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Articles de revues sur le sujet « Screening, Signalling »

Auteur : Grafiati

Publié le 9 mars 2023

Mis à jour le 31 juillet 2025

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1

Jeong-Yoo Kim. "Signalling and Screening of Harsh Religious Norms." Journal of Social Science 41, no. 3 (2015): 103–16. http://dx.doi.org/10.15820/khjss.2015.41.3.005.

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Mori, Takayasu, Eriko Kikuchi, Yuko Watanabe, et al. "Chemical library screening for WNK signalling inhibitors using fluorescence correlation spectroscopy." Biochemical Journal 455, no. 3 (2013): 339–45. http://dx.doi.org/10.1042/bj20130597.

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To discover WNK–OSR1/SPAK signalling inhibitors, we generated a new high-throughput system using fluorescent correlation spectroscopy capable of screening compounds that disrupt the binding of two molecules. We finally identified two novel and promising compounds for WNK–OSR1/SPAK signalling inhibition.

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Wolff, Michael, Simone Krede, Dorothea Haasen, et al. "High Content Screening of CXCR2-Dependent Signalling Pathways." Combinatorial Chemistry & High Throughput Screening 13, no. 1 (2010): 3–15. http://dx.doi.org/10.2174/138620710790218249.

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Chu, Wujin. "Demand Signalling and Screening in Channels of Distribution." Marketing Science 11, no. 4 (1992): 327–47. http://dx.doi.org/10.1287/mksc.11.4.327.

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Antelo, Manel. "Screening and signalling for technology licensing: a comparison." R&D Management 42, no. 4 (2012): 289–302. http://dx.doi.org/10.1111/j.1467-9310.2012.00684.x.

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Dosis, Anastasios. "On signalling and screening in markets with asymmetric information." Journal of Mathematical Economics 75 (March 2018): 140–49. http://dx.doi.org/10.1016/j.jmateco.2018.01.001.

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Bassi, Vittorio, and Aisha Nansamba. "Screening and Signalling Non-Cognitive Skills: Experimental Evidence from Uganda." Economic Journal 132, no. 642 (2021): 471–511. http://dx.doi.org/10.1093/ej/ueab071.

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Abstract We study how employers and job seekers respond to credible information on skills that are difficult to observe, and how this affects matching in the labour market. We experimentally vary whether certificates on workers’ non-cognitive skills are disclosed to both sides of the market during job interviews between young workers and small firms in Uganda. The certificates cause workers to increase their labour market expectations, while high-ability managers revise their assessments of the workers’ skills upwards. The reaction in terms of beliefs leads to an increase in positive assortati

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Gründling, Angelika, and Vincent T. Lee. "Old concepts, new molecules and current approaches applied to the bacterial nucleotide signalling field." Philosophical Transactions of the Royal Society B: Biological Sciences 371, no. 1707 (2016): 20150503. http://dx.doi.org/10.1098/rstb.2015.0503.

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Signalling nucleotides are key molecules that help bacteria to rapidly coordinate cellular pathways and adapt to changes in their environment. During the past 10 years, the nucleotide signalling field has seen much excitement, as several new signalling nucleotides have been discovered in both eukaryotic and bacterial cells. The fields have since advanced quickly, aided by the development of important tools such as the synthesis of modified nucleotides, which, combined with sensitive mass spectrometry methods, allowed for the rapid identification of specific receptor proteins along with other n

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Dr. Abdul Nabi. "SCREENING OF MARINE BACTERIUM VIBRIO ALGINOLYTICUS STRAIN AS05 FOR THE PRODUCTION OF N-ACYL HOMOSERINE LACTONE-BASED QUORUM SENSING SIGNALING MOLECULES." Pakistan Journal of Science 74, no. 1-1 (2023): 7–11. http://dx.doi.org/10.57041/pjs.v74i1-1.791.

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Marine environments, including aquatic and coastal environments, are highly prevalent of marine bacteria with the highest levels of Vibrio species. Vibrios play a vital role in marine ecology associated with carbon and energy acquisition. The density-dependent quorum sensing (QS) system may regulate certain biological activities in marine bacteria. QS is a conversation system utilized by many bacterial communities to communicate and coordinate through different signalling molecules. N-acyl homoserine lactones (AHLs) are the most important QS signalling molecules widely produced by Gram-negativ

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Otero-Ramirez, Manuel E., Kyoko Matoba, Emiko Mihara, Toby Passioura, Junichi Takagi, and Hiroaki Suga. "Macrocyclic peptides that inhibit Wnt signalling via interaction with Wnt3a." RSC Chemical Biology 1, no. 1 (2020): 26–34. http://dx.doi.org/10.1039/d0cb00016g.

