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Thèses sur le sujet « Saccharomyces cerevisiae, healthy aging »

Auteur : Grafiati

Publié le 9 mars 2023

Mis à jour le 31 juillet 2025

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1

RONZULLI, ROSSELLA. "The yeast Saccharomyces cerevisiae as a “road” from aging basic research to interventions for healthy aging." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2016. http://hdl.handle.net/10281/102384.

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Tutti gli organismi viventi col passare del tempo invecchiano, ossia vanno incontro ad un progressivo ed irreversibile declino funzionale/fisiologico, accompagnato da un aumentato rischio di contrarre malattie. Tra i diversi fattori coinvolti nell’invecchiamento, i nutrient-sensing pathway di TORC1/Sch9 e Ras/PKA e le Sirtuine, una famiglia di deacetilasi NAD+-dipendenti, svolgono un ruolo prioritario. Essi sono evolutivamente conservati dal lievito all’uomo, e risultano, inoltre, mediare alcuni degli effetti della Calorie Restriction (CR), un intervento che consiste nel limitare l’apporto di

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STAMERRA, GIULIA. "Nutraceutical approaches to promote healthy aging: the yeast Saccharomyces cerevisiae for the discovery of anti-aging interventions." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2019. http://hdl.handle.net/10281/241137.

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L’aumento dell’aspettativa di vita non è associato con un altrettanto aumento delle condizioni di salute nella popolazione anziana. Oggigiorno, un’ampia parte di popolazione al di sopra dei 65 anni soffre di molteplici malattie, molte delle quali debilitanti, come le malattie cardiovascolari, i tumori o i disordini neurodegenerativi. Questo aspetto ha aumentato l’interesse per le tematiche legate all’invecchiamento, enfatizzando l’importanza di ridurre il gap tra longevità salute durante l’invecchiamento. A questo proposito, gli sforzi di molte linee di ricerca sono focalizzati nel tentati

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Falcon, Alaric Antonio. "Building an episomal model of aging in saccharomyces cerevesiae." [Gainesville, Fla.] : University of Florida, 2004. http://wwwlib.umi.com/cr/ufl/fullcit?p3136937.

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Thesis (Ph.D.)--University of Florida, 2004.<br>Typescript. Title from title page of source document. Document formatted into pages; contains 117 pages. Includes Vita. Includes bibliographical references.

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Butler, Barbara L. "Separation of a brewing yeast strain of Saccharomyces cerevisiae based on cellular age." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=78334.

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In yeast, aging appears to be marked by a progressive impairment in cellular mechanisms, resulting in irreversible changes in physiology and morphology. To date, very little has been reported about the biochemical changes that occur in yeast as a function of individual cell aging. To investigate this further, six generations of a brewing yeast strain of Saccharomyces cerevisiae (NCYC 1239) were separated according to cellular age using continuous phased culturing and biotin-streptavidin magnetic cell sorting.<br>To obtain cells with no bud scars (virgin cells), a concentrated yeast slur

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Basa, Ranor C. B. "ERC Accumulation and Premature Aging: An Investigation of the Deletion of ASH1 in the Budding Yeast Saccharomyces cerevisiae." Scholarship @ Claremont, 2006. http://scholarship.claremont.edu/pomona_theses/119.

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This thesis concerns the asymmetric mechanism by which the "molecular aging clock" is reset in the budding yeast Saccharomyces cerevisiae, which is of great interest considering that many organisms' cells--including human stem cells--undergo this process. When yeast divides, it ages a generation, while daughter cells begin life at generation zero. One theory surrounding this process in yeast is the extrachromosomal rDNA circle (ERC) aging theory. ERCs are generated spontaneously in mother cells as they age, and thus accumulate exponentially in older cells. Daughter cells from young mothers ben

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Managbanag, JR. "Application of Shortest-Path Network Analysis to Identify Genes that Modulate Longevity in Saccharomyces cerevisiae." VCU Scholars Compass, 2008. http://scholarscompass.vcu.edu/etd/1613.

