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Littérature scientifique sur le sujet « Screening, Signalling »

Auteur : Grafiati

Publié le 9 mars 2023

Mis à jour le 31 juillet 2025

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Articles de revues sur le sujet "Screening, Signalling"

Jeong-Yoo Kim. "Signalling and Screening of Harsh Religious Norms." Journal of Social Science 41, no. 3 (2015): 103–16. http://dx.doi.org/10.15820/khjss.2015.41.3.005.

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Mori, Takayasu, Eriko Kikuchi, Yuko Watanabe, et al. "Chemical library screening for WNK signalling inhibitors using fluorescence correlation spectroscopy." Biochemical Journal 455, no. 3 (2013): 339–45. http://dx.doi.org/10.1042/bj20130597.

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To discover WNK–OSR1/SPAK signalling inhibitors, we generated a new high-throughput system using fluorescent correlation spectroscopy capable of screening compounds that disrupt the binding of two molecules. We finally identified two novel and promising compounds for WNK–OSR1/SPAK signalling inhibition.

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Wolff, Michael, Simone Krede, Dorothea Haasen, et al. "High Content Screening of CXCR2-Dependent Signalling Pathways." Combinatorial Chemistry & High Throughput Screening 13, no. 1 (2010): 3–15. http://dx.doi.org/10.2174/138620710790218249.

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Chu, Wujin. "Demand Signalling and Screening in Channels of Distribution." Marketing Science 11, no. 4 (1992): 327–47. http://dx.doi.org/10.1287/mksc.11.4.327.

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Antelo, Manel. "Screening and signalling for technology licensing: a comparison." R&D Management 42, no. 4 (2012): 289–302. http://dx.doi.org/10.1111/j.1467-9310.2012.00684.x.

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Dosis, Anastasios. "On signalling and screening in markets with asymmetric information." Journal of Mathematical Economics 75 (March 2018): 140–49. http://dx.doi.org/10.1016/j.jmateco.2018.01.001.

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Bassi, Vittorio, and Aisha Nansamba. "Screening and Signalling Non-Cognitive Skills: Experimental Evidence from Uganda." Economic Journal 132, no. 642 (2021): 471–511. http://dx.doi.org/10.1093/ej/ueab071.

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Abstract We study how employers and job seekers respond to credible information on skills that are difficult to observe, and how this affects matching in the labour market. We experimentally vary whether certificates on workers’ non-cognitive skills are disclosed to both sides of the market during job interviews between young workers and small firms in Uganda. The certificates cause workers to increase their labour market expectations, while high-ability managers revise their assessments of the workers’ skills upwards. The reaction in terms of beliefs leads to an increase in positive assortati

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Gründling, Angelika, and Vincent T. Lee. "Old concepts, new molecules and current approaches applied to the bacterial nucleotide signalling field." Philosophical Transactions of the Royal Society B: Biological Sciences 371, no. 1707 (2016): 20150503. http://dx.doi.org/10.1098/rstb.2015.0503.

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Signalling nucleotides are key molecules that help bacteria to rapidly coordinate cellular pathways and adapt to changes in their environment. During the past 10 years, the nucleotide signalling field has seen much excitement, as several new signalling nucleotides have been discovered in both eukaryotic and bacterial cells. The fields have since advanced quickly, aided by the development of important tools such as the synthesis of modified nucleotides, which, combined with sensitive mass spectrometry methods, allowed for the rapid identification of specific receptor proteins along with other n

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Dr. Abdul Nabi. "SCREENING OF MARINE BACTERIUM VIBRIO ALGINOLYTICUS STRAIN AS05 FOR THE PRODUCTION OF N-ACYL HOMOSERINE LACTONE-BASED QUORUM SENSING SIGNALING MOLECULES." Pakistan Journal of Science 74, no. 1-1 (2023): 7–11. http://dx.doi.org/10.57041/pjs.v74i1-1.791.

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Marine environments, including aquatic and coastal environments, are highly prevalent of marine bacteria with the highest levels of Vibrio species. Vibrios play a vital role in marine ecology associated with carbon and energy acquisition. The density-dependent quorum sensing (QS) system may regulate certain biological activities in marine bacteria. QS is a conversation system utilized by many bacterial communities to communicate and coordinate through different signalling molecules. N-acyl homoserine lactones (AHLs) are the most important QS signalling molecules widely produced by Gram-negativ

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Otero-Ramirez, Manuel E., Kyoko Matoba, Emiko Mihara, Toby Passioura, Junichi Takagi, and Hiroaki Suga. "Macrocyclic peptides that inhibit Wnt signalling via interaction with Wnt3a." RSC Chemical Biology 1, no. 1 (2020): 26–34. http://dx.doi.org/10.1039/d0cb00016g.

