Articles de revues : « Ruan jian »

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Zhu, Di, Chenglin Jia, Tongkai Cai, Jiacheng Li, Xia Feng, Nan Chen, Cheng Zhao, Yuzhen Wang, Yongbing Cao et Yemin Cao. « Ruan Jian Qing Mai Recipe Inhibits the Inflammatory Response in Acute Lower Limb Ischemic Mice through the JAK2/STAT3 Pathway ». Evidence-Based Complementary and Alternative Medicine 2022 (18 août 2022) : 1–10. http://dx.doi.org/10.1155/2022/2481022.

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Ruan jian qing mai recipe (RJQM) is an empirical prescription for treating arteriosclerosis obliterans (ASO). However, the mechanism of RJQM recipe-mediated ASO attenuation has not yet been elucidated. Therefore, this study aimed to explore the mechanism by which the RJQM recipe relieves ASO in a mouse model of lower limb ischemia, which was established by ligating and breaking the femoral artery of the left lower limb. The surgical groups were divided into the ischemic group, beraprost sodium group, low-dose RJQM group, medium-dose RJQM group, and high-dose RJQM group. Normal mice were set as the control group. The blood flow of the lower limb was examined on days 7 and 14. At the end of animal procedures, blood samples were collected, and the rectus femoris of the left lower limb were harvested. Results revealed that mice in the ischemic group demonstrated low blood flow. Additionally, hematoxylin and eosin, and Masson staining results showed that inflammation of the rectus femoris was obvious in the ischemia group, and the level of fibrosis was increased. Blood flow was recovered in all treatment groups compared to the ischemic group, and the inflammatory infiltration and fibrosis of the rectus femoris were relieved after RJQM treatment. The serum levels of interleukin (IL)-17A and IL-21 were decreased, and the expression of JAK2/STAT3 proteins was inhibited in all RJQM treatment groups compared to the ischemia group. Furthermore, the improvement of IL-17A, IL-21, and rectus femoris fibrosis was more obvious with increasing treatment time. In conclusion, RJQM can effectively alleviate ASO and promote the recovery of lower limb blood flow by regulating the JAK2/STAT3 signaling pathway to reduce the inflammatory response.

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Schultz, Corey Kai Nelson. « Ruin in the films of Jia Zhangke ». Visual Communication 15, n^o 4 (29 septembre 2016) : 439–60. http://dx.doi.org/10.1177/1470357216633921.

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Nurhaiza, Nurhaiza. « KAJIAN ORGANISASI RUANG PADA BANGUNAN RUMAH TJONG A FIE BERDASARKAN KAIDAH ARSITEKTUR CINA ». Jurnal Arsitekno 5, n^o 5 (21 février 2019) : 42. http://dx.doi.org/10.29103/arj.v5i5.1233.

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Rumah Tjong A Fie adalah salah satu bangunan yang dilindungi sebagai artefak warisan sejarah Kota Medan yang memperlihatkan nilai-nilai historis, budaya, dan pengetahuan. Tujuan dari penelitian ini adalah menemukan organisasi ruang pada bangunan Rumah Tjong A Fie berdasarkan filosofi arsitektur tradisional Cina. Hasil kajian ini akan memberikan gambaran potensi dan keunikan yang dimiliki oleh Rumah Tjong A Fie sebagai salah satu arsitektur hunian peninggalan etnis Tionghoa pada zamannya. Metode penelitian arsitektur yang digunakan adalah metode penelitian kualitatif interpretive-historical, yaitu meneliti suatu fenomena fisik/sosial yang berada di antara konteks yang komplek, melalui penjelasan dalam bentuk naratif dan menyeluruh.Penelitian akan melalui beberapa tahapan, yaitu; 1) Pengumpulan dan klasifikasi data primer dan sekunder; 2) Evaluasi data melalui analisis danpenilaian berupa interpretasi terhadap data; dan 3) Kesimpulan berupa penjelasan dalam bentuk narasi. Hasilpenelitian menunjukkan bahwa Rumah Tjong A Fie menerapkan konsep arsitektur tradisional Cina pada organisasi ruangnya berdasarkan filosofi tradisional Cina, yaitu: 1) Dao; 2) Kongfusianisme; dan 3) Feng-shui. Konsep arsitektur tradisional Cina direfleksikan pada elemen-elemen arsitektur 1) dinding pembatas; 2) Jian; 3) Aksis; 4) Orientasi ruang; dan 5) Courtyard.

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Xudong, Zhang. « Poética da desaparição : os filmes de Jia Zhangke ». Novos Estudos - CEBRAP, n^o 89 (mars 2011) : 71–87. http://dx.doi.org/10.1590/s0101-33002011000100005.

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Os filmes de Jia Zhangke oferecem retratos das transformações sociais e econômicas ocorridas na China, do ponto de vista das ruas e à margem dos grandes centros. O artigo explora os temas do desaparecimento, demolição e deslocamento na obra do diretor chinês.

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Li, Jin, Zhanglin Li, Shiru Lan et Yong Wu. « The Subexponential Distribution wthin Renewal Model ». Advances in Economics and Management Research 1, n^o 1 (18 mai 2022) : 9. http://dx.doi.org/10.56028/aemr.1.1.9.

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Here, we investigate asymptotic equivalent formulas for finite-time ruin probabilities in a renewal risk model with a subexponential distribution in this research, in the cases of the negatively dependent and upper tail independent, respectively. First, we extend the related research results of Tao Jiang, and Chengguo Weng et al. to the subexponential case, respectively. Thereafter two precise asymptotic equivalent relations are established, one is the finite-time probability when the random variables of the claims are influenced by the common subexponential distribution in a negative way, and another the finite-time ruin probability when the claimsizes are upper tail independent with the common subexponential distribution.

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Nurwadjedi, Nurwadjedi, Lien Rosalina et Yusuf Wibisono. « MEMBANGUN SATU PETA UNTUK PENATAAN RUANG ». Seminar Nasional Geomatika 3 (15 février 2019) : 157. http://dx.doi.org/10.24895/sng.2018.3-0.946.

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Diterbitkannya Percepatan Pelaksanaan Kebijakan Satu Peta dilatarbelakangi oleh banyaknya konflik pemanfaatan ruang atau tumpang-tindih penggunaan lahan antar sektor yang menghambat investasi pembangunan infrastruktur dan kawasan di daerah. Terjadinya konflik pemanfaatan ruang tersebut disebabkan oleh penyelenggaraan penyelenggaraan Informasi Geospasial Tematik (IGT) yang tidak mengacu pada Informasi Geospasial Dasar (IGD). Selain itu, konflik pemanfaatan ruang tersebut juga disebabkan oleh masih banyaknya peta Rencana Tata Ruang Wilayah (RTRW) Kabupaten/Kota yang tidak akurat, sebagai akibat belum tersedianya IGT pada skala yang memadai untuk penyusunan peta RTRW Kabupaten/Kota. Oleh karena itu, percepatan Kebijakan Satu Peta sangat diperlukan untuk menyelesaikan permasalahan konflik pemenfaatan ruang tersebut. Tujuan penelitian ini adalah untuk menyusun Satu Peta penataan ruang atau Satu Peta dataset IGT terintegrasi skala 1: 50.000 atau 1: 25.000 yang diperlukan untuk penyusunan peta RTRW Kabupaten/Kota. Dataset IGT yang disusun menjadi Satu Peta merupakan kumpulan layer IGT yang diproduksi oleh instansi terkait yang berperan sebagai walidata. Metode untuk mewujudkan Satu Peta penataan ruang tersebut menggunakan kriteria Kebijakan Satu Peta, yaitu satu referensi, satu standar, satu basisdata, dan satu geoportal. Penelitian ini menghasilkan Satu Peta dataset IGT terintegrasi skala 1: 50.000 atau 1:25.000 yang mengacu pada IGD dengan format geodatabase. Dari hasil penelitian ini dapat disimpulkan bahwa peta-peta tematik (dataset IGT) yang diproduksi oleh instansi terkait dapat diintegrasikan menjadi Satu Peta, dengan mengacu pada IGD (Peta Rupabumi) dan standar spesifikasi basisdata. Selain untuk penyusunan peta RTRW Kabupaten/kota, Satu Peta dataset IGT terintegrasi yang dihasilkan dapat diberbagikan melalui Jaringan Informasi Geospasial Nasional (JIGN) untuk penyelesaian konflik pemanfaatan ruang.

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Straughn, Ian. « Spirits of Heritage, Specters of Ruins : Partnering with the Jinn in the Preservation of the Past ». Review of Middle East Studies 51, n^o 2 (août 2017) : 196–202. http://dx.doi.org/10.1017/rms.2017.98.

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In her recent study of the heritage project that is contemporary New Orleans, anthropologist Shanon Dawdy has suggested that “[s]ociety presents itself simultaneously as a ruin and as a kind of playland” (2016, 147). This notion that the ruin is both a product of, and a basis for, heritage practice serves as a useful intervention into long-standing treatments of ruins as exotic, romantic, and awaiting the discovery, glorification, and preservation of those that might give them meaning. In the present essay, I further challenge heritage approaches to ruins through an examination of the ways in which they have been associated, in various Muslim cultural contexts, with a set of distinctly sentient, yet non-human actors, the jinn. This pairing between place and spirits has shaped long-standing affective responses and practical engagements between local (human) inhabitants and their archaeologically rich landscapes across the Middle East and North Africa. This essay examines how those engagements often push against contemporary discourses highlighting the sublime aspects of ruins and the quasi-sacred nature of heritage. To that end, the following guiding questions structure my contribution: Can contemporary heritage discourses accommodate practices in which humans share control and ownership of the material past with spectral others? How might we reframe the mandate to preserve such ruins in light of alternative perspectives that mark these sites as sinister, and/or meaningful, precisely because of their ruination? Can universalizing heritage discourses accommodate practices that derive value from the material past without also subscribing to explicit preservationist goals? Such questions offer an opportunity to consider the inclusion of the Unseen, and perhaps others, whose perspectives have gone unrecognized, within professional heritage management and its hermeneutics of the past.

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Huda, Novia Nur, Sri Suryoko et Handojo Djoko Waloejo. « Pengaruh Kualitas Pelayanan dan Fasilitas Wisata terhadap Keputusan Berkunjung Kembali dengan Kepuasan Pengunjung sebagai Variabel Intervening (Studi pada Pengunjung Hortimart Agro Center Bawen) ». Jurnal Ilmu Administrasi Bisnis 11, n^o 2 (18 octobre 2022) : 198–206. http://dx.doi.org/10.14710/jiab.2022.34405.

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Hortimart Agro Center Bawen merupakan salah satu destinasi agrowisata yang didirikan tahun 1970 dan lokasinya berada di Jalan Gatot Subroto No. 55, Bawen, Kabupaten Semarang. Jumlah pengunjung Agrowisata Hortimart Agro Center secara absolut terus mengalami kenaikan setiap tahunnya yang tercatat dalam empat tahun terakhir, namun selama dua tahun terakhir realisasi pengunjung yang berkunjung belum mencapai target yang ditentukan oleh perusahaan dan selama empat tahun terakhir keluhan selama kunjungan juga mengalami kenaikan. Tujuan penelitian ini adalah untuk mengetahui pengaruh kualitas pelayanan dan fasilitas wisata terhadap keputusan berkunjung kembali melalui kepuasan pengunjung. Tipe penelitian ini adalah explanatory research dengan teknik pengumpulan data melalui penyebaran kuesioner dan wawancara. Sampel dari penelitian ini adalah 100 pengunjung Hortimart Agro Center Bawen yang pernah melakukan kunjungan lebih dari 1 kali. Analisis data menggunakan teknik analisis jalur dibantu dengan software Statistical Package for Social Science (SPSS) versi 25.0 for windows dimana sebelumnya digunakan uji validitas, reliabilitas, koefisien korelasi, koefisien determinasi, analisis regresi sederhana dan berganda, uji signifikansi (uji t dan uji f), uji sobel terlebih dahulu. Hasil penelitian menunjukkan bahwa seluruh variabel independen memiliki pengaruh signifikan terhadap variabel dependen, sedangkan variabel kepuasan pengunjung berperan sebagai variabel mediasi parsial penuh yang menunjukkan ada pengaruh tidak langsung variabel kualitas pelayanan dan fasilitas wisata terhadap keputusan berkunjung kembali. Saran yang diajukan meliputi : menambahkan kanopi pada lahan parkir motor, mempertimbangkan penambahan mobil keliling atau bisa diganti dengan sepeda, menambahkan bangku dan gazebo di titik destinasi wisata yang ramai seperti di daerah waduk, penggantian dengan wisata lain yang masih bisa dinikmati di waduk tersebut tanpa menutup akses ke waduk saat musim kemarau, menyediakan beberapa pos pengamanan yang dapat jelas dilihat dan mudah dijangkau oleh pengunjung, mobil keliling diberi ruang khusus untuk penyandang disabilitas, dan penambahan jumlah bangku tunggu di sekitar restoran, Kotak saran perlu ditambah pada lokasi yang bisa terlihat jelas oleh pengunjung.

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Arini, Maghfira Dwinintya, et Sudharto Prawoto Hadi. « Pengaruh Motivasi, Budaya Organisasi, Dan Lingkungan Kerja Terhadap Kinerja Karyawan Pada Pt. Dan Liris Sukohardjo (Studi Pada Karyawan Divisi Weaving) ». Jurnal Ilmu Administrasi Bisnis 10, n^o 1 (6 avril 2021) : 736–41. http://dx.doi.org/10.14710/jiab.2021.29770.

