through the visual analogue scale (VAS), painful palpation and mandibular maximum vertical opening were measured. The therapeutic outcomes of this population were compared between the classifications of axis II scores: graded chronic pain (GCP), depression and non-specific physical symptoms (NEPS). The data was analyzed using the following statistic models: Fisher\'s test, Student t test, Wilcoxon, Mann-Whitney U test, Kruskal-Wallis test and Analysis of Variance. The statistical significance level set was p<0.05. The variables VAS, painful joint and muscle palpation showed improvement over time. Significant difference was found between GCP groups and maximum mouth opening on the 4th session and painful TMJ palpation; between NEFS (including and excluding pain items) and painful muscle palpation on the 1st consult. Between groups of GCP and VAS\'s variables it was found a marginally significant relation, showing p-values near 0.05 (p<0.1). No statistical difference was found on the comparison between depression and the physical variables considered. Thus, it is possible to conclude that there is an association between high incapacity and higher mean values to painful joint palpation, severe NEPS including and excluding pain items and baseline painful muscle palpation. No relation between depression and the studied variables was observed.

Deuxième pays le plus endémique pour le paludisme au monde, la république démocratique du Congo (RDC) a adopté officiellement l’initiative Faire Reculer le Paludisme en 2001 et depuis, aligne sa politique de lutte contre le paludisme sur les directives de l’OMS dont les orientations les plus récentes consistent en 3 stratégies :[1] assurer aux malades un accès rapide à un traitement efficace et abordable, [2] assurer aux personnes exposées au risque, notamment les jeunes enfants et les femmes enceintes, l’association la plus adaptée de mesures de protection au niveau personnel et communautaire et [3] donner l’accès, aux femmes enceintes exposées au risque, à des traitements préventifs.<p>Afin de contribuer à l’amélioration de la lutte antipaludique en RDC, le travail a été réalisé en 3 parties :une portant sur la pertinence du traitement préventif intermittent à la Sulfadoxine-Pyriméthamine (TPI-SP) chez la femme enceinte en contexte d’augmentation de la résistance du parasite, une 2e sur les facteurs déterminants l’adhésion des prestataires de soins, des vendeurs des médicaments et des patients à association Artesunate-Amodiaquine (AS-AQ) et une 3e décrivant le paludisme sévère chez l’enfant.<p>La 1ère partie du travail portant sur le TPI-SP a été réalisée en 2 temps. La première approche a consisté en une analyse rétrospective des poids de naissance des nouveau-nés en fonction de la prise du TPI-SP par les mères dans 3 maternités en 2007 où les niveaux de résistance à la SP étaient différents. La deuxième approche, comparait l’effet du traitement préventif intermittent à la Sulfadoxine-Pyriméthamine en 1998/1999 et en 2007 à la prophylaxie à base de chloroquine en 1998/1999 à l’Est de la RDC dans un milieu où la résistance à la Sulfadoxine-Pyriméthamine avait accru considérablement.<p>Dans les régions où la résistance du parasite était de faible (Mikalayi: 1,6% d’échec thérapeutique chez l’enfant) à modéré (Kisangani: 21,7% d’échec thérapeutique chez l’enfant), le TPI-SP réduit le risque de faible poids à la naissance, à Kisangani (OR ajusté :0,15; IC95%, 0,05-0.46) et à Mikalayi (OR ajusté :0,12; IC95%, 0,01-0,89). Dans ces 2 sites, le poids de naissance moyen des Nouveau-nés était plus élevé pour les mères ayant reçu 2 doses par rapport à celui des Nouveau-nés des mères en ayant reçu une seule ou aucune (P<0.001). A Rutshuru où la résistance était élevée (60,6% d’échec thérapeutique chez l’enfant), l’effet du TPI-SP semble moindre: en 2007 - en comparaison dose-dépendante (2 doses Vs 0-1 dose) du poids à la naissance des nouveau-nés en 2007 pour les mères sous TPI-SP – on observait un effet bénéfique chez les primigestes et non chez les multigestes et une légère régression du gain pondéral [(53,9g ( P=0,027) pour les nouveau-nés des mères sous SP en 2007 Vs 70,2g (P=0,003) pour ceux des mères sous SP en 1998/1999 par rapport à ceux des mères sous chloroquine en 1998/1999. Néanmoins, le TPI-SP reste efficace en 2007 comme en 1998-1999 par rapport à la prophylaxie à base de chloroquine en 1998/1999 (poids moyen supérieur et réduction du risque de PPN pour les 2 groupes sous SP). <p>La 2e partie, traitait des déterminants de l’adhésion des prestataires et des patients au nouveau médicament recommandé par la politique nationale pour la prise en charge des cas de paludisme simple ( AS-AQ ) en 2 enquêtes transversales :une étude préliminaire qui a été réalisée dans les CS fonctionnels de Kisangani en avril 2008 et une étude étendue à 3 des 10 districts sanitaires de la province Orientale de mars à juin 2009. Ces 2 enquêtes ont ensuite servi à une analyse systémique des facteurs d’adhésion des prestataires de soins à l’AS-AQ basée sur le modèle de diagnostic de Green et Kreuter et les étapes de changement de comportement de PROCHASKA pour la planification des interventions de promotion.<p>Le recours à l’AS-AQ pour le traitement du paludisme simple progresse (41% et 69% des prescriptions dans les services sanitaires respectivement 3 et 4 ans après le changement de politique national de lutte antipaludique), mais reste inférieur à la cible d’au moins 80% visée par la politique nationale. Malgré la croyance en l’efficacité du nouveau traitement, son utilisation effective rencontre comme principaux obstacles, selon l’avis des prestataires de soins, des vendeurs de médicaments et des patients, sa faible disponibilité, son coût élevé, la présence sur le marché d’antipaludiques retirés du protocole national de traitement et de l’AS-AQ de mauvaise qualité à un coût moindre et la crainte des effets indésirables. Tandis que les facteurs incitatifs à son utilisation sont, l’efficacité thérapeutique perçue de l’AS-AQ, la présence du médicament dans les formations sanitaires, la recommandation de son utilisation par les directives du Ministère de la Santé (notamment sous forme de guides techniques), la formation et la supervision des prestataires, l’intention de prescrire l’AS-AQ aux patients ou d’en prendre soi-même, une plus longue durée de consultation, le fait de fournir des explications aux patients, de travailler dans le milieu rural.<p>La dernière partie du travail consistait en une étude prospective menée du 1er janvier 2010 au 28 février 2011 décrivant le diagnostic et la prise en charge du paludisme grave chez les enfants admis dans 2 HGR de Kisangani.<p>Le paludisme constitue un des principaux motifs d’hospitalisation des enfants en RDC (37,0% à Kisangani) dont l’évaluation est souvent incomplète (53,6% avec goutte épaisse négative ou sans, insuffisamment explorés et traités comme paludisme grave) et le traitement parfois inadéquat (outre les affections non palustres probables non traitées, il y avait notamment surutilisation des produits sanguins exposant les enfants aux risques infectieux transfusionnels). Ainsi, les limites du plateau technique des HGR et l’organisation du circuit des malades semblent entraîner une sous-estimation, entre autre, des complications métaboliques du paludisme grave et des autres infections graves du jeune enfant et par conséquent des écarts au protocole de prise en charge préjudiciables aux patients.<p>Ces résultats mettent en lumière la nécessité :<p>•d’inscrire parmi les priorités du Programme National de Lutte contre le Paludisme, des recherches pour évaluer une option alternative au traitement préventif intermittent avec 2 doses de SP (traitement préventif intermittent avec d’autres antipaludiques) et à l’est du pays le recours préférentiel à la moustiquaire imprégnée à longue durée, en particulier chez la multigeste. <p>•de retenir, pour la promotion de l’utilisation de l’AS-AQ pour le traitement du paludisme simple, comme priorités :<p> o mettre à profit les opportunités actuelles de financement dans le domaine de la lutte antipaludique pour améliorer la disponibilité de l’AS-AQ à un coût accessible et à améliorer l’approvisionnement aussi bien des formations sanitaires publiques et privées que des officines pharmaceutiques ;<p> o assainir le secteur pharmaceutique de manière à endiguer la circulation d’antipaludique de mauvaise qualité à bas prix qui alimente les habitudes d’automédication courante dans les ménages ;<p> o élaborer des programmes de promotion de l’utilisation de l’AS-AQ, en élargissant la cible des interventions autant aux prestataires de soins du secteur privé qu’aux vendeurs de médicaments ;<p> o Adapter les programmes de promotion de l’AS-AQ au stade de changement de comportement auquel se trouve les acteurs après analyse des déterminants de leurs comportements notamment, les facteurs prédisposant (aussi bien les connaissances que les croyances et les intentions des prescripteurs), les facteurs potentialisant (notamment la disponibilité de l’AS-AQ de bonne qualité, son accessibilité financière aux patients) et les facteurs renforçant (supervision, contrats de performance).<p>•de renforcer le plateau technique des HGR et y améliorer le circuit des patients pour leur permettre de jouer pleinement leur rôle dans la prise en charge des formes graves du paludisme. /<p><p>Second most endemic country for malaria in the world, the Democratic Republic of Congo (DRC) has officially adopted the Roll Back Malaria (RBM) in 2001, since then aligns its malaria control policy on WHO guidelines which last orientations are based on three major strategies [1] prompt access to effective treatment and affordable for the patients [2] association of the most appropriate measures to protect the persons at risk both at individual and community level, including young children and pregnant women, [3] and access to preventive treatments to pregnant women at risk.<p>In order to contribute in improving malaria control in DRC, the study was carried out in three parts: the first one on the relevance of IPT with SP in pregnant women in the context of increased parasite resistance, the second one on the determinants of adherence of healthcare providers, drugs sellers and patients to AS-AQ, the last one describing severe malaria in children.<p>The first part of the study on IPTp-SP was performed in 2 stages. We had firstly carried out a retrospective analysis of birth weight comparing newborns whom mothers had received 2 SP doses to those whom mothers had received one or none, in three maternity hospitals in 2007 where levels of SP resistance were different. Then we evaluated the effect of IPTp-SP in 1998/1999 and 2007 compared to prophylaxis with chloroquine in 1998/1999 in eastern DRC in a region where resistance to SP was significantly increased. <p>In areas where parasite resistance was low (Mikalayi: 1.6% of therapeutic failure in children) our moderate (Kisangani: 21.7% of therapeutic failure in children), the IPTp-SP reduced the risk of LBW in Kisangani (OR adjusted 0.15, 95% CI, 0.04-0.58) and Mikalayi (adjusted OR, 0.12, 95% CI, 0.01-0.89). In both sites, the average birth weight was higher for mothers having received two rather than one or no SP doses (P<0.001). While in Rutshuru, where resistance was high (60.6% treatment failure), the effect of IPT-SP seems lower. In 2007, IPTp-SP had an effect only in primigravidae (dose-response comparison: 2 doses vs. 0-1dose). It was also observed in a slight decrease in body weight gain [(53.9 g (P = 0.027) for mothers having received SP in 2007 vs. 70.2 g (P = 0.003) for those mothers who had received SP in 1998/1999 compared to mothers who had received chloroquine in 1998/1999.<p>In the second part of the thesis, two cross-sectional surveys were carried out to identify determinants of the adherence of healthcare providers, drugs sellers and patients to the new drug recommended by the national policy for the treatment of uncomplicated malaria (AS-AQ). A preliminary survey was conducted in functional health centre in Kisangani in April 2008 and a second survey extended to three out of 10 health districts in the Eastern Province from March to June 2009. <p>The use of AS-AQ for the treatment of uncomplicated malaria progresses (from 41% to 69% prescriptions in health services between 2008 and 2009, 3 and 4 years respectively after the malaria control policy change), but still below the target of at least 80% pursued by national policy. Despite the perceived efficacy of AS-AQ by both healthcare providers and drugs vendors, its use was limited due to its low availability, high cost, mistrust on the quality of the available product, availability of inexpensive antimalarial drugs withdrew from national politicy and the fear for adverse effects. While the incentives for its use were, the therapeutic efficacy, availability, directives of the ministries of health (technical guidelines), training and supervision of healthcare providers, the intention to prescribe AS-AQ to patients or to use oneself, lengthy consultations, providing explanations to patients, working in rural areas.<p>The last part of the thesis was a prospective study conducted from January 2010 to February 2011 that included all children admitted for severe malaria with at least one of the criteria for severe malaria according to WHO.<p>Malaria is one of the main reasons for hospitalization of children in the DRC (37.0% in Kisangani) whose evaluation is often uncompleted (53.6% no or negative blood smear that are insufficiently explored and treated as severe malaria) and sometimes inadequately treated (in addition to non-malarial severe diseases treated as severe malaria, there was overuse of blood products conducting probably to exposition of children to risks of infection through transfusion). Thus, poor technical support and inadequate organization of the patient circuit seem to lead to underestimation, among others, of metabolic complications of severe malaria and in the non-recognition of other serious infections early childhood, problems that are detrimental to the patients, even when effective drugs are available.<p>These results highlight the need: <p>•to include among the priorities of the National Malaria Control Program, research to evaluate an alternative option to 2 doses IPTp-SP (IPT using other antimalarial drugs) and in the east of the country preferential use of MILD, especially in multigravidae. <p>•for the use of AS-AQ for the treatment of uncomplicated malaria primarily promote:<p> o the use of current funding opportunities in the field of malaria control to improve the availability of the AS-AQ at an affordable cost and to improve the supply of both public and private health facilities as well as pharmacies;<p> o to clean up the pharmaceutical sector in order to stem the flow of poor quality cheapest antimalarial drugs that feeds the habits of self-medication common in households;<p> o to develop communication programs, training and supervision of healthcare providers to promote the use of AS-AQ, expanding the target of interventions to both healthcare providers in the private sector and drugs sellers;<p> o To adapt AS-AQ promoting programs to the stage of behavior change after analysis of determinants of actors behavior, in particular, the predisposing factors (knowledge as well as beliefs and intentions of the prescriber), the potentializing factors (including the availability of the good quality AS-AQ, affordability to patients) and reinforcing factors (supervision, performance contracts).<p>•to strengthen the technical support of general hospitals and to improve the organization of the patient circuit in order to enable them to play their full role in the management of severe malaria.<p><br>Doctorat en Sciences de la santé publique<br>info:eu-repo/semantics/nonPublished