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Shortest-path network analysis was employed to identify novel genes that modulate longevity in the baker’s yeast Saccharomyces cerevisiae. Based upon a set of previously reported genes associated with increased life span, a shortest path network algorithm was applied to a pre-existing protein-protein interaction dataset in order to construct a shortest-path longevity network. To validate this network, the replicative aging potential of 88 single gene deletion strains corresponding to predicted components of the shortest path longevity network was determined. The 88 single-gene deletion str

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Shamalnasab, Mehrnaz. "Conserved Role of Acyl-CoA Binding Proteins in Life Span Regulation." Thesis, Lyon, École normale supérieure, 2012. http://www.theses.fr/2012ENSL0790.

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Depuis une vingtaine d’années, il est possible d’allonger la durée de vie génétiquement. Nombre d’études réalisées sur des espèces allant de la levure aux primates, ont permis d’identifier des cascades de signaux intracellulaires ayant un impact sur la longévité et la qualité du vieillissement. Il est important de noter que certaines de ces interventions réduisent considérablement l’incidence de cancers et de maladies liées au vieillissement chez les mammifères. Ceci témoigne des liens existant entre vieillissement et carcinogénèse et il probable que le développement de stratégies pharmacologi

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Anjos, Rafaela Maria Rios dos. "Mapeamento dos determinantes estruturais da proteína Rtg2p, envolvidos na sinalização retrógrada e no envelhecimento de Saccharomyces cerevisiae." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/87/87131/tde-26092016-110727/.

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Rtg2p é uma proteína que participa da sinalização retrógrada, uma via de comunicação da mitocôndria para o núcleo; também tem sido associada com a longevidade em S. cerevisiae. O objetivo deste trabalho foi identificar os determinantes estruturais de Rtg2p, envolvidos na sinalização retrógrada e no envelhecimento. Para isto foram produzidos treze mutantes pontuais a partir do desenho racional por decomposição de redes de correlação de aminoácidos (DRCN). Analisaram-se as cepas mutantes por ensaio de auxotrofia para glutamato, expressão do gene CIT2 e ensaio de longevidade replicativa. Em sua g

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Tahara, Erich Birelli. "Influência da restrição calórica no metabolismo bioenergético e estado redox de Saccharomyces cerevisiae e Kluyveromyces lactis." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-15052012-085726/.

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O envelhecimento envolve um progressivo declínio na eficiência metabólica dos sistemas biológicos ao longo do tempo. Embora não possa ser evitado, o envelhecimento pode ter seus fenótipos típicos mitigados em organismos submetidos à restrição calórica, um regime dietético que consiste em uma oferta diminuída de calorias. Ao longo do tempo, a levedura Saccharomyces cerevisiae mostrou-se um importante organismo modelo para o estudo de importantes marcas relacionadas ao envelhecimento, sobretudo por ser responsiva à restrição calórica. Através de uma abordagem do metabolismo energético e do estad

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Lesur, Kupin Isabelle. "Study of the transcriptome of the prematurely aging dna2-1 yeast mutant using a new system allowing comparative DNA microarray analysis." Bordeaux 1, 2005. http://www.theses.fr/2005BOR12976.

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Cette these decrit une methode originale de comparaison automatique d'experiences de transcriptome appliquee a la determination des causes du vieillissement de l'organisme eucaryote modele: Saccharomyces cerevisiae. Les experiences de transcriptome, qui peuvent etre realisees a l'aide de microarrays, permettent au biologiste d'etudier simultanement les variations globales d'expression de milliers de genes dans de nombreuses conditions experimentales. Ces experiences a grande echelle realisees a haut-debit generent une quantite importante de donnees. En consequence, les biologistes ont besoin d

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Lastauskienė, Eglė. "Ras/PKA signalinio kelio komponentų įtaka natūraliu terpės rūgštėjimu indukuojamai Saccharomyces cerevisiae ląstelių žūčiai." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2011. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2011~D_20110520_101720-00103.