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Discovery and optimization of de novo macrocyclic peptide binders of Wnt3a through RaPID screening against an afamin-stabilized Wnt3a complex, capable of inhibiting Wnt signalling by direct interaction to the Wnt protein.

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Fang, Qing, Fleurdeliz Maglangit, Linrui Wu, et al. "Signalling and Bioactive Metabolites from Streptomyces sp. RK44." Molecules 25, no. 3 (2020): 460. http://dx.doi.org/10.3390/molecules25030460.

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Streptomyces remains one of the prolific sources of structural diversity, and a reservoir to mine for novel natural products. Continued screening for new Streptomyces strains in our laboratory led to the isolation of Streptomyces sp. RK44 from the underexplored areas of Kintampo waterfalls, Ghana, Africa. Preliminary screening of the metabolites from this strain resulted in the characterization of a new 2-alkyl-4-hydroxymethylfuran carboxamide (AHFA) 1 together with five known compounds, cyclo-(L-Pro-Gly) 2, cyclo-(L-Pro-L-Phe) 3, cyclo-(L-Pro-L-Val) 4, cyclo-(L-Leu-Hyp) 5, and deferoxamine E

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McCullough, Samuel, Eliene Albers, Akshata Anchan, Jane Yu, Bronwen Connor, and E. Scott Graham. "Screening Activity of Brain Cancer-Derived Factors on Primary Human Brain Pericytes." Onco 4, no. 4 (2024): 381–96. http://dx.doi.org/10.3390/onco4040027.

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Background/Objectives: Brain cancers offer poor prognoses to patients accompanied by symptoms that drastically impact the patient and their family. Brain tumours recruit local non-transformed cells to provide trophic support and immunosuppression within the tumour microenvironment, supporting tumour progression. Given the localisation and supportive role of pericytes at the brain vasculature, we explored the potential for brain pericytes to contribute to the brain cancer microenvironment. Methods: To investigate this, primary brain pericytes were treated with factors commonly upregulated in br

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Pérez-Novo, Claudina A., Amber Driesen, Maaike Van Trimpont, et al. "Epigenetic Rewiring of Protein Kinase Signalling in T-Cell Acute Lymphoblastic Leukaemia." Kinases and Phosphatases 3, no. 2 (2025): 7. https://doi.org/10.3390/kinasesphosphatases3020007.

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T-cell acute lymphoblastic leukaemia (T-ALL) is an aggressive neoplastic malignancy characterised by the accumulation of multiple oncogenic and epigenetic alterations in haematopoietic T-cell precursors leading to their uncontrolled proliferation and accumulation in the bone marrow. For many years it has been established that the occurrence of activating mutations, alterations in transcription factors expression, impairment in cell cycle regulators, and hyperactivation of NOTCH1 signalling play prominent roles in the pathogenesis of this disease. Recently, the introduction of high-resolution s

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Campbell, Michelle, Sophie J. Stephenson, Kevin Whale, et al. "A screening platform for human plasma cells (PCs) reveals a selective response to SYK inhibition." Journal of Immunology 202, no. 1_Supplement (2019): 123.23. http://dx.doi.org/10.4049/jimmunol.202.supp.123.23.

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Abstract Therapeutic targeting of PC populations has potential value in various auto-immune, allergic and neoplastic cell states, but at present few options exist for selective targeting. However, the unique physiology and niche dependence of PCs suggests that such targeting may be achievable. To this end we have developed a sensitive screening platform capable of detecting changes in PC biology. Starting from our published methods for in vitro PC generation we optimised conditions to allow maintenance of PCs in polarised niche environments reflective of homeostatic and inflammatory conditions

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Staten, Michael, Otis Gilley, and John Umbeck. "SCREENING AND SIGNALLING IN CONSUMER CREDIT: A THEORY OF INDIRECT LENDING." Financial Review 22, no. 3 (1987): 114. http://dx.doi.org/10.1111/j.1540-6288.1987.tb01248.x.

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Kiss-Toth, E., D. H. Wyllie, K. Holland, et al. "Functional mapping of Toll/interleukin-1 signalling networks by expression cloning." Biochemical Society Transactions 33, no. 6 (2005): 1405–6. http://dx.doi.org/10.1042/bst0331405.