Made available in DSpace on 2014-07-29T15:21:57Z (GMT). No. of bitstreams: 1 dissertacao luciana pimenta e silva machado.pdf: 1454474 bytes, checksum: 09a4d7c1496bba377b1749ce79194bbc (MD5) Previous issue date: 2011-02-28<br>The aim of this study was to investigate the opinion of specialists in radiology, from different parts of the world, regarding to the proposed criteria for image acquisition and interpretation by Computed Tomography (CT), Cone Beam Computed Tomography (CBCT) and Resonance imaging (MRI) in diagnosing temporomandibular joint disorders (DATM) as part of Diagnostic Criteria for Research of Temporomandibular Disorders (RDC/TMD). Radiology specialists were invited by email to participate as volunteers in the study from three different eligible populations: researchers with publication DATM indexed on PubMed, ORADLIST members and individual contact. The link to access the questionnaire was mailed to volunteers interested in participating who matched the inclusion criteria. The sample was composed of specialists in radiology with experience in the interpretation of sectional images (CT, CBCT and/or MRI) of the temporomandibular joint (TMJ) who answered a questionnaire in English, which was developed and maintained online (LimeSurvey 1.87+). In a three months period, two recalls were sent and a period of 40 days after the last notification was given for responses submission. The questionnaire was divided into three parts with closed and open questions. Part I was related to issues of participant identification (gender, age, country of activity, area of activity, time and experience as a radiologist in the interpretation of sectional images of the TMJ and monthly time dedicated to the activity of interpreting sectional images of ATM). Part II contained questions related to the adequacy of the proposed criteria for the interpretation of sectional images of the ATM as part of the RDC/TMD. The criteria were presented into two columns' tables and the participants were asked whether that set of criteria was considered adequate or not for assessement and diagnosis of TMJ osseous and non-osseous tissues according to each imaging modality. If the respondent not considered criteria appropriate, he/she should indicate what type of suggestion: if insertion of new items, the modification or deletion of existing items. Part III had questions related to the need to include a minimal technical protocol for TMJ CT, CBCT and MRI acquisition as part of the RDC/TMD. If deemed necessary, the respondent should indicate which would be his/her suggestion protocol for acquisition of each imaging technique (CT, CBCT and MRI). Fifty-seven radiologists from different countries completed the questionnaire. The results indicate that 87 to 98% of radiologists considered the criteria adequate and that 81.6% of respondents considered necessary to include a minimal technical protocol for CT, CBCT and MRI acquisition as part of the RDC/TMD. Two to thirteen percent of respondents suggested insertion, modification and deletion of items in the proposed criteria. Ninety percent of respondents considered necessary to include a minimal technical protocol for CT/CBCT and 81.7% for MRI. We conclude that, according to the opinion of the worldwide community of specialists in radiology, the need for adjustments in the criteria for assessment of sectional images of the ATM is minimal, however, the need for the inclusion of a protocol to acquire minimal technical parameters of those images as part of protocol standardization of studies using the RDC/TMD is clear.<br>O objetivo desse estudo foi investigar a opinião de especialistas em radiologia, de várias partes do mundo, quanto aos critérios propostos para aquisição e interpretação de imagens por Tomografia Computadorizada (TC), Tomografia Computadorizada por Feixe Cônico (TCFC) e Ressonância Magnética (RM) no diagnóstico das desordens da articulação temporomandibular (DATM) como parte dos Critérios de Diagnóstico para Pesquisa das Desordens emporomandibulares (RDC/TMD). Especialistas em radiologia foram convidados por meio de e-mail a participar como voluntários do estudo a partir de três diferentes populações elegíveis: pesquisadores com publicação indexada sobre DATM no PubMed, membros da ORADLIST e contato individual. O link de acesso ao questionário foi enviado por email aos voluntários interessados em participar os quais preencheram os critérios de inclusão. A amostra foi composta por especialistas em radiologia com experiência na interpretação de imagens seccionais (TC, TCFC e/ou RM) da articulação temporomandibular (ATM) que responderam um questionário na língua inglesa, desenvolvido e mantido online (LimeSurvey 1.87+). Num período de três meses, duas notificações foram enviadas e um prazo de 40 dias após a última notificação foi estabelecido para o envio das respostas. O questionário foi dividido em três partes com perguntas fechadas e abertas. A parte I relacionava-se às questões de identificação do participante (gênero, idade, país de atuação, área de atividade, tempo de experiência como radiologista e na interpretação de imagens seccionais da ATM e o tempo de dedicação mensal à atividade de interpretar imagens seccionais da ATM). A parte II continha questões relacionadas à adequação dos critérios propostos para interpretação das imagens seccionais da ATM como parte do RDC/TMD. Os critérios foram apresentados em tabelas de duas colunas e os participantes eram questionados se aquele conjunto de critérios era considerado adequado ou não para a interpretação e diagnóstico dos tecidos ósseos e não-ósseos da ATM de acordo com cada modalidade de imagem. Caso não os considerasse adequado, deveria indicar qual o tipo de sugestão: se inserção de novos items, a modificação ou eliminação de itens existentes. A parte III continha perguntas relacionadas à necessidade de se incluir um protocolo técnico mínimo para a aquisição de TC, TCFC e RM como parte do RDC/TMD. Caso considerasse necessário, deveria indicar qual seria sua sugestão de protocolo para aquisição de cada uma das técnicas de imagem (TC, TCFC e RM). Cinqüenta e sete radiologistas de vários países responderam o questionário. Os resultados indicam que 87 a 98% dos radiologistas consideraram os critérios adequados e que 81,6% dos respondentes consideram necessária a inclusão de um protocolo técnico mínimo para aquisição das imagens por TC, TCFC e RM como parte do RDC/TMD. Dois a treze porcento dos respondentes sugeriram inserção, modificação e eliminação de items nos critérios propostos. Noventa porcento dos respondentes consideram necessária a inclusão de protocolo técnico mínimo para TC/TCFC e 81.7% para a RM. Conclui-se que, de acordo com a opinião da comunidade mundial de especialistas em radiologia, é mínima a necessidade de ajustes nos critérios para interpretação de imagens seccionais da ATM, entretanto, é clara a necessidade da inclusão de um protocolo técnico mínimo para a aquisição das referidas imagens como parte do protocolo de normatização das pesquisas que utilizam o RDC/TMD.

Le phénomène des Combattants dans la diaspora congolaise se révèle comme l’un des printemps chauds de l’histoire de la RDCONGO. Il traite de la réaction d’une diaspora devant l’absurdité de la guerre, de crises multiformes ainsi que de l’insécurité protéiforme dans une mère patrie taxée de scandale géologique à cause d’un sous-sol immensément riche, d’un écosystème diversifié et doté d’une exceptionnelle biodiversité, mais dont la population croupit dans l’indigence. Cette situation misérabiliste et paradoxale s’est traduite par une exaspération croissante qui a pris tout son sens dans la mobilisation des masses au sein de la diaspora qui intervient constamment, avec le fait des transferts d’argent. Depuis dix ans, la mobilisation des Combattants au sein de la communauté congolaise à l’étranger a marqué son empreinte dans les cinq continents. L’aspect visible de la mobilisation soudaine de cette communauté, internationale et originale par sa forme, n’a pas manqué de surprendre. Motivée par ce constat empirique, cette étude analyse ce phénomène inédit dans l’histoire de la République démocratique du Congo, dans la mesure où il met en jeu de nouvelles formes de mobilisations et de contestations qui, à notre avis, constituent une forme originale d’un mouvement contestataire à l’heure de la globalisation. L’étude analyse la mobilisation des Combattants par le prisme de la grille des nouveaux mouvements sociaux transnationaux ou des mouvements altermondialistes. De prime abord, elle propose ainsi un cadre de réflexion et développe une analyse rigoureuse du phénomène des Combattants : comprendre sa morphologie : sa structuration, son mode de fonctionnement, ses stratégies de militance, ses effets, ses causes et sa portée ; ensuite, elle rend compte du contenu de leur mobilisation dont quelques aspects touchent la question de l’humanité, de la dignité, de l’identité « Afropéenne » ou Afro-occidentale, de l’Ubuntu, des antagonismes, de la violence, de la dimension religieuse et de la responsabilité pour les générations futures. Elle saisit enfin à partir des perspectives élaborées par les membres de la diaspora africaine, comment les pratiques de la mobilisation transnationale participent concrètement à la construction du monde commun et dynamique autour des nouveaux acteurs dits « Afropéens » ou afro-occidentaux. Tout cela a permis, ensuite, à faire une lecture analytique de la mobilisation des Combattants à la lumière de théories et caractéristiques des NMST lorsque ces dernières se confrontent à la question des relations transnationales<br>The phenomenon of congolese combatants in the diaspora is proving to be one of the hot springs in the history of the DR CONGO. Il deals with the reaction of a diaspora faced with the absurdity of wars, multifaceted crises as well as protean insecurity in a country where geological scandals are common because of her rich natural ressources, her diverse ecosystem with an extraordinary biodiversity, but whose population languishes in abject poverty. This miserable and paradoxal situation has resulted in a growing exasperation that has taken on a sense of mobilizing of the masses within the diaspora constantly intervening, resulting in money transfers. Over the past ten years, the mobilization of these combatants within the Congolese community abroad has made its mark on all five continents. The visible aspect of the sudden mobilization of this community, international and original in its form, did not fail to surprise. Motivated by this empirical observation, this current study analyses this original phenomenon in the history of the Democratic Republic of Congo, inasmuch as it involves new forms of mobilization and protest which, in our opinion, constitute a form of an original protest movement in the age of globalization. This present study analyzes the mobilization of combatants through the prism of the grid of new socio-transnational movements or alter-globalization movements. In the first place, it thus proposes a framework for reflection and develops a rigorous analysis of the phenomenon of combatants : understanding its morphology : its structuring, its mode of operation, its strategies of militance, its effects, its causes and its scope; secondly, it takes into consideration the content of their mobilization, which affects some aspects of humanity, human dignity, "Afro-Western" (Afro-european) or Afro-Western identity, antagonisms, violence, religion and responsibility for future generations. Finally, from the perspectives elaborated by members of the African diaspora, it tackles how the practices of transnational mobilization are concretely involved in building the common and dynamic world around the new actors known as "Afropeans" or Afro-Westerns. All of this has allowed, then, to make an analytical reading of the combatants mobilization in the light of theories and NMST characteristics when they confront the issue of transnational relations

Disfunções Temporomandibulares e Dor Orofacial ou DTM, referem-se a um conjunto de alterações funcionais e/ou estruturais que se manifestam nas articulações temporomandibulares (ATMs), nos músculos da mastigação e nas estruturas associadas que compõem o aparelho mastigatório (Okeson, 2013). A DTM tem o potencial de não só interferir nas atividades funcionais do sistema estomatognático, mas também de afetar o comportamento social e psicológico do indivíduo. Este trabalho avaliou a amplitude dos movimentos mandibulares e a dor a palpação muscular no pré e pós-tratamento de participantes com DTM. Os participantes incluídos na pesquisa responderam ao Research Diagnostic for Temporomandibular Dysfunction (RDC/TMD) para viabilizar a formulação do diagnóstico de DTM e qualificar a dor a palpação dos músculos faciais, e submetidos à análise dos movimentos através de uma análise 3D, o JMA que avalia os movimentos mandibulares por vias ultrassônicas, no pré e póstratamento com placa estabilizadora por 30 e 60 dias. Os participantes foram reavaliados, com o objetivo de saber se haverá uma melhora na amplitude dos movimentos mandibulares pela abertura, lateralidades e protrusão e da movimentação condilar dentro da cavidade articular no plano sagital e frontal. Os resultados demonstraram não ter diferenças estatísticas na maior parte dos movimentos excursivos mandibulares (abertura, lateralidade e protrusão) avaliados tanto pelo sistema de ultrassom JMA quanto pelo exame do RDC/TMD. Na análise descritiva dos resultados obtidos através da palpação dos músculos na aplicação do RDC/TMD observamos uma grande melhora no quadro clinico de dor a palpação após 60 dias de uso da Placa Oclusal estabilizadora. Também não observamos diferenças estatisticamente significantes entre os dados coletados de amplitude dos movimentos pelo sistema informatizado JMA e pelo questionário RDC/TMD, ou seja, podemos afirmar que a avaliação pelo JMA é precisa e confiável.<br>Temporomandibular Disorders and Orofacial Pain or TMD, refer to a set of functional and / or structural changes that are manifested in the temporomandibular joints (TMJ) in the masticatory muscles and associated structures that make up the masticatory system (Okeson, 2013). The TMD has the potential to not only interfere with the functional activities of the stomatognathic system, but also affect the social and psychological behavior of the individual. This study evaluated the range of mandibular movements and muscle palpation pain in the pre and post-treatment of participants with TMD. Participants included in the study responded to the Research Diagnostic for Temporomandibular Dysfunction (RDC / TMD) to allow the formulation of a diagnosis of TMD and qualify pain palpation of the facial muscles, and subjected to analysis of movement through 3D JMA assessing movements mandibular by ultrasonic means, before and after treatment with stabilizing plate for 30 and 60 days. Participants were reassessed in order to know if there will be an improvement in the range of mandibular movements for opening, laterality and protrusion and condyle movement within the joint cavity in the sagittal and frontal plane. The results showed no statistical differences have in most excursive mandibular movements (opening, lateral and protrusive) assessed both by JMA ultrasound system as the examination of the RDC / TMD. In the descriptive analysis of the results obtained by palpation of the muscles in the application of the RDC / TMD noticed a great improvement in the clinical picture of pain palpation after 60 days of use board stabilizing occlusal. We did not observe statistically significant differences between the data collected from the range of motion by the computerized system JMA and the questionnaire RDC / TMD, other words, we can say that the evaluation by the JMA is accurate and reliable.

Cette thèse a pour but de comprendre et d’analyser les logiques d’émergence, les dynamiques de «fragmegration» ainsi que les mécanismes qui concourent à la perpétuation des mouvements politico-militaires au Congo-RDC. Dès le départ nous avons mis en exergue les trois tendances lourdes qui monopolisent le débat sur les rébellions en RDC. Ces trois tendances qui étaient fondamentalement des éléments accélérant ou amplificateurs, ont été à tort considérées comme les principaux éléments déclencheurs. Afin de lever la confusion conceptuelle entre ces deux principes, nous avons suggéré trois autres pistes de réflexion susceptible de mieux expliquer les phénomènes d’émergence, de fragmégration et de perpétuation. Ces pistes de réflexion sont les éléments déclencheurs majeurs autour desquels se structurent et s’articulent notre hypothèse. Dans cette thèse, nous soutenons l’argument selon lequel les phénomènes d’émergence, de fragmégration et de perpétuation sont une résultante de la militarisation des forces sociales congolaises, l’impossibilité du mouvement régional initié par le tandem rwando-ougandais à remporter une victoire clausewitzienne et l’institutionnalisation d’un partage de pouvoir complexe par la communauté internationale. Cette thèse est un appel au décloisonnement disciplinaire et à une multiplication des points d’entrée sur l’étude des groupes armés. D’où le recours à une approche (combinatoire) interdisciplinaire, mobilisant à la fois des courants critiques au sein des relations internationales (le constructivisme critique, la géopolitique) tout en alliant la sociologie des relations internationales plus particulièrement les acquis de la sociologie politique des mouvements sociaux. Notre approche interdisciplinaire qui est au centre de cette thèse peut aussi être d’une grande utilité dans le renforcement de l’approche polémologique fort utile pour saisir la gouvernance par les groupes politico-militaires.

Cette thèse porte sur l'implantation missionnaire en République démocratique du Congo sous l'administration coloniale belge vers la fin du XIXe siècle. Nous voulons comprendre le phénomène observé de la dépendance financière de cette Église, en situant ses différentes causes ou facteurs exogènes et endogènes notamment son ancrage dans la politique coloniale. Dès le début, elle a bénéficié des subventions de l’État et d'autres avantages importants, dont de vastes étendues de terres. Depuis sa prise en main par la hiérarchie autochtone, période correspondant à la décolonisation, cette Église n'arrive pas à se prendre en charge, obligée de se tourner constamment vers l'extérieur (tes organismes occidentaux de financement) pour assurer ses différents besoins. Or cette politique d'extraversion financière ne rassure plus, vu le contexte socioculturel occidental actuel (diminution des pratiques religieuses, crises financières mondiales, ...). En définitive, il faut à cette Église congolaise longtemps habituée à l'assistance de repenser une nouvelle logique d'action lui permettant de trouver d'autres possibilités pour assurer son autofinancement en vue de sa survie. L'objectif de ce travail est de montrer que des potentialités existent qu'elle peut exploiter: la mobilisation et la gestion rationnelle des ressources humaines et économiques disponibles, la rentabilisation des structures de productions héritées des missionnaires, mais en comptant sur un environnement sociopolitique et économique national favorable et un changement des mentalités des acteurs en présence<br>This thesis focuses the missionary presence in the Democratic Republic of Congo under the Belgian rule towards the end of the Sixth Century. We seek to understand bow this Church came to be financially dependent by looking at the different causes or exogenous and endogenous as well as the roots of this phenomenon within the context of the colonial policy. From the beginning, it has received State subsidies and enjoyed other significant advantages including large tracts of land. Ever since the native hierarchy has taken over, i.e. as from the decolonization, this Church has been unable to support itself and has been obliged constantly seek external aid from western financial bodies in order to meet its needs. But in the light of the current western sociocultural context (decline of religious practices, financial crises worldwide ... ) such a financial extraversion is no longer comforting. Ali things considered, long accustomed as it was to be assisted, this Congolese Church now needs to develop a new course of action through which it will be able to find other means of self-support for its survival. The objective of this work is to show that there is potential at band, namely the mobilization and the rational management of the human and economic resources available, the cost-effectiveness of the production facilities inherited from the missionaries, but resting on a favourable national sociopolitical and economic environment and a change in the attitude of the parties involved