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Abstract: The company's success can be reached by achieving the company's target. Based on data obtained from employee performance at PT. Dan Liris Sukoharjo showed a decline in 2018-2019. There are indications of a decrease in employee performance caused by motivation, organisational culture, and work environment. This type of research is explanatory research, out of 359 employees taken as many as 78 respondents into a sample who are employees of PT. Dan Liris Sukohardjo weaving division. In this research, Simple Random Sampling Technique is used to do sampling. The techniques used in collecting data are questionnaires and literature studies. This study used of IBM SPSS program version 25.0. Based on the test results simultaneously, there is a significant and positive influence between the variables of motivation, organizational culture, and work environment on employee performance. Suggestions that can be made by the company PT. Dan Liris Sukohardjo increasing motivation, giving appreciation to employees such as awards, and giving promotions for employees who have worked well. The company needs to consider the employees to implement the applicable system, to work in accordance with the responsibilities given and also to give a proper understanding of the company culture. As for supporting a good environment, it is necessary to provide insurances for employees working with machines, and to discipline employees more to work with the tools provided. Also, the company provides a special room for machines so that other employees feel more comfortable while working. Keywords : Motivation; Organizational Culture; Work Environment; Employee Performance Abstrak: Keberhasilan perusahaan dapat dicapai dengan tercapainya target perusahaan. Berdasarkan data yang diperoleh dari kinerja karyawan pada PT. Dan Liris Sukoharjo menunjukkan penurunan pada tahun 2018-2019. Terdapat indikasi penurunan pada kinerja karyawan yang disebabkan oleh motivasi, budaya organisasi dan lingkungan kerja. Tipe penelitian ini adalah explanatory research, dari 359 karyawan diambil sebanyak 78 responden menjadi sampel yang merupakan karyawan PT. Dan Liris Sukohardjo divisi weaving. Pengambilan sampel menggunakan Teknik Simple Random Sampling. Teknik pengumpulan data menggunakan kuesioner dan studi pustaka. Penelitian ini menggunakan program IBM SPSS versi 25.0. Berdasarkan hasil uji secara simultan terdapat pengaruh signifikan dan positif antara variabel motivasi, budaya organisasi, dan lingkungan kerja terhadap kinerja karyawan. Saran yang dapat dilakukan oleh perusahaan PT. Dan liris Sukohardjo untuk meningkatkan motivasi seperti memberikan apresiasi pada karyawan seperti penghargaan dan memberikan kenaikkan jabatan bagi karyawan yang sudah bekerja dengan baik. Perusahaan perlu memperhatikan karyawan agar dapat melaksanakan sistem yang berlaku, bekerja sesuai dengan tanggung jawab yang diberikan dan memberikan pemahaman mengenai budaya yang berlaku pada perusahaan tersebut. Adapun untuk mendukung lingkungan yang baik perlu diberikan perlindungan kepada karyawan yang bekerja dengan mesin dan lebih mendisiplinkan karyawan agar bekerja dengan alat yang disediakan serta perusahaan menyediakan ruangan khusus untuk mesin agar karyawan lain lebih merasa nyaman saaat bekerja. Kinerja karyawan PT. Dan Liris Sukohardjo. hal tersebut dibuktikan dengan uii regresi berganda sebesar 0,336, 0,137, dan 0,161. Saran yang dapat dilakukan oleh perusahaan PT Dan liris Sukohardjo perlu memberikan penghargaan kepada karyawan dan jenjang karir, memastikan karyawan juga bekerja sesuai dengan aturan yang berlaku dan memberikan ruang yang nyaman bebas dari suara bising dan pencahayaan yang memadai. Kata Kunci : Motivasi; Budaya Organisasi; Lingkungan Kerja; Kinerja Karyawan

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Prima Minerva, Murni Astuti et Tyas Asih. « PENINGKATAN KUALITAS PELAYANAN SALON KECANTIKAN BERBASIS KESEHATAN PADA KELOMPOK PENGUSAHA SALON KECANTIKAN DI KOTA PARIAMAN ». Journal of Community Service 1, n^o 1 (17 décembre 2019) : 089–95. http://dx.doi.org/10.56670/jcs.v1i1.13.

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Perkembangan salon kecantikan saat ini bergeser arah ke pusat kecantikan seperti skin care atau beauty care melibatkankan sektor kesehatan dalam melakukan pelayanan perawatan. Beberapa salon kecantikan di Pariaman masih yang banyak yang belum menerapkan pelayanan perawatan dengan berbasis kesehatan. Permasalahan ini ditemui pada Jihan salon dan Irma salon. UNP sebagai institusi pendidikan yang mempunyai tenaga profesional di bidang kecantikan dan kesehatan dapat membantu mitra dalam mengatasi permasalahan dan menjadikan salon mitra sebagai salon kecantikan yang berbasis kesehatan. Khalayak sasaran dalam kegiatan ini adalah Pemilik dan karyawan UKM salon kecantikan di pariaman. Tujuan yang ingin dicapai dalam kegiatan pengabdian ini adalah menjadikan salon mitra sebagai salon kecantikan yang berbasis kesehatan dalam segala pelayanan yang diberikan sehingga dapat memberikan peluang peningkatan kualitas pelayanan lebih baik dan upaya perlindungan konsumen. Pelatihan ini dilakukan dengan metode yang bervariasi seperti ceramah demontrasi, pelatihan, praktek, diskusi dan bimbingan. Materi yang diberikan 1) Memberikan pengetahuan tentang analisa kulit dan kosmetik skincare 2) Mendemontrasikan penerapan personal higiene 3) Demontrasi dan praktek pemakaian APD serta setrilisasi alat 4) Praktek perawatan Facial sesuai SOP 5) Pengaturan ruang yang proposional. Secara garis besar kegiatan ini berjalan lancar dan dapat meningkatkan kualitas pelayananan salon berbasis kesehatan dan upaya perlindungan konsumen.

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Sinclair, Allan. « OPERATOR SPACES (London Mathematical Society Monographs : New Series 23) By EDWARD G. EFFROS and ZHONG-JIN RUAN : 363 pp., £60.00 (LMS members' price £42.00), ISBN 0-19-853482-5 (Clarendon Press, Oxford, 2000). » Bulletin of the London Mathematical Society 33, n^o 6 (novembre 2001) : 758–68. http://dx.doi.org/10.1112/s0024609301278849.

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Zhao, Hui, zhiyuan jiang, zhiyu wang, yujie chang et shunyi ruan. « Abstract 5665 : LILRB2 mediates the immune escape of breast tumor cells by degrading HLA-A ». Cancer Research 82, n^o 12_Supplement (15 juin 2022) : 5665. http://dx.doi.org/10.1158/1538-7445.am2022-5665.

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Abstract Breast cancer has now risen to the number one cancer in the world, posing a great threat to human health. LILRB2 (leukocyte immunoglobulinlike receptor B2) is an important immunosuppressive receptor protein, which is mainly expressed in myeloid cells, such as macrophages and dendritic cells. At present, we have found clinically that patients with breast cancer bone and bone marrow metastasis have higher expression of LILRB2. In our research, we used Western blotting, real-time fluorescent quantitative Polymerase Chain Reaction (RT-PCR), flow cytometry, and other experimental methods to explore the expression and function of LILRB2 in breast cancer cells. In our research, we found that LILRB2does increase expression in breast cancer cells, therefore, we want to explore the role of LILRB2 in breast cancer cells. we find that LILRB2 will accelerate the proliferation of tumor cells and increase their migration ability. We tested the related signal pathways and found that LILRB2 can promote the enhancement of the NF-Kb signal pathway. Further, we have done related LILRB2 correlation analysis and found that LILRB2 can reduce human leukocyte antigen-A (HLA-A) Expression. Next, we tested the changes in the level of major histocompatibility complex (MHC-1) related mRNA and found that its mRNA expression increased, which was inconsistent with the decrease in its protein level we observed. Therefore, we used the proteasome inhibitor MG132 for treatment, and the results showed after adding MG132, the decrease in HLA-A expression caused by overexpression of LILRB2 was restored. Next, we knocked down the breast cancer cell line of membrane-associated ring finger (MARCH9). After we knocked down MARCH9, transfection of LILRB2 did not increase the ubiquitination of HLA-A. Therefore we show that LILRB2 can mediate the post-translational modification of HLA-A via MARCH9, which in turn mediates the degradation ofHLA-A. In conclusion, our research shows that LILRB2 maybe a candidate of clinical target for the treatment of breast cancer, preventing possible bone and bone marrow metastasis from breast cancer. Citation Format: Hui Zhao, zhiyuan jiang, zhiyu wang, yujie chang, shunyi ruan. LILRB2 mediates the immune escape of breast tumor cells by degrading HLA-A [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5665.

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Choudhari, Omkar Kalidasrao, Sonam Spalgis et Umesh Chandra Ojha. « Cotrimoxazole as adjuvant therapy in critical ill COVID 19 patients ». Journal of Ideas in Health 3, Special1 (25 septembre 2020) : 196–97. http://dx.doi.org/10.47108/jidhealth.vol3.issspecial1.60.

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The ongoing pandemic of COVID-19 has forced us to consider using available drugs in the shortfall of vaccines and established treatment. Cotrimoxazole is one of the oldest drugs presently used in the prevention and treatment of opportunistic infections in the human immune deficiency virus (HIV) etc. It is a combination of two drugs Trimethoprim and Sulfamethoxazole. This cost-effective old drug is well tolerated among the population with the concomitant use of folic acid; moreover, it also looks after the secondary infections. To conclude, Cotrimoxazole can be used as critically ill COVID-19 patients. References Ruan Q, Yang K, Wang W, Jiang L, Song J. Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Intensive care Med. 2020;46(5): 846–48. https://doi.org/10.1007/s00134-020-05991-x Rozin A, Schapira D, Braun-Moscovici Y, Nahir AM. Cotrimoxazole treatment for rheumatoid arthritis. Semin Arthritis Rheum. 2001;31(2):133-41. Bourke CD, Gough EK, Pimundu G, Shonhai A, Berejena C, Terry L, et al. Cotrimoxazole reduces systemic inflammation in HIV infection by altering the gut microbiome and immune activation. Sci Transl Med. 2019;11(486): eaav0537. https://doi.org/10.1126/scitranslmed. aav0537 Liu B, Li M, Zhou Z, Guan X, Xiang Y. Can we use interleukin-6 (IL-6) blockade for coronavirus disease 2019 (COVID-19)-induced cytokine release syndrome (CRS)? J Autoimmun. 2020; 111:102452. https://doi.org/10.1016/j.jaut.2020.102452 Vickers IE, Smikle MF. The immunomodulatory effect of antibiotics on the secretion of tumour necrosis factor alpha by peripheral blood mononuclear cells in response to Stenotrophomonas maltophilia stimulation. West Indian Med J. 2006;55(3):138-41. https://doi.org/10.1590/s0043-31442006000300002 Onyebuagu PC, Kiridi K, Pughikumo DT. Effects of septrin administration on blood cells parameters in humans. Int. J. Basic Appl. Innov. Res, 2014;3(1): 14 -8. https://www.ajol.info/index.php/ijbair/article/view/104688 Ho JMW, Juurlink DN. Considerations when prescribing trimethoprim– sulfamethoxazole. CMAJ. 2011; 183(16):1851-8. https://doi.org/10.1503/cmaj.111152 Mahan CS, Walusimbi M, Johnson DF, Lancioni C, Charlebois E, Baseke J, et al. Tuberculosis treatment in HIV infected Ugandans with CD4 counts .350 cells/mm3 reduces immune activation with no effect on HIV load or CD4 count. PLoS one.2010;5(2): e9138. https://doi.org/10.1371/journal.pone.0009138 Varney VA, Smith B, Quirke G, Parnell H, Ratnatheepan S, Bansal AS, et al. P49 the effects of oral cotrimoxazole upon neutrophil and monocyte activation in patients with pulmonary fibrosis and healthy controls; does this relate to its action in idiopathic pulmonary fibrosis. Thorax. 2017;72: A109. http://dx.doi.org/10.1136/thoraxjnl-2017-210983.191

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Zhao, Hui, Yujie Chang, Zhiyuan Jiang, Zhiyu Wang et Shunyi Ruan. « Abstract CT543 : 18F-FDG PET/CT detects potentially malignant bone metastases in patients with suspected lesions : A prospective clinical trial ». Cancer Research 82, n^o 12_Supplement (15 juin 2022) : CT543. http://dx.doi.org/10.1158/1538-7445.am2022-ct543.

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Abstract Tumor metastasis to the skeleton affects over 70% cancer patients, more than any other site of metastasis Skeletal related events (SREs) included spinal cord compression, fracture, bone radiation or surgery, and tumor-related hypercalcemia are severe complications of bone metastases, which impair patients life quality and require particular treatments The gold standard for the definitive diagnosis is still pathological examination, which needs pre-biopsy imaging review to improve the diagnosis efficacy Classic imaging review method for being CT (Computed Tomography) and 18F-FDG PET/CT Research has shown that 18F-FDG PET/CT is superior to CT in detecting bone metastasis, however, it is not validated by a prospective study Besides, as SUVmax is a metabolic parameter in oncology imaging, we can serve as a reliable semiquantitative indicator to differentiate bone lesions We conducted a prospective clinical trial at Shanghai Sixth People’s Hospital Inclusion criteria were as follows: referred for diagnostic biopsy on a suspicion of metastatic disease Exclusion criteria included contraindications for biopsy 205 patients participated in the cohort study, then were randomized into PET/CT and CT group They underwent 18F-FDG PET/CT and CT separately to confirm accurate location, then both received CT-guided bone biopsy to confirm The sensitivity, specificity and accuracy were calculated In PET/CT group, malignant bone metastases were found in 83/137 patients and biopsies proved 80 were actual metastases In CT group, 48 malignant bone metastases were spotted and 47 were truly decisive The sensitivity, specificity and accuracy of 18F-FDG PET/CT and CT are 99% vs 87%, 95% vs 93%, and 97% vs 88% A chi-square test was utilized to analyze The sensitivity of 18F-FDG PET/CT is better than CT (P=0 0065), but the specificity and accuracy had no differences, indicating 18F-FDG PET/CT could detect more bone metastatic lesions potentially than CT We also found metastasis malignant lesions had higher bone SUVmax than benign (median 9 3 vs 4 25, p <0 001) ROC curves were asked to evaluate the differential efficacy of SUVmax In all 137 patients, the SUVmax 6 3 showed an AUC of 0 874 to predict malignant metastases Our research shows that [18F]FDG PET/CT has greater sensitivity in detecting malignant bone metastases than CT, and SUVmax can be different criteria for determining the malignancy of bone lesions Citation Format: Hui Zhao, Yujie Chang, Zhiyuan Jiang, Zhiyu Wang, Shunyi Ruan. 18F-FDG PET/CT detects potentially malignant bone metastases in patients with suspected lesions: A prospective clinical trial [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr CT543.

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Sazinsky, Steve, Phuong Nguyen, Mohammad Zafari, Ryan Phennicie, Joe Wahle, Veronica Komoroski, Kathryn Rooney et al. « 886 Targeting VSIG4, a novel macrophage checkpoint, repolarizes suppressive macrophages which induces an inflammatory response in primary cell in vitro assays and fresh human tumor cultures ». Journal for ImmunoTherapy of Cancer 9, Suppl 2 (novembre 2021) : A928. http://dx.doi.org/10.1136/jitc-2021-sitc2021.886.