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Multiple cellular proteins have been identified as participating in Toll/interleukin-1 receptor-mediated inflammatory gene expression. The continuing isolation of novel components, based on sequence similarities, protein–protein interactions and protein purification, suggests that many elements of this signalling network remain to be identified. We report here the development of a high-throughput functional screening platform and its application for the identification of components of inflammatory signalling networks. Our results enable us to estimate that 100–150 gene products are involved in

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Choi, Jeongmin, Kiwamu Tanaka, Yan Liang, Yangrong Cao, Sang Yeol Lee, and Gary Stacey. "Extracellular ATP, a danger signal, is recognized by DORN1 in Arabidopsis." Biochemical Journal 463, no. 3 (2014): 429–37. http://dx.doi.org/10.1042/bj20140666.

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ATP, the universal energy currency of all organisms, is released into the extracellular matrix and serves as a signal among cells, where it is referred to as an extracellular ATP. Although a signalling role for extracellular ATP has been well studied in mammals over the last 40 years, investigations of such a role in plants are at an early stage. Recently, the first plant receptor for extracellular ATP, DOes not Respond to Nucleotides (DORN1), was identified in Arabidopsis thaliana by mutant screening. DORN1 encodes a legume-type lectin receptor kinase that is structurally distinct from the ma

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Beeraka, Narasimha M., Jin Zhang, Subhankar Mandal, et al. "Screening fructosamine-3-kinase (FN3K) inhibitors, a deglycating enzyme of oncogenic Nrf2: Human FN3K homology modelling, docking and molecular dynamics simulations." PLOS ONE 18, no. 11 (2023): e0283705. http://dx.doi.org/10.1371/journal.pone.0283705.

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Fructosamine-3-kinase (FN3K) is involved in the deglycation of Nrf2, a significant regulator of oxidative stress in cancer cells. However, the intricate functional aspects of FN3K and Nrf2 in breast cancers have not been explored vividly. The objectives of this study are to design the human FN3K protein using homology modeling followed by the screening of several anticancer molecules and examining their efficacy to modulate FN3K activity, Nrf2-mediated antioxidant signalling. Methods pertinent to homology modeling, virtual screening, molecular docking, molecular dynamics simulations, assessmen

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Dong, Chuanfu, Franziska Dolke, and Stephan H. von Reuss. "Selective MS screening reveals a sex pheromone in Caenorhabditis briggsae and species-specificity in indole ascaroside signalling." Organic & Biomolecular Chemistry 14, no. 30 (2016): 7217–25. http://dx.doi.org/10.1039/c6ob01230b.

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Liu, Ronghan, Yuehong Chen, Wenyu Fu, et al. "Fexofenadine inhibits TNF signaling through targeting to cytosolic phospholipase A2 and is therapeutic against inflammatory arthritis." Annals of the Rheumatic Diseases 78, no. 11 (2019): 1524–35. http://dx.doi.org/10.1136/annrheumdis-2019-215543.

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ObjectiveTumour necrosis factor alpha (TNF-α) signalling plays a central role in the pathogenesis of various autoimmune diseases, particularly inflammatory arthritis. This study aimed to repurpose clinically approved drugs as potential inhibitors of TNF-α signalling in treatment of inflammatory arthritis.MethodsIn vitro and in vivo screening of an Food and Drug Administration (FDA)-approved drug library; in vitro and in vivo assays for examining the blockade of TNF actions by fexofenadine: assays for defining the anti-inflammatory activity of fexofenadine using TNF-α transgenic (TNF-tg) mice a

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Kakeya, Hideaki. "Natural products-prompted chemical biology: phenotypic screening and a new platform for target identification." Natural Product Reports 33, no. 5 (2016): 648–54. http://dx.doi.org/10.1039/c5np00120j.

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This highlight focuses on our recent discoveries and chemical genetics approaches for bioactive microbial metabolites that target cancer cells, the cancer microenvironment, and cell membrane signalling. In addition, the development of two new platforms to identify the cellular targets of these molecules is also discussed.

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Dower, S. K., and E. E. Qwarnstrom. "Signalling networks, inflammation and innate immunity." Biochemical Society Transactions 31, no. 6 (2003): 1462–71. http://dx.doi.org/10.1042/bst0311462.

