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Littérature scientifique sur le sujet « Receptor-ligand complexes »

Auteur : Grafiati

Publié le 4 juin 2021

Mis à jour le 26 juillet 2024

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Articles de revues sur le sujet "Receptor-ligand complexes"

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Veeramani, Suresh, and George J. Weiner. "Quantification of Receptor Occupancy by Ligand—An Understudied Class of Potential Biomarkers." Cancers 12, no. 10 (October 13, 2020): 2956. http://dx.doi.org/10.3390/cancers12102956.

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Molecular complexes, such as ligand–receptor complexes, are vital for both health and disease and can be shed into the circulation in soluble form. Relatively little is known about the biology of soluble ligand–receptor complexes. The functional importance of such complexes and their potential use as clinical biomarkers in diagnosis and therapy remains underappreciated. Most traditional technologies used to study ligand–receptor complexes measure the individual levels of soluble ligands or receptors rather than the complexes themselves. The fraction of receptors occupied by ligand, and the pot

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Guvench, Olgun, Daniel J. Price, and Charles L. Brooks. "Receptor rigidity and ligand mobility in trypsin-ligand complexes." Proteins: Structure, Function, and Bioinformatics 58, no. 2 (December 1, 2004): 407–17. http://dx.doi.org/10.1002/prot.20326.

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Särndahl, E., M. Lindroth, T. Bengtsson, M. Fällman, J. Gustavsson, O. Stendahl, and T. Andersson. "Association of ligand-receptor complexes with actin filaments in human neutrophils: a possible regulatory role for a G-protein." Journal of Cell Biology 109, no. 6 (December 1, 1989): 2791–99. http://dx.doi.org/10.1083/jcb.109.6.2791.

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Most ligand-receptor interactions result in an immediate generation of various second messengers and a subsequent association of the ligand-receptor complex to the cytoskeleton. Depending on the receptor involved, this linkage to the cytoskeleton has been suggested to play a role in the termination of second messenger generation and/or the endocytic process whereby the ligand-receptor complex is internalized. We have studied how the binding of chemotactic peptide-receptor complexes to the cytoskeleton of human neutrophils is accomplished. As much as 76% of the tritiated formylmethionyl-leucyl-

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Suthaus, Jan, Anna Tillmann, Inken Lorenzen, Elena Bulanova, Stefan Rose-John, and Jürgen Scheller. "Forced Homo- and Heterodimerization of All gp130-Type Receptor Complexes Leads to Constitutive Ligand-independent Signaling and Cytokine-independent Growth." Molecular Biology of the Cell 21, no. 15 (August 2010): 2797–807. http://dx.doi.org/10.1091/mbc.e10-03-0240.

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Naturally ligand independent constitutively active gp130 variants were described to be responsible for inflammatory hepatocellular adenomas. Recently, we genetically engineered a ligand-independent constitutively active gp130 variant based on homodimerization of Jun leucine zippers. Because also heterodimeric complexes within the gp130 family may have tumorigenic potential, we seek to generate ligand-independent constitutively active heterodimers for all known gp130-receptor complexes based on IL-15/IL-15Rα-sushi fusion proteins. Ligand-independent heterodimerization of gp130 with WSX-1, LIFR,

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Czekay, R. P., R. A. Orlando, L. Woodward, M. Lundstrom, and M. G. Farquhar. "Endocytic trafficking of megalin/RAP complexes: dissociation of the complexes in late endosomes." Molecular Biology of the Cell 8, no. 3 (March 1997): 517–32. http://dx.doi.org/10.1091/mbc.8.3.517.

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Megalin (gp330) is a member of the low-density lipoprotein receptor gene family. Like other members of the family, it is an endocytic receptor that binds a number of specific ligands. Megalin also binds the receptor-associated protein (RAP) that serves as an exocytic traffic chaperone and inhibits ligand binding to the receptor. To investigate the fate of megalin/RAP complexes, we bound RAP glutathione-S-transferase fusion protein (RAP-GST) to megalin at the surface of L2 yolk sac carcinoma cells and followed the trafficking of the complexes by immunofluorescence and immunogold labeling and by

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Niu, Linghao, David W. Golde, Juan Carlos Vera, and Mark L. Heaney. "Kinetic Resolution of Two Mechanisms for High-Affinity Granulocyte-Macrophage Colony-Stimulating Factor Binding to Its Receptor." Blood 94, no. 11 (December 1, 1999): 3748–53. http://dx.doi.org/10.1182/blood.v94.11.3748.423k16_3748_3753.

