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Littérature scientifique sur le sujet « Salivary markers »

Auteur : Grafiati

Publié le 15 mars 2025

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Articles de revues sur le sujet "Salivary markers"

Kamodyová, Natália, Lenka Baňasová, Katarína Janšáková, Ivana Koborová, Ľubomíra Tóthová, Peter Stanko et Peter Celec. « Blood Contamination in Saliva : Impact on the Measurement of Salivary Oxidative Stress Markers ». Disease Markers 2015 (2015) : 1–10. http://dx.doi.org/10.1155/2015/479251.

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Salivary oxidative stress markers represent a promising tool for monitoring of oral diseases. Saliva can often be contaminated by blood, especially in patients with periodontitis. The aim of our study was to examine the impact of blood contamination on the measurement of salivary oxidative stress markers. Saliva samples were collected from 10 healthy volunteers and were artificially contaminated with blood (final concentration 0.001–10%). Next, saliva was collected from 12 gingivitis and 10 control patients before and after dental hygiene treatment. Markers of oxidative stress were measured in all collected saliva samples. Advanced oxidation protein products (AOPP), advanced glycation end products (AGEs), and antioxidant status were changed in 1% blood-contaminated saliva. Salivary AOPP were increased in control and patients after dental treatment (by 45.7% and 34.1%,p<0.01). Salivary AGEs were decreased in patients after microinjury (by 69.3%,p<0.001). Salivary antioxidant status markers were decreased in both control and patients after dental treatment (p<0.05andp<0.01). One % blood contamination biased concentrations of salivary oxidative stress markers. Saliva samples with 1% blood contamination are visibly discolored and can be excluded from analyses without any specific biochemic detection of blood constituents. Salivary markers of oxidative stress were significantly altered in blood-contaminated saliva in control and patients with gingivitis after dental hygiene treatment.

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Tóthová, L’ubomíra, Viera Celecová et Peter Celec. « Salivary Markers of Oxidative Stress and Their Relation to Periodontal and Dental Status in Children ». Disease Markers 34, n^o 1 (2013) : 9–15. http://dx.doi.org/10.1155/2013/591765.

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Background: Previous studies have shown that salivary thiobarbituric acid reactive substances are related to the periodontal status in adults. Such an analysis has not been done on children yet. The aim of our study was to analyze salivary markers of oxidative stress in relation to periodontal and dental status in children.Methods: The periodontal and dental status of 82 consecutive pediatric dental patients was assessed. The oral hygiene index (OHI), the papillary bleeding index (PBI) and the caries index (CI) were assessed as clinical parameters. Markers of oxidative stress and antioxidant status were measured in whole saliva samples.Results: Multivariate analysis of covariance showed that the variability of PBI explains 10.9% of the variance of salivary thiobarbituric acid reacting substances (TBARS). Advanced oxidation protein products (AOPP) were related to CI (eta 8.6%). Measures of antioxidant status (total antioxidant capacity and ferric reducing ability of saliva) were partially determined by OHI (13.6% and 7.2%) and PBI (16.9% and 7.9%).Conclusions: Antioxidant status in saliva is related to oral hygiene and periodontal status. Salivary TBARS are a potential sensitive marker of periodontitis in children, similarly to adults, at least on a population level. Salivary AOPP are related to caries. Potential diagnostic value of the analyzed markers should be analyzed in further interventional studies.

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Bakhsh, Abdulaziz, Noor Al-Abdulla, Francesco Mannocci, Marwa Allihaibi, David Moyes, Gordon Proctor et Sadia Ambreen Niazi. « The Impact of Apical Periodontitis and Endodontic Treatment on Salivary Inflammatory Biomarkers : A Longitudinal Study ». Applied Sciences 13, n^o 6 (20 mars 2023) : 3952. http://dx.doi.org/10.3390/app13063952.

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This study aimed to assess the effect of apical periodontitis and its treatment on the profile of salivary inflammatory markers and to investigate its correlation with serum inflammatory markers. Saliva samples were collected from 115 recruited participants. Patients were reviewed after 1 and 2 years following treatment. Saliva samples were analysed using Multiplex microbead immunoassay for identifying the inflammatory biomarkers’ profile. Biomarker levels were compared against healthy controls at baseline. Longitudinal comparison of those markers was further analysed for the review appointments and correlated with the size of the periapical radiolucency, treatment outcome and serum inflammatory biomarker levels. The salivary cytokines, matrix metalloproteinases (MMPs) and vascular adhesion molecules were higher at the review appointments. Pre-operative salivary levels of high-sensitivity C-reactive protein (hs-CRP) were significantly higher in the treatment group than in the control group (p < 0.001). At 1 year, hs-CRP was decreased than baseline. While, in 2 years, fibroblast growth factor (FGF)-23 was significantly lower compared to baseline levels (p = 0.005). Furthermore, the post-operative size of radiolucency was significantly correlated with the levels of several markers. When correlating the salivary levels of biomarkers with the serum levels, a significant correlation was seen in FGF-23 (p = 0.04) at baseline; in intercellular adhesion molecule (ICAM)-1 (p = 0.02) at 1 year post-treatment; and in TNF-α, ICAM-1 and E-Selectin at 2 years post-treatment (p = 0.046; p = 0.033; p = 0.019, respectively). Therefore, his study suggests that higher salivary cytokines, MMPs and vascular adhesion molecules at the post-treatment reviews are related to periapical bone healing and remodelling, whereas salivary FGF-23 and hs-CRP could be prognostic biomarkers. Correlation of some salivary with serum biomarkers suggests that saliva sampling could be a feasible non-invasive option for the measurement of inflammatory marker levels; however, further longitudinal studies are required.

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Poposki, Bojan, Kiro Ivanovski, Renata Stefanova, Katarina Dirjanska, Irena Rambabova-Bushljetik, Vangel Ristovski et Nada Risteska. « Salivary Markers in Patients with Chronic Kidney Disease ». PRILOZI 44, n^o 2 (1 juillet 2023) : 139–47. http://dx.doi.org/10.2478/prilozi-2023-0033.