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Nuolat kintanti aplinka yra pagrindinis veiksnys, kontroliuojantis mikroorganizmų augimą ir vystymąsi. Evoliucijos eigoje organizmuose išsivystė signalinės sistemos, gebančios sujungti aplinkos signalus su ląstelės transkripcijos, transliacijos ir kt. procesais. Viena iš tokių universalių signalinių sistemų yra Ras/PKA signalinis kelias. Ši sistema leidžia mielių ląstelėms reaguoti į aplinkoje esančius maisto medžiagų šaltinius ir įvairius stresinius veiksnius. Vienas iš pagrindinių aplinkos signalų, įtakojančių ląstelių fiziologiją, yra aplinkos pH. Mielių ląstelėse į aplinkos pH reaguoja Rim

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Paoletti, Camille. "Mécanismes de ségrégation asymétrique des agrégats protéiques liés à Hsp104 chez Saccharomyces cerevisiae." Thesis, Strasbourg, 2014. http://www.theses.fr/2014STRAJ089/document.

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La levure du boulanger a une durée de vie réplicative limitée : chaque cellule mère produit un nombre fini de filles avant de mourir. Cette entrée en sénescence est supposée notamment résulter de l’accumulation d’agrégats de protéines endommagées au sein de la cellule mère. La rétention des agrégats au sein des mères permettrait de produire des filles rajeunies. Cependant, ce mécanisme de ségrégation asymétrique reste controversé, en partie car il est complexe de suivre la dynamique des agrégats protéiques in vivo. Nous avons développé une méthodologie pour suivre la formation des agrégats pro

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Knieß, Robert A. [Verfasser], and Matthias Peter [Akademischer Betreuer] Mayer. "Analysis of replicative aging in Saccharomyces cerevisiae using fluorescence activated cell sorting / Robert André Knieß ; Betreuer: Matthias Peter Mayer." Heidelberg : Universitätsbibliothek Heidelberg, 2017. http://d-nb.info/1177688301/34.

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Knieß, Robert A. [Verfasser], and Matthias P. [Akademischer Betreuer] Mayer. "Analysis of replicative aging in Saccharomyces cerevisiae using fluorescence activated cell sorting / Robert André Knieß ; Betreuer: Matthias Peter Mayer." Heidelberg : Universitätsbibliothek Heidelberg, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:16-heidok-185766.

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Abdo, Hany. "Biodiversité fongique dans une nouvelle cuverie et dynamique des populations en cuverie (Saccharomyces cerevisiae) et en cave d'élevage (Brettanomyces bruxellensis)." Thesis, Bourgogne Franche-Comté, 2020. https://nuxeo.u-bourgogne.fr/nuxeo/site/esupversions/2d60b625-7462-4c12-a43b-dd6ccd94a8a9.

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La biodiversité fongique interspécifique (Illumina Mi-Seq) et la dynamique des espèces Saccharomyces cerevisiae et Brettanomyces bruxellensis ont été étudiées au sein d’une nouvelle cuverie et/ou dans 3 caves d’élevage, plus particulièrement sur le sol, les murs, le matériel vinaire et l’extérieur des fûts. Dans la nouvelle cuverie, un consortium fongique (levures et moisissures) de départ est déjà présent sur tous les environnments étudiés avant l’arrivée de la première vendange. Ce consortium est constitué de genres tels que Aureobasidium, Alternaria, Didymella et Filobasidium. Ces genres qu

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TAORMINA, Giusi. "Regolazione della longevità in Saccharomyces cerevisiae Ruolo di micro e macronutrienti nella modulazione dell'invecchiamento negli eucarioti." Doctoral thesis, Università degli Studi di Palermo, 2014. http://hdl.handle.net/10447/90864.