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BackgroundVSIG4 (V-set immunoglobulin-domain-containing 4) is a B7 family related protein with known roles as a complement receptor involved in pathogen clearance as well as a negative regulator of T cell activation by an undetermined mechanism.1–3 VSIG4 is expressed in tumor associated macrophages (TAMs) with exquisite specificity. In cancer, increased expression of VSIG4 has been associated with worse survival in multiple indications, including non-small cell lung cancer, multiple myeloma, ovarian cancer, and glioma, suggesting an important role in tumor immune evasion.3–6 Based upon computational analysis of transcript data across thousands of primary cancer and normal tissue samples, we hypothesized that VSIG4 has an important regulatory role in promoting M2-like immune suppressive macrophages in the tumor microenvironment, and that targeting VSIG4 via a monoclonal antibody could relieve VSIG4-mediated macrophage suppression by repolarizing TAMs to an inflammatory phenotype capable of coordinating an anti-tumor immune response.MethodsThe ability of anti-VSIG4 antibodies to repolarize M2-like macrophages and induce T cell activation was assessed in vitro and ex vivo, by measuring production of inflammatory mediators. In vitro assays were performed primarily with M-CSF plus IL-10 driven monocyte-derived M2c macrophages from healthy donors. Ex vivo assays were performed with fresh, patient-derived tumor samples in culture. To determine whether targeting VSIG4 can lead to an anti-tumor effect in vivo, syngeneic mouse models were dosed with anti-mouse VSIG4 antibodies and characterized for changes in tumor volume and immune cell populations.ResultsIn in vitro and ex vivo assays anti-VSIG4 antibodies repolarize M2 macrophages and induce an immune response culminating in T cell activation. Targeting VSIG4 upregulates pro-inflammatory cytokines in M2c macrophages, as well as upregulates pro-inflammatory myeloid-derived cytokines and T cell-derived cytokines in M2c macrophages co-cultured with autologous T cells in the presence of staphylococcal enterotoxin B (SEB) activation. To assess targeting VSIG4 in a relevant translational model, fresh, patient-derived tumor samples were treated ex vivo with anti-VSIG4. Across multiple tumor types, anti-VSIG4 treatment resulted in a significant upregulation of cytokines involved in TAM repolarization and T cell activation, and chemokines involved in immune cell recruitment, at levels greater than observed by treatment with anti-PD-1 or a clinical macrophage repolarizing agent (anti-ILT-4). In vivo, tumor growth inhibition is observed in syngeneic mouse models dosed with anti-mouse-VSIG4 alone and in combination with anti-PD-1.ConclusionsTaken together, these data suggest that VSIG4 represents a promising new target capable of stimulating an anti-cancer response via multiple key immune mechanisms.Referencesvan Lookeren Campagne M, Verschoor A. Pathogen clearance and immune adherence “revisited”: immuno-regulatory roles for CRIg. Semin Immunol 2018;37:4–11.Xu S, Sun Z, Li L, Liu J, He J, Song D, Shan G, Liu H, Wu X. Induction of T cells suppression by dendritic cells transfected with VSIG4 recombinant adenovirus. Immunol Lett 2010;128(1):46–50.Liao Y, Guo S, Chen Y, Cao D, Xu H, Yang C, Fei L, Ni B, Ruan Z. VSIG4 expression on macrophages facilitates lung cancer development. Lab Invest 2014;94(7):706–715.Roh J, Jeon Y, Lee A, Lee S, Kim Y, Sung C, Park C, Hong J, Yoon D, Suh C, Huh J, Choi I, Park C. The immune checkpoint molecule V-set Ig domain-containing 4 is an independent prognostic factor for multiple myeloma. Oncotarget 2017;8(35):58122–58132.Xu T, Jiang Y, Yan Y, Wang H, Lu C, Xu H, Li W, Fu D, Lu Y, Chen J. VSIG4 is highly expressed and correlated with poor prognosis of high-grade glioma patients. Am J Transl Res 2015;7(6):1172–1180.Byun J, Jeong D, Choi I, Lee D, Kang M, Jung K, Jeon Y, Kim Y, Jung E, Lee K, Sung M, Kim K. The significance of VSIG4 expression in ovarian cancer. Int J Gynecol Cancer 2017;27(5):872–878.Ethics ApprovalAll legal and ethical requirements were met with regards to the humane treatment of animals described in the study. The animal study was conducted in compliance with CRL IACUC under IACUC No. I033.

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Ainiyah, Nur. « PENGARUH MODEL PEMBELAJARAN KOOPERATIF TIPE TALKING CHIPS TERHADAP KETERAMPILAN SOSIAL DAN HASIL BELAJAR IPS SISWA KELAS IV SEKOLAH DASAR ». Jurnal Review Pendidikan Dasar : Jurnal Kajian Pendidikan dan Hasil Penelitian 5, n^o 1 (11 janvier 2019) : 868. http://dx.doi.org/10.26740/jrpd.v5n1.p868-874.

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ABSTRACTThe aims of this research is to know the effect of cooperative learning model of talking chips to social skill fourth grade student of Elementary School and to know the effect of cooperative learning model of talking chips to learning outcomes of Social Studies fourth grade student of Elementary School. The subject of this research is fourth grade student in SDN Kedungsumur I as control class and fourth grade student in SDN Kedungsumur III as experiment class school year 2015/2016. In this research using quasi experimental design with form of research is nonequivalent control group design. The research data was obtained as follows: social skills of student in pretest at experiment class there is nothing different with control class. This condition was shown with thitungscore (0.613) < ttabel (1.686) with mean score in experiment class is 58.3500 in control class 57.0500. While social skills of student in posttest at experiment class there is different with control class. This condition was shown with thitungscore (14.081) > ttabel (1.686) with mean score in experiment class is 86.5500 and in control class 63.3500. So, there are effect of the cooperative learning model of talking chips to social skills of student. After that for second hypothesis testing was showed that student learning outcomes in pretest at experiment class there is nothing different with control class. This condition was shown with thitung score (0.968) < ttabel (1.686) with mean score in experiment class is 60.7000 and in control class is 57.3500. While student learning outcomes in posttest at experiment class there is different with control class. This condition was shown with thitungscore (6.798) > ttabel (1.686) with mean score in experiment class is 89.6500 and in control class 74.1000. So, there are effect of cooperative learning model of talking chips to student learning outcomes.Based on the result of analyze data, it can be concluded that cooperative learning model of talking chips has an effect to student social skills and student learning outcomes in significant. Keyword: Talking Chips, Social Skill, Learning Outcomes. ABSTRAKTujuan penelitian ini adalah untuk menganalisis pengaruh model pembelajaran kooperatif tipe talking chips terhadap keterampilan sosial siswa kelas IV Sekolah Dasar dan untuk menganalisis pengaruh model pembelajaran kooperatif tipe talking chips terhadap hasil belajar IPS siswa kelas IV Sekolah Dasar. Subjek dalam penelitian ini adalah siswa kelas IV SDN Kedungsumur I sebagai kelas kontrol dan IV SDN Kedungsumur III sebagai kelas eksperimen tahun pelajaran 2015/2016. Dalam penelitian ini menggunakan quasi experimental design dengan bentuk desain penelitian nonequivalent control group design. Data hasil penelitian yang diperoleh sebagai berikut: keterampilan sosial siswa pada saat pretest di kelas eksperimen tidak ada perbedaan dengan kelas kontrol. Hal ini ditunjukkan dengan nilai thitung(0.613) < ttabel (1.686) dengan nilai mean pada kelas eksperimen sebesar 58.3500 dan pada kelas kontrol sebesar 57.0500. Sedangkan keterampilan sosial siswa pada saat posttest di kelas eksperimen ada perbedaan dengan kelas kontrol. Hal ini ditunjukkan dengan nilai thitung(14.081) > ttabel (1.686) dengan nilai mean pada kelas eksperimen sebesar 86.5500 dan pada kelas kontrol sebesar 63.3500. Jadi, ada pengaruh model pembelajaran kooperatif tipe talking chips terhadap keterampilan sosial siswa. Kemudian untuk pengujian hipotesis kedua menunjukkan bahwa hasil belajar siswa pada saat pretest di kelas eksperimen tidak ada perbedaan dengan kelas kontrol. Hal ini ditunjukkan dengan nilai thitung(0.968) < ttabel (1.686) dengan nilai mean pada kelas eksperimen sebesar 60.7000 dan pada kelas kontrol yaitu 57.3500. Sedangkan hasil belajar siswa pada saat posttest di kelas eksperimen ada perbedaan dengan kelas kontrol. Hal ini ditunjukkan dengan nilai thitung(6.798) > ttabel (1.686) dengan nilai mean pada kelas eksperimen sebesar 89.6500 dan pada kelas kontrol sebesar 74.1000. Jadi, ada pengaruh model pembelajaran kooperatif tipe talking chips terhadap hasil belajar siswa. Berdasarkan hasil analisis data, dapat disimpulkan bahwa model pembelajaran kooperatif tipe talking chips berpengaruh terhadap keterampilan sosial siswa dan hasil belajar siswa secara signifikan. Kata Kunci: Talking Chips, Keterampilan Sosial, Hasil Belajar.Fathurrohman, Muhammad. (2015). Model-Model Pembelajaran Inovatif: Alternatif Desain Pembelajaran yang Menyenangkan. Jogjakarta: Ar-Ruzz Media.Gillies, Robyn M, dkk. (2008). The Teacher’s Role in Implementing Cooperative Learning in the Classroom. USA: Springer Science.Gregoriadis, Athanasios, dkk. (2013). Evaluating Preschooles’ Social Skills: The Impact of a Physical Education Program from the Parents’ Perspective. International Journal of Humanities and Social Science.Vol. 3 No. 10, pp. 40-51.Huda, Miftahul. (2012). Cooperative Learning; Metode, Teknik, Struktur dan Model Terapan. Yogyakarta: Pustaka Pelajar.Imron, Ilmawati Fahmi. (2014). Pengaruh Penerapan Pendekatan Scientific dengan Model Pembelajaran Berbasis Masalah terhadap Berpikir Kritis dan Keterampilan Sosial Siswa Materi Manusia dan Lingkungannya di Sekolah Dasar (Tesis tidak dipublikasikan). Universitas Negeri Surabaya.Isjoni. (2013). Cooperative Learning. Pekanbaru: Alfabeta.Jihad, Asep dan Abdul Haris. (2012). Evaluasi Pembelajaran. Yogyakarta: Multi Pressindo.Kunandar. (2014). Penilaian Autentik (Penilaian Hasil Belajar Peserta Didik Berdasarkan Kurikulum 2013). Jakarta: Rajawali Pers.Kurniawan, Deni. (2014). Pembelajaran Terpadu Tematik (Teori, Praktik, dan Penilaian). Bandung: Alfabeta.Lie, Anita. (2008). Cooperative Learning (Mempraktikkan Cooperative Learning di Ruang-ruang Kelas). Jakarta: PT. Grasindo.Sapriya. (2009). Pendidikan IPS Konsep dan Pembelajaran. Bandung: PT. Rosda Karya.Subroto, Waspodo Tjipto. (2014). Bahan Pembelajaran Ilmu Pengetahuan Sosial di Sekolah Dasar. Surabaya: Unesa University Press.Sugiyono. (2013). Metode Penelitian Pendidikan Pendekatan Kuantitatif, Kualitatif, dan R&D. Bandung: Alfabeta.Yeo, Kee Jiar dan Kie Yin Teng. (2015). Social Skills Deficits in Autism: A Study among Students with Autism Spectrum Disorder in Inclusive Classrooms. Universal Journal of Educational Research. Vol. 3 No.12, pp. 1001-1007.

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Domashevskaya, Evelina P., Van Tu Chan, Anatoly N. Lukin, Sergey V. Sitnikov et Oleg V. Stognay. « МЕЖАТОМНЫЕ СВЯЗИ В АМОРФНЫХ КОМПОЗИТАХ (CoFeB)x(TiO2)1–x C РАЗНЫМ СОДЕРЖАНИЕМ МЕТАЛЛИЧЕСКОЙ И ДИЭЛЕКТРИЧЕСКОЙ КОМПОНЕНТ ПО ДАННЫМ ИК-СПЕКТРОСКОПИИ ». Kondensirovannye sredy i mezhfaznye granitsy = Condensed Matter and Interphases 21, n^o 3 (26 septembre 2019) : 374–84. http://dx.doi.org/10.17308/kcmf.2019.21/1151.

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Методом ионно-лучевого распыления двух мишеней (одна из сплава CoFeB, вторая из TiO2) на вращающуюся ситалловую подложку получена серия образцов с градиентом состава и толщины композита (CoFeB)x(TiO2)1–x. На дифрактограммах aморфных композитов обнаружено гало, соответствующее среднему межатомному расстоянию, близкому по величине к значениям межплоскостных расстояний самых интенсивных дифракционных линий в сплавах CoFe. Методом ИК-спектроскопии проведена идентификация мод, соответствующих межатомным связям в аморфных композитах (CoFeB)x(TiO2)1–x различного состава. Установлено наличие связей с кислородом всех элементов композита Fe–O, Co–O, Ti–O, B-O, а также образование промежуточных химических связей Ti–O–B, Ti–O–Co между атомами диэлектрической и металлической компонент композита. На основе полученных данных предложена модель аморфных композитов (Co45Fe45B10)x(TiO2)1–x, в которой металлические частицы представляются в виде ядра из металлических кластеров CoFe с оболочкой из оксидов и боридов/оксиборидов d-металлов, распределенных в диэлектрической матрице диоксида титана TiO2–х. ИСТОЧНИК ФИНАНСИРОВАНИЯРабота выполнена при поддержке Минобрнауки России в рамках государственного заданияВУЗам в сфере научной деятельности на 2017–2019 годы. Проект № 3.6263.2017/ВУ. REFERENCES Zolotukhin I. V., Kalinin Yu. E., Stognay O. V. New directions of physical materials science. Voronezh, Voronezh State University Publ., 2000, 456 p. (in Russ.) Gridnev S. A., Kalinin Yu. E., Sitnikov A. V., Stognay O.V. Nonlinear phenomena in nano- and microheterogeneous systems. Moscow, BINOM. Lab knowledge Publ., 2012, 352 p. (in Russ.) Stognay O. V. Electric transport and magnetic properties of amorphous nano-granulated metal-dielectric composites. Doc. Sci. diss, Voronezh, 2004, 280 p. Diany B., Serious V.S., Metin, Parkin S., Gurney B. A., Baumgart P., Wilhoit D. R. Magnetotransport properties of magnetically soft spin-valve structures. J. Appl. Phys., 1991, v. 69(9), pp. 4774–4779. https://doi.org/10.1063/1.348252 Kalinin Yu. E., Sitnikov A. V., Stognei O. V., Zolotukhin I.V., Neretin P.V. Electrical properties and giant vagnetoresistance of the CoFeB–SiO2 amorphous granular composites. Materials Science and Engineering: A, 2001, v. 304–306, pp. 941–945. https://doi.org/10.1016/s0921-5093(00)01606-3 Kotov L. N., Turkov V. K., Vlasov V. S., Lasek M. P., Kalinin Yu. E., Sitnikov A. V. Conductive, magnetic and structural properties of multilayer fi lms. IOP Conf. Series: Materials Science and Engineering, 2013, v. 47. 012027. https://doi.org/10.1088/1757-899X/47/1/012027 Domashevskaya E. P., Storozhilov S. A., Turishchev S. Yu., Kashkarov V. M., Terekhov V. A., Stogney O. V., Kalinin Yu. E., Sitnikov A. V., Molodtsov S. L. XANES and USXES studies of interatomic interactions in (Co41Fe39B20)x(SiO2)1−x nanocomposites. Physics of the Solid State, 2008, v. 50(1), pp. 139–145. https://doi.org/10.1134/S1063783408010253 Shchekochikhin A. V., Domashevskaya E. P., Karpov S. I. Effect of elemental composition based on CoFeB-SiO2 on magnetic and magnetoresistive properties. Kondensirovannye sredy i mezhfaznye granitsy [Condensed Matter and Interphases], 2006, v. 8(1), pp. 64–66. URL: http://www.kcmf.vsu.ru/resources/t_08_1_2006_013.pdf (in Russ.) Domashevskaya E. P., Chan Van Tu, Chernyshev A. V., Lukin A. N. Investigation of the interato mic interaction in multilayer nanostructures (Co45Fe45Zr10/a-Si)40 and (Co45Fe45Zr10/SiO2) by method of IR-spectroscopy and small angle diffraction. Condensed Matter and Interphases, 2017, v. 19(2), pp. 195–204. https://doi.org/10.17308/kcmf.2017.19/192 (in Russ.) JCPDS − International Centrefor Diffraction Data. 2001, no. 51−0740. JCPDS − International Centre for Diffraction Data. 2001, no. 49−1588. JCPDS − International Centre for Diffraction Data. 2001, no. 48−1817. Kongfa Chen, Lihua Fang, Teng Zhang, San Ping Jiang. New zinc andbismuth doped glass sealants with substantially suppressed borondeposition and poisoning for solid oxide fuel cells. J. Mater. Chem. A, 2014, v. 2(43), pp. 18655–18665. https://doi.org/10.1039/c4ta02951h Wenjie Zhang, Bo Yang, Jinlei Chen. Effects of calcination temperature on preparation of borondoped TiO2 by sol-gel method. International Journal of Photoenergy, 2012, v. 2012, pp. 1–8. https://doi.org/10.1155/2012/528637 Rihcard A., Nyquistand R., Kagel O. Infrared Spectra of Inorganic Compounds. New York and London, Academic Press, 1971, 499 p. Milovanov Yu. S., Kuznetsov G. V., Skryshevsky V. A., Stupan S. M. Transport of Charge in Nanocomposite Structures of Silicon-SiO2, Silicon-TiO2. Semiconductors, 2014, v. 48(10), pp. 1335–1341. https://doi.org/10.1134/s1063782614100200 Chetverikova A. G., Maryakhina V. S. Studies of polymineral clay containing three-layer aluminosilicates by physical methods. Bulletin of the Orenburg State University, 2015, no. 1 (176), pp. 250–255. (in Russ.) Shchekochikhin A. V., Domashevskaya E. P., Karpov S. I., Stognei O. V. Interatomic interaction and modes of IR spectra in amorphous nanocomposites (Co45Fe45Zr10)x(SiO2)1–x. Proceedings of Voronezh State University. Series: Physics. Mathematics, 2008, no. 1, pp. 109–114. URL: http://www.vestnik.vsu.ru/pdf/physmath/2008/01/schekochihin.pdf (in Russ.) María E., Pérez Bernal, Ricardo J., Ruano Casero, Vicente Rives. Mixed Oxides Co-Fe Mixed Oxides & Calorie/Calcination of Layered Double. Ceramics– Silikáty, 2004, v. 48(4), pp. 145–154. URL: https://www.irsm.cas.cz/materialy/cs_content/2004/Bernal_CS_2004_0000.pdf Nicholas T. Nolan, Michael K. Seery, Suresh C. Pillai. Spectroscopic investigation of the anatase-torutile transformation of sol-gel synthesised TiO2 photocatalysts // J. of Physical Chemistry C, 2009, v. 113, pp. 16151–16157. https://doi.org/10.1021/jp904358g