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Abstract Aim of the study: To determine the possibility of using saliva as a diagnostic and prognostic tool for screening and monitoring kidney function. Methods: This study included 32 patients with different stages of chronic kidney disease (CKD) and 20 healthy examinees for the control group. Saliva was collected using the spitting method, and on the same day blood was also drawn from the examinees to determine serum concentrations of urea and creatinine. The salivary values of uric acid, urea, creatinine and albumin were determined with a spectrophotometer, as well as the serum concentrations of urea and creatinine. Results: Our results showed a statistically significant positive correlation between salivary and serum levels of urea and creatinine in patients with CKD (Pearson’s correlation coefficient for urea was r =0.6527, p = 0.000, while for creatinine it was r = 0.5486, p = 0.001). We detected a statistically significant positive correlation between the salivary levels of urea and the clinical stage of CKD (r = 0.4667, p = 0.007). We did not register a significant correlation between the salivary levels of creatinine and the clinical stage of CKD (r = 0.1643, p = 0.369). Conclusion : Salivary urea is a valid marker for determining kidney function and a potential salivary marker for screening and monitoring kidney function. Salivary creatinine can be used as a qualitative marker, only indicating the existence of a disease.

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Risteska, Nada, Bojan Poposki, Kiro Ivanovski, Katarina Dirjanska, Stevica Ristoska et Mirko Saveski. « Diagnostic and Prognostic Markers of Periodontal Disease ». PRILOZI 42, n^o 3 (1 décembre 2021) : 89–95. http://dx.doi.org/10.2478/prilozi-2021-0039.

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Abstract Aim of the study: The aim of this study is to determine the values of salivary enzyme biomarkers (alkaline phosphatase – ALP, aspartate aminotransferase – AST and lactate dehydrogenase – LDH) in subjects with healthy and diseased periodontium and to investigate the possibility of using these salivary enzymes as diagnostic and prognostic markers. Methods: We collected saliva with the spitting method from all examinees in the morning, using the recommendations provided by Navazesh. The values of the enzymes in saliva were determined spectro-photometrically, with the following methods: ALP-IFCC, AST-IFCC, LDH-PYRUVATE. IGI Silness-Löe was used to determine the presence of gingival inflammation, and to determine the presence of clinically manifest periodontitis, we determined the clinical loss of periodontal attachment with a graduated periodontal probe. For statistical purposes, we used the method of ANOVA Chi Square and Student’s t-test. Results: The difference in the average salivary AST and LDH values between the first and the second group, as well between the first and third group is statistically significant (p < 0.000). The difference in the average salivary AST and LDH values between the examinees with gingivitis and the examinees with clinically manifest periodontal disease is statistically insignificant (p < 0.485101 for AST, p < 0.816665 for LDH). The difference in the average salivary levels of ALP between the three groups is statistically significant (p < 0.000). Conclusion: The salivary levels of AST, LDH, and ALP can be used as diagnostic markers, while ALP can also be used as a prognostic marker for periodontal disease.

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Waszkiewicz, Napoleon, Katarzyna Pawłowicz, Natalia Okuniewska, Mikołaj Kwiatkowski, Daniel Zalewski, Karolina Wilczyńska, Agata Szulc et al. « Salivary Carbohydrate-Deficient Transferrin in Alcohol- and Nicotine-Dependent Males ». Journal of Clinical Medicine 9, n^o 12 (15 décembre 2020) : 4054. http://dx.doi.org/10.3390/jcm9124054.

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Serum carbohydrate-deficient transferrin (CDT), an 80 kDa glycoprotein, is one of the most commonly employed biomarkers to detect alcohol dependence. Some salivary glycoproteins such as α-amylase, clusterin, haptoglobin, light/heavy-chain immunoglobulin, and transferrin, which alter glycosylation in alcohol-dependent persons, have been suggested to be potential alcohol markers. However, their identification is based on indirect analysis of lectin glycosidic bonds and molecular weight. We investigated the CDT content in the saliva of alcohol- and nicotine-dependent men. The CDT concentration (ng/mL, ng/mg protein) was determined by an Enzyme-Linked Immunosorbent Assay (ELISA) commercial kit in 55 men: 20 healthy social drinkers (C), 10 chronic cigarette smokers (S), 10 alcohol-dependent non-smokers (A), and 15 alcohol-dependent smokers (AS). Surprisingly, there were no differences in the concentrations of CDT between the studied groups. Salivary pH was the lowest in the AS and the highest in the A group. Therefore, salivary CDT cannot be used as an alcohol dependence marker as measured by ELISA. We suggest that direct identification of glycoproteins is necessary to search for potential salivary alcohol biomarkers. Molecules smaller than 40 kDa, which easily translocate from blood to the saliva, might be preferred as salivary alcohol markers.

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Srinivasan, Mythily, Corinne Blackburn, Mohamed Mohamed, A. V. Sivagami et Janice Blum. « Literature–Based Discovery of Salivary Biomarkers for Type 2 Diabetes Mellitus ». Biomarker Insights 10 (janvier 2015) : BMI.S22177. http://dx.doi.org/10.4137/bmi.s22177.

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The alarming increase in type 2 diabetes mellitus (T2DM) underscores the need for efficient screening and preventive strategies. Select protein biomarker profiles emerge over time during T2DM development. Periodic evaluation of these markers will increase the predictive ability of diabetes risk scores. Noninvasive methods for frequent measurements of biomarkers are increasingly being investigated. Application of salivary diagnostics has gained importance with the establishment of significant similarities between the salivary and serum proteomes. The objective of this study is to identify T2DM–specific salivary biomarkers by literature–based discovery. A serial interrogation of the PubMed database was performed using MeSH terms of specific T2DM pathological processes in primary and secondary iterations to compile cohorts of T2DM–specific serum markers. Subsequent search consisted of mining for the identified serum markers in human saliva. More than 60% of T2DM–associated serum proteins have been measured in saliva. Nearly half of these proteins have been reported in diabetic saliva. Measurements of salivary lipids and oxidative stress markers that can exhibit correlated saliva plasma ratio could constitute reliable factors for T2DM risk assessment. We conclude that a high percentage of T2DM–associated serum proteins can be measured in saliva, which offers an attractive and economical strategy for T2DM screening.