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We have been analysing the signalling systems that couple to receptors of the TIR (Toll/interleukin-1 receptor) family, which signal through a common cytoplasm region; the TIR domain. These systems are of both practical and fundamental biological significance, being central to the pathogenesis of chronic inflammatory diseases such as atherosclerosis, to host defence throughout the biological world, and are ancient in the context of life on earth, having originated more than 1 billion years ago: prior to the divergence of plants and animals. TIR domain receptors couple to at least two sets of w

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Foulkes, Daniel M., Dominic P. Byrne, Fiona P. Bailey, and Patrick A. Eyers. "Tribbles pseudokinases: novel targets for chemical biology and drug discovery?" Biochemical Society Transactions 43, no. 5 (2015): 1095–103. http://dx.doi.org/10.1042/bst20150109.

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Tribbles (TRIB) proteins are pseudokinase mediators of eukaryotic signalling that have evolved important roles in lipoprotein metabolism, immune function and cellular differentiation and proliferation. In addition, an evolutionary-conserved modulation of PI3K/AKT signalling pathways highlights them as novel and rather unusual pharmaceutical targets. The three human TRIB family members are uniquely defined by an acidic pseudokinase domain containing a ‘broken’ α C-helix and a MEK (MAPK/ERK)-binding site at the end of the putative C-lobe and a distinct C-terminal peptide motif that interacts dir

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Cheng, Lin, Yun Zhao, and Hong Ke. "Screening for Immune-Related RNA Biomarkers of Aneurysmal Subarachnoid Hemorrhage." Clinical and Investigative Medicine 45, no. 2 (2022): E28–38. http://dx.doi.org/10.25011/cim.v45i2.38449.

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Purpose: Through comprehensive bioinformatics analysis based on the immune microenvironment, this study aimed to identify immune-related RNA biomarkers that indicate aneurysmal subarachnoid hemorrhage (aSAH). Methods: The GSE73378 dataset was downloaded from the National Center for Biotechnology Information GEO database, providing blood from 107 normal controls and 103 patients with aSAH. The immune infiltration types in the aSAH blood samples were assessed and RNAs that were differentially expressed (DE) between 1) the aSAH and control groups and 2) the immune infiltration groups (high and lo

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Vijayakrishnan, N., and K. Broadie. "Temperature-sensitive paralytic mutants: insights into the synaptic vesicle cycle." Biochemical Society Transactions 34, no. 1 (2006): 81–87. http://dx.doi.org/10.1042/bst0340081.

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Forward genetic screens have identified numerous proteins with critical roles in neurotransmission. One particularly fruitful screening target in Drosophila has been TS (temperature-sensitive) paralytic mutants, which have revealed proteins acutely required in neuronal signalling. In the present paper, we review recent insights and current questions from one recently cloned TS paralytic mutant, rbo (rolling blackout). The rbo mutant identifies a putative integral lipase of the pre-synaptic plasma membrane that is required for the SV (synaptic vesicle) cycle. Identification of this mutant adds

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Marconi, Guya Diletta, Cristina Porcheri, Oriana Trubiani, and Thimios A. Mitsiadis. "Three-Dimensional Culture Systems for Dissecting Notch Signalling in Health and Disease." International Journal of Molecular Sciences 22, no. 22 (2021): 12473. http://dx.doi.org/10.3390/ijms222212473.

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Three-dimensional (3D) culture systems opened up new horizons in studying the biology of tissues and organs, modelling various diseases, and screening drugs. Producing accurate in vitro models increases the possibilities for studying molecular control of cell–cell and cell–microenvironment interactions in detail. The Notch signalling is linked to cell fate determination, tissue definition, and maintenance in both physiological and pathological conditions. Hence, 3D cultures provide new accessible platforms for studying activation and modulation of the Notch pathway. In this review, we provide

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Cai, Kaifan, Zhining Guo, and Yanlong Huang. "The current status and prospects of research on orphan G protein-coupled receptor." Theoretical and Natural Science 27, no. 1 (2023): 241–50. http://dx.doi.org/10.54254/2753-8818/27/20240742.

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This review provides an overview of the current status and prospects of research on orphan G protein-coupled receptors (oGPCRs). It begins by discussing the classification and structure of GPCRs and then delves into the methods used to identify and characterize ligands for oGPCRs, including ligand screening strategies, correlation analysis, functional analysis techniques, and interaction evaluations. The review further examines the functionality and de-orphanization research of specific oGPCRs, such as GPR35, GPR55, GPR75, and GPR88. It discusses their basic information, signalling pathways, r

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di Martino, Erica, Darren C. Tomlinson, and Margaret A. Knowles. "A Decade of FGF Receptor Research in Bladder Cancer: Past, Present, and Future Challenges." Advances in Urology 2012 (2012): 1–10. http://dx.doi.org/10.1155/2012/429213.