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Purba, Natalina, et Martua Reynhat Sitanggang Gusar. « Clean and Healthy Lifestyle Behavior (PHBS Program) for Children with Intellectual Disability ». JPUD - Jurnal Pendidikan Usia Dini 14, n^o 2 (30 novembre 2020) : 275–87. http://dx.doi.org/10.21009/jpud.142.06.

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The achievement of children's quality of life is undoubtedly linked to the development of positive habits that will continue to be practiced in future lives. This can be done by developing awareness and behavior of a balanced clean and healthy lifestyle. The purpose of this study was to determine the increase in the PHBS ability of children. Various efforts have been made so that children with intellectual disabilities can maintain their cleanliness. The efforts made by the teacher are still not maximal so that the delivery of information about PHBS must be completed by another method, namely demonstration. This research was conducted at SDLB 127710 Pematangsiantar5 with an action research method that refers to the Kurt Lewin model. Data collection techniques used purposive sampling and data analysis with the Wilcoxon test. The results showed an increase in understanding of the PHBS of children with intellectual disabilities able to learn SDLB 127710 Pematangsiantar through the demonstration method. This is evidenced by the increase in the score, where the initial assessment was obtained (59%), while in the first cycle, the average score was good (69.9%). In short, the understanding of children with intellectual disabilities being able to learn about PHBS is increased by using the demonstration method. Keywords: Intellectual Disability Children, PHBS program, Demonstration methods References Agarwal, R. (2017). Importancia de la atención primaria de salud en la sociedad. International Journal of Health Sciences, 1(1), 5–9. Aiello, A. E., Coulborn, R. M., Perez, V., & Larson, E. L. (2008). Effect of hand hygiene on infectious disease risk in the community setting: A meta-analysis. American Journal of Public Health, 98(8), 1372–1381. https://doi.org/10.2105/AJPH.2007.124610 Arip, M. pdfo., & Emilyani, D. (2018). Strategy to improve knowledge, attitude, and skill toward clean and healthy life behaviour. International Journal of Social Sciences and Humanities, 2(3), 125–135. https://doi.org/10.29332/ijssh.v2n3.222 Basheer, A., Hugerat, M., Kortam, N., & Hofstein, A. (2017). The effectiveness of teachers’ use of demonstrations for enhancing students’ understanding of and attitudes to learning the oxidation-reduction concept. Eurasia Journal of Mathematics, Science and Technology Education, 13(3), 555–570. https://doi.org/10.12973/eurasia.2017.00632a Bloomfield, S. F., Aiello, A. E., Cookson, B., O’Boyle, C., & Larson, E. L. (2007). The effectiveness of hand hygiene procedures in reducing the risks of infections in home and community settings including handwashing and alcohol-based hand sanitizers. American Journal of Infection Control, 35(10 SUPPL. 1). https://doi.org/10.1016/j.ajic.2007.07.001 Cavanaugh, L. K. (n.d.). Intellectual Disabilities (D. L. Porretta (Ed.); 6 th). Human Kinetics. Chang, Y. J., Lee, M. Y., Chou, L. Der, Chen, S. F., & Chen, Y. C. (2011). A Mobile Wetness Detection System Enabling Teachers to Toilet Train Children with Intellectual Disabilities in a Public School Setting. Journal of Developmental and Physical Disabilities, 23(6), 527–533. https://doi.org/10.1007/s10882-011-9243-3 Cummings, S., Bridgman, T., & Brown, K. G. (2016). Unfreezing change as three steps: Rethinking Kurt Lewin’s legacy for change management. Human Relations, 69(1), 33–60. https://doi.org/10.1177/0018726715577707 Dirjen P2P Kemkes RI. (2019). Rencana Aksi Program Pencegahan Dan Pengendalian Penyakit 2015-2019 ( Revisi I - 2018 ). Rencana AKSI Program P2P 2015-2019, 2019, 86. Flanagan, D. P., Alfonso, V. C., & Hale, J. B. (2010). The Wechsler Intelligence Scale for Children - Fourth Edition in Neuropsychological Practice. Handbook of Pediatric Neuropsychology, January, 397–414. Giridharan, K., & Raju, R. (2017). Impact of Teaching Strategies: Demonstration and Lecture Strategies and Impact of Teacher Effect on Academic Achievement in Engineering Education. International Journal of Educational Sciences, 14(3), 174–186. https://doi.org/10.1080/09751122.2016.11890491 Hooman, N., Safaii, A., Valavi, E., & Amini-Alavijeh, Z. (2013). Toilet training in Iranian children: A cross-sectional study. Iranian Journal of Pediatrics, 23(2), 154–158. Hung, J.-W., Chang, Y.-J., & Han, W.-Y. (2016). Game technology to increase range of motion for adolescents with cerebral palsy: a feasibility study. International Journal on Disability and Human Development, 16(3). https://doi.org/10.1515/ijdhd-2016-0026 Kang, Y. S., & Chang, Y. J. (2019). Using a motion-controlled game to teach four elementary school children with intellectual disabilities to improve hand hygiene. Journal of Applied Research in Intellectual Disabilities, 32(4), 942–951. https://doi.org/10.1111/jar.12587 Kementerian, & Indonesia, R. (2011). Profil Kesehatan Indonesia. Kemenenterian Kesehatan RI. Kesehatan, K. (2011). PHBS di Sekolah. Kementerian Kesehatan Republik Indonesia. Ketut Sudiana, I., Adiputra, N., & Budi Adnyana, P. (2020). Integrative Health Thematic Strategy Increases Learning Outcomes and Students ’Clean and Healthy Living Behaviors. Journal of Physics: Conference Series, 1503(1). https://doi.org/10.1088/1742-6596/1503/1/012050 Koh, W. M., Bogich, T., Siegel, K., Jin, J., Chong, E. Y., Tan, C. Y., Chen, M. I. C., Horby, P., & Cook, A. R. (2016). The epidemiology of hand, foot and mouth disease in Asia: A systematic review and analysis. Pediatric Infectious Disease Journal, 35(10), e285–e300. https://doi.org/10.1097/INF.0000000000001242 Kroeger, K., & Sorensen, R. (2010). A parent training model for toilet training children with autism. Journal of Intellectual Disability Research, 54(6), 556–567. https://doi.org/10.1111/j.1365-2788.2010.01286.x Laporan Akuntabilitas Kinerja Kementerian Kesehatan tahun 2014. (n.d.). Lee, R. L. T., & Lee, P. H. (2014). To evaluate the effects of a simplified hand washing improvement program in schoolchildren with mild intellectual disability: A pilot study. Research in Developmental Disabilities, 35(11), 3014–3025. https://doi.org/10.1016/j.ridd.2014.07.016 Lee, R. L. T., Leung, C., Tong, W. K., Chen, H., & Lee, P. H. (2015). Comparative efficacy of a simplified handwashing program for improvement in hand hygiene and reduction of school absenteeism among children with intellectual disability. American Journal of Infection Control, 43(9), 907–912. https://doi.org/10.1016/j.ajic.2015.03.023 Levato, L. E., Aponte, C. A., Wilkins, J., Travis, R., Aiello, R., Zanibbi, K., Loring, W. A., Butter, E., Smith, T., & Mruzek, D. W. (2016). Use of urine alarms in toilet training children with intellectual and developmental disabilities: A review. Research in Developmental Disabilities, 53–54, 232–241. https://doi.org/10.1016/j.ridd.2016.02.007 Noah Ekeyi, D. (2013). Effect of Demonstration Method of Teaching on Students’ Achievement in Agricultural Science. World Journal of Education, 3(6), 1–7. https://doi.org/10.5430/wje.v3n6p1 Pedoman Umum Program Indonesia Sehat dengan Pendekatan Keluarga. (2015). Kementerian Kesehatan Republik Indonesia. Purba, N., Handini, M. C. H., & Yetti, E. (2018). Development of Media Vocabulary Cards to Improve the Speech Competence of Children with Intellectual Disabilities. 6. Puspita, W. A., Sulistyorini, M. P., & Wibowo, B. (2020). Learning Clean, Healthy and Safe Life Behavior in Inclusive Early Childhood Education. 454(Ecep 2019), 270–274. https://doi.org/10.2991/assehr.k.200808.053 Putri, R. M., Rosdiana, Y., & Nisa, A. C. (2019). Application of Clean and Healthy Living Behavior (PHBS) From The Household Knowledge and Attitude Study. Journal Of Nursing Practice, 3(1), 39–49. https://doi.org/10.30994/jnp.v3i1.64 Rosenberg, N. E., Schwartz, I. S., & Davis, C. A. (2010). Evaluating the utility of commercial videotapes for teaching hand washing to children with autism. Education and Treatment of Children, 33(3), 443–455. https://doi.org/10.1353/etc.0.0098 Ruan, F., Yang, T., Ma, H., Jin, Y., Song, S., Fontaine, R. E., & Zhu, B. P. (2011). Risk factors for hand, foot, and mouth disease and herpangina and the preventive effect of hand-washing. Pediatrics, 127(4). https://doi.org/10.1542/peds.2010-1497 Shen, K., Yang, Y., Wang, T., Zhao, D., Jiang, Y., Jin, R., Zheng, Y., Xu, B., Xie, Z., Lin, L., Shang, Y., Lu, X., Shu, S., Bai, Y., Deng, J., Lu, M., Ye, L., Wang, X., Wang, Y., & Gao, L. (2020). Diagnosis, treatment, and prevention of 2019 novel coronavirus infection in children: experts’ consensus statement. World Journal of Pediatrics, 16(3), 223–231. https://doi.org/10.1007/s12519-020-00343-7 Steenkamp, L., Williams, M., Ronaasen, J., Feeley, A., Truter, I., & Melariri, P. (2020). Handwashing knowledge and practices among caregivers of pre-school children in underprivileged areas of Nelson Mandela Bay. South African Journal of Clinical Nutrition, 0(0), 1–5. https://doi.org/10.1080/16070658.2020.1769336 van Nunen, K., Kaerts, N., Wyndaele, J. J., Vermandel, A., & van Hal, G. V. (2015). Parents’ views on toilet training (TT): A quantitative study to identify the beliefs and attitudes of parents concerning TT. Journal of Child Health Care, 19(2), 265–274. https://doi.org/10.1177/1367493513508232 Walpole, R. E. (1955). Pengantar Statistika. Gramedia.

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Seredin, Pavel V., Dmitry L. Goloshchapov, Kirill A. Nikitkov, Vladimir M. Kashkarov, Yury A. Ippolitov et Vongsvivut Jitraporn (Pimm). « Применение синхротронной ИК-микроспектроскопии для анализа интеграции биомиметических композитов с нативной твердой тканью зуба человека ». Kondensirovannye sredy i mezhfaznye granitsy = Condensed Matter and Interphases 21, n^o 2 (14 juin 2019) : 262–77. http://dx.doi.org/10.17308/kcmf.2019.21/764.