Face aux préjudices irréparables engendrés par les crimes internationaux, le droit international, hormis les cas de poursuites devant la CPI et la pratique des commissions et fonds d'indemnisation des N.U, fait ponce-Pilate au droit interne pour la mise en oeuvre du droit à réparation des victimes de ces crimes. Une hypocrisie qui s'affirme notamment à travers des pratiques d'assistance humanitaire. Le droit interne des Etats quant à lui, fait un recours systématique à son système classique pour la mise en oeuvre de ce droit. Cet attrait pour le système classique tranche pourtant avec les facteurs matériels du droit en cette matière où le contexte des crimes, l'ampleur des préjudices, la vastitude des victimes et les fluctuations de la qualité des auteurs l'ont presque plongé dans la désuétude. C'est ce qui a fait émerger la quête d'un paradigme d'efficacité dont l'expérience de la justice transitionnelle et de la justice réparatrice constituent « l'essai ». La discussion sur l'efficacité des résultats de cet essai conduit l'observateur averti à la conclusion qu'il y a encore du chemin. Pour la RDC, contre l'aporie du droit classique face aux souffrances des victimes des crimes internationaux, cette étude propose la construction d'une politique criminelle basée sur une approche holistique de la réparation. L'approche holistique impliquant, ici, une réaction globaliste face aux préjudices subis par les victimes des crimes internationaux. Préjudices multiformes pour lesquels les réponses en termes de réparation doivent relever d'une appréhension globale du droit, reposant sur l'interdisciplinarité et l'ouverture à la « technologie sociale »<br>Faced with the irreparable prejudices arising from international crimes, except for the cases being prosecuted at the ICC and the processes of various Commissions and reparations funds of the UN, international law has been pontius-pilating when it comes implementing under domestic laws the rights of victims to reparations. This hypocrisy is particularly highlighted by the use of humanitarian aid. Domestic laws have systematically resorted to traditional practices to implement this right. This inclination towards traditional approaches is indeed at variance with the material elements of the law on reparations in as much as the context of the crimes, the scope of the damage, the vast number of victims and fluctuations in the types of perpetrators have simply made the traditional systems obsolete. Whence the quest for an efficiency paradigm hinged on «attempts» within transitional justice and reparations justice. Analyses of these attempts by experts reveal that a lot still has to be done. In the case of the DRC, and mindful of the shortcomings of the traditional legal system in mitigating the suffering of victims of international crimes, this study proposes a holistic approach to the development of a criminal reparations policy. This holistic approach requires a global response to the damage suffered by victims of international crimes. The reparations response to these multidimensional prejudices must reflect a global understanding of the law based on interdisciplinary and «social technology» considerations

RésuméContexte :Les avortements provoqués sont un problème de santé publique, et cela de par leur fréquence, la survenue de complication, et la mortalité et morbidité qui en découlent. Les décès peuvent ainsi représenter jusqu’à 18% de décès maternels. Très peu des données y relatives sont disponibles pour la RDC, alors que ce pays montre une mortalité maternelle très élevée avec un ratio qui est passé de 546 à 1188 décès maternels pour 100.000 naissances vivantes de 2007 à 2016 malgré l’amélioration de l’accessibilité et de l’utilisation des services de santé maternelle de 2001 à 2014. Objectif :Analyser les complications des avortements provoqués et les effets de l’intégration de la stratégie standard des soins après avortement dans les structures sanitaires de référence de la ville de Kinshasa, capitale de la RDC.Méthodes :L'analyse des complications des avortements provoqués incluait trois études transversales. La première étude a déterminé la prévalence des avortements provoqués et les complications y relatives. La deuxième et la troisième ont analysé les cas de complications des avortements provoqués admis dans les structures sanitaires de référence de Kinshasa du niveau secondaire et tertiaire successivement. Ensuite, l’analyse des effets de l’intégration de la stratégie standard des soins après avortement dans les structures sanitaires de référence de la ville de Kinshasa incluait une étude quasi expérimentale avec un design avant-après-comparatif. En outre, une étude qualitative avait été menée afin de contribuer à produire un modèle des soins après avortement adapté à la ville de Kinshasa.Résultats :Il ressort de nos études que le taux des avortements provoqués en 2015 était de 55 pour 1000 femmes en âge de procréer à Kinshasa, capitale de la RDC, et que la pratique de ces avortements était significativement plus souvent observée chez les femmes célibataires, séparées, ou divorcées, chez celles n’ayant pas étudié ou n’ayant fait que l’école primaire, et chez les consommatrices d'alcool, pour la plupart au moyen de doses élevées de médicaments administrées par les femmes elles-mêmes ou par des agents de santé. Un peu plus de la moitié de ces avortements avaient entraîné des complications, principalement hémorragiques, infectieuses, et traumatiques. Les patientes présentant ces complications représentaient entre 12,4 et 17,3% de l’ensemble des admissions dans les services de gynéco-obstétrique des structures sanitaires de référence du niveau secondaire, et environ 12,2% dans celle du niveau tertiaire. Dans ces structures, la durée médiane d'hospitalisation était de 9 à 10 jours, significativement plus longue pour des patientes ayant subi une intervention chirurgicale pour pelvipéritonite post perforation utérine que pour celles ayant subi une césarienne ou une hystérectomie. De plus, cette durée était significativement plus longue pour des patientes traitées pour d’autres types de complication post-abortive, que celles traitées pour un avortement spontané. Le taux de mortalité lié à ces complications était de 2,3 à 11,3% dans les structures du niveau secondaire, et de 37,8% dans celle du niveau tertiaire.La mise en place de la stratégie standard des soins après avortement dans les structures sanitaires de référence du niveau secondaire de la ville de Kinshasa a significativement amélioré la fréquence de la pratique de l’Aspiration Manuelle Intra-Utérine qui est passée de moins de 25% à 32−82% dans les structures expérimentales (p=0,025) au détriment de dilatation-curetage, ainsi que la durée d’hospitalisation des patientes admises pour une complication d’avortement provoqué (1 jour de moins dans les structures expérimentales, p=0,020). Par contre, elle n’a pas eu d’effets significatifs sur l’utilisation des services relatifs aux complications d’avortement provoqué, la létalité, et l’offre effective de la contraception moderne post avortement.Pour ce qui est des obstacles au succès des interventions qui visent l’amélioration de la prise en charge des complications des avortements provoqués dans les structures sanitaires de référence de la ville de Kinshasa, il y a notamment la culture, les normes sociales préétablies, la défaillance de l’éducation, le manque des moyens financiers, l’automédication, le manque d’un personnel formé, l’indiscrétion dans les structures sanitaires officielles, et les influences des pharmaciens/vendeurs des médicaments, des tradipraticiens, et des certains pasteurs.Conclusion :Les études présentées dans cette thèse ont montré que la pratique des avortements provoqués était fréquente à Kinshasa, capitale de la RDC, et que les complications survenaient dans plus de la moitié des cas, lesquelles complications n’étaient pas correctement prises en charge dans les structures sanitaires de référence et menaient à un décès dans plus de 5% de l’ensemble des cas. Ces études ont, en plus, permis de mettre en évidence une insuffisance des résultats de la stratégie standard des soins après avortement implémentée par le Ministère de la Santé Publique via le Programme National de Santé de la Reproduction, et de proposer une série d’actions de réajustementSummaryContext:Induced abortions are a public health problem because of their frequency, the occurrence of complications, and the resulting mortality and morbidity. Deaths can thus represent up to 18% of maternal deaths. Very little relative data is available for the DRC, although this country shows a very high maternal mortality with a ratio that went from 546 to 1188 maternal deaths per 100,000 live births from 2007 to 2016 despite the improvement in accessibility, and use of maternal health services from 2001 to 2014.Goal:Analyze the complications of induced abortions and the effects of integrating the standard postabortion care strategy into referral health structures in the city of Kinshasa, capital of the DRC.Methods:The analysis of complications from induced abortions included three cross-sectional studies. The first study determined the prevalence of induced abortions and related complications. The second and third analyzed the cases of complications from induced abortions admitted to the referral health structures in Kinshasa at the secondary and tertiary level. Then, the analysis of the effects of integrating the standard postabortion care strategy into referral health facilities in the city of Kinshasa included a quasi-experimental study with a before-after-comparative design. In addition, a qualitative study was carried out to help produce a postabortion care model adapted to the city of Kinshasa.Results:Our studies show that the rate of induced abortions in 2015 was 55 per 1000 women of childbearing age in Kinshasa, the capital of the DRC, and that the practice of these abortions was significantly more observed among single, separated or divorced women, those with no or only primary school education, and among female alcohol users, mostly with high doses of drugs administered by women themselves or by health workers. Just over half of these abortions resulted in complications, mainly hemorrhagic, infectious, and traumatic. Patients with these complications represented between 12.4 and 17.3% of all admissions to the gyneco-obstetrics departments of referral health facilities at the secondary level, and around 12.2% at tertiary level. In these facilities, the median duration of hospitalization was 9-10 days, and this period of time was significantly longer for the patients who underwent surgery for pelvic peritonitis due to uterine perforation compared with the patients who underwent Caesarean section/hysterectomy. Furthermore, it was significantly longer for the patients who were treated for other inducedabortion related complications compared with patients treated for spontaneous abortion. The mortality rate associated with these complications was 2.3-11.3% at secondary level facilities, and 37.8% at tertiary level facilities.The implementation of the standard postabortion care strategy in the referral health facilities at the secondary level of the city of Kinshasa has significantly improved the frequency of the practice of Manual Intrauterine Aspiration, which has gone from less than 25% at 32−82% in the experimental structures (p = 0.025) to the detriment of dilation-curettage, as well as the length of hospitalization of patients admitted for a complication of induced abortion (1 day less in the experimental structures, p = 0.020). However, it did not have a significant effect on the use of services related to induced abortion complications, the lethality, and the effective supply of modern postabortion contraception.Finally, with regard to the obstacles to the success of interventions aimed at improving the management of complications from induced abortions in referral health facilities in the city of Kinshasa, there is in particular the culture, the standards social pre-established, lack of education, lack of financial means, self-medication, lack of trained staff, indiscretion in official health structures, and the influences of pharmacists / drug sellers, traditional healers, and some pastors.Conclusion:The studies presented in this thesis showed that the practice of induced abortions was frequent in Kinshasa, the capital of the DRC, and that complications occurred in more than half of the cases, which complications were not well managed in the referral health facilities and led to death in more than 5% of cases. These studies have, in addition, made it possible to highlight an inadequacy of the results of the standard postabortion care strategy implemented by the Ministry of Public Health via the National Reproductive Health Program, and to propose a series of actions. readjustment<br>Doctorat en Sciences de la santé Publique<br>info:eu-repo/semantics/nonPublished

A falta de qualidade das obras públicas no Brasil povoa os noticiários diários. Os exemplos são abundantes, atribuídos a contratos mal elaborados, falhas graves nos projetos ou mesmo à ausência desses, licitações frustradas, obras interrompidas e superfaturadas, desvios de recursos e corrupção. Tentar compreender melhor essa situação é a motivação desta dissertação, que discorre sobre a contratação pública de projetos de edificações e, para isso, estuda o projeto e sua encomenda. A licitação é um procedimento obrigatório para a celebração de qualquer contrato público. Entre outros requisitos, a lei de licitações exige que a proposta seja a “mais vantajosa” para a administração, algo que tem levado à adoção indiscriminada do critério do “menor preço”, sendo incoerente com a doutrina jurídica e contrariando as pesquisas científicas, que consideram o projeto relevante para a qualidade final da obra. O problema de pesquisa questiona exatamente por que a Administração Pública tem contratado por menor preço um serviço que deveria ser contratado por critérios técnicos e de qualidade? O objetivo da dissertação é propor uma explicação para essa situação a partir de revisão bibliográfica, análise da legislação, realização de pesquisa documental com editais de licitação, aplicação de questionários de opinião com arquitetos e outros atores, além de entrevista direta com o autor da lei de licitações. Finalmente, o trabalho comprova a relevância do projeto, mas também desvenda sua irrelevância identificando que o menor preço não é o único problema e, mesmo que “todos” afirmem ser contra o menor preço, o povo segue pagando caro por projetos baratos.<br>The qualityless of public works in Brazil is currently in the daily news. Examples of it are plentiful, attributed to poorly drafted contracts, serious failures or even absence of projects, frustrated bids, discontinued and overpriced works, waste of resources and corruption. The motivation of this dissertation is trying to better understand this situation, which focuses on the public contracting of building projects and, for this, studies the project itself and its order. Bidding is a mandatory procedure for obtaining any public contract. Among other requirements, the bidding law requires that the proposal be the "most advantageous" for the administration, which ledded to the indiscriminate adoption of the "lowest price" criteria, incoerent with the juridical doctrine and opposite to scientific research, which consider the project relevant to the final quality of the building work. The research problem questions why the Public Administration has contracted for a lower price a service that should be contracted by technical and quality criteria? The objective of the dissertation is to propose an explanation for this situation from a bibliographical review, an analysis of the legislation, a documental research on bid’s documents, an opinion questionaries applying to architects and other actors, as well as direct interview with the author of the bidding law. Finally, the research proves the relevance of the project, but also reveals its irrelevance by identifying that the lowest price is not the only problem, and even if "everyone" claims to be against the lowest price, people continue to pay expensive for cheap projects.

The detonation-based engine has the key advantage of increased thermodynamic efficiency over the traditional constant pressure combustor. These detonation-based engines are also known as Pressure Gain Combustion systems (PGC) and Rotating Detonation Combustor (RDC) is a form of PGC, in which the detonation wave propagates azimuthally around an annular combustor. Prior researchers have performed a high fidelity 3-D numerical simulation of a rotating detonation combustor (RDC) to understand the flow physics such as detonation wave velocity, pressure profile, wave structure; however, performing these 3-D simulations is computationally expensive. 2-D simulations are a potential alternative to reduce computational cost. In most RDCs, fuel and oxidizer are injected discretely from separate plenums, and this discrete fuel/air injection results in inhomogeneous mixing within the domain. Due to the discrete fuel injection locations, fuel/oxidizer will stratify to form localized pockets of rich and lean mixtures. The motivation of the present study is to investigate the impact of unmixedness and stratification length scales on the performance of an RDC using a 2-D numerical approach. Unmixedness, which is defined as the standard deviation of equivalence ratio normalized by the mean global equivalence ratio, is a measure of the degree of fuel-oxidizer inhomogeneity. To model the effect of unmixedness in a 2-D domain, a lognormal distribution of the fuel mass fraction is generated with a mean equivalence ratio of 1 and varying standard deviations at the inlet boundary as a numerical source term. Moreover, to model the effects of stratification length scales, fuel mass fraction at the inlet boundary cells is bundled for a given length scale, and the mass fractions for these bundles are updated based on the lognormal distribution after every three-time steps. Using this methodology, 2-D numerical analyses are carried out to investigate the performance of an RDC for an H2-air mixture with varying unmixedness and stratification length scales. Results show that mean detonation velocity decreases and wave speed variation increases with an increase in unmixedness. However, with an increase in stratification length scale mean velocity remain relatively unchanged but variation in local velocity increases. The detonation wave front corrugation also increases with an increase in mixture inhomogeneity. The mean detonation cell size increases with an increase in unmixedness. The cell shape becomes more distorted and irregular with an increase in stratification length scale and unmixedness. The combined effect of unmixedness and stratification length scale leads to a decrease in pressure gain. Overall, this concept is able to elucidate the effects of varying unmixedness and stratification length scales on the performance of an RDC.<br>Master of Science<br>Pressure Gain Combustion (PGC) system has gained significant focus in recent years due to its increased thermodynamic efficiency over a constant pressure Brayton Cycle. Rotating Detonation Combustor (RDC) is a type of PGC system, which is thermodynamically more efficient than the conventional gas turbine combustor. One of the main aspects of the detonation process is the rapid burning of the fuel-oxidizer mixture, which occurs so fast that there is not enough time for pressure to equilibrate. Therefore, the process is thermodynamically closer to a constant volume process rather than a constant pressure process. A constant volume cycle is thermodynamically more efficient than a constant pressure Brayton cycle. In an RDC, a mixture of fuel and air is injected axially, and a detonation wave propagates continuously through the circumferential section. Numerical simulation of an RDC provides additional flexibility over experiments in understanding the flow physics, detonation wave structure, and analyzing the physical and chemical processes involved in the detonation cycle. Prior researchers have utilized a full-scale 3-D numerical simulation for understanding the performance of an RDC. However, the major challenge with 3-D analyses is the computational expense. Thus, to overcome this, an inexpensive 2-D simulation is used to model the flow physics of an RDC. In most RDCs, the fuel and oxidizer are injected discretely from separate plenums. Due to the discrete fuel injection, the fuel/air mixture is never perfectly premixed and results in a stratified flow field. The objective of the current work is to develop a novel approach to independently investigate the effects of varying unmixedness and stratification length scales on RDC performance using a 2-D simulation.