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Nijakowski, Kacper, et Anna Surdacka. « Salivary Biomarkers for Diagnosis of Inflammatory Bowel Diseases : A Systematic Review ». International Journal of Molecular Sciences 21, n^o 20 (10 octobre 2020) : 7477. http://dx.doi.org/10.3390/ijms21207477.

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Saliva as a biological fluid has a remarkable potential in the non-invasive diagnostics of several systemic disorders. Inflammatory bowel diseases are chronic inflammatory disorders of the gastrointestinal tract. This systematic review was designed to answer the question “Are salivary biomarkers reliable for the diagnosis of inflammatory bowel diseases?”. Following the inclusion and exclusion criteria, eleven studies were included (according to PRISMA statement guidelines). Due to their heterogeneity, the potential salivary markers for IBD were divided into four groups: oxidative status markers, inflammatory cytokines, microRNAs and other biomarkers. Active CD patients manifest decreased activity of antioxidants (e.g., glutathione, catalase) and increased lipid peroxidation. Therefore, malondialdehyde seems to be a good diagnostic marker of CD. Moreover, elevated concentrations of proinflammatory cytokines (such as interleukin 1β, interleukin 6 or tumour necrosis factor α) are associated with the activity of IBD. Additionaly, selected miRNAs are altered in saliva (overexpressed miR-101 in CD; overexpressed miR-21, miR-31, miR-142-3p and underexpressed miR-142-5p in UC). Among other salivary biomarkers, exosomal PSMA7, α-amylase and calprotectin are detected. In conclusion, saliva contains several biomarkers which can be used credibly for the early diagnosis and regular monitoring of IBD. However, further investigations are necessary to validate these findings, as well as to identify new reliable salivary biomarkers.

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Podzimek, Stepan, Lucie Vondrackova, Jana Duskova, Tatjana Janatova et Zdenek Broukal. « Salivary Markers for Periodontal and General Diseases ». Disease Markers 2016 (2016) : 1–8. http://dx.doi.org/10.1155/2016/9179632.

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The determination of biomarkers in saliva is becoming an important part of laboratory diagnostics and the prediction of not only periodontal, but also other tissue and organ diseases. Biomarkers in saliva (e.g., enzymes, protein markers, or oxidative stress markers) can be used for activity determination and for periodontal disease prognosis. Saliva also contains many markers which can predict the risk of certain diseases (e.g., diabetes mellitus, cardiovascular, oncology, endocrinology, and psychiatric diseases). The study of salivary components proteomics clearly shows the relationship of periodontal diseases and diseases of distant systems, organs, or tissues.

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I. Abdulla, Hajer, Marwan S. Al-Nimer et Ali I. Al-Jumaily. « Interpretation of Oral Involvement in Patients with Sjögren's Syndrome by Using Salivary Markers ». Tikrit Journal for Dental Sciences 2, n^o 2 (21 janvier 2024) : 89–95. http://dx.doi.org/10.25130/tjds.2.2.1.

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Sjögren's syndrome (SS) is a chronic inflammatory disorder of the salivary and lacrimal glands that leads to functional impairment. Hypof unction of salivary glands is the main cause of oral pathological changes and is associated with alterations in the constituents of the saliva. This study aimed to test the hypothesis that proteomic approaches markers (notably peptides) are involved in the oral manifestations observed in Sjögren's syndrome (SS). A total number of 71 participants were admitted in the study; 21 of them have Sjögren's syndrome (Group I), 43 non- Sjögren's syndrome cases refer red or attended the dental clinic seeking for certain management (Group II) and 7 apparent healthy subjects without dental problems (Group III). Stimulated saliva was collected from each patients and participants for biochemical analysis including assessment of salivary protein and peptides. Salivary flow rate was significantly (p<0.01) reduced in SS patients by 33.4% and 24.1% of corresponding Group II and Group III respectively. The salivary protein concentrations (total albumin and peptides) pe r milliliter saliva fluid were increased in SS patients. Saliva peptides (2.09±1.01 mg/ml) level was significantly (p<0.05) hi gher than Group II (1.708±0.649 mg/ml) and Group III (1.339±0.517 mg/ml). Hypofunction of saliv ary glands in SS is associated with significant changes in the saliva constituents particularly the peptides.

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Thèses sur le sujet "Salivary markers"

Schmalz, Gerhard, Simin Li, Ralph Burkhardt, Sven Rinke, Felix Krause, Rainer Haak et Dirk Ziebolz. « MicroRNAs as salivary markers for periodontal diseases ». Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-206460.

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The aim of this review is to discuss current findings regarding the roles of miRNAs in periodontal diseases and the potential use of saliva as a diagnostic medium for corresponding miRNA investigations. For periodontal disease, investigations have been restricted to tissue samples and five miRNAs, that is, miR-142-3p, miR-146a, miR-155, miR-203, and miR-223, were repeatedly validated in vivo and in vitro by different validation methods. Particularly noticeable are the small sample sizes, different internal controls, and different case definitions of periodontitis in in vivo studies. Beside of that, the validated miRNAs are associated with inflammation and therefore with various diseases. Furthermore, several studies successfully explored the use of salivary miRNA species for the diagnosis of oral cancer. Different cancer types were investigated and heterogeneous methodology was used; moreover, no overlap of resultswas found. In conclusion, fivemiRNAs have consistently been reported for periodontitis; however, their disease specificity, detectability, and expression in saliva and their importance as noninvasive markers are questionable. In principle, a salivary miRNA diagnostic method seems feasible.However, standardized criteria and protocols for preanalytics, measurements, and analysis should be established to obtain comparable results across different studies.

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Coelho, Bertha Andrade [UNESP]. « Impacto do Mindfulness em mulheres submetidas a biópsia de mama : avaliação de parâmetros quantitativos e qualitativos dos marcadores de estresse ». Universidade Estadual Paulista (UNESP), 2018. http://hdl.handle.net/11449/153762.