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Granulocyte-macrophage colony-stimulating factor (GM-CSF) is an important hematopoietic cytokine that exerts its effects by interaction with the GM-CSF receptor (GMR) on the surface of responsive cells. The GM-CSF receptor consists of two subunits: GMR, which binds GM-CSF with low affinity, and GMRβ, which lacks intrinsic ligand-binding capability but complexes with GMR to form a high-affinity receptor (GMR/β). We conducted dynamic kinetic analyses of GM-CSF receptors to define the role of GMRβ in the interaction of ligand and receptor. Our data show that GMR/β exhibits a higher kon than G

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Clark, Kevin P., and Ajay. "Flexible ligand docking without parameter adjustment across four ligand-receptor complexes." Journal of Computational Chemistry 16, no. 10 (October 1995): 1210–26. http://dx.doi.org/10.1002/jcc.540161004.

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Meijsing, Sebastiaan H., Cem Elbi, Hans F. Luecke, Gordon L. Hager, and Keith R. Yamamoto. "The Ligand Binding Domain Controls Glucocorticoid Receptor Dynamics Independent of Ligand Release." Molecular and Cellular Biology 27, no. 7 (January 29, 2007): 2442–51. http://dx.doi.org/10.1128/mcb.01570-06.

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ABSTRACT Ligand binding to the glucocorticoid receptor (GR) results in receptor binding to glucocorticoid response elements (GREs) and the formation of transcriptional regulatory complexes. Equally important, these complexes are continuously disassembled, with active processes driving GR off GREs. We found that cochaperone p23-dependent disruption of GR-driven transcription depended on the ligand binding domain (LBD). Next, we examined the importance of the LBD and of ligand dissociation in GR-GRE dissociation in living cells. We showed in fluorescence recovery after photobleaching studies tha

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Niu, Linghao, David W. Golde, Juan Carlos Vera, and Mark L. Heaney. "Kinetic Resolution of Two Mechanisms for High-Affinity Granulocyte-Macrophage Colony-Stimulating Factor Binding to Its Receptor." Blood 94, no. 11 (December 1, 1999): 3748–53. http://dx.doi.org/10.1182/blood.v94.11.3748.

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Abstract Granulocyte-macrophage colony-stimulating factor (GM-CSF) is an important hematopoietic cytokine that exerts its effects by interaction with the GM-CSF receptor (GMR) on the surface of responsive cells. The GM-CSF receptor consists of two subunits: GMR, which binds GM-CSF with low affinity, and GMRβ, which lacks intrinsic ligand-binding capability but complexes with GMR to form a high-affinity receptor (GMR/β). We conducted dynamic kinetic analyses of GM-CSF receptors to define the role of GMRβ in the interaction of ligand and receptor. Our data show that GMR/β exhibits a higher k

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Danilowicz, Claudia, Derek Greenfield, and Mara Prentiss. "Dissociation of Ligand−Receptor Complexes Using Magnetic Tweezers." Analytical Chemistry 77, no. 10 (May 2005): 3023–28. http://dx.doi.org/10.1021/ac050057+.

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Thèses sur le sujet "Receptor-ligand complexes"

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Patel, Amesh Babubhai. "Biophysical and computational investigations into receptor-ligand complexes." Thesis, University of Nottingham, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.435998.

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Wang, Xiang. "Computational studies of melanocortin receptor system and channel function in glutamine-dependent amidotransferases." [Gainesville, Fla.] : University of Florida, 2003. http://purl.fcla.edu/fcla/etd/UFE0001072.

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Bishop, Benjamin F. "Structural and functional characterisation of hedgehog ligand-receptor complexes." Thesis, University of Oxford, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.642625.