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Fibroblast growth factors (FGFs) orchestrate a variety of cellular functions by binding to their transmembrane tyrosine-kinase receptors (FGFRs) and activating downstream signalling pathways, including RAS/MAPK, PLCγ1, PI3K, and STATs. In the last ten years, it has become clear that FGF signalling is altered in a high proportion of bladder tumours. Activating mutations and/or overexpression ofFGFR3are common in urothelial tumours with low malignant potential and low-stage and -grade urothelial carcinomas (UCs) and are associated with a lower risk of progression and better survival in some subg

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Pietrzak, Michał. "Information Asymmetry, Signalling and Screening vs. Audit Culture – Selected Challenges for Academic Governance." Problemy Zarzadzania 4/2018, no. 77 (2019): 134–52. http://dx.doi.org/10.7172/1644-9584.77.8.

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Bisserier, Malik, Jean-Paul Blondeau, and Frank Lezoualc’h. "Epac proteins: specific ligands and role in cardiac remodelling." Biochemical Society Transactions 42, no. 2 (2014): 257–64. http://dx.doi.org/10.1042/bst20140033.

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Epacs (exchange proteins directly activated by cAMP) act as guanine-nucleotide-exchange factors for the Ras-like small G-proteins Rap1 and Rap2, and are now recognized as incontrovertible factors leading to complex and diversified cAMP signalling pathways. Given the critical role of cAMP in the regulation of cardiac function, several studies have investigated the functional role of Epacs in the heart, providing evidence that Epacs modulate intracellular Ca2+ and are involved in several cardiac pathologies such as cardiac hypertrophy and arrhythmia. The present review summarizes recent data on

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Miguel González, J. A., P. Pavlidis, and U. M. Marigorta. "P105 Mendelian Randomization screening for JAK inhibitor related potential serious adverse events." Journal of Crohn's and Colitis 18, Supplement_1 (2024): i388. http://dx.doi.org/10.1093/ecco-jcc/jjad212.0235.

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Abstract Background JAK inhibitors (JAKi) suppress the JAK/STAT signalling pathway through inhibition of the four Janus kinase proteins JAK1, JAK2, JAK3 and TYK2. JAKi are licensed for the treatment of a wide range of immune mediated inflammatory diseases (IMIDs) including inflammatory bowel disease. Concerns have been raised for the potential of this class of medication to associate with serious adverse events, particularly in those older than 65 years of age or with previous cardiovascular comorbidities. Mendelian randomization (MR) uses genetic variants as instrumental variables (IVs) to ex

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S. Kalaivanan, S. Showbharnikhaa, T. Thenmozhi, et al. "In-vitro and In-vivo screening methods for targeting HMBG1 in RA: A comprehensive overview." International Journal of Science and Research Archive 12, no. 2 (2024): 606–21. http://dx.doi.org/10.30574/ijsra.2024.12.2.1237.

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Targeting High Mobility Group Box 1 (HMGB1) in rheumatoid arthritis (RA) holds promise for mitigating inflammation and joint damage. This paper comprehensively overviews In Vitro and In Vivo screening methods for HMGB1 targeting in RA. In Vitro, assays include cell-based assays, ELISA, and Western blotting to assess HMGB1 release, receptor activation, and downstream signalling pathways. In Vivo, models such as collagen-induced arthritis (CIA) in mice and adjuvant-induced arthritis (AIA) in rats mimic RA pathogenesis and enable evaluation of HMGB1 inhibitors' efficacy, safety, and pharmacokinet

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Chong, Irene Yu-Shing, Sean D. Hooper, David Cunningham, et al. "Association of high-throughput RNAi and drug screening with candidate novel therapeutic targets in esophageal carcinoma." Journal of Clinical Oncology 31, no. 4_suppl (2013): 31. http://dx.doi.org/10.1200/jco.2013.31.4_suppl.31.

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31 Background: Oesophageal cancer is the sixth most commonly diagnosed cancer worldwide and carries a poor prognosis. Targeted therapeutic strategies have relied on the identification of genes which are amplified and overexpressed but the discrimination between genes which drive cancer and those that are coincidental has not yet been fully achieved. Methods: We carried out a functional genetic screen of 714 kinases in 18 tumour cell line models of oesophageal adenocarcinoma (EAC) and squamous cell carcinoma (SCC) to identify genes critical to the survival of specific oesophageal subtypes. High

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Hayes, Sheri, Beatrice Malacrida, Maeve Kiely, and Patrick A. Kiely. "Studying protein–protein interactions: progress, pitfalls and solutions." Biochemical Society Transactions 44, no. 4 (2016): 994–1004. http://dx.doi.org/10.1042/bst20160092.