A partir de l'étude des interactions quotidiennes entre Katangais et Kasaïens, après les violences de masse perpétrées contre les Kasaïens « non originaires» au début des années 1990, la thèse montre que les Katangais et les Kasaïens mettent en œuvre, dans le cadre de leurs interactions en face-à-face (Goffman), des pratiques de coexistence fondées sur l'évitement, le silence et les non-dits. Le silence sur les violences passées et l'évitement des sujets politiques interprétables en fonction du conflit entre les deux communautés constituent en fait une norme interactionnelle de coexistence pacifique, à rebours de l'injonction au dialogue et à la compréhension mutuelle, qui est au cœur des pratiques des ONG de pacification « par le bas». La thèse montre également que dans certains contextes politiques ou socio-économiques macros constituant des situations de crise (Dobry ; Vidal), se produit un phénomène de polarisation des identités collectives : les Katangais et les Kasaïens ne sont alors plus perçus que par rapport à leur origine ethno-régionale. L'anticipation du déroulement des situations d'interaction devient plus difficile, du fait de I' « incertitude structurelle» qui caractérise ces situations de crise; et les pratiques routinisées de coexistence fondées sur l'autocensure et l'évitement tendent à diminuer. A partir de ces conclusions, la thèse interroge les injonctions morales à la réconciliation et au dialogue, qui sont à l'œuvre dans les théories et pratiques de pacification «par le bas», et la possibilité même d'une réconciliation «par le bas», diffusant de proche en proche une « culture de la paix » qui finirait par imprégner toute une société<br>Based on the study of daily interactions between Katangese and Kasaians, in the aftermath of the mass violence committed against the non-native Kasaians in the early 1990s, the dissertation shows that in their face-to-face interactions (Goffman), Katangese and Kasaians used practices of coexistence based on avoidance, silence, and self-censorship. Silence on the past violence and on political topics that can be interpreted with regard to the conflict between the two communities has indeed became an interactional norm of peaceful coexistence, unlike the injunction of NGOs specialized in the 'bottom-up' pacification to set up a dialogue that is deemed to foster a mutual understanding. The dissertation also shows that specific political or socio-economic contexts lead to 'crisis situations' (Dobry; Vidal). These crisis situations result in the polarization of collective identities: Katangese and Kasaians are viewed only by their ethno-regional origins. The expectations about interaction situations are made more difficult, because of the “structural uncertainty” that characterizes 'crisis situations'; and the routine practices of coexistence based on self-censorship and avoidance tend to disappear. From these findings, the dissertation questions the moral injunctions in favor of reconciliation and dialogue, which are at the heart of the theories and practices of 'bottom-up' pacification, and even the eventuality of a “bottom-up” reconciliation spreading step by step a 'culture of peace', which would eventually permeate society as a whole

ETIOLOGIE, CLASSIFICATION ET TRAITEMENT DES FISTULES TRAUMATIQUES GÉNITO-URINAIRES ET GÉNITO-DIGESTIVES BASSES (FTUG-DB) DANS L’EST DU CONGO. Objectif généralContribution à l’amélioration de la prise en charge de la FTUG-DB en RDC en :1) Clarifiant les étiologies des FTUG-DB en RDC.2) proposant une meilleure classification de la FTUG-DB afin de définir une stratégie opératoire adaptée.3) Évaluant les traitements de la FTUG-DB à l’hôpital Panzi.Objectifs spécifiques1. L’importance des fistules iatrogènes en RDC nous a amenés à étudier l’incidence et les caractéristiques des fistules d’origine iatrogènes (2 articles).- Cesarean delivery-related fistulae in the Democratic Republic of Congo. Onsrud M1, Sjøveian S, Mukwege D. International Journal of Gynecology and Obstetrics. 2011; 114(1):10-14- Complete destruction of urethra and bladder neck following symphysiotomy and results of attempted corrective surgery. Onsrud M1, Sjøveian S, Mukwege D. Acta Obstetricia et Gynecologica. 2008; 87(5):574-5762. Suite à la découverte de cette nouvelle étiologie qu’est la fistule traumatique due au viol avec extrême violence, nous avons voulu la définir, en comprendre les raisons afin de prévenir leur survenue et déterminer la morbidité résultante de la fistule traumatique après viol (4 articles).- Sexual violence-related fistulas in the Democratic Republic of Congo. Onsrud M1, Sjøveian S, Luhiriri R, Mukwege D. Int J Gynaecol Obstet. 2008 Dec; 103(3):265-9. - Rape as a strategy of war in the Democratic Republic of the Congo. Mukwege DM1, Mohamed-Ahmed O, Fitchett JR. Int Health. 2010 Sep; 2(3):163-4.- Rape with Extreme Violence: The New Pathology in South Kivu, Democratic Republic of Congo. Denis Mukengere Mukwege, Cathy Nangini. International Journal and Obstetrics 2009; 6(12)- No more! Organized rape in the Democratic Republic of the Congo must stop now. Mukwege D. International journal of gynecology and Obstetrics 2011; 114(1):1-33. Les classifications des fistules vésico-vaginales existantes nous semblaient incomplètes et peu prédictives des résultats opératoires. Nous avons proposé une classification des fistules uro-génitales sur la base de notre expérience, afin de déterminer une stratégie opératoire adaptée et de prédire les résultats du traitement (1 article).- Panzi Classification for Uro-Genital Fistula.Denis Mukwege, Lisa Peters, Christine Amisi, Janis M. Miller. (soumis au journal « The Lancet Global Health »)4. Face à l’augmentation inquiétante de viol d’enfants, nous avons développé une classification des fistules uro-génitales et digestives basses chez les enfants de moins de cinq ans et défini les attitudes thérapeutiques adaptées à cette classification (2 articles). - Classification of gender-based genitourinary and rectovaginal trauma in girls under 5 years of age. Mukwege D. International Journal of Gynecology and Obstetrics 2014; 124(2): 97-98- Treatment of rape-induced urogenital and low gastro-intestinal lesions in girls aged 5 and lessDenis Mukwege, Désiré Alumeti, Guy-Bernard Cadière, Jacques Himpens, (soumis au journal « International journal of gynecology and Obstetrics »)5. Les anciennes techniques chirurgicales par voie haute nous ont semblé très délabrantes. Nous avons proposé une nouvelle approche minimale invasive originale dans le traitement chirurgical des fistules traumatiques recto-vaginales hautes - Minimally invasive treatment of traumatic high rectovaginal fistulas. Mukwege D, Mukanire N, Himpens J, Cadière GB. Surg Endosc. 2015 (publication disponible online)6. Finalement, nous avons évalué les résultats du traitement chirurgical des FTUG-DB obstétricales à l’hôpital de Panzi (1 article).- Surgical outcome of obstetric fistula: a retrospective analysis of 595 patients. Sjøveian S, Vangen S, Mukwege D, Onsrud M. Acta Obstetrica et Gynecologica Scandinavica 2011; 90(7): 753-760CONCLUSIONLa FTUG-DB post-viol est rare en comparaison avec la FTUG-DB obstétricale mais cette étiologie nécessite une prévention et un traitement spécifique. Le viol est parfois réalisé avec une extrême violence et constitue une nouvelle pathologie à l’est de la RDC. Le VEV est utilisé comme stratégie de guerre.Un pourcentage important des FTUG-DB à l’Est de la RDC est d’origine iatrogène principalement par césarienne, mais aussi par hystérectomie et par symphysiotomie qui peut entraîner la destruction complète de l’urètre. La fistule due à une césarienne peut être considérée comme une entité clinique à part des FTUG-DB qui nécessite une stratégie opératoire spécifique. Ces résultats démontrent la nécessité de formation du personnel médical pour diminuer les FTUG-DB d’origine iatrogène. Les classifications des FTUG dans la littérature sont nombreuses, incomplètes, ambigües et peu prédictives .La classification de Panzi a été créée pour les FTUG. Elle est simple et hautement significative en terme de prédictivité du résultat chirurgical sur une série prospective de 728 patientes. La prise en charge des lésions génito-urinaires et digestives basses après viol chez les fillettes de 5 ans et moins selon la classification proposée dans la thèse, donne de bon résultat sur le plan fonctionnel et cosmétique.L’approche par laparoscopie et une stratégie opératoire selon une classification du délabrement du rectum, a permis de traiter les fistules recto-vaginal hautes, parfois larges et fibrosées, sans morbidité et avec succès dans 90% des cas.Les fistules post-obstétricale traitées à l’hôpital Panzi existaient à la fois chez les patientes primipares et multipares. Les fistules réparées pour la première fois, sans fibrose et avec une taille <2 cm, ont eu le meilleur résultat chirurgical. Ces résultats soulignent la nécessité d’être opéré d’emblée dans un hôpital de référence.Notre travail a confirmé que déterminer l’étiologie et la classification de ces fistules permet une meilleure stratégie opératoire et de transférer d’emblée les patientes sélectionnées vers un hôpital de référence.<br>Doctorat en Sciences médicales (Santé Publique)<br>info:eu-repo/semantics/nonPublished

Orientador: Ademir Petenate<br>Dissertação (mestrado profissional) - Universidade Estadual de Campinas, Faculdade de Engenharia Mecanica<br>Made available in DSpace on 2018-08-07T20:52:25Z (GMT). No. of bitstreams: 1 Rascop_SilvanaBorges_M.pdf: 3322702 bytes, checksum: e12f841b84d759a99603bf799e2fdf64 (MD5) Previous issue date: 2006<br>Resumo: O objetivo deste estudo foi aplicar a utilização o ¿Modelo de Melhoria¿, à gestão de controle em processo, visando a obtenção de qualidade no produto terminado e, posteriormente, implantá-lo em outras linhas de produção. O trabalho foi realizado no setor de revisão de produto final de uma indústria farmacêutica, na atividade de controle em processo. Utilizou-se o Modelo de Melhoria na determinação dos pontos críticos a serem trabalhados e as Normas de Amostragem por Atributos da ABNT para a determinação dos planos de amostragem. O estudo envolveu a avaliação de unidades do produto que já haviam passado pela revisão final e a determinação de itens com defeitos que não tinham sido separados pelo processo de revisão 100% caracterizando, assim, como falha de revisão. A reestruturação do Controle em Processo e o treinamento contínuo dos envolvidos propiciaram a diminuição do número de falhas ao longo do tempo, obtendo-se, com isto, melhoria de qualidade do produto terminado<br>Abstract: The objective of this study was to show that the use of the ¿Improvement Guide¿ methodology to obtain quality in products. The Improvement Guide Methodology was employed to determine the critical factors to be addressed and the ¿Sampling Rules¿ by attributes in acordance to ABNT (Brazilian Association of Technical Rules) was employed to determine the sampling plans. The study comprised the evaluation of samples that had already gone through the final revision process, thus bringing out defective items that had not been detected by the process, therefore being classified as 100% revision failure. By restructuring the process control and by creating an awareness of the employees envolved in the process, failures decreased through time and the problems were corrected, therefore leading toan improvement in the quality of the products<br>Mestrado<br>Gestão da Qualidade Total<br>Mestre Profissional em Engenharia Mecanica

A ingestão de ácidos graxos trans tem sido consistentemente mostrada ter efeitos adversos nos lipídeos sanguíneos, principalmente na razão LDL:HDL colesterol, que é um forte marcador de risco cardiovascular. De acordo com a Resolução RDC (Resolução da Diretoria Colegiada) de número 360 da ANVISA, de 23 de dezembro de 2003 da ANVISA, (Agência Nacional de Vigilância Sanitária), após 1 de agosto de 2006 as indústrias de alimentos devem declarar o conteúdo de ácidos graxos trans por porção do produto. O objetivo deste trabalho foi analisar a composição de ácidos graxos trans em margarinas e cremes vegetais após a nova legislação. As margarinas e cremes vegetais foram adquiridos na cidade de São Paulo, perfazendo um total de 40 amostras, 17 margarinas cremosas, 8 margarinas light, 1 margarina culinária cremosa, 2 margarinas culinária duras, 1 margarina culinária líquida, 2 alimentos a base de margarina, 8 cremes vegetais e 1 creme vegetal light foram analisados. Os lipídeos foram extraídos por hidrólise ácida, derivatizados com BF3 e em seguida analisados em cromatógrafo gasoso, equipado com coluna capilar SP- 2560 de 100 m a 180C. Os teores de trans totais das margarinas interesterificadas sofreram aumento significativo no período compreendido entre os anos 2000 a 2006, variando de 0 2,17% e 0,71 2,32% respectivamente. Nas margarinas hidrogenadas também foi observado aumento de 11,56 20,55% para 12,63 26,00% em 2006. As margarinas culinárias duras foram o tipo de margarina que apresentou concentrações elevadas de trans, variando de 19,38 a 30,35%. A margarina culinária cremosa e a margarina culinária líquida continham baixos teores de trans, 1,62 e 3,32% respectivamente. Os cremes vegetais interesterificados não sofreram mudança significativa, passando de 0 1,70% para 0 1,66%. No creme vegetal hidrogenado ocorreu redução acentuada dos teores médios de trans totais de 20,55 para 12,63%. A mudança na legislação não foi suficiente para reduzir totalmente os teores de ácidos graxos trans nas margarinas e cremes vegetais. Apesar disto, foi observado um aumento da disponibilidade de margarinas e cremes vegetais zero trans, que são aqueles que contém teores &#8804; 0,2 g/porção de 10 g.<br>Intake of trans fatty acids (TFA) has been consistently shown to have adverse effects on blood lipids, most notably on the LDL:HDL cholesterol ratio, which is a strong marker of cardiovascular risk. According to RDC (Resolução de Diretoria Colegiada) resolution number 360 of the ANVISA (Agência Nacional de Vigilância Sanitária National Agency for Sanitary Vigilance), after August 1, 2006, food industries must declare the trans fatty acid (TFA) content per product serving. The objective of this work was to analyzer the composition of trans fatty acid in margarines and fat spreads after the new legislation. The margarines and fat spread were obtained in the city of São Paulo, making a total of 40 samples, seventeen tub margarines, eight light tub margarines, one culinary tub margarine, two culinary hard margarines, one culinary liquid margarine, two margarine-based foods, eight fat spreads and one light fat spread were analyzed. The lipids were extracted by acid hydrolysis, derivatizados with BF3 and then analyzed by gas chromatograph, equipped with capillary column SP-2560 of 100 m a 180 C. The total TFA content in interesterified margarines significantly increased between 2000 and 2006, rising from 02.17% to 0.712.32%. For hydrogenated margarines, an increase was also observed, from 11.5620.55% to 12.6326.00% by 2006. The culinary hard margarines were the type of margarine that had high concentrations of trans, ranging from 19.38 to 30.35%. Culinary tub margarine and culinary liquid margarine contained low levels of trans, 1.62 and 3.32% respectively. Interesterified fat spreads did not significantly change, from 0 1.70% to 01.66%. In hydrogenated fat spreads, a sharp reduction was seen, with average levels of total trans fats falling from 20.55% to 12.63%. Changes in the legislative regulation were not sufficient to significantly reduce the levels of TFA in margarines and fat spreads. Nevertheless, an increased availability of zero trans fat margarines and fat spreads on the market was observed (levels &#8804; 0.2 g per 10 g serving).

nÃo hÃ<br>A deficiÃncia de ferro à o distÃrbio nutricional mais prevalente no mundo. No Brasil, a deficiÃncia de ferro tem sido reconhecida como importante causa de anemia hà mais de duas dÃcadas. A anemia ferropriva configura um problema epidemiolÃgico da maior relevÃncia influindo nos gastos pÃblicos de saÃde. Dentre os fatores que contribuem para essa causa està a baixa ingestÃo de ferro que à favorecida por condiÃÃes precÃrias de vida. A fortificaÃÃo com ferro nos alimentos amplamente consumidos pela populaÃÃo vem sendo utilizada como estratÃgia para melhorar a situaÃÃo nutricional nas populaÃÃes de diversos paÃses. O objetivo deste estudo foi avaliar os teores de ferro dos produtos obtidos com farinhas de trigo e milho comercializados no Estado do Cearà por meio do Programa de AvaliaÃÃo do Teor Nutricional do MinistÃrio da SaÃde (PATEN) em um estudo do tipo retrospectivo quantitativo de avaliaÃÃo dos teores de ferro em anÃlises realizadas no LaboratÃrio Central de SaÃde PÃblica do Estado do Cearà (LACEN). A partir de entÃo, buscou-se verificar o atendimento dos produtos comercializados no Estado do Cearà à ResoluÃÃo da Diretoria Colegiada n 344/2002/ANVISA, que torna obrigatÃria a fortificaÃÃo de farinhas de trigo e milho com ferro e Ãcido fÃlico, assim como, comparar dados relativos à prevalÃncia de anemia ferropriva das duas Ãltimas dÃcadas no Brasil. Concluiu-se que aproximadamente 58% das amostras analisadas, nos Ãltimos trÃs anos, foram consideradas insatisfatÃrias em relaÃÃo ao atendimento da RDC n 344/2002/ANVISA, ou seja, possuem teor de ferro menor que 4,2 mg por cada 100 g de farinha. Por sua vez, a prevalÃncia de anemia ferropriva no Brasil nÃo se alterou significativamente ao longo de duas dÃcadas, mesmo com a obrigatoriedade da fortificaÃÃo das farinhas com ferro.<br>Iron deficiency is the most prevalent nutritional disorder in the world. In Brazil, iron deficiency has been recognized as an important cause of anemia for more than two decades. Iron deficiency anemia sets up an epidemiological problem of great importance that has influenced the health public spending. Among the factors that contribute to this cause is the low intake of iron, influenced by poor living conditions. The iron has been used in foods widely consumed by the population as a strategy to improve the nutritional status of populations in several countries. This study was carried out to evaluate the iron content of wheat and corn flour products available in the State of Cearà through the Nutritional Content Assessment Program of Health Ministry (PATEN) in a quantitative and retrospective kind of study of iron content assessment through analysis realized by the Central Public Laboratory of Ceara State (LACEN). Thus, attempting to verify the compliance of the products sold in the state of Ceara to The Board Resolution Collegiate, RDC N 344/2002/ANVISA, which obligates the fortification of wheat and maize flour with iron and folic acid, as well as to compare the prevalence of iron deficiency anemia in the the last two decades in Brazil. It was concluded that approximately 58% of the samples analyzed in the last three years were considered unsatisfactory in relation to RDC No. 344/2002/ANVISA, ie having iron content of less than 4.2 mg per 100 g of flour. In turn, the prevalence of iron deficiency anemia in Brazil has not changed significantly over the last two decades, even with the mandatory fortification of flour with iron.