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Members of the Hedgehog (HH) family of morphogenic signalling molecules are key mediators of many fundamental processes in embryonic development. A relatively small change in HH concentration results in the specification of distinct cell types. Such fine-tuning necessitates a range of regulatory cell-surface proteins to control the concentration of HH to which responding cells are exposed. This thesis focuses on the structural and functional characterisation of three human extracellular modulators of the HH pathway, namely the hedgehog-interacting protein HHIP, the glypican GPC3 and the Growth

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Coonan, Jason R. "Regulation of neural connectivity by the EphA4 receptor tyrosine kinase /." Connect to thesis, 2001. http://eprints.unimelb.edu.au/archive/00000727.

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Nahas, Roger I. "Synthesis and structure-activity relationship of a series of sigma receptor ligands." Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/4840.

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Thesis (Ph. D.)--University of Missouri-Columbia, 2007.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on February 26, 2008) Vita. Includes bibliographical references.

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Read, Stuart Hamilton. "Production and function of a soluble c-Kit molecule." Title page, abstract and contents only, 2001. http://web4.library.adelaide.edu.au/theses/09PH/09phr2845.pdf.

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"Research conducted at the Department of Haematology, Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science."--T.p. Includes bibliographical references (leaves 170-214). Elevated levels of receptor tyrosine kinases have been implicated in carcinogenesis. It is possible that high expression of c-Kit by the leukaemic cell provides them with a growth advantage over their normal counterparts in the bone marrow microenvironment. Thus, a means of inhibiting the interaction of c-Kit on these cells with ligand Steel Factor may remove proliferation and survival signals. Main ai

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Lengqvist, Johan. "Native protein mass spectrometry of nuclear receptor-ligand and enzyme-substrate complexes /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-116-4/.

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Smith, Mark Edward. "Molecular wires : syntheses, electrochemistry and properties of metal complexes containing carbon chains /." Title page, contents and abstract only, 2002. http://web4.library.adelaide.edu.au/theses/09PH/09phs654.pdf.

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Thesis (Ph.D.)--University of Adelaide, Dept. of Chemistry, 2002.<br>"September 2002" Includes as appendix: a list of publications by the author arising from this work; and, copies of some published journal articles. Includes bibliographical references.

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Yamamoto, Izumi. "Structure-function studies of GABA-C receptor ligands." Thesis, The University of Sydney, 2012. https://hdl.handle.net/2123/28927.

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Throughout the central nervous system (CNS), the Cys-loop superfamily of ligand-gated ion channels {LGICs), including nicotinic acetylcholine, serotonin type-3A, strychnine-sensitive glycine and y-aminobutyric acid A/C receptors, play important roles in synaptic transmission by converting chemical signals into electric signals. Designing potent and subtype-selective ligands with therapeutic value requires knowledge about how ligands interact with their binding sites. y-Aminobutyric acid (GABA) is the predominant inhibitory neurotransmitter in the mammalian CNS and its binding modes at GABA r

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Nervall, Martin. "Binding Free Energy Calculations on Ligand-Receptor Complexes Applied to Malarial Protease Inhibitors." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8338.

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Livres sur le sujet "Receptor-ligand complexes"

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S, Zhorov B., ed. Ligand-ret͡s︡eptornye vzaimodeĭstvii͡a︡ v molekuli͡a︡rnoĭ fiziologii. Sankt-Peterburg: "Nauka", 1994.

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Health Effects Research Laboratory (Research Triangle Park, N.C.), ed. Characterization of the Ah receptor: Project summary. Research Triangle Park, NC: U.S. Environmental Protection Agency, Health Effects Research Laboratory, 1989.

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Safe, Stephen H. Characterization of the Ah receptor: Project summary. Research Triangle Park, NC: U.S. Environmental Protection Agency, Health Effects Research Laboratory, 1989.

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C, Hulme E., ed. Receptor-ligand interactions: A practical approach. Oxford [England]: IRL Press at Oxford University Press, 1992.

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A, Burgen, and Barnard Eric A. 1927-, eds. Receptor subunits and complexes. Cambridge [England]: Cambridge University Press, 1992.

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Browne, M. J. Recombinant cells surface receptors: Focal point for therapeutic intervention. Austin, Tex: R.G. Landes Co., 1996.

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Hestermann, Eli V. Mechanisms of action for aryl hydrocarbon receptor ligands in the PLHC-1 cell line. Cambridge, Mass: Massachusetts Institute of Technology, 2000.

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1961-, Keen Mary, ed. Receptor binding techniques. Totowa, N.J: Humana Press, 1999.

