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Littérature scientifique sur le sujet « Silymarin/ Silibinin »

Auteur : Grafiati

Publié le 7 juin 2025

Mis à jour le 2 août 2025

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Articles de revues sur le sujet "Silymarin/ Silibinin"

Jiang, Hui-Hui, Fa-Shun Yan, Liang Shen, and Hong-Fang Ji. "Silymarin versus Silibinin: Differential Antioxidant and Neuroprotective Effects against H2O2-induced Oxidative Stress in PC12 Cells." Natural Product Communications 11, no. 5 (2016): 1934578X1601100. http://dx.doi.org/10.1177/1934578x1601100520.

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The present study assessed comparatively the antioxidant activities of silymarin and its major active component silibinin and their neuroprotective effects against hydrogen peroxide (H2O2)-induced oxidative stress in rat pheochromocytoma PC12 cells. It was found that despite newly prepared silymarin and silibinin solution possessing comparable superoxide anion (O2.–)-scavenging activities, with time the activity of silymarin lowered slightly, but that of silibinin decreased dramatically. Both silymarin and silibinin suppressed H2O2-induced oxidative stress and apoptosis, and the neuroprotectiv

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Rakelly de Oliveira, Dayanne, Saulo Relison Tintino, Maria Flaviana Bezerra Morais Braga, et al. "In VitroAntimicrobial and Modulatory Activity of the Natural Products Silymarin and Silibinin." BioMed Research International 2015 (2015): 1–7. http://dx.doi.org/10.1155/2015/292797.

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Silymarin is a standardized extract from the dried seeds of the milk thistle (Silybum marianumL. Gaertn.) clinically used as an antihepatotoxic agent. The aim of this study was to investigate the antibacterial and antifungal activity of silymarin and its major constituent (silibinin) against different microbial strains and their modulatory effect on drugs utilized in clinical practice. Silymarin demonstrated antimicrobial activity of little significance against the bacterial strains tested, with MIC (minimum inhibitory concentration) values of 512 µg/mL. Meanwhile, silibinin showed significant

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Kang, Min Kyung, Soo Kyung Bae, Jin Wan Kim, and Myung Gull Lee. "Pharmacokinetic Interaction Between Oltipraz and Silymarin in Rats." Journal of Pharmacy & Pharmaceutical Sciences 12, no. 1 (2009): 1. http://dx.doi.org/10.18433/j38c7w.

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ABSTRACT. Purpose: To evaluate the pharmacokinetic interaction between oltipraz and silymarin after intravenous and oral administration of both drugs to male Sprague–Dawley rats. Methods: Oltipraz (single doses of 10 and 30 mg/kg for intravenous and oral administration, respectively), silymarin (single doses of 50 and 100 mg/kg for intravenous and oral administration, respectively, and 14 days oral administration of 100 mg/kg), alone and together were administered to control rats. Results: The pharmacokinetic parameters of oltipraz did not significantly altered by silymarin. However, after int

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Duan, Wentao, Zexian Ou, Yuxing Huang, et al. "Silibinin Inhibits Cell Ferroptosis and Ferroptosis-Related Tissue Injuries." Antioxidants 12, no. 12 (2023): 2119. http://dx.doi.org/10.3390/antiox12122119.

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Ferroptosis is involved in various tissue injuries including neurodegeneration, ischemia-reperfusion injury, and acute liver injury. Ferroptosis inhibitors exhibit promising clinical potential in the treatment of various diseases. As a traditional chemical, silymarin has been widely used in healthcare and clinical applications to treat liver injuries in which ferroptosis is involved. Silibinin is the main active ingredient of silymarin. However, the effect of silibinin on ferroptosis and ferroptosis-related diseases remains unclear. Here, we found that silibinin inhibited death in different ki

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Kadoglou, Nikolaos P. E., Chrystalla Panayiotou, Michail Vardas, et al. "A Comprehensive Review of the Cardiovascular Protective Properties of Silibinin/Silymarin: A New Kid on the Block." Pharmaceuticals 15, no. 5 (2022): 538. http://dx.doi.org/10.3390/ph15050538.