Made available in DSpace on 2011-12-27T14:14:41Z (GMT). No. of bitstreams: 2 000400560-0.pdf: 988153 bytes, checksum: 1225d66d41cddc3674b6f7591ab35e4f (MD5) license.txt: 581 bytes, checksum: 44ea52f0b7567232681c6e3d72285adc (MD5)<br>The primary objective of this study was to determine, in our cultural background, the validity of the RDC/TMD (Research Diagnostic Criteria for Temporomandibular Disorders) as a diagnostic tool for patients with temporomandibular disorders. Sixty nine patients with TMD and 70 subjects from the control group, all females, underwent the RDC/TMD and were compared in a case-control study. The second objective was to verify the prognostic validity of the RDC/TMD in a longitudinal treatment outcome study. Patients with TMD underwent conservative treatments (bite-splints and occlusal adjustment, etc. ) according to the treating clinician, who was blind to all RDC/TMD results. These patients were recalled after six months for a re-evaluation of orofacial pain intensity. The improvement criteria for patients to be included in the responding group (rTMD) was a 30% reduction in pain intensity at rest as compared to baseline using Visual Analogue Scales (VAS). The results were also compared to a patient’s self-assessment scale (better/same/worse) to determine the degree of reliability. Patients who improved were included in Group I (rTMD). Those who did not improve (nonresponding TMD) were part of Group II (nrTMD). Asymptomatic controls were included in Group III. The database and statistical analyses were made in the SPSS version 11. 5 for Windows. The variables were both categorical/recoded as well as continuous; therefore, both parametric (Student’s t test, two-sided test, ANOVA, P<0. 05) and non-parametric (Pearson’s Chi-Square, Fisher’s exact test, two-sided test, P<0. 05) tests were used. The results comparing TMD patients versus controls have shown that 57. 1 % of patients in the test group were diagnosed with miofascial pain.Disk intereference with reduction was observed in 24. 3 % of temporomandibular joints on the left side and in 18. 6 % of those on the right side. The diagnosis of arthralgia was identified in 61. 4% of joints on the left side as well as in 62,9 % of those on the right side. The Chronic Pain Grade was of mild intensity for 60. 9% of patients, and the Chronic Pain Intensity was 66. 9 on average for the test group and 0. 01 for controls. The Disability Points was moderate for 20% of the test group. The average depression score was 1. 02 in the test group and 0. 56 in the control one. Depression was moderate for 40% of patients as well as for 22. 9% in controls. Somatization with pain was 1. 25 on average for TMD patients and 0. 44 in controls. Moderate somatization with pain was found in 30% of TMD patients and 27. 5% in controls. Somatization without pain was 1. 12 on average for the test group and 0. 35 in the control group. Moderate somatization without pain was observed in 25. 7 % in patients and 24. 3 % in controls. The results have shown statistically significant difference between TMD patients and controls. However, when we compare responding versus non-responding TMD patients, no significant difference was observed for any of the items studied. Therefore, it is concluded that the diagnostic validity was positive, but not the prognostic one.<br>O primeiro objetivo deste estudo foi determinar, no nosso meio, a validade dos Critérios de Diagnóstico de Pesquisa das Desordens Temporomandibulares RDC/TMD como fator de diagnóstico em pacientes com desordens temporomandibulares. Sessenta e nove pacientes com DTM e 70 pessoas do grupo-controle, todas do gênero feminino, foram submetidas aos Critérios de Diagnóstico de Pesquisa das Desordens Temporomandibulares (RDC/TMD) e comparados em um estudo caso-controle. O segundo objetivo foi o de verificar a validade prognóstica do RDC/TMD através de um estudo longitudinal tipo resultado de tratamento. As pacientes com DTM foram submetidas a tratamento por meio de dispositivos - placas de mordida e/ou ajuste oclusal, etc. , da maneira que o clínico responsável julgou necessário, o qual foi “cego” a todos os resultados do RDC/TMD. Estas pacientes foram chamadas seis meses após o tratamento realizado para a reavaliação da intensidade de dor orofacial. O critério de melhora clínica para que as pacientes com DTM pudessem ser incluídas no grupo de respondentes ao tratamento (rDTM), foi uma redução de 30% na intensidade da dor sobre a avaliação de dor em repouso no início do tratamento, utilizando-se escalas visuais análogas (VAS). Os resultados foram comparados com a auto-avaliação da paciente (melhor/igual/pior) para determinar o grau de confiabilidade dos resultados. As pacientes que melhoraram foram incluídas no Grupo 1a (rDTM). Aquelas que não melhoraram fizeram parte do Grupo 1b (nrDTM) e os assintomáticos foram incluídos no Grupo 2. A base de dados e a análise estatística foram realizadas no programa SPSS versão 11. 5 para Windows®.As variáveis foram ambas categóricas/recodificadas e contínuas; portanto, tanto testes não-paramétricos (Pearson’s Chi-Square, Fisher’s exact test, two-sided test, P<0. 05) quanto paramétricos (Student’s t test, two-sided test, ANOVA, P<0. 05) foram empregados. Os resultados comparativos entre pacientes com DTM e controle mostraram que 57,1 % das pacientes do grupo-teste foram diagnosticadas com desordem miofascial. O deslocamento de disco com redução ocorreu em 24,3 % das articulações do lado esquerdo e em 18,6 % das articulações no lado direito. O diagnóstico de artralgia foi estabelecido em 61,4% nas articulações do lado esquerdo e em 62,9 % nas articulações do direito. O grau de dor crônica foi de média intensidade para 60,9 %, a incapacidade por dor crônica foi em média de 66,9 para o grupoteste e de 0,01 para o grupo-controle. A incapacidade foi moderada para 20 % do grupo-teste. A depressão média foi de 1,02 no grupo-teste e de 0,56 no grupo-controle. A depressão foi moderada para 40 % das pacientes do grupo-teste e para 22,9 % no grupo-controle. A somatização com dor foi em média de 1,25 no grupo-teste e de 0,44% no grupo-controle. Ela foi moderada para 30 % das pacientes do grupo-teste e 27,5 % no grupo-controle. A somatização sem dor foi em média de 1,12 no grupo-teste e de 0,35 no grupo-controle. A somatização moderada ocorreu em 25,7 % das pacientes do grupo-teste e em 24,3 % no grupo-controle. Os resultados apresentaram diferenças estatísticamente significativas entre os grupos teste e controle. Ao comparar as pacientes respondentes e não respondentes ao tratamento da DTM não foram evidenciadas diferenças estatísticamente significantes para qualquer um dos ítens estudados. Portanto, concluiu-se que a validade de diagnóstico foi positiva, mas a validade prognostica foi negativa.

Les forêts du Cameroun, du Congo, du Congo RCD et du Gabon regorgent d’énormes ressources. Plusieurs potentialités sont offertes à ces pays par la richesse et la diversité de la faune, la flore, l’exploitation des ressources du sous-sol, du bois et des produits forestiers non ligneux. L’exploitation forestière de ces ressources pourrait être un moyen efficace pour l’amélioration des conditions de vie des populations locales et autochtones qui dépendent de ces forêts. Toutefois, malgré les mécanismes juridiques, politiques et économiques mis en place par les différents gouvernements, la participation des populations à la gestion des forêts reste très relative. La promotion et la protection de leurs droits sociaux et économiques demeurent aussi problématiques<br>The forests of Cameroon, Congo, CongoRCD and Gabon are full of enormous resources. Several possibilities are available to these countries by the richness and diversity of fauna, flora, exploitation of resources underground resources, wood and non wood forest products. Logging of these resources could be an effective means of improving the living conditions of local and indigenous people who depend on these forests. However, despite the legal, political and economic setup by different governments, people's participation in forest management is very relative. The promotion and protection of their social and economic rights also remain problematic

MELO, Cintia de Brito. Fortificação de alimentos com ferro: verificação do atendimento à RDC nº 344/2002/ANVISA no Estado do Ceará. 2016. 49 f. Dissertação (mestrado em ciência e tecnologia de alimentos)- Universidade Federal do Ceará, Fortaleza-CE, 2016.<br>Submitted by Elineudson Ribeiro (elineudsonr@gmail.com) on 2016-03-22T18:41:11Z No. of bitstreams: 1 2016_dis_cbmelo.pdf: 1003999 bytes, checksum: db40a2cc654e8358a812b453ba454998 (MD5)<br>Approved for entry into archive by José Jairo Viana de Sousa (jairo@ufc.br) on 2016-05-18T18:38:11Z (GMT) No. of bitstreams: 1 2016_dis_cbmelo.pdf: 1003999 bytes, checksum: db40a2cc654e8358a812b453ba454998 (MD5)<br>Made available in DSpace on 2016-05-18T18:38:12Z (GMT). No. of bitstreams: 1 2016_dis_cbmelo.pdf: 1003999 bytes, checksum: db40a2cc654e8358a812b453ba454998 (MD5) Previous issue date: 2016<br>Iron deficiency is the most prevalent nutritional disorder in the world. In Brazil, iron deficiency has been recognized as an important cause of anemia for more than two decades. Iron deficiency anemia sets up an epidemiological problem of great importance that has influenced the health public spending. Among the factors that contribute to this cause is the low intake of iron, influenced by poor living conditions. The iron has been used in foods widely consumed by the population as a strategy to improve the nutritional status of populations in several countries. This study was carried out to evaluate the iron content of wheat and corn flour products available in the State of Ceará through the Nutritional Content Assessment Program of Health Ministry (PATEN) in a quantitative and retrospective kind of study of iron content assessment through analysis realized by the Central Public Laboratory of Ceara State (LACEN). Thus, attempting to verify the compliance of the products sold in the state of Ceara to The Board Resolution Collegiate, RDC Nº 344/2002/ANVISA, which obligates the fortification of wheat and maize flour with iron and folic acid, as well as to compare the prevalence of iron deficiency anemia in the the last two decades in Brazil. It was concluded that approximately 58% of the samples analyzed in the last three years were considered unsatisfactory in relation to RDC No. 344/2002/ANVISA, ie having iron content of less than 4.2 mg per 100 g of flour. In turn, the prevalence of iron deficiency anemia in Brazil has not changed significantly over the last two decades, even with the mandatory fortification of flour with iron.<br>A deficiência de ferro é o distúrbio nutricional mais prevalente no mundo. No Brasil, a deficiência de ferro tem sido reconhecida como importante causa de anemia há mais de duas décadas. A anemia ferropriva configura um problema epidemiológico da maior relevância influindo nos gastos públicos de saúde. Dentre os fatores que contribuem para essa causa está a baixa ingestão de ferro que é favorecida por condições precárias de vida. A fortificação com ferro nos alimentos amplamente consumidos pela população vem sendo utilizada como estratégia para melhorar a situação nutricional nas populações de diversos países. O objetivo deste estudo foi avaliar os teores de ferro dos produtos obtidos com farinhas de trigo e milho comercializados no Estado do Ceará por meio do Programa de Avaliação do Teor Nutricional do Ministério da Saúde (PATEN) em um estudo do tipo retrospectivo quantitativo de avaliação dos teores de ferro em análises realizadas no Laboratório Central de Saúde Pública do Estado do Ceará (LACEN). A partir de então, buscou-se verificar o atendimento dos produtos comercializados no Estado do Ceará à Resolução da Diretoria Colegiada nº 344/2002/ANVISA, que torna obrigatória a fortificação de farinhas de trigo e milho com ferro e ácido fólico, assim como, comparar dados relativos à prevalência de anemia ferropriva das duas últimas décadas no Brasil. Concluiu-se que aproximadamente 58% das amostras analisadas, nos últimos três anos, foram consideradas insatisfatórias em relação ao atendimento da RDC nº 344/2002/ANVISA, ou seja, possuem teor de ferro menor que 4,2 mg por cada 100 g de farinha. Por sua vez, a prevalência de anemia ferropriva no Brasil não se alterou significativamente ao longo de duas décadas, mesmo com a obrigatoriedade da fortificação das farinhas com ferro.

Submitted by Biblioteca da Faculdade de Farmácia (bff@ndc.uff.br) on 2017-03-24T18:08:18Z No. of bitstreams: 1 Silva, Juliana Fróes da Cruz [Dissertação, 2015].pdf: 1526465 bytes, checksum: 9188e606a15d2535c12652e29421199f (MD5)<br>Made available in DSpace on 2017-03-24T18:08:18Z (GMT). No. of bitstreams: 1 Silva, Juliana Fróes da Cruz [Dissertação, 2015].pdf: 1526465 bytes, checksum: 9188e606a15d2535c12652e29421199f (MD5)<br>A indústria farmacêutica é uma das mais estáveis e rentáveis do mundo. A propaganda de medicamentos é uma forma de investimento através da divulgação, com ênfase na marca, visando promover a aquisição de seus produtos. O objetivo deste trabalho é analisar as irregularidades de propagandas de Medicamentos Isentos de Prescrição, destinadas ao público leigo, veiculadas em mídia televisiva no município do Rio de Janeiro e Região Metropolitana. Duas das emissoras de maior audiência da televisão aberta do Rio de Janeiro foram monitoradas durante dezembro/2013 a junho/2014. As peças coletadas foram analisadas frente à Resolução da Diretoria Colegiada 96/08, e posteriormente transcritas. Foram encontradas 90 inserções publicitárias no período, sendo consideradas 33 peças únicas. Todas elas apresentavam alguma infração. A média foi de 3,6 infrações por peça. É notável a presença dos grupos terapêuticos dos analgésicos, anti-inflamatórios, antigripais e antiácidos. Este estudo concluiu que as infrações à normatização continuam preocupantemente altas, evidenciando a fragilidade da regulamentação e fiscalização da propaganda de medicamentos no Brasil e a necessidade de mudanças, priorizando a promoção do uso racional de medicamentos<br>The pharmaceutical industry is one of the most stable and profitable in the world. The drug advertising is a form of investment through the dissemination, with emphasis on brand, to promote the purchase of their products. The objective of this study is to analyze the irregularities of Over-the-counter drugs advertisements to the lay public, broadcast in television media in the city of Rio de Janeiro and the metropolitan area. Two of the highestrated open television stations in Rio de Janeiro were monitored during December/2013 to June/2014. The collected pieces were analyzed against the ANVISA Board Resolution 96/08, and later transcribed. 90 advertising inserts were found in the period, considering 33 unique pieces. They all had some infraction. The average was 3.6 violations per piece. It is noteworthy the presence of the therapeutic groups of analgesics, anti-inflammatory, antacids and flu medicine. This study concluded that violations of the norms still worryingly high, demonstrating the fragility of the regulation and supervision of drug advertising in Brazil and the need for change, giving priority to promoting the rational use of medicines