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В данной работе продемонстрирована возможность применения ИК-микроспектроскопии для многомерной визуализации и анализа интеграции с нативными твердыми тканями зуба человека нового поколения биомиметических материалов, воспроизводящих минералорганический комплекс эмали и дентина.На основе ИК-картирования интенсивности конкретной функциональной молекулярной группы с использованием синхротронного излучения найдены и визуализированы характеристические особенности биомиметического переходного слоя в межфазной области эмаль/стоматологический материал и определено расположение функциональных групп, отвечающих процессам интеграции биомиметического композита REFERENCES Rohr N., Fischer J. Tooth surface treatment strategies for adhesive cementation // The Journal of Advanced Prosthodontics, 2017, v. 9(2), pp. 85–92. https://doi.org/10.4047/jap.2017.9.2.85 Pereira C. N. de B., Daleprane B., Miranda G. L. P. de, Magalhães C. S. de, Moreira A. N. 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S., Weir M. D., Rodrigues L. K. A., Xu H. H. K. Novel calcium phosphate nanocomposite with caries-inhibition in a human in situ model // Dental Materials, 2013, v. 29(2), pp. 231–240. https://doi.org/10.1016/j.dental.2012.10.010 Wu X.-T., Mei M., Li Q.-L., Cao C., Chen-L., Xia R., Zhang Z.-H., Chu C. A Direct Electric Field-Aided Biomimetic Mineralization System for Inducing the Remineralization of Dentin Collagen Matrix // Materials, 2015, v. 8(12), pp. 7889–7899. https://doi.org/10.3390/ ma8115433 Barghamadi H., Atai M., Imani M., Esfandeh M. Effects of nanoparticle size and content on mechanical properties of dental nanocomposites: experimental versus modeling // Iranian Polymer Journal, 2015, v. 24. (10), pp. 837–848. https://doi.org/10.1007/s13726-015-0369-5 Wang H., Xiao Z., Yang J., Lu D., Kishen A., Li Y., Chen Z., Que K., Zhang Q., Deng X., Yang X., Cai Q., Chen N., Cong C., Guan B., Li T., Zhang X. Oriented and Ordered Biomimetic Remineralization of the Surface of Demineralized Dental Enamel Using HAP@ ACP Nanoparticles Guided by Glycine // Scientifi c Reports, 2017, v. 7(1), рр. 1-13. https://doi.org/10.1038/srep40701 Wu X., Zhao X., Li Y., Yang T., Yan X., Wang K. In situ synthesis carbonated hydroxyapatite layers on enamel slices with acidic amino acids by a novel twostep method // Materials Science & Engineering. C, Materials for Biological Applications, 2015, v. 54, pp. 150–157. httsp://doi.org/10.1016/j.msec.2015.05.006 Aljabo A., Abou Neel E. A., Knowles J. C., Young A. M. Development of dental composites with reactive fi llers that promote precipitation of antibacterial-hydroxyapatite layers // Materials Science and Engineering: C, 2016, v. 60, pp. 285–292. https://doi.org/10.1016/j.msec.2015.11.047 Wang P., Liu P., Peng H., Luo X., Yuan H., Zhang J., Yan Y. Biocompatibility evaluation of dicalcium phosphate/calcium sulfate/poly (amino acid) composite for orthopedic tissue engineering in vitro and in vivo // Journal of Biomaterials Science. Polymer Edition, 2016, v. 27(11), pp. 1170–1186. https://doi.org/10.1080/09205063.2016.1184123 Lübke A., Enax J., Wey K., Fabritius H.-O., Raabe D., Epple M. Composites of fl uoroapatite and methylmethacrylate-based polymers (PMMA) for biomimetic tooth replacement // Bioinspiration & Biomimetics, 2016, v. 11(3), pp. 035001. https://doi.org/10.1088/1748-3190/11/3/035001 Sa Y., Gao Y., Wang M., Wang T., Feng X., Wang Z., Wang Y., Jiang T. Bioactive calcium phosphate cement with excellent injectability, mineralization capacity and drug-delivery properties for dental bio- mimetic reconstruction and minimum intervention therapy. RSC Advances, 2016, v. 6(33), pp. 27349–27359. https://doi.org/10.1039/C6RA02488B Adachi T., Pezzotti G., Yamamoto T., Ichioka H., Boffelli M., Zhu W., Kanamura N. Vibrational algorithms for quantitative crystallographic analyses of hydroxyapatite-based biomaterials: II, application to decayed human teeth // Analytical and Bioanalytical Chemistry, 2015, v. 407(12), pp. 3343–3356. https://doi.org/10.1007/s00216-015-8539-z Mitić Ž., Stolić A., Stojanović S., Najman S., Ignjatović N., Nikolić G., Trajanović M. Instrumental methods and techniques for structural and physicochemical characterization of biomaterials and bone tissue: A review // Materials Science and Engineering: C, 2017, v. 79, pp. 930–949. https://doi.org/10.1016/j.msec.2017.05.127 Optical spectroscopy and computational methods in biology and medicine / Ed. by Barańska M., Dordrecht: Springer, 2014, 540 p. URL: http://link.springer.com/10.1007/978-94-007-7832-0 Hędzelek W., Marcinkowska A., Domka L., Wachowiak R. Infrared Spectroscopic Identifi cation of Chosen Dental Materials and Natural Teeth // Acta Physica Polonica A, 2008, v. 114(2), pp. 471–484. https://doi.org/10.12693/APhysPolA.114.471 Vongsvivut J., Perez-Guaita D., Wood B. R., Heraud P., Khambatta K., Hartnell D., Hackett M. J., Tobin M. J. Synchrotron macro ATR-FTIR microspectroscopy for high-resolution chemical mapping of single cells // The Analyst, 2019, v. 144(10), pp. 3226–3238. https://doi.org/10.1039/c8an01543k Seredin P., Goloshchapov D., Ippolitov Y., Vongsvivut P. Pathology-specifi c molecular profi les of saliva in patients with multiple dental caries—potential application for predictive, preventive and personalised medical services // EPMA Journal, 2018, v. 9(2), pp. 195–203. https://doi.org/10.1007/s13167-018-0135-9 Dusevich V., Xu C., Wang Y., Walker M. P., Gorski J. P. Identifi cation of a protein-containing enamel matrix layer which bridges with the dentine–enamel junction of adult human teeth // Archives of Oral Biology, 2012, v. 57(12), pp. 1585–1594. https://doi.org/10.1016/j.archoralbio.2012.04.014 Seredin P. V., Kashkarov V. M., Lukin A. N., Goloshchapov D. L., Ippolitov Y. A. Research Hydroxyapatite Crystals and Organic Components of Hard Tooth Tissues Affected by Dental Caries Using Ftir-Microspectroscopy and Xrd-Microdiffraction // Condensed Matter and Interphases, 2013, v. 15(3), с. 224–231. URL: http://www.kcmf.vsu.ru/resources/t_15_3_2013_002.pdf Fattibene P., Carosi A., Coste V. D., Sacchetti A., Nucara A., Postorino P., Dore P. A comparative EPR, infrared and Raman study of natural and deproteinated tooth enamel and dentin // Physics in Medicine and Biology, 2005, v. 50(6), pp. 1095. https://doi.org/10.1088/0031-9155/50/6/004 Seredin P., Goloshchapov D., Kashkarov V., Ippolitov Y., Bambery K. The investigations of changes in mineral–organic and carbon–phosphate ratios in the mixed saliva by synchrotron infrared spectroscopy // Results in Physics, 2016, v. 6, pp. 315–321. https://doi.org/10.1016/j.rinp.2016.06.005 Goloshchapov D. L., Kashkarov V. M., Rumyantseva N. A., Seredin P. V., Lenshin A. S., Agapov B. L., Domashevskaya E. P. Synthesis of nanocrystalline hydroxyapatite by precipitation using hen’s eggshell // Ceramics International, 2013, v. 39(4), pp. 4539–4549. https://doi.org/10.1016/j.ceramint.2012.11.050 Goloshchapov D. L., Lenshin A. S., Savchenko D. V., Seredin P.V. Importance of defect nanocrystalline calcium hydroxyapatite characteristics for developing the dental biomimetic composites // Results in Physics, 2019, v. 13, pp. 102158. https://doi.org/10.1016/j.rinp.2019.102158 Nanci A. Ten Cate’s Oral Histology: Development, Structure, and Function. 8th ed., Elsevier Health Sciences, 2013, 400 p. Ippolitov Ju. A. Vozmozhnost’ povyshenija biologicheskoj tropnosti svetootverzhdaemoj bondingovoj sistemy dlja adgezii tverdyh tkanej zuba k plombirovochnomu material [The possibility of increasing the biological tropism of the lightcuring bonding system for adhesion of hard tooth tissues to the filling material]. Volgogradskij nauchno-medicinskij zhurnal, 2010, v. 4 (28), pp. 31–34. URL: https://www.volgmed.ru/uploads/journals/articles/1293119124-bulletin-2010-4-815.pdf Seredin P., Goloshchapov D., Prutskij T., Ippolitov Y. Phase Transformations in a Human Tooth Tissue at the Initial Stage of Caries. PLoS ONE, 2015, v. 10(4), pp. 1–11. https://doi.org/10.1371/journal.pone.0124008 Seredin P. V., Goloshchapov D. L., Prutskij T., Ippolitov Yu. A. A Simultaneous Analysis of Microregions of Carious Dentin by the Methods of Laser- Induced Fluorescence and Raman Spectromicroscopy. Optics and Spectroscopy, 2018, v. 125(5), pp. 803–809. https://doi.org/10.1134/S0030400X18110267 Seredin P. V., Goloshchapov D. L., Prutskij T., Ippolitov Yu. A. Fabrication and characterisation of composites materials similar optically and in composition to native dental tissues. Results in Physics, 2017, v. 7, pp. 1086–1094. https://doi.org/10.1016/j.rinp.2017.02.025

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Chen, Jian, Zhi‐qiang Liang, Can Hu, Yuan Gao, Yong‐kui Wang, Jiang‐wei Yang, Cheng Zhao, Ye‐min Cao et Yong‐bing Cao. « Protection against peripheral artery disease injury by Ruan Jian Qing Mai formula via metabolic programming ». Biotechnology and Applied Biochemistry, 16 mai 2020. http://dx.doi.org/10.1002/bab.1934.

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Zhang, Pei, Zefeng Wang, Yongjia Shi, Guangtao Yao, Yemin Cao et Jiange Zhang. « Effect of the Ruan Jian Qing Mai recipe on wound healing in diabetic mice and prediction of its potential targets ». Combinatorial Chemistry & ; High Throughput Screening 25 (18 avril 2022). http://dx.doi.org/10.2174/1386207325666220418095316.

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Background: The “Ruan Jian Qing Mai (RJQM) recipe” is a traditional Chinese medicine (TCM), which has been found significant curative effects on diabetic ulcers in clinic for a long time. Previous research has shown that RJQM can improve diabetic skin wound healing and promote angiogenesis. However, the active ingredients of RJQM recipe and its pharmacological mechanism of treatment for diabetic skin wound healing still remain unclear.This study aims to investigate the effect of the RJQM recipe on diabetic wound healing, and to identify the possible active ingredients and their mechanism. Method: First, a skin injury model was established in diabetic mice, and wound healing was evaluated by hematoxylin-eosin (HE) staining, quantitative reverse transcription polymerase chain reaction (RT-qPCR), and western blot analysis. Second, the chemical constituents of the RJQM recipe were analyzed and identified by ultrapressure liquid chromatography mass spectrometry (UPLC-MS). Finally, the possible targets of drug treatment for diabetic skin injury were analyzed by network pharmacology and verified by in vitro experiments using cell culture. Results: (1) In the full-thickness skin injury model, the skin wound healing rate and healing area were significantly increased in mice treated with the RJQM recipe compared with those of the model group. The results of immunofluorescence staining showed that the RJQM recipe could increase the expression of VEGF protein and promote the proliferation of vascular smooth muscle cells and the formation of microvessels, and RT-qPCR results found that the mRNA expression of angiogenesis-related factors in the RJQM recipe group was significantly higher than that in the model group. (2) A total of 25 compounds were identified by UPLC-MS. (3) According to the results of network pharmacology, the therapeutic effect of the RJQM recipe on diabetic skin injury may be related to S6 (quercetin), S1 (typhaneoside), S18 (isoliquiritigenin), protein kinase B-α (Akt1), phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1), insulin-like growth factor I receptor (IGF1R), vascular endothelial growth factor-a (VEGF-a), signal transducer and activator of transcription-3 (STAT3) and phosphoinositide 3-kinase-protein kinase B (PI3K-Akt) signaling pathways. Based on the predictions by network pharmacology, we proved that the drug could treat diabetic skin damage by activating the PI3K-Akt-VEGF signaling pathway. Conclusion: The RJQM recipe promotes the formation of granulation tissue during the process of wound healing and exerts a good therapeutic effect on diabetic skin wound healing.

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Londo, Ireine P., et I. Gede Suwetja. « IPTEKS STANDAR PELAYANAN MINIMAL PADA DINAS PEKERJAAN UMUM DAN PENATAAN RUANG DAERAHPROVINSI SULAWESI UTARA. » Jurnal Ipteks Akuntansi Bagi Masyarakat 2, n^o 02 (31 décembre 2018). http://dx.doi.org/10.32400/jiam.2.02.2018.21826.

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Reform in administration of government in Indonesia have cause the occurance of a number important and fundamental changes in governance which ultimately has implication for the implementation of public services in the region. In accordance with the provisions of article 11 and article 14 ofLaw of Year 2004 Number 32 concerning Regional Government, Government Regulation Number 65 of 2005 concerning Guidelines for Preparation and Application of Minumum Standards Service (SPM). The Government Regulation is a reference for the Ministry / Institutions in the preparation of MSS and become reference points for the government regions in implementing SPM (MSS).Basic services in the Minimum Service Standards are compulsory government affairs that are carried out by regional Governments both Provincial and Regional Governments. Government Affairs is obligatory relating to basic services which subsequently becomes the type of SPM, one of which is SPM in the Field Public Works. Types of Basic Services for SPM in Public Works and Spatial Planning for Provincial and District / City Governments are as follows. Provincial government : meeting the needs of bulk drinking water across districts / cities and provision of cross-regency / municipal regional domestic wastewater treatment service Keywords : Minimum Service Standards, Implementation, Government

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Tombokan, Andre Feral Adolf, et Sonny Pangerapan. « IPTEKS PENGAWASAN TERHADAP REALISASI ANGGARAN DENGAN KONSEP GOOD GOVERNANCE DALAM MENCEGAH PRAKTEK KORUPSI DI DINAS PEKERJAAN UMUM DAN PENATAAN RUANG DAERAH PROVINSI SULAWESI UTARA ». Jurnal Ipteks Akuntansi Bagi Masyarakat 2, n^o 02 (31 décembre 2018). http://dx.doi.org/10.32400/jiam.2.02.2018.21827.

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Indonesia’s development depends on managing the budget state revenues and expenditures (APBN) therefore the government must be aware and change his character not to work alone without paying attention the interest or aspirations of the community. The purpose of this research is to know the flow or budget process at the public works agency and spatial planning in north Sulawesi province know the concept of good governance in carrying out supervision of realization budget, and to find out good governance in an effort to prevent corruption practices .this research is a qualitative research approach interpretive . the source of data from this study is primary data in the form of direct interviews, documentation and recording. Technique processing and analysis of data, namely the method of comparison by finding answers fundamental answers to cause and effect by analyzing factors the cause of the occurrence or emergence of a particular phenomenon. The result of this study indicate that the flow and budget process is on the PUPRD office in north Sulawesi, the budget planning process starts from conducting infestation field survey, after conducting surveys and data needed has been fulfilled, the budget calculation is carried out after it is entered planned DPA (budget implementation document) budget activities, after the DPA is published, we switch the process of physical implementation of work, including planning, design and so on,the concept of good governance in doing supervision of government budget realization is responsible for optimize the relationship between input and output. For example, for example public works agency, its input in the form of a budget can still be seen in its performance. Control,focused on how to utilize input minimum to produce the desired output that is in accordance with provisions and quality standards set at the time and quantity as which are desired. Keywords : supervision of budget realization

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Liu, Qiu-Ping, Yu-Ying Chen, Yuan-Yuan Yu, Pei An, Yi-Zhuo Xing, Hong-Xuan Yang, Yin-Jian Zhang et al. « Bie-Jia-Ruan-Mai-Tang, a Chinese Medicine Formula, Inhibits Retinal Neovascularization in Diabetic Mice Through Inducing the Apoptosis of Retinal Vascular Endothelial Cells ». Frontiers in Cardiovascular Medicine 9 (12 juillet 2022). http://dx.doi.org/10.3389/fcvm.2022.959298.

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Proliferative diabetic retinopathy (PDR) is one of the main complications of diabetes, mainly caused by the aberrant proliferation of retinal vascular endothelial cells and the formation of new blood vessels. Traditional Chinese medicines possess great potential in the prevention and treatment of PDR. Bie-Jia-Ruan-Mai-Tang (BJ), a Chinese medicine formula, has a good therapeutic effect on PDR clinically; however, the mechanism of action involved remains unclear. Therefore, we investigated the effect of BJ on PDR through in vitro and in vivo experiments. A diabetic mouse model with PDR was established by feeding a high-fat–high-glucose diet combined with an intraperitoneal injection of streptozotocin (STZ), while high-glucose-exposed human retinal capillary endothelial cells (HRCECs) were employed to mimic PDR in vitro. The in vivo experiments indicated that BJ inhibited the formation of acellular capillaries, decreased the expression of VEGF, and increased the level of ZO-1 in diabetic mice retina. In vitro experiments showed that high glucose significantly promoted cell viability and proliferation. However, BJ inhibited cell proliferation by cycle arrest in the S phase, thus leading to apoptosis; it also increased the production of ROS, decreased the mitochondrial membrane potential, reduced the ATP production, and also reduced the expressions of p-PI3K, p-AKT, and Bcl-xL, but increased the expressions of Bax and p-NF-κB. These results suggest that BJ induces the apoptosis of HRCECs exposed to high glucose through activating the mitochondrial death pathway by decreasing the PI3K/AKT signaling and increasing the NF-κB signaling to inhibit the formation of acellular capillaries in the retina, thus impeding the development of PDR.