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Silibinin/silymarin has been used in herbal medicine for thousands of years and it is well-known for its hepato-protective properties. The present comprehensive literature review aimed to critically summarize the pharmacological properties of silymarin extract and its main ingredient silibinin in relation to classical cardiovascular risk factors (e.g., diabetes mellitus, etc.). We also assessed their potential protective and/or therapeutic application in cardiovascular diseases (CVDs), based on experimental and clinical studies. Pre-clinical studies including in vitro tests or animal models ha

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Milić, Nataša, Nataša Milošević, Ljiljana Suvajdžić, Marija Žarkov, and Ludovico Abenavoli. "New Therapeutic Potentials of Milk Thistle (Silybum marianum)." Natural Product Communications 8, no. 12 (2013): 1934578X1300801. http://dx.doi.org/10.1177/1934578x1300801236.

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Silymarin is a bioflavonoid complex extract derived from dry seeds of Milk thistle [( Silybum marianum(L.) Gaernt. (Fam. Asteraceae/Compositaceae)] whose hepatoprotective effect has clinically been proved. Low toxicity, favorable pharmacokinetics, powerful antioxidant, detoxifying, preventive, protective and regenerative effects and side effects similar to placebo make silymarin extremely attractive and safe for therapeutic use. The medicinal properties of silymarin and its main component silibinin have been studied in the treatment of Alzheimer's disease, Parkinson's disease, sepsis, burns, o

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AKBEL, Erten, İbrahim BULDUK, and Funda KARABAĞ. "Developing Rp-Hplc Method and Determination in Vitro Cytotoxicity of Silymarin Obtained From Silybum marinum Plant." MAS Journal of Applied Sciences 9, Special Issue (2024): 899–906. https://doi.org/10.5281/zenodo.13939065.

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The Asteraceae family's Silybum marinum plant, commonly known as thistle, yields silymarin in its seeds. A frequently employed hepato-protective treatment for conditions like cirrhosis, fatty liver due to alcohol and hazardous chemicals, and hepatitis is silymarin. Conventional milk thistle extract is derived from seeds containing a silymarin content of 4-6%. The extract has 20–35% fatty acids, including linoleic acid, and 65–80% silymarin (a flavonolignan complex). Silymarin constitutes a complex blend of polyphenolic compounds that also contains a flavonoid (taxifolin) a

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Shiri, Sabah, Naser Abbasi, Kamal Alizadeh, and Elahe Karimi. "Novel and green synthesis of a nanopolymer and its use as a drug delivery system of silibinin and silymarin extracts in the olfactory ensheathing cells of rats in normal and high-glucose conditions." RSC Advances 9, no. 67 (2019): 38912–27. http://dx.doi.org/10.1039/c9ra05608d.

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A schematic of a new synthesized nanopolymer (CGONP) and its use as a drug delivery system of silibinin and silymarin extract in the olfactory ensheathing cells (OECs) of rats in normal and high-glucose conditions.

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Verdura, Sara, Elisabet Cuyàs, Verónica Ruiz-Torres, et al. "Lung Cancer Management with Silibinin: A Historical and Translational Perspective." Pharmaceuticals 14, no. 6 (2021): 559. http://dx.doi.org/10.3390/ph14060559.

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The flavonolignan silibinin, the major bioactive component of the silymarin extract of Silybum marianum (milk thistle) seeds, is gaining traction as a novel anti-cancer therapeutic. Here, we review the historical developments that have laid the groundwork for the evaluation of silibinin as a chemopreventive and therapeutic agent in human lung cancer, including translational insights into its mechanism of action to control the aggressive behavior of lung carcinoma subtypes prone to metastasis. First, we summarize the evidence from chemically induced primary lung tumors supporting a role for sil

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Ahmadi, Yasin, Mohammad Mehdi Mahboobian, and Mojdeh Mohammadi. "Silibinin and Nano-silibinin in Cuprizone Model of Multiple Sclerosis: Behavioral and Biochemical Investigation." Current Drug Therapy 16, no. 5 (2021): 439–47. http://dx.doi.org/10.2174/1574885517666211216161317.

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Objectives: Multiple sclerosis (MS) is a long-lasting demyelinating inflammatory disease of the central nervous system (CNS). It has been shown that brain tissue in MS is exposed to oxidative stress during the disease period. Silymarin, a plant-derived flavonoid, can be extracted from Silybum marianum. The current experiment aimed to explore the effects of silibinin and especially nano-silibinin on neurobehavioral activity and biochemical antioxidant parameters in the cuprizone model of demyelination in mice for the first time. Methods: Demyelination was induced in mice by oral consumption of

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Thèses sur le sujet "Silymarin/ Silibinin"

Borges, Flavio Fernandes Veloso. "Atividades antimutagênica, antigenotóxica e anticitotóxica de Silybum marianum (L.) Gaertn e sua influência na expressão de genes de resposta a danos no DNA." Universidade Federal de Goiás, 2015. http://repositorio.bc.ufg.br/tede/handle/tede/5205.