Submitted by isabela.moljf@hotmail.com (isabela.moljf@hotmail.com) on 2017-05-17T12:11:32Z No. of bitstreams: 1 glauciaarleudasilva.pdf: 3423860 bytes, checksum: 769aaed9184977e90b0c5f5446d55722 (MD5)<br>Approved for entry into archive by Adriana Oliveira (adriana.oliveira@ufjf.edu.br) on 2017-05-17T16:16:18Z (GMT) No. of bitstreams: 1 glauciaarleudasilva.pdf: 3423860 bytes, checksum: 769aaed9184977e90b0c5f5446d55722 (MD5)<br>Made available in DSpace on 2017-05-17T16:16:18Z (GMT). No. of bitstreams: 1 glauciaarleudasilva.pdf: 3423860 bytes, checksum: 769aaed9184977e90b0c5f5446d55722 (MD5) Previous issue date: 2010-07-30<br>O objetivo deste trabalho foi avaliar a acurácia dos Critérios de Diagnóstico para Pesquisa das Desordens Temporomandibulares (RDC/DTM), a partir da comparação com o exame de imagem por ressonância magnética (IRM) no diagnóstico dos deslocamentos de disco da articulação temporomandibular em pacientes que buscaram tratamento para desordem temporomandibular. Vinte pacientes foram avaliados, totalizando 40 articulações examinadas. Para detectar anormalidades na posição do disco clinicamente foi empregado o uso do RDC/DTM, por um único examinador calibrado, “cego” para os exames de IRM. O diagnóstico das IRM obtidas dos pacientes foi realizadas por dois especialistas em radiologia odontológica, “cegos” para o exame clínico. Com base na estatística Kappa, foram observados níveis aceitáveis de confiabilidade intra-examinador na aplicação do RDC/DTM, e intra e interexaminador na avaliação das IRM. Os valores de kappa para a concordância entre o RDC/DTM e IMR foram melhores nos diagnósticos de deslocamento de disco do lado direito (k=0,913). Neste estudo, o RDC/DTM mostrou-se válido para diagnosticar deslocamentos de disco articular da ATM, com acurácia de 95% para a avaliação das ATM do lado direito e 75% do lado esquerdo, evidenciando a necessidade de um exame padronizado realizado por investigadores treinados na avaliação de pacientes com DTM.<br>The aim of this study was to evaluate the accuracy of the Research Diagnostic Criteria to Temporomandibular Disorders (RDC/TMD), from the comparison with magnetic resonance imaging (MRI) findings in the diagnosis of disc displacements of the temporomandibular joint in patients seeking treatment for temporomandibular disorders. Twenty patients were evaluated in a total of 40 joints examined. To detect abnormalities in disc position was employed clinically using the RDC/TMD, by a single calibrated examiner, “blinded” to the MRI scans. The diagnosis of MRI was obtained from patients performed by two specialists in oral radiology, “blinded” to the clinical examination. Based on the Kappa value, were found acceptable levels of reliability intra examiner in the application of RDC/TM, and intra e inter examiner in the evaluation of MRI. Kappa values for agreement between RDC/TMD and MRI were better in the diagnosis of disc displacement on the right side (k = 0.913). In this study, the RDC/TMD was valid for diagnosing disc displacement of the TMJ, with 95% accuracy for the evaluation of ATM on the right side and 75% of the left side, suggesting the need for a standardized examination conducted by trained investigators in the evaluation of patients with TMD.

Em novembro de 2005, com o guia de Gestão de Riscos à Qualidade (Q9) - a Conferência Internacional de Harmonização (ICH), em conjunto com as agências regulatórias dos Estados Unidos, Japão e Europa, passaram a recomendar que seja aplicado o gerenciamento de riscos para regulação da indústria farmacêutica. Em concordância, a Agência Nacional de Vigilância Sanitária (ANVISA) publicou a Resolução de Diretoria Colegiada - RDC 17/2010 que dispõe sobre as Boas Práticas de Fabricação de Medicamentos que possibilita a comercialização de produtos farmacêuticos. Esta resolução preconiza que a validação de um processo produtivo seja efetuada com base em uma análise de risco. Seguindo as orientações da RDC este trabalho se propôs a aplicar a ferramenta de análise de risco de Estudos de Perigos e Operabilidade HAZOP num sistema de biorreação bacteriana para produção de proteínas recombinantes instalado no Instituto de Tecnologia em Imunobiológicos Bio-Manguinhos/Fiocruz. Este sistema é formado por fermentadores de 100 (FE01) e 600 (FE02) litros, um tanque de colheita de 600 litros (HT01) e um tanque de preparo de meios de cultura de 600 litros (MT01). Através da aplicação desta ferramenta de análise de riscos foi possível classificar os riscos dos sistemas identificando os nós, palavras-guia primárias (parâmetros) e secundárias (desvios), assim como a severidade e frequência dos eventos. Foram identificados 82 riscos associados aos fermentadores FE01 e FE02, sendo 8,5% riscos insignificantes, 65,9% riscos aceitáveis e 25,6% riscos não desejáveis. No tanque de colheita HT01 foram identificados 55 riscos, dos quais 14,5% são insignificantes, 67,3% são aceitáveis e 18,2% não desejáveis. Para o tanque de preparo de meios MT01 foram identificados 66 riscos que estão divididos em 9% de riscos insignificantes, 69,7% de riscos aceitáveis e 21,3% de riscos não desejáveis. Foi percebido que não houve riscos catastróficos que pudessem comprometer os equipamentos fabricados, porém somente com utilização dos mesmos na rotina de produção e o ciclo de melhoria continua dos equipamentos será possível validar este estudo prospectivo<br>In November 2005, with the guidance of the Quality Risk Management (Q9) the International Conference on Harmonization (ICH) in conjunction with regulatory agencies in the United States, Japan and Europe started recommending applying risk management for regulation of the pharmaceutical industry. Following this argument, the National Health Surveillance Agency (ANVISA) published the Board Resolution RDC 17/2010 which establish the Good Manufacturing Practices in Pharmaceutical Manufacturing, allowing the commercialization of pharmaceutical products. This resolution states to perform the production process validation on a risk analysis basis. Following the guidelines, this work intend to use the risk analysis tool Hazards and Operability Studies HAZOP in a bacterial bioreaction system for recombinant protein installed in Bio-Manguinhos/Fiocruz. This system consists of 100 (FE01) and 600 (FE02) liters fermenters, a harvest tank of 600 Liters (HT01) and a 600 Liters tank for culture media preparation (MT01). By applying, this tool was possible to classify the system risk identifying nodes, primary and secondary (deviations) guidewords, as well as, the severity and frequency of events. Thus, ones identified 82 risks within FE01 and FE02 fermenters, with 8.5% being irrelevant risks, 65.9% acceptable risks and 25.6% undesirable risks. In the harvest tank HT01 were identified 55 risks, which 14.5% are significant, 67.3% are acceptable and 18.2% undesirable. For media preparation tank, MT01 were identified 66 risks divided into 9% negligible risks,69.7% acceptable risks and 21.3% of unwanted risks. With these data, it is possible to ensure that there was not fatal risks that could harm the manufactured equipment, but only operation of this equipment during production routine and continual improvement cycle can validate this prospective study

ABSTRACT Glutaredoxins (Grxs) are glutathione-dependent oxidoreductases that belong to the so called Thioredoxin fold super-family, together with Thioredoxins (Trxs), Disulfide Oxidoreductases (Dsbs), Glutathione Transferases (GSTs), Peroxiredoxins (PRXs), Glutathione Peroxidases (GPXs) and Nucleoredoxins (NRXs). They are ubiquitous enzymes, being conserved throughout all the kingdoms of life from viruses to eukaryotes, and take part in a wide variety of biological processes. Grxs were first described as partners of ribonucleotide reductase (Holmgren A., 1976), a protein essential for the biosynthesis of deoxyribonucleotides, later on they were found to play a role in the reduction of dehydroascorbate to ascorbate, to be involved in the binding reactivation for some transcription factors to DNA and, in the case of Human Grx1, to be pivotal for the regulation of the activity of HIV-1 protease in vitro. Lately, an increasing number of papers point up the role of Grxs in the cellular iron homeostasis, since it was demonstrated their ability in building up, storing, and transferring [2Fe2S] type Iron Sulfur Clusters (ISCs), suggesting that Grxs are involved in the assembly of metalloproteins and/or act as Iron sensors (Rouhier et al., 2010). More in general, Glutaredoxins, together with the tripeptide glutathione (γ-glutamyl-cysteinyl-glycine) and Glutathione Reductase, are known to maintain the intracellular redox state, protecting the cell from reactive oxygen species (ROS) and modulating the reactivity of Cysteine-containing substrates through the formation or the reduction of disulfides bonds. Both intramolecular disulfide bonds between proteins as well as intermolecular bonds formed by a protein cysteinyl moiety and a low molecular weight thiol (also known as mixed disulphides) are typical substrates of this class of enzymes. From the structural point of view, Grxs are generally small, globular proteins (9-14 kDa) showing a highly conserved structural motif, the thioredoxin fold, that in its most simplified pattern consists of a four β-strand core surrounded by three α-helices. A first classification of Grxs into subclasses was done on the basis of the variability of the active site and their different biochemical behaviour (Herrero, E. et al., 2007): classical glutaredoxins v have in most cases a dithiol CP(Y/F)C active site, even if non-canonical C(S/G)(Y/F)C sequences were found, while a second distinct class was shown to contain a more conserved monothiol CGFS active site. Recently, comparative genomic analyses led to a further classification into six classes, being the first two classes the most important ones (Rouhier et al., 2010): class I collects all the single domain monothiol and dithiol Grxs in which a CPY[C/S], CGYC, CPFC or CSY[C/S] is found; class II contains all the highly conserved CGFS type Glutaredoxins, both single domain and multi domain fusion proteins. It was suggested though that single and multi domains Grxs should be put into distinct functional groups (Hoffmann, B.H. et al., 2010). The remaining classes are restricted to some particulare kingdoms (higher plants, eukaryotic photosynthetic organisms and cyanobacteria respectively). In this work we focused our attention on two monothiol glutaredoxins of Trypanosoma brucei, Tb-Grx1 and Tb-Grx3. Tripanosomatids are parasitical protozoa of the phylum Kinetoplastida and they're known to be the causative agents of some pathologies spread throughout the tropical areas of the South American (Chagas' disease) and African (Human sleeping sickness and Nagana cattle disease) continents. Trypanosomes encode three monothiol glutaredoxins: Grx1 and Grx2 are localized in the kinetoplast, the rudimentary mitochondrion-like organelle typical of flagellate protozoa, the former being a homodimeric protein found at a concentration as high as 5µM. On the contrary Grx3 is the only cytosolic monothiol glutaredoxin known for these organisms, and has the peculiarity of being a two-domain fusion protein, in which a C-terminal glutaredoxin is linked by a sequence of ten non conserved residues to a thioredoxin N-terminal domain (Filser, M. et al., 2008). In both Grx1 and Grx3 the active sites diverge from the typical conserved pattern described above for monothiol glutaredoxins, the former being characterized by a CAYS sequence and the latter by CGFT residues. The biochemical roles of these proteins are still under study, even if it is remarkable the lack of activity for Grx1 towards the common reduction assays, differently from Grx3 which is able to reduce both inter and intramolecular disulfide bridges; furthermore, in both cases, it was observed the reconstitution of [2Fe2S] ISCs in vitro. By solving the solution structures of these two enzymes and by studying the backbone dynamics via NMR, we aimed to shed light on their biochemical properties and more in general on their roles in the redox and Iron metabolism machineries of the Trypanosomatids. Moreover, since it was demonstrated that Tb-Grx1 is fundamental for the parasite survival vi (Manta, B. et al., unpublished), obtaining its structure is necessary in order to perform a structure driven drug discovery for the development of a new class of drugs targeting the diseases above mentioned. Finally, due to their peculiarities of being a homodimeric and a two-domain fusion protein respectively, the structural determination of Tb-Grx1 and Tb-Grx3 can be helpful in the classification of the glutaredoxins on the basis of their reactivity, their tertiary and, if present, quaternary structure. At the time of writing (January, 2012), there are only six either solution or crystal structures deposited in the Protein Data Bank identified as monothiol glutaredoxins, and all of them are known to be single-domain and monomeric proteins. To accomplish these aims, it was necessary to set up optimal strategies that take into account the supramolecular features unique to Tb-Grx1 and Tb-Grx3. Since the ab initio determination of the structure of a homodimer in solution can be cumbersome, a first simplification supported by preliminary biochemical experiments (Manta et al, unpublished) consisted on the study of the globular part of the protein and the putative dimerization domain as distinct moieties. The structure of the globular part of Grx1 was solved by the routine method exploiting nuclear Overhauser effect (NOE) derived distance restraints between couples of hydrogens. In particular, it was necessary to obtain a 13C-15N isotopically labeled protein in order to identify the resonance frequencies and to assign them respectively to the backbone and side-chains heteroatoms and to the amidic, aliphatic and aromatic hydrogens. For achieving this, the standard 3D backbone assignment experiments were used in their TROSY (Pervushin, K., et al, 1997) and BEST (Lescop, E. et al., 2007) variants, for improving spectral resolution and sensitivity but minimizing the acquisition time. The side-chains resonances and the NOE distance restraints used by the software Cyana (Herrmann, T. et al., 2002a and 2002b) for the structure calculation were obtained exploiting the standard 3D TOCSY and NOESY based experiments. The putative dimerization domain, consisting of 28 aminoacids, was instead obtained through chemical synthesis, and preliminarily studied via Circular Dichroism. To understand the modality of dimerization, its interaction with the Grx1 globular domain was studied observing and mapping the chemical shift perturbations from the 2D HSQC spectra of the 15N isotopically labeled protein. On the other hand, Tb-Grx3 is a two-domain 24 kDa protein, thus unsuitable for routinary NMR structure determination: NOE based distance restraints in the range of 1-5Å vii are both difficult to obtain in a relevant number from the crowded spectra that usually come together with a macromolecule of such a molecular weight and, even in the favorable case in which inter-domain distances were found, such restraints aren't sufficient to determine the mutual orientations of the domains, given that there are no internal dynamics involving the two moieties. For this reason we have developed a method for calculating a reasonable low resolution structure exploiting few and easy-to-acquire NMR-based experimental restraints, like backbone chemical shifts, from which it is possible to obtain the respective Ψ,Φ dihedral angles, and residual dipolar couplings (RDCs) that, by giving informations about the mutual orientations of couples of atoms, are thus the method-of-choice for determining the mutual orientation of the protein domains. In particular, the entire process was composed by a first step in which the two domains were obtained independently as isolated homology models and refined against the experimental data (Chou, J.J. et al., 2000), followed by a reconstitution of the whole protein and a rigid body docking (Schwieters, C.D. et al., 2010) driven by RDCs and Small Angle X-Ray Scattering (S.A.X.S.) curve analysis, thus providing at the same time both the domain mutual orientation and the shape of the whole macromolecule.<br>SOMMARIO Le Glutaredosine (Grxs) sono ossidoriduttasi glutatione-dipendenti che appartengono alla super-famiglia strutturalmente caratterizzata dal cosiddetto “Thioredoxin-fold”. A questa famiglia appartengono, oltre alle tioredossine, anche le disolfuro-ossidoriduttasi bisolfuro (DsBs), le glutation-transferasi (GST), le perossiredossine (PRX), le glutation-perossidasi (GPXs) e le nucleoredossine (NRXs). Tutte queste proteine sono enzimi ubiquitari, conservati in tutti i regni viventi, dai virus agli eucarioti e prendono parte a una vasta gamma di processi biologici. Le glutaresossine sono state inizialmente descritte come partner della ribonucleotide reduttasi (Holmgren A., 1976), una proteina essenziale per la biosintesi di deossiribonucleotidi e in seguito è stato dimostrato che esse svolgono un ruolo nella riduzione di deidroascorbato ad ascorbato, nella riattivazione del legame al DNA per alcuni fattori di trascrizione. La GRX1 umana è inoltre fondamentale per la regolamentazione dell'attività di proteasi dell'HIV-1 in vitro. Ultimamente, un numero crescente di articoli pubblicati in letterarura ha messo in luce il ruolo di Grxs nell'omeostasi del ferro cellulare, dimostrandola loro abilità nel costruire, conservare e trasferire cluster ferro zolfo (ISC) di tipo [2Fe2S], suggerendo quindi che le Grxs sono probabilmente coinvolte nell'assemblaggio di metalloproteine e/o agiscono come sensori del ferro (Rouhier et al., 2010). Più in generale,le glutaredossine insieme al tripeptide glutatione (γ-glutamil-cisteinil-glicina) ee alla glutatione-reduttasi, sono note per mantenere lo stato redox intracellulare, proteggendo la cellula da specie reattive dell'ossigeno (ROS) e modulando la reattività di substrati contenenti cisteina, attraverso la formazione o la riduzione di legami disolfuro. Possono essere substrati di questa classe di enzimi sia i ponti disolfuro intramolecolari nelle proteine sia i legami intermolecolari formati dalle cisteine di una proteina con un tiolo a basso peso molecolare (disolfuri misti). Dal punto di vista strutturale, le Grxs sono generalmente piccole proteine globulari (9-14 kDa) caratterizzate da un motivo strutturale altamente conservato (thoredoxin-fold) che nel suo modello più semplice è costituito da un β-foglietto a 4 filamenti circondato da tre α-eliche. Una prima classificazione delle Grxs in sottoclassi è stata fatta sulla base della variabilità del sito attivo e del loro diverso comportamento biochimico (Herrero, E. et al, 2007.): le glutaredoxins classiche hanno in molti casi un sito attivo ditiolico CP(Y/F) C , i anche se sono stati riscontati casi con una sequenza non-canonica C(S/G)(Y/F)C, mentre una seconda classe distinta contiene un sito attivo monotiolico altamente conservato CGFS. Recentemente, l’analisi genomica comparativa ha portato ad un'ulteriore classificazione in sei classi, essendo le prime due classi più importanti (REF):la classe I raccoglie tutte le Grxs a singolo dominiocon sito attivo monotiolico e ditiolico di tipo CPY[C/S], CGYC, CPFC or CSY[C/S], la classe II contiene tutte le glutaredossine con sito attivo altamente conservato CGFS, sia a singolo dominio come proteine di fusione multidominio. È stato tuttavia suggerito che le Grxs a dominio singolo o multiplo dovrebbero essere messe in distinti gruppi funzionali (Hoffmann, BH et al., 2011). Le classi rimanenti sono limitati ad alcuni regni particulari (piante superiori, organismi fotosintetici eucarioti e cianobatteri, rispettivamente). In questo lavoro, la nostra attenzione è stata rivolta a due glutaredossine monotioliche di Trypanosoma brucei, Tb-Grx1 e Tb-Grx3. I tripanosomatidi sono protozoi parassiti del phylum Kinetoplastida e sono noti per essere gli agenti che causano alcune patologie diffuse in tutte le aree tropicali del Sudamerica (malattia di Chagas) e dell’Africa (in particolare la malattia del sonno umana ed una patologia bovina chiamata nagana). I tripanosomi codificano tre glutaredosine monotioliche: Grx1 e Grx2 sono localizzate nei cinetoplasti, i rudimentali mitocondri tipici di protozoi flagellati; la prima è una proteina omodimerica trovata ad una concentrazione fino a 5 M. Grx3 è invece l’unica glutaredossina monotiolica presente nel citosol di questi organismi ed ha la particolarità di essere una proteina di fusione costituita da due domini, in cui una glutatedossina C-terminale è unita mediante una sequenza di dieci residui non conservati ad una tioredoxina N-terminale (Filser, M. et al., 2008). Sia in Grx1 che in Grx3 i siti attivi divergono dal modello tipico conservato, sopra descritto per le glutaredossine monotioliche, il primo è caratterizzato infatti da una sequenza CAYS e il secondo dai residui CGFT. I ruoli biochimici di queste non sono ancora noti, anche se è è da segnalare l'assenza di attività per GRX1 nei comuni test di attività ossidoriduttasica, a differenza di Grx3 che è in grado di ridurre sia l'altro e ponti disolfuro intramolecolari, inoltre. Entrambe le proteine sono in grado di formare in vitro cluster ferro zolfo di tipo [2Fe2S]. Lo scopo di questo lavoro è quello di fornire delle informazioni sulle proprietà biochimiche e più in generale e più in generale sul loro ruolo nel metabolismo redox e sul metabolismo del ferro nei Tripanosomatidi attraverso lo studio mediante NMR della struttura e dinamica in soluzione di questi due enzimi. Inoltre, poiché è stato dimostrato che la Tb-Grx1 è fondamentale per la sopravvivenza del parassita (Manta, B. et al., comunicazione personale), le informazioni strutturali ottenute possono essere utili per sviluppo di nuovi farmaci destinati ii alle malattie menzionate in precedenza. Infine, per la loro peculiarità di essere rispettivamente un omodimero ed una proteina di fusione a due domini, gli studi strutturali su Tb-Grx1 e Tb-Grx3 possono essere utili per la classificazione delle glutaredossine sulla base della loro reattività, la loro terziario e, se presente, struttura quaternaria. Ad oggi (gennaio 2012), ci sono solo sei strutture identificate come glutaredossine monotioliche depositate nel Protein Data Bank, e tutte sono relative aproteine a proteine a singolo dominio e monomeriche. Per realizzare questi obiettivi, sono state messe a punto dellestrategie ottimali per tenere conto delle caratteristiche supramolecolare unica di Tb-GRX1 e Tb-Grx3. Dal momento che la determinazione della struttura di un omodimero in soluzione può essere molto complessa, una prima semplificazione, supportata da esperimenti biochimici (Manta et al, inedito) è consistita sullo studio della parte globulare della proteina Grx1, separata dal suo putativo dominio di dimerizzazione.La struttura della parte globulare di Grx1 è stata risolta con il metodo di classico sfruttando l’effetto nucleare Overhauser (NOE) per ottenere una serie didistanze tra coppie di atomi di idrogeno. Per fare ciò è stato necessario per ottenere la proteina isotopicamente marcata con 13C e 15N al fine di poter acquisire gli esperimenti NMR multidimensionali per realizzare l’assegnazione sequenziale delle frequenze di risonanza degli atomi in catena principale e nelle catele laterali. Per raggiungere questo scopo sono state utilizzate le tradizionali sequenze eteronucleari 3D implementate tuttavia in modalità TROSY (Pervushin, K., et al, 1997) e BEST (Lescop, E. et al., 2007) , per migliorare la risoluzione spettrale e la sensibilità, ma riducendo al minimo il tempo di acquisizione. Le risonanze delle catene laterali ed i vincoli di distanza NOE utilizzati dal software Cyana (Herrmann, T. et al., 2002a e 2002b) per il calcolo della struttura sono stati ottenuti rispettivamente mediante esperimenti 3D-TOCSY e 3D-NOESY. Il putativo dominio di dimerizzazione, composto di 28 aminoacidi, è stato invece ottenuto attraverso sintesi chimica e studiato preliminarmente tramite dicroismo circolare. Per verificare una sua possibile interazione con il dominio globulare di Grx1 sono stati eseguiti eseperimenti di tipo 2D HSQC sulla proteina marcata con 15N, assenza ed in presenza del peptide stesso. Tb-Grx3 al contrario consiste in una proteina di 24kDa composta da due domini, e per questo motivo risulta inadatta per una determinazione strutturale standard via NMR. : vincoli di distanza basati sull'effetto NOE dell'ordine dei 1-5A sono sia ostici da ottenere in un numero rilevante, a causa del fatto che all'aumentare delle dimensioni molecolari aumenta significativamente il numero dei segnali, sia inefficienti nel determinare la mutua orientazione tra i domini, ammesso che non vi siano dinamiche interne che coinvolgono le due parti. iii Per questa ragione abbiamo sviluppato un metodo per calcolare strutture ragionevoli a bassa risoluzione che sfruttano pochi vincoli sperimentali facili da acquisire, quali gli angoli diedri ricavabili dai chemical shifts del backbone e i residual dipolar couplings che danno informazione sulla mutua oorientazione di coppie di atomi, e ch eper questo motivo sono il metodo d'elezione per studi di questo genere. In particolare, la procedura completa è composta da un primo step in cui i due domini vengono ricavati per mezzo di homology modeling e successivamente soggetti a refinement con i dati sperimentali a disposizione (Chou et al., 2000) seguito da una fase di docking (Schwieters et al., 2010) guidato dagli RDC e dall'analisi della curva di Small Angle X-ray Scattering, in modo tale da garantire sia una corretta orientatazione che la compattezza della molecola