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Chavdarov, Anatoliy V. « Special Issue No. – 10, June, 2020 Journal > ; Special Issue > ; Special Issue No. – 10, June, 2020 > ; Page 5 “Quantative Methods in Modern Science” organized by Academic Paper Ltd, Russia MORPHOLOGICAL AND ANATOMICAL FEATURES OF THE GENUS GAGEA SALISB., GROWING IN THE EAST KAZAKHSTAN REGION Authors : Zhamal T. Igissinova,Almash A. Kitapbayeva,Anargul S. Sharipkhanova,Alexander L. Vorobyev,Svetlana F. Kolosova,Zhanat K. Idrisheva, DOI : https://doi.org/10.26782/jmcms.spl.10/2020.06.00041 Abstract : Due to ecological preferences among species of the genus GageaSalisb, many plants are qualified as rare and/or endangered. Therefore, the problem of rational use of natural resources, in particular protection of early spring plant species is very important. However, literary sources analysis only reveals data on the biology of species of this genus. The present research,conducted in the spring of 2017-2019, focuses on anatomical and morphological features of two Altai species : Gagealutea and Gagea minima ; these features were studied, clarified and confirmed by drawings and photographs. The anatomical structure of the stem and leaf blade was studied in detail. The obtained research results will prove useful for studies of medicinal raw materials and honey plants. The aforementioned species are similar in morphological features, yet G. minima issmaller in size, and its shoots appear earlier than those of other species Keywords : Flora,gageas,Altai species,vegetative organs., Refference : I. Atlas of areas and resources of medicinal plants of Kazakhstan.Almaty, 2008. II. Baitenov M.S. Flora of Kazakhstan.Almaty : Ġylym, 2001. III. DanilevichV. G. ThegenusGageaSalisb. of WesternTienShan. PhD Thesis, St. Petersburg,1996. IV. EgeubaevaR.A., GemedzhievaN.G. The current state of stocks of medicinal plants in some mountain ecosystems of Kazakhstan.Proceedings of the international scientific conference ‘”Results and prospects for the development of botanical science in Kazakhstan’, 2002. V. Kotukhov Yu.A. New species of the genus Gagea (Liliaceae) from Southern Altai. Bot. Journal.1989;74(11). VI. KotukhovYu.A. ListofvascularplantsofKazakhstanAltai. Botan. Researches ofSiberiaandKazakhstan.2005;11. VII. KotukhovYu. The current state of populations of rare and endangered plants in Eastern Kazakhstan. Almaty : AST, 2009. VIII. Kotukhov Yu.A., DanilovaA.N., AnufrievaO.A. Synopsisoftheonions (AlliumL.) oftheKazakhstanAltai, Sauro-ManrakandtheZaisandepression. BotanicalstudiesofSiberiaandKazakhstan. 2011;17 : 3-33. IX. Kotukhov, Yu.A., Baytulin, I.O. Rareandendangered, endemicandrelictelementsofthefloraofKazakhstanAltai. MaterialsoftheIntern. scientific-practical. conf. ‘Sustainablemanagementofprotectedareas’.Almaty : Ridder, 2010. X. Krasnoborov I.M. et al. The determinant of plants of the Republic of Altai. Novosibirsk : SB RAS, 2012. XI. Levichev I.G. On the species status of Gagea Rubicunda. Botanical Journal.1997;6:71-76. XII. Levichev I.G. A new species of the genus Gagea (Liliaceae). Botanical Journal. 2000;7 : 186-189. XIII. Levichev I.G., Jangb Chang-gee, Seung Hwan Ohc, Lazkovd G.A.A new species of genus GageaSalisb.(Liliaceae) from Kyrgyz Republic (Western Tian Shan, Chatkal Range, Sary-Chelek Nature Reserve). Journal of Asia-Pacific Biodiversity.2019 ; 12 : 341-343. XIV. Peterson A., Levichev I.G., Peterson J. Systematics of Gagea and Lloydia (Liliaceae) and infrageneric classification of Gagea based on molecular and morphological data. Molecular Phylogenetics and Evolution.2008 ; 46. XV. Peruzzi L., Peterson A., Tison J.-M., Peterson J. Phylogenetic relationships of GageaSalisb.(Liliaceae) in Italy, inferred from molecular and morphological data matrices. Plant Systematics and Evolution ; 2008 : 276. XVI. Rib R.D. Honey plants of Kazakhstan. Advertising Digest, 2013. XVII. Scherbakova L.I., Shirshikova N.A. Flora of medicinal plants in the vicinity of Ust-Kamenogorsk. Collection of materials of the scientific-practical conference ‘Unity of Education, Science and Innovation’. Ust-Kamenogorsk : EKSU, 2011. XVIII. syganovA.P. PrimrosesofEastKazakhstan. Ust-Kamenogorsk : EKSU, 2001. XIX. Tsyganov A.P. Flora and vegetation of the South Altai Tarbagatay. Berlin : LAP LAMBERT,2014. XX. Utyasheva, T.R., Berezovikov, N.N., Zinchenko, Yu.K. ProceedingsoftheMarkakolskStateNatureReserve. Ust-Kamenogorsk, 2009. XXI. Xinqi C, Turland NJ. Gagea. Flora of China.2000;24 : 117-121. XXII. Zarrei M., Zarre S., Wilkin P., Rix E.M. Systematic revision of the genus GageaSalisb. (Liliaceae) in Iran.BotJourn Linn Soc.2007;154. XXIII. Zarrei M., Wilkin P., Ingroille M.J., Chase M.W. A revised infrageneric classification for GageaSalisb. (Tulipeae ; Liliaceae) : insights from DNA sequence and morphological data.Phytotaxa.2011:5. View | Download INFLUENCE OF SUCCESSION CROPPING ON ECONOMIC EFFICIENCY OF NO-TILL CROP ROTATIONS Authors : Victor K. Dridiger,Roman S. Stukalov,Rasul G. Gadzhiumarov,Anastasiya A. Voropaeva,Viktoriay A. Kolomytseva, DOI : https://doi.org/10.26782/jmcms.spl.10/2020.06.00042 Abstract : This study was aimed at examining the influence of succession cropping on the economic efficiency of no-till field crop rotations on the black earth in the zone of unstable moistening of the Stavropol krai. A long-term stationary experiment was conducted to examine for the purpose nine field crop rotation patterns different in the number of fields (four to six), set of crops, and their succession in crop rotation. The respective shares of legumes, oilseeds, and cereals in the cropping pattern were 17 to 33, 17 to 40, and 50 to 67 %. It has been established that in case of no-till field crop cultivation the economic efficiency of plant production depends on the set of crops and their succession in rotation. The most economically efficient type of crop rotation is the soya-winter wheat-peas-winter wheat-sunflower-corn six-field rotation with two fields of legumes : in this rotation 1 ha of crop rotation area yields 3 850 grain units per ha at a grain unit prime cost of 5.46 roubles ; the plant production output return and profitability were 20,888 roubles per ha and 113 %, respectively. The high production profitabilities provided by the soya-winter wheat-sunflower four-field and the soya-winter-wheat-sunflower-corn-winter wheat five-field crop rotation are 108.7 and 106.2 %, respectively. The inclusion of winter wheat in crop rotation for two years in a row reduces the second winter wheat crop yield by 80 to 100 %, which means a certain reduction in the grain unit harvesting rate to 3.48-3.57 thousands per ha of rotation area and cuts the production profitability down to 84.4-92.3 %. This is why, no-till cropping should not include winter wheat for a second time Keywords : No-till technology,crop rotation,predecessor,yield,return,profitability, Refference : I Badakhova G. Kh. and Knutas A. V., Stavropol Krai : Modern Climate Conditions [Stavropol’skiykray : sovremennyyeklimaticheskiyeusloviya]. Stavropol : SUE Krai Communication Networks, 2007. II Cherkasov G. N. and Akimenko A. S. Scientific Basis of Modernization of Crop Rotations and Formation of Their Systems according to the Specializations of Farms in the Central Chernozem Region [Osnovy moderniz atsiisevooborotoviformirovaniyaikh sistem v sootvetstvii so spetsi-alizatsiyeykhozyaystvTsentral’nogoChernozem’ya]. Zemledelie. 2017 ; 4 : 3-5. III Decree 330 of July 6, 2017 the Ministry of Agriculture of Russia “On Approving Coefficients of Converting to Agricultural Crops to Grain Units [Ob utverzhdeniikoeffitsiyentovperevoda v zernovyyee dinitsysel’s kokhozyaystvennykhkul’tur]. IV Dridiger V. K., About Methods of Research of No-Till Technology [O metodikeissledovaniytekhnologii No-till]//Achievements of Science and Technology of AIC (Dostizheniyanaukiitekhniki APK). 2016 ; 30 (4) : 30-32. V Dridiger V. K. and Gadzhiumarov R. G. Growth, Development, and Productivity of Soya Beans Cultivated On No-Till Technology in the Zone of Unstable Moistening of Stavropol Region [Rost, razvitiyeiproduktivnost’ soiprivozdelyvaniipotekhnologii No-till v zone ne-ustoychivog ouvlazhneniyaStavropol’skogokraya]//Oil Crops RTBVNIIMK (Maslichnyyekul’turyNTBVNIIMK). 2018 ; 3 (175) : 52–57. VI Dridiger V. K., Godunova E. I., Eroshenko F. V., Stukalov R. S., Gadzhiumarov, R. G., Effekt of No-till Technology on erosion resistance, the population of earthworms and humus content in soil (Vliyaniyetekhnologii No-till naprotivoerozionnuyuustoychivost’, populyatsiyudozhdevykhcherveyisoderzhaniyegumusa v pochve)//Research Journal of Pharmaceutical, Biological and Chemical Sciences. 2018 ; 9 (2) : 766-770. VII Karabutov A. P., Solovichenko V. D., Nikitin V. V. et al., Reproduction of Soil Fertility, Productivity and Energy Efficiency of Crop Rotations [Vosproizvodstvoplodorodiyapochv, produktivnost’ ienergeticheskayaeffektivnost’ sevooborotov]. Zemledelie. 2019 ; 2 : 3-7. VIII Kulintsev V. V., Dridiger V. K., Godunova E. I., Kovtun V. I., Zhukova M. P., Effekt of No-till Technology on The Available Moisture Content and Soil Density in The Crop Rotation [Vliyaniyetekhnologii No-till nasoderzhaniyedostupnoyvlagiiplotnost’ pochvy v sevoob-orote]// Research Journal of Pharmaceutical, Biological and Chemical Sciences. 2017 ; 8 (6) : 795-99. IX Kulintsev V. V., Godunova E. I., Zhelnakova L. I. et al., Next-Gen Agriculture System for Stavropol Krai : Monograph [SistemazemledeliyanovogopokoleniyaStavropol’skogokraya : Monogtafiya]. Stavropol : AGRUS Publishers, Stavropol State Agrarian University, 2013. X Lessiter Frank, 29 reasons why many growers are harvesting higher no-till yields in their fields than some university scientists find in research plots//No-till Farmer. 2015 ; 44 (2) : 8. XI Rodionova O. A. Reproduction and Exchange-Distributive Relations in Farming Entities [Vosproizvodstvoiobmenno-raspredelitel’nyyeotnosheniya v sel’skokhozyaystvennykhorganizatsiyakh]//Economy, Labour, and Control in Agriculture (Ekonomika, trud, upravleniye v sel’skomkhozyaystve). 2010 ; 1 (2) : 24-27. XII Sandu I. S., Svobodin V. A., Nechaev V. I., Kosolapova M. V., and Fedorenko V. F., Agricultural Production Efficiency : Recommended Practices [Effektivnost’ sel’skokhozyaystvennogoproizvodstva (metodicheskiyerekomendatsii)]. Moscow : Rosinforagrotech, 2013. XIII Sotchenko V. S. Modern Corn Cultivation Technologies [Sovremennayatekhnologiyavozdelyvaniya]. Moscow : Rosagrokhim, 2009. View | Download DEVELOPMENT AND TESTING OF AUTONOMOUS PORTABLE SEISMOMETER DESIGNED FOR USE AT ULTRALOW TEMPERATURES IN ARCTIC ENVIRONMENT Authors : Mikhail A. Abaturov,Yuriy V. Sirotinskiy, DOI : https://doi.org/10.26782/jmcms.spl.10/2020.06.00043 Abstract : This paper is concerned with solving one of the issues of the general problem of designing geophysical equipment for the natural climatic environment of the Arctic. The relevance of the topic has to do with an increased global interest in this region. The paper is aimed at considering the basic principles of developing and the procedure of testing seismic instruments for use at ultralow climatic temperatures. In this paper the indicated issue is considered through the example of a seismic module designed for petroleum and gas exploration by passive seismoacoustic methods. The seismic module is a direct-burial portable unit of around 5 kg in weight, designed to continuously measure and record microseismic triaxial orthogonal (ZNE) noise in a range from 0.1 to 45 Hz during several days in autonomous mode. The functional chart of designing the seismic module was considered, and concrete conclusions were made for choosing the necessary components to meet the ultralow-temperature operational requirements. The conclusions made served for developing appropriate seismic module. In this case, the components and tools used included a SAFT MP 176065 xc low-temperature lithium cell, industrial-spec electronic component parts, a Zhaofeng Geophysical ZF-4.5 Chinese primary electrodynamic seismic sensor, housing seal parts made of frost-resistant silicone materials, and finely dispersed silica gel used as water-retaining sorbent to avoid condensation in the housing. The paper also describes a procedure of low-temperature collation tests at the lab using a New Brunswick Scientific freezing plant. The test results proved the operability of the developed equipment at ultralow temperatures down to -55°C. In addition, tests were conducted at low microseismic noises in the actual Arctic environment. The possibility to detect signals in a range from 1 to 10 Hz at the level close to the NLNM limit (the Peterson model) has been confirmed, which allows monitoring and exploring petroleum and gas deposits by passive methods. As revealed by this study, the suggested approaches are efficient in developing high-precision mobile seismic instruments for use at ultralow climatic temperatures. The solution of the considered instrumentation and methodical issues is of great practical significance as a constituent of the generic problem of Arctic exploration. Keywords : Seismic instrumentation,microseismic monitoring,Peterson model,geological exploration,temperature ratings,cooling test, Refference : I. AD797 : Ultralow Distortion, Ultralow Noise Op Amp, Analog Devices, Inc., Data Sheet (Rev. K). Analog Devices, Inc. URL : https://www.analog.com/media/en/technical-documentation/data-sheets/AD797.pdf(Date of access September 2, 2019). II. Agafonov, V. M., Egorov, I. V., and Shabalina, A. S. Operating Principles and Technical Characteristics of a Small-Sized Molecular–Electronic Seismic Sensor with Negative Feedback [Printsipyraboty I tekhnicheskiyekharakteristikimalogabaritnogomolekulyarno-elektronnogoseysmodatchika s otritsatel’noyobratnoysvyaz’yu]. SeysmicheskiyePribory (Seismic Instruments). 