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Signalling proteins are intrinsic to all biological processes and interact with each other in tightly regulated and orchestrated signalling complexes and pathways. Characterization of protein binding can help to elucidate protein function within signalling pathways. This information is vital for researchers to gain a more comprehensive knowledge of cellular networks which can then be used to develop new therapeutic strategies for disease. However, studying protein–protein interactions (PPIs) can be challenging as the interactions can be extremely transient downstream of specific environmental

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Menon, Manoj B., and Matthias Gaestel. "TPL2 meets p38MAPK: emergence of a novel positive feedback loop in inflammation." Biochemical Journal 473, no. 19 (2016): 2995–99. http://dx.doi.org/10.1042/bcj20160672c.

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The activation of p38MAPK by Toll-like receptor signalling is essential for the inflammatory response of innate immunity due to its role in post-transcriptional regulation of TNFα and cytokine biosynthesis. p38MAPK activation proceeds by the upstream MAP2Ks, MAPK kinase (MKK)3/6 as well as MKK4, which in turn are substrates for MAP3Ks, such as TGFβ-activated protein kinase-1 (TAK1). In contrast, TPL2 has been described as an exclusive MAP3K of MKK1/2-triggering activation of the classical ERKs, ERK1/2. In the recent issue of the Biochemical Journal, Pattison et al. report their screening for T

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Kashyap, Abhishek, Dimpy Rani, Suresh Kumar, and Shailendra Bhatt. "Design and Computational Evaluation of New Carbamate Derivatives for the Inhibition of Monoacylglycerol Lipase Enzyme by using Docking." International Journal of Pharmaceutical Sciences and Drug Research 15, no. 05 (2023): 665–74. http://dx.doi.org/10.25004/ijpsdr.2023.150515.

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Different disorders and physiological process have been found to be associated with monoacylglycerol lipase enzyme in humans, like pain, inflammation, and neurodegenerative diseases also. The enzyme is a 33 KDa in weight and a type of serine hydrolase enzyme in nature. The presence of enzyme has been reported in both central and peripheral nervous systems and has show its importance as a key signalling factor in endocannabinoid signalling network system. The enzyme has also reported as source of free fatty acid provider for the cancer cell and tumor growth and their proliferation. In prolifera

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Agrawal, Neha, Katherine Lawler, Catherine M. Davidson, et al. "Predicting novel candidate human obesity genes and their site of action by systematic functional screening in Drosophila." PLOS Biology 19, no. 11 (2021): e3001255. http://dx.doi.org/10.1371/journal.pbio.3001255.

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The discovery of human obesity-associated genes can reveal new mechanisms to target for weight loss therapy. Genetic studies of obese individuals and the analysis of rare genetic variants can identify novel obesity-associated genes. However, establishing a functional relationship between these candidate genes and adiposity remains a significant challenge. We uncovered a large number of rare homozygous gene variants by exome sequencing of severely obese children, including those from consanguineous families. By assessing the function of these genes in vivo in Drosophila, we identified 4 genes,

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Zhang, Siqi, Qiaoling Song, Xueting Wang, et al. "Virtual Screening Guided Design, Synthesis and Bioactivity Study of Benzisoselenazolones (BISAs) on Inhibition of c-Met and Its Downstream Signalling Pathways." International Journal of Molecular Sciences 20, no. 10 (2019): 2489. http://dx.doi.org/10.3390/ijms20102489.

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c-Met is a transmembrane receptor tyrosine kinase and an important therapeutic target for anticancer drugs. In this study, we designed a small library containing 300 BISAs molecules that consisted of carbohydrates, amino acids, isothiourea, tetramethylthiourea, guanidine and heterocyclic groups and screened c-Met targeting compounds using docking and MM/GBSA. Guided by virtual screening, we synthesised a series of novel compounds and their activity on inhibition of the autophosphorylation of c-Met and its downstream signalling pathway proteins were evaluated. We found a panel of benzisoselenaz

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Toenjes, Kurt A., Benjamin C. Stark, Krista M. Brooks, and Douglas I. Johnson. "Inhibitors of cellular signalling are cytotoxic or block the budded-to-hyphal transition in the pathogenic yeast Candida albicans." Journal of Medical Microbiology 58, no. 6 (2009): 779–90. http://dx.doi.org/10.1099/jmm.0.006841-0.