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Discovery and optimization of de novo macrocyclic peptide binders of Wnt3a through RaPID screening against an afamin-stabilized Wnt3a complex, capable of inhibiting Wnt signalling by direct interaction to the Wnt protein.

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Thèses sur le sujet "Screening, Signalling"

MARCHESI, SILVIA. "Screening and Signalling in Debt Strategies: Theory and Empirics." Doctoral thesis, University of Warwick, 2001. http://hdl.handle.net/10281/4658.

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This thesis focuses on public debt under asymmetry of information. The first part of the thesis deals with foreign debt while the second part with domestic debt. In the first part of this work (Chapter 1 and 2) a theoretical model is developed in which adoption of an IMF programme signals a country's productivity. It is assumed that there are two types of country, one with a high return on investment and the other with a low return. The country's type is known only to itself. In the presence of a debt overhang, the high productivity country may choose not to undertake the investment, despite

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Lin, Kuan Chee Bevan. "Using the RISCI genetic screening platform for elucidating apoptosis signalling network." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/11662.

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Considerable development in the field of nanotechnology is increasingly yielding novel applications of nanoparticles. The unique properties of nanoparticles in particular their high aspect ratio (length : width ratio), however could pose potential risks to the user. A high throughput genetic screening platform, RISCI (robotic single cDNA investigation), was previously established for the systematic evaluation of single gene activities. Here, RISCI was utilised to identify pro-apoptotic genes as well as genes involved in the positive and negative regulation of silica nanoparticle-induced cell d

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Lloyd-Lewis, Bethan. "High-throughput screening for novel regulators of Beta-catenin in Wnt signalling." Thesis, Cardiff University, 2011. http://orca.cf.ac.uk/24229/.

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Beta-catenin is a crucial component of the Wnt signalling pathway, which is imperative in many developmental processes and aberrantly regulated in several different cancers. The standard model of Wnt/Beta-catenin signalling states that, upon stimulation by Wnt ligand, Beta-catenin accumulates and subsequently translocates to the nucleus to activate TCF-dependent transcription of a variety of target genes, including oncogenes. However, the mechanisms regulating the nuclear localisation of Beta-catenin and its correlation with TCF-dependent transcription are poorly understood. In order to identi

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Bielig, Harald Frank Verfasser], Jonathan [Akademischer Betreuer] Howard, and Mats [Akademischer Betreuer] [Paulsson. "Screening for components involved in NLR-mediated immune signalling / Harald Frank Bielig. Gutachter: Jonathan Howard ; Mats Paulsson." Köln : Universitäts- und Stadtbibliothek Köln, 2012. http://d-nb.info/1038226805/34.

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Rudge, Felicity. "Genome-wide cDNA and RNAi screening to identify modulators of responses to a novel Wnt signalling inhibitor." Thesis, Cardiff University, 2013. http://orca.cf.ac.uk/58589/.

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Wnt/β-catenin signalling plays a central role in the regulation of multicelluar organism development and in the maintenance of tissue homeostasis in adults. Dysregulation of Wnt signalling resulting in aberrant pathway activation is a key initiating step in the development of a diverse range of cancers, including colorectal cancer, and as such is an important target for therapeutic intervention. A novel Wnt pathway inhibitor, ‘MSC’, has been identified as blocking activated Wnt signalling, specifically through inhibiting the ability of CDK8 and CDK19 to activate nuclear β-catenin/TCF-dependent

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Bielig, Harald Frank [Verfasser], Jonathan Akademischer Betreuer] Howard, and Mats [Akademischer Betreuer] [Paulsson. "Screening for components involved in NLR-mediated immune signalling / Harald Frank Bielig. Gutachter: Jonathan Howard ; Mats Paulsson." Köln : Universitäts- und Stadtbibliothek Köln, 2012. http://d-nb.info/1038226805/34.

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Matsuo, Koji. "Significance of dopamine D1 receptor signalling for steroidogenic differentiation of human induced pluripotent stem cells." Kyoto University, 2018. http://hdl.handle.net/2433/232124.

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Lago, Cooke Santiago Guillermo. "A novel pipeline for drug discovery in neuropsychiatric disorders using high-content single-cell screening of signalling network responses ex vivo." Thesis, University of Cambridge, 2016. https://www.repository.cam.ac.uk/handle/1810/270297.