2014 ; 50 (1) : 1–8. DOI : 10.3103/S0747923914010022. III. Antonovskaya, G., Konechnaya, Ya.,Kremenetskaya, E., Asming, V., Kvaema, T., Schweitzer, J., Ringdal, F. Enhanced Earthquake Monitoring in the European Arctic. 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The Synthesis of Arctic Research (SOAR) project. Deep-Sea Research Part II. 152 : 1-7. DOI : 10.1016/j.dsr2.2018.05.013. XXV. MS-SPORT Viscous Silicone Lubricant with Fluoroplastic. ToR2257-010-45540231-2003. OOO VMPAUTO, URL : https://smazka.ru/attachments/get/469/ms-sport-tds.pdf(Date of access September 2, 2019). XXVI. New Brunswick™ Premium -86 °C Freezers. Operating manual. URL : https://www.eppendorf.com/product-media/doc/en/142770_Operating-Manual/New-Brunswick_Freezers_Operating-manual-86-C-Premium-Freezers.pdf(Date of access September 2, 2019). XXVII. New seismic digitizer/recorder for passive seismic monitoring applications. LandTech Enterprises. URL : http://www.landtechsa.com/Images/Instrument/SRi32L/SRi32L.pdf(Date of access September 2, 2019). XXVIII. Parker, T., Winberry, P., Huerta, A., Bainbridge, G., Devanney, P. Direct Burial Broadband Seismic Instrumentation for Polar Environments. Nanometrics Inc. 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URL : http://fciarctic.ru/index.php?page=ckpg (Date of access September 2, 2019). XXXV. Sobisevich, A. L.,Presnov, D. A.,Agafonov, V. M.,Sobisevich, L. E. Autonomous geohydroacoustic ice buoy of new generation [Vmorazhivayemyyavtonomnyygeogidroakusticheskiy buy novogopokoleniya]. Nauka I tekhnologicheskierazrabotki (Science and Technological Developments). 2018 ; 97 (1) : 25–34. [Special issue “Precise Geophysical Monitoring of Natural Hazards. Part 1. Instruments andTechnologies”]. DOI : 10.21455/ std2018.1-3. XXXVI. Zhukov, Y. V. Issues of resistance and reliability of electronic equipment products to the exposure factors [Voprosystoykosti i nadezhnostiizdeliyradioelektronnoytekhniki k vneshnimvozdeystvuyushchimfaktoram]. Provintsial’nyyenauchnyyezapiski (The journal Provincial scientific proceedings). 2019 ; 1 (9) : 118-124. View | Download COMPARATIVE ANALYSIS OF RESULTS OF TREATMENT OF PATIENTS WITH FOOT PATHOLOGY WHO UNDERWENT WEIL OPEN OSTEOTOMY BY CLASSICAL METHOD AND WITHOUT STEOSYNTHESIS Authors : Yuriy V. Lartsev,Dmitrii A. Rasputin,Sergey D. Zuev-Ratnikov,Pavel V.Ryzhov,Dmitry S. Kudashev,Anton A. Bogdanov, DOI : https://doi.org/10.26782/jmcms.spl.10/2020.06.00044 Abstract : The article considers the problem of surgical correction of the second metatarsal bone length. The article analyzes the results of treatment of patients with excess length of the second metatarsal bones that underwent osteotomy with and without osteosynthesis. The results of treatment of patients who underwent metatarsal shortening due to classical Weil-osteotomy with and without osteosynthesis were analyzed. The first group consisted of 34 patients. They underwent classical Weil osteotomy. The second group included 44 patients in whomosteotomy of the second metatarsal bone were not by the screw. When studying the results of the treatment in the immediate postoperative period, weeks 6, 12, slightly better results were observed in patients of the first group, while one year after surgical treatment the results in both groups were comparable. One year after surgical treatment, there were 2.9% (1 patient) of unsatisfactory results in the first group and 4.5% (2 patients) in the second group. Considering the comparability of the results of treatment in remote postoperative period, the choice of concrete method remains with the operating surgeon. Keywords : Flat feet,hallux valgus,corrective osteotomy,metatarsal bones, Refference : I. A novel modification of the Stainsby procedure : surgical technique and clinical outcome [Text] / E. Concannon, R. MacNiocaill, R. Flavin [et al.] // Foot Ankle Surg. – 2014. – Dec., Vol. 20(4). – P. 262–267. II. Accurate determination of relative metatarsal protrusion with a small intermetatarsal angle : a novel simplified method [Text] / L. Osher, M.M. Blazer, S. Buck [et al.] // J. Foot Ankle Surg. – 2014. – Sep.-Oct., Vol. 53(5). – P. 548–556. III. Argerakis, N.G. The radiographic effects of the scarf bunionectomy on rearfoot alignment [Text] / N.G. Argerakis, L.Jr. Weil, L.S. Sr. Weil // Foot Ankle Spec. – 2015. – Apr., Vol. 8(2). – P. 89–94. IV. Bauer, T. Percutaneous forefoot surgery [Text] / T. Bauer // Orthop. Traumatol. Surg. Res. – 2014. – Feb., Vol. 100(1 Suppl.). – P. S191–S204. V. Biomechanical Evaluation of Custom Foot Orthoses for Hallux Valgus Deformity [Text] // J. Foot Ankle Surg. – 2015. – Sep.-Oct., Vol.54(5). – P. 852–855. VI. Chopra, S. Characterization of gait in female patients with moderate to severe hallux valgus deformity [Text] / S. Chopra, K. Moerenhout, X. Crevoisier // Clin. Biomech. (Bristol, Avon). – 2015. – Jul., Vol. 30(6). – P. 629–635. VII. Computer assisted planning and custom-made surgical guide for malunited pronation deformity after first metatarsophalangeal joint arthrodesis in rheumatoid arthritis : a case report [Text] / M. Hirao, S. Ikemoto, H. Tsuboi [et al.] // Comput. Aided Surg. – 2014. – Vol. 19(1-3). – P. 13–19. VIII. Correlation between static radiographic measurements and intersegmental angular measurements during gait using a multisegment foot model [Text] / D.Y. Lee, S.G. Seo, E.J. Kim [et al.] // Foot Ankle Int. – 2015. – Jan., Vol.36(1). – P. 1–10. IX. Correlative study between length of first metatarsal and transfer metatarsalgia after osteotomy of first metatarsal [Text] : [Article in Chinese] / F.Q. Zhang, B.Y. Pei, S.T. Wei [et al.] // Zhonghua Yi XueZaZhi. – 2013. – Nov. 19, Vol. 93(43). – P. 3441–3444. X. Dave, M.H. Forefoot Deformity in Rheumatoid Arthritis : A Comparison of Shod and Unshod Populations [Text] / M.H. Dave, L.W. Mason, K. Hariharan // Foot Ankle Spec. – 2015. – Oct., Vol. 8(5). – P. 378–383. XI. Does arthrodesis of the first metatarsophalangeal joint correct the intermetatarsal M1M2 angle ? Analysis of a continuous series of 208 arthrodeses fixed with plates [Text] / F. Dalat, F. Cottalorda, M.H. Fessy [et al.] // Orthop. Traumatol. Surg. Res. – 2015. – Oct., Vol. 101(6). – P. 709–714. XII. Dynamic plantar pressure distribution after percutaneous hallux valgus correction using the Reverdin-Isham osteotomy [Text] : [Article in Spanish] / G. Rodríguez-Reyes, E. López-Gavito, A.I. Pérez-Sanpablo [et al.] // Rev. Invest. Clin. – 2014. – Jul., Vol. 66, Suppl. 1. – P. S79-S84. XIII. Efficacy of Bilateral Simultaneous Hallux Valgus Correction Compared to Unilateral [Text] / A.V. Boychenko, L.N. Solomin, S.G. Parfeyev [et al.] // Foot Ankle Int. – 2015. – Nov., Vol. 36(11). – P. 1339–1343. XIV. Endolog technique for correction of hallux valgus : a prospective study of 30 patients with 4-year follow-up [Text] / C. Biz, M. Corradin, I. Petretta [et al.] // J. OrthopSurg Res. – 2015. – Jul. 2, № 10. – P. 102. XV. First metatarsal proximal opening wedge osteotomy for correction of hallux valgus deformity : comparison of straight versus oblique osteotomy [Text] / S.H. Han, E.H. Park, J. Jo [et al.] // Yonsei Med. J. – 2015. – May, Vol. 56(3). – P. 744–752. XVI. Long-term outcome of joint-preserving surgery by combination metatarsal osteotomies for shortening for forefoot deformity in patients with rheumatoid arthritis [Text] / H. Niki, T. Hirano, Y. Akiyama [et al.] // Mod. Rheumatol. – 2015. – Sep., Vol. 25(5). – P. 683–638. XVII. Maceira, E. Transfer metatarsalgia post hallux valgus surgery [Text] / E. Maceira, M. Monteagudo // Foot Ankle Clin. – 2014. – Jun., Vol. 19(2). – P.285–307. XVIII. Nielson, D.L. Absorbable fixation in forefoot surgery : a viable alternative to metallic hardware [Text] / D.L. Nielson, N.J. Young, C.M. Zelen // Clin. Podiatr. Med. Surg. – 2013. – Jul., Vol. 30(3). – P. 283–293 XIX. Patient’s satisfaction after outpatient forefoot surgery : Study of 619 cases [Text] / A. Mouton, V. Le Strat, D. Medevielle [et al.] // Orthop. Traumatol. Surg. Res. – 2015. – Oct., Vol. 101(6 Suppl.). – P. S217–S220. XX. Preference of surgical procedure for the forefoot deformity in the rheumatoid arthritis patients–A prospective, randomized, internal controlled study [Text] / M. Tada, T. Koike, T. Okano [et al.] // Mod. Rheumatol. – 2015. – May., Vol. 25(3). – P.362–366. XXI. Redfern, D. Percutaneous Surgery of the Forefoot [Text] / D. Redfern, J. Vernois, B.P. Legré // Clin. Podiatr. Med. Surg. – 2015. – Jul., Vol. 32(3). – P. 291–332. XXII. Singh, D. Bullous pemphigoid after bilateral forefoot surgery [Text] / D. Singh, A. Swann // Foot Ankle Spec. – 2015. – Feb., Vol. 8(1). – P. 68–72. XXIII. Treatment of moderate hallux valgus by percutaneous, extra-articular reverse-L Chevron (PERC) osteotomy [Text] / J. Lucas y Hernandez, P. Golanó, S. Roshan-Zamir [et al.] // Bone Joint J. – 2016. – Mar., Vol. 98-B(3). – P. 365–373. XXIV. Weil, L.Jr. Scarf osteotomy for correction of hallux abducto valgus deformity [Text] / L.Jr. Weil, M. Bowen // Clin. Podiatr. Med. Surg. – 2014. – Apr., Vol.31(2). – P. 233–246. View | Download QUANTITATIVE ULTRASONOGRAPHY OF THE STOMACH AND SMALL INTESTINE IN HEALTHYDOGS Authors : Roman A. Tcygansky,Irina I. Nekrasova,Angelina N. Shulunova,Alexander I.Sidelnikov, DOI : https://doi.org/10.26782/jmcms.spl.10/2020.06.00045 Abstract : Purpose.To determine the quantitative echogenicity indicators (and their ratio) of the layers of stomach and small intestine wall in healthy dogs. Methods. A prospective 3-year study of 86 healthy dogs (aged 1-7 yrs) of different breeds and of both sexes. Echo homogeneity and echogenicity of the stomach and intestines wall were determined by the method of Silina, T.L., et al. (2010) in absolute values of average brightness levels of ultrasound image pixels using the 8-bit scale with 256 shades of gray. Results. Quantitative echogenicity indicators of the stomach and the small intestine wall in dogs were determined. Based on the numerical values characterizing echogenicity distribution in each layer of a separate structure of the digestive system, the coefficient of gastric echogenicity is determined as 1:2.4:1.1 (mucosa/submucosa/muscle layers, respectively), the coefficient of duodenum and jejunum echogenicity is determined as 1:3.5:2 and that of ileum is 1:1.8:1. Clinical significance. The echogenicity coefficient of the wall of the digestive system allows an objective assessment of the stomach and intestines wall and can serve as the basis for a quantitative assessment of echogenicity changes for various pathologies of the digestive system Keywords : Ultrasound (US),echogenicity,echogenicity coefficient,digestive system,dogs,stomach,intestines, Refference : I. Agut, A. Ultrasound examination of the small intestine in small animals // Veterinary focus. 2009.Vol. 19. No. 1. P. 20-29. II. Bull. 4.RF patent 2398513, IPC51A61B8 / 00 A61B8 / 14 (2006.01) A method for determining the homoechogeneity and the degree of echogenicity of an ultrasound image / T. Silina, S. S. Golubkov. – No. 2008149311/14 ; declared 12/16/2008 ; publ. 09/10/2010 III. Choi, M., Seo, M., Jung, J., Lee, K., Yoon, J., Chang, D., Park, RD. Evaluation of canine gastric motility with ultrasonography // J. of Veterinary Medical Science. – 2002. Vol. 64. – № 1. – P. 17-21. IV. Delaney, F., O’Brien, R.T., Waller, K.Ultrasound evaluation of small bowel thickness compared to weight in normal dogs // Veterinary Radiology and Ultrasound. 2003 Vol. 44, № 5. Р 577-580. V. Diana, A., Specchi, S., Toaldo, M.B., Chiocchetti, R., Laghi, A., Cipone, M. Contrast-enhanced ultrasonography of the small bowel in healthy cats // Veterinary Radiology and Ultrasound. – 2011. – Vol. 52, № 5. – Р. 555-559. VI. Garcia, D.A.A., Froes, T.R. Errors in abdominal ultrasonography in dogs and cats // J. of Small Animal Practice. – 2012. Vol. 53. – № 9. – P. 514-519. VII. Garcia, D.A.A., Froes, T.R. Importance of fasting in preparing dogs for abdominal ultrasound examination of specific organs // J. of Small Animal Practice. – 2014. Vol. 55. – № 12. – P. 630-634. VIII. Gaschen, L., Granger, L.A., Oubre, O., Shannon, D., Kearney, M., Gaschen, F. The effects of food intake and its fat composition on intestinal echogenicity in healthy dogs // Veterinary Radiology and Ultrasound. 2016. Vol. 57. № 5. P. 546-550 IX. Gaschen, L., Kircher, P., Stussi, A., Allenspach, K., Gaschen, F., Doherr, M., Grone, A. Comparison of ultrasonographic findings with clinical activity index (CIBDAI) and diagnosis in dogs with chronic enteropathies // Veterinary radiology and ultrasound. – 2008. – Vol. 49. – № 1. – Р. 56-64. X. Gil, E.M.U. Garcia, D.A.A. Froes, T.R. In utero development of the fetal intestine : Sonographic evaluation and correlation with gestational age and fetal maturity in dogs // Theriogenology. 2015. Vol. 84, №5. Р. 681-686. XI. Gladwin, N.E. Penninck, D.G., Webster, C.R.L. Ultrasonographic evaluation of the thickness of the wall layers in the intestinal tract of dogs // American Journal of Veterinary Research. 2014. Vol. 75, №4. Р. 349-353. XII. Gory, G., Rault, D.N., Gatel, L, Dally, C., Belli, P., Couturier, L., Cauvin, E. Ultrasonographic characteristics of the abdominal esophagus and cardia in dogs // Veterinary Radiology and Ultrasound. 2014. Vol. 55, № 5. P. 552-560. XIII. Günther, C.S. Lautenschläger, I.E., Scholz, V.B. Assessment of the inter- and intraobserver variability for sonographical measurement of intestinal wall thickness in dogs without gastrointestinal diseases | [Inter-und Intraobserver-Variabilitätbei der sonographischenBestimmung der Darmwanddicke von HundenohnegastrointestinaleErkrankungen] // Tierarztliche Praxis Ausgabe K : Kleintiere – Heimtiere. 