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In diversi organismi, dal lievito ai mammiferi, è stato osservato che la riduzione dell'introito calorico aumenta la sopravvivenza e protegge dall'insorgenza di numerose patologie associate all'età. Il meccanismo molecolare tramite cui questo effetto si realizza non è ancora chiaro. Questa ricerca mette in evidenza il ruolo di singoli nutrienti nella sensibilizzazione agli stress e nella promozione dell'invecchiamento, identifica in particolare tre specifici aminoacidi che agiscono da segnalatori pro-aging e descrive le vie molecolari attraverso cui tali molecole agiscono. Poiché i pathway di

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Barea, Fernanda. "Avaliação do tempo de vida cronológico em Saccharomyces cerevisiae em diferentes fontes de carbono associadas com o metabolismo e com os mecanismos de reparação de DNA." reponame:Repositório Institucional da UCS, 2008. https://repositorio.ucs.br/handle/11338/358.

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Uma dieta rica em carboidratos aparece como um dos poucos fatores ambientais capazes de interferir tanto na longevidade quanto no envelhecimento de um organismo. Neste sentido, a geração aumentada e o acúmulo dos AGEs (do inglês Advanced glycation end-products), formados por reações não enzimáticas entre os monossacarídeos glicose e frutose e/ou seus intermediários metabólicos com os ácidos nucleicos e grupos amina de proteínas, determinam a importância que estes produtos representam para a duração do ciclo de vida dos organismos. Os AGEs aparecem associados a uma série de patologias relaciona

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Wimble, Christopher. "Working Together: Using protein networks of bacterial species to compare essentiality, centrality, and conservation in Escherichia coli." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3878.

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Proteins in Escherichia coli were compared in terms of essentiality, centrality, and conservation. The hypotheses of this study are: for proteins in Escherichia coli, (1) there is a positive, measureable correlation between protein conservation and essentiality, (2) there is a positive relationship between conservation and degree centrality, and (3) essentiality and centrality also have a positive correlation. The third hypothesis was supported by a moderate correlation, the first with a weak correlation, and the second hypotheis was not supported. When proteins that did not map to orthologous

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Andrade, Restrepo Martín. "Mathematical modeling and evolutionary processes." Thesis, Sorbonne Paris Cité, 2019. http://www.theses.fr/2019USPCC021.

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La recherche présentée dans cette thèse concerne différents sujets dans le domaine de la biomathématique. J’aborde diverses questions en biologie (et liées aux systèmes complexes) avec des méthodes mathématiques et numériques. Ces questions sont les suivantes: (i) Les processus passifs sont-ils suffisants pour justifier la distribution asymétrique des protéines endommagées pendant et après la cytokinèse de la levure? (ii) Quels processus sont à l’origine des schémas complexes d’expansion de l’amyloïde bêta dans le cerveau des patients atteints de la maladie d’Alzheimer? (iii) Qu’y a-t-il derri

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Wang, Yu-Han, and 王煜涵. "Cellular Aging and Mitochondrial Dynamics in Saccharomyces cerevisiae." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/17840626509502703100.

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碩士<br>國立清華大學<br>生物科技研究所<br>99<br>粒線體融合與分裂的動態調控影響其於細胞中的功能，而在老化所導致的神經退化性疾病中，已經有很多研究顯示與粒線體的功能喪失及形態調控有直接關聯。故而本篇論文是從細胞老化的角度切入，釐清粒線體融合、分裂之動態平衡與老化的關係。在本篇研究中，採用了釀酒酵母(Saccharomyces cerevisiae)此種被廣泛利用的模式生物來作為本研究之對象，以修飾過的生物素(Biotin)標記在細胞表面，利用其與卵白素(Streptavidin)之高度親和力，再利用其與已鍵結上卵白素的微鐵珠 (micro-magnetic beads)作用，即可使用強力磁鐵達到分離已標記之原始細胞的目的。藉由此技術，可以將出芽生長分裂代數較多的酵母菌從培養的族群中分離出來，再利用已送入含有可標記粒線體綠螢光蛋白(Green-Fluorescent Protein)之質體，便可以觀察酵母菌因粒線體融合與分裂平衡的傾向所導致的不同粒線體形態。在細胞老化的層次上，可發現生長代數較多之野生種酵母菌顯現出較多粒線體碎裂的特徵，此現象在基因剔除粒線體分裂機制上必要的FIS1 以及DNM1 菌株中即不復出現；在mRNA 的表現量而言，FIS1 以及DNM1基因在分裂代數較多之酵母菌的樣品裡表現量也明顯提高，證實粒線體的動態調控機制參與了老化細胞裡粒線體分裂多於融

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Yang, Yen Kai, and 楊硯凱. "The Effect of DNA Damage Checkpoint on Replicative Aging in Saccharomyces cerevisiae." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/01288178756339398742.