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Introdução: Anualmente milhões de mulheres em todo o mundo são rastreadas para câncer de mama, sendo que algumas delas serão submetidas a procedimentos adicionais, entre eles a biópsia mamária. A biópsia de fragmento (core biopsy) guiada por ultrassonografia é um método minimamente invasivo para o diagnóstico de lesões mamárias suspeitas, e possui inúmeras vantagens quando comparada às biópsias cirúrgicas. A core biopsy é um procedimento ambulatorial no qual raramente é necessário o uso de medicações analgésicas após o procedimento. No entanto, qualquer procedimento invasivo, por menor que seja, vem acompanhado de experiências de ansiedade, dor e medo do desconhecido. A Medicina Anti-Estresse entende que os pensamentos, sentimentos, níveis de ansiedade e capacidade de lidar com eventos estressores podem afetar a saúde e a percepção de saúde. Programas de Medicina Anti Estresse reduzem o estresse e auxiliam os praticantes a terem atitudes positivas em seu cotidiano. O objetivo deste estudo controlado e randomizado foi avaliar o impacto das intervenções baseadas em Mindfulness (MBIs) em parâmetros quantitativos e qualitativos de estresse em pacientes submetidas a biópsias de mama guiadas por imagem. Métodos: Após assinarem o consentimento informado, 82 mulheres com indicação de biópsia de mama guiada por imagem foram randomizadas em dois grupos: grupo MBI ou grupo controle de cuidados padrão. Na semana anterior à biópsia, minutos antes na sala de espera e durante o procedimento, o grupo MBI foi exposto a meditações guiadas por áudio e músicas relaxantes e o grupo controle recebeu suporte da equipe de biópsia por meio de diálogo. As participantes preencheram questionários que avaliam depressão, ansiedade e estresse (DASS-21), dados demográficos e histórico médico, além de terem avaliado sua experiência de dor por meio de uma Escala Visual Analógica de Dor (EVA) e tiveram sua pressão arterial sistólica e diastólica, temperatura inicial e final, frequência cardíaca, saturação de oxigênio e cortisol salivar medidos. Resultados: A participação no grupo de intervenção foi associada a níveis reduzidos de estresse, pressão arterial, frequência cardíaca e saturação de oxigênio em comparação com a participação no grupo de cuidados padrão (valores de P < 0,05). Não houve diferença em relação aos níveis salivares de cortisol, temperatura periférica e percepção de dor entre os dois grupos estudados. Conclusão: Os resultados indicam que intervenções extremamente breves em Mindfuness são viáveis e aceitáveis, sugerindo que programas baseados em atenção plena podem ser benéficos para reduzir o desconforto em situações de estresse agudo.
Introduction: Each year worldwide millions of women are screened for breast cancer and some of them will undergo additional investigations, including breast biopsy. Ultrasound guided core needle biopsy is a minimally invasive method for the diagnosis of suspected mammary lesions and has many advantages when compared to surgical biopsies. Core biopsy is an outpatient procedure and analgesic medication is rarely necessary after tissue removal. Nevertheless, any invasive procedure, however small it may be, is accompanied by experiences of anxiety, pain and fear of the unknown. Anti Stress Medicine recognizes that thoughts, feelings, levels of anxiety, and ability to cope with stressful events can affect health and health perception. Anti-Stress Medicine programs reduce stress and help practitioners to have positive attitudes in their daily lives. The purpose of this randomized controlled trial was to evaluate the impact of Mindfulness-based interventions (MBIs) on quantitative and qualitative stress parameters on patients undergoing imaging-guided breast biopsies. Methods: After giving informed consent, 82 women that needed percutaneous imaging-guided breast biopsy were randomized into two groups: MBI group or standard care control group. One week before the biopsy procedure, minutes prior to the biopsy procedure on the waiting room and during the biopsy procedure, the MBI group was exposed to audio guided meditations and relaxing music and the standard care control group received supportive dialogue from the biopsy team. Participants completed questionnaires measuring depression, anxiety and stress (DASS-21), demographics, and medical history, evaluated their pain experience through a Visual Analogue Scale for Pain (VAS) and had their systolic and diastolic blood pressure, initial and final temperate, heart rate, oxygen saturation and cortisol salivary measured. Results: Participation in the mindfulness intervention group was associated with reduced levels of perceived stress, blood pressure, heart rate and oxygen saturation compared to participation in the standard care group (P values < 0.05). No difference was observed regarding salivary cortisol levels, peripheral temperature and pain perception between the two studied groups. Conclusion: Results indicate that an extremely brief mindfulness intervention is a feasible and acceptable intervention, suggesting that Mindfulness-based programs may be beneficial to reduce discomfort in acutely stressful settings.

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Coelho, Bertha Andrade. « Impacto do Mindfulness em mulheres submetidas a biópsia de mama avaliação de parâmetros quantitativos e qualitativos dos marcadores de estresse / ». Botucatu, 2018. http://hdl.handle.net/11449/153762.