2014. Vol. 42 №2. Р. 71-78. XIV. Hanazono, K., Fukumoto, S., Hirayama, K., Takashima, K., Yamane, Y., Natsuhori, M., Kadosawa, T., Uchide, T. Predicting Metastatic Potential of gastrointestinal stromal tumors in dog by ultrasonography // J. of Veterinary Medical Science. – 2012. Vol. 74. – № 11. – P. 1477-1482. XV. Heng, H.G., Lim, Ch.K., Miller, M.A., Broman, M.M.Prevalence and significance of an ultrasonographic colonic muscularishyperechoic band paralleling the serosal layer in dogs // Veterinary Radiology and Ultrasound. 2015. Vol. 56 № 6. P. 666-669. XVI. Ivančić, M., Mai, W. Qualitative and quantitative comparison of renal vs. hepatic ultrasonographic intensity in healthy dogs // Veterinary Radiology and Ultrasound. 2008. Vol. 49. № 4. Р. 368-373. XVII. Lamb, C.R., Mantis, P. Ultrasonographic features of intestinal intussusception in 10 dogs // J. of Small Animal Practice. – 2008. Vol. 39. – № 9. – P. 437-441. XVIII. Le Roux, A. B., Granger, L.A., Wakamatsu, N, Kearney, M.T., Gaschen, L.Ex vivo correlation of ultrasonographic small intestinal wall layering with histology in dogs // Veterinary Radiology and Ultrasound.2016. Vol. 57. № 5. P. 534-545. XIX. Nielsen, T. High-frequency ultrasound of Peyer’s patches in the small intestine of young cats / T. Nielsen [et al.] // Journal of Feline Medicine and Surgery. – 2015. – Vol. 18, № 4. – Р. 303-309. XX. PenninckD.G. Gastrointestinal tract. In Nyland T.G., Mattoon J.S. (eds) : Small Animal Diagnostic Ultrasound. Philadelphia : WB Saunders. 2002, 2nd ed. Р. 207-230. XXI. PenninckD.G. Gastrointestinal tract. In : PenninckD.G.,d´Anjou M.A. Atlas of Small Animal Ultrasonography. Blackwell Publishing, Iowa. 2008. Р. 281-318. XXII. Penninck, D.G., Nyland, T.G., Kerr, L.Y., Fisher, P.E. Ultrasonographic evaluation of gastrointestinal diseases in small animals // Veterinary Radiology. 1990. Vol. 31. №3. P. 134-141. XXIII. Penninck, D.G.,Webster, C.R.L.,Keating, J.H. The sonographic appearance of intestinal mucosal fibrosis in cats // Veterinary Radiology and Ultrasound. – 2010. – Vol. 51, № 4. – Р. 458-461. XXIV. Pollard, R.E.,Johnson, E.G., Pesavento, P.A., Baker, T.W., Cannon, A.B., Kass, P.H., Marks, S.L. Effects of corn oil administered orally on conspicuity of ultrasonographic small intestinal lesions in dogs with lymphangiectasia // Veterinary Radiology and Ultrasound. 2013. Vol. 54. № 4. P. 390-397. XXV. Rault, D.N., Besso, J.G., Boulouha, L., Begon, D., Ruel, Y. Significance of a common extended mucosal interface observed in transverse small intestine sonograms // Veterinary Radiology and Ultrasound. 2004. Vol. 45. №2. Р. 177-179. XXVI. Sutherland-Smith, J., Penninck, D.G., Keating, J.H., Webster, C.R.L. Ultrasonographic intestinal hyperechoic mucosal striations in dogs are associated with lacteal dilation // Veterinary Radiology and Ultrasound. – 2007. Vol. 48. – № 1. – P. 51-57. View | Download EVALUATION OF ADAPTIVE POTENTIAL IN MEDICAL STUDENTS IN THE CONTEXT OF SEASONAL DYNAMICS Authors : Larisa A. Merdenova,Elena A. Takoeva,Marina I. Nartikoeva,Victoria A. Belyayeva,Fatima S. Datieva,Larisa R. Datieva, DOI : https://doi.org/10.26782/jmcms.spl.10/2020.06.00046 Abstract : The aim of this work was to assess the functional reserves of the body to quantify individual health ; adaptation, psychophysiological characteristics of the health quality of medical students in different seasons of the year. When studying the temporal organization of physiological functions, the rhythm parameters of physiological functions were determined, followed by processing the results using the Cosinor Analysis program, which reveals rhythms with an unknown period for unequal observations, evaluates 5 parameters of sinusoidal rhythms (mesor, amplitude, acrophase, period, reliability). The essence of desynchronization is the mismatch of circadian rhythms among themselves or destruction of the rhythms architectonics (instability of acrophases or their disappearance). Desynchronization with respect to the rhythmic structure of the body is of a disregulatory nature, most pronounced in pathological desynchronization. High neurotism, increased anxiety reinforces the tendency to internal desynchronization, which increases with stress. During examination stress, students experience a decrease in the stability of the temporary organization of the biosystem and the tension of adaptive mechanisms develops, which affects attention, mental performance and the quality of adaptation to the educational process. Time is shortened and the amplitude of the “initial minute” decreases, personal and situational anxiety develops, and the level of psychophysiological adaptation decreases. The results of the work are priority because they can be used in assessing quality and level of health. Keywords : Desynchronosis,biorhythms,psycho-emotional stress,mesor,acrophase,amplitude,individual minute, Refference : I. Arendt, J., Middleton, B. Human seasonal and circadian studies in Antarctica (Halley, 75_S) – General and Comparative Endocrinology. 2017 : 250-259. (http://dx.doi.org/10.1016/j.ygcen.2017.05.010). II. BalandinYu.P. A brief methodological guide on the use of the agro-industrial complex “Health Sources” / Yu.P. Balandin, V.S. Generalov, V.F. Shishlov. Ryazan, 2007. III. Buslovskaya L.K. Adaptation reactions in students at exam stress/ L.K. Buslovskaya, Yu.P. Ryzhkova. Scientific bulletin of Belgorod State University. Series : Natural Sciences. 2011;17(21):46-52. IV. Chutko L. S. Sindromjemocionalnogovygoranija – Klinicheskie I psihologicheskieaspekty./ L.S Chutko. Moscow : MEDpress-inform, 2013. V. Eroshina K., Paul Wilkinson, Martin Mackey. The role of environmental and social factors in the occurrence of diseases of the respiratory tract in children of primary school age in Moscow. Medicine. 2013:57-71. VI. Fagrell B. “Microcirculation of the Skin”. The physiology and pharmacology of the microcirculation. 2013:423. VII. Gurova O.A. Change in blood microcirculation in students throughout the day. New research. 2013 ; 2 (35):66-71. VIII. Khetagurova L.G. – Stress/Ed. L.G. Khetagurov. Vladikavkaz : Project-Press Publishing House, 2010. IX. Khetagurova L.G., Urumova L.T. et al. Stress (chronomedical aspects). International Journal of Experimental Education 2010 ; 12 : 30-31. X. Khetagurova L.G., Salbiev K.D., Belyaev S.D., Datieva F.S., Kataeva M.R., Tagaeva I.R. Chronopathology (experimental and clinical aspects/ Ed. L.G. Khetagurov, K.D. Salbiev, S.D.Belyaev, F.S. Datiev, M.R. Kataev, I.R. Tagaev. Moscow : Science, 2004. XI. KlassinaS.Ya. Self-regulatory reactions in the microvasculature of the nail bed of fingers in person with psycho-emotional stress. Bulletin of new medical technologies, 2013 ; 2 (XX):408-412. XII. Kovtun O.P., Anufrieva E.V., Polushina L.G. Gender-age characteristics of the component composition of the body in overweight and obese schoolchildren. Medical Science and Education of the Urals. 2019 ; 3:139-145. XIII. Kuchieva M.B., Chaplygina E.V., Vartanova O.T., Aksenova O.A., Evtushenko A.V., Nor-Arevyan K.A., Elizarova E.S., Efremova E.N. A comparative analysis of the constitutional features of various generations of healthy young men and women in the Rostov Region. Modern problems of science and education. 2017 ; 5:50-59. XIV. Mathias Adamsson1, ThorbjörnLaike, Takeshi Morita – Annual variation in daily light expo-sure and circadian change of melatonin and cortisol consent rations at a northern latitude with large seasonal differences in photoperiod length – Journal of Physiological Anthropology. 2017 ; 36 : 6 – 15. XV. Merdenova L.A., Tagaeva I.R., Takoeva E.A. Features of the study of biological rhythms in children. The results of fundamental and applied research in the field of natural and technical sciences. Materials of the International Scientific and Practical Conference. Belgorod, 2017, pp. 119-123. XVI. Ogarysheva N.V. The dynamics of mental performance as a criterion for adapting to the teaching load. Bulletin of the Samara Scientific Center of the Russian Academy of Sciences. 2014;16:5 (1) : S.636-638. XVII. Pekmezovi T. Gene-environment interaction : A genetic-epidemiological approach. Journal of Medical Biochemistry. 2010;29:131-134. XVIII. Rapoport S.I., Chibisov S.M. Chronobiology and chronomedicine : history and prospects/Ed. S.M. Chibisov, S.I. Rapoport ,, M.L. Blagonravova. Chronobiology and Chronomedicine : Peoples’ Friendship University of Russia (RUDN) Press. Moscow, 2018. XIX. Roustit M., Cracowski J.L. “Non-invasive assessment of skin microvascular function in humans : an insight into methods” – Microcirculation 2012 ; 19 (1) : 47-64. XX. Rud V.O., FisunYu.O. – References of the circadian desinchronosis in students. Ukrainian Bulletin of Psychoneurology. 2010 ; 18(2) (63) : 74-77. XXI. Takoeva Z. A., Medoeva N. O., Berezova D. T., Merdenova L. A. et al. Long-term analysis of the results of chronomonitoring of the health of the population of North Ossetia ; Vladikavkaz Medical and Biological Bulletin. 2011 ; 12(12,19) : 32-38. XXII. Urumova L.T., Tagaeva I.R., Takoeva E.A., Datieva L.R. – The study of some health indicators of medical students in different periods of the year. Health and education in the XXI century. 2016 ; 18(4) : 94-97. XXIII. Westman J. – Complex diseases. In : Medical genetics for the modern clinician. USA : Lippincott Williams & ; Wilkins, 2006. XXIV. Yadrischenskaya T.V. Circadian biorhythms of students and their importance in educational activities. Problems of higher education. Pacific State University Press. 2016 ; 2:176-178. View | Download TRIADIC COMPARATIVE ANALYSIS Authors : Stanislav A.Kudzh,Victor Ya. Tsvetkov, DOI : https://doi.org/10.26782/jmcms.spl.10/2020.06.00047 Abstract : The present study of comparison methods based on the triadic model introduces the following concepts : the relation of comparability and the relation of comparison, and object comparison and attributive comparison. The difference between active and passive qualitative comparison is shown, two triadic models of passive and active comparison and models for comparing two and three objects are described. Triadic comparison models are proposed as an alternative to dyadic comparison models. Comparison allows finding the common and the different ; this approach is proposed for the analysis of the nomothetic and ideographic method of obtaining knowledge. The nomothetic method identifies and evaluates the general, while the ideographic method searches for unique in parameters and in combinations of parameters. Triadic comparison is used in systems and methods of argumentation, as well as in the analysis of consistency/inconsistency. Keywords : Comparative analysis,dyad,triad,triadic model,comparability relation,object comparison,attributive comparison,nomothetic method,ideographic method, Refference : I. AltafS., Aslam.M.Paired comparison analysis of the van Baarenmodel using Bayesian approach with noninformativeprior.Pakistan Journal of Statistics and Operation Research 8(2) (2012) 259{270. II. AmooreJ. E., VenstromD Correlations between stereochemical assessments and organoleptic analysis of odorous compounds. Olfaction and Taste (2016) 3{17. III. BarnesJ., KlingerR. Embedding projection for targeted cross-lingual sentiment : model comparisons and a real-world study. Journal of Artificial Intelligence Research 66 (2019) 691{742. doi.org/10.1613/jair.1.11561 IV. Castro-SchiloL., FerrerE.Comparison of nomothetic versus idiographic-oriented methods for making predictions about distal outcomes from time series data. Multivariate Behavioral Research 48(2) (2013) 175{207. V. De BonaG.et al. Classifying inconsistency measures using graphs. Journal of Artificial Intelligence Research 66 (2019) 937{987. VI. FideliR. La comparazione. Milano : Angeli, 1998. VII. GordonT. F., PrakkenH., WaltonD. The Carneades model of argument and burden of proof. Artificial Intelligence 10(15) (2007) 875{896. VIII. GrenzS.J. The social god and the relational self : A Triad theology of the imago Dei. Westminster : John Knox Press, 2001. IX. HermansH.J. M.On the integration of nomothetic and idiographic research methods in the study of personal meaning.Journal of Personality 56(4) (1988) 785{812. X. JamiesonK. G., NowakR. Active ranking using pairwise comparisons.Advances in Neural Information Processing Systems (2011) 2240{2248. XI. JongsmaC.Poythress’s triad logic : a review essay. Pro Rege 42(4) (2014) 6{15. XII. KärkkäinenV.M. Trinity and Religious Pluralism : The Doctrine of the Trinity in Christian Theology of Religions. London : Routledge, 2017. XIII. KudzhS. A., TsvetkovV.Ya. Triadic systems. Russian Technology Magazine 7(6) (2019) 74{882. XIV. NelsonK.E.Some observations from the perspective of the rare event cognitive comparison theory of language acquisition.Children’s Language 6 (1987) 289{331. XV. NiskanenA., WallnerJ., JärvisaloM.Synthesizing argumentation frameworks from examples. Journal of Artificial Intelligence Research 66 (2019) 503{554. XVI. PührerJ.Realizability of three-valued semantics for abstract dialectical frameworks.Artificial Intelligence 278 (2020) 103{198. XVII. SwansonG.Frameworks for comparative research : structural anthropology and the theory of action. In : Vallier, Ivan (Ed.). Comparative methods in sociology : essays on trends and applications.Berkeley : University of California Press, 1971 141{202. XVIII. TsvetkovV.Ya.Worldview model as the result of education.World Applied Sciences Journal 31(2) (2014) 211{215. XIX. TsvetkovV. Ya. Logical analysis and variable scales. Slavic Forum 4(22) (2018) 103{109. XX. Wang S. et al. Transit traffic analysis zone delineating method based on Thiessen polygon. Sustainability 6(4) (2014) 1821{1832. View | Download DEVELOPING TECHNOLOGY OF CREATING WEAR-RESISTANT CERAMIC COATING FOR ICE CYLINDER ». JOURNAL OF MECHANICS OF CONTINUA AND MATHEMATICAL SCIENCES spl10, n^o 1 (28 juin 2020). http://dx.doi.org/10.26782/jmcms.spl.10/2020.06.00048.

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