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碩士<br>國立臺灣大學<br>食品科技研究所<br>102<br>Replication checkpoints serve as control mechanisms that ensure the fidelity of the replicating genome in eukaryotes. It was previously reported that a mouse model of checkpoint (ATR) deficiency exhibited replicative stress during embryogenesis, which resulted in premature aging. To further understand the role of the replication checkpoint in cellular aging, we took advantage of the ATR homologous gene MEC1 and its hypostatic gene RAD53 in yeast. We determined the replicative lifespans (RLS) of the hypomorphic mec1-100 and rad53-11 mutants; the life span of th

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Sing, Cierra Nicole. "Aging Actin' Up: A novel aging determinant regulates the actin cytoskeleton, nutrient sensing, and lifespan in Saccharomyces cerevisiae." Thesis, 2021. https://doi.org/10.7916/d8-s9z7-pb33.

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The aging process is unforgiving, targeting a decline in cellular function. Originally, the actin cytoskeleton has not been defined as a hallmark of aging biology, however, numerous studies provide evidence that actin cytoskeleton integrity is declining with age. Mammalian cells express an aged-linked decline in their actin dynamics, consequently defecting their migratory movements, immunological synapse formation, and phagocytosis. Overall, suggesting actin integrity is specifically targeted by aging. Despite the substantial evidence, the underlying mechanism remains elusive, however, current

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Lai, Man-Ning, and 賴曼寧. "Anti-skin aging effect of fermented product using Aspergillus oryzae and Saccharomyces cerevisiae." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/07181786700245312644.

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碩士<br>國立臺灣大學<br>食品科技研究所<br>102<br>Skin is the most visible organ in the aging process. The characteristics of skin aging include wrinkling, sallowness, laxity and dryness. Aging may result from both the passage of time (intrinsic aging) and from ultraviolet light exposure (extrinsic aging). Past research showed that sake (rice wine) has positive effect on skin, including prevention of UV damage, reduction of matrix metalloproteinase-1 (MMP-1) expression and increase of typeⅠprocollagen synthesis. However, rice wine production requires tedious procedures and longtime processing. In this study,

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Pernice, Wolfgang Maximilian. "Asymmetric Mitochondrial Inheritance and Retention in the Regulation of Aging in S. cerevisiae." Thesis, 2016. https://doi.org/10.7916/D8N58MP3.

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Both an intuitive observation and maybe the most mysterious process of biology, aging describes the progressive deterioration of cellular functions with time. Asymmetric cell divisions stand at the center of ability to reset age in offspring and for stem cells to self-renew. This requires the asymmetric segregation of age-determinants, many of which have been identified in the budding yeast Saccharomyces cerevisiae. We here use budding yeast to explore fundamental aspects underlying the asymmetric inheritance of mitochondria and the concurrent rejuvenation of daughter cells. We show that

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Chang, Jia-Ci, and 張家綺. "TOR1 Gene Regulates Genome Stability in Mismatch Repair Defected Cells during Chronological Aging in Saccharomyces cerevisiae." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/74447174459860328991.

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碩士<br>國立臺灣大學<br>食品科技研究所<br>102<br>Mismatch repair (MMR) is a DNA repair system which is critical for the maintenance of genome stability. Defects in mismatch repair have been linked to colorectal and sporadic cancers. Calorie restriction (CR) has been shown to extend life span and increases stress resistance via TOR/SCH9 and RAS signaling pathways in various organisms. We have found that CR containing 0.5% glucose compared to normal treatment (2.0% glucose) can extend life span and promote HOM3 gene stability in MMR-defected cells during aging process in yeast previously. Here, we demonstrate

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Teong, Xiao Tong, and 張曉彤. "Study of calorie restriction using RNA-sequencing profiling in mismatch repair defected cells during chronological aging in Saccharomyces cerevisiae." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/47461222425481751243.