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Submitted by Cláudia Bueno (claudiamoura18@gmail.com) on 2016-02-04T10:23:14Z No. of bitstreams: 2 Tese - Flavio Fernandes Veloso Borges - 2015.pdf: 2110689 bytes, checksum: 595ebd21ecf4f13568b0e3179e801f99 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2016-02-04T10:43:08Z (GMT) No. of bitstreams: 2 Tese - Flavio Fernandes Veloso Borges - 2015.pdf: 2110689 bytes, checksum: 595ebd21ecf4f13568b0e3179e801f99 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b863

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Roy, Srirupa. "Defining the mechanism of action of silibinin as an anti-cancer and cancer chemopreventive agent /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2008.

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Thesis (Ph.D. in Toxicology) -- University of Colorado Denver, 2008. Typescript. Includes bibliographical references (leaves 144-170). Free to UCD Anschutz Medical Campus. Online version available via ProQuest Digital Dissertations;

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Oliveira, Dayanne Rakelly de. "SILIMARINA MODIFICA A ATIVIDADE DA NA+/K+-ATPASE E DA MAO E MODULA A AÇÃO DE ANTIMICROBIANOS IN VITRO." Universidade Federal de Santa Maria, 2015. http://repositorio.ufsm.br/handle/1/4493.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior The Silymarin is a flavonolignan complex isolated from milk thistle seeds of Silybum marianum being used in the treatment of injury related to oxidative stress, including liver and neurological diseases, as Parkinson disease. Although silymarin has been reported to possess a variety of pharmacological properties including anti-inflammatory, anticarcinogenic and neuroprotective effects, information regard its antimicrobial and drug modulator potential against microbial resistance is scanty in the literature. In addition, the possibl

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Boutin, Elodie. "Mécanisme d'inhibition de la fusion membranaire du virus de l'hépatite C par différents composés : l'arbidol, la silymarine et les molécules la composant." Thesis, Lyon 1, 2010. http://www.theses.fr/2010LYO10244.

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L'infection par le virus de l'hépatite C (VHC) est un problème de santé publique majeur car en absence de vaccin et de thérapie suffisamment efficace, l’infection peut dégénérer en carcinome hépatocellulaire. Il est alors important d’identifier de nouvelles cibles thérapeutiques et de développer de nouveaux antiviraux. Ainsi, nous avons étudié l'activité anti-VHC de différents composés : l'arbidol (Arb), la silymarine (SM) et les molécules la composant, notamment la silibinine (SbN). Ces composés ont l'avantage d'être déjà utilisés en médecine humaine depuis de nombreuses années et ont ainsi p

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Chang, Jen-Chih, and 張仁治. "Herb-drug Interactions of Silymarin and Silibinin on the Pharmacokinetics of Protein-unbound Trazodone in Rats." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/hr77ge.

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碩士 國立陽明大學 傳統醫藥學研究所 97 Silymarin, one of the most popular herbal medicines, has been widely used for its hepatoprotective effects. The aim of this study is to investigate the effects of silymarin and its major ingredient silibinin on the pharmacokinetics of the antidepressant trazodone. Male Sprague-Dawley rats were randomly divided into six groups in a parallel design as follows: one group treated single-dose silymarin (1.0 g/kg) 4 h prior to the administration of trazodone, the control group treated with vehicle, two groups pretreated with 0.175 and 0.35 g/kg/day silibinin and ano

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Chapitres de livres sur le sujet "Silymarin/ Silibinin"

Aksoyalp, Zinnet Şevval, and Betül Rabia Erdoğan. "Type 1 Diabetes Mellitus and Herbal Medicines." In Herbal Medicine for Autoimmune Diseases. BENTHAM SCIENCE PUBLISHERS, 2024. http://dx.doi.org/10.2174/9789815305005124010007.

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The global incidence of type 1 diabetes mellitus (T1DM) is rising substantially and T1DM remains a marked economic burden despite advances in the diagnosis, prevention, and treatment of complications. T1DM, often associated with autoimmune disease, is characterized by insulin deficiency and insufficiency due to beta cell destruction. The primary treatment for T1DM is insulin therapy, limited by the risk of hypoglycemia and weight gain. Other treatments for T1DM are teplizumab and donislecel, which have recently received FDA approval. Beyond these treatment options, T1DM patients are interested

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