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Orientador: Agnaldo Lopes da Silva Filho
Resumo: Introdução: Anualmente milhões de mulheres em todo o mundo são rastreadas para câncer de mama, sendo que algumas delas serão submetidas a procedimentos adicionais, entre eles a biópsia mamária. A biópsia de fragmento (core biopsy) guiada por ultrassonografia é um método minimamente invasivo para o diagnóstico de lesões mamárias suspeitas, e possui inúmeras vantagens quando comparada às biópsias cirúrgicas. A core biopsy é um procedimento ambulatorial no qual raramente é necessário o uso de medicações analgésicas após o procedimento. No entanto, qualquer procedimento invasivo, por menor que seja, vem acompanhado de experiências de ansiedade, dor e medo do desconhecido. A Medicina Anti-Estresse entende que os pensamentos, sentimentos, níveis de ansiedade e capacidade de lidar com eventos estressores podem afetar a saúde e a percepção de saúde. Programas de Medicina Anti Estresse reduzem o estresse e auxiliam os praticantes a terem atitudes positivas em seu cotidiano. O objetivo deste estudo controlado e randomizado foi avaliar o impacto das intervenções baseadas em Mindfulness (MBIs) em parâmetros quantitativos e qualitativos de estresse em pacientes submetidas a biópsias de mama guiadas por imagem. Métodos: Após assinarem o consentimento informado, 82 mulheres com indicação de biópsia de mama guiada por imagem foram randomizadas em dois grupos: grupo MBI ou grupo controle de cuidados padrão. Na semana anterior à biópsia, minutos antes na sala de espera e durante o procedimento... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: Introduction: Each year worldwide millions of women are screened for breast cancer and some of them will undergo additional investigations, including breast biopsy. Ultrasound guided core needle biopsy is a minimally invasive method for the diagnosis of suspected mammary lesions and has many advantages when compared to surgical biopsies. Core biopsy is an outpatient procedure and analgesic medication is rarely necessary after tissue removal. Nevertheless, any invasive procedure, however small it may be, is accompanied by experiences of anxiety, pain and fear of the unknown. Anti Stress Medicine recognizes that thoughts, feelings, levels of anxiety, and ability to cope with stressful events can affect health and health perception. Anti-Stress Medicine programs reduce stress and help practitioners to have positive attitudes in their daily lives. The purpose of this randomized controlled trial was to evaluate the impact of Mindfulness-based interventions (MBIs) on quantitative and qualitative stress parameters on patients undergoing imaging-guided breast biopsies. Methods: After giving informed consent, 82 women that needed percutaneous imaging-guided breast biopsy were randomized into two groups: MBI group or standard care control group. One week before the biopsy procedure, minutes prior to the biopsy procedure on the waiting room and during the biopsy procedure, the MBI group was exposed to audio guided meditations and relaxing music and the standard care control group receiv... (Complete abstract click electronic access below)
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Lam, Julia, et Sandip Vekariya. « The relation between salivary suPAR and arthritis in the temporomandibular joint ». Thesis, Malmö högskola, Odontologiska fakulteten (OD), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-19710.

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Syfte: Att utreda sambandet mellan den lösliga formen av urokinas-receptorn (suPAR) i saliv hos patienter med artrit i käkleden (A-TMJ) och friska kontroller, för att skapa en grund för vidare forskning av suPAR som prediktor för inflammationsgraden i käkleden hos patienter med A-TMJ.Material och metod: En fall-kontrollstudie utfördes med 6 kontroller (medelåldern 31±11år) och 5 patienter med A-TMJ (medelåldern 24±5år). Undersökningen bestod av salivprov, registrering av blödning vid sondering (BoP), blodprovstagning, och undersökning av tuggsystemet där antalet smärtsamma käkledsrörelser (PM) mättes. Sist samlades käkledvätska in. Halten suPAR analyserades i saliv, plasma och käkledsvätska. Resultat: En signifikant skillnad mellan suPAR i saliv kunde ej påvisas (A-TMJ 4,4±3,91ng/ml, kontroller 4,96±4,80ng/ml), emellertid hade patienter en signifikant högre halt av suPAR i plasma (A-TMJ 2,71±0,62ng/ml, kontroller: 1,86±0,35ng/ml, P=0,017). Halten av suPAR i käkledsvätska mättes till 1,57±1,50ng/ml hos patienter men kunde inte detekteras hos kontroller. BoP mättes till 16±9% hos patienter och 14±7% hos kontroller, och median(IQR) för PM var 3(1) i höger käkled och 0(3) i vänster käkled hos patienter. Slutsatser: (i) Ingen slutsats kan dras gällande sambandet mellan suPAR i saliv och A-TMJ, men (ii) patienter med A-TMJ har till viss mån en högre smärta i käkleden vid käkledsrörelse medan deras koncentration av suPAR i plasma är högre jämfört med friska kontroller. Det verkar som (iii) BoP skulle kunna vara kopplat till suPAR i saliv. Resultat från denna studie bör tolkas med försiktighet på grund av litet stickprov, fortsatt forskning behövs för att klargöra sambandet mellan suPAR i saliv och A-TMJ.
Aims: To investigate the levels of soluble urokinase plasminogen activator receptor (suPAR) in saliva between patients with arthritis in the temporomandibular joint (A-TMJ) and healthy controls to create a foundation for further research of the potential predictive value of suPAR in patients with A-TMJ.Materials and method: A case- control study was conducted, 6 controls (mean age 31±11years) and 5 patients with A-TMJ (mean age 24±5years) enrolled in the study. Saliva, blood, synovial fluid (SF) were sampled, and the masticatory system was examined according to DC/TMD, and bleeding on probing (BoP) was assessed, as was painful mandibular movement (PM). The level of suPAR was analyzed in saliva, plasma and SF.Results: Level of salivary suPAR did not differ significantly between A-TMJ patients and healthy controls (P > 0.05). Patients had a significantly higher level of suPAR in plasma than controls (A-TMJ 2.71±0.62ng/mL, controls: 1.86±0.35ng/mL, P=0.017). suPAR level in SF was measured to 1.57±1.50ng/mL in A-TMJ patients and not detected in controls. BoP was 16±9% in patients and 14±7% in controls, and median(IQR) of PM was 3(1) in the right TMJ and 0(3) in the left in patients.Conclusions: (i) No conclusion can be drawn regarding suPAR in saliva and A-TMJ, but (ii) to some degree A-TMJ patients have higher PM meanwhile their plasma concentration of suPAR is higher than controls. A trend that (iii) higher BoP is connected with higher suPAR in saliva could be distinguished. Results must be interpreted with caution due to small study sample, more research is required to further elucidate the association between suPAR in saliva and A-TMJ.

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Dimitriou, Lygeri. « The effects of physical training and competition on selected haematological, salivary and psychological markers of immune and health status ». Thesis, Brunel University, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.488620.

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The thesis examines acute and chronic effects of physical training or competition on the kinetics of selected clinical and psychological markers, together with associations between some of these markers and other variables in three exercising groups.

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Ford, Julia Ann. « The use of salivary immunoglobulin-A as a marker exercise-induced immunomodulation ». Thesis, University of Chichester, 1999. http://eprints.chi.ac.uk/940/.