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The current work entails the development of a novel high content platform for the measurement of kinetic ligand responses across cell signalling networks at the single-cell level in distinct PBMC subtypes ex vivo. Using automated sample preparation, fluorescent cellular barcoding and flow cytometry the platform is capable of detecting 21, 840 parallel cell signalling responses in each PBMC sample. We apply this platform to characterize the effects of neuropsychiatric treatments and CNS ligands on the T cell signalling repertoire. We apply it to define cell signalling network abnormalities in P

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Whalen, Daniel M. "Structural and functional studies of the hedgehog signalling pathway." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:ce0e765c-04f1-4a64-a67b-89204ecaa155.

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Hedgehog (Hh) morphogens play fundamental roles in development whilst dysregulation of Hh signalling leads to disease. Multiple receptors are involved in the modulation of Hh morphogens at the cell surface. Among these, the interactions of Hh ligands with glycosaminoglycan (GAG) (for example heparan or chondroitin sulphate) chains of proteoglycans in the extracellular matrix play a key role in shaping morphogen gradients and fulfil important functions in signal transduction. Several high resolution crystal structures of Sonic Hh (Shh)-GAG complexes have been determined. The interaction determi

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ALFRED, VICTOR IFEOLUWA. "GENETIC SCREENING TO IDENTIFY INTERACTORS OF ESCRT-II SUBUNIT, VPS25, AND PRELIMINARY CHARACTERISATION OF CANDIDATES." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/560382.

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ESCRT (Endosomal Sorting Complex Required for Transport) proteins regulate cell surface receptor degradation by sorting and packaging ubiquitinated cargoes into the intraluminal vesicles of multivesicular bodies (MVBs). A range of human diseases including cancer, and neurodegeneration display altered expression or are caused by mutations of ESCRT subunits. Studies have shown that Drosophila tissues lacking ESCRTs display neoplastic-like features like overproliferation and polarity defects, partly due to aberrant signalling including Notch signalling. To understand ESCRT-regulated processes in

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Livres sur le sujet "Screening, Signalling"

Dolton, Peter J. Signalling and screening in the graduate labour market. University of Hull. Dept of Economics and Commerce, 1985.

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Dolton, Peter J. Signalling and screening in the graduate labour market. University of Hull, 1986.

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Gómez, Maria José Carrascosa. Abiotic stress: Screening and characterisation of signalling mutants. 2002.

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Chapitres de livres sur le sujet "Screening, Signalling"

Hörner, Johannes. "Signalling and Screening." In The New Palgrave Dictionary of Economics. Palgrave Macmillan UK, 2008. http://dx.doi.org/10.1057/978-1-349-95121-5_2097-1.

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Hörner, Johannes. "Signalling and Screening." In The New Palgrave Dictionary of Economics. Palgrave Macmillan UK, 2018. http://dx.doi.org/10.1057/978-1-349-95189-5_2097.

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Kaestner, Lars. "A system for optical high resolution screening of electrical excitable cells." In Calcium signalling. Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-34617-0_13.

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Feno, Simona, Giulia Di Marco, Agnese De Mario, Halenya Monticelli, and Denis Vecellio Reane. "High-Throughput Screening Using Photoluminescence Probe to Measure Intracellular Calcium Levels." In Calcium Signalling. Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9018-4_1.

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Hucke, Anja. "Screening und Signalling als vorvertragliche Auswahlmechanismen." In Gesellschafter und Geschäftsführer der GmbH. Deutscher Universitätsverlag, 1996. http://dx.doi.org/10.1007/978-3-663-08520-1_3.

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Bollati-Fogolín, M., M. Oggero, S. Mirazo, R. Frank, R. Kratje, and W. Müller. "Screening of Natural Compounds Affecting Type I Interferon Signalling." In Cells and Culture. Springer Netherlands, 2010. http://dx.doi.org/10.1007/978-90-481-3419-9_86.

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Joll, Caroline, Chris Mckenna, Robert Mcnabb, and John Shorey. "Uncertainty, screening and signalling." In Developments in Labour Market Analysis. Routledge, 2018. http://dx.doi.org/10.4324/9780429025204-5.

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Chew, Shern L. "Molecular aspects of hormonal regulation." In Oxford Textbook of Endocrinology and Diabetes. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199235292.003.1024.