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P, Davenport Anthony, ed. Receptor binding techniques. 2nd ed. Totowa, N.J: Humana Press, 2005.

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1957-, Russell David W., and Mangelsdorf David J. 1958-, eds. Nuclear receptors. Amsterdam: Elsevier Academic Press, 2002.

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Chapitres de livres sur le sujet "Receptor-ligand complexes"

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Vermeer, B. J., A. M. Mommaas-Kienhuis, M. C. Wijsman, J. J. Emeis, and M. Ponec. "A Model for Morphological Studies on Ligand-Receptor Complexes." In Skin Models, 315–26. Berlin, Heidelberg: Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-70387-4_35.

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Pogozheva, Irina D., Magdalena J. Przydzial, and Henry I. Mosberg. "Homology Modeling of Opioid Receptor-Ligand Complexes Using Experimental Constraints." In Drug Addiction, 559–84. New York, NY: Springer New York, 2008. http://dx.doi.org/10.1007/978-0-387-76678-2_33.

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Lozoya, Estrella, Maria Isabel Loza, and Ferran Sanz. "Modelling of the 5-HT2A Receptor and Its Ligand Complexes." In Molecular Modeling and Prediction of Bioactivity, 355–56. Boston, MA: Springer US, 2000. http://dx.doi.org/10.1007/978-1-4615-4141-7_74.

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Limbird, Lee E. "Biochemical Correlates of the Topographical Fate of Ligand-Receptor Complexes." In Cell Surface Receptors: A Short Course on Theory and Methods, 159–94. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4757-1882-9_6.

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Perales, Jose C., Thomas Ferkol, Maria Molas, and Richard W. Hanson. "An evaluation of receptor-mediated gene transfer using synthetic DNA-ligand complexes." In EJB Reviews 1994, 209–20. Berlin, Heidelberg: Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-642-79502-2_16.

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Krishna, N. Rama, and V. Jayalakshmi. "Quantitative Analysis of STD-NMR Spectra of Reversibly Forming Ligand–Receptor Complexes." In Topics in Current Chemistry, 15–54. Berlin, Heidelberg: Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/128_2007_144.

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Wang, Andrew H. J., Yen-Chywan Liaw, Howard Robinson, and Yi-Gui Gao. "Mutual Conformational Adaptation of Both Ligand and Receptor in Antitumor Drug-DNA Complexes." In The Jerusalem Symposia on Quantum Chemistry and Biochemistry, 1–21. Dordrecht: Springer Netherlands, 1990. http://dx.doi.org/10.1007/978-94-011-3728-7_1.

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Khashan, Raed S. "Generating “Fragment-Based Virtual Library” Using Pocket Similarity Search of Ligand–Receptor Complexes." In Methods in Molecular Biology, 23–29. New York, NY: Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-2486-8_3.

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Limbird, Lee E. "The Topographical Fate of Ligand-Receptor Complexes as Reflected by the Properties of Ligand Binding to Intact Cells." In Cell Surface Receptors: A Short Course on Theory and Methods, 201–32. Boston, MA: Springer US, 1996. http://dx.doi.org/10.1007/978-1-4613-1255-0_6.

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Rejto, Paul A., Gennady M. Verkhivker, Daniel K. Gehlhaar, and Stephan T. Freer. "New trends in computational structure prediction of ligand-protein complexes for receptor-based drug design." In Computer Simulation of Biomolecular Systems, 451–65. Dordrecht: Springer Netherlands, 1997. http://dx.doi.org/10.1007/978-94-017-1120-3_17.

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Actes de conférences sur le sujet "Receptor-ligand complexes"

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Ates, Abdullah, Baris Baykant Alagoz, Aleksei Tepljakov, Eduard Petlenkov, Celaledddin Yeroglu, Aleksei Kuznetsov, and Innokenti Sobolev. "Fractional Order Model Identification of Receptor-Ligand Complexes Formation by Equivalent Electrical Circuit Modeling." In 2019 International Artificial Intelligence and Data Processing Symposium (IDAP). IEEE, 2019. http://dx.doi.org/10.1109/idap.2019.8875913.