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Attempts have been made to account for the increased propensity of upper respiratory tract infections (URTI) in regularly training individuals, by focusing on the effect of exercise on the primary mucosal immunoglobulin secretory immunoglobulin A (sIgA). However, the pathophysiological significance of observed changes in sIgA levels remains unclear, as indeed does the existence of increased URTI in athletes. The aim of this work was to examine the use of sIgA as a marker of exercise-induced immunomodulation and its possible role in protection against URTI. Before these questions could be addressed the optimum method for saliva collection, and the ideal terms for expression of sIgA levels were investigated. Experimental data advocate the use of the passive dribbling method above the use of salivettes. Salivettes were found to result in an underestimation of both saliva flow rate and protein concentrations as a consequence of limited absorption (3 ± 1ml) and variable retention of the sample (49.1 ± 24.9%). Secretory IgA levels are commonly expressed in terms of secretion rate which is the product of saliva flow rate and sIgA concentration. Examination of the relative contribution of these two factors to secretion rate revealed that exercise-induced changes in saliva flow rate (-51 %) matched the changes in secretion rate (-51 %), whereas changes in sIgA concentrations (+4%) did not. It was concluded that changes in saliva flow rates have an important role with the occurrence of symptoms associated with URTI whether induced by infective or inflammatory factors. Epidemiological data from others on the incidence of symptoms associated with URTI in marathon runners have provided evidence on the incidence of URTI in athletes. However here, reported symptoms associated with URTI were most common during the race suggesting that an infective agent was not involved. Examination of the effect of marathon running revealed a non-significant decrease in saliva flow rate (-27.7 ± 15.8%). A final study investigated the effect of increased ambient temperature, and the possibility of fluid replacement as a intervention strategy against exercise-induced decreases in saliva flow rate. This study revealed that exercise reduced saliva flow rate exercise in the heat exacerbated this and that fluid replacement tempered the exercise-induced decrease. Changes in saliva flow rate were found to be associated with changes in plasma volume. The overall conclusions of this thesis are that innate defence mechanisms such as saliva have a role to play in conferring defence against potential pathogens, and therefore warrant further investigation. It appears from data presented in this thesis that saliva flow rate is affected by exercise, perhaps to a greater extent than sIgA concentration. Changes in saliva flow rate with exercise may have a role to play in the purported increased incidence of URTI reported by athletes, and fluid replacement may provide an effective strategy against this exercise-induced decrease.

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Sundelin, Kaarina. « Head and Neck Cancer : Factors Affecting Tumour Growth ». Doctoral thesis, Linköping : Univ, 2007. http://www.bibl.liu.se/liupubl/disp/disp2007/med1032s.pdf.

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Oliver, Samuel J. « Fluid and energy deficits : Hydration markers, saliva immunoglobulin A and endurance performance ». Thesis, Bangor University, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.505956.

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Marteus, Helena. « Oropharyngeal origin of markers in exhaled breath / ». Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-274-8/.

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Ohashi, Junko. « The Effects of Coaching on Salivary Cortisol Stress Marker in Mothers with Young Children, A Randomized Controlled Trial ». 京都大学 (Kyoto University), 2015. http://hdl.handle.net/2433/199217.

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Livres sur le sujet "Salivary markers"

1954-, Wong David, dir. Salivary diagnostics. Ames, Iowa : Wiley-Blackwell, 2008.

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Asli, Beau. Bacterial biomarkers in exhaled breath condensate and saliva. 2010.

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Chickanna, Rudrakshi, et Dhoom Singh Mehta. A comparative evaluation of Scatter Factor levels in GCF and saliva : Scatter Factor-A Marker. LAP Lambert Academic Publishing, 2012.

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Chapitres de livres sur le sujet "Salivary markers"

Seifert, Gerhard, et Jorg Caselitz. « Epithelial Salivary Gland Tumors : Tumor Markers ». Dans Progress in Surgical Pathology, 157–87. Berlin, Heidelberg : Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-662-12814-5_8.

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Pérez-Sayáns, Mario, Cintia M. Chamorro-Petronacci, Pilar Gándara-Vila et Alejandro I. Lorenzo-Pouso. « Salivary Markers in Systemic and Oral Cancer ». Dans Saliva in Health and Disease, 247–80. Cham : Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-37681-9_12.

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Muñoz-Prieto, Alberto, Eduardo Pons-Fuster et Pia López-Jornet. « Salivary Markers in Inflammatory and Autoimmune Diseases ». Dans Saliva in Health and Disease, 177–92. Cham : Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-37681-9_9.

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Ali, Syed Amaan, Safia Habib, Asif Ali, Moinuddin et Ekramul Haque. « Role of Salivary Markers for Diagnosis of Systemic Diseases ». Dans Toxicology and Human Health, 159–78. Singapore : Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-99-2193-5_7.

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Tuffaha, Muin S. A., Hans Guski et Glen Kristiansen. « Markers and Immunoprofile of Tumors of the Oral Cavity and Salivary Gland Tumors ». Dans Immunohistochemistry in Tumor Diagnostics, 43–47. Cham : Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-53577-7_6.

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Tuffaha, Muin S. A., Hans Guski et Glen Kristiansen. « Markers and Immunoprofile of Tumors of the Oral Cavity, Oropharynx and Salivary Glands ». Dans Immunohistochemistry in Tumor Diagnostics, 57–66. Cham : Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-45024-2_6.

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Robert-Mercier, Tiphaine, Monique Dehoux, Dan Longrois et Jean Guglielminotti. « Salivary Amylase as a Preoperative Marker of Anxiety in Perioperative Medicine ». Dans Biomarkers in Disease : Methods, Discoveries and Applications, 291–311. Dordrecht : Springer Netherlands, 2015. http://dx.doi.org/10.1007/978-94-007-7696-8_31.

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Bosch, Jos A. « The Use of Saliva Markers in Psychobiology : Mechanisms and Methods ». Dans Monographs in Oral Science, 99–108. Basel : S. KARGER AG, 2014. http://dx.doi.org/10.1159/000358864.

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Iwasaki, Laura R. « Markers of paradental tissue remodeling in the gingival crevicular fluid and saliva of orthodontic patients ». Dans Biological mechanisms of tooth movement, 138–44. Chichester, UK : John Wiley & Sons, Ltd, 2015. http://dx.doi.org/10.1002/9781118916148.ch10.