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The pathogenic yeast Candida albicans can grow in multiple morphological states including budded, pseudohyphal and true hyphal forms. The ability to interconvert between budded and hyphal forms, herein termed the budded-to-hyphal transition (BHT), is important for C. albicans virulence, and is regulated by multiple environmental and cellular signals. To identify small-molecule inhibitors of known cellular processes that can also block the BHT, a microplate-based morphological assay was used to screen the BIOMOL–Institute of Chemistry and Cell Biology (ICCB) Known Bioactives collection from the

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Rao, Xingyu, Zicheng Lei, Huifang Zhu, Kaiyuan Luo, and Chaohua Hu. "Knockdown of KIF23 alleviates the progression of asthma by inhibiting pyroptosis." BMJ Open Respiratory Research 11, no. 1 (2024): e002089. http://dx.doi.org/10.1136/bmjresp-2023-002089.

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BackgroundAsthma is a chronic disease affecting the lower respiratory tract, which can lead to death in severe cases. The cause of asthma is not fully known, so exploring its potential mechanism is necessary for the targeted therapy of asthma.MethodAsthma mouse model was established with ovalbumin (OVA). H&E staining, immunohistochemistry and ELISA were used to detect the inflammatory response in asthma. Transcriptome sequencing was performed to screen differentially expressed genes (DEGs). The role of KIF23 silencing in cell viability, proliferation and apoptosis was explored by cell coun

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Sharma, Sumana, and Evangelia Petsalaki. "Application of CRISPR-Cas9 Based Genome-Wide Screening Approaches to Study Cellular Signalling Mechanisms." International Journal of Molecular Sciences 19, no. 4 (2018): 933. http://dx.doi.org/10.3390/ijms19040933.

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Garcia, Mar Arias, Miguel Sanchez Alvarez, Heba Sailem, Vicky Bousgouni, Julia Sero, and Chris Bakal. "Differential RNAi screening provides insights into the rewiring of signalling networks during oxidative stress." Molecular BioSystems 8, no. 10 (2012): 2605. http://dx.doi.org/10.1039/c2mb25092f.

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Nabil, Muhammad, Azman Seeni, Wan Ismahanisa Ismail, and Nurhidayah Ab Rahim. "Proteomic Analysis of Anti-Cancer Effects of Streblus Asper Extract on HeLa Cancer Cells." Biomedical & Pharmacology Journal 12, no. 3 (2019): 1263–77. http://dx.doi.org/10.13005/bpj/1755.

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Cervical cancer is the third most common cancer affecting women worldwide. This occurs despite having precancerous screening and HPV vaccination implemented vigorously as a definitive intervention. Natural plant like Streblus asper has been discovered to offer great hope in treating and preventing cancers. In this study, we explored the potential of S.asper to inhibit the growth of cervical cancer cell line by using liquid chromatography mass spectrometry (LCMS). Upon analysis, seventy-six proteins that are common to both untreated and treated groups were identified. Of this, 14 proteins are f

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NIU, Jiaxin, Astrid SCHESCHONKA, Kirk M. DRUEY, et al. "RGS3 interacts with 14-3-3 via the N-terminal region distinct from the RGS (regulator of G-protein signalling) domain." Biochemical Journal 365, no. 3 (2002): 677–84. http://dx.doi.org/10.1042/bj20020390.

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RGS3 belongs to a family of the regulators of G-protein signalling (RGS), which bind and inhibit the Gα subunits of heterotrimeric G-proteins via a homologous RGS domain. Increasing evidence suggests that RGS proteins can also interact with targets other than G-proteins. Employing yeast two-hybrid screening of a cDNA library, we identified an interaction between RGS3 and the phosphoserine-binding protein 14-3-3. This interaction was confirmed by in vitro binding and co-immunoprecipitation experiments. RGS3-deletion analysis revealed the presence of a single 14-3-3-binding site located outside

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Shkhyan, Ruzanna, Ben Van Handel, Jacob Bogdanov, et al. "Drug-induced modulation of gp130 signalling prevents articular cartilage degeneration and promotes repair." Annals of the Rheumatic Diseases 77, no. 5 (2018): 760–69. http://dx.doi.org/10.1136/annrheumdis-2017-212037.