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Wallrabe, Horst, Ammasi Periasamy, Almut Burchard, and Margarida Barroso. "Comparing different FRET techniques to measure clustering of receptor-ligand complexes in endocytic membranes." In Biomedical Optics 2003, edited by Ammasi Periasamy and Peter T. C. So. SPIE, 2003. http://dx.doi.org/10.1117/12.485606.

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Fanelli, F., M. C. Menziani, M. Cocchi, A. Carotti, and P. G. De Benedetti. "Theoretical approaches to quantitative structure-activity relationship (QSAR) analysis of M1-muscarinic receptor-ligand complexes." In The first European conference on computational chemistry (E.C.C.C.1). AIP, 1995. http://dx.doi.org/10.1063/1.47825.

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Rudkouskaya, Alena, Nattawut Sinsuebphon, Xavier Intes, Joseph E. Mazurkiewicz, and Margarida Barroso. "Fluorescence lifetime FRET imaging of receptor-ligand complexes in tumor cells in vitro and in vivo." In SPIE BiOS, edited by Ammasi Periasamy, Peter T. C. So, Karsten König, and Xiaoliang S. Xie. SPIE, 2017. http://dx.doi.org/10.1117/12.2258231.

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Petrović, Đorđe, Maja Đukić, Edina Avdović, Danijela Stojković, Verica Jevtić, Sandra Jovičić Milić, and Marina Vesović. "DNA binding and molecular docking of four palladium(II) complexes with O,O’-dialkyl esters of (S,S)-propylenediamine-N,N’-di-2-(2-benzyl) acetic acid." In 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.539p.

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The antitumor activity of platinum-based complexes still captures the attention of scientists and new potential drugs are being synthesized and investigated. Although complexes of palladium(II) ion show less cytotoxicity compared to platinum(II) complexes due to the high reactivity of the palladium center, research in this field has continued and many authors have found that auxiliary chelating ligands can improve complex stability and their cytotoxicity. As a consequence of rapid ligand exchange, the probability of palladium(II) complexes reaching the biological target in organisms seems to b

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Chesla, Scott E., and Cheng Zhu. "Validation and Accuracy Assessment of the Micropipet Piconewton Force Transducer." In ASME 1996 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 1996. http://dx.doi.org/10.1115/imece1996-1112.

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Abstract In processes that involve interactions of the cell with its environment, adhesion is often the initiating event for a particular cellular function. Adhesion assays are thus among the first to be used to characterize the essential molecular complexes involved. Recently, increasing attention has been focused on single molecular binding between a particular cellular receptor class and its ligand. Elucidation of the forces involved in single bonds can lead to better understanding of how cells deal with their environment via controlling the specificity and strength of their adhesions.

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Wallrabe, Horst, Masilamani Elangovan, Almut Burchard, Ammasi Periasamy, and Margarida Barroso. "FRET microscopy reveals clustered distribution of co-internalized receptor-ligand complexes in the apical recycling endosome of polarized epithelial MDCK cells." In International Symposium on Biomedical Optics, edited by Ammasi Periasamy and Peter T. C. So. SPIE, 2002. http://dx.doi.org/10.1117/12.470677.

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Wallrabe, Horst K., and Margarida Barroso. "FRET reveals the organization of different receptor-ligand complexes (polymeric IgA-R and Transferrin-R) in endocytic membranes of polarized MDCK cells." In Biomedical Optics 2004, edited by Ammasi Periasamy and Peter T. C. So. SPIE, 2004. http://dx.doi.org/10.1117/12.539755.

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Wallrabe, Horst, Masilamani Elangovan, Almut Burchard, and Margarida Barroso. "Energy transfer efficiency based on one-and two-photon FRET microscopy differentiates between clustered and random distribution of membrane-bound receptor-ligand complexes." In International Symposium on Biomedical Optics, edited by Ammasi Periasamy and Peter T. C. So. SPIE, 2002. http://dx.doi.org/10.1117/12.470703.

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Brewer, Bryson M., Yandong Gao, Rebecca M. Sappington, and Deyu Li. "Microfluidic Molecular Trap: Probing Extracellular Signaling by Selectively Blocking Exchange of Specific Molecules in Cell-Cell Interactions." In ASME 2013 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/imece2013-64489.