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Bentham Science Publisher, Bentham Science Publisher. « Biological Markers and Salivary Cortisol ». Dans The Role of Saliva Cortisol Measurement in Health and Disease, 87–115. BENTHAM SCIENCE PUBLISHERS, 2012. http://dx.doi.org/10.2174/978160805342111201010087.

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Actes de conférences sur le sujet "Salivary markers"

Bel'skaya, L. « PREDICTIVE SIGNIFICANCE OF BIOCHEMICAL MARKERS OF SALIVA IN PATIENTS WITH LUNG CANCER COMBINED WITH COPD ». Dans XIV International Scientific Conference "System Analysis in Medicine". Far Eastern Scientific Center of Physiology and Pathology of Respiration, 2020. http://dx.doi.org/10.12737/conferencearticle_5fe01d9c2a59e1.13232371.

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A complex of salivary biochemical parameters, which have prognostic value in lung cancer, was revealed. Therefore, for the group of patients without COPD, these indicators include imidazole compounds and LDH, with mild COPD - only imidazole compounds, with moderate COPD - pH and LDH. This is the first time that such prognostic results were obtained using saliva.

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Schubert, Adrian D., Evgeny Izumchenko, Piotr T. Wysocki, David Sidransky et Mariana Brait. « Abstract 734 : Improved detection of salivary glands’ RNA markers in saliva samples ». Dans Proceedings : AACR Annual Meeting 2017 ; April 1-5, 2017 ; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-734.

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Larsen, Melinda, Riffard Jean-Gilles, David Soscia, Sharon Sequeira, Michael Melfi, Anand Gadre et James Castracane. « Development of Nanofiber Scaffolds for Engineering an Artificial Salivary Gland ». Dans ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. ASMEDC, 2010. http://dx.doi.org/10.1115/nemb2010-13372.

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There is currently a significant clinical need for artificial salivary glands as a therapeutic option for patients suffering from xerostomia. To achieve unidirectional fluid secretion, the epithelial acinar cells must establish and maintain polarity by partitioning the plasma membrane into distinct apical and basolateral membrane surfaces to achieve unidirectional fluid secretion. Establishment and maintenance of epithelial acinar cell polarity has been difficult to achieve in vitro, and yet is critical saliva secretion in an engineered salivary gland. Physical properties of the scaffold provided to epithelial cells will likely influence their ability to differentiate and achieve apical-basal polarity. We have engineered nanofiber matrices using the biocompatible polymer, PLGA (poly-L-lactic-co-glycolic acid) having differing topology and organization and documented the structure of these scaffolds using SEM. We evaluated the effects of several factors on epithelial cell attachment, self-organization, and apico-basal polarity on the scaffolds using confocal microscopy to examine expression and organization of apical tight junction proteins, ZO-1 and claudins, and basal markers, such as integrin α6 and the ECM protein fibronectin. The surface of the nanofiber matrix was functionalized with chemically-linked ligands to further optimize apical-basal polarity. These studies will identify an optimal scaffold for future use in an engineered functional salivary gland construct.

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Volf, Petr. « Sand fly salivary proteins as markers of host exposure to leishmaniases vectors ». Dans 2016 International Congress of Entomology. Entomological Society of America, 2016. http://dx.doi.org/10.1603/ice.2016.93269.

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Little, Frederic F., Diana M. Delgado, Nataliya Ryzhenko, Frank G. Oppenheim, Timothy M. Blicharz et David R. Walt. « Salivary Inflammatory Mediator Profiling And Correlation To Clinical Disease Markers In Adult Asthma ». Dans American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a4450.

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Milic, V., G. Radunovic, J. Marinkovic et N. Damjanov. « SAT0461 Ultrasonography of salivary glands in primary sjogren’s syndrome and association with disease activity, serological markers and biopsy of minor salivary glands ». Dans Annual European Congress of Rheumatology, EULAR 2018, Amsterdam, 13–16 June 2018. BMJ Publishing Group Ltd and European League Against Rheumatism, 2018. http://dx.doi.org/10.1136/annrheumdis-2018-eular.5165.

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Angelova, Sirma. « Clinical Manifestation of Caries in Association with Salivary Markers in Children with Nephrotic Syndrome ». Dans The 6th Human and Social Sciences at the Common Conference. Publishing Society, 2018. http://dx.doi.org/10.18638/hassacc.2018.6.1.269.

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Hsueh, Pei Chun, et Chih Ching Wu. « Abstract 1148 : Salivary auto-antibodies as diagnostic markers of oral cavity squamous cell carcinoma ». Dans Proceedings : AACR Annual Meeting 2020 ; April 27-28, 2020 and June 22-24, 2020 ; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-1148.

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Klimanov, Igor A., S. K. Soodaeva, E. V. Tush, N. I. Kubysheva, M. N. Izvolenskaya, T. I. Eliseeva, T. I. Kolegova et al. « Relationship between salivary markers of oxidative stress (OS) and different levels of control of bronchial asthma (BA) ». Dans ERS International Congress 2019 abstracts. European Respiratory Society, 2019. http://dx.doi.org/10.1183/13993003.congress-2019.pa1706.

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Gottehrer, Neil, et Jack Martin. « Abstract CT318 : Evaluation of salivary transcriptome markers for early detection of squamous cell cancer in a prospective blinded trial ». Dans Proceedings : AACR 106th Annual Meeting 2015 ; April 18-22, 2015 ; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-ct318.

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Rapports d'organisations sur le sujet "Salivary markers"

Michelmore, Richard, Eviatar Nevo, Abraham Korol et Tzion Fahima. Genetic Diversity at Resistance Gene Clusters in Wild Populations of Lactuca. United States Department of Agriculture, février 2000. http://dx.doi.org/10.32747/2000.7573075.bard.