Pourquoi la République démocratique du Congo (RDC), depuis son indépendance jusqu'à ce jour, se trouve dans un état de guerre permanente? Notre étude sur cette crise congolaise, l'une des plus grave que connaît la planète en ce début du XXIème siècle, tente de comprendre les causes et les significations de sa pérennisation. La faillite de l'Etat congolais a conduit à l'invasion, à l'occupation et au pillage de ses ressources naturelles par différents types d'acteurs (étatiques et individuels, nationaux et étrangers). Cette recherche a pour ambition de mettre en lumière les principales dynamiques contradictoires qui n'ont pas permis particulièrement à deux systèmes politico-militaires de pouvoir, "mobutiste" et "kabiliste", alliés des mafias internationales, de créer les conditions d'émergence d'un véritable Etat autonome dans lequel se reconnaît la population. L'Etat post-colonial est, de manière récurrente, producteur d'un conflit de type armé qui s'est aujourd'hui internationalisé. Toute tentative de solution à cette crise permanente se doit de tenir compte à la fois des éléments internes et externes. Sans la prise en compte de cette approche globale, la RDC, déjà avec un chiffre de près de quatre (4) millions de morts (souce ONU), court simplement le risque de fragmentation spatiale et de récupération par des Organisations criminelles internationales. Ce défi à relever exige une réelle volonté politique de la part de tous les acteurs tant nationaux qu'étrangers pour asseoir une paix efficace et durable, en vue de sortir la République de cette épreuve difficile.

Les Banyarwanda au Nord-Kivu (Congo) représentent 50 % de la population de cette province. Ces populations transfrontalières a cheval sur Ie Rwanda et Ie Bufumbira ougandais se retrouvent de façon récurrente au cœur du débat congolais autour non seulement de la question de la nationalité mais aussi de leur intégration politique et économique dans Ie contexte d'un Congo en mutation profonde. La décision de créer de nouvelles entités administratives en 1962 fut la pomme de discorde qui divisa les élus du Kivu. Les guerres successives au Nord-Kivu depuis l'indépendance, ainsi que les lois successives sur la nationalité qui ont fait les populations Banyarwanda des apatrides depuis 1981, puisent leur virulence dans I' opposition entre « autochtones» et« allogènes ». Dans cette thèse nous démontrons que la qualification Banyarwanda recouvre des situations historiques et sociales complexes. Les logiques de profits imposées par les capitaux prives investis par les entreprises coloniales ont exacerbe la complexité de la question des Banyarwanda. A défaut d'un Etat congolais capable d'imposer une régulation politique, les Banyarwanda (d'origine congolaise et immigres confondus) se retrouvent en définitive des citoyens constamment en sursis.

La présente recherche examine la couverture médiatique du conflit armé qui a opposé les Forces armées de la RDC à la rébellion du 23 mars dans la province du Nord Kivu, entre mai 2012 et novembre 2013. Au regard des stratégies diverses d’enrôlement des médias et de contrôle des contenus journalistiques mises en place par les belligérants, (pressions, intimidations, séductions, menaces, etc.), la thèse s’intéresse, en particulier, à la manière dont ces différents facteurs propres au système médiatique congolais ou générés par le contexte spécifique de ce conflit ont déterminé la construction des récits journalistiques diffusés par des radios locales, nationales et internationales sur le déroulement de cette guerre. Il s’est agi de voir les contenus journalistiques auxquelles les auditeurs congolais ont été confrontés et de cerner les dynamiques et logiques qui ont conduit à leur élaboration. L’étude s’appuie sur une démarche triangulatoire qui a permis d’analyser, de manière complémentaire, deux types de matériaux :des corpus radiophoniques, prélevés auprès d’un échantillon de cinq radios (Kivu One et VBR de Goma, Top Congo FM et Radio Okapi de Kinshasa, RFI émettant depuis Paris) et des entretiens semi-directifs réalisés avec dix-neuf journalistes, explorant les conditions dans lesquelles les récits diffusés ont été produits. Elle croise un axe géographique, les implantations des médias étudiés étant différentes, et un axe diachronique, en se focalisant sur trois phases distinctes (début, milieu et fin du conflit). L’examen effectué sur le corpus radiophonique a mis en lumière l’existence d’une multiplicité des pratiques journalistiques que la recherche s’est attachée à qualifier :journalisme « surveillé », « assiégé », « occupé », « effacé », « embarqué », « distancié », « patriotique », « de paix », « du vainqueur » « de communication » … Les entretiens ont permis de mieux comprendre les déterminants qui ont conduit les journalistes à ces pratiques, c’est-à-dire un ensemble de facteurs, ancrés à la fois dans l’environnement sociétal, dans des dynamiques internes aux entreprises médiatiques, dans des commodités professionnelles ou dans des expériences personnelles de vie. L’analyse combinée des récits journalistiques diffusés et des discours des journalistes actualise, dans le contexte congolais, un ensemble d’interrogations portant sur la couverture journalistique des conflits :tension entre responsabilité professionnelle et responsabilité citoyenne ;limitations liées aux moyens disponibles et aux conditions sécuritaires ;poids des connexions financières ou politiques au sein des rédaction ;interventions directes des belligérants dans le secteur médiatique ;possibilité et modalités de la neutralité du journaliste, en particulier lorsque ce dernier est originaire du pays en conflit et qu’il réside dans la région où se déroulent les combats. Journalistes et radios ayant développé des réponses pratiques différenciées à ces interrogations, la thèse en souligne et examine l’impact sur les récits médiatiques diversifiés proposés au public congolais.<br>Doctorat en Information et communication<br>info:eu-repo/semantics/nonPublished

Realiza un estudio de tipo descriptivo y transversal con el propósito de relacionar la alteración postural de cabeza y cuello con los desórdenes temporomandibulares (DTM). Se seleccionó de manera no probabilística y por conveniencia a 30 internos de Odontología de la promoción 2011 del Hospital Nacional Dos de Mayo, cuyas edades comprendieron desde 21 a 30 años, de ambos géneros (14 mujeres y 16 hombres). Se realizó la anamnesis, el examen clínico según el Eje I de los Criterios Diagnóstico de Investigación en Desórdenes Temporomandibulares (RDC/TMD) para hallar la presencia de Desórdenes Temporomandibulares y el análisis radiográfico a través del Cefalograma descrito por Rocabado. Los datos fueron procesados mediante la prueba de Significancia Estadística no paramétrica CHI cuadrado (x2), este análisis estadístico se realizó con el programa spss 17.0. Los resultados mostraron que los sujetos no presentaron Disfunción Muscular. Al relacionarse la Disfunción Articular con: la alteración de la distancia Occipital-Atlas (OA), el ángulo Anteroposterior (API) y el Triángulo Hioideo (TH) no se encontró asociación estadística. Se concluye que la alteración postural de cabeza y cuello no se relaciona con la presencia de Desórdenes Temporomandibulares.<br>Tesis

Realiza un estudio de tipo descriptivo y transversal con el propósito de relacionar la alteración postural de cabeza y cuello con los desórdenes temporomandibulares (DTM). Se seleccionó de manera no probabilística y por conveniencia a 30 internos de Odontología de la promoción 2011 del Hospital Nacional Dos de Mayo, cuyas edades comprendieron desde 21 a 30 años, de ambos géneros (14 mujeres y 16 hombres). Se realizó la anamnesis, el examen clínico según el Eje I de los Criterios Diagnóstico de Investigación en Desórdenes Temporomandibulares (RDC/TMD) para hallar la presencia de Desórdenes Temporomandibulares y el análisis radiográfico a través del Cefalograma descrito por Rocabado. Los datos fueron procesados mediante la prueba de Significancia Estadística no paramétrica CHI cuadrado (x2), este análisis estadístico se realizó con el programa spss 17.0. Los resultados mostraron que los sujetos no presentaron Disfunción Muscular. Al relacionarse la Disfunción Articular con: la alteración de la distancia Occipital-Atlas (OA), el ángulo Anteroposterior (API) y el Triángulo Hioideo (TH) no se encontró asociación estadística. Se concluye que la alteración postural de cabeza y cuello no se relaciona con la presencia de Desórdenes Temporomandibulares.<br>Tesis