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Communication among cell populations is achieved via a wide variety of soluble, extracellular signaling molecules [1]. In order to investigate the role of specific molecules in a cellular process, researchers often utilize in vitro cell culture techniques in which the molecule under question has been removed from the signaling pathway. Traditionally, this has been accomplished by eliminating the gene in the cell that is responsible for coding the targeted ligand/receptor by using modern DNA technology such as gene knockout; however, this process is expensive, time-consuming, and labor intensiv

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Rapports d'organisations sur le sujet "Receptor-ligand complexes"

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Rafaeli, Ada, and Russell Jurenka. Molecular Characterization of PBAN G-protein Coupled Receptors in Moth Pest Species: Design of Antagonists. United States Department of Agriculture, December 2012. http://dx.doi.org/10.32747/2012.7593390.bard.

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The proposed research was directed at determining the activation/binding domains and gene regulation of the PBAN-R’s thereby providing information for the design and screening of potential PBAN-R-blockers and to indicate possible ways of preventing the process from proceeding to its completion. Our specific aims included: (1) The identification of the PBAN-R binding domain by a combination of: (a) in silico modeling studies for identifying specific amino-acid side chains that are likely to be involved in binding PBAN with the receptor and; (b) bioassays to verify the modeling studies using mut

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Rafaeli, Ada, Russell Jurenka, and Chris Sander. Molecular characterisation of PBAN-receptors: a basis for the development and screening of antagonists against Pheromone biosynthesis in moth pest species. United States Department of Agriculture, January 2008. http://dx.doi.org/10.32747/2008.7695862.bard.

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The original objectives of the approved proposal included: (a) The determination of species- and tissue-specificity of the PBAN-R; (b) the elucidation of the role of juvenile hormone in gene regulation of the PBAN-R; (c) the identificationof the ligand binding domains in the PBAN-R and (d) the development of efficient screening assays in order to screen potential antagonists that will block the PBAN-R. Background to the topic: Moths constitute one of the major groups of pest insects in agriculture and their reproductive behavior is dependent on chemical communication. Sex-pheromone blends are

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Eyal, Yoram, and Sheila McCormick. Molecular Mechanisms of Pollen-Pistil Interactions in Interspecific Crossing Barriers in the Tomato Family. United States Department of Agriculture, May 2000. http://dx.doi.org/10.32747/2000.7573076.bard.

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During the evolutionary process of speciation in plants, naturally occurring barriers to reproduction have developed that affect the transfer of genes within and between related species. These barriers can occur at several different levels beginning with pollination-barriers and ending with hybrid-breakdown. The interaction between pollen and pistils presents one of the major barriers to intra- and inter-specific crosses and is the focus of this research project. Our long-term goal in this research proposal was defined to resolve questions on recognition and communication during pollen-pistil

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Chen, Yona, Jeffrey Buyer, and Yitzhak Hadar. Microbial Activity in the Rhizosphere in Relation to the Iron Nutrition of Plants. United States Department of Agriculture, October 1993. http://dx.doi.org/10.32747/1993.7613020.bard.

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Iron is the fourth most abundant element in the soil, but since it forms insoluble hydroxides at neutral and basic pH, it often falls short of meeting the basic requirements of plants and microorganisms. Most aerobic and facultative aerobic microorganisms possess a high-affinity Fe transport system in which siderophores are excreted and the consequent Fe complex is taken up via a cognate specific receptor and a transport pathway. The role of the siderophore in Fe uptake by plants and microorganisms was the focus of this study. In this research Rhizopus arrhizus was found to produce a novel sid

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Epel, Bernard, and Roger Beachy. Mechanisms of intra- and intercellular targeting and movement of tobacco mosaic virus. United States Department of Agriculture, November 2005. http://dx.doi.org/10.32747/2005.7695874.bard.

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To cause disease, plant viruses must replicate and spread locally and systemically within the host. Cell-to-cell virus spread is mediated by virus-encoded movement proteins (MPs), which modify the structure and function of plasmodesmata (Pd), trans-wall co-axial membranous tunnels that interconnect the cytoplasm of neighboring cells. Tobacco mosaic virus (TMV) employ a single MP for cell- cell spread and for which CP is not required. The PIs, Beachy (USA) and Epel (Israel) and co-workers, developed new tools and approaches for study of the mechanism of spread of TMV that lead to a partial iden

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