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Genetic resistance is often the least expensive, most effective, and ecologically-sound method of disease control. It is becoming apparent that plant genomes contain large numbers of disease resistance genes. However, the numbers of different resistance specificities within a genepool and the genetic mechanisms generating diversity are poorly understood. Our objectives were to characterize diversity in clusters of resistance genes in wild progenitors of cultivated lettuce in Israel and California in comparison to diversity within cultivated lettuce, and to determine the extent of gene flow, recombination, and genetic instability in generating variation within clusters of resistance genes. Genetic diversity of resistance genes was analyzed in wild and cultivated germplasm using molecular markers derived from lettuce resistance gene sequences of the NBS-LRR type that mapped to the major cluster if resistance genes in lettuce (Sicard et al. 1999). Three molecular markers, one microsatellite marker and two SCAR markers that amplified LRR- encoding regions, were developed from sequences of resistance gene homologs at the Dm3 cluster (RGC2s) in lettuce. Variation for these markers was assessed in germplasm including 74 genotypes of cultivated lettuce, L. saliva and 71 accessions of the three wild Lactuca spp., L. serriola, L. saligna and L. virosa that represent the major species in the sexually accessible genepool for lettuce. Diversity was also studied within and between natural populations of L. serriola from Israel and California. Large numbers of haplotypes were detected indicating the presence of numerous resistance genes in wild species. We documented a variety of genetic events occurring at clusters of resistance genes for the second objective (Sicard et al., 1999; Woo el al., in prep; Kuang et al., in prepb). The diversity of resistance genes in haplotypes provided evidence for gene duplication and unequal crossing over during the evolution of this cluster of resistance genes. Comparison of nine resistance genes in cv. Diana identified 22 gene conversion and five intergenic recombinations. We cloned and sequenced a 700 bp region from the middle of RGC2 genes from six genotypes, two each from L. saliva, L. serriola, and L. saligna . We have identified over 60 unique RGC2 sequences. Phylogenetic analysis surprisingly demonstrated much greater similarity between than within genotypes. This led to the realization that resistance genes are evolving much slower than had previously been assumed and to a new model as to how resistance genes are evolving (Michelmore and Meyers, 1998). The genetic structure of L. serriola was studied using 319 AFLP markers (Kuang et al., in prepa). Forty-one populations from Turkey, Armenia, Israel, and California as well as seven European countries were examined. AFLP marker data showed that the Turkish and Armenian populations were the most polymorphic populations and the European populations were the least. The Davis, CA population, a recent post-Columbian colonization, showed medium genetic diversity and was genetically close to the Turkish populations. Our results suggest that Turkey - Armenia may be the center of origin and diversity of L. serriola and may therefore have the greatest diversity of resistance genes. Our characterization of the diversity of resistance genes and the genetic mechanisms generating it will allow informed exploration, in situ and ex situ conservation, and utilization of germplasm resources for disease control. The results of this project provide the basis for our future research work, which will lead to a detailed understanding of the evolution of resistance genes in plants.

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Ullman, Diane, James Moyer, Benjamin Raccah, Abed Gera, Meir Klein et Jacob Cohen. Tospoviruses Infecting Bulb Crops : Evolution, Diversity, Vector Specificity and Control. United States Department of Agriculture, septembre 2002. http://dx.doi.org/10.32747/2002.7695847.bard.

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Objectives. The overall goal of the proposed research was to develop a mechanistic understanding of tospovirus evolution, diversity and vector specificity that could be applied to development of novel methods for limiting virus establishment and spread. Our specific objectives were: 1) To characterize newly intercepted tospoviruses in onion, Hippeastrum and other bulb crops and compare them with the known tomato spotted wilt virus (TSWV) and its isolates; 2) To characterize intra- and interspecific variation in the virus transmission by thrips of the new and distinct tospoviruses. and, 3) To determine the basis of vector specificity using biological, cellular and molecular approaches. Background. New tospoviruses infecting bulb crops were detected in Israel and the US in the mid-90s. Their plant host ranges and relationships with thrips vectors showed they differed from the type member of the Tospovirus genus, tomato spotted wilt virus (TSWV). Outbreaks of these new viruses caused serious crop losses in both countries, and in agricultural and ornamental crops elsewhere. In the realm of plant infecting viruses, the tospoviruses (genus: Tospovirus , family: Bunyaviridae ) are among the most aggressive emerging viruses. Tospoviruses are transmitted by several species of thrips in a persistent, propagative fashion and the relationships between the viruses and their thrips vectors are often specific. With the emergence of new tospoviruses, new thrips vector/tospovirus relationships have also arisen and vector specificities have changed. There is known specificity between thrips vector species and particular tospoviruses, although the cellular and molecular bases for this specificity have been elusive. Major conclusions, solutions and achievements. We demonstrated that a new tospovirus, iris yellow spot virus (IYSV) caused "straw bleaching" in onion (Allium cepa) and lisianthus necrosis in lisianthus (Eustoma russellianum). Characterization of virus isolates revealed genetic diversity among US, Brazilian, Dutch and Israeli isolates. IYSV was not seed transmitted, and in Israel, was not located in bulbs of infected plants. In the US, infected plants were generated from infected bulbs. The relationship between IYSV and Thrips tabaci was shown to be specific. Frankliniella occidentalis, the primary vector of many other tospoviruses, did not transmit IYSV isolates in Israel or the US. Furthermore, 1': tabaci populations varied in their transmission ability. Transmission was correlated to IYSV presence in thrips salivary glands. In Israel, surveys in onion fields revealed that the onion thrips, Thrips tabaci Lindeman was the predominant species and that its incidence was strongly related to that of IYSV infection. In contrast, in the U.S., T. tabaci and F. occidentalis were present in high numbers during the times sampled. In Israel, insecticides reduced onion thrips population and caused a significant yield increase. In the US, a genetic marker system that differentiates non-thrips transmissible isolates from thrips transmissible isolate demonstrated the importance of the M RNA to thrips transmission of tospoviruses. In addition, a symbiotic Erwinia was discovered in thrips and was shown to cause significant artifacts in certain types of virus binding experiments. Implications, scientific and agricultural. Rapid emergence of distinct tospoviruses and new vector relationships is profoundly important to global agriculture. We advanced the understanding of IYSV in bulb crops and its relationships with thrips vector species. The knowledge gained provided growers with new strategies for control and new tools for studying the importance of particular viral proteins in thrips specificity and transmission efficiency.

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