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The wide molecular effects of hormones have complicated the understanding of how hormones work on a cell. The old view was of a linear signalling pathway from the receptor to the nucleus, thereby stimulating gene transcription. This view is probably an oversimplification. Hormones can not only regulate most of the molecular machines of the cell, certainly the transcription machinery, but also others. These machines perform and coordinate functions such as RNA and protein biosynthesis, macromolecular transport, cell division or death, and intracellular signalling. Physiological studies have sho

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Hong, Shyang Pei, Siti Nurul Azian Zakaria, and Minhaz Uddin Ahmed. "Advancement and Application of Nanomaterials Towards Cost-effective Immunosensing Platforms for Food Allergens." In Low-cost Diagnostics. Royal Society of Chemistry, 2024. https://doi.org/10.1039/9781837673216-00080.

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Food allergies are a significant public health concern worldwide, affecting 5 to 10% of the population in developed nations. To increase customer confidence and provide more food options, it is crucial to enforce accurate labelling of food allergens. One efficient approach to achieve this is by detecting or confirming the presence of micro-, pico-, or even femtogram-level traces of food allergens in processed food products through the limit of detection (LOD). Nanomaterials (NMs) can enhance detection sensitivity and efficiency via electrical signal transduction by interfacing with bioreceptor

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Malakar, Ayushman, Sudhan Singh Kaintura, Santan Barthwal, and Sandip Debnath. "EXPLORING BIO-SIGNALLING PATHWAYS UNDER COLD STRESS IN FOREST TREES: A CRITICAL REVIEW." In Futuristic Trends in Biotechnology Volume 2 Book 26. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2023. http://dx.doi.org/10.58532/v2bs26ch6.

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The objective of breeding and development programmes for cold-hardy forest trees is to provide non-destructive laboratory procedures for evaluating the trees' cold tolerance. Through the expression of stress-responsive genes, forest plants are able to tolerate the cold. In cells, the Cold regulated genes (CORs) are implicated in cold and frost defense. CBFs (C-repeat Binding Factors) regulate a variety of genes involved in osmolyte synthesis and other protective processes as mediators during cold stress and its acclimation in higher plants. Several biochemical techniques, including the detecti

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Actes de conférences sur le sujet "Screening, Signalling"

"Screening and Signalling in a Contractual Savings for Housing System: The German Bausparkassen System." In 9th European Real Estate Society Conference: ERES Conference 2002. ERES, 2002. http://dx.doi.org/10.15396/eres2002_221.

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Takayama, Shuichi, Yi-Chung Tung, and Bor-Han Chueh. "Biological Micro/Nanofluidics." In ASME 2008 First International Conference on Micro/Nanoscale Heat Transfer. ASMEDC, 2008. http://dx.doi.org/10.1115/mnht2008-52087.

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Many biological studies, drug screening methods, and cellular therapies require culture and manipulation of living cells outside of their natural environment in the body. The gap between the cellular microenvironment in vivo and in vitro, however, poses challenges for obtaining physiologically relevant responses from cells used in basic biological studies or drug screens and for drawing out the maximum functional potential from cells used therapeutically. One of the reasons for this gap is because the fluidic environment of mammalian cells in vivo is microscale and dynamic whereas typical in v

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Dutta Roy, T., J. J. Stone, W. Sun, et al. "Osteoblast Adhesion on Tissue Engineering Scaffolds Made by Bio-Manufacturing Techniques." In ASME 2005 International Mechanical Engineering Congress and Exposition. ASMEDC, 2005. http://dx.doi.org/10.1115/imece2005-82472.

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Scientific exploration into understanding and developing relationships between three-dimensional (3D) scaffolds prepared by rapid prototyping (RP) and cellular response has focused primarily on end results targeting osteoblast proliferation and differentiation. Here at the National Institute of Standards and Technology (NIST), we take a systems approach to developing relationships between material properties and quantitative biological responses. This study in particular focuses on the screening of parameters controlled by RP techniques and their ability to trigger signalling events leading to

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Rapports d'organisations sur le sujet "Screening, Signalling"

Miller, Gad, and Jeffrey F. Harper. Pollen fertility and the role of ROS and Ca signaling in heat stress tolerance. United States Department of Agriculture, 2013. http://dx.doi.org/10.32747/2013.7598150.bard.

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The long-term goal of this research is to understand how pollen cope with stress, and identify genes that can be manipulated in crop plants to improve reproductive success during heat stress. The specific aims were to: 1) Compare heat stress dependent changes in gene expression between wild type pollen, and mutants in which pollen are heat sensitive (cngc16) or heat tolerant (apx2-1). 2) Compare cngc16 and apx2 mutants for differences in heat-stress triggered changes in ROS, cNMP, and Ca²⁺ transients. 3) Expand a mutant screen for pollen with increased or decreased thermo-tolerance. These aims

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