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碩士<br>國立臺灣大學<br>食品科技研究所<br>103<br>Calorie restriction (CR) is able to reduce cancer progression and extend life span in various organisms. Age-related decline of DNA repair system such as mismatch repair (MMR) can reverse by CR. Defects in MMR have been linked to colorectal and sporadic cancers. Our previous results have demonstrated that CR can extend life span and maintain genome stability in MMR-defected cells during aging, but the mechanisms are poorly understood. Therefore, we suggest base excision repair (BER) which has been proven can be up-regulated by CR, is responsible to maintain ge

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Chan, Chia-Hsuan, and 詹佳璇. "Investigation of the anti-aging effect and mechanism of ethanol extract from Ganoderma colossum in Saccharomyces cerevisiae / Investigation of the phenotypic effects of cell wall protein Hsp150p in Taiwan clinical isolates of Saccharomyces cerevisiae." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/49331834200710563411.

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碩士<br>國立臺灣大學<br>醫學檢驗暨生物技術學研究所<br>102<br>Abstract – Part I There are two methods to access the lifespan of yeast. One is called replicative lifespan (RLS) defined by the number of daughter cells produced by single mother cell. The other method called chronological lifespan (CLS) defined by how long yeasts survived in liquid culture. Nowadays, it is proposed that the cellular accumulation of reactive oxygen species (ROS) might reduce the lifespan of organism. According to previous studies, under the treatment of small natural molecule like hesperidin, the lifespan of yeast was extended by r

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"The role of metal metabolism and heat shock protein genes on replicative lifespan of the budding yeast, Saccharomyces cerevisiae." Thesis, 2015. http://hdl.handle.net/10388/ETD-2015-12-2367.

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A variety of genes that influence aging have been identified in a broad selection of organisms including Saccharomyces cerevisiae (yeast), Caenorhabditis elegans (worms), Drosophila (fruit flies), Macaca Mulatta (rhesus monkeys), and even Homo sapiens. Many of these genes, such the TOR’s, FOXO’s, AKT’s, and S6K’s are conserved across different organisms. All of these genes participate in nutrient sensing networks. Other conserved genetic networks may similarly affect lifespan. In this thesis, I explored genes from an iron metabolism family and a heat shock protein (HSP) gene family that have b

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"The forkhead box transcription factors, FKH1 and FKH2, along with the Anaphase-Promoting Complex regulate Saccharomyces cerevisiae lifespan." Thesis, 2014. http://hdl.handle.net/10388/ETD-2014-06-1592.

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Forkhead box (Fox) transcription factors have a conserved function in regulating lifespan and onset of age related disease in organisms from worms to mammals. Key functions in this process are the regulation of the cell cycle, oxidative stress response, and apoptosis. A complex post-translational code from nutrient, growth factor, and stress induced signals regulates Fox activity, target specificity, stability, and subcellular localization; however, many of the Fox mechanisms and targets responsible for regulating lifespan remain elusive. The budding yeast, Saccharomyces cerevisiae, is a power

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Sharom, Jeffrey Roslan. "A Global Kinase and Phosphatase Interaction Network in the Budding Yeast Reveals Novel Effectors of the Target of Rapamycin (TOR) Pathway." Thesis, 2011. http://hdl.handle.net/1807/29864.

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In the budding yeast Saccharomyces cerevisiae, the evolutionarily conserved Target of Rapamycin (TOR) signaling network regulates cell growth in accordance with nutrient and stress conditions. In this work, I present evidence that the TOR complex 1 (TORC1)-interacting proteins Nnk1, Fmp48, Mks1, and Sch9 link TOR to various facets of nitrogen metabolism and mitochondrial function. The Nnk1 kinase controlled nitrogen catabolite repression-sensitive gene expression via Ure2 and Gln3, and physically interacted with the NAD+-linked glutamate dehydrogenase Gdh2 that catalyzes deamination of glutama

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