Dissertação (mestrado)—Universidade de Brasília, Faculdade de Ciências da Saúde, Programa de Pós-Graduação em Ciências da Saúde, 2012.<br>Submitted by Tania Milca Carvalho Malheiros (tania@bce.unb.br) on 2012-10-10T19:10:05Z No. of bitstreams: 1 2012_NatáliaCardosoSantos_Parcial.pdf: 1526097 bytes, checksum: bd91401ac9dec563b91f1727d8fde222 (MD5)<br>Approved for entry into archive by Jaqueline Ferreira de Souza(jaquefs.braz@gmail.com) on 2012-10-11T13:54:25Z (GMT) No. of bitstreams: 1 2012_NatáliaCardosoSantos_Parcial.pdf: 1526097 bytes, checksum: bd91401ac9dec563b91f1727d8fde222 (MD5)<br>Made available in DSpace on 2012-10-11T13:54:25Z (GMT). No. of bitstreams: 1 2012_NatáliaCardosoSantos_Parcial.pdf: 1526097 bytes, checksum: bd91401ac9dec563b91f1727d8fde222 (MD5)<br>Receptores nucleares, tais como PPAR, GR, TR, ER e PXR, estão relacionados a diversos processos biológicos. Diversos ligantes sintéticos e naturais possuem a capacidade de ativá-los ou reprimi-los influenciando diretamente sua maquinaria transcricional. O receptor de pregnanos X (PXR), em especial, exerce função crucial na homeostase de metabolização e eliminação de endobióticos e xenobióticos por meio da regulação de enzimas do citocromo P450, especialmente a CYP3A4. A utilização concomitante de fármacos, ou desses, com determinados tipos de alimentos ou fitoterápicos que apresentem agonismo ou antagonismo com receptores nucleares, pode interferir na terapêutica. No Brasil, desde 2006, a prática da Fitoterapia no Sistema Único de Saúde (SUS) tem sido incentivada com a inserção de fitoterápicos na Relação de Medicamentos Essenciais e com a publicação de diversas normas sanitárias, regulando o setor. Uma dessas normas, publicada em 2010, refere-se a drogas vegetais e em seu anexo há uma lista de 66 espécies vegetais com a respectiva indicação terapêutica e posologia. A presente dissertação teve por objetivo avaliar os efeitos agonistas no receptor de pregnanos X (PXR) de nove espécies contidas na RDC 10/10 da Anvisa. Das espécies vegetais foram obtidos extratos os quais foram avaliados quanto a suas toxicidades pelo método do MTT e em seguida submetidos a ensaios de gene repórter a fim de avaliar seus efeitos na maquinaria transcricional do PXR. Os resultados do ensaio de gene repórter com o extrato de Achyrocline satureioides (macela) sugerem uma ação agonista dose-dependente no PXR, o que não aconteceu com as outras drogas vegetais estudadas. Não houve efeito agonista do extrato de A. satureioides nos receptores TRbeta e PPAR gama. Este trabalho constitui-se como base prospectiva para o aprofundamento do estudo da própria A. satureioides, no possível isolamento e identificação de seus compostos ativos, seus efeitos sobre enzimas que metabolizam xenobióticos, especialmente CYP3A4, bem como, para estudos de outras drogas vegetais constantes na RDC 10/10, visando assegurar o uso seguro e eficaz dessas espécies pela população. ______________________________________________________________________________ ABSTRACT<br>Nuclear receptors such as PPAR, GR, TR, ER and PXR, are related to diverse biological processes. Several natural and synthetic ligands have the ability to activate or repress them directly influencing their transcriptional machinery. The pregnanes X receptor (PXR), in particular, plays critical role in homeostasis, metabolism and excretion of xenobiotics and endobiotics through the regulation of P450 enzymes, especially CYP3A4.The concomitant use of drugs, or those, with certain types of food or herbal remedies that have agonism or antagonism with nuclear receptors, may interfere with therapy. In Brazil, since 2006, the practice of Herbal Medicine in Unified Health System (SUS) has been encouraged with the inclusion of herbal medicines in the List of Essential Medicines and the publication of several health conditions, regulating the industry. One of these standards, published in 2010, refers to herbal drugs and its attachment 66 is a list of plant species with the therapeutic indication and its dosage. The aim of this study was to evaluate the effects of receptor agonists in PXR from nine species contained in the RDC 10/10 of The National Health Surveillance Agency (Anvisa). From the plant species were obtained extracts which were evaluated for their toxicity by the MTT method and then tested for reporter gene to assess its effects on the transcriptional machinery of the PXR. The results of the reporter gene assay with the extract of Achyrocline satureioides (macela) suggest a dose-dependent agonist in PXR, which did not happen with other herbal drugs studied. There was no agonist effect of the extract of A. satureioides TR beta receptors and PPAR gamma. This work constitutes itself as a prospective basis for further studies on A. satureioides, possible isolation and identification of its active compounds, their effects on xenobiotic metabolizing enzymes, particularly CYP3A4, as well as, for studies of other drug plants listed in the RDC 10/10, to ensure the safe and effective use of these species by the population.

Dissertação (mestrado)—Universidade de Brasília, Faculdade de Arquitetura e Urbanismo, Programa de Pesquisa e Pós-graduação, 2014.<br>Submitted by Ana Cristina Barbosa da Silva (annabds@hotmail.com) on 2015-04-24T16:04:14Z No. of bitstreams: 1 2014_OsvaldoTelmoMelgaresLobo.pdf: 3893336 bytes, checksum: 727720144e42d46ce2bb1ddc25845d4f (MD5)<br>Approved for entry into archive by Guimaraes Jacqueline(jacqueline.guimaraes@bce.unb.br) on 2015-05-04T13:26:26Z (GMT) No. of bitstreams: 1 2014_OsvaldoTelmoMelgaresLobo.pdf: 3893336 bytes, checksum: 727720144e42d46ce2bb1ddc25845d4f (MD5)<br>Made available in DSpace on 2015-05-04T13:26:26Z (GMT). No. of bitstreams: 1 2014_OsvaldoTelmoMelgaresLobo.pdf: 3893336 bytes, checksum: 727720144e42d46ce2bb1ddc25845d4f (MD5)<br>Os desastres, naturais ou antrópicos, ocasionam intensos danos às comunidades, exigindo que seus serviços de saúde continuem operando para proteger a vida da população. O funcionamento ininterrupto dos serviços de saúde define, nestes casos, o limite entre a vida e a morte, tornando-se imperativo que as edificações que abrigam os serviços de saúde sejam resistentes à força destrutiva dos desastres. Na iniciativa EAS/Hospital Seguro Frente a Desastres, desenvolvida pela OPS/OMS para redução dos riscos na infraestrutura física e operacional, é imperativo que a edificação seja capaz de garantir o seu funcionamento eficiente durante e após um desastre. Considerando que, atualmente, no Brasil, a política do EAS/Hospital Seguro começa a ser promovida como parte integrante do planejamento de redução dos riscos de desastres no setor saúde, é objetivo desta Dissertação levantar os critérios de seleção estabelecidos pela OPS/OMS para os dezoito elementos arquitetônicos (como variáveis de avaliação da segurança não estrutural) e indagar se as Resoluções Sanitárias elaboradas pela ANVISA (relacionadas à qualidade da infraestrutura física dos EAS/hospitais) apresentam instrumentos, ferramentas e mecanismos que buscam a redução da vulnerabilidade e, como consequência, a minimização dos potenciais danos decorrentes de desastres. Com base na revisão bibliográfica, foram levantados os dezoito elementos arquitetônicos e analisados seus critérios de seleção; da mesma forma que foram levantados e analisados os instrumentos, ferramentas e mecanismos presentes nas Resoluções Sanitárias, que tratam da redução da vulnerabilidade não estrutural referente aos elementos arquitetônicos. Os resultados mostraram que o arcabouço da regulação sanitária desenvolvida pela ANVISA/MS no Brasil não considera, ainda, no seu escopo de Resoluções Sanitárias referentes à infraestrutura física, aspectos específicos concernentes à iniciativa EAS/Hospital Seguro e, mais pontualmente, a aspectos de redução da vulnerabilidade não estrutural referentes aos elementos arquitetônicos. Buscando contribuir com as iniciativas da OPS/OMS e da ANVISA/MS para a melhoria da segurança da infraestrutura física de saúde, e no intuito de agregar valor aos instrumentos específicos que facilitam o monitoramento dos EAS/hospitais nos seus componentes de infraestrutura física, propõem-se duas diretrizes que complementam as ações em andamento na GRECS/GGTES/ANVISA/MS, no sentido de atualizar tecnicamente dois temas específicos no âmbito da regulamentação para projetos físicos de EAS/hospitais. São elas: Elaboração de manual sobre a “Redução da Vulnerabilidade das Edificações de Saúde no Enfrentamento de Situações de Desastres: a segurança não estrutural – os elementos arquitetônicos” como objetivo de um sexto tema denominado “Redução da Vulnerabilidade das Edificações de Saúde”, a ser desenvolvido na modalidade TR – OPS/OMS/ANVISA; e Inclusão de Capítulo específico no Processo de Revisão da RDC nº 50/2002 (regulamentação técnica para o planejamento, programação e projeto de EAS/hospital) sobre a redução da vulnerabilidade das edificações de saúde. _________________________________________________________________________________ ABSTRACT<br>Disasters, natural or man-made, cause intense damage to communities requiring health services continue operating to protect the lives of the population. The uninterrupted operation of health services defines, in these cases, the boundary between life and death, making it imperative that the buildings that house the health services are resistant to the destructive force of disasters. In the EAS/Hospital safety initiative against disasters, developed by OPS/OMS for reduction of risks on physical infrastructure and operational, it is imperative that the building is able to ensure its efficient functioning during and after a disaster. Whereas currently in Brazil the EAS/Hospital safety policy starts to be promoted as an integral part of the planning for disaster risk reduction in the health sector, is the goal of this dissertation raise the selection criteria established by the OPS/OMS for the eighteen architectural elements (while not security evaluation variables structural) and inquire if Health Resolutions drawn up by ANVISA (related to the quality of the physical infrastructure of the EAS/Hospital) present instruments, tools and mechanisms that seek to reduce vulnerability and to minimize the potential damage from disasters. Based on the literature review have been raised eighteen architectural elements and analyzed their selection criteria; in the same way have been collected and analyzed the instruments, tools and mechanisms presents in Health Resolutions that deal with the reduction of structural vulnerability relating to architectural elements. The results showed that the sanitary regulation framework developed by ANVISA/MS in Brazil does not consider, even, in their scope of Sanitary Resolutions pertaining to physical infrastructure, specific aspects concerning the safe and EAS/Hospital initiative more promptly to aspects of reduction of structural vulnerability relating to architectural elements. Seeking to contribute to the initiatives of OPS/OMS and ANVISA/MS for improving the physical infrastructure of health security, and in order to add value to specific instruments that facilitate the monitoring of EAS/hospital in their physical infrastructure components, we propose two guidelines that complement ongoing actions on GRECSG/GTES/ANVISA/MS in order to upgrade technically two specific themes under the rules for physical projects of EAS/hospital, they are: Preparation of manual on the "Reduction of the vulnerability of Health-care facilities Confronting disaster situations: the structural safety-architectural elements" while aiming at a sixth theme named "Reducing the vulnerability of Health-care facilities", to be developed in TR-OPS/OMS/ANVISA; and Inclusion of a specific Chapter in the process of revision of the RDC nº. 50/2002 (technical regulations for planning, programming and project of EAS/hospital) on reducing the vulnerability of health-care facilities.

Cette thèse part de la constatation que la conversion au christianisme des Nande dans le diocèse de Butembo-Beni au Congo-Kinshasa (RDC) s’est accompagnée d’une profonde transformation sociale, culturelle et religieuse. Cette adhésion à la nouvelle religion a été rendue possible par le fait que le christianisme est perçu comme porteur de nouvelles valeurs humaines, spirituelles et matérielles, et sert au progrès et au développement de la personne. La recherche examine le processus de cette transformation. Elle fut le résultat des confrontations et de malentendus, d’échanges et d’appropriations. Elle a abouti à une forme d’acculturation religieuse qui suppose des ruptures et assure une continuité culturelle. Elle a conduit à une « réorientation » de la vie des Nande qui trouvent dans ce processus des raisons d’être et de vivre et contribue à la construction d’une nouvelle identité, individuelle ou collective. Elle entraîne de nouveaux problèmes nés de la christianisation de la majorité de la population. This thesis is based on the observation that the conversion of Nande of the diocese of Butembo-Beni in Congo-Kinshasa (DRC) was accompanied with a deep social, cultural and religious transformation. That adhesion to a new religion has been possible by the fact that the christianism has been forseen as carrier of new human, spiritual and material values for the progress and the developpement of human being. This research analyses the process of that transformation which is the relultat of confrontations and misunderstanding, exchanges and appropriation. It occurred a kind of “religious acculturation” which implies rupture and cultural continuity. It led to a “reorientation” of the life of Nande who find in that process new reasons of being and living. This fact contributes to the construction of their new identity, individualy and communautary. Nevertheless, adhesion to christianity generated new social and religious problems.

La compréhension de l'apport du rôle des termites sur le transport des métaux d'intérêt économique au sein de l'ensemble lithosphère - pédosphère - termitières, se révèle d'un grand intérêt pour une caractérisation géochimique et géologique d'anomalies en prospection minière. En effet, les termites jouent un rôle fonctionnel remarquable dans la structuration des sols, entrainant des enrichissements chimiques liés au transport vertical de minéraux, échangés entre les horizons situés en profondeur et les termitières érigées en surface. Cette thèse a pour objectif de mettre en lumière l'impact des termites sur les cycles biogéochimiques du Cu et du Co dans une région potentiellement riche en ressources minérales (Katanga, RDC), dans un objectif d'utilisation optimisée des termitières en prospection minière. Cette objectif requiert une caractérisation des phases minérales et organiques à diverses échelles. Pour y parvenir, il a été question en premier lieu, de faire une cartographie géochimique des termitières de deux genres dominants de la région, Macrotermes et Cubitermes, à l'échelle paysagère sur une zone ayant fait l'objet d'une cartographie géologique et géochimique sur sols et roches. Cette cartographie a permis de mettre en évidence à l'échelle régionale des faciès lithogéochimiques traduisant la géologie des formations sous-jacentes et ce en fonction des habitudes alimentaires de chaque genre de termite. La distribution spatiale des termitières a également permis de suivre l'évolution des teneurs en Cu et Co au sein des termitières en fonction de la géologie de la zone d'étude. La combinaison des données acquises sur la constitution minéralogique et géochimique des matériaux constituant les termitières de Macrotermes falciger et la caractérisation morphologique et chimique de leurs principaux constituants à l'échelle microscopique a permis l'identification des phases porteuses des métaux d'intérêts dans les matériaux de ces termitières. De même la comparaison de la signature géochimique des termitières de M. falciger et de leurs matériels parentaux a permis d'établir un lien lithogéochimique, identifiant ainsi la source d'approvisionnement en profondeur utilisée par les individus de M. falciger. Enfin, la conjugaison de résultats d'une part sur la caractérisation géochimique de quatre fractions granulométriques (0-20 µm ; 20-63 µm ; 63-200 µm ; 200-2000 µm) des termitières et d'autre part sur l'évaluation de l'impact des termites sur la constitution d'agrégats dans les termitières et/ou sols, a permis de préciser les fractions granulométriques les plus informatives sur la présence et la minéralisation des phases porteuses des métaux d'intérêt du Katanga dans les matériaux de termitières. L'application de toutes ces méthodes et tous les éléments recueillis ont permis de proposer un schéma des cycles biogéochimiques de Cu et Co dans ce système soulignant l'utilisation des termitières en prospection minière efficace et efficiente<br>Knowledge of the influence of termites on transport of metals of economic interest within the complex of lithosphere, pedosphere and termite mounds is of great interest for geochemical and geological characterization of anomalies in mining prospection. Termites have an important functional role in the structuring of soils, causing chemical enrichment through the vertical transport of minerals exchanged between the deeper horizons and the termite mounds built at the surface. Our objective in this thesis is to evaluate the influence of termites on Cu and Co biogeochemical cycles in a mineral-rich region (Katanga, DRC), with the aim to optimize the utilization of termite mounds in mining prospection. This objective requires a characterization of mineral and organic phases at various scales. To achieve this, firstly, a geochemical mapping of termite mounds of two dominant genera of the region, Macrotermes and Cubitermes, was carried out at the landscape scale in an area that received a geological and soil and rock geochemical mapping. The utilization of termite mounds allowed the identification of lithogeochemical facies reflecting the subjacent geology on a regional scale according to the feeding habits of each termite genus. The spatial distribution of termite mounds also allowed us to follow Cu and Co content evolution according to study area geology. The combination of mineralogical and geochemical data acquired on Macrotermes falciger termite mounds and morphological and chemical characterization of their main constituents at microscopic scale allowed to identify carrier phases of interest metals in termite mounds materials. Similarly, the comparison of geochemical signatures of M. falciger termite mounds and their parent materials allowed to establish a lithogeochemical relationship, identifying the source of provisioning at depth by M. falciger. Finally, the association of geochemical characterization results of termite mounds for four granulometric fractions (0-20 µm; 20-63 µm; 63-200 µm; 200-2000 µm) and results on evaluation of the impact of termites on the constitution of aggregates in termite mounds and/or soils, allowed to specify the most informative granulometric fractions on the presence and mineralization of carrier phases of interest metals in Katanga in termite mound materials. The application of all these methods and all elements collected allowed us to propose a Cu and Co biogeochemical cycle scheme in this system, underlying the use of termite mounds in effective and efficient mining prospection