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ObjectiveHuman adult articular cartilage (AC) has little capacity for repair, and joint surface injuries often result in osteoarthritis (OA), characterised by loss of matrix, hypertrophy and chondrocyte apoptosis. Inflammation mediated by interleukin (IL)-6 family cytokines has been identified as a critical driver of proarthritic changes in mouse and human joints, resulting in a feed-forward process driving expression of matrix degrading enzymes and IL-6 itself. Here we show that signalling through glycoprotein 130 (gp130), the common receptor for IL-6 family cytokines, can have both context-s

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Van der Merwe, Alex. "Does Human Capital Theory Explain The Value Of Higher Education? A South African Case Study." American Journal of Business Education (AJBE) 3, no. 1 (2010): 107–18. http://dx.doi.org/10.19030/ajbe.v3i1.378.

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A perennial debate in the economics of education is whether human capital or screening/signalling theories best explain the value of schooling and hence the private demand for, in particular, higher education. Human capital theory proposes that formal training such as that offered by higher education institutions improves the productive capacity of individuals. Screening theory, on the other hand, posits that the value of higher education credentials flows primarily from their value as signals to potential employers of the abilities of the holders of such qualifications. Following the applicat

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Aina, Carmen, and Francesco Pastore. "Delayed Graduation and Overeducation in Italy: A Test of the Human Capital Model Versus the Screening Hypothesis." Social Indicators Research 152, no. 2 (2020): 533–53. http://dx.doi.org/10.1007/s11205-020-02446-0.

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Abstract Exploiting the human capital versus screening hypothesis frameworks, this paper studies the link between delayed graduation and overeducation, and their effect on wages, by using the ISFOL-Plus data. The evidence lines towards predictions based on the signalling model. However, as to the determinants of overeducation the coefficient of delayed graduation is significant only for delays of 3 years or more and also controlling for the entire set of covariates. This suggests that delay conveys a signal of low skill.

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Jensen, Adina R. D., Edward R. Horton, Lene H. Blicher, et al. "Organ-Specific, Fibroblast-Derived Matrix as a Tool for Studying Breast Cancer Metastasis." Cancers 13, no. 13 (2021): 3331. http://dx.doi.org/10.3390/cancers13133331.

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During the metastatic process, breast cancer cells must come into contact with the extra-cellular matrix (ECM) at every step. The ECM provides both structural support and biochemical cues, and cell–ECM interactions can lead to changes in drug response. Here, we used fibroblast-derived ECM (FDM) to perform high throughput drug screening of 4T1 breast cancer cells on metastatic organ ECM (lung), and we see that drug response differs from treatment on plastic. The FDMs that we can produce from different organs are abundant in and contains a complex mixture of ECM proteins. We also show difference

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Fournier, Louis-Alexandre, Forouh Kalantari, James P. Wells, et al. "Genome-Wide CRISPR Screen Identifies KEAP1 Perturbation as a Vulnerability of ARID1A-Deficient Cells." Cancers 16, no. 17 (2024): 2949. http://dx.doi.org/10.3390/cancers16172949.

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ARID1A is the core DNA-binding subunit of the BAF chromatin remodeling complex and is mutated in about 8% of all cancers. The frequency of ARID1A loss varies between cancer subtypes, with clear cell ovarian carcinoma (CCOC) presenting the highest incidence at > 50% of cases. Despite a growing understanding of the consequences of ARID1A loss in cancer, there remains limited targeted therapeutic options for ARID1A-deficient cancers. Using a genome-wide CRISPR screening approach, we identify KEAP1 as a genetic dependency of ARID1A in CCOC. Depletion or chemical perturbation of KEAP1 results in

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Kostyrko, Andrzej, Joanna Hauser, Janusz K. Rybakowski, and Wiesław H. Trzeciak. "Screening of chromosomal region 21q22.3 for mutations in genes associated with neuronal Ca2+ signalling in bipolar affective disorder." Acta Biochimica Polonica 53, no. 2 (2006): 317–20. http://dx.doi.org/10.18388/abp.2006_3345.

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The therapeutic effect of lithium in bipolar affective disorder may be connected with decreasing intracellular Ca(2+) concentrations. Several linkage studies have identified a potential bipolar affective disorder susceptibility locus within chromosomal region 21q22.3. This locus contains two genes expressed in the brain - ADARB1 and TRPM2 - involved in regulating intracellular Ca(2+) concentrations. The aim of this study was an identification of mutations in the coding sequences of ADARB1 and TRPM2 and their association with bipolar affective disorder. For that purpose we screened 60 patients

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